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miR-34a/TAN1/CREB Axis Engages in Alleviating Oligodendrocyte Trophic Factor-Induced Myelin Repair Function and Astrocyte-Dependent Neuroinflammation in the Early Stages of Alzheimer's Disease: The Anti-Neurodegenerative Effect of Treadmill Exercise Neurochem. Res. (IF 4.4) Pub Date : 2024-04-01
Abstract Reduced myelin stability observed in the early stages of Alzheimer's disease leads to spatial learning and memory impairment. Exercise has been shown to protect nerves, reduce the risk of Alzheimer's disease, and strengthen synaptic connectivity. However, the underlying mechanisms of how exercise can promote myelin repair and coordinate inflammation and proliferation are still uncertain. In
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MM165 - A Small Hybrid Molecule Modulates the Kynurenine Pathway and Attenuates Lipopolysaccharide-Induced Memory Deficits and Inflammation Neurochem. Res. (IF 4.4) Pub Date : 2024-02-21 Magdalena Kotańska, Michał Łanocha, Marek Bednarski, Monika Marcinkowska
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Stroke and Distal Organ Damage: Exploring Brain-Kidney Crosstalk Neurochem. Res. (IF 4.4) Pub Date : 2024-02-20 Vandana Dulam, Sireesha Katta, Venkata Prasuja Nakka
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Modulation of Pyruvate Export and Extracellular Pyruvate Concentration in Primary Astrocyte Cultures Neurochem. Res. (IF 4.4) Pub Date : 2024-02-20
Abstract Astrocyte-derived pyruvate is considered to have neuroprotective functions. In order to investigate the processes that are involved in astrocytic pyruvate release, we used primary rat astrocyte cultures as model system. Depending on the incubation conditions and medium composition, astrocyte cultures established extracellular steady state pyruvate concentrations in the range between 150 µM
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Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats Neurochem. Res. (IF 4.4) Pub Date : 2024-02-18 Antonio Girella, Martina Di Bartolomeo, Enrico Dainese, Valeria Buzzelli, Viviana Trezza, Claudio D’Addario
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Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury Neurochem. Res. (IF 4.4) Pub Date : 2024-02-16 Wei Mao, Feng Jiang, Chunping Zhu, Jun Liu, Zhao Lu, Yinwei Qian, Jinchun Xiao
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Egg White Hydrolysate Mitigates Cadmium-induced Neurological Disorders and Oxidative Damage Neurochem. Res. (IF 4.4) Pub Date : 2024-02-14 José Eudes Gomes Pinheiro Júnior, Priscila Marques Sosa, Ben-Hur Souto das Neves, Dalton Valentim Vassallo, Franck Maciel Peçanha, Marta Miguel-Castro, Pâmela Billig Mello-Carpes, Giulia Alessandra Wiggers
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Epidermal Growth Factor Suppresses the Development of GABAergic Neurons Via the Modulation of Perineuronal Net Formation in the Neocortex of Developing Rodent Brains Neurochem. Res. (IF 4.4) Pub Date : 2024-02-14 Yuriko Iwakura, Yutaro Kobayashi, Hisaaki Namba, Hiroyuki Nawa, Nobuyuki Takei
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Exogenous Substrates Prevent the Decline in the Cellular ATP Content of Primary Rat Astrocytes During Glucose Deprivation Neurochem. Res. (IF 4.4) Pub Date : 2024-02-11 Antonia Regina Harders, Paul Spellerberg, Ralf Dringen
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A Review of Cerebrospinal Fluid Circulation and the Pathogenesis of Congenital Hydrocephalus Neurochem. Res. (IF 4.4) Pub Date : 2024-02-10
Abstract The brain’s ventricles are filled with a colorless fluid known as cerebrospinal fluid (CSF). When there is an excessive accumulation of CSF in the ventricles, it can result in high intracranial pressure, ventricular enlargement, and compression of the surrounding brain tissue, leading to potential damage. This condition is referred to as hydrocephalus. Hydrocephalus is classified into two
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Electroacupuncture Alleviates Pain by Suppressing P2Y12R-Dependent Microglial Activation in Monoarthritic Rats Neurochem. Res. (IF 4.4) Pub Date : 2024-02-10
