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  • Repurposing of the PDE5 inhibitor sildenafil for treatment of persistent pulmonary hypertension in neonates.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-23
    Erika L Poitras,Stephen L Gust,Paul M Kerr,Frances Plane

    Nitric oxide (NO), an important endogenous signalling molecule released from vascular endothelial cells and nerves, activates the enzyme soluble guanylate cyclase to catalyze production of cyclic guanosine monophosphate (cGMP) from guanosine triphosphate. cGMP, in turn, activates protein kinase G to phosphorylate a range of effector proteins in smooth muscle cells that reduce intracellular Ca2+ levels

    更新日期:2020-09-23
  • Indole derivatives as anti-tubercular agents: An overview on their synthesis and biological activities.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-18
    Gangireddy Sujeevan Reddy,Manojit Pal

    BACKGROUND The indole framework is considered as one of the privileged structures in the area of medicinal chemistry and drug discovery because compounds containing this framework have shown to possess remarkable ability to bind with many receptors or proteins with high affinity. It is therefore not surprising that indole nucleus is a frequently found moiety in many bioactive agents or drugs. Indole

    更新日期:2020-09-18
  • Resveratrol, a Molecule with Anti-Inflammatory and Anti-Cancer Activities: Natural Product to Chemical Synthesis.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-17
    Tsong-Long Hwang,Sunil Kumar,Yu-Chia Chang,Kuei-Hung Lai

    BACKGROUND Resveratrol, a natural polyphenol product, is used in plant defense from fungal and microbial aggression. It is found naturally, especially in plants such as grapes, peanuts, and berries. It has the highest concentrations in blueberries, mulberries, blackberries, and the skin of red grapes. Resveratrol has various pharmacological properties such as anti-inflammatory, cytoprotective, and

    更新日期:2020-09-17
  • Natural COX-2 inhibitors as promising anti-inflammatory agents: an update.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-17
    Jiahua Cui,Jinping Jia

    COX-2, a key enzyme that catalyzed the rate-limiting steps in the conversion of arachidonic acid to prostaglandins, played a pivotal role in inflammatory process. Different from other family members, COX-2 was barely detectable in normal physiological conditions and highly inducible during acute inflammatory response of human bodies to injuries or infections. Therefore, the therapeutic utilization

    更新日期:2020-09-17
  • Biomarkers of senescence during aging as possible warnings to use preventive measures.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-17
    Amin Gasmi,Salvatore Chirumbolo,Massimiliano Peana,Pavan Kumar Mujawdiya,Maryam Dadar,Alain Menzel,Geir Bjørklund

    Human life expectancy is increasing significantly over time thanks to the improved possibility of taking care of themselves and the higher availability of food, drugs, hygiene, services, and assistance. The increase in the average age of the population worldwide is, however, becoming a real concern, since aging is associated with the rapid increase in chronic inflammatory pathologies and degenerative

    更新日期:2020-09-17
  • Diabetic Theory in Anti-Alzheimer's Drug Research and Development. Part 2: Therapeutic Potential of cAMP-Specific Phosphodiesterase Inhibitors.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-17
    Agnieszka Jankowska,Maciej Pawłowski,Grażyna Chłoń-Rzepa

    Alzheimer's Disease (AD) is one of the most prevalent age-related neurodegenerative diseases that affect the cognition, behavior, and daily activities of individuals. Studies indicate that this disease is characterized by several pathological mechanisms, including the accumulation of amyloid beta peptide, hyperphosphorylation of tau protein, impairment of cholinergic neurotransmission, and increase

    更新日期:2020-09-17
  • Novel Vaccine Candidates against Tuberculosis.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Zhihao Li,Changping Zheng,Marco Terreni,Lisa Tanzi,Matthieu Sollogoub,Yongmin Zhang

    Ranking above AIDS, Tuberculosis (TB) is the ninth leading cause of death affecting and killing many individuals every year. Drugs’ efficacy is limited by a series of problems such as Multi- Drug Resistance (MDR) and Extensively-Drug Resistance (XDR). Meanwhile, the only licensed vaccine BCG (Bacillus Calmette-Guérin) existing for over 90 years is not effective enough. Consequently, it is essential

