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Pet collars containing tetrachlorvinphos (TCVP): evaluation of the results of torsion and on-animal release studies and implications for post-application consumer exposure and risk analysis J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-03-11 Jeffrey H. Driver, Curt Lunchick, Joseph Conti, Preston Davis, Michael Tyler, Kimball Woelfel, William Russel Everett, John Ross
Tetrachlorvinphos (TCVP) is the pesticidal active ingredient found in some flea and tick collars for dogs and cats. Recent studies sponsored by The Hartz Mountain Corporation, confirm the safety of...
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Expression of Concern: Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-03-11
Published in Journal of Toxicology and Environmental Health, Part A: Current Issues (Vol. 87, No. 9, 2024)
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Oral subacute polypropylene microplastics administration effect on potential immunotoxicity in ICR mice J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-03-05 Sarina Kusma, Anju Maharjan, Manju Acharya, DaEun Lee, SoYeon Kim, ChaeWon Hwang, KilSoo Kim, HyoungAh Kim, Yong Heo, ChangYul Kim
Exposure to microplastics may be associated with damage of immune system. Polypropylene microplastics (PP-MPs) with a wide range of beneficial applications have not been extensively studied with re...
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Toxicity evaluation of novel imidacloprid nanoribbons, using somatic mutation and fitness indexes in Drosophila melanogaster J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-02-22 Luz M. Vidal, Emilio Pimentel, Luis Escobar-Alarcón, Martha P. Cruces, Elizabeth Jiménez, Hugo Suárez, Yosary Leyva
Nanoribbons of imidacloprid, a systemic and chloronicotinyl insecticide, were successfully synthesized by laser-induced fragmentation/exfoliation of imidacloprid powders suspended in water, with wi...
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Effects of sodium dodecylbenzene sulfonate (SDBS) on zebrafish (Danio rerio) gills and blood J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-02-06 Eduardo Libanio Reis Santos, Odaiza Silva, Bruna Jéssyca Nascimento Araújo, Milena de Lima Rodrigues, Jeffesson de Oliveira-Lima, Maria Izabel Camargo-Mathias
Sodium dodecylbenzene sulfonate (SDBS) is an important surfactant used as a cleaning agent and industrial additive to remove unwanted chemicals which have been detected in the aquatic environment. ...
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Piperlongumine inhibits antioxidant enzymes, increases ROS levels, induces DNA damage and G2/M cell cycle arrest in breast cell lines J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-02-05 Adrivanio Baranoski, Simone Cristine Semprebon, Bruna Isabela Biazi, Thalita Alves Zanetti, Amanda Cristina Corveloni, Lilian Areal Marques, Sandra R. Lepri, Giuliana Castello Coatti, Mário Sérgio Mantovani
Piperlongumine (PLN) is a biologically active alkaloid/amide derived from Piper longum, with known promising anticancer activity. The aim of this study was to compare the antiproliferative activity...
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Antimutagenic and antitumor activities of a water-soluble fraction of soursop (syn Graviola, Annona muricata L.) fruit pulp J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-02-05 Raissa Miranda Scharf, Carine Oliveira Gonçalves, Andreia da Silva Fernandes, José Luiz Mazzei, Elisa Raquel Anastácio Ferraz, Carlos Fernando Araujo Lima, Israel Felzenszwalb
Soursop (Annona muricata) is a tropical tree whose decoction derived from bark, root, seed, or leaf has been used for medicinal uses. In addition, the fruit itself is considered a food, and the jui...
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Pulmonary evaluation of whole-body inhalation exposure of polycarbonate (PC) filament 3D printer emissions in rats J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-02-06 Mariana T. Farcas, Walter McKinney, W. Kyle Mandler, Alycia K. Knepp, Lori Battelli, Sherri A Friend, Aleksandr B. Stefaniak, Samantha Service, Michael Kashon, Ryan F. LeBouf, Treye A. Thomas, Joanna Matheson, Yong Qian
During fused filament fabrication (FFF) 3D printing with polycarbonate (PC) filament, a release of ultrafine particles (UFPs) and volatile organic compounds (VOCs) occurs. This study aimed to deter...
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How do different concentrations of aluminum and zinc affect the survival, body size, morphology and immune system of Physalaemus cuvieri (Fitzinger, 1826) tadpole? J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-02-06 Vagner José de Albuquerque, Alexandre Folador, Caroline Müller, Aline Pompermaier, Marília Hartmann, Paulo Afonso Hartmann
The assessment of amphibian responses as bioindicators of exposure to chemical pollutants is an important tool for conservation of native species. This study aimed to investigate the effects of chr...
