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Cafestol inhibits colon cancer cell proliferation and tumor growth in xenograft mice by activating LKB1/AMPK/ULK1-dependent autophagy J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-03-15 Yuemei Feng, JiZhuo Yang, Yihan Wang, Xue Wang, Qian Ma, Yalin Li, Xuehui Zhang, Songmei Wang, Qiao Zhang, Fei Mi, Yanjiao Wang, Dubo Zhong, Jianzhong Yin
Chemotherapy failure in colorectal cancer patients is the major cause of recurrence and poor prognosis. As a result, there is an urgent need to develop drugs that have a good chemotherapy effect while also being extremely safe. In this study, we found cafestol inhibited colon cancer growth and HCT116 proliferation in vivo and in vitro, and improved the composition of intestinal flora. Further metabolomic
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Dietary polyphenols represent a phytotherapeutic alternative for gut dysbiosis associated neurodegeneration: A Systematic review J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-03-13 Amrita Chatterjee, Satish Kumar, Suparna Roy Sarkar, Ritabrata Halder, Rashmi Kumari, Sugato Banerjee, Biswatrish Sarkar
Globally, neurodegeneration and cerebrovascular disease are common and growing causes of morbidity and mortality. Pathophysiology of this group of diseases encompasses various factors from oxidative stress to gut microbial dysbiosis. The study of the etiology and mechanisms of oxidative stress as well as gut dysbiosis-induced neurodegeneration in Alzheimer's disease, Parkinson's disease, multiple sclerosis
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Retraction notice to “Influence of gestational overfeeding on myocardial proinflammatory mediators in fetal sheep heart” [The Journal of Nutritional Biochemistry 24 (2013) 1982-1990] J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-03-11 Machender R. Kandadi, Yinan Hua, Meijun Zhu, Subat Turdi, Peter W. Nathanielsz, Stephen P. Ford, Sreejayan Nair, Jun Ren
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The gustin gene variation at rs2274333 and PROP taster status affect dietary fat perception: a stepwise multiple regression model study J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-03-10 Gowtham Subramanian, Vinithra Ponnusamy, Keerthana Vasanthakumar, Prabha Panneerselvan, Vasanth Krishnan, Selvakumar Subramaniam
Gustin, a trophic factor for taste bud development, and its polymorphism at rs2274333 influence taste perception of 6-n-propylthiouracil (PROP) and fungiform papillae (FP) density. The PROP taster status affects dietary fat sensing and body composition. However, there is a paucity of research on the gustin genotype with dietary fat perception, PROP tasting ability, and body mass index (BMI). Thus,
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A maternal low-protein diet impaired glucose metabolism and altered the lncRNA profiles of islets in adult offspring J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-03-10 Yanli Li, Yalan Chen, Beisi Lin, Ziyu Liu, Fen Xu, Dalong Song, Kanshou Che, Danrui Chen, Yanna Su, Wangen Li, Wen Xu
A maternal low-protein diet during pregnancy can increase children's susceptibility to diabetes mellitus in adulthood. However, whether lncRNAs in islets participate in the development of diabetes in adult offspring following maternal protein restriction is not fully understood. Female mice were fed a low-protein (LP) diet or control diet throughout gestation and lactation. The male offspring were
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Vitamin C deficiency alters the transcriptome of the rat brain in a glucocorticoid-dependent manner, leading to microglial activation and reduced neurogenesis J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-03-06 Shunta Goto, Natsuki Kojima, Miyu Komori, Noe Kawade, Kenzi Oshima, Daita Nadano, Nobumitsu Sasaki, Fumihiko Horio, Tsukasa Matsuda, Shinji Miyata
Vitamin C (VitC) is maintained at high concentrations in the brain and is an essential micronutrient for brain function. VitC deficiency leads to neuropsychiatric scurvy, which is characterized by depression and cognitive impairment. However, the molecular mechanism by which mild VitC deficiency impairs brain function is currently unknown. In the present study, we conducted RNA sequencing analysis
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Vitamin D3 mitigates type 2 diabetes induced by a high carbohydrate-high fat diet in rats: Role of the purinergic system J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-02-18 Milagros Fanny Vera Castro, Charles Elias Assmann, Karine Paula Reichert, Priscila Marquezan Coppetti, Naiara Stefanello, Aniélen Dutra da Silva, Vitor Bastianello Mostardeiro, Loren Borba de Jesus, Marcylene Vieira da Silveira, Adriel Antonio Schirmann, Mateus Fracasso, Roberto Marinho Maciel, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinger
