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Water Soluble Curcuminoids: Encapsulation into Cyclodextrins and In-vitro Antioxidant Properties Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-18 Suvarna Shenvi, L. Shruthi, G. Chandrasekara Reddy, Anil Kush
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Microbiological Monitoring in Analysis of Drug Quality Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-18 M. V. Roshchina, O. V. Gunar, N. G. Sakhno
An informational and analytical review regarding microbiological monitoring in the analysis of pharmaceutical product quality is presented. Regulated types of microbiological monitoring are considered. General approaches to conducting environmental monitoring and their possible advantages and disadvantages are analyzed. Domestic and foreign regulations on monitoring rules are studied. Factors having
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Creation of Modified Forms of Amiodarone with Glycyrrhizic Acid and Its Monoammonium Salt and Study of Their Cytotoxicity on Hela Cells Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-18 Kh. A. Yuldashev, R. S. Esanov, H. T. Saidullaeva, V. V. Uzbekov, M. K. Salakhutdinova, Z. S. Khashimova, M. B. Gafurov, Yu. I. Oshchepkova, Sh. I. Salikhov
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Effect of Phenolic Acids and Flavonoids on Low Dose Caffeine-Induced Adipogenesis and Oxidative Stress in 3T3-L1 Adipocytes Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-18
Obesity is characterised by an excessive build-up of lipids and triglycerides in adipocytes. Phenolic acids and flavonoids have previously been shown to inhibit body weight increase and fat buildup in mice. This study investigated the anti-obesity effect of phenolics, syringic (SYA) and sinapic acid (SIA) and flavonoids hesperidin (HD) and chrysin (CR) along with caffeine (CAF) on 3T3-L1 cells. Anti-obesity
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Biological Activities and Drug-Likeness Properties of Phenol-Based Heterocyclic Compounds Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-18
The widespread use of small molecules having heterocyclic rings to design anticancer agents, and the antioxidant potential of their phenolic conjugates led us to investigate phenol-based heterocyclic compounds’ anticancer, antioxidant activities, and drug-likeness properties. While compounds were evaluated in regards to cancer and non-cancer cell lines by the MTT method, antioxidant effects were carried
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Phenolic Contents, Enzyme Inhibitory Activities, and Protective Effect of Aqueous Extract of Rosa Pisiformis Fruits Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-17 Suat Ekin, Mahire Bayramoglu Akkoyun, Hatice Kiziltas, Hasya Nazlı Gok, Gokhan Oto, Turan Akkoyun, Fevzi Ozgokce, Didem Deliorman Orhan
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Liposomal Pharmaceutical Products: Methods of Analytical Characterization and Quality Control Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-17 Z. S. Shprakh, N. I. Burdaev, L. L. Nikolaeva, N. D. Bunyatyan
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Development and Validation of a Quantitative Determination Method for Fluorothiazinone in Human Blood Plasma Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-17
An HPLC-MS/MS technique for quantitative determination of the new antibacterial drug fluorothiazinone in human blood plasma using an internal standard was developed and validated. The validation protocol proved the selectivity, accuracy, and precision of the method and the lack of significant carryover, matrix, and sample-dilution effects. The calibration curve was linear in the concentration range
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In Vitro Study of the Cytotoxic and Immunotropic Effects of Molnupiravir and Favipiravir Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-16
The effects of the antiviral drugs molnupiravir and favipiravir on the viability of human embryonic lung cells and the production of cytokines by peripheral blood leukocytes of healthy donors and patients with coronavirus infections were studied. Neither molnupiravir nor favipiravir nor their combination at concentrations up to 60 μg/mL was shown to have a significant effect on the survival of human
