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Immunomodulatory Plant Natural Products as Therapeutics against Inflammatory Skin Diseases Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-15 Nikhila Sampath Kumar, Navaneetha Reddy, Halmuthur Kumar, Sravanthi Vemireddy
: Frequently occurring inflammatory skin conditions such as psoriasis, dermatitis, acne, including skin cancer, wounds and other disorders arising out of premature skin aging, deteriorate skin health and adversely impact human life. Even though several synthetic compounds have evolved for treating these skin conditions, natural-product-based therapeutics are gaining popularity with growing evidence
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Actinomycetes - The Repertoire of Diverse Bioactive Chemical Molecules: From Structures to Antibiotics Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-15 Ishfaq Ahmad Baba, Zubair Ahmad Wani, Shazia Ali, Zahoor Ahmad, Mohamad Mosa Mubarak
: The urgent need for novel antibiotics in the face of escalating global antimicrobial resistance necessitates innovative approaches to identify bioactive compounds. Actinomycetes, renowned for their prolific production of antimicrobial agents, stand as a cornerstone in this pursuit. Their diverse metabolites exhibit multifaceted bioactivities, including potent antituberculosis, anticancer, immunomodulatory
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Highlights on Fluorine-Containing Drugs Approved by U.S. FDA in 2023 Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-06 Saghir Ali, Andrew A. Bolinger, Jia Zhou
: Fluorine continues to show its potential applications in drug discovery and development, as reflected by twelve drugs being fluorinated out of the fifty-five approved by the FDA in 2023. This concise review highlights the discovery of each of these fluorine-containing drugs in the past year, including its brand name, date of approval, composition, sponsors, indication, and mechanism of action. The
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Tetrandrine for Targeting Therapy Resistance in Cancer Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-06 Ellen Nogueira Lima, Santosh Lamichhane, KC Pramod, Elisa Silva Ferreira, Hari K. Koul, Sweaty Koul
: During the last five decades, there has been tremendous development in our understanding of cancer biology and the development of new and novel therapeutics to target cancer. However, despite these advances, cancer remains the second leading cause of death across the globe. Most cancer deaths are attributed to the development of resistance to current therapies. There is an urgent and unmet need to
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Ginsenoside Rg3: A Review of its Anticancer Mechanisms and Potential Therapeutic Applications Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-05 Lei Wu, Lin Bai, Wenshu Dai, Yaping Wu, Pengjun Xi, Lily Zheng, Jie Zhang
Background:: Traditional Chinese Medicine (TCM) has a long history of treating various diseases and is increasingly being recognized as a complementary therapy for cancer. A promising natural compound extracted from the Chinese herb ginseng is ginsenoside Rg3, which has demonstrated significant anticancer effects. It has been tested in a variety of cancers and tumors and has proven to be effective
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Microfluidics-mediated Liposomal Nanoparticles for Cancer Therapy: Recent Developments on Advanced Devices and Technologies Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-01 Seyed Morteza Naghib, Kave Mohammad-Jafari
: Liposomes, spherical particles with phospholipid double layers, have been extensively studied over the years as a means of drug administration. Conventional manufacturing techniques like thin-film hydration and extrusion have limitations in controlling liposome size and distribution. Microfluidics enables superior tuning of parameters during the self-assembly of liposomes, producing uniform populations
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The Unveiling of Therapeutic Targets for Alzheimer’s Disease: An Integrative Review Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-01 Pratiksha Madar, Pooja Nagalapur, Somdatta Chaudhari, Devesh Sharma, Akshada Koparde, Rahul Buchade, Sandip Kshirsagar, Pravin Uttekar, Shailaja Jadhav, Praveen Chaudhari
: Alzheimer's disease (AD) is characterized by a complex pathological landscape, necessitating a comprehensive treatment approach. This concise review paper delves into the idea of addressing multiple mechanisms in AD, summarizing the latest research findings on pathogenesis, risk factors, diagnostics, and therapeutic strategies. The etiology of AD is multifaceted, involving genetic, environmental