    更新日期:2020-09-11
  • Microbiota, Immune System and Autism Spectrum Disorders: An Integrative Model towards Novel Treatment Options.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Barbara Carpita,Donatella Marazziti,Lionella Palego,Gino Giannaccini,Laura Betti,Liliana Dell'Osso

    Background: Autism Spectrum Disorder (ASD) is a condition strongly associated with genetic predisposition and familial aggregation. Among ASD patients, different levels of symptoms severity are detectable, while the presence of intermediate autism phenotypes in close relatives of ASD probands is also known in literature. Recently, increasing attention has been paid to environmental factors that might

    更新日期:2020-09-11
  • Reviewing Biochemical Implications of Normal and Mutated Huntingtin in Huntington's Disease.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Ester Tellone,Antonio Galtieri,Silvana Ficarra

    Huntingtin (Htt) is a multi-function protein of the brain. Normal Htt shows a common alpha-helical structure but conformational changes in the form with beta strands are the principal cause of Huntington’s disease. Huntington’s disease is a genetic neurological disorder caused by a repeated expansion of the CAG trinucleotide, causing instability in the N-terminal of the gene coding for the Huntingtin

    更新日期:2020-09-11
  • Structure and Function of Angiopoietin-like Protein 3 (ANGPTL3) in Atherosclerosis.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Xinjie Lu

    Background: Angiopoietin-Like Proteins (ANGPTLs) are structurally related to the angiopoietins. A total of eight ANGPTLs (from ANGPTL1 to ANGPTL8) have been identified so far. Most ANGPTLs possess multibiological functions on lipid metabolism, atherosclerosis, and cancer. Among them, ANGPTL3 has been shown to regulate the levels of Very Low-Density Lipoprotein (VLDL) made by the liver and play a crucial

    更新日期:2020-09-11
  • Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Qingjun Pan,Yun Guo,Linjie Guo,Shuzhen Liao,Chunfei Zhao,Sijie Wang,Hua-Feng Liu

    Systemic Lupus Erythematosus (SLE) is a chronic and relapsing heterogenous autoimmune disease that primarily affects women of reproductive age. Genetic and environmental risk factors are involved in the pathogenesis of SLE, and susceptibility genes have recently been identified. However, as gene therapy is far from clinical application, further investigation of environmental risk factors could reveal

    更新日期:2020-09-11
  • Nanostructured Calcium-based Biomaterials and their Application in Drug Delivery.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Li-Juan Yi,Jun-Feng Li,Ming-Guo Ma,Ying-Jie Zhu

    In the past several decades, various types of nanostructured biomaterials have been developed. These nanostructured biomaterials have promising applications in biomedical fields such as bone repair, tissue engineering, drug delivery, gene delivery, antibacterial agents, and bioimaging. Nanostructured biomaterials with high biocompatibility, including calcium phosphate, hydroxyapatite, and calcium silicate

    更新日期:2020-09-11
  • Metal Complexes as Promising Agents for Biomedical Applications.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Natalia V Loginova,Hleb I Harbatsevich,Nikolai P Osipovich,Galina A Ksendzova,Tatsiana V Koval'chuk,Genrikh I Polozov

    Background: In this review article, a brief overview of novel metallotherapeutic agents (with an emphasis on the complexes of essential biometals) promising for medical application is presented. We have also focused on the recent work carried out by our research team, specifically the development of redox-active antimicrobial complexes of sterically hindered diphenols with some essential biometals

    更新日期:2020-09-11
  • Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Rodrigo Valenzuela,Macarena Ortiz,María Catalina Hernández-Rodas,Francisca Echeverría,Luis Alberto Videla

    Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by abnormal hepatic accumulation of triacylglycerides in the absence of alcohol consumption, in association with Oxidative Stress (OS), a pro-inflammatory state and Insulin Resistance (IR), which are attenuated by n-3 long-chain polyunsaturated Fatty Acids (FAs) C20-C22 (LCPUFAs) supplementation. Main causes of NAFLD comprise high

