当前期刊: Current Medicinal Chemistry Go to current issue    加入关注    本刊投稿指南
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Recent Advances in Elucidating Paclitaxel Resistance Mechanisms in Non-small Cell Lung Cancer and Strategies to Overcome Drug Resistance
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-11-30
    Hongmei Cui, Kinsie Arnst, Duane D. Miller and Wei Li

    Paclitaxel (PTX) is a first-line drug for late-stage non-small cell lung cancer (NSCLC) patients who do not benefit from targeted therapy or immunotherapy. However, patients invariably develop resistance to PTX upon prolonged treatments. Although diverse mechanisms leading to PTX resistance have been well-documented in the literature, strategies to overcome PTX resistance in NSCLC based on these mechanisms

    更新日期:2020-11-25
  • Mercury exposure, epigenetic alterations, and brain tumorigenesis: A possible relationship?
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-11-30
    Geir Bjørklund,Lyudmila Pivina,Maryam Dadar,Yuliya Semenova,Salvatore Chirumbolo,Jan Aaseth

    The risk assessment of mercury (Hg), in both wildlife and humans, represents an increasing challenge. Increased production of Reactive Oxygen Species (ROS) is a known Hg-induced toxic effect, which can be accentuated by other environmental pollutants and by complex interactions between environmental and genetic factors. Some epidemiological and experimental studies have investigated a possible correlation

    更新日期:2020-11-25
  • Targeting Ceramide Metabolism in Hepatocellular Carcinoma: New Points for Therapeutic Intervention.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-11-30
    Petra Grbčić,Elitza Petkova Markova Car,Mirela Sedić

    Background: Hepatocellular Carcinoma (HCC) is one of the greatest global health burdens because of its uncontrolled cell growth and proliferation, aggressive nature as well as inherited chemoresistance. In spite of different treatment options currently available for HCC, the 5-year relative survival rates for HCC patients with regional and distant stages of the disease are still low, which highlights

    更新日期:2020-11-25
  • Parthenolide and Its Analogues: A New Potential Strategy for the Treatment of Triple-Negative Breast Tumors.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-11-30
    Thaise Gonçalves Araújo,Lara Vecchi,Paula Marynella Alves Pereira Lima,Everton Allan Ferreira,Igor Moreira Campos,Douglas Cardoso Brandão,Gabriela Silva Guimarães,Matheus Alves Ribeiro,Ademar Alves da Silva Filho

    Triple Negative Breast Cancers (TNBC) are heterogeneous and aggressive pathologies, with distinct morphological and clinical characteristics associated with their genetic diversity, epigenetics, transcriptional changes and aberrant molecular patterns. Treatment with anti-neoplastic drugs exerts systemic effects with low specificity, and incipient improvement in overall survival due to chemoresistance

    更新日期:2020-11-25
  • The role of zinc and copper in insulin resistance and diabetes mellitus.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-11-30
    Geir Bjørklund,Maryam Dadar,Lyudmila Pivina,Monica Daniela Doşa,Yuliya Semenova,Jan Aaseth

    The prevalence of Type 2 Diabetes Mellitus (T2DM) is internationally ever-growing. Therefore, prevention, diagnostics, and control of insulin resistance and T2DM are of increasing importance. It has been suggested that mechanisms leading to insulin resistance and diabetes and its complications include high intake of refined and energy-rich food, which is presumed to be accompanied by suboptimal intake

    更新日期:2020-11-25
  • Diabetic Theory in Anti-Alzheimer's Drug Research and Development. Part 1: Therapeutic Potential of Antidiabetic Agents.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-11-30
    Agnieszka Jankowska,Anna Wesołowska,Maciej Pawłowski,Grażyna Chłoń-Rzepa

    Alzheimer’s Disease (AD) is a chronic and progressive neurodegenerative disorder that affects over 46 million people worldwide. It is characterized by a decline in cognitive abilities, including memory and thinking skills. AD patients also suffer from behavioral and psychological symptoms of dementia of which depression is the most prevalent. Currently available drugs provide modest symptomatic relief

    更新日期:2020-11-25
  • The beneficial actions of SGLT-2 inhibitors beyond management of hyperglycemia.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-11-30
    Charalampos Loutradis,Eirini Papadopoulou,Elena Angeloudi,Asterios Karagiannis,Pantelis Sarafidis

