样式: 排序: IF: - GO 导出 标记为已读
-
Acute MK-801 increases measures of both sign-tracking and goal-tracking in male Sprague-Dawley rats Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-03-04 John Michael Holden, Amanda Barbaro, Kiya Azure, Megan Arth
Sign-tracking is a Pavlovian conditioned approach behavior thought to be important in understanding cue-driven relapse to drug use, and strategies for reducing sign-tracking may have some benefit in preventing relapse. A previous study successfully employed the NMDA receptor antagonist MK-801 in preventing the development of sign-tracking (but not goal-tracking) in a conditioned approach task. In this
-
Adolescent alcohol exposure modifies adult anxiety-like behavior and amygdala sensitivity to alcohol in rats: Increased c-Fos activity and sex-dependent microRNA-182 expression Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-03-02 Ana Vázquez-Ágredos, Marta Valero, Teresa Aparicio-Mescua, Raquel García-Rodríguez, Fernando Gámiz, Milagros Gallo
Adolescent binge alcohol drinking is a serious health concern contributing to adult alcohol abuse often associated with anxiety disorders. We have used adolescent intermittent ethanol (AIE) administration as a model of binge drinking in rats in order to explore its long-term effect on the basolateral amygdala (BLA) responsiveness to alcohol and anxiety-like behavior. AIE increased the number of BLA
-
A role of gut–brain axis on prophylactic actions of arketamine in male mice exposed to chronic restrain stress Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-02-23 Li Ma, Akifumi Eguchi, Guilin Liu, Youge Qu, Xiayun Wan, Rumi Murayama, Chisato Mori, Kenji Hashimoto
The gut–brain axis, which includes gut microbiota and microbiome-derived metabolites, might be implicated in depression. We reported the sustained prophylactic effects of a new antidepressant arketamine in chronic restrain stress (CRS) model of depression. In this study, we investigated the role of gut–brain axis on the prophylactic effects of arketamine in the CRS (7 days) model. Pretreatment with
-
-
Zuranolone, a neuroactive drug, used in the treatment of postpartum depression by modulation of GABAA receptors Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-02-20 Renu Sharma, Pranjal Bansal, Lokesh Saini, Nidhi Sharma, Richa Dhingra
Postpartum depression [PPD] is a prevalent and debilitating mood disorder that affects mothers in the weeks to months after childbirth. Zuranolone (Zurzuvae) is a novel pharmaceutical agent that was approved by the US FDA on 4 August 2023 for the management of PPD. This review article provides a comprehensive overview of zuranolone, focusing on its dosing, chemistry, mechanism of action, clinical trials
-
Enantiomeric contributions to methamphetamine's bidirectional effects on basal and fentanyl-depressed respiration in mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-02-17 Harrison J. Elder, D. Matthew Walentiny, Patrick M. Beardsley
Fentanyl remains the primary cause of fatal overdoses, and its co-use with methamphetamine (METH) is a growing concern. We previously demonstrated that racemic METH can either enhance or mitigate opioid-induced respiratory depression (OIRD) dependent upon whether a low or high dose is administered. The optical isomers of METH, dextromethamphetamine (METH) and levomethamphetamine (METH), differ substantially
-
Paraventricular thalamus to nucleus accumbens circuit activation decreases long-term relapse of alcohol-seeking behaviour in male mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-02-13 Xiaoxi Zhao, Aqian Hu, Yanyan Wang, Tianshu Zhao, Xiaojun Xiang
Some studies have highlighted the crucial role of aversion in addiction treatment. The pathway from the anterior paraventricular thalamus (PVT) to the shell of the nucleus accumbens (NAc) has been reported as an essential regulatory pathway for processing aversion and is also closely associated with substance addiction. However, its impact on alcohol addiction has been relatively underexplored. Therefore
-
Preliminary investigation of the administration of biperiden to reduce relapses in individuals with cocaine/crack user disorder: A randomized controlled clinical trial Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-02-09 Miguel Siqueira Campos Junior, Andréia Gomes Bezerra, Daniela Fernández Curado, Renata Pauluci Gregório, José Carlos Fernandes Galduróz