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Ethanolic extract from leaves of tithonia diversifolia induces apoptosis in HCT-116 cells through oxidative stress J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-01-29 Maria Fernanda Madrid Mendoza, Jessica Almeida Mota, Fatima de Cassia Evangelista de Oliveira, Bruno Coêlho Cavalcanti, João Fabio Turco, Yohandra Reyes Torres, Paulo Michel Pinheiro Ferreira, Francisco W. A. Barros-Nepomuceno, Danilo Damasceno Rocha, Claudia Pessoa, Manoel Odorico de Moraes Filho
Tithonia diversifolia is a perennial bushy plant found in South America with significant ethnopharmacological importance as an antimalarial, antidiabetic, antibacterial, and anticancer agent. The a...
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Tellimagrandin-I and camptothin a exhibit chemopreventive effects in Salmonella enterica serovar Typhimurium strains and human lymphocytes J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-01-08 Amanda Silva Fernandes, Abel Vieira de Melo Bisneto, Luana Santos Silva, Elisa Flávia Luiz Cardoso Bailão, Clever Gomes Cardoso, Cristiene Costa Carneiro, Suzana da Costa Santos, Lee Chen-Chen
Tellimagrandin-I (TL) and camptothin A (CA) are ellagitannins widely found in diverse plant species. Numerous studies demonstrated their significant biological activities, which include antitumor, ...
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Evaluation of the anti-androgenic and cytotoxic effects of benzophenone-3 in male Sprague-Dawley rats J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-01-10 Chi Rim Sung, Byeong Jun Kim, Chan Ju Park, In Ah Oh, Yu Jin Lee, Yeo Rim Park, Seung Jun Kwack
Benzophenone-3 (BP-3, 2-hydroxy-4-methoxybenzophenone, oxybenzone) is one of the most widely used types of benzophenone organic sunscreen. However, this compound is a potentially harmful toxicant. ...
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Marketable 1,3-dimethylamylamine and caffeine-based thermogenic supplements: Regulatory genotoxicity assessment through in vitro and in silico approaches J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-01-10 Eduardo Kennedy Carrão Dantas, Caroline Lopes Simões Ferreira, Alana da Cunha Goldstein, Andreia da Silva Fernandes, Elisa Raquel Anastacio Ferraz, Israel Felzenszwalb, Carlos Fernando Araújo-Lima
The consumption of dietary supplements to enhance physical performance has increased significantly in the last century, especially thermogenic pre-workout supplements. Nevertheless, this industry h...
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Effects of docetaxel on metastatic prostate (DU-145) carcinoma cells cultured as 2D monolayers and 3D multicellular tumor spheroids J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2024-01-10 Andressa Yuri Fujiike, Larissa Cristina Bastos de Oliveira, Diego Luis Ribeiro, Érica Romão Pereira, Nádia Calvo Martins Okuyama, Anna Gabriele Prado dos Santos, Ilce Mara de Syllos Cólus, Juliana Mara Serpeloni
Docetaxel (DTX) is one of the chemotherapeutic drugs indicated as a first-line treatment against metastatic prostate cancer (mPCa). This study aimed to compare the impact of DTX on mPCa (DU-145) tu...
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Assessing the disparity: comparative toxicity of Copper in zebrafish larvae exposes alarming consequences of permissible concentrations in Brazil J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-12-26 Maria Vitória Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thaís Posser, Jeferson Luis Franco
Copper (Cu) is a naturally occurring metal with essential micronutrient properties. However, this metal might also pose increased adverse environmental and health risks due to industrial and agricu...
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Exploring the multifaceted effects of Ammi visnaga: subchronic toxicity, antioxidant capacity, immunomodulatory, and anti-inflammatory activities J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-12-26 Martin Ndayambaje, Hicham Wahnou, Marieme Sow, Oumaima Chgari, Thierry Habyarimana, Mehdi Karkouri, Youness Limami, Abdallah Naya, Mounia Oudghiri
Ammi visnaga (A. visnaga) is an annual herb that has been used in traditional medicine to treat various ailments attributed to the presence of its bioactive compounds. The purpose of this study was...
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The importance of recognizing Buffer Zones to lands being developed, restored, or remediated: on planning for protection of ecological resources J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-12-26 Joanna Burger, Michael Gochfeld, Kevin G. Brown, Kelly Ng, Monica Cortes, David Kosson
Environmental management relies on many types of information before making decisions regarding remediation, restoration, or other land use decisions, including ecological data, such as risks to spe...
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Modulatory effects of dietary saturated fatty acids on platelet mitochondrial function following short-term exposure to ambient Particulate Matter (PM2.5) J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-12-18 Wan Shen, Hao Chen, Chiahao Shih, James Samet, Haiyan Tong
Exposure to ambient fine particulate matter (PM2.5) was found to produce vascular injury, possibly by activating platelets within days after exposure. The aim of this study was to investigate the m...