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Imipenem/Cilastatin Plasma Concentrations and Survival (Efficacy of Therapy) of Critically Ill Patients in Clinical Practice Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-16 O. V. Zhukova, V. A. Sudakov, O. A. Vorobyeva, N. N. Chesnokova, N. L. Shimanovsky
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Dispersive Solid Phase Extraction/Back-Extraction Using Carbon Nanotubes as Sorbent for HPLC/UV Determination of Ibuprofen in Human Blood Serum Samples Pharm. Chem. J. (IF 0.9) Pub Date : 2024-03-15 L. Sheikhian, E. Zahedinejad
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Nicotine-Loaded Polyvinyl Alcohol Electrospun Nanofibers as Transdermal Patches for Smoking Cessation: Formulation and Characterization Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-08 Nurul Huda Kamsani, Muhammad Shamsuri Hasan, Kamal Rullah, Muhammad Salahuddin Haris
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Mononuclear Metal Complexes of Moxifloxacin with Antacids: Synthesis, Spectroscopic Characterization, and Antimicrobial Activities Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-07 Mahwish Akhtar, Muhammad Imran
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Ternary Solid Dispersion of Celecoxib Produced by the Solvent Method with Improved Solubility and Dissolution Properties Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-07
Celecoxib, the first cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug, has a wide range of pharmacological effects, including anti-inflammatory, antirheumatic and antitumor effects. However, celecoxib’s poor solubility severely limits its clinical application. Thus, a novel ternary solid dispersion system was developed using PVP K30 and hydroxypropyl-β-cyclodextrin (HPβCD) as carrier
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Development and Validation of the Ultra-Performance Liquid Chromatography Method for Quantification of Belzutifan in Pharmaceutical Dosage Form Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-06 Pridhvi Krishna Gaddey, Raja Sundararajan
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Features of Planning and Conducting Bioequivalence Studies with an Adaptive Design for Drug Analogs of Endogenous Compounds Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-06 N. N. Eremenko, D. V. Goryachev
There is a constant interest in the study of drugs that are analogs of endogenous compounds. Guidelines for conducting bioequivalence studies are being updated. Official regulators are holding seminars on the development and study of generic drugs. The goal of the present study is to analyze approved protocols of clinical bioequivalence studies with an adaptive design for drugs that are analogs of
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Chloroacetates of Substituted 1H-Indol-5-,6-,7-Ylamines and Their Antimicrobial Activity Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-06 S. A. Yamashkin, I. S. Stepanenko, A. I. Kiryutina, T. N. Platkova
Water-soluble 1H-indol-5-, 6-, 7-ylammonium chloroacetates were obtained from the reaction of substituted 1H-indol-5-, 6-, 7-ylamines with chloroacetic acid; identified based on PMR, UV, and mass spectra; and screened in the laboratory for antimicrobial activity. All the tested compounds could suppress the growth of microorganism test strains at various minimum inhibitory concentrations (MICs). The
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Sclareol: Isolation, Structural Modification, Biosynthesis, and Pharmacological Evaluation – A Review Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-06 Salman Jameel, Khursheed Ahmad Bhat
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On Antimicrobial Preservatives in Soft Dosage Forms Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05 L. V. Tsyganova, O. V. Gunar
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Synthesis, Structure, and Antiproliferative Activities of Complexes of Some Transition Metals with 5,7-Dichloro-8-Hydroxyquinoline-2-Carboxaldehyde-4-Phenyl-3-Thiosemicarbazone Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05 Pham Thi Hai Linh, Mai Phuong Chi, Le Phuong Thao, Ninh Thi Minh Giang, Le Thi Hong Hai
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Kinetics of Omeprazole Release from Enteric Dosage Forms of Different Manufacturers Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05 S. Yu. Serebrova, D. O. Kurguzova, L. M. Krasnykh, G. F. Vasilenko, E. Yu. Demchenkova, N. N. Eremenko, E. N. Kareva, A. B. Prokofiev