    Type 2 diabetes mellitus (DM) is a public health burden and its co-existence with hypertension is long established in the context of the metabolic syndrome. Both DM and hypertension are major risk factors, for end-stage renal disease, cardiovascular events and mortality. Strict blood pressure (BP) control in diabetics has been associated with a cardiovascular and renal risk decrease. Inhibitors of

    更新日期:2020-11-25
  • Joint Application of Magnetic Resonance Imaging and Biochemical Biomarkers in Diagnosis of Multiple Sclerosis
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-11-30
    Fatemeh Momeni,Amir B. Ghaemmaghami,Majid Nejati,Mohammad Hossein Pourhanifeh,Laleh Shiri Sichani,Omid Reza Tamtaji,Mohammad Momeni,Alireza Khosravi,Masoud Etemadifar,Hamed Mirzaei

    Multiple Sclerosis (MS), an autoimmune disorder associated with spinal cord and brain, chiefly affects the white matter. Regarding the complexity as well as heterogenic etiology of this disease, the treatment of MS has been a challenging issue up to now. Researchers are working to develop new therapeutic strategies and drugs as complementary therapies. MS diagnosis significantly depends on the findings

    更新日期:2020-11-25
  • Epigenetic marks in Polycystic Ovary Syndrome.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-11-30
    Alicia Beatriz Motta

    Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disorder that affects women in their reproductive age. Recent studies have shown that genes have an important role in the etiology of PCOS. However, the precise way in which these genes are transcriptionally and post-transcriptionally regulated is poorly understood. The aim of the present review is to provide updated information on

    更新日期:2020-11-25
  • Neuromedin U and Structural Analogs: an Overview of Their Structure, Function and Selectivity.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-11-30
    An De Prins,Ann Van Eeckhaut,Ilse Smolders,Dirk Tourwé,Steven Ballet

    The neuromedin U peptide sequence is highly conserved between various species. Neuromedin U is involved in a variety of physiological processes. It exerts its effects via two neuromedin U receptors, NMUR1 and NMUR2. These receptors are characterized by a distinct, yet complementary, tissue distribution with NMUR1 mostly found in the periphery, while NMUR2 is most abundant in the central nervous system

    更新日期:2020-11-25
  • Accessing public compound databases with KNIME.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Jennifer Hemmerich,Jana Gurinova,Daniela Digles

    Background: The KNIME platform offers several tools for the analysis of chem- and pharmacoinformatics data. Unless one has sufficient in-house data available for the analysis of interest, it is necessary to fetch third party data into KNIME. Many data sources offer valuable data, but including this data in a workflow is not always straightforward. Objective: Here we discuss different ways of accessing

    更新日期:2020-11-12
  • Ligand- and Structure-Based Drug Design and Optimization using KNIME.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Michael P Mazanetz,Charlotte H F Goode,Ewa I Chudyk

    In recent years there has been a paradigm shift in how data is being used to progress early drug discovery campaigns from hit identification to candidate selection. Significant developments in data mining methods and the accessibility of tools for research scientists have been instrumental in reducing drug discovery timelines and in increasing the likelihood of a chemical entity achieving drug development

    更新日期:2020-11-12
  • VSPrep: A KNIME workflow for the preparation of molecular databases for virtual screening.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    José-Manuel Gally,Stéphane Bourg,Jade Fogha,Quoc-Tuan Do,Samia Aci-Sèche,Pascal Bonnet

    Drug discovery is a challenging and expensive field. Hence, novel in silico tools have been developed in early discovery stage to identify and prioritize novel molecules with suitable physicochemical properties. In many in silico drug design projects, molecular databases are screened by virtual screening tools to search for potential bioactive molecules. The preparation of the molecules is therefore

    更新日期:2020-11-12
  • Five Years of the KNIME Vernalis Cheminformatics Community Contribution.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Stephen Roughley

    Since the official release as a KNIME Community Contribution in June 2013, the Vernalis KNIME nodes have increased from a single node (the ‘PDB Connector’ node) to around 126 nodes (November 2017; Version 1.12.0); furthermore, a number of nodes have been adopted into the core KNIME product. In this review, we provide a brief timeline of the development of the current public release and an overview

    更新日期:2020-11-12
  • Enalos Suite of tools: Enhance Cheminformatics and Nanoinformatics through KNIME.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Antreas Afantitis,Andreas Tsoumanis,Georgia Melagraki

    Drug discovery as well as (nano)material design projects demand the in silico analysis of large datasets of compounds with their corresponding properties/activities, as well as the retrieval and virtual screening of more structures in an effort to identify new potent hits. This is a demanding procedure for which various tools must be combined with different input and output formats. To automate the

