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Assessing the toxicity of pesticides exposure on hepatic miRNA-target gene alterations in rat liver tissues via molecular and integrated network bioinformatics analysis Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-12 Hakeemah Al-nakhle, Ahmed El-Tokhy, Heba Eltahir, Mohammed Almuayrifi, Mekky Abouzied, Khaled Abdelaal, Muayad Albadrani
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Promoting effect of low concentration strontium on photosynthetic performance of Chinese cabbage seedlings: Combined leaf characteristics, photosynthetic carbon assimilation and chlorophyll fluorescence Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-12 Erkun Chao, Mengmeng Wu, Dongxue Yue, Yongxue Yuan, Nianwei Qiu, Feng Zhou
Low concentration strontium (LC-Sr) can promote the growth of plants. In order to explore its promoting mechanism from the aspect of photosynthesis, the leaf characteristics, CO assimilation and chlorophyll (Chl) fluorescence kinetics were investigated with hydroponically LC-Sr-treated Chinese cabbage seedlings. After a 28-d treatment to SrCl at different concentrations (0.1, 0.2, 0.5, and 1.0 mmol L)
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Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-12 Yue Ma, Panpan Xu, Hengrui Xing, Yue Zhang, Tingting Li, Xueman Ding, Li Liu, Qiang Niu
Fluoride is known to induce nephrotoxicity; however, the underlying mechanisms remain incompletely understood. Therefore, this study aims to explore the roles and mechanisms of lysosomal membrane permeabilization (LMP) and the GSDME/HMGB1 axis in fluoride-induced nephrotoxicity and the protective effects of rutin. Rutin, a naturally occurring flavonoid compound known for its antioxidative and anti-inflammatory
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Production and release of 2-MIB in Pseudanabaena: Effects of growth phases on cell characteristics and 2-MIB yield Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-11 Hailing Wang, Lin Li, Shaozhe Cheng, Liang Chen, Haiyang Zhang, Xuezhi Zhang
2-methylisoborneol (2-MIB), a secondary metabolite produced by cyanobacteria, often causes a musty odour in water, threatening the safety of drinking water supplies. This study investigated the effects of the growth phases on the production of 2-MIB by The effects of cell characteristics on the production and release of 2-MIB were also explored. The total 2-MIB concentration increased during the exponential
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Periodic DFT calculations for the heterogeneous formation of 2-chlorothiophenoxy radical from 2-chlorothiophenol on Cu(111) surface in fly ash Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-11 Xiaotong Wang, Yanan Han, Mohammad Hassan Hadizadeh, Wei Wang, Qi Zhang, Yongxia Hu, Fei Xu, Yanhui Sun, Wenxing Wang
Copper plays a crucial role in the heterogenous dissociation of chlorothiophenols (CTPs) to form chlorothiophenoxy radicals (CTPRs), which is the initial and critical step in the formation of polychlorinated thianthrenes/dibenzothiophenes (PCTA/DTs). Here, first-principles calculations were performed to investigate the activity of Cu(111) surface towards the formation of adsorbed 2-CTPR from 2-CTP
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LC-MS based untargeted metabolomics studies of the metabolic response of Ginkgo biloba extract on arsenism patients Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-11 Weiwei Li, Xiong Chen, Maolin Yao, Baofei Sun, Kai Zhu, Wenjuan Wang, Aihua Zhang
Arsenic is an environmentally ubiquitous toxic metalloid. Chronic exposure to arsenic may lead to arsenicosis, while no specific therapeutic strategies are available for the arsenism patients. And extract (GBE) exhibited protective effect in our previous study. However, the mechanisms by which GBE protects the arsenism patients remain poorly understood. A liquid chromatography-mass spectrometry (LC-MS)
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Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-11 Bo Jiao, Hua Zhang, Haiqin Jiang, Shuai Liu, Yican Wang, Yuanyuan Chen, Huawei Duan, Yong Niu, Meili Shen, Hongsheng Wang, Yufei Dai
Trichloroethylene (TCE)-induced hypersensitivity syndrome (THS) has been a concern for many researchers in the field of environmental and occupational health. Currently, there is no specific treatment for THS, leaving patients to contend with severe infections arising from extensive skin lesions, consequently leading to serious adverse effects. However, the pathogenesis of severe skin damage in THS
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Chromium immobilization from wastewater via iron-modified hydrochar: Different iron fabricants and practicality assessment Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-11 Ting Cui, Song Yan, Yu Ding, Shaopeng Lin, Qiuliang Chen, Ying Hou, Lin Ding, Huabin Wang, Rui Xu
The recycling of industrial solid by-products such as red mud (RM) has become an urgent priority, due to their large quantities and lack of reutilization methods can lead to resource wastage. In this work, RM was employed to fabricate green hydrochar (HC) to prepare zero-valent iron (ZVI) modified carbonous materials, and conventional iron salts (IS, FeCl) was applied as comparison, fabricated HC labeled
