To speculate on human responses from animal studies, scale-up factors (body weight, lung volume, or lung surface area ratios) are currently used to extrapolate aerosol lung deposition from animal to human. However, those existing scale-up methods between animals and humans neglected two important inter-subject variability factors: (1) the effect of anatomical differences in respiratory systems from

This article presents a novel approach towards tackling the balance between filter efficiency and pressure drop by layering micro and nano fibres using melt and solution electrospinning. Polyamide fibre mats were fabricated by a prototype fibre printing apparatus, based on a combination of melt and solution electrospinning. Fibrous mats with favorable filtration performance characteristics were developed

How dust grains aggregate into planetesimals is still an open question. It is experimentally observed that binary collisions between micron-sized dust grains result in adhesion for collisions up to ∼1 ms-1. However, aggregates at scales ∼1 mm and above have been shown to exhibit fragmentation or bouncing at relevant collision velocities, resulting in a barrier preventing the formation of larger aggregates

Understanding the transmission phenomena of SARS-CoV-2 by virus-laden droplets and aerosols is of paramount importance for controlling the current COVID-19 pandemic. Detailed information about the lifetime and kinematics of airborne droplets of different size is relevant in order to evaluate hygiene measures like wearing masks but also social distancing and ventilation concepts for indoor environments

Scanning mobility particle sizer (SMPS) is widely used for particle number size distribution measurements of submicron particles. In this work, two TSI® SMPSs equipped with a soft X-ray neutralizer and a Kr-85 neutralizer, respectively, were operated in parallel to measure particle number size distributions of ambient air. An independent TSI® ultrafine condensation particle counter (CPC) was used as

Spark discharge nanoparticle generators (SDGs) employ the method of spark ablation to generate nanoparticles (NPs) in the gas phase. The material plume ablated from two bulk electrodes is quenched and carried away by a controlled gas flow. The electrical circuit needed to maintain sparking and the gas/aerosol handling are usually rather simple to implement, therefore many different SDG designs exist

Thin films deposited by conventional electrospray of volatile solutions often give rise to rough morphology consisting of “coffee rings” formed by individual sessile droplets. This is due to the long average inter-droplet distance and low merging probability of deposited droplets within the sprayed circular area. We present a quadrupole configuration to form a squeezing electric field that compresses

In this report, a flame spray pyrolysis setup has been examined with various in situ extraction methods of particle samples along the flame axis. First, two precursor formulations leading to the formation of iron oxide nanoparticles were used in a standardized SpraySyn burner system, and the final particle outcome was characterized by a broad range of established powder characterization techniques

Inhaled viral droplets may immediately be expelled and cause an escalating re-transmission. Differences in the deposition location of inhaled viral droplets may have a direct impact on the probability of virus expelling. This study develops a numerical model to estimate the region-specific deposition fractions for inhalable droplets (1–50 μm) in respiratory airways. The results identified a higher

The SAE International has published Aerospace Information Report (AIR) 6241 which outlined the design and operation of a standardized measurement system for measuring non-volatile particulate matter (nvPM) mass and number emissions from commercial aircraft engines. Prior to this research, evaluation of this system by various investigators revealed differences in nvPM mass emissions measurement on the

Differential Mobility Analyzers (DMA) have been studied for decades to classify a wide range of particle sizes. Its correct behavior is determined by the resolution, influenced by Brownian diffusion losses, distortions in the electric and flow field. The design configuration, especially inlets and outlets, can be a reason of these effects, affecting the DMA reliability. One of these configurations

Poly-dispersed particle resuspension by turbulent airflow was experimentally studied in a wind tunnel called BISE. The set-up was carefully validated to produce reference airflows with three absolute pressures and friction velocities values. Monolayer deposits of poly-dispersed tungsten particles on tungsten surfaces were used for the experiments. The fraction of detached particles by size bin from

Calibration of optical counters, condensation particle counters, electrical impactors, filtration efficiency measurement, heterogeneous condensation (and many other laboratory applications in aerosol science and technology) are widely used with singly charged particles classified by a differential mobility analyzer with particles smaller than 1 μm. Nevertheless the method presents an ambiguity because

Aerosol nanoclusters (AN), defined here as molecular aggregates suspended in a gas with dimensions between 2 and 10 nm, are the link between substances that we think of as molecules, or the “gas phase,” and those that we consider as particles, or the “condensed phase.” The ability to measure and model the physical and chemical properties of size-resolved AN, which at present is rudimentary at best