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Phytochemical analysis of carotenoid profile in Mentha piperita and Artemisia vulgaris: cytotoxicity in tumoral cells and evaluation of plasmid DNA cleavage J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-12-11 Altevir Rossato Viana, James Eduardo Lago Londero, Pricila Nass Pinheiro, Patricia Acosta, Larissa Duailibe Silva, Eduardo Jacob-Lopes, Aline Ferreira Ourique, Leila Queiroz Zepka, Cristiano Rodrigo Bohn Rhoden, André Passaglia Schuch, Camila Franco
Several medicinal plants have been administered to cancer patients attributed to their anticarcinogenic and chemoprotective properties, in addition to lower toxicity compared to traditional therapi...
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Cytogenotoxicity evaluation of heavy metals detected in extracts and infusion of Baccharis trimera, potential bioaccumulator plant J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-11-30 Regildo Márcio Gonçalves da Silva, Vanessa Marques de Oliveira Moraes, Filipe Oliveira Granero, Célia Cristina Malaguti Figueiredo, Valter Henrique Marinho dos Santos, Levi Pompermayer Machado, Luciana Pereira Silva
Heavy metals (HMs) are natural components of the Earth’s crust that might originate from natural and anthropogenic sources. In excess quantities, the presence of these metals is harmful for both en...
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In vitro evaluation of cytotoxic potential of essential oil extracted from leaves of Croton heliotropiifolius Kunth in human tumor cells J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-11-30 Bruno Coêlho Cavalcanti, Islay Lima Magalhães, Danilo Damasceno Rocha, Francisco Stefânio Barreto, João Batista de Andrade Neto, Hemerson Iury Ferreira Magalhães, Cláudio Costa dos Santos, Manoel Odorico de Moraes
Croton heliotropiifolius Kunth, popularly known as “velame,” is a shrub that resides in northeastern Brazil. The essential oil of C. heliotropiifolius contains high concentrations of volatile compo...
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Cylindrospermopsin exposure promotes redox unbalance and tissue damage in the liver of Poecilia reticulata, a neotropical fish species J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-11-30 Simone Maria Teixeira de Sabóia-Morais, João Marcos de Lima Faria, Jéssica Custódio da Silva Rabelo, Alex Lucas Hanusch, Lorena Alves Mesquita, Raquel de Andrade Silva, Jerusa Maria de Oliveira, Lázaro Wender Oliveira de Jesus
There is a growing concern regarding the adverse risks exposure to cylindrospermopsin (CYN) might exert on animals and humans. However, data regarding the toxicity of this cyanotoxin to neotropical...
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Graphene oxide decreases the effects of salt stress on Persian clover seed germination J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-11-27 Raquel Stefanello, Wagner Jesus da Silva Garcia, Altevir Rossato Viana, Theodoro da Rosa Salles, Cristiano Rodrigo Bohn Rhoden
Among biotic and abiotic stresses, the most restrictive for plant distribution is salt stress, where different concentrations might exert harmful effects on seed germination. Recently, nanomaterial...
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Cytotoxic, antioxidant, and antiglycation activities, and tyrosinase inhibition using silver nanoparticles synthesized by leaf extract of Solanum aculeatissimum Jacq J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-11-27 Regildo Márcio Gonçalves da Silva, Isabelly Do Nascimento Pereira, Laura Camargo Zibordi, Pedro Augusto Pereira Rosatto, Filipe Oliveira Granero, Célia Cristina Malaguti Figueiredo, Carlos José Leopoldo Constantino, Cibely da Silva Martin, Aldo Eloizo Job, Nilson Nicolau-Junior, Luciana Pereira Silva
The present study aimed to determine the biological properties of an extract of Solanum aculeatissimum aqueous extract (SaCE) alone as well as silver nanoparticles (AgNPs) generated by green synthe...
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Correction J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-11-20
Published in Journal of Toxicology and Environmental Health, Part A: Current Issues (Ahead of Print, 2023)
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Limited impact of weathered residues from the Deepwater Horizon oil spill on the gut-microbiome and foraging behavior of sheepshead minnows (Cyprinodon variegatus) J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-11-23 Maggie A. Wigren, Timothy A. Johnson, Robert J. Griffitt, Anthony G. Hay, Jonathan A. Knott, Maria S. Sepúlveda
The Deepwater Horizon disaster of April 2010 was the largest oil spill in U.S. history and exerted catastrophic effects on several ecologically important fish species in the Gulf of Mexico (GoM). W...
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Sublethal perfluorooctanoic acid and perfluorooctanesulfonic acid delay C. elegans larval development and population growth but do not alter egg hatching J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-11-23 Celine Breton, Kaitlyn Kessel, Ariel Robinson, Kainat Altaf, Eric S. Luth
Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) are polyfluoroalkyl substances (PFAS) used as surface coatings in manufacturing. Exposure to PFAS was shown to be correlated wi...