This study evaluated the effect of vitamin D (VIT D) supplementation on the enzymatic activities and density of ectonucleoside triphosphate diphosphohydrolase (E-NTPDase), ecto-5-nucleotidase (E-5′-NT), adenosine deaminase (ADA), as well as the density of P2 × 7R, P2Y12R, A1R, A2AR receptors, IL-1β, and oxidative parameters in type 2 diabetic rats. Forty male Wistar rats were fed a high carbohydrate-high
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Interplay between maternal nutrition and epigenetic programming on offspring hypertension J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-02-18 You-Lin Tain, Chien-Ning Hsu
Recent human and animal studies have delineated hypertension can develop in the earliest stage of life. A lack or excess of particular nutrients in the maternal diet may impact the expression of genes associated with BP, leading to an increased risk of hypertension in adulthood. Modulations in gene expression could be caused by epigenetic mechanisms through aberrant DNA methylation, histone modification
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N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-02-17 Yanqing Wang, Huanying Zhang, Feng Ding, Jianhua Li, Lianyu Li, Zhong Xu, Yan Zhao
Alzheimer's disease (AD) is a common neurodegenerative disease that causes progressive cognitive decline. A major pathological characteristic of AD brain is the presence of senile plaques composed of β-amyloid (Aβ), the accumulation of which induces toxic cascades leading to synaptic dysfunction, neuronal apoptosis and eventually cognitive decline. Dietary n-3 polyunsaturated fatty acids (PUFAs), such
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Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-02-15 Perry C. Caviness, Oxana P. Lazarenko, Michael L. Blackburn, Jennifer F. Chen, Christopher E. Randolph, Jovanny Zabaleta, Fenghuang Zhan, Jin-Ran Chen
Phenolic acids, such as hippuric acid (HA) and 3-(3-hydroxyphenyl) propionic acid (3-3-PPA), can be produced from microbiome digestion of polyphenols. Previously it was found that HA and 3-3-PPA facilitate bone formation and suppress bone resorption. However, the mechanism of action by which HA and 3-3-PPA protect bone from degeneration is currently unknown. In this report, we present that HA and 3-3-PPA
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The pathogenesis of food allergy and protection offered by dietary compounds from the perspective of epigenetics J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-02-07 Fan Yang, Xing Zhang, Yanhai Xie, Juanli Yuan, Jinyan Gao, Hongbing Chen, Xin Li
Food allergy is a global food safety concern, with an increasing prevalence in recent decades. However, the immunological and cellular mechanisms involved in allergic reactions remain incompletely understood, which impedes the development of effective prevention and treatment strategies. Current evidence supports those epigenetic modifications regulate the activation of immune cells, and their dysregulation
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Nutrient-Epigenome interactions: Implications for personalized nutrition against aging-associated diseases J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-02-05 Hemi Missong, Riya Joshi, Naina Khullar, Suresh Thareja, Umashanker Navik, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti
Ageing is a multifaceted process involving genetic and environmental interactions often resulting in epigenetic changes, potentially leading to ageing-related diseases. Various strategies, like dietary interventions and calorie restrictions, have been employed to modify these epigenetic landscapes. A burgeoning field of interest focuses on the role of microbiota in human health, emphasizing system
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Sex-Specific Effects of Ketogenic Diet on Anxiety-like Behavior and Neuroimmune Response in C57Bl/6J Mice J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-02-02 Mohit Kumar, Babita Bhatt, Chitralekha Gusain, Nayan Mahajan, Mahendra Bishnoi
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Anti-obesity effect of butyrate links to modulation of gut microbiome and epigenetic regulation of muscular circadian clock J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-02-02 Jinyoung Shon, Yerim Han, Seungmin Song, Soyoung Kwon, Khuhee Na, Anders M. Lindroth, Yoon Jung Park
The role of the muscle circadian clock in regulating oxidative metabolism exerts a significant influence on whole-body energy metabolism; however, research on the connection between the muscle circadian clock and obesity is limited. Moreover, there is a lack of studies demonstrating the regulatory effects of dietary butyrate on muscle circadian clock and the resulting anti-obesity effects. This study