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Maternal exposure to deltamethrin during pregnancy and lactation impairs neurodevelopment of male offspring Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-10 Fei Hao, Ye Bu, Shasha Huang, Wanqi Li, Huiwen Feng, Yuan Wang
Deltamethrin (DM) is a highly effective and widely used pyrethroid pesticide. It is an environmental factor affecting public and occupational health and exerts direct toxic effects on the central nervous system. As the major target organs for neurotoxicity of DM, the hippocampus and the cerebellum are critical to the learning and motor function. Pregnant Wistar rats were randomly divided into four
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Dietary exposure to 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) induces oxidative damage promoting cell apoptosis primarily via mitochondrial pathway in the hepatopancreas of carp, Cyprinus carpio Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-10 Xin Zhang, Yujie Huang, Lei Yang, Shuhuang Chen, Youlian Liu, Ni Tang, Zhiqiong Li, Xiaoli Zhang, Liangyu Li, Defang Chen
To investigate the mechanisms of BDE-47 on hepatotoxicity in fish, this study examined the effects of dietary exposure to BDE-47 (40 and 4000 ng/g) on carp for 42 days. The results showed that BDE-47 significantly increased carp’s condition factor and hepatosomatic index. Pathological results revealed unclear hepatic cord structure, hepatocytes swelling, cellular vacuolization, and inflammatory cell
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Corrigendum to “Comparison of antibiotic-resistant Escherichia coli and extra-intestinal pathogenic E. coli from main river basins under different levels of the sewer system development” [Ecotoxicol. Environ. Saf., 2023, 263, 115372] Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-10 Jung-Sheng Chen, Bing-Mu Hsu, Wen-Chien Ko, Jiun-Ling Wang
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Biodegradable microplastics: Uptake by and effects on the rockpool shrimp Palaemon elegans (Crustacea: Decapoda) Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-10 Lukas Miksch, Chiau Yu Chen, Maria E. Granberg, Anna-Sara Krång, Lars Gutow, Reinhard Saborowski
Ingestion of microplastics can lead to deleterious consequences for organisms, as documented by numerous laboratory studies. The current knowledge is based on a multitude of effect studies, conducted with conventional fossil-based and non-degradable plastics. However, there is a lack of information about the acceptance and the effects of novel bio-based and biodegradable plastics. Biodegradable plastics
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Joint and interactive effects of metal mixtures on liver damage: Epidemiological evidence from repeated-measures study Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-10 Guohuan Yin, Shuanzheng Zhao, Meiduo Zhao, Jing Xu, Xiaoyu Ge, Jingtao Wu, Yifan Zhou, Xiaolin Liu, Lanping Wei, Qun Xu
The impact of heavy metals on liver function has been examined in numerous epidemiological studies. However, these findings lack consistency and longitudinal validation. In this study, we conducted three follow-up surveys with 426 participants from Northeast China. Blood and urine samples were collected, along with questionnaire information. Urine samples were analyzed for concentrations of four metals
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Chlorocholine chloride exposure induced spermatogenic dysfunction via iron overload caused by AhR/PERK axis-dependent ferritinophagy activation Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-09 Wanqian Guo, Chenping Kang, Xiaoxia Wang, Haoran Zhang, Lilan Yuan, Xuetao Wei, Qianqian Xiao, Weidong Hao
Chlorocholine chloride (CCC) is a plant growth regulator used worldwide that is detectable in cereals, fruits and animal products. The health effects of CCC exposure have raised public concern. Our previous research showed that CCC exposure decreased testosterone synthesis in pubertal rats. However, little is known about whether and how pubertal CCC exposure impacts spermatogenesis. In this study,
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Pubertal exposure to Microcystin-LR arrests spermatogonia proliferation by inducing DSB and inhibiting SIRT6 dependent DNA repair in vivo and in vitro Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-09 Yu-lin Liu, Jia-yu Liu, Xin-xin Zhu, Jian-hua Wei, Shuang-ling Mi, Su-ya Liu, Xiu-liang Li, Wei-wei Zhang, Ling-li Zhao, Hua Wang, De-xiang Xu, Lan Gao
The reproduction toxicity of pubertal exposure to Microcystin-LR (MC-LR) and the underlying mechanism needs to be further investigated. In the current study, pubertal male ICR mice were intraperitoneally injected with 2 μg/kg MC-LR for four weeks. Pubertal exposure to MC-LR decreased epididymal sperm concentration and blocked spermatogonia proliferation. studies found MC-LR inhibited cell proliferation
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Heavy metals pollution from smelting activities: A threat to soil and groundwater Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-09 Muhammad Adnan, Baohua Xiao, Muhammad Ubaid Ali, Peiwen Xiao, Peng Zhao, Haiyan Wang, Shaheen Bibi