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Study of the DNA damage and cell death in human peripheral blood mononuclear and HepG2/C3A cells exposed to the synthetic 3-(3-hydroxyphenyl)-7-hydroxycoumarin J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-11-23 André Rogerio Pereira, Ashley Silva Campos, Maria João Matos, Edson Luis Maistro
Hydroxycoumarins are an important source of biologically active compounds. Previous studies have shown that the number and position of the hydroxyl substituents in the scaffold play an important ro...
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Metal levels in waste pickers in Brasilia, Brazil: hair and nail as exposure matrices J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-11-09 Michelly Rodrigues Gonçalves, Vanessa Resende Nogueira Cruvinel, Steven Verpaele, Morteza Bashash, Carla Pintas Marques, Mariana Ragassi Urbano, Monica Maria Bastos Paoliello, Michael Aschner, Vivian da Silva Santos
The aim of this cross-sectional study was to compare workplace conditions and metal exposures in 431 waste pickers who worked nearby at the Estrutural Dump in Brasilia utilizing hair (n = 310) and ...
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Effects of mine tailing exposure on the development of early life stages of the marine copepod Calanus finmarchicus J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-10-30 Julia Farkas, Linn H. Svendheim, Ida B. Øverjordet, Emlyn J. Davies, Dag Altin, Trond Nordtug, Pål A. Olsvik, Tjalling Jager, Bjørn Henrik Hansen
The demand for mineral resources is increasing mining activities worldwide. In Norway, marine tailing disposal (MTD) is practiced, introducing mineral particles into fjord ecosystems. We investigat...
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Do oil droplets and chemical dispersants contribute to uptake of oil compounds and toxicity of crude oil dispersions in cold-water copepods? J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-10-23 Bjørn Henrik Hansen, Dag Altin, Trond Nordtug
Accidental crude oil spills to the marine environment cause dispersion of oil into the water column through the actions of breaking waves, a process that can be facilitated using chemical dispersan...
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Effects of curcumin to counteract levodopa-induced toxicity in zebrafish J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-10-05 Paola Briñez-Gallego, Dennis Guilherme da Costa Silva, Ana Paula Horn, Mariana Appel Hort
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor dysfunction due to the death of dopaminergic neurons in the substantia nigra pars compacta. Currently, treatment of P...
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Effects of long-term exposure to ambient fine particulate air pollution on all-cause mortality in Taiwan J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-10-05 Shang-Shyue Tsai, Chun-Yuh Yang
According to the US Environmental Protection Agency’s Integrated Science Assessment (ISA), there is a causal relationship between fine particulate matter (PM2.5) exposure and increased mortality ra...
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Epidemiological profile, temporal analysis, and future projections of suicide cases in rural cities in the extreme south of Brazil J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-10-05 Paula Santos da Silva Araújo, Tatiane Britto da Silveira, Fernando Rafael de Moura, Merlyn dos Santos Maidana, Guaraciaba Ribeiro Duarte de Sousa, Samuel de Carvalho Dumith, Flavio Manoel Rodrigues da Silva Júnior
The present study aimed to verify the time series (2000–2017) of death rates by suicide and its associated factors in 4 municipalities in the extreme south of Brazil. Data were obtained through the...
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Chemopreventive effect and induction of DNA repair by oenothein B ellagitannin isolated from leaves of Eugenia uniflora in Swiss Webster treated mice J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-10-05 Cinthia Aparecida Silva, Jefferson Hollanda Véras, Joyce Aves Ventura, Abel Vieira de Melo Bisneto, Matheus Gabriel de Oliveira, Elisa Flávia Luiz Cardoso Bailão, Carolina Ribeiro e Silva, Clever Gomes Cardoso, Suzana da Costa Santos, Lee Chen-Chen
Oenothein B (OeB) is a dimeric ellagitannin with potent antioxidative, antitumor, immunomodulatory, and anti-inflammatory properties. Despite the promising activities of OeB, studies examining the ...
