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Evidences of G-Coupled Protein Receptor (GPCR) signaling in the human malaria parasite Plasmodium falciparum for sensing its microenvironment and the role of purinergic signaling in malaria parasites.. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Pedro H S Pereira,Lucas Borges-Pereira,Célia R S Garcia
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The Role of Purinergic Signaling in Trichomonas vaginalis Infection. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Micheli Ferla,Tiana Tasca
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Unveiling the potential of purinergic signaling in schistosomiasis treatment. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Nathália Ferreira Oliveira,Claudia Lucia Martins Silva
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The Complexity of Purinergic Signaling During Toxoplasma Infection Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Aline Cristina Abreu Moreira-Souza and Robson Coutinho-Silva
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ENTPDases from Pathogenic Trypanosomatids and Purinergic Signaling: Shedding Light towards Biotechnological Applications Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Walmir da Silva, Nancy da Rocha Torres, Joice de Melo Agripino, Victor Hugo Ferraz da Silva, Anna Cláudia Alves de Souza, Isadora Cunha Ribeiro, Tatiana Aparecida de Oliveira, Luciana Angelo de Souza, Lethicia Kelly Ramos Andrade, João Victor Badaró de Moraes, Marcel Arruda Diogo, Raíssa Barbosa de Castro, Marcelo Depolo Polêto, Luis Carlos Crocco Afonso and Juliana Lopes Rangel Fietto
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GPRASP/ARMCX Protein Family: Potential Involvement in Health and Diseases Revealed by their Novel Interacting Partners Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Juliette Kaeffer, Gabrielle Zeder-Lutz, Frédéric Simonin and Sandra Lecat
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Computational and Experimental Approaches to Investigate Lipid Nanoparticles as Drug and Gene Delivery Systems Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Chun Chan, Shi Du, Yizhou Dong and Xiaolin Cheng
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Nanoscale Drug Delivery Systems for Glaucoma: Experimental and In Silico Advances. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Smriti Sharma,Vinayak Bhatia
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Hyaluronan based Multifunctional Nano-carriers for Combination Cancer Therapy. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Menghan Gao,Hong Deng,Weiqi Zhang
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Solubility Enhancement of Methotrexate by Solid Nanodispersion Approach for the Improved Treatment of Small cell Lung Carcinoma. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Karthikeyan Rajalingam,Venkateshwaran Krishnaswami,Shanmugarathinam Alagarsamy,Ruckmani Kandasamy
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The Pathogenesis Mechanism, Structure Properties, Potential Drugs and Therapeutic Nano-particles Against the Small Oligomers of Amyloid-β. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-12-31 Ke Wang,Liu Na,Mojie Duan
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Natriuretic Peptides as the Basis of Peptide Drug Discovery for Cardiovascular Diseases Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-11-30 Yana Lerner, Wessal Hanout, Shulamit Fluss Ben-Uliel, Samar Gani, Michal (Pellach) Leshem and Nir Qvit
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Current Approaches in Diabetes Treatment and Other Strategies to Reach Normoglycemia. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-11-30 Worood Sirhan,Ron Piran
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Peptide Shuttle-Mediated Delivery for Brain Gene Therapies Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-11-30 Josep Garcia, Pol Arranz-Gibert, Macarena Sánchez-Navarro, Ernest Giralt and Meritxell Teixidó
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Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-11-30 Danny Feijtel,Marion de Jong,Julie Nonnekens
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Engineering “Antimicrobial Peptides” and Other Peptides to Modulate Protein-Protein Interactions in Cancer Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-11-30 Samuel J.S. Rubin and Nir Qvit
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Spotlight on the Selected New Antimicrobial Innate Immune Peptides Discovered During 2015-2019 Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-11-30 Xiangli Dang and Guangshun Wang