    更新日期:2020-09-11
  • Structural Basis of Drug Recognition by Human Serum Albumin.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Loris Leboffe,Alessandra di Masi,Fabio Polticelli,Viviana Trezza,Paolo Ascenzi

    Background: Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-domain macromolecule with at least nine binding sites for endogenous and exogenous ligands. HSA displays an extraordinary ligand binding capacity as a depot and carrier for many compounds including most acidic drugs. Consequently, HSA has the potential to influence the pharmacokinetics and pharmacodynamics

    更新日期:2020-09-08
  • Quaternized Chitosan Nanoparticles in Vaccine Applications.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Shuang Yu,Shengnan Hao,Beini Sun,Dongying Zhao,Xingye Yan,Zheng Jin,Kai Zhao

    Different natural and synthetic biodegradable polymers have been used in vaccine formulations as adjuvant and delivery system but have faced various limitations. Chitosan is a new delivery system with the potential to improve development of nano vaccines and drugs. However, chitosan is only soluble in acidic solutions of low concentration inorganic acids such as dilute acetic acid and dilute hydrochloric

    更新日期:2020-09-08
  • Discovery of Dengue Virus Inhibitors.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Adib Afandi Abdullah,Yean Kee Lee,Sek Peng Chin,See Khai Lim,Vannajan Sanghiran Lee,Rozana Othman,Shatrah Othman,Noorsaadah Abdul Rahman,Rohana Yusof,Choon Han Heh

    To date, there is still no approved anti-dengue agent to treat dengue infection in the market. Although the only licensed dengue vaccine, Dengvaxia is available, its protective efficacy against serotypes 1 and 2 of dengue virus was reported to be lower than serotypes 3 and 4. Moreover, according to WHO, the risk of being hospitalized and having severe dengue increased in seronegative individuals after

    更新日期:2020-09-08
  • Research Advances in Chitosan Oligosaccharides: From Multiple Biological Activities to Clinical Applications.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Zhen Yi,Xiao Luo,Lei Zhao

    Chitosan oligosaccharides (COS), hydrolysed products of chitosan, are low-molecular weight polymers with a positive charge and good biocompatibility. COS have recently been reported to possess various biological activities, including hypoglycaemic, hypolipidaemic, antioxidantantioxidant, immune regulation, anti-inflammatory, antitumour, antibacterial, and tissue engineering activities, exhibiting extensive

    更新日期:2020-09-08
  • Mechanistic Insights of Soluble Uric Acid-related Kidney Disease.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Jing Pan,Min Shi,Liang Ma,Ping Fu

    Hyperuricemia, defined as the presence of elevated serum uric acid (sUA), could lead to urate deposit in joints, tendons, kidney and other tissues. Hyperuricemia as an independent risk factor was common in patients during the causation and progression of kidney disease. Uric acid is a soluble final product of endogenous and dietary purine metabolism, which is freely filtered in kidney glomeruli where

    更新日期:2020-09-08
  • LncRNAs: Potential Novel Prognostic and Diagnostic Biomarkers in Colorectal Cancer.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Narges Dastmalchi,Reza Safaralizadeh,Mirsaed Miri Nargesi

    Background: Long non-coding RNAs (lncRNAs), a type of regulatory RNAs, play a key role in numerous cellular pathways. Ectopic expression of this group of non-coding RNAs has been specified to be involved in numerous diseases. Moreover, the role of lncRNAs in the initiation and development of cancers including colorectal cancer (CRC) has been acknowledged. Objective: In the present review, the role

    更新日期:2020-09-08
  • Pathophysiological Role and Drug Modulation of Calcium Transport in Ocular Surface Cells.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Chen-Chen Chu,Shao-Zhen Zhao