Several studies have demonstrated that ACh modulates the dopaminergic circuit in the nucleus accumbens, and its blockade appears to be associated with the inhibition of the reinforced effect or the increase in dopamine caused by cocaine use. The objective of this study was to evaluate the effect of biperiden (a muscarinic receptor antagonist with a relatively higher affinity for the M1 receptor) on
-
Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-02-08 Jia-Ya Zheng, Xue-Xin Li, Xiao Liu, Chen-Chen Zhang, Ya-Xin Sun, Yu-Nu Ma, Hong-Li Wang, Yun-Ai Su, Tian-Mei Si, Ji-Tao Li
The sex difference that females are more vulnerable to depression than males has been recently replicated in an animal model of early-life stress (ES) called the limited bedding and nesting material (LBN) paradigm. Adopting this animal model, we have previously examined the effects of ES on monoamine transporter (MATs) expression in stress-related regions in adult female mice, and the reversal effects
-
Altered reward sensitivity to sucrose outcomes prior to drug exposure in alcohol preferring rats Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-02-08 Justin J. McGraw, Robert S. Goldsmith, Howard C. Cromwell
Addiction involves key impairments in reward sensitivity (RS). The current study explored impaired RS to natural reward as a predisposing factor to addictive-like behavior. Alcohol preferring (P) rats are selectively bred based on significantly greater ethanol consumption and preference and offer the ability to inspect differences in subjects with a positive family history of addictive-like behavior
-
The alpha-7 nicotinic acetylcholine receptor agonist PHA-543613 reduces food intake in male rats Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-02-07 Adrianne M. DiBrog, Katherine A. Kern, Emily Demieri, Elizabeth G. Mietlicki-Baase
Obesity is a prevalent disease, but effective treatment options remain limited. Agonists of the alpha-7 nicotinic acetylcholine receptor (α7nAChR) promote negative energy balance in mice, but these effects are not well-studied in rats. We tested the hypothesis that central administration of the α7nAChR agonist PHA-543613 (PHA) would decrease food intake and body weight in adult male Sprague Dawley
-
Ameliorating effect of pioglitazone on prenatal valproic acid-induced behavioral and neurobiological abnormalities in autism spectrum disorder in rats Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-02-02 Arushi Sandhu, Kajal Rawat, Vipasha Gautam, Alka Bhatia, Sandeep Grover, Lokesh Saini, Lekha Saha
-
Differential disruption of response alternation by precipitated Δ9-THC withdrawal and subsequent Δ9-THC abstinence in mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-01-23 Matthew L. Eckard, Steven G. Kinsey
In addition to overt somatic symptoms, cannabinoid withdrawal can also manifest as disruptions in motivation and attention. Experimental animal models using operant-conditioning approaches reveal these differences, in either antagonist-precipitated or spontaneous withdrawal models. However, these processes have yet to be characterized in the same subjects simultaneously. To differentiate between motivational
-
Region-specific alterations in the expression and phosphorylation of NMDA receptor subunits in the rat prefrontal cortex and dorsal striatum accompanying behavioral sensitization induced by cocaine and ethanol Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-01-20 Shijie Xu, Ung Gu Kang
Behavioral sensitization is defined as the enhanced behavioral response to drugs of abuse after repeated exposure, which can serve as a behavioral model of addiction. Our previous study demonstrated that behavioral cross-sensitization occurs between cocaine and ethanol, suggesting commonalities between these drugs. N-methyl-d-aspartate (NMDA) receptors play important roles in synaptic plasticity, learning
-
-
Physical activity as a promoter of stress resilience: An analysis of behavioral effects and brain connectivity with cytochrome c-oxidase activity in adult male Wistar rats Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-01-18 Azucena Begega, Matías López, Ignacio Cuesta-López, Claudia I. Jove, Marcelino Cuesta Izquierdo
-
Alpha1- and Beta-norepinephrinergic receptors of dorsomedial and ventromedial hypothalamic nuclei modulate panic attack-like defensive behaviour elicited by diencephalic GABAergic neurotransmission disinhibition Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-01-21 Andrés Uribe-Mariño, Luiz Luciano Falconi-Sobrinho, Maria Angélica Castiblanco-Urbina, Glauce Regina Pigatto, Farhad Ullah, Juliana Almeida da Silva, Norberto Cysne Coimbra
-