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Effect of Thioxypine and Its Components on Behavioral Despair in Potential Antidepressant Screening Tests Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05 I. A. Volchegorskii, I. Y. Miroshnichenko, A. I. Sinitskii, S. I. Grobovoi, L. M. Rassokhina, R. R. Mihajlov
The effect of thioxypine (2-ethyl-6-methylpyridinol-3-yl thioctate) and its acyl and alcohol components on the duration of behavioral despair (BD) in the mouse tail suspension test according to L. Steru, et al. and the forced swimming test of mice and rats according to R. Porsolt, et al. was studied. Amitriptyline (a reference antidepressant) was used as a reference BD-contractor. The impact of the
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Substituted 1,3,5-Triazine Heterocycles: Synthesis and Antibacterial Activity Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05 Archana Gahtori, Sarika Khandari, Shweta Pandey, Prashant Gahtori
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Determination of Biapenem in Human Blood Plasma by High-Performance Liquid Chromatography with UV Detection Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05 A. M. Kazanova, S. K. Zyryanov, M. S. Chenkurov
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GC-MS Bioactives Profiling, Antibacterial and Cytotoxic Potential of Jamun (Syzygium cumini L.) Extracts Against Food-Borne Pathogen Salmonella enteritidis Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05
Salmonellosis is a major food-borne disease in humans worldwide caused by Salmonella enteritidis. Currently, selected phytochemicals are gaining attention as effective substitute therapeutics for management and control of microbial drug resistance. The present investigation appraises the antibacterial and cytotoxic activities of seed and leaf extract from Syzygium cumini against Salmonella enteritidis
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Flavonoids from the Leaves of Chromolaena odorata and Their α-Glucosidase Inhibitory Activity Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05
The leaf water extracts of C. odorata are used as an antidiabetic herbal drug in traditional medicine. The aim of this study was to determine flavonoids in the MeOH leaf extract of Chromolaena odorata (L.) R. M. King and H. Robinson (syn. Eupatorium odoratum L.) in Vietnam and evaluate their a-glucosidase inhibitory activity. Ten compounds including six known flavonoids (2, 4–6, 9, and 10), two known
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Stability Indicating RP-UPLC Method for the Quantitative Determination of Degradation Impurities of Benidipine Hydrochloride & Metoprolol Succinate in Combined Dosage Form Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05 Pranavkumar Shah, Sanjay Hadiyal, Jaydeep Lalpara, Gaurang Dubal, Bhavin Dhaduk
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Study of the Immunomodulatory Effect of Polysaccharides Isolated from Seeds of Turnip BRASSICA RAPA Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05
The goal of this study was an evaluation of the immunomodulatory effect of polysaccharides isolated from the seeds of Brassica rapa. Apolysaccharide (BRP) consisting mainly of α-linked pyranose residues belonging to the arabinogalactan class was obtained. The number of antibody-forming cells (AFCs) per spleen increased to 9,160 ± 1477.06, 12,000 ± 3480.33, and 19,080 ± 12,391.6 [antibody-forming reaction
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Determination of Pinocembrin Content in Glycyrrhiza glabra L. Herbs by HPLC Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-05 V. A. Kurkin, O. A. Belova, A. R. Mubinov, M. V. Egorov
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Role of the Liver Capsule as a Traditional Medicine Formulation in the Treatment of Non-Alcoholic Fatty Liver Disease in Rats Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-03 Sogol Albooyeh, Ebrahim Khadem, Fereshteh Jeivad, Atefeh Monir Vaghefi, Gholamreza Hassanzadeh, Fatemeh Aliasl, Maryam Gholami, Shabnam Delasoud, Omid Sabzevari
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Synthesis, Antimicrobial, and DNA-Binding Evaluation of Novel Schiff Bases Containing Tetrazole Moiety And Their Ni(II) and Pt(II) Complexes Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-03 M. Ulular, N. Sarı, F. Han, H. Öğütcü, E. Hasanoğlu Özkan
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Comparative Study of the Quantitative Determination of Lappaconitine in Aconitum septentrionale by High-Performance Liquid Chromatography and Spectrophotometry Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-03 D. K. Mutalova, Sh. A. Otaeva, A. Z. Sadikov, Sh. Sh. Sagdullaev