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All-trans retinoic acid induces lipophagy through the activation of the AMPK-Beclin1 signaling pathway and reduces Rubicon expression in adipocytes J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-02-01 Yuki Mori, Masashi Masuda, Risa Yoshida-Shimizu, Saki Aoyagi, Yuichiro Adachi, Anh The Nguyen, Yusuke Maruyama, Yosuke Okumura, Yuki Kamei, Maiko Sakai, Kohta Ohnishi, Hirokazu Ohminami, Yutaka Taketani
Lipophagy is defined as a lipolysis pathway that degrades lipid droplet (LD) autophagy. All- retinoic acid (atRA), a metabolite of vitamin A, stimulates lipolysis through hormone-sensitive lipase and β-oxidation. However, the regulation of lipolysis by atRA-induced autophagy in adipocytes remains unclear. In this study, we investigated the effect of atRA on autophagy in epididymal fat of mice and the
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Lipids and lipid signaling molecules in human milk and infant formula, a chemical characterization of relevant biochemical components J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-23 Roberta Ottria, Matteo Della Porta, Ornella Xynomilakis, Sara Casati, Roberta Cazzola, Pierangela Ciuffreda
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Thinned young apple powder prevents obesity-induced neuronal apoptosis via improving mitochondrial function of cerebral cortex in mice J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-22 Jiacheng Fang, Peng Jiang, Xincen Wang, Zhongshi Qi, Xin He, Lei Chen, Yurong Guo, Xiaoyun Xu, Run Liu, Duo Li
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Creatine supplementation with exercise reduces α-synuclein oligomerization and necroptosis in Parkinson's disease mouse model J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-21 Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Yeon Kim, Hee-Sun Kim
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Calorie restriction mimetic, resveratrol, attenuates hepatic ischemia and reperfusion injury through enhancing efferocytosis of macrophages via AMPK/STAT3/S1PR1 pathway J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-21 Xueya Yao, Yingxiang Liu, Menghan Mao, Liqun Yang, Qionghui Zhan, Jie Xiao
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Dietary purple potato supplement attenuates DSS-induced colitis in mice: impact on mitochondrial function J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-20 Qi Sun, Shima Bibi, Yansong Xue, Min Du, Boon Chew, Mei-Jun Zhu
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Very low-carbohydrate diet with higher protein ratio improves lipid metabolism and inflammation in rats with diet-induced nonalcoholic fatty liver disease J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-18 I-Ting Wu, Wan-Ju Yeh, Wen-Chih Huang, Hsin-Yi Yang
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Fructose dose-dependently influences colon barrier function by regulation of some main physical, immune, and biological factors in rats J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-18 Qianyun Gan, Ge Song, Wei Fang, Yong Wang, Wentao Qi
Little is known about the effects of fructose on colonic function. Here, forty-eight 7-week-old male SD rats were randomly divided into four groups and given 0, 7.5%, 12.75%, and 35% fructose in diet for 8 weeks respectively to investigate the regulatory influence of fructose on colonic barrier function. The exact amount of fructose intake was tracked and recorded. We showed that fructose affects colonic
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Identification of potential pathogenic hepatic super-enhancers regulatory network in high-fat diet induced hyperlipidemia J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-17 Yingying Hu, Run Xu, Jing Feng, Qingwei Zhang, Lifu Zhang, Yiyang Li, Xiuxiu Sun, Jin Gao, Ximing Chen, Menghan Du, Zhouxiu Chen, Xin Liu, Yuhua Fan, Yong Zhang
Hyperlipidemia (HLP) is a prevalent metabolic disorder and a significant risk factor for cardiovascular disease. According to recent discoveries, super-enhancers (SEs) play a role in the increased expression of genes that encode important regulators of both cellular identity and the progression of diseases. However, the underlying function of SEs in the development of HLP is still unknown. We performed
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High salt diet exacerbates cognitive deficits and neurovascular abnormalities in APP/PS1 mice and induces AD-like changes in wild-type mice J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-11 Chen Hai-Chao, Cao Jia-Xin, Zhang Yi-Shu, Ma Yue-Zhang, Zhang Lu, Su Xiao-Mei, Gao Li-Ping, Jing Yu- Hong