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Characterization of P. aeruginosa Glucose 6- Phosphate Isomerase: A Functional Insight via In-Vitro Activity Study. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-10-31 Deekshi Angira,Nalini Natarajan,Samir R Dedania,Darshan H Patel,Vijay Thiruvenkatam
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Exploring the Potential Inhibition of Candidate Drug Molecules for Clinical Investigation based on their Docking or Crystallographic Analyses against M. tuberculosis Enzyme Targets. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-10-31 Rishita Dey,Sisir Nandi,Asmita Samadder,Aaruni Saxena,Anil Kumar Saxena
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Substituted 6,7-dimethoxy-5-oxo-2,3,5,9b-tetrahydrothiazolo[2,3-a]isoindole-3-1,1-dioxidederivatives with antimicrobial activity and docking assisted prediction of the mechanism of their antibacterial and antifungal properties. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-10-31 Athina Geronikaki,Victor Kartsev,Phaedra Eleftheriou,Anthi Petrou,Jasmina Glamočlija,Anna Ciric,Marina Soković
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Potential Inhibitors of Protein Tyrosine Phosphatase (PTP1B) Enzyme: Promising Target for Type-II Diabetes Mellitus. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-10-31 Sisir Nandi,Mridula Saxena
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The Endeavours in RAS Inhibition - the Past, Present, and Future. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-10-31 Javeena Hussain,Sivapriya Kirubakaran,Srimadhavi Ravi
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ATP Synthase Inhibitors as Anti-tubercular Agents: QSAR Studies in Novel Substituted Quinolines. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-10-31 Anil K Saxena,Muneer Alam
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Multifunctional nanoparticles in precise cancer treatment: considerations in design and functionalization of nanocarriers. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 Lina Lu,Shuhe Kang,Chao Sun,Chufeng Sun,Zhong Guo,Jia Li,Taofeng Zhang,Xingping Luo,Bin Liu
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Nanotechnology assisted chemotherapy for targeted cancer treatment: recent advances and clinical perspectives. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 Huan-Rong Lan,Zhi-Qiang Wu,Li-Hua Zhang,Ke-Tao Jin,Shi-Bing Wang
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Matrix metalloproteinases (MMPs) in targeted drug delivery: Synthesis of a Potent and Highly Selective Inhibitor against Matrix metalloproteinases-7. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 Ling-Li Wang,Bing Zhang,Ming-Hua Zheng,Yu-Zhong Xie,Chang-Jiang Wang,Jing-Yi Jin
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Membrane derived Vesicles as Biomimetic Carriers for Targeted Drug Delivery system. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 Le-Yi Zhang,Xue Yang,Shi-Bing Wang,Hong Chen,Hong-Ying Pan,Zhi-Ming Hu
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Glycyrrhetinic acid and TAT peptide modified dual-functional liposomes for treatment of hepatocellular cancer. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 Sixi Huang,Di Ren,Xinrong Wu,Ming Li,Xuesong Yu,Xiaoling Nie,Ying Wang,Yan Wang
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Quantitative structure-activity relationships studying the toxicity of metal nanoparticles. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 Yuting Gao,Honglin Zhai,Xilin She,Hongzong Si
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Small molecule regulation of stem cells that generate bone, chondrocyte, and cardiac cells. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 John R Cashman
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Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 Satya P Gupta
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Emerging Proof of Protein Misfolding and Interaction in Multifactorial Alzheimer's Disease. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 Md Sahab Uddin,Abdullah Al Mamun,Md Ataur Rahman,Tapan Behl,Asma Perveen,Abdul Hafeez,May N Bin-Jumah,Mohamed M Abdel-Daim,Ghulam Md Ashraf
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Exploring Multiple Sclerosis (MS) and Amyotrophic Lateral Scler osis (ALS) as Neurodegenerative Diseases and their Treatments: A Review Study Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 Omar Deeb and Maisa Nabulsi
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Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-30 Mayasah Y Al-Nema,Anand Gaurav