    更新日期:2020-11-12
  • The association between depression and gastroesophageal reflux based on phylogenetic analysis of miRNA biomarkers.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Yi-Hau Chen,Hsiuying Wang

    A number of clinical studies have revealed that there is an association between major depression (MD) and gastroesophageal reflux disease (GERD). Both the diseases are shown to affect a large proportion of the global population. More advanced studies for understanding the comorbidity mechanism of these two diseases can shed light on developing new therapies of both diseases. To the best of our knowledge

    更新日期:2020-11-12
  • The Structural Role of Gangliosides: Insights from X-ray Scattering on Model Membranes
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Konstantin Andreev

    Background: Gangliosides are an essential component of eukaryotic plasma membranes implicated in multiple physiological processes. Little is known about molecular mechanisms underlying the distribution and functions of membrane gangliosides. The overwhelmingly complex organization of glycocalyx impedes the structural analysis on cell surface and the interplay between the lipid components. Advanced

    更新日期:2020-11-12
  • Stem Cell Transplant for Advanced Stage Liver Disorders: Current Scenario and Future Prospects.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Anjum Mahmood,Rajasekar Seetharaman,Prashant Kshatriya,Divyang Patel,Anand S Srivastava

    Background: Chronic Liver Disorders (CLD), caused by the lifestyle patterns like alcoholism or by non-alcoholic fatty liver disease or because of virus-mediated hepatitis, affect a large population fraction across the world. CLD progresses into end-stage diseases with a high mortality rate. Liver transplant is the only approved treatment available for such end-stage disease patients. However, the number

    更新日期:2020-11-09
  • Thymosin β4: a multi-faceted tissue repair stimulating protein in heart injury.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Geir Bjørklund,Maryam Dadar,Jan Aaseth,Salvatore Chirumbolo

    Thymosin Beta-4 (Tβ4) is known as a major pleiotropic actin-sequestering protein that is involved in tumorigenesis. Tβ4 is a water-soluble protein that has different promising clinical applications in the remodeling and ulcerated tissues repair following myocardial infarction, stroke, plasticity and neurovascular remodeling of the Peripheral Nervous System (PNS) and the Central Nervous System (CNS)

    更新日期:2020-11-09
  • Protein Interaction Domains and post-translational modifications: structural features and drug discovery applications.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Marian Vincenzi,Flavia Anna Mercurio,Marilisa Leone

    Background: Many pathways regarding healthy cells and/or linked to diseases onset and progression depend on large assemblies including multi-protein complexes. Protein-protein interactions may occur through a vast array of modules known as Protein Interaction Domains (PIDs). Objective: This review concerns with PIDs recognizing post-translationally modified peptide sequences and intends to provide

    更新日期:2020-11-09
  • Osteoporosis: Current and emerging therapies targeted to immunological checkpoints.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Massimo De Martinis,Maria Maddalena Sirufo,Lia Ginaldi

    Osteoporosis is a skeletal pathology characterized by compromised bone strength leading to increased risk of fracture, mainly the spine and hip fractures. Osteoporosis affects more than 200 million people worldwide and because of the skeletal fractures it causes, represents a major cause of morbidity, disability and mortality in older people. Recently, the new discoveries of osteoimmunology have clarified

    更新日期:2020-11-09
  • Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Leila Jouybari,Faezeh Kiani,Farhad Islami,Akram Sanagoo,Fatemeh Sayehmiri,Bozena Hosnedlova,Monica Daniela Doşa,Rene Kizek,Salvatore Chirumbolo,Geir Bjørklund

    Breast cancer is the most common neoplasm, comprising 16% of all women's cancers worldwide. Research of Copper (Cu) concentrations in various body specimens have suggested an association between Cu levels and breast cancer risks. This systematic review and meta-analysis summarize the results of published studies and examine this association. We searched the databases PubMed, Scopus, Web of Science

    更新日期:2020-11-09
  • Heterogeneity and Proliferative and Differential Regulators of NG2-glia in Physiological and Pathological States.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Zuo Zhang,Hongli Zhou,Jiyin Zhou

    NG2-glia, also called Oligodendrocyte Precursor Cells (OPCs), account for approximately 5%-10% of the cells in the developing and adult brain and constitute the fifth major cell population in the central nervous system. NG2-glia express receptors and ion channels involved in rapid modulation of neuronal activities and signaling with neuronal synapses, which have functional significance in both physiological