High salt diet (HSD) is a risk factor of hypertension and cardiovascular disease. Although clinical data do not clearly indicate the relationship between HSD and the prevalence of Alzheimer's disease (AD), animal experiments have shown that HSD can cause hyperphosphorylation of tau protein and cognition impairment. However, whether HSD can accelerate the progression of AD by damaging the function of
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Molecular mechanism and therapeutic significance of essential amino acids in metabolically associated fatty liver disease J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-12 Yuting Deng, Mengsi Hu, Shufang Huang, Nian Fu
Non-alcoholic fatty liver disease (NAFLD), also known as metabolically associated fatty liver disease (MAFLD), is a systemic metabolic disease characterized by lipid accumulation in the liver, lipid toxicity, insulin resistance, intestinal dysbiosis, and inflammation that can progress from simple steatosis to nonalcoholic steatohepatitis (NASH) and even cirrhosis or cancer. It is the most prevalent
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Alginate oligosaccharide alleviates vascular aging by upregulating glutathione peroxidase 7 J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-10 Shan Wang, Yao Yu, Jia Liu, Song Hu, Shujuan Shi, Wenjing Feng, Yongjun Mao
Alginate oligosaccharide (AOS) may delay aging by decreasing oxidative stress, but the effects on vascular aging remain unclear. Here, we evaluate the effect of AOS on vascular aging and investigate the underlying mechanisms. Twenty-month-old rats acted as the natural aging model . Senescence of human aortic vascular smooth muscle cells (HA-VSMCs) was induced using angiotensin II (AngII). The aging
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Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-08 Kay Li Hui Wu, Wen-Chung Liu, Chih-Wei Wu, Mu-Hui Fu, Hsiu-Mei Huang, You-Lin Tain, Chih-Kuang Liang, Chun-Ying Hung, I-Chun Chen, Pi-Lien Hung, Yu-Ju Lin, Hajime Hirase
Maternal nutrient intake influences the health of the offspring via microenvironmental systems in digestion and absorption. Maternal high fructose diet (HFD) impairs hippocampus-dependent memory in adult female rat offspring. However, the underlying mechanisms remain largely unclear. Maternal HFD causes microbiota dysbiosis. In this study, we find that the plasma level of butyrate, a major metabolite
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Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210 J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-06 Kuan-Ho Lin, Shang-Chuan Ng, Shang-Yeh Lu, Yueh-Min Lin, Shu-Hui Lin, Tzu-Cheng Su, Chih-Yang Huang, Wei-Wen Kuo
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Nano formulated Resveratrol inhibits PD-L1 in oral cancer cells by deregulating the association between tumor associated macrophages and cancer associated fibroblasts through IL-6/JAK2/STAT3 signaling axis J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-06 Rajalaxmi Pradhan, Subarno Paul, Sushree Subhadra Acharya, Saptarshi Sinha, Somya Ranjan Dash, Chanakya Nath Kundu
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Antifibrotic effects of vitamin D3 on human lung fibroblasts derived from patients with idiopathic pulmonary fibrosis J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-05 Tom Voisin, Audrey Joannes, Claudie Morzadec, Dominique Lagadic-Gossmann, Cécile Le Naoures, Bertrand Richard De Latour, Simon Rouze, Stéphane Jouneau, Laurent Vernhet
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Up to now, no treatment can stop the progression of IPF. Vitamin D3 (VD) reduces experimental lung fibrosis in murine models and depletion of vitamin D3 might be associated with the reduced survival of patients with IPF. In this context, we determined if VD can prevent the pro-fibrotic functions of human lung
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Spermidine activates adipose tissue thermogenesis through autophagy and fibroblast growth factor 21 J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-05 Yinhua Ni, Liujie Zheng, Liqian Zhang, Jiamin Li, Yuxiang Pan, Haimei Du, Zhaorong Wang, Zhengwei Fu
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Obesity phenotype induced by high-fat diet promotes diethylnitrosamine (DEN)-induced precancerous lesions by M1 macrophage polarization in mice liver J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-03 Li Tian, Du Zuoqin, Wu Jiaqi, Jin Xiaomeng, Deng Xin, Yang Yan, Zheng Youkun, Wu Jianbo