Somatic and anxiety-like behaviors in male and female rats during withdrawal from the non-selective cannabinoid agonist WIN 55,212–2 Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-01-18 Abigail L. Brewer, Claire E. Felter, Anna R. Sternitzky, Sade M. Spencer
Synthetic cannabinoids are associated with higher risk of dependence and more intense withdrawal symptoms than plant-derived Δ9-tetrahydrocannabinol (THC). Avoidance of withdrawal symptoms, including anxiogenic effects, can contribute to continued cannabinoid use. Adult male and female Long-Evans rats were given escalating doses of WIN 55,212–2 (WIN) via twice daily intrajugular infusions. Precipitated
-
Impulsivity and aggression in alcohol withdrawal syndrome is modulated by the interaction of ZNF804A and mTOR polymorphism Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-01-10 Guanghui Shen, Yuyu Wu, Kexin Wang, Michelle Niculescu, Yuqing Liu, Yimin Kang, Xingguang Luo, Wei Wang, Yu-Hsin Chen, Yanlong Liu, Fan Wang, Li Chen
Alcohol withdrawal syndrome (AWS) is a poorly studied phenotype of alcohol use disorder. Understanding the relationship between allelic interactions and AWS-related impulsivity and aggression could have significant implications. This study aimed to investigate the main and interacting effects of ZNF804A and mTOR on impulsivity and aggression during alcohol withdrawal. 446 Chinese Han adult males with
-
Signaling pathways and genetics of brain Renin angiotensin system in psychiatric disorders: State of the art Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2024-01-02 Roya Barak, Ghazal Goshtasbi, Reihaneh Fatehi, Negar Firouzabadi
-
Established sensitization of ethanol-induced locomotor activity is not reversed by psilocybin or the 5-HT2A receptor agonist TCB-2 in male DBA/2J mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-12-27 Paul J. Fletcher, Zhaoxia Li, Xiao Dong Ji, Anh D. Lê
Rationale Psychedelic drugs, which share in common 5-HT2A receptor agonist activity, have shown promise in treating alcohol-use disorders (AUDs). Repeated exposure to ethanol (EtOH) induces molecular and behavioural changes reflective of neuroadaptations that may contribute to addiction. Psychedelic drugs can induce neuroplasticity also, raising the possibility that their potential clinical effects
-
Varenicline but not cotinine increased the value of a visual stimulus reinforcer in rats: No evidence for synergy of the two compounds Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-12-27 Sydney D. Houser, Kathleen R. McNealy, Scott T. Barrett, Rick A. Bevins
Smoking is the leading cause of preventable death worldwide, with <7 % of smoking cessation attempts being met with success. Nicotine, the main addictive agent in cigarettes, enhances the reinforcing value of other environmental rewards. Under some circumstances, this reward enhancement maintains nicotine consumption. Varenicline (i.e., cessation aid Chantix™) also has reward-enhancement effects via
-
Relationship between sphingolipids-mediated neuroinflammation and alcohol use disorder Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-12-19 XiaoJian Cui, JiaZhen Li, ChuanSheng Wang, Hafiz Muhammad Ishaq, RuiLin Zhang, Fan Yang
Background Alcohol use disorder is a chronic recurrent encephalopathy, and its pathogenesis has not been fully understood. Among possible explanations, neuroinflammation caused by the disorders of brain central immune signaling has been identified as one possible mechanism of alcohol use disorder. As the basic components of cells and important bioactive molecules, sphingolipids are essential in regulating
-
Distinct antinociceptive and conditioned behavioral effects are produced by individual cannabinoids and a cannabis-derived mixture Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-12-19 Tamara Morris, Jessica A. Cucinello-Ragland, Taylor J. Marks, Kayla Prevost, John F. Glenn, Gregory J. Davenport, Scott Edwards, Peter J. Winsauer
Cannabinoids have been proposed as therapeutics for pain mitigation. Therefore, the antihyperalgesic effects of a proprietary cannabis-derived mixture, Non-Euphoric Phytocannabinoid Elixir #14 (NEPE14), were examined in a persistent Complete Freund's Adjuvant (CFA)-induced model of inflammatory pain. The acute antinociceptive and operant behavioral effects of NEPE14 were then compared with single cannabinoid
-
Cold nociception as a measure of hyperalgesia during spontaneous heroin withdrawal in mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-12-20 Lyndsay E. Hastings, Emma V. Frye, Erika R. Carlson, Vicky Chuong, Aniah N. Matthews, George F. Koob, Leandro F. Vendruscolo, Renata C.N. Marchette