    更新日期:2020-11-09
  • Insights on nutrients as analgesics in chronic pain.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Geir Bjørklund,Salvatore Chirumbolo,Maryam Dadar,Joeri J Pen,Monica Daniela Doşa,Lyudmila Pivina,Yulia Semenova,Jan Aaseth

    Many serious inflammatory disorders and nutrient deficiencies induce chronic pain, and anti-inflammatory diets have been applied successfully to modify the inflammatory symptoms causing chronic pain. Numerous scientific data and clinical investigations have demonstrated that long-term inflammation could lead to an inappropriate or exaggerated sensibility to pain. In addition, some Non-steroidal Anti-inflammatory

    更新日期:2020-11-09
  • N-acetyl-cysteine in Schizophrenia: Potential Role on the Sensitive Cysteine Proteome
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Marcos Martínez-Banaclocha

    Background: N-acetyl-cysteine (NAC) has shown widespread utility in different psychiatric disorders, including a beneficial role in schizophrenic patients. Although the replenishment of glutathione and the antioxidant activity of NAC have been suggested as the mechanisms that improve such a wide range of disorders, none seems to be sufficiently specific to explain these intriguing effects. A sensitive

    更新日期:2020-11-09
  • Histone Deacetylases (HDACs) in gastric cancer: An update of their emerging prognostic and therapeutic role.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Dimitrios Schizas,Aikaterini Mastoraki,Leon Naar,Diamantis I Tsilimigras,Ioannis Katsaros,Vasiliki Fragkiadaki,Georgia-Sofia Karachaliou,Nikolaos Arkadopoulos,Theodore Liakakos,Dimitrios Moris

    Chemotherapy resistance is a rising concern in Gastric Cancer (GC) and has led to the investigation of various cellular compounds. Α functional equilibrium of histone acetylation and deacetylation was discovered in all cells, regulated by Histone Acetyltransferases and Deacetylases (HDACs), controlling chromatin coiling status and changing gene expression appropriately. In accordance with recent research

    更新日期:2020-11-05
  • The Design and Application of Nanomaterials as Drug Carriers in Cancer Treatment.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Jia Hou,Xiaoyan Sun,Ying Huang,Shaohua Yang,Junjie Liu,Changhao Feng,Jun Ma,Bin Chen

    The development of new medical cancer treatment technologies is of great significance in reducing cancer mortality. Traditional clinical cancer therapy has a short drug action time, difficulty in accurately targeting tumour tissues and high levels of toxicity in normal tissues. With the development of nanotechnology, nanomaterials have been used as drug carriers to specifically target cancer cells

    更新日期:2020-11-05
  • Gonadotropin Releasing Hormone and GnRH Receptor: Structure, Function and Drug Development.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Haralambos Tzoupis,Agathi Nteli,Marilena Androutsou,Theodore Tselios

    Background: Gonadotropin-Releasing Hormone (GnRH) is a key element in sexual maturation and regulation of the reproductive cycle in the human organism. GnRH interacts with the pituitary cells through the activation of the Gonadotropin Releasing Hormone Receptors (GnRHR). Any impairments/dysfunctions of the GnRH-GnRHR complex lead to the development of various cancer types and disorders. Furthermore

    更新日期:2020-11-05
  • Electrochemical and Optical Biosensing Strategies for DNA Methylation Analysis.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    S Zhang,J Huang,J R Lu,M Liu,X Chen,S S Su,F Mo,J S Zheng

    DNA methylation is considered as a crucial part of epigenetic modifications and a popular research topic in recent decades. It usually occurs with a methyl group adding to the fifth carbon atom of cytosine while the base sequence of DNA remains unchanged. DNA methylation has significant influences on maintaining cell functions, genetic imprinting, embryonic development and tumorigenesis procedures

    更新日期:2020-11-05
  • Recent advances in spontaneous Raman spectroscopic imaging: instrumentation and applications.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Nan Wang,Honghao Cao,Lin Wang,Feng Ren,Qi Zeng,Xinyi Xu,Jimin Liang,Yonghua Zhan,Xueli Chen

    Background: Spectroscopic imaging based on the spontaneous Raman scattering effects can provide unique fingerprint information in relation to the vibration bands of molecules. Due to its advantages of high chemical specificity, non-invasive detection capability, low sensitivity to water, and no special sample pretreatment, Raman Spectroscopic Imaging (RSI) has become an invaluable tool in the field