    The ocular surface structure and extraocular accessory organs constitute the ocular surface system, which includes the cornea, conjunctiva, eyelids, lacrimal organs, and lacrimal passages. This system is composed of, and stabilized by, the corneal epithelium, conjunctival cells, conjunctival goblet cells, lacrimal acinar cells and Tenon’s fibroblasts, all of which maintain the healthy eyeball surface

    更新日期:2020-09-08
  • Monoclonal antibodies, small molecule inhibitors and antibody-drug conjugates as HER2 inhibitors.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-08
    Xiu-Fang Li,Chen-Fu Liu,Guo-Wu Rao

    Overexpression of human epidermal growth factor receptor (HER)-2 is found in a variety of cancers, often portending poor clinical outcomes. Therefore, HER2 is an attractive target for treatment. This review describes the research progress of HER2 targeted inhibitors in recent years. Excellent reviews are available, so we focus on the development, mechanisms of action, and structure-activity relationships

    更新日期:2020-09-08
  • Metformin: A Growing Journey from Glycemic Control to the Treatment of Alzheimer's Disease and Depression.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-08
    Mohamed El Massry,Lynn M Alaeddine,Leen Ali,Celine Saad,Assaad A Eid

    Metabolic stress, transduced as an altered cellular redox and energy status, presents as the main culprit in many diseases including diabetes. However, its role in the pathology of neurological disorders is still not fully elucidated. Metformin, a biguanide compound, is an FDA approved antidiabetic drug generally used for the treatment of type 2 diabetes. The recently described wide spectrum of action

    更新日期:2020-09-08
  • Repurposing of Acriflavine to target Chronic Myeloid Leukemia treatment.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-08
    Rawan Nehme,Rawan Hallal,Maya El Dor,Firas Kobeissy,Fabrice Gouilleux,Frédéric Mazurier,Kazem Zibara

    Drug repurposing has lately received increasing interest in several diseases especially in cancers due to its advantages in facilitating the development of new therapeutic strategies, by adopting a cost-friendly approach and avoiding the strict Food and Drug Administration (FDA) regulations. Acriflavine (ACF) is an FDA approved molecule that has been extensively studied since 1912 with antiseptic,

    更新日期:2020-09-08
  • Current scenario and future prospect in the management of COVID-19.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-08
    Pobitra Borah,Pran Kishore Deb,Satyendra Deka,Katharigatta N Venugopala,Vinayak Singh,Raghu Prasad Mailavaram,Kiran Kalia,Rakesh Kumar Tekade

    The COVID-19 pandemic continues to wreak havoc worldwide due to the lack of risk assessment, rapid spreading ability, and propensity to precipitate severe disease in comorbid conditions. In an attempt to fulfill the demand for prophylactic and treatment measures to intercept the ongoing outbreak, the drug development process is facing several obstacles and renaissance in clinical trials, including

    更新日期:2020-09-08
  • Antidepressants and antipsychotic agents as repurposable oncological drug candidates.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-07
    Michał Antoszczak,Anna Markowska,Janina Markowska,Adam Huczyński

    Drug repurposing, known also as drug repositioning/reprofiling, is a relatively new strategy for identification of alternative uses of well-known therapeutics that are outside the scope of their original medical indications. Such an approach might entail a number of advantages compared to standard de novo drug development, including less time needed to introduce the drug to the market, and lower costs

    更新日期:2020-09-07
  • Deep Learning in Drug Target Interaction Prediction: Current and Future Perspective.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-07
    Karim Abbasi,Parvin Razzaghi,Antti Poso,Saber Ghanbari-Ara,Ali Masoudi-Nejad

    Drug-target Interactions (DTIs) prediction plays a central role in drug discovery. Computational methods in DTIs prediction have gotten more attention because carrying out in vitro and in vivo experiments on a large scale is costly and time-consuming. Machine learning methods, especially deep learning, are widely applied to DTIs prediction. In this study, the main goal is to provide a comprehensive

    更新日期:2020-09-07
  • 3D Culture Modelling: An Emerging Approach for Translational Cancer Research in Sarcomas.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Victoria Heredia-Soto,Andrés Redondo,José Juan Pozo Kreilinger,Virginia Martínez-Marín,Alberto Berjón,Marta Mendiola