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Cytotoxic and oxidative changes in individuals occupationally exposed to recyclable municipal solid waste J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-09-10 Camila Pileco Cappelleti, Karen Taiane Santos Silva, Kelly Rodrigues-Conrad, Kendra Caroline Grams, Isadora Kottwitz da Silva, Ana Paula Frielink, Suelen da Rocha Abdallah, Christiane de Fátima Colet, Josiane Woutheres Bortolotto, Gabriela Bonfanti-Azzolin, Mariana Migliorini Parisi
ABSTRACT aste collectors are exposed to a wide variety of bacteria, endotoxins, fungi, allergens, particulate matter, irritating inhalants, and vehicle exhaust, making them more prone to development of chronic diseases. Although several studies described the impact of occupational exposure on the overall health of waste collectors, few investigations were conducted regarding cellular and molecular
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Short-term and repeated exposure to particulate matter sizes from Imperial Valley, California to induce inflammation and asthmatic-like symptoms in mice J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-09-12 Savannah M. D’Evelyn, Keith J. Bein, Emilia A. Laing, Tran Nyguen, Ching-Wen Wu, Qi Zhang, Kent E. Pinkerton
ABSTRACT Imperial Valley, California has become increasingly hot, dry, and polluted over the past decade. Particulate matter (PM) levels are amongst the highest in this State, associated with significantly higher asthma prevalence among children in the region compared to national and state averages. The present study was performed to test the hypothesis that Imperial Valley PM by size and chemical
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Phytochemical characterization and toxicological activity attributed to the acetonic extract of South American Vassobia breviflora J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-09-04 Altevir Rossato Viana, Isadora Nicola, Camila Franco, Patrícia Acosta Caetano, Eduardo Jacob-Lopes, Leila Queiroz Zepka, Daniel Santos, Erico Marlon Moraes Flores, Bruno Stefanello Vizzotto, Katianne Wolf, Aline Ferreira Ourique, Sergio Roberto Mortari, Cristiano Rodrigo Bohn Rhoden, Luciana Maria Fontanari Krause
ABSTRACT The particular plant species found in southern Brazil, Vassobia breviflora (Solanaceae) has only a few apparent studies examining its biological effect. Thus, the aim of the present study was to determine the activity of the acetone extract fraction derived from V. breviflora. Four compounds were identified by ESI-qTOF-MS: eucalrobusone R, aplanoic acid B, pheophorbide A, and pheophytin A
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Phytochemical characterization, isolation, antioxidant and cytogenotoxic activity of leaves of Heliotropium elongatum (Lehm) I.M. Johnst J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-09-08 Poliana Paula Sales, Maria Das Dores Alves de Oliveira, Janine Midori Figueiredo Watanabe, Anna Paulla da Silva Barbosa, Brenda Caylla Alves da Mata, Maria de Jesus e Silva Viana, Paula Catarina Dalia Rego Medeiros, Derick Carvalho Souza, Jurandy Do Nascimento Silva, Nerilson Marques Lima, Joaquim Soares da Costa Júnior, Francielle Alline Martins, Francisco Artur e Silva Filho, Pedro Marcos de Almeida
ABSTRACT Heliotropium elongatum is used to treat inflammation, cough, and flu. This study aimed to characterize the phytochemical profile and determine the total phenolic content (TPC), antioxidant and cytogenotoxic activity of the ethanolic extract (EE), and fractions of H. elongatum leaves. In the phytochemical profile analysis, organic acids, reducing sugars, flavonoids, saponins, anthraquinones
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Disruption of caspase-independent cell proliferation pathway on spheroids (HeLa cells) treated with curcumin J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-09-06 Liana Martins de Oliveira, Luan Vitor Alves de Lima, Matheus Felipe da Silva, Ingrid Felicidade, Sandra Regina Lepri, Mário Sérgio Mantovani
ABSTRACT Curcumin is an antiproliferative phytochemical extracted from Curcuma longa L and which has been studied in preclinical drug screening using cell monolayers and animal models. However, several limitations of these culture systems may be overcome by performing screening with three-dimensional (3-D) cell culture. The aim of this study was to investigate the effects of curcumin on cytotoxicity
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Antioxidant and photoprotective role of latex C-serum from Hevea brasiliensis during 15-week UVB irradiation in male hairless SKH-1 mice J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-09-06 Leandra E. Kerche, Iriana M. Carrara, Poliana C. Marinello, Dalita G.S.M. Cavalcante, Caroline S. Danna, Rubens Cecchini, Alessandra L. Cecchini, Aldo E. Job
ABSTRACT It is known that UVB radiation induces several adverse skin alterations starting from simple photoaging to skin cancer. In addition, it was demonstrated that reactive oxygen species (ROS) were found to be related to cancer development and progression. The aim of study was to examine whether male hairless (SKH-1) mice (Mus musculus) that were subchronically exposed to UVB radiation presented