    更新日期:2020-11-05
  • Chemical Mediators Expression Associated with the Modulation of Pain in Rheumatoid Arthritis.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Cortes-Altamirano J L,Morraz-Varela A,Reyes-Long S,Gutierrez M,Cindy Bandala,Clavijo-Cornejo D,Alfaro-Rodriguez A

    Background: The management of pain in patients with rheumatoid arthritis (RA) is a complex subject due to the autoimmune nature of the pathology. Studies have shown that chemical mediators play a fundamental role in the determination, susceptibility and modulation of pain at different levels of the central and peripheral nervous system, resulting in interesting novel molecular targets to mitigate pain

    更新日期:2020-11-05
  • Advances in pharmacological activities and mechanisms of glycyrrhizic acid.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Kun Chen,Rong Yang,Faqian Shen,Hai-Liang Zhu

    Licorice (Glycyrrhiza glabra L.) is widely regarded as an important medicinal plant and has been used for centuries in traditional medicine because of its therapeutic properties. Studies have shown that metabolites isolated from licorice have many pharmacological activities, such as antiinflammatory, anti-viral, participation in immune regulation, anti-tumor and other activities. This article gives

    更新日期:2020-11-05
  • Secondary Metabolites from Deep-sea Derived Microorganisms.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-10-31
    Chunxiao Sun,Shah Mudassir,Zhenzhen Zhang,Yanyan Feng,Yimin Chang,Qian Che,Qianqun Gu,Tianjiao Zhu,Guojian Zhang,Dehai Li

    Microorganisms obtained from the deep sea are a rich source of marine natural products with distinctive chemical structures and bioactivities. In this review, we will provide a retrospective of outstanding research within the scope of deep-sea (≥1000 m) microbial natural products, which has produced up to 442 compounds by the end of 2017. Approximetely, 60% of these structures have demonstrated various

    更新日期:2020-11-05
  • Survey of Similarity-based Prediction of Drug-protein Interactions.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Chen Wang,Lukasz Kurgan

    Therapeutic activity of a significant majority of drugs is determined by their interactions with proteins. Databases of drug-protein interactions (DPIs) primarily focus on the therapeutic protein targets while the knowledge of the off-targets is fragmented and partial. One way to bridge this knowledge gap is to employ computational methods to predict protein targets for a given drug molecule, or interacting

    更新日期:2020-10-30
  • Natural Products as Potential anti-Alzheimer Agents.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Siva S Panda,Nancy Jhanji

    Medicinal plants have curative properties due to the presence of various complex chemical substances of different composition, which are found as secondary metabolites in one or more parts of the plant. The diverse secondary metabolites play an important role in the prevention and cure of various diseases including neurodegenerative diseases like Alzheimer’s disease. Naturally occurring compounds such

    更新日期:2020-10-30
  • Chemical synthesis of acyclic nucleoside phosphonate analogs linked with cyclic systems between the phosphonate and the base moieties.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Guang Huan Shen,Joon Hee Hong

    The syntheses of acyclic nucleoside phosphonate (ANP) analogs linked with cyclic systems are described in the present review. The purpose of the review is to report the methodology of ANP analogs and to give an idea on the synthesis of a therapeutic structural feature of such analogs. The cyclopropane systems were mainly prepared by diazomethane cyclopropanation catalyzed by Pd(OAc)2, intramolecular

    更新日期:2020-10-30
  • Metal-Organic Framework (MOF)-Based Drug Delivery.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Jian Cao,Xuejiao Li,Hongqi Tian

    Background: Developing a controllable drug delivery system is imperative and important to reduce side effects and enhance the therapeutic efficacy of drugs. Metal-organic frameworks (MOFs) an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers have attracted increasing attention in the recent years owing to the unique physical structures possessed

    更新日期:2020-10-30
  • Recent Progress of benzimidazole hybrids for anticancer potential.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Md Jawaid Akhtar,M Shahar Yar,V K Sharma,Ahsan Ahmed Khan,Zulphikar Ali,Md Rafi Haider,Ankita Pathak

    This review presents the detailed account of factors leading to cancer and design strategy for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for cancer treatment in Cancer facts and figures 2017 American Chemical Society has shown progressive development in fighting cancer. Researchers all over the world in both developed and developing countries are in a continuous