    Sarcomas are tumours of mesenchymal origin, which can arise in bone or soft tissues. They are rare but frequently quite aggressive and with a poor outcome. New approaches are needed to characterise these tumours and their resistance mechanisms to current therapies, responsible for tumour recurrence and treatment failure. This review is focused on the potential of three-dimensional (3D) in vitro models

    更新日期:2020-09-03
  • Current Translational and Clinical Challenges in Advanced Hepatocellular Carcinoma.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Melissa Frizziero,Mairéad G McNamara,Angela Lamarca,Rille Pihlak,Roopa Kurup,Richard A Hubner

    Hepatocellular carcinoma (HCC) is a frequent and increasing cause of cancerrelated deaths worldwide. Reversing this trend is complicated by the varied aetiological factors leading to liver cirrhosis resulting in molecular genetic and clinical heterogeneity, combined with frequent presentation at advanced stage. Large-scale genomic studies have identified alterations in key signalling pathways for HCC

    更新日期:2020-09-03
  • Clinical and Translational Challenges in Thyroid Cancer.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Jorge Hernando,Javier Ros,Alvaro Arroyo,Jaume Capdevila

    Thyroid cancer is the most common endocrine malignancy and it accounts for 1% of all newly diagnosed tumors. Approximately 10% of patients with differentiated thyroid carcinomas (DTC) and 30% with medullary thyroid carcinoma (MTC) could not be cured with locoregional treatment and could develop metastatic disease. In addition, one of the most aggressive solid tumors can arise from the thyroid gland

    更新日期:2020-09-03
  • Clinical and Translational Research Challenges in Neuroendocrine Tumours.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Jorge Barriuso,Angela Lamarca

    Neuroendocrine tumours (NETs) represent a range of neoplasms that may arise from any (neuro)endocrine cell situated in any part of the human body. As any other rare diseases, NETs face several difficulties in relation to research. This review will describe some of the main challenges and proposed solutions faced by researchers with expertise in rare malignancies. Some of the most common challenges

    更新日期:2020-09-03
  • In Vitro Immunodetection of Prothymosin Alpha in Normal and Pathological Conditions.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Chrysoula-Evangelia Karachaliou,Hubert Kalbacher,Wolfgang Voelter,Ourania E Tsitsilonis,Evangelia Livaniou

    Prothymosin alpha (ProTα) is a highly acidic polypeptide, ubiquitously expressed in almost all mammalian cells and tissues and consisting of 109 amino acids in humans. ProTα is known to act both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a biologic response modifier mediating immune responses similar to molecules termed as “alarmins”. Antibodies and immunochemical

    更新日期:2020-09-03
  • Magnetic Digital Microfluidics for Point-of-Care Testing: Where Are We Now?
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-03
    Yi Zhang

    Point-of-care (POC) testing decentralizes the diagnostic tests to the sites near the patient. Many POC tests rely microfluidic platforms for sample-to-answer analysis. Compared to other microfluidic systems, magnetic digital microfluidics demonstrate compelling advantages for POC diagnostics. In this review, we have examined the capability of magnetic digital microfluidics-based POC diagnostic platforms

    更新日期:2020-09-03
  • Targeting COVID-19 in Parkinson's patients: Drugs repurposed.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-03
    Firoz Anwar,Salma Naqvi,Fahad A Al-Abbasi,Nauroz Neelofar,Vikas Kumar,Ankit Sahoo,Mohammad Amjad Kamal

    The last couple of months have witnessed the world in a state of virtual standstill. The SARS-CoV-2 virus has overtaken globe to economic and social lockdown. Many patients with COVID-19 have compromised immunity, especially in an aged population suffering from Parkinson disease (PD). Alteration in dopaminergic neurons or deficiency of dopamine in PD patients is the most common symptoms affecting 1%

    更新日期:2020-09-03
  • Repurposing cilostazol for Raynaud's phenomenon.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-03
    Nehme El-Hachem,Manal M Fardoun,Hasan Slika,Elias Baydoun,Ali H Eid