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Investigation of the combined cytotoxicity induced by sodium butyrate and a flavonoid quercetin treatment on MCF-7 breast cancer cells J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-09-05 Zeynep Betts, Asuman Deveci Ozkan, Burcu Yuksel, Janiah Alimudin, Duygu Aydin, Ozlem Aksoy, Sevinc Yanar
ABSTRACT Quercetin (QUE) belonging to the flavonoid class is a common phytochemical present in the daily diet of some individuals. Quercetin is an important source of free radical scavengers. This property makes this flavonoid a reliable antioxidant with the following properties: anti-inflammatory, anti-diabetic, antimicrobial and anti-carcinogenic. Sodium butyrate (NaBu) acts as a histone deacetylase
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Luteolin photo-protects zebrafish from environmental stressor ultraviolet radiation (UVB) J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-08-23 Gokul Sudhakaran, Madesh Selvam, A.R. Sreekutty, Abhirami Chandran, Bader O. Almutairi, Selvaraj Arokiyaraj, Pachaiappan Raman, Ajay Guru, Jesu Arockiaraj
ABSTRACT Ultraviolet B wavelength ray radiation (UVB) is an environmental stressor with detrimental effects to the aquatic and human systems but also enhances adverse effects when combined with several other environmental factors such as temperature and pollution. UV rays induce cellular oxidative damage and impair motility. This study aimed to examine the photo-protective activity of flavonoid luteolin
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Spring water quality monitoring using multiple bioindicators from multiple collection sites J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-08-20 Igor Romeiro dos Santos, Isabela Náthaly Machado da Silva, Carlos Filipe Camilo-Cotrim, Luciane Madureira de Almeida, Leonardo Luiz Borges, Elisa Flávia Luiz Cardoso Bailão
ABSTRACT The aim of this study was to examine the water quality of the Extrema River spring in a Brazilian Cerrado area. Three collection sites (P1 − P3) were sampled in the dry and rainy seasons, which are close to industries from different sectors. In the physicochemical analysis, a decrease in dissolved oxygen levels (<5 mg/L) and pH (< 6) at P3 was detected. An increase in heterotrophic bacteria
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Toxicological and chemoprevention studies of Brazilian brown propolis from Araucaria sp J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-08-17 Tábata Rodrigues Esperandim, Arthur Barcelos Ribeiro, Iara Silva Squarisi, Letícia Teixeira Marcos de Souza, Thiago Olimpio de Souza, Nathália Oliveira Acésio, Mário Ferreira Conceição Santos, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Denise Crispim Tavares
ABSTRACT Brazilian brown propolis (BBP) is a natural product derived predominantly from the south region of Brazil, where Araucaria forests are dominant. Despite its potential as a source of bioactive compounds with leishmanicidal, anti-inflammatory, nociceptive, and antimicrobial properties, BBP has not been comprehensively studied compared to green propolis. Therefore, this study aimed to determine
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Evaluation of 28-day repeated doses oral toxicity of essential oil from Psidium glaziovianum Kiaersk leaves on various biological parameters in Swiss mice J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-08-11 Wêndeo Kennedy Costa, Matheus Ferreira Do Nascimento, Valquíria Bruna Guimarães Silva, Bruno Vinicius Souza da Silva, Thiago Henrique Napoleão, Maria Tereza dos Santos Correia, Márcia Vanusa da Silva, Alisson Macário de Oliveira
ABSTRACT Only a small number of the many medicinally important species in the genus Psidium L. have had their safety assessed. Psidium glaziovianum, a plant native to Brazil, is reported to exert antinociceptive and anti-inflammatory effects; however, there are no apparent reports of long-term safety following administering of repeated doses. The aim of this study was to examine the effects of 28-day
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Metabarcoding approach to identify bacterial community profiling related to nosocomial infection and bacterial trafficking-routes in hospital environments J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-08-11 Bárbara Gimenes de Castro, Bruno Mari Fredi, Rafael dos Santos Bezerra, Queren Apuque Alcantara, Carlos Eduardo Milani Neme, Daniele Enriquetto Mascarelli, Aline Seiko Carvalho Tahyra, Douglas dos-Santos, Camilla Rizzo Nappi, Fernanda Santos de Oliveira, Flavia Pereira Freire, Giulia Ballestero, Julia Beatriz Menuci Lima, Juliana de Andrade Bolsoni, Juliana Lourenço Gebenlian, Naira Lopes Bibo, Nathália
ABSTRACT Nosocomial infections (NIs) appear in patients under medical care in the hospital. The surveillance of the bacterial communities employing high-resolution 16S rRNA profiling, known as metabarcoding, represents a reliable method to establish factors that may influence the composition of the bacterial population during NIs. The present study aimed to utilize high-resolution 16S rRNA profiling
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Antiinflammatory effect of the ethanolic extract of Korean native herb Potentilla rugulosa Nakai in Bisphenol-a-stimulated A549 cells J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-08-01 Yong Geon Choi, Won Seok Choi, Jin Yong Song, Yubin Lee, Su Hyun Lee, Jong Seok Lee, Sarah Lee, Se Rin Choi, Choong Hwan Lee, Ji-Yun Lee