Liver precancerous lesions are the key to improving the efficacy of cancer treatment because of the extremely poor prognosis of HCC patients in moderate and late stages. Obesity-related HCC progression is closely related to the inflammatory microenvironment, in which macrophages are one of the major constituents. In the present study, we ask whether obesity promotes diethylnitrosamine (DEN)-induced
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Chronobiotics, satiety signaling, and clock gene expression interplay J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-03 Velásquez-Jiménez Dafne, Miranda-Anaya Manuel, Campos-Vega Rocio
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A very-low carbohydrate content in a high-fat diet modifies the plasma metabolome and impacts systemic inflammation and experimental atherosclerosis J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-03 Rita Castro, Karel Kalecký, Neil K. Huang, Kristina Petersen, Vishal Singh, A. Catharine Ross, Thomas Neuberger, Teodoro Bottiglieri
Ketogenic diets (KDs) are very high-fat low-carbohydrate diets that promote nutritional ketosis and are widely used for weight loss, although concerns about potential adverse cardiovascular effects remain. We investigated a very high-fat KD's vascular impact and plasma metabolic signature compared to a non-ketogenic high-fat diet (HFD). Apolipoprotein E deficient ( mice were fed a KD (%kcal:81:1:18
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Dietary rice bran attenuates hepatic stellate cell activation and liver fibrosis in mice through enhancing antioxidant ability J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-03 Fang-Yu Hsu, Suh-Ching Yang, Fat-Moon Suk, Hitoshi Shirakawa, Wan-Chun Chiu, Yi-Jen Liao
Various endogenous and exogenous stimuli can result in an inflammatory response and collagen deposition in the liver, which affect liver function and increase the risk of developing liver cirrhosis and cancer. Rice bran, the main by-product of rice milling, contains various nutrients which possess hepatoprotective activities. In this study, we investigated the effects of rice bran on carbon tetrachloride
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Novel effects of prohibitin 1 expression level on cholesterol and lipid homeostasis J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-03 Soohan Jung, Hyeonju Yu, Kwang Suk Ko
Prohibitin 1 (PHB1) plays an important role in maintaining liver health and function. The PHB1 level is decreased in patients with various liver diseases. In this study, liver cancer was induced in liver-specific Phb1 knock-out mice, which were then subjected to hepatic gene and metabolomic analysis. The reduced expression of mRNA expression level of Phb1 induced down-regulation of cholesterol and
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Dietary selenomethionine reduced oxidative stress by resisting METTL3-mediated m6A methylation level of Nrf2 to ameliorate LPS-induced liver necroptosis in laying hens J. Nutr. Biochem. (IF 5.6) Pub Date : 2024-01-03 Shanshan Li, Yixuan Wang, Anqi Xu, Bing Zhao, Yu Xia, Yujiao He, Hua Xue, Shu Li
Selenomethionine (SeMet) as the main form of daily dietary selenium, occupies essential roles in providing antioxidant and anti-inflammatory properties, which alleviates inflammatory liver damage. N6-methyladenosine (m6A) is one of the most prevalent and abundant internal transcriptional modifications that regulate gene expression. To investigate the protective mechanism of SeMet on liver injury and
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Potential of Lactobacillus plantarum A56 in relieving food allergy through immunoregulation, antioxidation, and reshaping intestinal microbiota J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-31 Cuicui Duan, Lin Ma, Mengchun Qin, Lingfang Zhang, Shunan Hu, Lifan Liu, Yixue Sun, Fumin Ma, Dan Li
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Moderate replacement of fish oil with palmitic acid-stimulated mitochondrial fusion promotes β-oxidation by Mfn2 interacting with Cpt1α via its GTPase-domain J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-28 Yu–Feng Song, Ling-jiao Wang, Zhi Luo, Christer Hogstrand, Xiao-Hong Lai, Fei-fei Zheng
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Kaempferol improves Pb-induced cognitive impairments via inhibiting autophagy J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-26 Mengmeng Wang, Yanzhou Xia, Shu Ai, Xiaozhen Gu, Hui-Li Wang
Kaempferol (Kam) is a flavonoid antioxidant found in fruits and vegetables, which was discovered as neuroprotective antioxidants. Lead (Pb), an environmental pollution, could induce learning and memory deficits. Nevertheless, little is known about the mechanisms underlying Kam actions in Pb-induced learning and memory deficits. In this study, we investigated the effects of Kam on Pb-induced cognitive