    Raynaud's Phenomenon (RP) results from exaggerated cold-induced vasoconstriction. RP patients suffer from vasospastic attacks and compromised digital blood perfusion leading to triple color change at the level the fingers. Severe RP may cause ulcers and threaten tissue viability. Many drugs have been used to alleviate the symptoms of RP. These include calcium-channel blockers, cGMP-specific phosphodiesterase

    更新日期:2020-09-03
  • Renin-angiotensin system (RAS) and immune system profile in specific subgroups with COVID-19.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-03
    Ludimila de Barcelos Ubaldo Martins,Luiz Gustavo Pessoa Pires Jabour,Cristina Cerqueira Vieira,Lucas Crepaldi Carvalho Nery,Raphael Figuiredo Dias,Ana Cristina Simões E Silva

    BACKGROUND The identification of vulnerable subgroups and risk factors associated with the susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) are of utmost importance in a pandemic scenario. Potential interactions between renin-angiotensin system (RAS), immune markers and COVID-19 play a role in disease outcome in specific

    更新日期:2020-09-03
  • Clinical and Translational Research Challenges in Biliary Tract Cancers.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Angela Lamarca,Melissa Frizziero,Mairéad G McNamara,Juan W Valle

    Background: Biliary Tract Cancers (BTC) are rare malignancies with a poor prognosis. There are many challenges encountered in treating these patients in daily practice as well as in clinical, translational and basic research. Objective: This review summarises the most relevant challenges in clinical and translational research in BTCs and suggests potential solutions towards an improvement in quality

    更新日期:2020-09-02
  • Self-assembling Peptides in Current Nanomedicine: Versatile Nanomaterials for Drug Delivery.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Fei Peng,Wensheng Zhang,Feng Qiu

    Background: The development of modern nanomedicine greatly depends on the involvement of novel materials as drug delivery system. In order to maximize the therapeutic effects of drugs and minimize their side effects, a number of natural or synthetic materials have been widely investigated for drug delivery. Among these materials, biomimetic self-assembling peptides (SAPs) have received more attention

    更新日期:2020-09-02
  • Role of Antioxidant Molecules and Polymers in Prevention of Bacterial Growth and Biofilm Formation.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Iolanda Francolini,Antonella Piozzi

    Background: Antioxidants are multifaceted molecules playing a crucial role in several cellular functions. There is by now a well-established knowledge about their involvement in numerous processes associated with aging, including vascular damage, neurodegenerative diseases and cancer. An emerging area of application has been lately identified for these compounds in relation to the recent findings indicating

    更新日期:2020-09-02
  • Sigma-2 Receptor as a Potential Drug Target.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-09-02
    Ai-Fang Cheng,Wen-Hui Ma,Xiao-Yang Xie,Yun-Sheng Huang

    Sigma-2 receptor plays key roles in promoting tumor cell apoptosis, enhancing efficacy of anti-tumor drugs, blocking signal transduction controlled by Aβ oligomers, regulating Ca2+ homeostasis and protecting nerve cells. Studies indicated that sigma-2 receptor may be closely coupled with ROS, LDL, mTOR, RAS, PLC/PKC, lysosomal autophagy and mitochondrial super oxidative stress. In addition, the high

    更新日期:2020-09-02
  • Tackling Alzheimer's Disease with Existing Drugs: Playing Dirty for Bypassing Obstacles.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Angela Rampa,Silvia Gobbi,Federica Belluti,Alessandra Bisi

    The unmet need for the development of effective drugs to treat Alzheimer's disease has been steadily growing, representing a major challenge in drug discovery. In this context, drug repurposing, namely the identification of novel therapeutic indications for approved or investigational compounds, can be seen as an attractive attempt to obtain new medications reducing both the time and the economic burden

    更新日期:2020-08-31
  • Prospects for the Use of Sialidase Inhibitors in Anti-atherosclerotic Therapy.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Igor A Sobenin,Alexander M Markin,Victor Y Glanz,Yuliya V Markina,Wei-Kai Wu,Veronika A Myasoedova,Alexander N Orekhov