Opioids are powerful analgesic drugs that are used clinically to treat pain. However, chronic opioid use causes compensatory neuroadaptations that result in greater pain sensitivity during withdrawal, known as opioid withdrawal-induced hyperalgesia (OWIH). Cold nociception tests are commonly used in humans, but preclinical studies often use mechanical and heat stimuli to measure OWIH. Thus, further
-
Shifts in stimulus control over opioid use with increasing periods of recovery Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-12-15 Hanana AlTfaili, R.J. Lamb, Brett C. Ginsburg
Background Periods of engaging in an alternative behavior diminishes behavioral control by stimuli occasioning alcohol use. This increase in relapse resistance with increasing recovery suggests that changing stimulus control over substance use may be a mechanism responsible for decreased relapse rates with longer recovery. However, the generality of this phenomenon to other drugs of abuse, including
-
Reducing sugar intake through chronic swimming training: Exploring palatability changes and central vasopressin mechanisms Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-12-09 Marcone Rodrigues da Silva e Santos, Milede Hanner Paes, Renata Cristina Queiroz Silva Bento, Leonardo Máximo Cardoso, Lisandra Brandino de Oliveira
Excessive sugar intake has been associated with the onset of several non-communicable chronic diseases seen in humans. Physical activity could affect sweet taste perception which may affect sugar intake. Therefore, it was investigated the chronic effects of swimming training on sucrose intake/preference, reactivity to sucrose taste, self-care in neurobehavioral stress, and the possible involvement
-
Memantine and SKF82958 but not an enriched environment modulate naloxone-precipitated morphine abstinence syndrome without affecting hippocampal tPA mRNA levels in rats Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-12-04 Abdurrahman Aslan, Özden Hatırnaz-Ng, Orçun Taşar, Uğur Özbek, Pınar Yamantürk-Çelik
There is accumulating evidence supporting the involvement of tissue-plasminogen activator (tPA) in the mechanisms underlying the effects of morphine and an enriched environment. This study was designed to investigate possible interactive roles of the glutamatergic and the dopaminergic systems regarding hippocampal tPA in the neurobiology of morphine dependence. For this purpose, Wistar albino rats
-
The orexin receptor 2 (OX2R)-selective agonist TAK-994 increases wakefulness without affecting cerebrospinal fluid orexin levels in cynomolgus monkeys Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-12-06 Ryuji Yamada, Naohiro Narita, Takashi Ishikawa, Masaaki Kakehi, Haruhide Kimura
Orexin A (OX-A) and orexin B are neuropeptides produced in orexin neurons located in the lateral hypothalamus that exert multiple biological functions through the activation of orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R) throughout the central nervous system. OX1R and OX2R have distinct functions: OX1R is involved in reward seeking, whereas OX2R has a pivotal role in sleep/wake regulation
-
Ndufs4 KO mice: A model to study comorbid mood disorders associated with mitochondrial dysfunction Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-12-07 Daniël J. van Rensburg, Zander Lindeque, Brian H. Harvey, Stephan F. Steyn
The Ndufs4 knockout (KO) mouse is a validated and robust preclinical model of mitochondrial diseases (specifically Leigh syndrome), that displays a narrow window of relative phenotypical normality, despite its inherent mitochondrial complex I dysfunction and severe phenotype. Preclinical observations related to psychiatric comorbidities that arise in patients with mitochondrial diseases and indeed
-
Discriminative stimulus and reinforcing effects of diclazepam in rodents Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-11-26 Wonjong Lee, Jung Won Lee, Sungsun Kim, Jin Mook Kim, Dong-Hyun Youn, Seong Hye Park, Chan Hyeok Kwon, Sun-Ok Choi
-
Reduction of claudin-5 and aquaporin-4 in the rat hippocampal CA-1 and CA-3 regions of a learned helplessness model of depression Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-11-21 Yuki Hirose, Yasunori Oda, Kouhei Yoshino, Fumiaki Yano, Makoto Kimura, Hiroshi Kimura, Masaomi Iyo, Yukihiko Shirayama
Background Although findings from both animal and clinical research indicate that the blood-brain barrier (BBB) contributes to the pathogenesis of various psychiatric disorders (including depression), the underlying mechanisms are unknown. We investigated the levels of the tight-junction proteins claudin-5 and aquaporin-4 (AQP-4) in astrocytes of learned helplessness (LH) rats (an animal model of depression)