    更新日期:2020-10-30
  • Recent progresses in Organic-Inorganic Nano technological platforms for cancer therapeutics.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Sanjay Kumar,Anchal Singhal,Uma Narang,Sweta Mishra,Pratibha Kumari

    Nanotechnology offers promising tools in interdisciplinary research areas and getting an upsurge of interest in cancer therapeutics. Organic nanomaterials and inorganic nanomaterials bring revolutionary advancement in cancer eradication process. Oncology is achieving new heights under nano technological platform by expediting chemotherapy, radiotherapy, photo thermodynamic therapy, bio imaging and

    更新日期:2020-10-30
  • Risk Factors, Mechanisms and Treatments of Thromboangiitis Obliterans: An Overview of Recent Research.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Meng-di Li,Yi Fan Wang,Mei-Wen Yang,Fen-Fang Hong,Shu-Long Yang

    Background: Thromboangiitis obliterans (TAO) is a nonatherosclerotic thromboticocclusive vasculitis that affects the vessels of the small and medium-sized extremities. No explicit etiology or pathogenesis of TAO has been proven, and more effective treatments are needed. Objective: The study aimed to summarize and present an overview of recent advances regarding the risk factors, mechanisms and treatments

    更新日期:2020-10-30
  • Autoimmune Hepatitis and Stellate Cells; an Insight into the Role of Autophagy.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Shahram Golbabapour,Kamran Bagheri-Lankarani,Saeid Ghavami,Bita Geramizadeh

    Autoimmune hepatitis is a necroinflammatory process of liver, featuring interface hepatitis by T cells, macrophages and plasma cells that invade to periportal parenchyma. In this process, a variety of cytokines are secreted and liver tissues undergo fibrogenesis, resulting in the apoptosis of hepatocytes. Autophagy is a complementary mechanism for restraining intracellular pathogens to which the innate

    更新日期:2020-10-30
  • The Next Generation of Pattern Recognition Receptor Agonists: Improving Response Rates in Cancer Immunotherapy.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Daniel H O' Donovan,Yumeng Mao,Deanna A Mele

    The recent success of checkpoint blocking antibodies has sparked a revolution in cancer immunotherapy. Checkpoint inhibition activates the adaptive immune system leading to durable responses across a range of tumor types, although this response is limited to patient populations with pre-existing tumor-infiltrating T cells. Strategies to stimulate the immune system to prime an antitumor response are

    更新日期:2020-10-12
  • Translational Theragnostic of Ovarian Cancer: Where do we stand?
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Maria Grazia Perrone,Oreste Luisi,Anna De Grassi,Savina Ferorelli,Gennaro Cormio,Antonio Scilimati

    Background: Ovarian cancer is the second most common gynecologic malignancy, accounting for approximately 220,000 deaths annually worldwide. Despite radical surgery and initial high response rates to platinum- and taxane-based chemotherapy, most patients experience a relapse, with a median progression-free survival of only 18 months. Overall survival is approximately 30% at 5 years from the diagnosis

    更新日期:2020-10-12
  • Nanomedicine-combined immunotherapy for cancer.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Shigao Huang,Qi Zhao

    Background: Immunotherapy for cancer includes Chimeric Antigen Receptor (CAR)-T cells, CAR-natural Killer (NK) cells, PD1, and the PD-L1 inhibitor. However, the proportion of patients who respond to cancer immunotherapy is not satisfactory. Concurrently, nanotechnology has experienced a revolution in cancer diagnosis and therapy. There are few clinically approved nanoparticles that can selectively

    更新日期:2020-10-12
  • Targeting mitochondria through the use of mitocans as emerging anticancer agents.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Ioana Macasoi,Alexandra Mioc,Marius Mioc,Irina Soica,Adelina Chevereșan,Cristina Dehelean,Victor Dumitrașcu

    Mitochondria are key players with a multi-functional role in many vital cellular processes, such as energy metabolism, redox regulation, calcium homeostasis, Reactive Oxygen Species (ROS) as well as in cell signaling, survival and apoptosis. These functions are mainly regulated through important enzyme signaling cascades, which if altered may influence the outcome of cell viability and apoptosis. Therefore

    更新日期:2020-10-12
  • Progress in Research on Tumor Metastasis Inhibitors.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Weiqi Xia,Chunqi Hu

    Tumor metastasis is a significant cause of malignant cancer-related death. Therefore, inhibiting tumor metastasis is an effective means of treating malignant tumors. Increasing our understanding of the molecular mechanisms that govern tumor metastasis can reveal new anti-cancer targets. This article will discuss the breakthroughs in this area and the corresponding recent developments in anti-cancer