Throughout the literature, the word "heavy metal" (HM) has been utilized to describe soil contamination; in this context, we characterize it as those elements with a density greater than 5 g per cubic centimeter. Contamination is one of the major global health concerns, especially in China. China's rapid urbanization over the past decades has caused widespread urban water, air, and soil degradation
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Triphenyltin induced darker body coloration by disrupting melanocortin system and pteridine metabolic pathway in a reef fish, Amphiprion ocellaris Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-09 Song Liu, Yu Hou, Ya-jun Shi, Nan Zhang, Yi-guang Hu, Wen-ming Chen, Ji-liang Zhang
Triphenyltin (TPT) is a typical persistent organic pollutant whose occurrence in coral reef ecosystems may threaten the survival of reef fishes. In this study, a brightly colored representative reef fish, was used to explore the effects of TPT at environmental levels (1, 10, and 100 ng/L) on skin pigment synthesis. After the fish were exposed to TPT for 60 days, the skin became darker, owing to an
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Identification of endocrine-disrupting chemicals targeting key DCM-associated genes via bioinformatics and machine learning Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-09 Shu Li, Shuice Liu, Xuefei Sun, Liying Hao, Qinghua Gao
Dilated cardiomyopathy (DCM) is a primary cause of heart failure (HF), with the incidence of HF increasing consistently in recent years. DCM pathogenesis involves a combination of inherited predisposition and environmental factors. Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with endogenous hormone action and are capable of targeting various organs, including the heart
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Unexpected role of pig nostrils in the clonal and plasmidic dissemination of extended-spectrum beta-lactamase-producing Escherichia coli at farm level Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-09 Sandra Martínez-Álvarez, Pierre Châtre, Pauline François, Idris Nasir Abdullahi, Carmen Simón, Myriam Zarazaga, Jean-Yves Madec, Marisa Haenni, Carmen Torres
The presence of methicillin-resistant or -susceptible in pig nostrils has been known for a long time, but the occurrence of extended-spectrum beta-lactamase (ESBL)-producing has hardly been investigated. Here, we collected 25 recovered from nasal samples of 40 pigs/10 farmers of four farms. Nine ESBL-producing isolates belonging to ST48, ST117, ST847, ST5440, ST14914 and ST10 were retrieved from seven
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Rapid discovery of a new antifoulant: From in silico studies targeting barnacle chitin synthase to efficacy against barnacle settlement Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-08 Zhixuan Wang, Shanshan Yao, Zhaofang Han, Zhuo Li, Zhiwen Wu, Huanhuan Hao, Danqing Feng
Due to the adverse environmental impacts of toxic heavy metal–based antifoulants, the screening of environmentally friendly antifoulants has become important for the development of marine antifouling technology. Compared with the traditional lengthy and costly screening method, computer-aided drug design (CADD) offers a promising and efficient solution that can accelerate the screening process of green
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Interaction of titanium dioxide nanoparticles with PVC-microplastics and chromium counteracts oxidative injuries in Trachyspermum ammi L. by modulating antioxidants and gene expression Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-08 Jing Ma, Ziyi Hua, Yanfeng Zhu, Muhammad Hamzah Saleem, Faisal Zulfiqar, Fu Chen, Touqeer Abbas, Mohamed A. El-Sheikh, Jean Wan Hong Yong, Muhammad Faheem Adil
The emergence of polyvinyl chloride (PVC) microplastics (MPs) as pollutants in agricultural soils is increasingly alarming, presenting significant toxic threats to soil ecosystems. Ajwain ( L.), a plant of significant medicinal and culinary value, is increasingly subjected to environmental stressors that threaten its growth and productivity. This situation is particularly acute given the well-documented
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Corrigendum to “A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway” [Ecotoxicol. Environ. Saf. 249 (2023) 114410] Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-08 Yangyang Tian, Jiarui Xia, Guo Yang, Chao Li, Yuanmeng Qi, Kai Dai, Chenchen Wu, Yonghua Guo, Wu Yao, Changfu Hao
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Effects of dietary arsenic exposure on liver metabolism in mice Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-08 Junli Shao, Chengze Lai, Qiuyi Zheng, Yu Luo, Chengji Li, Bin Zhang, Yanqin Sun, Shizhen Liu, Yingying Shi, Jinglin Li, Zuguo Zhao, Lianxian Guo
Arsenic, a ubiquitous environmental toxicant with various forms and complex food matrix interactions, can reportedly exert differential effects on the liver compared to drinking water exposure. To examine its specific liver-related harms, we targeted the liver in C57BL/6 J mice (n=48, 8-week-old) fed with arsenic-contaminated food (30 mg/kg) for 60 days, mimicking the rice arsenic composition observed