The Aerodynamic Aerosol Classifier (AAC) and Differential Mobility Analyzer (DMA) are aerosol classifiers commonly used to generate a monodispersed aerosol by selecting particles within a narrow range of relaxation times or electrical mobilities, respectively. However, generating an aerosol of homogeneous particles, which has narrow ranges of particle mass, mobility and relaxation time simultaneously

This pilot study evaluated the ability of a lung deposition sampler (LDS) to estimate body burden by comparing lung-deposited and inhalable nickel and chromium exposures to biomarkers of internal dose. A cohort of stainless steel welders (N = 18) wore side-by-side inhalable and lung deposition samplers for two Monday shifts and urine samples were collected pre- and post-shift. Samplers were analyzed

Accurate predictions of aerosol transport, evolution, and deposition in the human airways are crucial for inhalation dosimetry investigations. Inhaled aerosol transported through the airways undergoes thermodynamic changes due to changes in temperature and humidity. Aerosol evolution processes are particularly important for liquid multispecies aerosols. These aerosols are sensitive to condensation

Low-cost particle sensors are rapidly gaining popularity for indoor air quality monitoring, but their accuracy has been shown to vary among products and among environments in which they operate. Previous research has explored the effect of environmental conditions including temperature and humidity on sensor accuracy and found appreciable effects of these variables in many cases. We extend this work

The use of low-cost air pollution sensors mounted on drones is an exciting new approach to conduct affordable and highly resolved air quality measurements. However, the air flow around a drone consists of complex, unsteady turbulent structures which interact directly with ambient particulate matter and gases. These interactions influence the transport of fine particulate matter (e.g. PM2.5) and, subsequently

Inhalation exposure to environmental and occupational aerosol contaminants is associated with many respiratory health problems. To realistically mimic long-term inhalation exposure for toxicity testing, lung epithelial cells need to maintained and exposed under air-liquid interface (ALI) conditions for a prolonged period of time. In addition, to study cellular responses to aerosol particles, lung epithelial

Studies on the flow-induced particle resuspension have great significance for engineering applications of many areas, and several established resuspension models have been developed for the analysis of particle resuspension in an atmospheric environment. However, for flow with a non-negligible particle Knudsen number (the ratio between the mean free path of gas and the particle radius), which is commonly

Particle shape strongly influences the diffusion charging of aerosol particles exposed to bipolar/unipolar ions and accurate modeling is needed to predict the charge distribution of non-spherical particles. A prior particle-ion collision kernel βi model including Coulombic and image potential interactions for spherical particles is generalized for arbitrary shapes following a scaling approach that

In 2017, Assembly Bill 617 was approved in state of California, which mandated the allocation of resources for addressing air pollutant exposure disparities in underserved communities across the state. The bill stipulated the implementation of community scale monitoring and the development of local emissions reductions plans. We aimed to develop a streamlined, robust, and accessible PM2.5 exposure

Correlating data from in vitro dissolution testing of inhaled particulate pharmaceuticals or air pollutants with the dissolution and distribution to the blood circulation of the same aerosols following inhalation in vivo is a major challenge. Better methods could benefit both inhaled drug development and the risk assessment of air pollutants. Five properties known to influence the results produced

The resolidified fuel debris from the damaged Fukushima Daiichi reactors must be cut into small pieces prior to removing it from reactor buildings. Submicron radioactive aerosol particles are likely to be generated and dispersed into the primary containment vessel (PCV) atmosphere during this cutting process. However, traditional sprays cannot effectively scavenge aerosol particles with diameters in

Activities such as the suppression of coal dust would benefit from an improved understanding about how the presence of surfactant alters the charge distribution of spray drops. However, there is no standard method to measure charge and size distributions of nozzle-generated spray drops. To fill this gap, a new spray drop charge measurement system was developed to measure a broad range of sizes and

Particulate matter (PM) sensors are popular for distributed monitoring due to their portability, low-cost and networking capabilities. To provide reliable data, these sensors have to be calibrated periodically in the laboratory. This is often done in chambers with several of them co-located, alongside several research grade instruments. It is important to confirm that the aerosol is well distributed

Dynamic modeling of how particulate matter (PM) transport, deposit, and translocate from human respiratory systems to systemic regions subject to indoor and outdoor exposures are essential for case-specific lung dosimetry predictions and occupational health risk assessments. Because of the invasive nature and imaging resolution limitations of existing in vitro and in vivo methods, Computational Fluid-Particle