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Pomegranate juice-containing serum inhibits migration of hepatocellular carcinoma cells and promotes apoptosis by induction of mitochondrial dysfunction J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-26 Ting Zhou, Heting Zhou, Li Tian, Minghai Tang, Liqun Wang, Yuhong Kang, Tao Chen, Xingjie Li, Shouxun Wu, Rui Xia, Xiaoyi Huang, Lijun Peng, Wenya Yin
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Betaine attenuates age-related suppression in autophagy via Mettl21c/p97/VCP axis to delay muscle loss J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-24 Si Chen, Jiedong Chen, Chen Wang, Tongtong He, Zhijun Yang, Wenge Huang, Xiaolin Luo, Huilian Zhu
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Oat-based postbiotics ameliorate high-sucrose induced liver injury and colitis susceptibility by modulating fatty acids metabolism and gut microbiota J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-24 Wei Song, Ruixue Wen, Tianqi Liu, Lanqi Zhou, Guoze Wang, Xiaoshuang Dai, Lin Shi
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Hippocampal proteomic changes in high-fat diet-induced obese mice associated with memory decline J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-22 Ping Lu, Cun-Xiu Gao, Fei-Jian Luo, Yu-Ting Huang, Mei-Mei Gao, Yue-Sheng Long
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Promotion of transcription factor EB-dependent autophagic process by curcumin alleviates arsenic-caused lung oxidative stress and inflammation in mice J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-21 Guowei Xu, Haiyang Chen, Zheng Cong, Ruiqiang Wang, Xiangping Li, Yuxuan Xie, Yi Wang, Bing Li
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7-Ketocholesterol plays a key role in cholesterol-induced hepatitis via macrophage and neutrophil infiltration J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-21 Guoen Li, Hyun-Jung Park, Jae-Hee Suh, Hye-Seon Choi
This study sought to explore the role of 7-ketocholesterol (7-KC) in liver damage caused by high cholesterol intake and its potential pathological mechanism in mice. Our in vivo findings indicated that mice fed a high-cholesterol diet had elevated serum levels of 7-KC, accompanied by liver injury and inflammation, similar to human nonalcoholic steatohepatitis. Furthermore, the high-cholesterol diet
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ZNF217-activated Notch signaling mediates sulforaphane-suppressed stem cell properties in colorectal cancer J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-20 Menghuan Wang, LvYuwei Tang, Siyu Chen, Liudan Wang, Jinyi Wu, Caiyun Zhong, Yadong Li, Yue Chen
Cancer stem cells (CSCs) are known to contribute to the progression of colorectal cancer (CRC). However, understanding of the molecular mechanisms and key factors involved in CRC is still insufficient to identify therapeutic targets against colorectal CSCs. In an effort to identify such mechanisms, we conducted bioinformatics analyses to evaluate the expression patterns in tumor and normal colorectal
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Body weight gain and control: beneficial effect of extra virgin olive oil versus corn oil in an experimental model of mammary cancer J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-15 Raquel Moral, Garyfallia Kapravelou, Marta Cubedo, Montserrat Solanas, Eduard Escrich
Obesity is a known risk factor for breast cancer, the most common malignancy among women worldwide. We have previously described different effects of high-fat diets on mammary experimental carcinogenesis. In this work, we analyzed the animal growth data obtained in six experimental assays, in healthy and carcinogen-induced rats undergoing different dietary interventions. The animals were fed with three
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Metabolome implies increased fatty acid utilization and histone methylation in the follicles from hyperandrogenic PCOS women J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-15 Yue Xu, Zhiyang Zhou, Gaochen Zhang, Zuwei Yang, Yan Shi, Zhaoying Jiang, Ye Liu, Huixi Chen, Hefeng Huang, Yu Zhang, Jiexue Pan
Well-balanced metabolism is essential for the high-quality of oocytes, and metabolic fluctuations of follicular microenvironment potentially encourage functional changes in follicle cells, ultimately impacting the developmental potential of oocytes. Here, the global metabolomic profiles of follicular fluid from PCOS women with ovarian hyperandrogenism and nonhyperandrogenism were depicted by untargeted
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Barley consumption under a high-fat diet suppresses lipogenic genes through altered intestinal bile acid composition J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-09 Kento Mio, Naoko Iida-Tanaka, Marina Togo-Ohno, Natsuki Tadenuma, Chiemi Yamanaka, Seiichiro Aoe