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Protective Effect of Mangiferin on Blue Light-Induced Acute Damage of Retinal Pigment Epithelial 19 Cells Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-03
Photochemical damage to retinal pigment epithelial (RPE) cells is implicated in the pathogenesis of age-related macular degeneration. This study investigated the protective effect of mangiferin on RPE cells subjected to blue light-induced damage. Using human-derived acute RPE 19 (ARPE-19) cells as an in vitro model, we incubated ARPE-19 cells with mangiferin and subsequently subjected those cells to
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Antitumor Activity of Antiestrogen-Cytostatics and Their Binding Affinity with Estrogen Receptors Pharm. Chem. J. (IF 0.9) Pub Date : 2024-02-03 A. R. Dublin, A. V. Semeikin, T. A. Fedotcheva, N. L. Shimanovsky
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Development of a Quantitative Determination Technique for Ascorbic Acid in Medicines Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-16
A coordination compound of iron(III) ion with 1,10-phenanthroline, or the oxidized form of ferroin (OFF), which was obtained via the reaction of phenanthroline hydrochloride and iron(III) ammonium sulfate (3:1) in acidic solution and standardized by indirect iodometry, was proposed for use as a titrant for quantitative determination of ascorbic acid (AA) in drugs. The developed method for determining
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Targeted Synthesis of New 5-Phenyl-2-[(E)-Styryl]-1H-Pyrimidin-6-One Derivatives and Their Inhibitory Activity Toward SARS-CoV-2 Major (MPRO) and Papain-Like Proteases (PLPRO) Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-15
The use of the 5-phenyl-1H-pyrimidin-6-one scaffold in the search for biologically active compounds with antiviral activity based on the pyrimidin-4-one core present in endogenous substances and drugs was substantiated. The molecular activity and pharmacokinetic descriptors for styryl derivatives of N-substituted 5-phenyl-1H-pyrimidin-6-one were predicted in silico via the SwissADME web service. The
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Extraction and Identification of Triterpenoids from Atractylodes ovata (Thunb.) DC. Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-10 A. V. Myagchilov, L. I. Sokolova, K. S. Kulagina, R. V. Dudkin
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Design, Synthesis and Biological Evaluation of Amide Derivatives of Thiazolo[5,4-d]Pyrimidines as Cytotoxicity Agents for Human Cancer Cell Lines Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-10 V. Balaraju, E. Laxminarayana, S. Kalyani
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Coumarin: A Renowned Moiety for Gram-Negative Escherichia coli – a Review Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-10
Various investigational transcripts have proven the improved antibacterial effect of the potential coumarin core compound. Coumarin is a heterocyclic compound composed of benzene and pyrone rings and its derivatives are of wide scope because of their diverse biological activities. As E. coli is the most common human pathogen, resistance to this is of particular concern. No significant progress has
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Crystal Structure, Anticancer, and Antimicrobial Evaluation of a Novel Substituted Pyrazole Ligand and Its Co(II), Ni(II), and Zn(II) Complexes Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-10 K. Subin Kumar, V. N. Reena
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Effect of a Low-Molecular-Weight NGF Mimetic on a Combined High-Carbohydrate Diet/Streptozotocin-Induced Model of Type 2 Diabetes Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-09 S. V. Ivanov, R. U. Ostrovskaya, M. S. Demorzhi, I. B. Alchinova, T. A. Gudasheva
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Identification, Synthesis, and Characterization of Potential Dichloro Impurity: N,N-Dimethyl-3-Phenyl-2, 3-Dichloropropylamine in the Synthesis of Atomoxetine Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-08 Sateesh Kumar Pinninti, Sivaganesh Tene, Siva Rao T, Karteek Rao Amperayani, Uma Devi Parimi