Abstract Electroacupuncture (EA) effectively improves arthritis-induced hyperalgesia and allodynia by repressing spinal microglial activation, which plays a crucial role in pain hypersensitivity following tissue inflammation. However, the mechanism by which EA suppresses spinal microglial activation in monoarthritis (MA) remains unclear. In the present study, a rat model of MA was established through
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Pretreatment with Liposome-Encapsulated Shrimp Shell Extract Attenuated Neuronal Damage and Death in Aβ1-42-Induced Memory Deficits in Rats Neurochem. Res. (IF 4.4) Pub Date : 2024-02-07 Zulkiflee Kuedo, Thunwa Binlateh, Soottawat Benjakul, Pilaiwanwadee Hutamekalin
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Sulphated Fucooligosaccharide from Sargassum Horneri: Structural Analysis and Anti-Alzheimer Activity Neurochem. Res. (IF 4.4) Pub Date : 2024-02-02 Ling-Jian Zhang, Hao-Zheng Zhang, Ya-Wen Liu, Min Tang, Yong-Jun Jiang, Fu-Nan Li, Li-Ping Guan, Qing-Hao Jin
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7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia Neurochem. Res. (IF 4.4) Pub Date : 2024-02-01
Abstract Vascular dementia (VD) is a degenerative cerebrovascular disorder associated with progressive cognitive decline. Previous reports have shown that 7,8-dihydroxyflavone (7,8-DHF), a well-known TrkB agonist, effectively ameliorates cognitive deficits in several disease models. Therefore, this study investigated the protective effects of 7,8-DHF against 2-VO-induced VD. VD was established in rats
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The Progress of Poststroke Seizures Neurochem. Res. (IF 4.4) Pub Date : 2024-01-31 Cong Xie, Wei Zhao, Xu Zhang, Ju Liu, Jinzhi Liu, Zhangyong Xia
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Sericin Improves Memory Impairment Via Activation of the PKA-CREB-BDNF Signaling Pathway and Suppression of Oxidative Stress in Ovariectomized Mice Neurochem. Res. (IF 4.4) Pub Date : 2024-01-30 Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Seyedmahdi Vatandoust, Leila Hosseini, Soroush Morsali, Hamidreza Feizi, Pedram Ghaderi Shadbad, Javad Mahmoudi
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Transient Receptor Potential Channels: Multiple Modulators of Peripheral Neuropathic Pain in Several Rodent Models Neurochem. Res. (IF 4.4) Pub Date : 2024-01-28 Songchao Xu, Yun Wang
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Diphenyl Diselenide Through Reduction of Inflammation, Oxidative Injury and Caspase-3 Activation Abates Doxorubicin-Induced Neurotoxicity in Rats Neurochem. Res. (IF 4.4) Pub Date : 2024-01-24 Oluwatobiloba F. Da-silva, Adedoyin R. Adelowo, Adesina A. Babalola, Cynthia N. Ikeji, Olatunde Owoeye, Joao B. T. Rocha, Isaac A. Adedara, Ebenezer O. Farombi
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Liraglutide Reduces Alcohol Consumption, Anxiety, Memory Impairment, and Synapse Loss in Alcohol Dependent Mice Neurochem. Res. (IF 4.4) Pub Date : 2024-01-24 Weizhen Liu, Ziliang Wang, Wang Wang, Zhiju Wang, Ying Xing, Christian Hölscher
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Protective Effects of Glatiramer Acetate Against Paclitaxel-Induced Peripheral Neuropathy in Rats: A Role for Inflammatory Cytokines and Oxidative Stress Neurochem. Res. (IF 4.4) Pub Date : 2024-01-22 Sajad Dekamin, Mehdi Ghasemi, Ahmad Reza Dehpour, Mahmoud Ghazi-Khansari, Hamed Shafaroodi
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Gut-Brain Axis Modulation of Metabolic Disorders: Exploring the Intertwined Neurohumoral Pathways and Therapeutic Prospects Neurochem. Res. (IF 4.4) Pub Date : 2024-01-20 Diya Bhalla, Susha Dinesh, Sameer Sharma, Gonchigar Jayanna Sathisha
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The Role of IL-6 in Neurodegenerative Disorders Neurochem. Res. (IF 4.4) Pub Date : 2024-01-16 Chen Shan, Chao Zhang, Chuanbao Zhang
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The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity Neurochem. Res. (IF 4.4) Pub Date : 2024-02-01 Jie Gao, Wei Liu, Jiaqi Liu, Niping Hao, Jing Pei, Lifeng Zhang