ABSTRACT Potentilla rugulosa Nakai (P. rugulosa) is a perennial herb in the Rosaceae family and found in the Korean mountains. Previously, our findings demonstrated that P. rugulosa contains numerous polyphenols and flavonoids exhibiting important antioxidant and anti-obesity bioactivities. Bisphenol A (BPA) is a xenoestrogen that was shown to produce pulmonary inflammation in humans. However, the
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A bioanalytical approach for assessing the effects of soil extracts from solid waste dumpsite in Calabar (Nigeria) on lipid and estrogenic signaling of fish Poeciliopsis lucida hepatocellular carcinoma-1 cells in vitro and in vivo African catfish (Clarias gariepinus) J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-07-28 Oju Richard Ibor, Essa Ahsan Khan, Augustine Arkuwe
ABSTRACT In applying bioanalytical approaches, the aim of this study was to determine the toxicity of contaminants derived from a solid waste dumpsite in Calabar (Nigeria), by investigating the alterations of lipid and estrogen signaling pathways in Poeciliopsis lucida hepatocellular carcinoma-1 (PLHC-1) cells and compared to in vivo African catfish (Clarias gariepinus), using polar, nonpolar and elutriate
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Health benefits of reducing ambient levels of fine particulate matter: a mortality impact assessment in Taiwan J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-07-24 Shang-Shyue Tsai, Chun-Yuh Yang
ABSTRACT While numerous studies have found a relationship between long-term exposure to airborne fine particulate matter (PM2.5) and higher risk of death, few investigations examined the contribution that a reduction of exposure to ambient PM2.5 levels might exert on mortality rates. This study aimed to collect data on changes in annual average ambient levels of PM2.5 from 2006 to 2020 and consequent
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Compositional variations in metal nanoparticle components of welding fumes impact lung epithelial cell toxicity J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-07-24 Li Xia, Jae Hong Park, Katelyn Biggs, Chang Geun Lee, Li Liao, Jonathan H. Shannahan
ABSTRACT Welding fumes contain harmful metals and gas by-products associated with development of lung dysfunction, asthma, bronchitis, and lung cancer. Two prominent welding fume particulate metal components are nanosized iron (Fe) and manganese (Mn) which might induce oxidative stress and inflammation resulting in pulmonary injury. Welding fume toxicity may be dependent upon metal nanoparticle (NP)
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Toxicological profile of the Hymenaea courbaril stem bark hydroalcoholic extract using in vitro bioassays and an alternative in vivo Caenorhabditis elegans model J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-07-24 Larissa Aline Carneiro Lobo, Peterson Alves Santos, Jayne Torres de Sousa, Jaqueline Nascimento Picada, Sara Elis Bianchi, Valquiria Linck Bassani, Francisco Carlos da Silva, Eduardo Miranda Ethur, Márcia Inês Goettert, Patrícia Pereira
ABSTRACT Hymenaea genus has been used in folk medicine in Brazil, but few studies investigated its toxicity profile. Thus, the aim of this study was to determine toxicological parameters of Hymenaea courbaril stem bark hydroalcoholic extract by utilizing three cell lines including murine macrophages (RAW 264.7), mouse fibroblast cells (L929) and human lung fibroblast (MRC-5), as well as Salmonella/microsome
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Genotoxic action of bifenthrin nanoparticles and its effect on the development, productivity, and behavior of Drosophila melanogaster J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-07-21 Martha P. Cruces, Emilio Pimentel, Luz M. Vidal, Elizabeth Jiménez, Hugo Suárez, Enrique Camps, Enrique Campos-González
ABSTRACT Rapid development of nanotechnology, particularly nanoparticles of pesticides, has facilitated the transformation of traditional agriculture. However, testing their effectiveness is essential for avoiding any environmental or adverse human health risk attributed to nanoparticle-based formulations, especially insecticides. Recently, organic nanoparticles of bifenthrin, a pyrethroid insecticide
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Phytochemical and biological characterization of aqueous extract of Vassobia breviflora on proliferation and viability of melanoma cells: involvement of purinergic pathway J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-07-11 Altevir Rossato Viana, Nathieli Bianchin Bottari, Vinícius Rodrigues Oviedo, Daniel Santos, James Eduardo Lago Londero, Maria Rosa Chitolina Schetinger, Erico Marlon Moraes Flores, Aline Pigatto, André Passaglia Schuch, Alexandre Krause, Luciana Maria Fontanari Krause
ABSTRACT Vassobia breviflora belongs to the Solanaceae family, possessing biological activity against tumor cells and is a promising alternative for therapy. The aim of this investigation was to determine the phytochemical properties V. breviflora using ESI-ToF-MS. The cytotoxic effects of this extract were examined in B16-F10 melanoma cells and the relationship if any to purinergic signaling was involved