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Ligand- and structure-based virtual screening of Lamiaceae diterpenes with potential activity against a novel coronavirus (2019-nCoV). Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Gabriela Cristina Soares Rodrigues,Mayara Dos Santos Maia,Renata Priscila Barros de Menezes,Andreza Barbosa Silva Cavalcanti,Natália Ferreira de Sousa,Érika Paiva de Moura,Alex France Messias Monteiro,Luciana Scotti,Marcus Tullius Scotti
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Shape-based Machine Learning Models for the potential Novel COVID-19 protease inhibitors assisted by Molecular Dynamics Simulation. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Ravina Khandelwal,Anuraj Nayarisseri,Maddala Madhavi,Chandrabose Selvaraj,Umesh Panwar,Khushboo Sharma,Tajamul Hussain,Sanjeev Kumar Singh
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An Update on Staphylococcus aureus NorA Efflux Pump Inhibitors. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Kadja Luana Chagas Monteiro,Thiago Mendonça de Aquino,Francisco Jaime B Mendonça Junior
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Biological evaluation of selected 1,2,3-triazole derivatives as antibacterial and antibiofilm agent. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Lialyz Soares Pereira André,Renata Freire Alves Pereira,Felipe Ramos Pinheiro,Aislan Cristina Rheder Fagundes Pascoal,Vitor Francisco Ferreira,Fernando de Carvalho da Silva,Daniel Tadeu Gomes Gonzaga,Dora Cristina Silva Costa,Tainara Ribeiro,Daniela Sachs,Fábio Aguiar-Alves
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Synthesis, evaluation of antimicrobial activity and molecular docking of new N-1,3-thiazol-2-ylacetamides of condensed pyrido[3',2':4,5]furo(thieno)[3,2-d]pyrimidines. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Sirakanyan S N,Kartsev V G,Geronikaki A,Spinelli D,Petrou A,Hakobyan E K,Glamoclija Ja,Ivanov M,Sokovic M,Hovakimyan A A
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Therapeutic targets and computational approaches on drug development for COVID-19. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Anusuya Shanmugam,Nisha Muralidharan,D Velmurugan,M Michael Gromiha
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Identification and characterization of Lipopeptide Biosurfactant producing Microbacterium sp isolated from brackish river water. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Anuraj Nayarisseri,Ravina Khandelwal,Sanjeev Kumar Singh
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1,2,4-Triazole A Privileged Scaffold For The Development Of Potent Antifungal Agents-A Brief Review. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Christophe Tratrat
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Evidence Linking Protein Misfolding to Quality Control in Progressive Neurodegenerative Diseases. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Md Tanvir Kabir,Md Sahab Uddin,Ahmed Abdeen,Ghulam Md Ashraf,Asma Perveen,Abdul Hafeez,May N Bin-Jumah,Mohamed M Abdel-Daim
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Rosmarinic Acid as a Potent Influenza Neuraminidase Inhibitor: In Vitro and In Silico Study Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Panupong Mahalapbutr,Mattanun Sangkhawasi,Jirayu Kammarabutr,Supakarn Chamni,Thanyada Rungrotmongkol
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Insight Into Mechanism of Action of Anticancer Benzazoles. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Ozum Ozturk,Esin Aki-Yalcin,Ismail Yalcin,Renate Grifitth
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Synthesis and Characterization of Quinoline-3-Carboxamide Derivatives as Inhibitors of the ATM Kinase. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Srimadhavi Ravi,Sugata Barui,Sivapriya Kirubakaran,Parul Duhan,Kaushik Bhowmik
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An insight of scientific developments in TSC for better therapeutic strategy. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Nalini Natarajan,Vijay Thiruvenkatam
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N-[3,5-Bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide Analogues: Novel Acetyl- and Butyrylcholinesterase Inhibitors. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Martin Krátký,Karolína Jaklová,Šárka Štěpánková,Katarína Svrčková,Václav Pflégr,Jarmila Vinšová
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Novel Iodinated Hydrazide-hydrazones and their Analogues as Acetyl- and Butyrylcholinesterase Inhibitors. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Martin Krátký,Šárka Štěpánková,Michaela Brablíková,Katarína Svrčková,Markéta Švarcová,Jarmila Vinšová