-
Acute and chronic glutamate NMDA antagonist treatment attenuates dopamine D1 antagonist-induced reduction of nicotine self-administration in female rats Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-11-16 Sarabesh Natarajan, Grant Abass, Lucas Kim, Corinne Wells, Amir H. Rezvani, Edward D. Levin
Multiple interacting neural systems are involved in sustaining nicotine reinforcement. We and others have shown that dopamine D1 receptors and glutamate NMDA receptors both play important roles in nicotine reinforcement. Blockade of D1 receptors with the antagonist SCH-23390 (0.02 mg/kg) both acutely and chronically significantly decreased nicotine self-administration in rats. Blockade of NMDA receptors
-
Gestational environmental enrichment prevents chronic social stress induced anxiety- and ethanol-related behaviors in offspring Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-11-16 Amine Bahi
Epidemiological surveys have shown a strong relationship between maternal stress and offspring's mood disorders. Growing evidence suggested that environmental enrichment (EE) improves cognitive function in models of psychiatric and neurological disorders. However, the potential protective effects of gestational EE on social stress-elicited mood disorders in offspring have not been studied. Knowing
-
Sex difference affects fear extinction but not lithium efficacy in rats following fear-conditioning with respect to the hippocampal level of BDNF Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-11-14 Mehrsa Rahimi-Danesh, Mohammad-Ali Samizadeh, Amir-Ehsan Sajadi, Tara Rezvankhah, Salar Vaseghi
In rodents, exposure to electrical shock and creating a strong fear memory using fear-conditioning model can induce PTSD-like behavior. In this study, we induced a fear-conditioning model in rats and investigated freezing (PTSD-like) behavior, 21 days after three shocks exposure (0.6 mA, 3 s, 30 seconds interval) in both male and female rats. Lithium was injected intraperitoneally (100 mg/kg) in three
-
Hydrogen sulfide attenuates depression-like behaviours in Parkinson's disease model rats by improving synaptic plasticity in a hippocampal Warburg effect-dependent manner Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-11-13 Fen Liu, Qing Tian, Hui-Ling Tang, Xiang Cheng, Wei Zou, Ping Zhang
Background Depression is a highly prevalent comorbidity arising in patients with Parkinson's disease (PD). However, depression in patients with PD is poorly treated. Hydrogen sulfide (H2S), a neuromodulator, has the potential to relieve depression. Objective To investigate whether H2S attenuates depression-like behaviours in a rat model of PD and examine the underlying mechanisms. Methods We utilised
-
Nebulized and intraperitoneal ketamine have equivalent antidepressant-like effect in the forced swim and tail suspension tests in mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-11-08 Aida A.C. Brandão, Deborah L.S. Deus, Luiz A.M.S. Duarte-Filho, Pedro M.N. Menezes, Ana B.R. Massaranduba, Fabrício S. Silva, Luciano A.A. Ribeiro
Major depressive disorder (MDD) is a debilitating illness that affects millions of people worldwide. Currently available antidepressants often take weeks to months to reach their full effect, which leads to an increased risk of suicidal behavior in patients with MMD. Intranasally, esketamine has emerged as an alternative to current antidepressants because of its rapid onset and long-lasting effects
-
The low ratio of ghrelin in plasma and cerebrospinal fluid might be beneficial to sleep Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-11-07 Yuanyuan Chen, Hui Li, Tiantian Kong, Ligang Shan, Lei Hao, Fan Wang
Objective Ghrelin is physiologically important for maintaining sleep rhythm. Cigarette smoking has been demonstrated to significantly increase the risk of insufficient sleep by regulating ghrelin at the central and peripheral levels. No research has been published to study the relationship between active smoking and sleep via ghrelin level in cerebrospinal fluid (CSF). Methods A total of 139 Chinese
-
Interactions between lorcaserin and opioids: Ventilation and food-versus-drug choice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-11-10 David R. Maguire
Lorcaserin, a selective serotonin 2C (5-HT2C) receptor agonist, was approved for treating obesity and has been investigated for treating substance use disorders including those involving opioids. Although lorcaserin was withdrawn from the market, interest in the therapeutic potential of drugs acting at 5-HT2C receptors continues, supporting the need to further characterize potential adverse effects