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Combined effects of polystyrene nanoplastics and lipopolysaccharide on testosterone biosynthesis and inflammation in mouse testis Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-08 Yanli Li, Yingqi Liu, Yanhong Chen, Chenjuan Yao, Shali Yu, Jianhua Qu, Gang Chen, Haiyan Wei
Microplastics (MPs)/nanoplastics (NPs), as a source and vector of pathogenic bacteria, are widely distributed in the natural environments. Here, we investigated the combined effects of polystyrene NPs (PS-NPs) and lipopolysaccharides (LPS) on testicular function in mice for the first time. 24 male mice were randomly assigned into 4 groups, control, PS-NPs, LPS, and PS-NPs + LPS, respectively. Histological
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Evidence for chromium crosses blood brain barrier from the hypothalamus in chromium mice model Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-08 Jiuyang Ding, Baofei Sun, Yingdong Gao, Juan Zheng, Changyou Liu, Jian Huang, Nannan Jia, Xianglin Pei, Xueyu Jiang, Shanshan Hu, Bing Xia, Yunle Meng, Zhuihui Dai, Xiaolan Qi, Jiawen Wang
It has been shown that exposure to hexavalent Chromium, Cr (Ⅵ), via nasal cavity can have neurotoxicological effects and induces behavioral impairment due to the fact that blood brain barrier (BBB) does not cover olfactory bulb. But whether Cr (Ⅵ) can cross the BBB and have a toxicological effects in central nervous system (CNS) remains unclear. Therefore, we investigated the effects of Cr (Ⅵ) on mice
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Tissue damage, antioxidant capacity, transcriptional and metabolic regulation of red drum Sciaenops ocellatus in response to nanoplastics exposure and subsequent recovery Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-08 Zhicheng Sun, Linlin Zhao, Xin Peng, Meng Yan, Shaoxiong Ding, Jiachen Sun, Bin Kang
Nanoplastics are recognized as emerging contaminants that can cause severe toxicity to marine fishes. However, limited researches were focusing on the toxic effects of nanoplastics on marine fish, especially the post-exposure resilience. In this study, red drum () were exposed to 5 mg/L polystyrene nanoplastics (100 nm, PS-NPs) for a 7-day exposure experiment, and a 14-day recovery experiment that
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Urban airborne PM2.5 induces pulmonary fibrosis through triggering glycolysis and subsequent modification of histone lactylation in macrophages Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-08 Jingyi Li, Guodong Zeng, Zezhong Zhang, Yuanli Wang, Mengyao Shao, Chunjiang Li, Zhongbing Lu, Yong Zhao, Fang Zhang, Wenjun Ding
Airborne fine particulate matter (PM) can cause pulmonary inflammation and even fibrosis, however, the underlying molecular mechanisms of the pathogenesis of PM exposure have not been fully appreciated. In the present study, we explored the dynamics of glycolysis and modification of histone lactylation in macrophages induced by PM-exposure in both models. Male C57BL/6 J mice were anesthetized and administrated
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Corrigendum to “Electromagnetic field exposure-induced depression features could be alleviated by heat acclimation based on remodeling the gut microbiota,” [Ecotoxicol. Environ. Saf., 228 (2021) 112980] Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-07 X, u, e, s, e, n, , Y, a, n, g
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Potential AhR-independent mechanisms of 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of human glioblastoma A172 cells migration Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-07 Yiyun Liu, Ruihong Zhu, Tuan Xu, Yangsheng Chen, Yuan Ding, Sijia Zuo, Li Xu, Heidi Qunhui Xie, Bin Zhao
The toxicity of 2,3,7,8-Tetrachlorodibenzo--dioxin (TCDD) is generally believed to be mediated by aryl hydrocarbon receptor (AhR), but some evidence suggests that the effects of TCDD can also be produced through AhR-independent mechanisms. In previous experiments, we found that mainly AhR-dependent mechanism was involved in the migration inhibition of glioblastoma U87 cells by TCDD. Due to the heterogeneity
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Correlation of skin color and plasma carotenoid-related metabolites of ornamental koi carp under temperature fluctuations Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-07 Lili Liu, Xiaowen Wang, Rong Zhang, Huijuan Li, Hua Zhu
The skin color of koi carp ( L.) is one of the traits that most influence their ornamental and economic values. The present study suggested the effects of temperature fluctuation on koi carp in terms of skin color and plasma carotenoids and related-metabolites. The main results were as follows. (1) The vulnerability of koi skin color to acute temperature stress was in the order of white koi> black
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Per- and polyfluoroalkyl substances inhibit human and rat 17β-hydroxysteroid dehydrogenase 1: Quantitative structure-activity relationship and molecular docking analysis Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-06 Chao Wen, Huan Chen, Yunbing Tang, Hang Lin, Congcong Xu, Yingfen Ying, Yang Zhu, Xinjun Miao, Ren-shan Ge, Chao Chen, Shangqin Chen