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RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury Neurochem. Res. (IF 4.4) Pub Date : 2024-02-01 Lvxia Wang, Yong Zhang, Min Huang, Yiling Yuan, Xuehong Liu
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Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation Neurochem. Res. (IF 4.4) Pub Date : 2024-02-01 Shahrzad Molavinia, Mehrad Nikravesh, Marzieh Pashmforoosh, Hossein Rajabi Vardanjani, Mohammad Javad Khodayar
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Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations Neurochem. Res. (IF 4.4) Pub Date : 2024-01-10 Mumin Alper Erdogan, Orkun Gurbuz, Mehmet Fatih Bozkurt, Oytun Erbas
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Azilsartan Attenuates 3-Nitropropinoic Acid-Induced Neurotoxicity in Rats: The Role of IĸB/NF-ĸB and KEAP1/Nrf2 Signaling Pathways Neurochem. Res. (IF 4.4) Pub Date : 2024-01-07 Hend A. Hamouda, Rabab H. Sayed, Nihad I. Eid, Bahia M. El-Sayeh
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Shank3 Deficiency Results in a Reduction in GABAergic Postsynaptic Puncta in the Olfactory Brain Areas Neurochem. Res. (IF 4.4) Pub Date : 2024-01-06 Denisa Mihalj, Veronika Borbelyova, Zdeno Pirnik, Zuzana Bacova, Daniela Ostatnikova, Jan Bakos
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Attenuation of Streptozotocin-Induced Diabetic Neuropathic Allodynia by Flavone Derivative Through Modulation of GABA-ergic Mechanisms and Endogenous Biomarkers Neurochem. Res. (IF 4.4) Pub Date : 2024-01-03
Abstract Diabetic neuropathic pain is one of the most devasting disorders of peripheral nervous system. The loss of GABAergic inhibition is associated with the development of painful diabetic neuropathy. The current study evaluated the potential of 3-Hydroxy-2-methoxy-6-methyl flavone (3-OH-2′MeO6MF), to ameliorate peripheral neuropathic pain using an STZ-induced hyperglycemia rat model. The pain threshold
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SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke Neurochem. Res. (IF 4.4) Pub Date : 2024-01-03 Jian Li, Gao Wei, Zhaoming Song, Zhouqing Chen, Jingyu Gu, Li Zhang, Zhong Wang
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A New Perspective in the Treatment of Ischemic Stroke: Ferroptosis Neurochem. Res. (IF 4.4) Pub Date : 2024-01-03 Lei Zhang, Xin Yue Bai, Ke Yao Sun, Xuan Li, Zhao Qi Zhang, Yi Ding Liu, Yang Xiang, Xiao Long Liu
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METTL3-deficiency Suppresses Neural Apoptosis to Induce Protective Effects in Cerebral I/R Injury via Inhibiting RNA m6A Modifications: A Pre-clinical and Pilot Study Neurochem. Res. (IF 4.4) Pub Date : 2024-01-01 Gang Huang, Yuda Qiu, Yafei Fan, Jianfeng Liu
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Purmorphamine, a Smo-Shh/Gli Activator, Promotes Sonic Hedgehog-Mediated Neurogenesis and Restores Behavioural and Neurochemical Deficits in Experimental Model of Multiple Sclerosis Neurochem. Res. (IF 4.4) Pub Date : 2023-12-30 Aradhana Prajapati, Sidharth Mehan, Zuber Khan, Swesha Chhabra, Ghanshyam Das Gupta
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The Pulsed Nd:YAG Laser Therapy Enhanced Nerve Regeneration via Apoptosis Inhibition in a Rat Crushed Sciatic Nerve Model Neurochem. Res. (IF 4.4) Pub Date : 2023-12-29 Po-Yen Ko, Che-Chia Hsu, Shih-Yao Chen, Chia-Lung Li, I-Ming Jou, Po-Ting Wu
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Differential Effects of Neonatal Ventral Hippocampus Lesion on Behavior and Corticolimbic Plasticity in Wistar–Kyoto and Spontaneously Hypertensive Rats Neurochem. Res. (IF 4.4) Pub Date : 2023-12-29 Hiram Tendilla-Beltrán, Linda Garcés-Ramírez, Edwin Martínez-Vásquez, Andrea Nakakawa, Ma de Jesús Gómez-Villalobos, Gonzalo Flores
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Cannabidiol and Tetrahydrocannabinol Antinociceptive Activity is Mediated by Distinct Receptors in Caenorhabditis elegans Neurochem. Res. (IF 4.4) Pub Date : 2023-12-23 Fatma Boujenoui, Bruno Nkambeu, Jennifer Ben Salem, Jesus David Castano Uruena, Francis Beaudry