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The Advancement and Obstacles in Improving the Stability of Nanocarriers for Precision Drug Delivery in the Field of Nanomedicine Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-22 Kalpesh Mahajan, Sankha Bhattacharya
Nanocarriers have emerged as a promising class of nanoscale materials in the fields of drug delivery and biomedical applications. Their unique properties, such as high surface area- tovolume ratios and enhanced permeability and retention effects, enable targeted delivery of therapeutic agents to specific tissues or cells. However, the inherent instability of nanocarriers poses significant challenges
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Recent Trends in Nanomaterial Based Electrochemical Sensors for Drug Detection: Considering Green Assessment Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-22 Tugba Ozer, Charles S. Henry
: An individual’s therapeutic drug exposure level is directly linked to corresponding clinical effects. Rapid, sensitive, inexpensive, portable and reliable devices are needed for diagnosis related to drug exposure, treatment, and prognosis of diseases. Electrochemical sensors are useful for drug monitoring due to their high sensitivity and fast response time. Also, they can be combined with portable
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Repurposing of Plant-based Antiviral Molecules for the Treatment of COVID-19 Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-22 Jabeena Khazir, Rakesh Kr Thakur, Sajad Ahmed, Manzoor Hussain, Sumit G. Gandhi, Sadhana Babbar, Shabir Ahmad Mir, Nusrat Shafi, Libert Brice Tonfack, Vijay Rani Rajpal, Tariq Maqbool, Bilal Ahmad Mir, Latif Ahmad Peer
: COVID-19, stemming from SARS-CoV-2, poses a formidable threat to global healthcare, with a staggering 77 million confirmed cases and 690,067 deaths recorded till Decem-ber 24, 2023. Given the absence of specific drugs for this viral infection, the exploration of novel antiviral compounds becomes imperative. High-throughput technologies are actively engaged in drug discovery, and there is a parallel
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A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-15 Zheng Wei, Meilun Chen, Xiaoling Lu, Yijie Liu, Guangnan Peng, Jie Yang, Chunhua Tang, Peng Yu
Peptides acquire target affinity based on the combination of residues in their sequences and the conformation formed by their flexible folding, an ability that makes them very attractive biomaterials in therapeutic, diagnostic, and assay fields. With the development of computer technology, computer-aided design and screening of affinity peptides has become a more efficient and faster method. This review
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Ciprofloxacin and Norfloxacin Hybrid Compounds: Potential Anticancer Agents Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-15 Sijongesonke Peter, Blessing A. Aderibigbe
Background:: The concept of utilizing drug repurposing/repositioning in the development of hybrid molecules is an important strategy in drug discovery. Fluoroquinolones, a class of antibiotics, have been reported to exhibit anticancer activities. Although anticancer drug development is achieving some positive outcomes, there is still a need to develop new and effective anticancer drugs. Some limitations
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The Role of Herbal Medicine in Modulating Bone Homeostasis Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-09 Xinnan Cheng, Shanshan Jin, Mingzhe Feng, Yunfeng Miao, Baorong He, Qi Dong
: Osteoporosis and other bone diseases are a major public health concern worldwide. Current pharmaceutical treatments for bone disorders have limitations, driving interest in complementary herbal medicines that can help maintain bone health. This review summarizes the scientific evidence for medicinal herbs that modulate bone cell activity and improve bone mass, quality and strength. Herbs with osteogenic
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Nitrosamines, ICH Q3A-Q3E, Global Substance Registration System (GSRS), N-nitroso dimethyl amine (NDMA), Drug substance life cycle. Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-07 Darshan Bhirud, Gyan Agrawal, Harshil Shah, Artiben Patel, Mahesh B. Palkar, Sankha Bhattacharya, Bhupendra G. Prajapati
: Since their discovery in valsartan-containing drugs, nitrosamine impurities have emerged as a significant safety problem in pharmaceutical products, prompting extensive recalls and suspensions. Valsartan, candesartan, irbesartan, olmesartan, and other sartans have been discovered to have additional nitrosamine impurities, such as N-nitroso-N-methyl-4-aminobutyric acid (NMBA), N-nitroso-Di-isopropyl
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Valeriana jatamansi: Bioactive Compounds and their Medicinal Uses Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-06 Antim K. Maurya, Vijai K. Agnihotri