Per- and polyfluoroalkyl (PFAS) substances are enduring industrial materials. 17β-Hydroxysteroid dehydrogenase isoform 1 (17β-HSD1) is an estrogen metabolizing enzyme, which transforms estrone into estradiol in human placenta and rat ovary. Whether PFAS inhibit 17β-HSD1 and what the structure-activity relationship (SAR) remains unexplored. We screened 18 PFAS for inhibiting human and rat 17β-HSD1 in
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Perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell-derived cardiomyocytes Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-06 Moon Yi Ko, Sun-Hwa Chon, Heejin Park, Euijun Min, Younhee Kim, Sin-Woo Cha, Joung-Wook Seo, Byoung-Seok Lee, Minhan Ka, Sung-Ae Hyun
Perfluorooctanoic acid (PFOA), commonly found in drinking water, leads to widespread exposure through skin contact, inhalation, and ingestion, resulting in detectable levels of PFOA in the bloodstream. In this study, we found that exposure to PFOA disrupts cardiac function in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). We observed reductions in field and action potentials
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Computational methods meet in vitro techniques: A case study on fusaric acid and its possible detoxification through cytochrome P450 enzymes Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-05 Lorenzo Pedroni, Daniel Zocchi Doherty, Chiara Dall’Asta, Gianni Galaverna, Stephen G. Bell, Luca Dellafiora
Mycotoxins are known environmental pollutants that may contaminate food and feed chains. Some mycotoxins are regulated in many countries to limit the trading of contaminated and harmful commodities. However, the so-called emerging mycotoxins are poorly understood and need to be investigated further. Fusaric acid is an emerging mycotoxin, noxious to plants and animals, but is known to be less toxic
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Single-cell RNA-sequencing of cellular heterogeneity and pathogenic mechanisms in paraquat-induced Parkinson's disease with depression Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-05 Yali Weng, Yu Zhang, Yinhan Li, Xinpei Lin, Zhenkun Guo, Hong Hu, Wenya Shao, Guangxia Yu, Fuli Zheng, Ping Cai, Huangyuan Li, Siying Wu
Parkinson's disease (PD) is among the most prevalent neurodegenerative diseases, and approximately one third of patients with PD are estimated to have depression. Paraquat (PQ) exposure is an important environmental risk factor for PD. In this study, we established a mouse model of PQ-induced PD with depression to comprehensively investigate cellular heterogeneity and the mechanisms underlying the
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Associations between maternal serum neonicotinoid pesticide exposure during pregnancy and newborn telomere length: Effect modification by sampling season Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-05 Changhui Mu, Mengrui Lin, Yantao Shao, Qian Liao, Jun Liang, Chuanxiang Yu, Xiaolin Wu, Manlin Chen, Ying Tang, Lihong Zhou, Xiaoqiang Qiu, Dongxiang Pan, Dongping Huang
An increasing amount of evidence suggests that telomere length (TL) at birth can predict lifespan and is associated with chronic diseases later in life, but newborn TL may be affected by environmental pollutants. Neonicotinoids (NEOs) are widely used worldwide, and despite an increasing number of studies showing that they may have adverse effects on birth in mammals and even humans, few studies have
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Long-term exposure to air pollutants and new-onset migraine: A large prospective cohort study Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-04 Hao-Jian Dong, Peng Ran, Dan-Qing Liao, Xiao-Bo Chen, Guo Chen, Yan-Qiu Ou, Zhi-Hao Li
Short-term exposure to air pollutants increases the risk of migraine, but the long-term impacts of exposure to multiple pollutants on migraine have not been established. The aim of this large prospective cohort study was to explore these links. A total of 458,664 participants who were free of migraine at baseline from the UK Biobank were studied. Cox proportional hazards models were used to estimate
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Rh proteins and H+ transporters involved in ammonia excretion in Amur Ide (Leuciscus waleckii) under high alkali exposure Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-02 Xue Fei Zhao, Jing Huang, Wen Li, Shuang Yi Wang, Li Qun Liang, Li Min Zhang, Hon Jung Liew, Yu Mei Chang
High alkaline environment can lead to respiratory alkalosis and ammonia toxification to freshwater fish. However, the Amur ide (), which inhabits an extremely alkaline lake in China with titratable alkalinity up to 53.57 mM (pH 9.6) has developed special physiological and molecular mechanisms to adapt to such an environment. Nevertheless, how the Amur ide can maintain acid-base balance and perform
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Long-term di-(2-ethylhexyl) phthalate exposure reduces sorafenib treatment efficacy by enhancing mesenchymal transition in hepatocellular carcinoma Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-02 Ming-Syuan Shih, Fat-Moon Suk, Wan-Chun Chiu, Chun-Ya Lee, Fang-Yu Hsu, Yi-Jen Liao
Di(2-ethylhexyl) phthalate (DEHP) is a worldwide common plasticizer. Nevertheless, DEHP is easily leached out to the environment due to the lack of covalent bonds with plastic. High dose of DEHP exposure is often observed in hemodialysis patients because of the continual usage of plastic medical devices. Although the liver is the major organ that catabolizes DEHP, the impact of long-term DEHP exposure