-
Ketamine retards recovery from reward downshift and supports conditioned taste aversion Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-28 Antonio D.R. Agüera, Clara Cándido, Rocío Donaire, Mauricio R. Papini, Carmen Torres
Ketamine is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist with antidepressant, anxiolytic, and memory effects in clinical and preclinical studies. The present studies investigated the behavioral effects of ketamine in animals exposed to a consummatory successive negative contrast (cSNC) task involving unexpected reward downshift, negative emotion (frustration), and aversive memory
-
Sertraline associated with gold nanoparticles reduce cellular toxicity and induce sex-specific responses in behavior and neuroinflammation biomarkers in a mouse model of anxiety Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-23 H.M. Abelaira, A.B. de Moura, M.M. Cardoso, E. de Pieri, J.S. Abel, G.P. Luiz, E.M. Sombrio, L.A. Borghezan, R.S. Anastácio, L.A. Cruz, T.G. de Souza, Corrêa MEAB, I.R. Lima, C. da Costa, A.G. Dal Bó, Silveira PCL, R.A. Machado-de-Ávila
This study aimed to evaluate the effects of sertraline associated with gold nanoparticles (AuNPs) in vitro cell viability and in vivo behavior and inflammatory biomarkers in a mouse model of anxiety. Sertraline associated with AuNPs were synthesized and characterized. For the in vitro study, NIH3T3 and HT-22 cells were treated with different doses of sertraline, AuNPs, and sertraline + AuNPs and their
-
Prophylactic effects of arketamine, but not hallucinogenic psychedelic DOI nor non-hallucinogenic psychedelic analog lisuride, in lipopolysaccharide-treated mice and mice exposed to chronic restrain stress Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-14 Guilin Liu, Li Ma, Youge Qu, Xiayun Wan, Dan Xu, Mingming Zhao, Rumi Murayama, Kenji Hashimoto
Anesthetic ketamine and classical psychedelics that act as 5-hydroxytryptamine-2A receptor (5-HT2AR) agonists demonstrated rapid and sustained antidepressant actions in patients with treatment-resistant depression. The new antidepressant arketamine is reported to cause long-lasting prophylactic effects in lipopolysaccharide (LPS)-treated mice and mice exposed to chronic restrain stress (CRS). However
-
Pre-mating administration of theophylline could prevent the transgenerational effects of maternal morphine dependence on offspring anxiety behavior: The role of dopamine receptors Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-16 Kamran Ghaffari, Parviz Dousti Kataj, Anahita Torkaman-Boutorabi, Nasim Vousooghi
Opioid addiction causes some molecular alterations in the brain reward pathway, such as changes in gene expression that may be transferred to the next generation via epigenetic mechanisms such as histone acetylation. This study aimed to evaluate the effect of theophylline as an HDAC (Histone deacetylases) activator on D1 and D2 dopamine receptor expression in the nucleus accumbens (NAc) and anxiety
-
Sex-dependent and long-lasting effects of adolescent sleep deprivation on social behaviors in adult mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-05 Jiping Xue, Bingyu Li, Boya Huang, Hao Feng, Xinrui Li, Shihao Liang, Fang Yuan, Sheng Wang, Haishui Shi, Juan Shao, Yun Shi
Increasing evidence indicates that sleep deprivation (SD) can exert multiple negative effects on neuronal circuits, resulting in memory impairment, depression, and anxiety, among other consequences. The long-term effects of SD during early life on behavioral phenotypes in adulthood are still poorly understood. In this study, we investigated the long-lasting effects of SD in adolescence on social behaviors
-
Interactions between estradiol and ERK, but not mTOR, signaling is necessary for enhanced cocaine-induced conditioned place preference in female rats Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-05 Saurabh S. Kokane, Brandon D. Butler, Josimar Hernandez Antonio, Ross J. Armant, Adam C. Hoch, Clinton S. Coelho, Blake N. Brady, Houda H. Chamseddine, Linda I. Perrotti
Women rapidly progress from recreational cocaine use to dependence, consume greater quantities of cocaine, experience more positive subjective effects of cocaine and have higher incidences of relapse during abstinence. These effects have been replicated in animal models of cocaine addiction and indicate an enhanced sensitivity and therefore, vulnerability of females to cocaine addiction. Furthermore