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Development of Some Antiplatelet Salts as Drug Active Ingredients and Investigation Biological Activities Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-08 Harun Uslu, Basri Satilmiş, Ayşe Burçin Uyumlu, Begüm Nurpelin Sağlik, Serkan Levent, Yusuf Özkay, Metin Fikret Genç, Kadir Batçioğlu, Suat Kamişli, Kadriye Benkli
In this study, prasugrel and prasugrel salts: prasugrel + trans-1,2-cyclohexanedicarboxylic acid (1a), prasugrel + maleic acid (2a), prasugrel + citric acid (3a), prasugrel + oxalic acid (4a), and prasugrel + trometamol (5a) were synthesized and investigated for their biological activities. Ex vivo antiplatelet and in vitro cytotoxic activities were experimentally researched. Antiproliferative activity
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Co-Amorphous System (Paracetamol:Indomethacin): Investigations on Physical Stability and Intermolecular Interactions Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-08 Marouene Bejaoui, Rihem Djemi, Salah Kouass, Haykel Galai
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Development and Validation of a Stability-Indicating Related Substances RP-HPLC Method for Anagliptin and its Degradation Products Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-08 Rajendra S. Chavan, Abdul Ahad, Rajendra Phase, Qasim Ullah, Sabreena Yameen, Pathan Mohd Arif
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Prevention of the Drug Resistance of Helicobacter pylori with 8-Octyl Berberine by Increasing Membrane Permeability and Reducing Motility Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-08
Antibiotic resistance is a major problem in the treatment of Helicobacter pylori (H. pylori). Berberine (BBR) has proven to be a promising alternative, though it is less effective than antibiotics. Structurally modified BBR might improve the anti-H. pylori activity. In this study, 8-octyl berberine (OBBR), a BBR derivative, was investigated for the activity and mechanism of action against H. pylori
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Determination of Palladium as an Elemental Impurity in Ropivacaine Hydrochloride Monohydrate by Atomic Absorption Spectrometer Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-08 Ashish Kumar Pal, Sundararajan Raja
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Development of Industrial Technology of Inulin Production from Dandelion Roots (Taraxacum officinale Wigg.) Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-06 K. N. Nuridullaeva, E. S. Karieva, R. M. Khalilov
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Synthesis, Antitumor Activities, and Molecular Modeling of 4-Anilinoquinazoline Derivatives as EGFR-TK Inhibitors Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-06 Aya H. Mohammed, Rania M. Gomaa, Magda A.-A. El-Sayed, Khalid B. Selim
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High-Performance Thin-Layer Chromatography Fingerprinting Analysis and Hepatoprotective Effects of Scrophularia striata Aerial Parts Against Acetaminophen-Induced Acute Hepatotoxicity in Mice Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-05
The liver performs detoxification, making it vulnerable to damage by common hepatotoxic medicines such as acetaminophen. Finding new medicines to prevent and treat liver damage caused by hepatotoxic drugs is an important area of research. In this study, an Iranian endemic plant Scrophularia striata that belongs to the botanical family containing hepatoprotective compounds was selected for phytochemical
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Antifungal Activity of Silver Salts of Pyrrolo[3,4-c]Pyrazol-3-Ones and Pyrazol-3-Carboxamides Containing Sulfamide Groups Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-05 V. V. Novikova, O. V. Bobrovskaya, V. L. Gein
The antifungal activity of ten new silver salts of pyrrolo[3,4-c]pyrazol-3-ones and pyrazole-3-carboxamides containing sulfamide groups was studied. Data from in vitro studies and computer predictions of their biological activity were compared. The pharmacophores affecting the antifungal activity were identified. The compound with a 4-ethoxyphenyl substituent in the heterocycle 5-position exhibited
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Anti-Inflammatory, Wound Healing, and Hepatoprotective Effects of Ethanol Extract of Rice Bran in Rodent Models Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-05 Pritam Saha, Purba Islam, Kazi Rafiq, Rafiqul Islam, Atsushi Miyamoto, Md.Zahorul Islam