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Comparison of physiological and transcriptome responses of corals to strong light and high temperature Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-02 Shuwen Jia, Xiaoxiao Geng, Zefu Cai, Yi Wang, Jie Shen, Yuanchao Li, Zhongjie Wu, Shiquan Chen, Daoru Wang
Coral reefs are essential for marine ecology and biodiversity. Global climate change has resulted in severe coral reef degradation, partly via coral bleaching, which is caused by rising sea temperatures and solar light intensity. In this study, we examined the impact of strong light (300 µmol.m.s) and high temperature (33°C) on the growth, immunity, and gene expression of . Strong light caused coral
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Exogenous titanium dioxide nanoparticles alleviate cadmium toxicity by enhancing the antioxidative capacity of Tetrastigma hemsleyanum Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-01 Yuqing Huang, Shengguan Cai, Wu Ying, Tianxin Niu, Jianli Yan, Hongliang Hu, Songlin Ruan
Nanotechnology is one of the most recent approaches employed to defend plants against both biotic and abiotic stress including heavy metals such as Cadmium (Cd). In this study, we evaluated the effects of titanium dioxide (TiO) nanoparticles (TiO NPs) in alleviating Cd stress in Diels et Gilg. Compared with Cd treatment, TiO NPs decreased leaf Cd concentration, restored Cd exposure-related reduction
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The mechanism of nickel-induced autophagy and its role in nephrotoxicity Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-01 Heng Yin, Chengbi Wang, Hongrui Guo, Xiaocong Li, Jingbo Liu
Nickel (Ni), an environmental health hazard, is nephrotoxic to humans, but the exact mechanism is unknown. This study aims to identify whether nephrotoxicity is associated with autophagy. Here, nickel chloride (NiCl) increased autophagy in TCMK-1 cells. NiCl induces autophagy through Akt and AMPK/mTOR pathways. Next, oxidative stress was investigated in NiCl-induced autophagy. The findings demonstrated
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Bacillus cereus G2 alleviate salt stress in Glycyrrhiza uralensis Fisch. by balancing the downstream branches of phenylpropanoids and activating flavonoid biosynthesis Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-01 Xiang Xiao, Duoyong Lang, Jingjiao Yong, Xinhui Zhang
The salinity environment is one of the biggest threats to Fisch. () growth, resulting from the oxidative stress caused by excess reactive oxygen species (ROS). Flavonoids are the main pharmacodynamic composition and help maintain ROS homeostasis and mitigate oxidative damage in in the salinity environment. To investigate whether endophytic G2 can improve the salt-tolerance of through controlling flavonoid
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Metagenomic analysis revealed N-metabolizing microbial response of Iris tectorum to Cr stress after colonization by arbuscular mycorrhizal fungi Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-03-01 Sixi Zhu, Wei Zhao, Suxia Sun, Xiuqin Yang, Huan Mao, Luying Sheng, Zhongbing Chen
Arbuscular mycorrhizal fungi (AMF) and plant growth-promoting bacteria enhance plant tolerance to abiotic stress and promote plant growth in contaminated soil. However, the interaction mechanism between rhizosphere microbial communities under chromium (Cr) stress remains unclear. This study conducted a greenhouse pot experiment and metagenomics analysis to reveal the comprehensive effects of the interaction
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Evaluation of multiple organophosphate insecticide exposure in relation to altered thyroid hormones in NHANES 2007‐2008 adult population Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-29 Massira Ousseni Diawara, Songtao Li, Mingzhi Zhang, Francis Manyori Bigambo, Xu Yang, Xu Wang, Tianyu Dong, Di Wu, Chenghao Yan, Yankai Xia
The thyroid gland is susceptible to chemical exposure such as organophosphate insecticides (OPIs). With the ubiquitous nature of these products, humans are simultaneously exposed to a multitude of chemicals. This study aimed to evaluate the association between an individual and a mixture of OPI metabolites and changes in serum thyroid hormone (TH) concentrations. The analyzed data were 1,434 participants
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Sulfamethoxazole stress endangers the gut health of sea cucumber (Apostichopus japonicus) and affects host metabolism Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-29 Honglin Pei, Luo Wang, Xinglong Xia, Changkun Dong, Bamei Tan, Yanmin Zhang, Zhiping Lin, Jun Ding
Sulfamethoxazole (SMZ) is a frequently detected antibiotic in the environment, and there is a growing concern about its potential toxic effects on aquatic organisms. sea cucumber () is a benthic invertebrate whose gut acts as a primary immune defense and serves critical protective barrier. In this study, growth performance, histology, gut microbiota, and metabolomics analyses were performed to investigate