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Current Challenges and Implications of Proteogenomic Approaches in Prostate Cancer. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Nidhi Shukla,Narmadhaa Siva,Babita Malik,Prashanth Suravajhala
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Cedrus deodara (bark) essential oil induces apoptosis in human colon cancer cells by inhibiting Nuclear Factor kappa B. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Madhulika Bhagat,Ajay Kumar,Renuka Suravajhala
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Selective targeted drug delivery mechanism via molecular imprinted polymers in cancer therapeutics. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Renuka Suravajhala,Harshavardhan Reddy Burri,Babita Malik
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Nanophytomedicine Based Novel Therapeutic Strategies in Liver Cancer Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Sachin Kumar,Faizana Fayaz,Faheem Hyder Pottoo,Sakshi Bajaj,Satish Manchanda,Himangini Bansal
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Discovery and Development of Inflammatory Inhibitors From 2-Phenylchromonone (Flavone) Scaffolds. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-24 Chen Xu,Meng-Yuan Fang,Ke Wang,Jing Liu,Guang-Ping Tai,Zhao-Ting Zhang,Ban-Feng Ruan
Flavonoids are compounds based on the 2-phenylchromonone scaffold. Flavonoids can be divided into flavonoids, flavonols, dihydroflavones, anthocyanins, chalcones and diflavones according to the oxidation degree of the central tricarbonyl chain, the connection position of B-ring (2-or 3-position) and whether the tricarbonyl chain forms a ring or not. There are a variety of biological activities about
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Synthesis and biological activity study of tanshinone derivatives: a literature and patent review. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-22 He Huang,Chuanjun Song,Junbiao Chang
Tanshinones are a class of bioactive compounds present in the Chinese herbal medicine Danshen (Salvia miltiorrhiza Bunge), containing among others abietane diterpene quinone scaffolds. Chemical synthesis and biological activity studies of natural and unnatural tanshinone derivatives have been reviewed in this article.
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Exploring µ-Opioid Receptor Splice Variants as Specific Molecular Target for New Analgesics. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-22 Hirokazu Mizoguchi,Hideaki Fujii
Since an µ-opioid receptor gene containing the multiple exons has been identified, the variety of splice variants for µ-opioid receptors have been reported in various species. Amidino-TAPA and IBNtxA have been discovered as new analgesics with different pharmacological profiles with morphine. These new analgesics show a very potent analgesic effect but do not have dependence liability. Interestingly
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Nanomedicine and early cancer diagnosis: molecular imaging using fluorescence nanoparticles. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-09-22 Ke-Tao Jin,Jia-Yu Yao,Xiao-Jiang Ying,Yan Lin,Yun-Fang Chen
Incorporating nanotechnology into fluorescent imaging and magnetic resonance imaging (MRI) has shown promising potentials for accurate diagnosis of cancer at earlier stage than the conventional imaging modalities. Molecular imaging (MI) aims to quantitatively characterize, visualize, and measure the biological processes or living cells at molecular and genetic levels. MI modalities have been exploited
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Recent Advances in Drug Discovery and Cancer Diagnoses. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Jian Zhang,Haiting Chai
This editorial provides a brief overview of the thematic issue and the papers in it. The thematic issue is proposed to help chemists and biologists track the most recent advances in drug discovery and cancer diagnoses. The process of drug discovery involves the identification and validation of biological targets, the identification and optimization of lead compounds, preclinical development, and clinical
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Current Advances and Limitations of Deep Learning in Anticancer Drug Sensitivity Prediction. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Xian Tan,Yang Yu,Kaiwen Duan,Jingbo Zhang,Pingping Sun,Hui Sun
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Vitamin C as an Anticancer Agent: Regulation of Signaling Pathways. Curr. Topics Med. Chem. (IF 3.218) Pub Date : 2020-08-31 Ghazala Butt,Ammad A Farooqi,Aima Adylova,Rukset Attar,Seher Yilmaz,Konysbayeva K Konysbayevna,Uteuliyev Y Sabitaliyevich,Maria L Gasparri,Baojun Xu
Contents have been reproduced by permission of the publishers.