Electrical Mobility is arguably the property upon which some of the most successful classification criteria are based for aerosol particles and ions in the gas phase. Once the value of mobility is empirically obtained, it can be related to a geometrical descriptor of the charged entity through a size-mobility relationship. Given the multiscale range of sizes in the aerosol field, approaches that can

Structural properties in nonwoven materials, such as porosity and layer thickness, are typically spatially distributed on a micro- and mesoscale. The mesoscale inhomogeneity is visually perceived, inter alia, as the cloudiness of the nonwoven fabric or as inclusions in the bulk material. Differential box counting, which is a fractal based image analysis method, was used to assess the inhomogeneity

A recently described DMA designed for high resolution viral particle analysis (Perez-DMA; Perez-Lorenzo et al, 2020) is modified to decrease the relative peak full width at half maximum (FWHM) below previously achieved ≈3.3%. The electrode radii at the outlet slit (R1 = 1.01 cm; R2 = 2 cm) and the working length are almost unchanged (L = 114.9 vs. 116 mm). The laminarization trumpet and the radius

Gas phase nucleation is a universal phenomenon that plays a crucial role in both natural settings and industrial processes. Despite more than 100 years’ work to decipher this highly dynamic process, our understanding of nucleation remains incomplete. In particular, the formation, decay, and structures of the initially formed nucleating clusters critically determine the overall behavior of the nucleation

Traditional in vivo inhalation studies to inform hazard identification and risk assessment are time-intensive and financially expensive. Cell culture models combined with aerosol exposure systems have shown promise as surrogates in screening assays when multiple substances require preliminary information on hazard potential associated with aerosolized materials. This paper presents two different aerosol

We investigated a spray-drying aerosol generator that can generate micro-particles at high concentration using an ultrasonic nozzle. Unlike a conventional spray-drying aerosol generator that uses vertical spray with co-current sheath flow, we designed a new aerosol generator by using horizontal spray with co-current sheath flow combined with clean counter flow to increase particle generation efficiency

We report the photodegradation of optically trapped oleic acid droplets by visible light in the absence of additional reactive gaseous species. The temporal evolution of the droplet's chemical composition and size is monitored by Raman spectroscopy and elastic light scattering, respectively. The dependencies on the oxygen amount in the surrounding gas phase (~0–20%), the droplet size (~500–3000 nm

The transport and deposition of inhaled micron particles is largely determined by their inlet conditions, breathing rate, and the individual airway geometry. In this study, helical air-particle flow is introduced which significantly affects the particle dynamics with applications to targeted drug delivery. Specifically, helical flow, which reduces axial momentum, can be controlled by varying the swirl

A differential mobility analyzer along with a centrifugal particle mass analyzer was employed to study the effect of fuel type on effective density for nascent and non-volatile particles generated by a marine diesel engine. The engine was operated at 1500 rpm at loads between 10% and 100%. Three different fuels were evaluated: diesel fuel, distillate marine oil Grade A, and intermediate fuel oil. A

Hygroscopic growth of aerosols plays an important role in the characterization of atmospheric aerosols. Physico-chemical and optical properties of aerosols are dependent on relative humidity (RH) as well as on their size and composition. In this study, scattering enhancement factors, f(RH), for polydispersed aerosols were approximated. f(RH) of ammonium sulfate and ammonium nitrate (AS) and NaCl aerosols

The lack of quantitative risk assessment of airborne transmission of COVID-19 under practical settings leads to large uncertainties and inconsistencies in our preventive measures. Combining in situ measurements and computational fluid dynamics simulations, we quantify the exhaled particles from normal respiratory behaviors and their transport under elevator, small classroom, and supermarket settings

The potential airborne transmission of COVID-19 has raised significant concerns regarding the safety of musical activities involving wind instruments. However, currently, there is a lack of systematic study and quantitative information of the aerosol generation during these instruments, which is crucial for offering risk assessment and the corresponding mitigation strategies for the reopening of these

In vitro studies are the first step toward understanding the biological effects of particulate matter. As a more realistic exposure strategy than submerged culture approaches, air-liquid interface (ALI) in vitro exposure systems are gaining interest. One challenge with ALI systems is determining accurate particle mass deposition. Although a few commercially available ALI systems are equipped with online

Residential wood combustion, which is characterized by incomplete combustion, is a common source of particulate matter in suburban areas. This study investigated the usability of three different scattering-based particulate matter (PM) sensors and an absorption-based black carbon (BC) sensor in an environment impacted by wood combustion emissions. The measurement campaign, which lasted approximately