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Stereoselective bioaccumulation and degradation of chiral pesticide hexythiazox in earthworm-soil microcosm Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-28 Ningying Song, Jiyang Zhuang, Hu Zhang, Mingrong Qian, Huizhen Wu, Nabo Sun
The chiral pesticide hexythiazox was extensively employed in agricultural activities and has garnered growing concern for its harmful impact on the ecosystem. This study investigates the toxicodynamic earthworm at the enantiomeric level of hexythiazox. Earthworms exhibited notable enantioselectivity during the accumulation stage. Furthermore, the presence of earthworms can impact the rate of degradation
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Toxicological impacts of microplastics on virulence, reproduction and physiological process of entomopathogenic nematodes Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-28 Mingge Li, Bingjun Ha, Yuchen Li, Klaas Vrieling, Zhen Fu, Qilin Yu, Sergio Rasmann, Xianqin Wei, Weibin Ruan
Microplastics have emerged as significant and concerning pollutants within soil ecosystems. Among the soil biota, entomopathogenic nematodes (EPNs) are lethal parasites of arthropods, and are considered among the most effective biological agents against pests. Infective juveniles (IJs) of EPNs, as they navigate the soil matrix scavenging for arthropod hosts to infect, they could potentially encounter
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Fate of Planktothrix-derived toxins in aquatic food webs: A case study in Lake Mindelsee (Germany) Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-28 Eva Riehle, Daniel G. Beach, Selina Multrus, Tarn Preet Parmar, Dominik Martin-Creuzburg, Daniel R. Dietrich
Blooms of the red, filamentous cyanobacterium occur frequently in pre-alpine lakes in Europe, often with concomitant toxic microcystin (MC) production. Trophic transfer of MCs has been observed in bivalves, fish, and zooplankton species, while uptake of MCs into species could facilitate distribution of MCs into terrestrial food webs and habitats. In this study, we characterized a bloom in summer 2019
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Fecal transplantation of young mouse donors effectively improves enterotoxicity in elderly recipients exposed to triphenyltin Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-27 Xiuxiu Chen, Donghui Zhu, Renshan Ge, Zhijun Bao
Triphenyltin (TPT) is a widely used biocide known for its high toxicity to various organisms, including humans, and its potential contribution to environmental pollution. The aging process leads to progressive deterioration of physiological functions in the elderly, making them more susceptible to the toxic effects of environmental pollutants. This study aimed to investigate the mitigating effect of
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Mechanism of KAT2A regulation of H3K36ac in manganese-induced oxidative damage to mitochondria in the nervous system and intervention by curcumin Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-27 Yan Liu, Jia-Min Zeng, Hua Zhao, Chun-Yan Ao, Li-Hong Ao, Jia-Qi Ban, Jun Li
Excessive exposure to manganese in the environment or workplace is strongly linked to neurodegeneration and cognitive impairment, but the precise pathogenic mechanism and preventive measures are still not fully understood. The study aimed to investigate manganese -induced oxidative damage in the nervous system from an epigenetic perspective, focusing on the H3K36ac-dependent antioxidant pathway. Additionally
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Mitophagy protects against silver nanoparticle–induced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-27 Jiangyan Li, Ming Li, Ruirui Wang, Jiaqi Lan, Lian Yu, Jie Gao, Hezuo Lü, Qiang Fang, Fengchao Wang
Silver nanoparticles (AgNPs) have wide clinical applications because of their excellent antibacterial properties; however, they can cause liver inflammation in animals. Macrophages are among the main cells mediating inflammation and are also responsible for the phagocytosis of nanomaterials. The NLRP3 inflammasome is a major mechanism of inflammation, and its activation both induces cytokine release
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Vertical stratification and seasonality of fecal indicator bacteria in New York City playground sandboxes Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-27 Alessandra C. Leri, G. Eliana Fassihi, Matthew J. Lundquist, Marjan Khan, Mariette L. Arguin
Sandboxes in public play spaces afford a crucial opportunity for urban children to engage in naturalistic play that fosters development of cognitive, social, and motor skills. As open pits, sandboxes in New York City public playgrounds are potentially exposed to fecal inputs from various sources, including wild and domestic animals. A longitudinal study of thirteen sandboxes located in public playgrounds
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Optimization of assay conditions to quantify ECOD activity in vivo in individual Daphnia magna. Assay performance evaluation with model CYP 450 inducers/inhibitors Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-27 András Ács, Attila W. Kovács, János Győri, Anna Farkas