: Valeriana jatamansi is a reputed perennial medicinal herb distributed throughout the world, where it is used in cytotoxicity, neuronal problems, insomnia, leishmania and acetylcho-linesterase inhibitor, antioxidant, antiviral and α-glucosidase inhibition activities. This review de-scribes the current state of chemical characterization of isolated metabolites, which are well ac-cepted for the treatment
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Pyrazoline Derivatives as Promising MAO-A Targeting Antidepressants: An Update Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-02 Diksha Choudhary, Rajwinder Kaur, Thakur Gurjeet Singh, Bhupinder Kumar
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Combating COVID-19 Crisis using Artificial Intelligence (AI) Based Approach: Systematic Review Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-02 Kavya Singh, Navjeet Kaur, Ashish Prabhu
Background: SARS-CoV-2, the unique coronavirus that causes COVID-19, has wreaked damage around the globe, with victims displaying a wide range of difficulties that have encouraged medical professionals to look for innovative technical solutions and therapeutic approaches. Artificial intelligence-based methods have contributed a significant part in tackling complicated issues, and some institutions
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Molecular Biomarkers in Cholangiocarcinoma: Focus on Bile Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-31 Andrey D. Dolbnya, Igor A. Popov, Stanislav I. Pekov
Hepatobiliary system cancers have demonstrated an increasing incidence rate in the past years. Without the presence of early symptoms, the majority of such cancers manifest with a set of similar symptoms, such as cholestasis resulting in posthepatic icterus. Differential diagnosis of hepatobiliary cancers is required for the therapy selection, however, the similarity of the symptoms complicates diagnostics
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Recent Developments and Future Perspectives of Purine Derivatives as a Promising Scaffold in Drug Discovery Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Neha Rana, Parul Grover, Hridayanand Singh
: Numerous purine-containing compounds have undergone extensive investigation for their medical efficacy across various diseases. The swift progress in purine-based medicinal chemistry has brought to light the therapeutic capabilities of purine-derived compounds in addressing challenging medical conditions. Defined by a heterocyclic ring comprising a pyrimidine ring linked with an imidazole ring, purine
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An Update on Pharmacological and Phytochemical Aspects of Costus pictus D. Don - A Promising Anti-diabetic Plant Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Vipin Kumar Singh, Kuldeep Singh Yadav, Shiny C. Thomas, Ambika Gupta, Suaib Luqman, Karuna Shanker, Umesh Kumar Patil, Narayan Prasad Yadav
Background: The genus Costus is the largest genus in the family Costaceae and encompasses about 150 known species. Among these, Costus pictus D. Don (Synonym: Costus mexicanus) is a traditional medicinal herb used to treat diabetes and other ailments. Currently, available treatment options in modern medicine have several adverse effects. Herbal medicines are gaining importance as they are cost-effective
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The Mushroom Albatrellus confluens: A Minireview on Phytochemistry, Biosynthesis, Synthesis and Pharmacological Activities Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Ninh The Son, Chu Anh Van
Background: Albatrellus confluens is one of the representative species in the Polyporaceae family. Its major mero terpenoid grifolin and related compounds have the potential for drug applications. Objective: The current study aims to briefly provide an insightful view of the phytochemistry, biosynthesis, synthesis, and pharmacology of A. confluens metabolites Methods: Data collection was performed
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Targeted Cancer Stem Cell Therapeutics: An Update Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Naurin Fatima, Mohammad Umar, Subiya Ambreen, Mohd Shaququzzaman, Mohammad Mumtaz Alam, Ruhi Ali
: Cancer stem cells (CSCs) have become a key player in the growth of tumors, the spread of cancer, and the resistance to therapeutic interventions. Targeting these elusive cell populations has the potential to fundamentally alter cancer treatment plans. CSCs, also known as tumor-initiating cells (TICs), are thought to play a role in both medication resistance and cancer recurrence. This is explained