-
Involvement of the serotoninergic system in the anxiolytic action mechanism of a liposomal formulation containing nimodipine (NMD-Lipo) Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-05 Hellen Kelen Maria Medeiros Coimbra Viana, George Laylson da Silva Oliveira, Lina Clara Gayoso e Almendra Ibiapina Moreno, Ana Amélia Carvalho de Melo-Cavalcante, Maurício Pires de Moura do Amaral, Daniel Dias Rufino Arcanjo, Hercília Maria Lins Rolim
In the search for anxiolytic drugs with fewer adverse effects, calcium blockers were proposed as a benzodiazepines (BZDs) alternative. In this context, the anxiolytic effect of nimodipine has been demonstrated. However, its low bioavailability and solubility could be improved by using nanostructured drug delivery systems such as liposomes. In this way, liposomal formulation containing nimodipine (NMD-Lipo)
-
Adolescent intermittent alcohol exposure produces strain-specific cross-sensitization to nicotine and other behavioral adaptations in adulthood in C57BL/6J and DBA/2J mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-05 Laurel R. Seemiller, Prescilla Garcia-Trevizo, Carlos Novoa, Lisa R. Goldberg, Samantha Murray, Thomas J. Gould
Adolescent alcohol exposure is associated with lasting behavioral changes in humans and in mice. Prior work from our laboratory and others have demonstrated that C57BL/6J and DBA/2J mice differ in sensitivity to some effects of acute alcohol exposure during adolescence and adulthood. However, it is unknown if these strains differ in cognitive, anxiety-related, and addiction-related long-term consequences
-
Anxiolytic-like action of 3-((4-methoxyphenyl)selanyl)-2-phenylbenzofuran (SeBZF3) in mice: A possible contribution of the serotonergic system Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-02 Larissa Sander Magalhães, Dianer Nornberg Strelow, Mariana Parron Paim, Taís da Silva Teixeira Rech, Letícia Devantier Krüger, Antonio Luiz Braga, José Sebastião Santos Neto, César Augusto Brüning, Cristiani Folharini Bortolatto
-
Melanin-concentrating hormone receptor antagonism differentially attenuates nicotine experience-dependent locomotor behavior in female and male rats Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-02 Isabel R.K. Kuebler, Youxi Liu, Bárbara S. Bueno Álvarez, Noah M. Huber, Joshua A. Jolton, Raaga Dasari, Ken T. Wakabayashi
Nicotine is a significant public health concern because it is the primary pharmacological agent in tobacco use disorder. One neural system that has been implicated in the symptoms of several substance use disorders is the melanin-concentrating hormone (MCH) system. MCH regulates various motivated behaviors depending on sex, yet little is known of how this interaction affects experience with drugs of
-
Multistrain probiotic rescinds quinpirole-induced obsessive-compulsive disorder phenotypes by reshaping of microbiota gut-brain axis in rats Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-05 Shubham Ghuge, Ziaur Rahman, Nagesh A. Bhale, Amol G. Dikundwar, Manoj P. Dandekar
Obsessive-compulsive disorder (OCD) is a disabling mental condition that poses recurring bothersome intrusive thoughts, obsessions, and compulsions. Considering the positive impact of probiotics on neuropsychiatric disorders, herein, we investigated the effect of multistrain probiotic (Bifidobacterium lactis UBBLa-70, Bacillus coagulans Unique IS-2, Lactobacillus rhamnosus UBLR-58, Lactobacillus plantarum
-
Influence of the dose of ketamine used on schizophrenia-like symptoms in mice: A correlation study with TH, GAD67, and PPAR-γ Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-05 Talita Rodrigues, Getulio Nicola Bressan, Bárbara Nunes Krum, Félix Alexandre Antunes Soares, Roselei Fachinetto
Schizophrenia is a chronic, debilitating mental illness that has not yet been completely understood. In this study, we aimed to investigate the effects of different doses of ketamine, a non-competitive NMDA receptor antagonist, on the positive- and negative-like symptoms of schizophrenia. We also explored whether these effects are related to changes in the immunoreactivity of GAD67, TH, and PPAR-γ
-
The role of social variables in drug use and addiction Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-10-05 Mark Smith, Matthew G. Kirkpatrick, Cassandra D. Gipson
Abstract not available
-
Activation of mediodorsal thalamic dopamine receptors inhibited nicotine-induced anxiety in rats: A possible role of corticolimbic NMDA neurotransmission and BDNF expression Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-09-29 Seyedeh Leila Mousavi, Ameneh Rezayof, Sakineh Alijanpour, Ladan Delphi, Oveis Hosseinzadeh Sahafi