Screening the activity of the cytochrome P450 (CYP450) mixed function oxidase system in aquatic invertebrates received seldom applications in ecotoxicology due to low baseline enzymatic activities characteristic for these organisms. In this study, an existing in vivo spectrofluorometric assay method based on quantifying the cytochrome P450 mediated conversion of 7-ethocycoumarin (EtC) used as substrate
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Do the same chlorinated organophosphorus flame retardants that cause cytotoxicity and DNA damage share the same pathway? Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-27 Shengwu Yuan, Hong Zhang, Shuhang Wang, Xia Jiang, Mei Ma, Yiping Xu, Yingnan Han, Zijian Wang
Organophosphorus flame retardants (OPFRs) have been frequently detected with relatively high concentrations in various environmental media and are considered emerging environmental pollutants. However, their biological effect and underlying mechanism is still unclear, and whether chlorinated OPFRs (Cl-OPFRs) cause adverse outcomes with the same molecular initial events or share the same key events
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A novel Zn2+-coordination fluorescence probe for sensing HPPD inhibitors and its application in environmental media and biological imaging Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-26 Panpan Chen, Chenyang Xu, Yang Qiu, Yi Wang
Mesotrione, topramezone, tembotrione, and sulcotrione are four types of 4-hydroxyphenylpyruvate dioxidase (HPPD) inhibitor herbicides that are extensively employed in agricultural practices, but their usage also leads to environmental pollution and poses risks to human health. A probe (E)−1-((2-(pyridin-2-yl) hydrazineylidene) methyl) naphthalen-2-ol (CHMN) based on chelation enhancement (CHEF) effect
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Paralytic shellfish toxins producing dinoflagellates cause dysbacteriosis in scallop gut microbial biofilms Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-26 Zhongcheng Wei, Liang Zhao, Shuaitao Wang, Lirong Chang, Jiaoxia Shi, Xiangfu Kong, Moli Li, Jinshui Lin, Weipeng Zhang, Zhenmin Bao, Wei Ding, Xiaoli Hu
Filter-feeding bivalves could accumulate paralytic shellfish toxins (PSTs) produced by harmful dinoflagellates through diet. Despite that bivalves are resistant to these neurotoxins due to possessing PST-resistant sodium channel, exposure to PSTs-producing dinoflagellates impair bivalve survival. We hypothesized that ingesting PSTs-PSTs-producing dinoflagellates may influence the gut microbiota, and
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Long-term music stimulating alleviated the inflammatory responses caused by acute noise stress on the immune organs of broilers by NF-κB signaling pathway Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-26 Haowen Wang, Yiwen Chai, Yandong Xu, Yulai Wang, Jianhong Li, Runxiang Zhang, Jun Bao
As an environmental enrichment, music can positively influence the immune function, while noise has an adverse effect on the physical and mental health of humans and animals. However, whether music-enriched environments mitigate noise-induced acute stress remains unclear. To investigate the anti-inflammatory effects of music on the immune organs of broiler chickens under conditions of early-life acute
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Analysis of landfill leachate promoting efficient application of weathered coal anaerobic fermentation Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-26 Bo Song, Hongyu Guo, Zhenhong Chen, Qiang Xu, Linyong Chen, Xiujia Bai
This research aimed to develop a new method for clean utilization and treatment of landfill leachate and solid waste weathered coal. Landfill leachate and weathered coal were adopted for combined anaerobic fermentation for methane production. The characteristics of microbial community, mechanism of biological methane production, and utilization characteristics of fermentation broth and solid residue
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Metabolome evidence of CKDu risks after chronic exposure to simulated Sri Lanka drinking water in zebrafish Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-26 Pan-Pan Jia, Yan Li, Lan-Chen Zhang, Ming-Fei Wu, Tian-Yun Li, De-Sheng Pei
It is still a serious public health issue that chronic kidney disease of uncertain etiology (CKDu) in Sri Lanka poses challenges in identification, prevention, and treatment. What environmental factors in drinking water cause kidney damage remains unclear. This study aimed to investigate the risks of various environmental factors that may induce CKDu, including water hardness, fluoride (HF), heavy
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Enhanced chromium and nitrogen removal by constructing a biofilm reaction system based on denitrifying bacteria preferential colonization theory Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-02-26 Yancheng Zhang, Pengcheng Sang, Kuan Wang, Jingyi Gao, Qiang Liu, Jihong Wang, Fangping Qian, Yilin Shu, Pei Hong
Understanding the developmental characteristics of microbial communities in biofilms is crucial for designing targeted functional microbial enhancements for the remediation of complex contamination scenarios. The strong prioritization effect of microorganisms confers the ability to colonize strains that arrive first dominantly. In this study, the auto-aggregating denitrifying bacterial strain YC-34