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Deciphering Tuberculous Meningitis: From Clinical Challenges to Novel Models and Pathogenic Pathways Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Mohamad Mosa Mubarak, Shahnawaz Majeed, Hadiya Amin Kantroo, Zubair Ahmad Wani, Abbass Malik, Zahoor Ahmad, Ishfaq Ahmad Baba
: During and after the COVID-19 pandemic,Tuberculosis (TB) has reestablished with higher figures due to interruptions in the Directly Observed Treatment Short course (DOTS) despite underreporting. The rising consequences would have extended to extra-pulmonary forms of TB as well, including Tuberculous Meningitis (TBM). Considering the fact that TBM is the most dangerous and worst form of TB, we found
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Tackling Nontuberculous Mycobacteria by Repurposable Drugs and Potential Leads from Natural Products Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Patil Amruta Adhikrao, Gudle Mayuri Motiram, Gautam Kumar
: Nontuberculous Mycobacteria (NTM) refer to bacteria other than all Mycobacterium species that do not cause tuberculosis or leprosy, excluding the species of the Mycobacterium tu-berculosis complex, M. leprae and M. lepromatosis. NTM are ubiquitous and present in soils and natural waters. NTM can survive in a wide range of environmental conditions. The direct inocu-lum of the NTM from water or other
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Anti-COVID-19 Potential of Withaferin-A and Caffeic Acid Phenethyl Ester Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-27 Vipul Kumar, Anissa Nofita Sari, Dharmender Gupta, Yoshiyuki Ishida, Keiji Terao, Sunil C. Kaul, Sudhanshu Vrati, Durai Sundar, Renu Wadhwa
Background: The recent COVID-19 (coronavirus disease 2019) pandemic triggered research on the development of new vaccines/drugs, repurposing of clinically approved drugs, and assessment of natural anti-COVID-19 compounds. Based on the gender difference in the severity of the disease, such as a higher number of men hospitalized and in intense care units, variations in sex hormones have been predicted
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Phytotherapeutics in Cancer: From Potential Drug Candidates to Clinical Translation Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-26 Parul Grover, Kulbhushan Thakur, Monika Bhardwaj, Lovekesh Mehta, Soom Nath Raina, Vijay Rani Rajpal
: Annually, a significant number of individuals succumb to cancer, an anomalous cellular condition characterized by uncontrolled cellular proliferation and the emergence of highly perilous tumors. Identifying underlying molecular mechanism(s) driving disease progression has led to various inventive therapeutic approaches, many of which are presently under pre-clinical and/or clinical trials. Over the
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P-coumaric Acid: Advances in Pharmacological Research Based on Oxidative Stress Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-25 Feixiang Chen, Xinxin Zhang, Junxiang Wang, Fukai Wang, Jinlong Mao
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Neurobiochemical Disturbances in Psychosis and their Implications for Therapeutic Intervention Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-24 Georgi Panov, Presyana Panova
: Psychosis, marked by the emergence of psychotic symptoms, delves into the intricate dance of neurotransmitter dynamics, prominently featuring dopamine as a key orchestrator. In individuals living with psychotic conditions, the finely tuned balance of dopamine becomes disrupted, setting off a cascade of perceptual distortions and the manifestation of psychotic symptoms. A lot of factors can impact
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The Role of Cytokines in Activation of Tumour-promoting Pathways and Emergence of Cancer Drug Resistance Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-23 Ekta Shirbhate, Vaibhav Singh, Rakesh Kore, Subham Vishwakarma, Ravichandran Veerasamy, Amit K. Tiwari, Harish Rajak
: Scientists are constantly researching and launching potential chemotherapeutic agents as an irreplaceable weapon to fight the battle against cancer. Despite remarkable advancement over the past several decades to wipe out cancer through early diagnosis, proper prevention, and timely treatment, cancer is not ready to give up and leave the battleground. It continuously tries to find some other way
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The Neurobiology of Formal Thought Disorder Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-21 Erik Dornelles, Diogo Telles Correia
: The concept of Formal Thought Disorder (FTD) is an ambiguous and disputed one, even though it has endured as a core psychopathological construct in clinical Psychiatry. FTD can be summarized as a multidimensional construct, reflecting difficulties or idiosyncrasies in thinking, language, and communication in general and is usually subdivided into positive versus negative. In this article, we aim