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Spawning time in adult polar cod (Boreogadus saida) altered by crude oil exposure, independent of food availability J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-07-03 Leah C. Strople, Ireen Vieweg, Fekadu Yadetie, Derrick Kwame Odei, Anders Thorsen, Odd André Karlsen, Anders Goksøyr, Lisbet Sørensen, Antonio Sarno, Bjørn Henrik Hansen, Marianne Frantzen, Øyvind J. Hansen, Velmurugu Puvanendran, Jasmine Nahrgang
ABSTRACT Fish early life stages are well known for their sensitivity to crude oil exposure. However, the effect of crude oil exposure on adults and their gametes during their spawning period is not well studied. Polar cod, a key arctic fish, may be at risk for crude oil exposure during this potentially sensitive life stage. Additionally, this species experiences lower food availability during their
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Phytochemical characterization, antioxidant and antibacterial activities of crude extracts of Anisomeles malabarica and Coldenia procumbens J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-07-03 Ramalingam Revathi, R. Akash, Ramasamy Mahadevi, Singaravel Sengottuvelu, Palanisamy Mohanraj, Natesan Vijayakumar, Rajapandiyan Krishnamoorthy, Mohammad Z. Ahmed, Shadab Kazmi, Ramamoorthy Kavitha
ABSTRACT The aim of this study was to determine the phytochemical profile, antibacterial and antioxidant activities of crude aqueous leaf extracts of Anisomeles malabarica and Coldenia procumbens. The predominant components present in these crude extracts of test plants identified using gas chromatography-mass spectrometry (GC-MS) analysis in both plant extracts were phytochemicals including flavonoids
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Toxicological safety, antioxidant activity and phytochemical characterization of leaf and bark aqueous extracts of Commiphora leptophloeos (Mart.) J.B. Gillett J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-06-23 Lucas Felipe de Melo Alcântara, Pedro Thiago da Silva, Quesya Mamede de Oliveira, Talita Giselly dos Santos Souza, Marllyn Marques da Silva, George Souza Feitoza, Wendeo Kennedy Costa, Maria Aparecida da Conceição de Lira, Cristiano Aparecido Chagas, Francisco Carlos Amanajás de Aguiar Júnior, Maria Tereza dos Santos Correia, Márcia Vanusa da Silva
ABSTRACT This study aimed to characterize the phytochemical profile of bark and leaves aqueous extract Commiphora leptophloeos, and conduct in vivo and in vitro assays to determine the presence of any toxicological consequences due to exposure. The phytochemical analysis was carried out using high-performance liquid chromatography (HPLC). The antioxidant activity was estimated utilizing DPPH free radical
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Inhalation of polycarbonate emissions generated during 3D printing processes affects neuroendocrine function in male rats J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-06-23 Kristine Krajnak, Mariana Farcas, Walter McKinney, Stacey Waugh, Kyle Mandler, Alycia Knepp, Mark Jackson, Diana Richardson, MaryAnne Hammer, Joanna Matheson, Treye Thomas, Yong Qian
ABSTRACT Three-dimensional (3D) printing of manufactured goods has increased in the last 10 years. The increased use of this technology has resulted in questions regarding the influence of inhaling emissions generated during printing. The goal of this study was to determine if inhalation of particulate and/or toxic chemicals generated during printing with polycarbonate (PC) plastic affected the neuroendocrine
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Absence of maternal-fetal adverse effects of Alternanthera littoralis P. Beauv. following treatment during pregnancy in mice J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-06-21 Giovana Corbucci Danti Rezende, Renata Coelho Rodrigues Noronha, Hudman Cunha Ortiz, Luís Adriano Santos do Nascimento, Silvia Cordeiro das Neves, Yasmin Lany Ventura Said, Adauto Lima Cardoso, Vanessa Albuquerque de Mescouto, Marcelo Luiz Brandão Vilela, Valter Aragão do Nascimento, Henrique Rodrigues Scherer Coelho, Candida Aparecida Leite Kassuya, Taise Fonseca Pedroso, Marcos José Salvador, Rodrigo
ABSTRACT Alternanthera littoralis P. Beauv is a plant native to Brazil that exhibits various beneficial activities including antioxidant, antibacterial, antifungal, antiprotozoal, anti-hyperalgesic, and anti-inflammatory properties. The aim of this study was to assess the impact of the ethanol extract of Alternanthera littoralis (EEAl) on reproductive outcomes, embryofetal development, and DNA integrity
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Comparing land cover and interior forests on contaminated land and the surrounding region: Oak Ridge Reservation as a case study J. Toxicol. Environ. Health Part A (IF 2.6) Pub Date : 2023-06-19 Joanna Burger, Michael Gochfeld, Neil Giffen, Kevin G. Brown, Monica Cortes, Kelly Ng, David. S. Kosson
ABSTRACT Pressure from expanding populations has resulted in a need for protection, reclamation, and restoration of damaged land to productive, beneficial health uses. The objective of this investigation was to 1) compare land cover on the Department of Energy (DOE) Oak Ridge Reservation (ORR) with the surrounding region, 2) select an indicator to evaluate ORR’s protection of ecological resources,