We evaluated whether barley flour consumption in a high-fat environment affects lipid metabolism through signals mediated by bile acids. Four-week-old mice were fed a high-fat diet supplemented with cellulose (HC) or β-glucan-rich barley flour (HB) for 12 weeks. Bile acid composition in the intestinal tract and feces was measured by GC/MS. Gene expression levels involved in bile acid metabolism in
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The synbiotic combination of probiotics and inulin improves NAFLD though modulating gut microbiota J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-12-08 Can Zhang, Tianqi Fang, Linlin Shi, Yidan Wang, Xuming Deng, Jianfeng Wang, Yonglin Zhou
Prebiotics can promote the growth of probiotics, cocombine of these is called synbiotics, and synbiotics is powerful regulators of gut microbiota. Intestinal microbiota plays an important role in nonalcoholic fatty liver disease (NAFLD), so synbiotics could be a therapeutic alternative. This study aims to investigate the effect of synbiotics combination of probiotics (Streptococcus Bifidobacterium
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Corrigendum to “EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-κB and MMP-9” [Journal of Nutritional Biochemistry 41 (2017) 56–64] J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-11-29 Ke-Wang Luo, Wei Chen, Wing-Yin Lung, Xia-Yun Wei, Bao-Hui Cheng, Zhi-Ming Cai, Wei-Ren Huang
Abstract not available
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Solanum melongena extract supplementation protected skeletal muscle and brain damage by regulation of BDNF/PGC1α/irisin pathway via brain function-related myokines in high-fat diet induced obese mice J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-11-27 Heaji Lee, Sun Yeou Kim, Yunsook Lim
In this study, we investigated the protective effects of SM on skeletal muscle and brain damage by regulation of BDNF/ PGC1α/irisin pathway via brain function related myokines in high-fat diet-induced OB mice. OB was induced by high-fat diet for 6 weeks. SM extract (SME) was administered with 200 mg/kg BW (LSM) and 500 mg/kg BW (HSM) by oral gavage every day for 12 weeks. Behavior tests such as grip
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Predictive model for vitamin C levels in hyperinsulinemic individuals based on age, sex, waist circumference, low-density lipoprotein, and immune-associated serum proteins J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-11-27 Atena Mahdavi, Mickaël Leclercq, Arnaud Droit, Iwona Rudkowska, Michel Lebel
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Vitamin B12-folic acid supplementation improves memory by altering mitochondrial dynamics, dendritic arborization, and neurodegeneration in old and amnesic male mice J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-11-20 Ela Mishra, Mahendra Kumar Thakur
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Advances in the study of vascular related protective effect of garlic (Allium sativum) extract and compounds J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-11-19 Mengkai Lu, Jinyuan Pan, Yuanlong Hu, Liang Ding, Yuan Li, Xinhai Cui, Muxin Zhang, Zhiyuan Zhang, Chao Li
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Folic acid blocks ferroptosis induced by cerebral ischemia and reperfusion through regulating Folate hydrolase transcriptional adaptive program J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-11-17 Peng Wang, Yangyang Huang, Buxun Sun, Hongpeng Chen, YiFan Ma, Yuhang Liu, Tao Yang, Hongbo Jin, Yuandong Qiao, Yongggang Cao
Cerebral ischemia-reperfusion (I/R) injury is notably linked with folic acid (FA) deficiency. The aim of our investigation was to explore the effects and underlying mechanisms by which FA mitigates I/R, specifically through regulating the GCPII transcriptional adaptive program. Initially, we discovered that following cerebral I/R, levels of FA, methionine synthase (MTR), and methylenetetrahydrofolate
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Raspberry Polyphenols Target Molecular Pathways of Heart Failure J. Nutr. Biochem. (IF 5.6) Pub Date : 2023-11-19 Rami S. Najjar, Ranjan K. Roy, Javier E. Stern, Rafaela G. Feresin
Approximately 650,000 new cases of heart failure (HF) are diagnosed annually with a 50% five-year mortality rate. HF is characterized by reduced left ventricular (LV) ejection fraction and hypertrophy of the LV wall. The pathophysiological remodeling of the heart is mediated by increased oxidative stress and inflammation. Raspberries are rich in polyphenols which may favorably impact enzymes involved