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Synthesis and Antibacterial and Antitumor Properties of Derivatives of 5,5-Dimethyl-3-iso-Propyl-2-Thioxo-2,3,5,6-Tetrahydrobenzo[h]Quinazoline-4(1H)-One Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-05 A. I. Markosyan, A. S. Baghdasaryan, A. S. Ayvazyan, S. H. Gabrielyan, M. Yu. Danghyan, F. H. Arsenyan, J. A. Avakimyan
Ethyl 1-amino-3,3-dimethyl-3,4-dihydronaphthalene-2-carboxylate was used as a platform to synthesize 5,5-dimethyl-3-iso-propyl-2-thioxo-2,3,5,6-tetrahydrobenzo[h]quinazolin-4(1H)-one (thioxobenzoquinazoline), which was alkylated by various halides in alkaline solution to produce 2-thio-substituted 5,5-dimethyl-3-iso-propyl-5,6-dihydrobenzo[h]quinazolin-4(3H)-ones. Condensation of thioxobenzoquinazoline
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Antimicrobial Activities of Medicinally Important Lichen Extracts Against Human Pathogenic Bacteria and Fungi Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-05
Although lichen species are a good source of bioactive compounds having medicinal importance, the biological potential of the Lichens in Kashmir region is still unexplored. The current study was designed to investigate the antimicrobial potential of various solvent extracts of 12 lichen species against pathogenic bacterial strains including Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus
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Synthesis and Antidepressant Activity of 5-Amine-Substituted 3-Bromo-1-(1,1-Dioxothietan-3-yl)-4-Nitro-1H-Pyrazoles Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-05
5-Amino-substituted 3-bromo-1-(1,1-dioxothietan-3-yl)-4-nitro-1H-pyrazoles were synthesized via the reactions of 3,5-dibromo-1-(1,1-dioxothietan-3-yl)-4-nitro-1H-pyrazole with aliphatic, aromatic, and heterocyclic amines. The structures of the synthesized compounds were confirmed by IR, PMR, and 13C NMR spectroscopy and mass spectrometry. According to in silico calculations, they were predicted to
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Mechanism of Antitumor Activity of Gold Glyconanoparticles Against Human Colon Adenocarcinoma Cells Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-04 I. V. Chernykh, M. A. Kopanitsa, A. V. Shchulkin, A. Yu. Ershov, A. A. Martynenkov, I. V. Lagoda, D. V. Kukov, E. N. Yakusheva
A possible mechanism of the antitumor activity of gold nanoparticles (GNPs) with a surface modified by carbohydrate residues tropic for tumor cell membrane lectins was studied using human colon adenocarcinoma (Caco-2) cells. Caco-2 cells were incubated for 2 and 8 h with GNP solutions. GNPs reduced the level of SH groups during a 2-hour incubation with the cells by an average of 20 times (p < 0.05);
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Biodegradable Microparticles with Encapsulated Anti-Inflammatory Peptide Ingramon Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-04 N. V. Marmiy, T. I. Arefieva, D. S. Esipov, V. N. Tashlitsky, U. S. Kozhokar, M. V. Ovchinnikov, N. V. Radyukhina, M. V. Sidorova
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Comparative Study of the Pharmacological Activity of Common Chicory Extracts Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-04 I. A. Lupanova, P. G. Mizina
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Effect of Dimethylsulfoxide on the Nociceptive Response Induced by TRPV1 Ion-Channel Stimulation in Mice Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-04 E. A. Ivanova, S. K. Mamonova, T. A. Voronina
The effect of preventive administration of a single intraperitoneal dose of dimethylsulfoxide (DMSO) at various concentrations (10, 30 and 50%; 10 mL/kg) on the nociceptive response in mice induced by local and systemic activation of TRPV1 ion channels by the TRPV1 agonist capsaicin was studied. DMSO (50%) significantly reduced (by 73.1%) the latency of the response to injection of capsaicin solution
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Synthesis and Antiproliferative Activity of 2-Oxo-4-Cyano-1,2-Dihydropyridine-3-Carboxamides Pharm. Chem. J. (IF 0.9) Pub Date : 2024-01-04 S. V. Fedoseev, K. V. Lipin
2-Oxo-4-cyano-1,2-dihydropyridine-3-carboxamides were synthesized. Their antiproliferative activity was studied. They were shown to inhibit slightly the growth of cell lines of lung cancer (a more pronounced tendency for lines A549/ATCC, NCI-H522, and HOP-62); colon cancer (more pronounced for line HCC-2998); brain cancer (for line SNB-19), melanoma (for lines UACC-62, SK-MEL-2, and MALME-3M); kidney