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Recent Advances in Metallic Nanostructures-Assisted Biosensors for Medical Diagnosis and Therapy Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-21 Ecem Tiryaki, Tolga Zorlu
: The field of nanotechnology has witnessed remarkable progress in recent years, particularly in its application to medical diagnosis and therapy. Metallic nanostructures-assisted biosensors have emerged as a powerful and versatile platform, offering unprecedented opportunities for sensitive, specific, and minimally invasive diagnostic techniques, as well as innovative therapeutic interventions. These
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Unlocking the Pharmacological Potential of Benzimidazole Derivatives: A Pathway to Drug Development Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-19 Jyoti Monga, Niladry S. Ghosh, Isha Rani, Ranjit Singh, Geeta Deswal, Ashwani K. Dhingra, Ajmer S. Grewal
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Stimuli-induced NOergic Molecules and Neuropeptides Mediated Axon Reflexes Contribute to Tracers along Meridian Pathways Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-18 Shengxing Ma
An abundance of studies from different international groups have demonstrated tracers along linear pathways resembling meridians over the body surface of humans. All experiments of the studies have been conducted by injection of a radiotracer solution or tracer dyes in a volume of solution into acupuncture points (acupoints). The solution injected into acupoints produces much stronger mechanical stimuli
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Current Status of Hedgehog Signaling Inhibitors Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-17 Xiaotang Wang, Tian Wang, Xiaona Song, Jiping Gao, Guoqiang Xu, Yunhui Ma, Guohua Song
: The Hedgehog (Hh) signaling pathway plays a crucial role in diverse biological pro-cesses such as cell differentiation, proliferation, senescence, tumorigenesis, malignant transfor-mation, and drug resistance. Aberrant Hh signaling, resulting from mutations and excessive acti-vation, can contribute to the development of various diseases during different stages of biogenesis and development. Moreover
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Pharmacological Effects of FTY720 and its Derivatives Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-05 Mengyuan Han, Xiangran Liu, Sendaer Hailati, Nulibiya Maihemuti, Nurbiya Nurahmat, Dilihuma Dilimulati, Alhar baishan, Alifeiye Aikebaier, Wenting Zhou, Yan Pan
FTY720 is an analog of sphingosine-1-phosphate (S1P) derived from the ascomycete Cordyceps sinensis. As a new immunosuppressant, FTY720 is widely used to treat multiple sclerosis. FTY720 binds to the S1P receptor after phosphorylation, thereby exerting immunosuppressive effects. The nonphosphorylated form of FTY720 can induce cell apoptosis, enhance chemotherapy sensitivity, and inhibit tumor metastasis
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Role of Ubiquitin-specific Proteases in Hepatocellular Carcinoma Pathogenesis Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-03 Xinwen Zhang, Jiamin Jin, Jiacheng Cong, Siqi Chen, Ting Wang, Bin Gao, Guanlin Huang, Zhiqiang Huang, Juzheng Zhang, Zhenran Wang, Jinfeng Yang
Signaling pathways in hepatocellular carcinoma are primarily mediated by the phosphorylation and ubiquitination of post-translational proteins. In mammalian cells, ubiquitin-specific proteases (USPs) account for the majority of protein deubiquitination activities. In addition to transcriptional and post-translational regulation, ubiquitination plays an important role in the regulation of key proteins
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Sesamol: A Phenolic Compound of Health Benefits and Therapeutic Promise in Neurodegenerative Diseases Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-12-23 Hayate Javed, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha, Ghulam Md Ashraf, Shreesh Ojha
: Sesamol, one of the key bioactive ingredients of sesame seeds (sesamum indicum L.), is responsible for many of its possible nutritional benefits. Both the Chinese and Indian medical systems have recognized the therapeutic potential of sesame seeds. It has been shown to have significant therapeutic potential against oxidative stress, inflammatory diseases, metabolic syndrome, neurodegeneration, and
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Cordia Dichotoma: A Comprehensive Review of its Phytoconstituents and Endophytic Fungal Metabolites and their Potential Anticancer Effects Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-12-20 Saurav Madhavrao Patil, Sankha Bhattacharya