    更新日期:2020-10-12
  • An overview of injectable thermo-responsive hydrogels and advances in their biomedical applications.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Fabián Ávila-Salas,Esteban F Durán-Lara

    Background: Injectable hydrogels are a thermo-responsive system based on biomaterials. Injectable hydrogels have been broadly investigated mainly as vehicles or scaffolds of therapeutic agents that include drugs, proteins, cells, and bioactive molecules among others, utilized in the treatment of diseases such as cancers and the repair and regeneration of tissues. Results: There are several studies

    更新日期:2020-10-12
  • Natural Products for the Treatment of Neurodegenerative Diseases.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Ze Wang,Chunyang He,Jing-Shan Shi

    Neurodegenerative diseases are a heterogeneous group of disorders characterized by the progressive degeneration of the structure and function of the central nervous system or peripheral nervous system. Alzheimer's Disease (AD), Parkinson's Disease (PD) and Spinal Cord Injury (SCI) are the common neurodegenerative diseases, which typically occur in people over the age of 60. With the rapid development

    更新日期:2020-10-12
  • Toll-like receptors as potential therapeutic targets in kidney diseases.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Qian Ren,Lu Cheng,Jing Yi,Liang Ma,Jing Pan,Shen-Ju Gou,Ping Fu

    Toll-like Receptors (TLRs) are members of pattern recognition receptors and serve a pivotal role in host immunity. TLRs response to pathogen-associated molecular patterns encoded by pathogens or damage-associated molecular patterns released by dying cells, initiating an inflammatory cascade, where both beneficial and detrimental effects can be exerted. Accumulated evidence has revealed that TLRs are

    更新日期:2020-10-12
  • Small Molecules with Anti Prion Activity.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Carlo Mustazza,Marco Sbriccoli,Paola Minosi,Carla Raggi

    Prion pathologies are fatal neurodegenerative diseases caused by the misfolding of the physiological Prion Protein (PrPC) into a β-structure-rich isoform called PrPSc. To date, there is no available cure for prion diseases and just a few clinical trials have been carried out. The initial approach in the search of anti-prion agents had PrPSc as a target, but the existence of different prion strains

    更新日期:2020-10-08
  • Nanomedicines for subcellular targeting: the mitochondrial perspective.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Olakunle Oladimeji,Jude Akinyelu,Moganavelli Singh

    Background: Over the past decade, there has been a surge in the number of mitochondrialactive therapeutics for conditions ranging from cancer to aging. Subcellular targeting interventions can modulate adverse intracellular processes unique to the compartments within the cell. However, there is a dearth of reviews focusing on mitochondrial nano-delivery, and this review seeks to fill this gap with regards

    更新日期:2020-10-08
  • The role of NIR fluorescence in MDR cancer treatment: From targeted imaging to phototherapy.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Zengtao Wang,Qingqing Meng,Shaoshun Li

    Background: Multidrug Resistance (MDR) is defined as a cross-resistance of cancer cells to various chemotherapeutics and has been demonstrated to correlate with drug efflux pumps. Visualization of drug efflux pumps is useful to pre-select patients who may be insensitive to chemotherapy, thus preventing patients from unnecessary treatment. Near-Infrared (NIR) imaging is an attractive approach to monitoring

    更新日期:2020-10-08
  • The development of inhibitors targeting the Mixed lineage leukemia 1 (MLL1)-WD repeat domain 5 protein (WDR5) Protein-Protein Interaction.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Xiaoqing Ye,Gang Chen,Jia Jin,Binzhong Zhang,Yinda Wang,Fei Ye

    Mixed Lineage Leukemia 1 (MLL1), an important member of Histone Methyltransferases (HMT) family, is capable of catalyzing mono-, di-, and trimethylation of Histone 3 lysine 4 (H3K4). The optimal catalytic activity of MLL1 requires the formation of a core complex consisting of MLL1, WDR5, RbBP5, and ASH2L. The Protein-Protein Interaction (PPI) between WDR5 and MLL1 plays an important role in abnormal

    更新日期:2020-10-08
  • The CXCL12-CXCR4 signaling axis plays a key role in cancer metastasis and is a potential target for developing novel therapeutics against metastatic cancer.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Ping Yang,Yae Hu,Quansheng Zhou