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Neuroprotective and Anti-inflammatory Effects of Rubiscolin-6 Analogs with Proline Surrogates in Position 2 Neurochem. Res. (IF 4.4) Pub Date : 2023-12-20 Renata Perlikowska, Joana Silva, Celso Alves, Patricia Susano, Małgorzata Zakłos-Szyda, Agnieszka Skibska, Anna Adamska-Bartłomiejczyk, Karol Wtorek, Jean-Claude do Rego, Jean-Luc do Rego, Alicja Kluczyk, Rui Pedrosa
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Transcranial Irradiation Mitigates Paradoxical Sleep Deprivation Effect in an Age-Dependent Manner: Role of BDNF and GLP-1 Neurochem. Res. (IF 4.4) Pub Date : 2023-12-20 Radwa H. Lutfy, Amina E. Essawy, Haitham S. Mohammed, Marwa M. Shakweer, Sherine Abdel Salam
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Non-coding RNAs and Aquaporin 4: Their Role in the Pathogenesis of Neurological Disorders Neurochem. Res. (IF 4.4) Pub Date : 2023-12-19 Zahra Yaghoobi, Shahrzad Sadat Seyed Bagher Nazeri, Amir Asadi, Ehsan Derafsh, Abdolkarim Talebi Taheri, Zeinab Tamtaji, Ehsan Dadgostar, Fatemeh Rahmati-Dehkordi, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji, Fatemeh Nabavizadeh
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Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4 Neurochem. Res. (IF 4.4) Pub Date : 2023-12-19 Naoya Fukuda, Kohki Toriuchi, Rina Mimoto, Hiromasa Aoki, Hiroki Kakita, Yoshiaki Suzuki, Satoru Takeshita, Tetsuya Tamura, Hisao Yamamura, Yasumichi Inoue, Hidetoshi Hayashi, Yasumasa Yamada, Mineyoshi Aoyama
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Relationship of Sleep Disorder with Neurodegenerative and Psychiatric Diseases: An Updated Review Neurochem. Res. (IF 4.4) Pub Date : 2023-12-18 Xiao Xiao, Yimin Rui, Yu Jin, Ming Chen
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Memantine Improves Memory and Neurochemical Damage in a Model of Maple Syrup Urine Disease Neurochem. Res. (IF 4.4) Pub Date : 2023-12-16 Isabela da Silva Lemos, Carolina Antunes Torres, Carolina Giassi Alano, Rafaela Tezza Matiola, Rejane de Figueiredo Seldenreich, Alex Paulo Zeferino Padilha, Ellen De Pieri, Pauline Souza Effting, Ricardo Andrez Machado-De-Ávila, Gislaine Zilli Réus, Guilhian Leipnitz, Emilio Luiz Streck
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Nitronyl Nitroxide Ameliorates Hypobaric Hypoxia-Induced Cognitive Impairment in Mice by Suppressing the Oxidative Stress, Inflammatory Response and Apoptosis Neurochem. Res. (IF 4.4) Pub Date : 2023-12-16
Abstract Abundant investigations have shown that hypobaric hypoxia (HH) causes cognitive impairment, mostly attributed to oxidative stress, inflammation, and apoptosis. HPN (4′-hydroxyl-2-subsitiuted phenylnitronyl nitroxide) is an excellent free radical scavenger with anti-inflammatory and anti-apoptotic activities. Our previous study has found that HPN exhibited neuroprotective effect on HH induced
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Lateral Habenula Neurons Signal Cold Aversion and Participate in Cold Aversion Neurochem. Res. (IF 4.4) Pub Date : 2023-12-16 Rui Liu, Huan Xiang, Chunyang Liu, Qiuyi Jiang, Yanchao Liang, Guangzheng Wang, Lu Wang, Yi Sun, Guang Yang
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The Impact of Dipyridamole on Disease-Associated Microglia Phenotypic Transformation in White Matter Lesions Induced by Chronic Cerebral Hypoperfusion Neurochem. Res. (IF 4.4) Pub Date : 2023-12-15 Wenchao Cheng, Yuhan Wang, Lan Zhang, Chang Cheng, Xiuying Chen, Wen Huang
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Multifaceted Neuroprotective Role of Punicalagin: A Review Neurochem. Res. (IF 4.4) Pub Date : 2023-12-12 Nazia Siddiqui, Alimuddin Saifi, Anurag Chaudhary, Prabhash Nath Tripathi, Ankit Chaudhary, Alok Sharma
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CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets Neurochem. Res. (IF 4.4) Pub Date : 2023-12-08 Xiao-Ling Chen, Quan-Dan Tan, Ke-Jie Chen, Dan-Ni Zheng, Hong-Wei Deng, Song He, Feng-Kai Mao, Jun-Li Hao, Wei-Dong Le, Jie Yang