Cordia dichotoma is a valuable medicinal plant belonging to the family Boraginaceae. It consists of several beneficial secondary metabolite components, including alkaloids, carbohydrates, flavonoids, glycosides, saponins, and tannins. Numerous studies have been conducted to assess the anticancer properties of Cordia dichotoma on MCF-7, A-549, PC3, and HeLa cancer cell lines, primarily utilizing ethanolic
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Improving ADMET Prediction Accuracy for Candidate Drugs: Factors to Consider in QSPR Modeling Approaches Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-12-11 Meilun Chen, Jie Yang, Chunhua Tang, Xiaoling Lu, Zheng Wei, Yijie Liu, Peng Yu, HuanHuan Li
Quantitative Structure-Property Relationship (QSPR) employs mathematical and statistical methods to reveal quantitative correlations between the pharmacokinetics of compounds and their molecular structures, as well as their physical and chemical properties. QSPR models have been widely applied in the prediction of drug absorption, distribution, metabolism, excretion, and toxicity (ADMET). However,
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Discovery of Tropomyosin Receptor Kinase Inhibitors as New Generation Anticancer Agents: A Review Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-12-07 Ishan Panchal, Rati Tripathi, Kinjal Parmar, M R Yadav
Background:: The tropomyosin receptor kinases (TRKs) are crucial for many cellular functions, such as growth, motility, differentiation, and metabolism. Abnormal TRK signalling contributes to a variety of human disorders, most evidently cancer. Comprehensive genomic stud-ies have found numerous changes in the genes that code for TRKs like MET, HER2/ErbB2, and EGFR, among many others. Precision medicine
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To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting Inhibitors Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-12-04 Debroop Basu, Riya Pal, Maitrayee Sarkar, Soubhik Barma, Sumit Halder, Harekrishna Roy, Sisir Nandi, Asmita Samadder
: Receptor tyrosine kinase (RTK) regulates multiple pathways, including Mitogen-activated protein kinases (MAPKs), PI3/AKT, JAK/STAT pathway, etc. which has a significant role in the progression and metastasis of tumor. As RTK activation regulates numerous essential bodily processes, including cell proliferation and division, RTK dysregulation has been identified in many types of cancers. Targeting
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Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and Applications Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-11-30 Lokesh Chandrakar, Ramesh Ambatwar, Gopal L. Khatik
Cellular senescence, an eternal condition of cell cycle arrest due to cellular stressors, is a sign of aging. Senescent cells (SCs) build up in tissues as they age, impairing their ability to repair themselves by causing the cell cycle to seize in progenitor cells and producing proinflammatory and the senescence-associated secretory phenotype (SASP) or matrix-degrading molecules. SASP aids in the emergence
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Recent Trends in Computer-aided Drug Design for Anti-cancer Drug Discovery Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-11-30 Iashia Tur Razia, Ayesha Kanwal, Hafiza Fatima Riaz, Abbeha Malik, Muhammad Ahsan, Muhammad Saleem Khan, Ali Raza, Sumera Sabir, Zureesha Sajid, Muhammad Fardeen Khan, Rana Adnan Tahir, Sheikh Arslan Sehgal
: Cancer is considered one of the deadliest diseases globally, and continuous research is being carried out to find novel potential therapies for myriad cancer types that affect the human body. Researchers are hunting for innovative remedies to minimize the toxic effects of conventional therapies being driven by cancer, which is emerging as pivotal causes of mortality worldwide. Cancer progression
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QSAR Studies of Nitric Oxide Synthase Inhibitors Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-11-29 Ioanna-Chrysoula Tsopka, Dimitra Hadjipavlou-Litina
Background:: Nitric oxide is a free radical bioregulator controlling homeostasis, vasodilation, and inhibition of platelet aggregation, significantly implicated in the nervous and immune system functionality. In vivo it is produced by nitric oxide synthases (NOSs). Objective:: Overproduction of nitric oxide is linked to several inflammatory, immunological, and neurodegenerative diseases and for that
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Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-11-27 Shahnaz Parveen, Nidhi Maurya, Abha Meena, Suaib Luqman
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Enhancing Opiorphin’s Metabolic Stability and Preserving its Potent Analgesic Effect: A Systematic Review Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-11-07 Joana Tome, Mohammed Nurudeen Ibrahim, Logan T. Cowan