    Metastasis is the main cause of death in cancer patients; there is currently no effective treatment for cancer metastasis. This is primarily due to our insufficient understanding of the metastatic mechanisms in cancer. An increasing number of studies have shown that the C-X-C motif chemokine Ligand 12 (CXCL12) is overexpressed in various tissues and organs. It is a key niche factor that nurtures the

    更新日期:2020-10-08
  • Small Molecular Gemcitabine Prodrugs for Cancer Therapy.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    He Miao,Xuehong Chen,Yepeng Luan

    Gemcitabine as a pyrimidine nucleoside analog anticancer drug has high efficacy for a broad spectrum of solid tumors. Gemcitabine is activated within tumor cells by sequential phosphorylation carried out by deoxycytidine kinase to mono-, di-, and triphosphate nucleotides with the last one as the active form. But the instability, drug resistance and toxicity severely limited its utilization in clinics

    更新日期:2020-10-08
  • Recent Advances in the Development of CBP/p300 Bromodomain Inhibitors.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Ying Xiong,Mingming Zhang,Yingxia Li

    CBP and p300 are two closely related Histone Acetyltransferases (HATs) that interact with numerous transcription factors and act to increase the expression of their target genes. Both proteins contain a bromodomain flanking the HAT catalytic domain that is important in binding of CBP/p300 to chromatin, which offers an opportunity to develop protein-protein interaction inhibitors. Since their discovery

    更新日期:2020-10-08
  • Fluorine-Containing Inhalation Anesthetics: Chemistry, Properties, and Pharmacologies.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-30
    Yuzhong Wang,Xiao-Xia Ming,Cheng-Pan Zhang

    Studies on fluorinated inhalation anesthetics, including synthesis, physical chemistry and pharmacology, have been summarized in this review. Retrospecting the history of inhalation anesthetics revealed their increasing reliance on fluorine and ether structures. Halothane causes a rare but severe immune-based hepatotoxicity, which was replaced by enflurane in the 1970s. Isoflurane replaced enflurane

    更新日期:2020-10-08
  • Genotype Driven Therapy for Non-Small Cell Lung Cancer: Resistance, Pan Inhibitors and Immunotherapy.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Sitanshu S Singh,Achyut Dahal,Leeza Shrestha,Seetharama D Jois

    Eighty-five percent of patients with lung cancer present with Non-small Cell Lung Cancer (NSCLC). Targeted therapy approaches are promising treatments for lung cancer. However, despite the development of targeted therapies using Tyrosine Kinase Inhibitors (TKI) as well as monoclonal antibodies, the five-year relative survival rate for lung cancer patients is still only 18%, and patients inevitably

    更新日期:2020-09-25
  • Metabolic reprogramming of cancer by chemicals that target glutaminase isoenzymes.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    José M Matés,José A Campos-Sandoval,Juan de Los Santos-Jiménez,Juan A Segura,Francisco J Alonso,Javier Márquez

    Background: Metabolic reprogramming of tumours is a hallmark of cancer. Among the changes in the metabolic network of cancer cells, glutaminolysis is a key reaction altered in neoplasms. Glutaminase proteins control the first step in glutamine metabolism and their expression correlates with malignancy and growth rate of a great variety of cancers. The two types of glutaminase isoenzymes, GLS and GLS2

    更新日期:2020-09-25
  • A review of drug repositioning based chemical-induced cell line expression data.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Fei Wang,Xiujuan Lei,Fang-Xiang Wu

    Drug repositioning is an important area of biomedical research. The drug repositioning studies have shifted to computational approaches. Large-scale perturbation databases, such as the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures, contain a number of chemical-induced gene expression profiles and provide great opportunities for computational biology and drug repositioning

    更新日期:2020-09-25
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
施普林格,自然编辑
ERIS期刊投稿
欢迎阅读创刊号
自然职场,为您触达千万科研人才
spring&清华大学出版社
城市可持续发展前沿研究专辑
Springer 纳米技术权威期刊征稿
全球视野覆盖
施普林格·自然新
chemistry
物理学研究前沿热点精选期刊推荐
自然职位线上招聘会
欢迎报名注册2020量子在线大会
化学领域亟待解决的问题
材料学研究精选新
GIANT
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
ACS Publications填问卷
阿拉丁试剂right
苏州大学
林亮
南方科技大学
朱守非
胡少伟
有机所林亮
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
上海纽约大学
浙江大学
廖矿标
天合科研
x-mol收录
试剂库存
down
wechat
bug