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Transplantation of Neural Stem Cells-Overexpressed Ku70 Improves Neurological Deficits in a Mice Model of Cerebral Ischemia Stroke Neurochem. Res. (IF 4.4) Pub Date : 2023-12-08 Hui Liu, Chonghua Jiang, Jun Peng, Xiqi Hu, Ying Xia
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Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout mice Neurochem. Res. (IF 4.4) Pub Date : 2023-12-08 Larissa Daniele Bobermin, Patrícia Sesterheim, Daniele Schauren da Costa, Ester Rezena, Izaviany Schmitz, Amanda da Silva, Aline Daniel Moreira de Moraes, Diogo Onofre Souza, Angela TS Wyse, Guilhian Leipnitz, Carlos Alexandre Netto, André Quincozes-Santos, Carlos-Alberto Gonçalves
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HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells Neurochem. Res. (IF 4.4) Pub Date : 2023-12-06 Chunlu Zhang, Xi Chen, Ruizhu Liu, Guoqing Zhao
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Narirutin Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing the TXNIP/NLRP3 Pathway Neurochem. Res. (IF 4.4) Pub Date : 2023-12-04 Li Luo, Saiying Wang, Wenna Liu, Zimei Zhang, Minggao Zhao, An Liu
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Pathogenesis of Depression in Alzheimer’s Disease Neurochem. Res. (IF 4.4) Pub Date : 2023-11-28 Qingyang Zhan, Fanyi Kong, Shuai Shao, Bo Zhang, Shuming Huang
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Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy Neurochem. Res. (IF 4.4) Pub Date : 2023-11-29 Miguel Ángel Velázquez-Flores, Gustavo Sánchez-Chávez, Sara L. Morales-Lázaro, Ruth Ruiz Esparza-Garrido, Alejandro Canizales-Ontiveros, Rocío Salceda
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Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia Neurochem. Res. (IF 4.4) Pub Date : 2023-11-28 Zhongni Li, Feng Zhang, Li Huang, Jiehong Deng, Yutong Pan, Ting Xu, Jingyi Liu, Na Gao, Rongrong Duan, Chunyan Shao, Chan Wu, Minrong Wang, Liqun Lu
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Hexavalent Chromium Induces Neurotoxicity by Triggering Mitochondrial Dysfunction and ROS-Mediated Signals Neurochem. Res. (IF 4.4) Pub Date : 2023-11-27 Tongtong Zhang, Lina Feng, Jie Cui, Weiwei Tong, Han Zhao, Tingchao Wu, Pu Zhang, Xianjun Wang, Yingjun Gao, Jing Su, Xiaoyan Fu
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Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats Neurochem. Res. (IF 4.4) Pub Date : 2023-11-27 Zohreh Ghotbeddin, Mohsen Peysokhan, Anahita Memar Dezfouli, Mohammad Asadi Iraee
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The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy. Neurochem. Res. (IF 4.4) Pub Date : 2023-11-25 Raed AlRuwaili,Hayder M Al-Kuraishy,Ali I Al-Gareeb,Naif H Ali,Athanasios Alexiou,Marios Papadakis,Hebatallah M Saad,Gaber El-Saber Batiha
Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of epileptogenesis and epilepsy, BDNF may have a neuroprotective effect against epilepsy. Thus, the goal of the present review was to highlight the protective and detrimental roles of BDNF in epilepsy. In this review, we also try to find
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Acrylamide, Applied During Pregnancy and Postpartum Period in Offspring Rats, Significantly Disrupted Myelination by Decreasing the Levels of Myelin-Related Proteins: MBP, MAG, and MOG Neurochem. Res. (IF 4.4) Pub Date : 2023-11-21 Muhammed Mehdi Üremiş, Nuray Üremiş, Mehmet Gül, Semir Gül, Yılmaz Çiğremiş, Merve Durhan, Yusuf Türköz
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Modulation of DOM-Induced Head-Twitch Response by mGluR2 Agonist/Inverse Agonist is Associated with 5-HT2AR-Mediated Gs Signaling Pathway Neurochem. Res. (IF 4.4) Pub Date : 2023-11-21 Huan Gao, Xiaoqian Liu, Lulu Xie, Bo Tan, Ruibin Su
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Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion Neurochem. Res. (IF 4.4) Pub Date : 2023-11-17 Yuhan Wang, Wenchao Cheng, Xiuying Chen, Chang Cheng, Lan Zhang, Wen Huang