Background: stronger analgesic effect than morphine without causing side effects brought about by morphine-like drugs. Functional opiorphin analogs have been created to enhance its metabolic stability and preserve its potent analgesic effect. Objective: We conducted a systematic review to summarize all opiorphin analogs and identify those with the strongest metabolic stability and antinociceptive effect
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Protein Dynamics Mediated by Cardiolipin in Bacteria Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-11-06 Yanyang Wang, Jiawen Chen, Liyang Hang, Jichao Zhu, Xinhua Qiang, Mingjian Yang, Xiangliang Sun, Sha Wang, Hongchang Zhou, Yibin Lin, Shengwen Shao
: Bacterial proteins targeting the appropriate subcellular sites are the base for their proper function. Several studies have shown that the anionic phospholipid cardiolipin (CL), a conical lipid preferring negative membrane curvature, modulates the lipid bilayers’ structure, which impacts the activity of their resident proteins. Due to the favor of negative membrane curvature, CL is not randomly distributed
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Natural Plant Products Mediated Prevention of Cancer Facilitated through Immune Suppression of Treg Cells Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-11-03 Oishi Mukherjee, Sudeshna Rakshit, Geetha Shanmugan, Koustav Sarkar
Cancer is one of the leading causes of death, and numerous methods have been tested and used to figure out an optimum way of treatment. Besides targeted therapy, immunotherapy has proven to be effective by controlling certain immune cells. Traditional cancer therapy is met with the consequences of adverse side effects that have been a major issue for treatment; hence, a leap towards naturally occurring
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A Comprehensive Review on Phytochemistry and Pharmacology of Rosa Species (Rosaceae) Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-11-01 Faheem Fayaz, Kanwaljeet Singh, Sumeet Gairola, Zabeer Ahmed, Bhahwal Ali Shah
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n-3 PUFAs Show Promise as Adjuvants in Chemotherapy, Enhancing their Efficacy while Safeguarding Hematopoiesis and Promoting Bone Generation Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-11-01 Pradnya Gurav, Suraj Garad, Kedar R.N.
: Cancer ranks as the second leading cause of mortality in high-income countries, underscoring the critical need for effective therapeutic strategies. One prominent approach, chemotherapy, is widely employed for treating solid tumors. However, the significant adverse effects associated with chemotherapy, notably myeloablation and osteonecrosis, impart considerable challenges by compromising immune
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Recent Development in the Search for Epidermal Growth Factor Receptor (EGFR) Inhibitors based on the Indole Pharmacophore Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-11-01 Shweta Mishra, Adarsh Sahu, Avneet Kaur, Maninder kaur, Jayendra kumar, Pranay Wal
: The signal transduction and cell proliferation are regulated by the epidermal growth factor receptor. The proliferation of tumor cells, apoptosis, invasion, and angiogenesis is inhibited by the epidermal growth factor receptor. Thus, breast cancer, non-small cell lung cancer, cervical cancer, glioma, and bladder cancer can be treated by targeting the epidermal growth factor receptor. Although third-generation
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Phytochemicals Showing Antiangiogenic Effect in Pre-clinical Models and their Potential as an Alternative to Existing Therapeutics Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-10-20 Anna Senrung, Tanya Tripathi, Nikita Aggarwal, Divya Janjua, Joni Yadav, Apoorva Chaudhary, Arun Chhokar, Udit Joshi, Alok Chandra Bharti
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Quantitative Structure Activity/Toxicity Relationship through Neural Networks for Drug Discovery or Regulatory Use Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-10-20 Marjana Novič
Quantitative structure - activity relationship (QSAR) modelling is widely used in medicinal chemistry and regulatory decision making. The large amounts of data collected in recent years in materials and life sciences projects provide a solid foundation for data-driven modelling approaches that have fostered the development of machine learning and artificial intelligence tools. An overview and discussion
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Review the Role of Metabolism Reprogramming in the Pathogenesis of Post-surgical Adhesion: A New Therapeutic Strategy Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-10-20 Mohsen Aliakbarian, Rozita Khodashahi, Mahmoud Tavakkoli, Kiarash Ashrafzadeh, Hoda Rahimi, Ebrahim Khaleghi, Majid Ghayour-Mobarhan, Mohammad-Hassan Arjmand