-
Fluoxetine combined with swimming exercise synergistically reduces lipopolysaccharide-induced depressive-like behavior by normalizing the HPA axis and brain inflammation in mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-09-21 Hassan Amouzad Mahdirejei, Maghsoud Peeri, Mohammad Ali Azarbayjani, Forouzan Fattahi Masrour
Major depression disorder is a debilitating psychiatric disease affecting millions of people worldwide. This disorder is the leading cause of morbidity and mortality in high-income countries. Selective serotonin reuptake inhibitors such as fluoxetine are first-line drugs for treating depression-related disorders, but not all patients respond well to these antidepressants. This study aimed to evaluate
-
FABP5 is important for cognitive function and is an important regulator of the physiological effects and pharmacokinetics of acute Δ9 tetrahydrocannabinol inhalation in mice Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-09-15 Samantha L. Penman, Nicole M. Roeder, Erin C. Berthold, Alexandria S. Senetra, Matthew Marion, Brittany J. Richardson, Olivia White, Nathan L. Fearby, Christopher R. McCurdy, John Hamilton, Abhisheak Sharma, Panayotis K. Thanos
Fatty acid binding protein 5 (FABP5) interacts with the endocannabinoid system in the brain via intracellular transport of anandamide, as well as Δ9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis. Previous work has established the behavioral effects of genetic deletion of FABP5, but not in the presence of THC. The present study sought to further elucidate the role of FABP5
-
Role of mGlu receptors in psychiatric disorders – Recent advances Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-09-19 Andrzej Pilc, Shigeyuki Chaki
Abstract not available
-
Modulation of cue value and the augmentation of heroin seeking in chronically food-restricted male rats under withdrawal Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-09-14 Firas Sedki, Tracey M. D'Cunha, Damaris Rizzo, Leon Mayers, Jennifer Cohen, Suzanne Trieu Chao, Uri Shalev
Food restriction augments drug seeking in abstinent rats. The underlying motivational mechanisms, however, remain unclear. We hypothesized that caloric restriction enhances the incentive value attributed to drug-associated cues and, in turn, augments drug seeking. Male rats were trained to lever-press for heroin, and then moved to the animal colony for a forced-abstinence period. Rats were maintained
-
Activation of mGlu2/3 receptors in the striatum alleviates L-DOPA-induced dyskinesia and inhibits abnormal postsynaptic molecular expression Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-09-14 Yang Tan, Chi Cheng, Cong Zheng, Weiqi Zeng, Xiaoman Yang, Yu Xu, Zhaoyuan Zhang, Zhuoran Ma, Yan Xu, Xuebing Cao
Group II metabotropic glutamate receptors (mGlu2/3 receptors) have been regarded as promising candidates for the treatment of L-DOPA-induced dyskinesia (LID); however, confirmation is still lacking. As the hub of the basal ganglia circuit, the striatum plays a critical role in action control. Supersensitive responsiveness of glutamatergic corticostriatal input may be the key mechanism for the development
-
Sex, but not juvenile stress, affects reversal learning and DRL performance following cocaine administration Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-09-16 Tracie A. Paine, Caroline Pierotti, Evan S. Swanson, Zoë Martin del Campo, Sydney Kulkarni, Jeffrey Zhang
Introduction Early adversity, impulsivity and sex all contribute to the risk of developing substance use disorder. Using rats, we examined how juvenile stress interacts with sex and cocaine to affect performance on a serial reversal task and a differential reinforcement of low rates 10 s (DRL10) task. The expression of dopamine-related proteins in several brain areas was also assessed. Methods From
-
The endowment effect and temporal discounting of drug and non-drug commodities Pharmacol. Biochem. Behav. (IF 3.6) Pub Date : 2023-09-16 Sean D. Regnier, Mark J. Rzeszutek, Justin C. Strickland, Thomas P. Shellenberg, William W. Stoops
Objectives Despite a rich history of behavioral economic research on substance use there remains a need for further exploration of behavioral mechanisms that may underlie the etiology or persistence of substance use disorder. The purpose of this study was to measure the association between delay discounting and the endowment effect in people who smoke cigarettes, use cocaine, and controls, using online