Metabolic reprogramming is defined as the skill of cells to change their metabolism to support the induced energy demand due to continuous growth. Metabolic reprogramming is a well- known occurrence in the progression of neoplastic cells, although, evidence has shown that it is present in fibrotic disorders. Post-surgical adhesion as a fibrotic disorder is a medical challenge and is defined by fibrotic
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Antiviral Effects and Mechanisms of Green Tea Catechins on Influenza: A Perception on Combating Symptoms from COVID-19 Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-10-19 Gene Chi Wai Man, Xu Zheng, Sze Wan Hung, Loucia Kit Ying Chan, Tao Zhang, Xiaoyan Chen, Kai On Chu, Ian Chung Yuen Huen, Darren Wang Yip Lui, Alfred Ding Wong, Chi Chiu Wang
: Over the centuries, influenza and its associated epidemics have been a serious public health problem. Although vaccination and medications (such as neuraminidase inhibitors) are the mainstay of pharmacological approaches to prevent and treat influenza, however, frequent mutations in the influenza genome often result in treatment failure and resistance to standard medications which limit their effectiveness
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Targeting Various Pathogenic Pathways for the Development of Antialzheimer’s Drugs: An Update Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-10-15 Subiya Ambreen, Naurin Fatima, Mohammad Umar, Mohd Shaququzzaman, Mohammad Mumtaz Alam, Ruhi Ali
: Alzheimer’s disease (AD) has been recognized as the most important cause of dementia, which is estimated to contribute more than 2 trillion USD in medical costs. AD patients encounter progressive neurodegenerative dementia associated with behavioural, linguistic, and visuospatial deficits. Although studies on the discovery of amyloid β (Aβ) and tau (the essential elements of plaques and tangles in
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Significant Advancement in Various Synthetic Strategies and Pharmacotherapy of Piperine Derivatives: A Review Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-10-11 Sagar Joshi, Salahuddin, Avijit Mazumder, Rajnish Kumar, Km Shabana, Sonakshi Tyagi, Kavita Rana, Mohamed Jawed Ahsan, Mohammad Shahar Yar, Arvind Arya, Navneet Khurana
Background: Piperine is a natural compound found in black pepper that has been traditionally used for various therapeutic purposes. In the ayurvedic system of medication there is a lot of evidence which shows that the piperine is widely used for different therapeutic purpose. In recent years, there has been an increasing interest in the pharmacological and therapeutic potential of piperine and its
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Finding Integrative Medication for Neuroblastoma and Glioblastoma through Zebrafish as A Model of Organism Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-10-11 Mohammad Barati, Amir Modarresi Chahardehi, Yasaman Hosseini
As far as malignant tumors of the central nervous system are concerned, glioblastoma (GB) and neuroblastoma (NB) are the most prevalent, aggressive, and fatal forms in adult and pediatric populations, respectively. NB is the most prominent childhood extracranial compact neoplasm in pediatrics when the embryo develops from undifferentiated neural crest cells. Regarding malignant primary brain tumors
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An Updated Overview of Synthetic α-glucosidase Inhibitors: Chemistry and Bioactivities Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-10-11 Yong-Si Cai, Hong-Xu Xie, Jin-He Zhang, Yue Li, Juan Zhang, Kai-Ming Wang, Cheng-Shi Jiang
: Diabetes mellitus (DM) is a critical global health issue, affecting nearly half a billion people worldwide, with an increasing incidence rate and mortality. Type 2 diabetes is caused by the body's inability to effectively use insulin, and approximately 95% of patients have type 2 diabetes. α-glucosidase has emerged as an important therapeutic target for the treatment of type 2 diabetes. In the past
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Exploring the Potential of Natural Products as Antiparasitic Agents for Neglected Tropical Diseases Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2023-10-10 Dayanna Orosco, Arturo René Mendoza, Carlos Mario Meléndez
Recent developments in the use of natural product-based molecules as antiparasitic agents for Malaria, leishmaniasis (LE), Chagas disease (CD), and Human African trypanosomiasis (HAT) are reviewed. The role of diverse plants in developing bioactive species is discussed in addition to analyzing the structural diversity of natural products as active agents and the diverse biological applications in CD