    The most typical feature of atherogenesis in humans at its early stage is the formation of foam cells in subendothelial arterial intima, which occurs as the consequence of intracellular cholesterol deposition. The main source of lipids accumulating in the arterial wall are circulating low-density lipoprotein (LDL). However, LDL particles should undergo proatherogenic modification to acquire atherogenic

    更新日期:2020-08-31
  • Functional Role of Glycosphingolipids in Cancer.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Changping Zheng,Marco Terreni,Matthieu Sollogoub,Yongmin Zhang

    Glycosphingolipids (GSLs) are ubiquitous components on animal cell membranes, and exposed on the outer surface. Various studies have demonstrated that they play key roles in cells proliferation, adhesion, motility and differentiation. Usually, the specific types of GSLs are expressed more highly in tumors than in normal tissues, which are known as tumorassociated antigens. It has been revealed that

    更新日期:2020-08-31
  • Nanotechnology-based drug delivery systems as potential for skin application: a review.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Franciele Garcia Baveloni,Bruno Vincenzo Fiod Riccio,Leonardo Delello Di Filippo,Mariza Aires Fernandes,Andréia Bagliotti Meneguin,Marlus Chorilli

    Administration of substances through the skin represents a promising alternative, in relation to others drug administration routes, due to its large body surface area, in order to offer ideal and multiple sites for drug administration. In addition, the administration of drugs through the skin avoids first-pass metabolism, allowing an increase in the bioavailability of drugs, as well as reducing their

    更新日期:2020-08-31
  • Perspectives on Drug Repurposing.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-31
    Alejandro Schcolnik-Cabrera,Daniel Juárez-López,Alfonso Duenas-Gonzalez

    Complex common diseases are a significant burden for our societies and demand not only preventive measures but also more effective, safer, and more affordable treatments. The whole process of the current model of drug discovery and development implies a high investment by the pharmaceutical industry, which ultimately impact in high drug prices. In this sense, drug repurposing would help meet the needs

    更新日期:2020-08-31
  • Central regulatory role of cytokines in periodontitis and targeting options.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-24
    Grigorios Plemmenos,Evangelos Evangeliou,Nikolaos Polizogopoulos,Andreas Chalazias,Marianthi Deligianni,Christina Piperi

    Periodontitis is an immune-inflammatory disease that leads to the progressive destruction of bone and connective tissue in the periodontal area. The cytokine network plays a primary role in tissue homeostasis, the recruitment of immune cells to control the pathogenic impact and the regulation of osteoclastic function, thus modulating the intensity and duration of immune response. This review provides

    更新日期:2020-08-24
  • Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-24
    Amin Gasmi,Sadaf Noor,Alain Menzel,Alexandru Doşa,Lyudmila Pivina,Geir Bjørklund

    Obesity is known to be a multifactorial disease. In its pathogenesis, different factors such as chronic inflammation, oxidative stress, insulin resistance, genetic factors, environmental effects, vegetative disturbance, and unbalanced nutrition play a significant role. Methodology: This study describes the association of obesity and insulin resistance with chronic inflammation, genetic, and epigenetic

    更新日期:2020-08-24
  • Recent Advances in Curcumin Treated Non-Small Cell Lung Cancers: An Impetus of Pleiotropic Traits and Nanocarrier Aided Delivery.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-24
    Parth Malik,John R Hoidal,Tapan K Mukherjee

    Characterized with abysmal 18% five year survival chances, non-small cell lung cancers (NSCLCs) claim more than half of their sufferers within the first year of being diagnosed. Advances in biomedical engineering and molecular characterization have reduced the NSCLC diagnosis via timid screening of altered gene expressions and impaired cellular responses. While targeted chemotherapy remains major option

    更新日期:2020-08-24
  • The emerging role of COX-2, 15-LOX, and PPARγ in metabolic diseases and cancer: An introduction to novel multi-target directed ligands (MTDLs).
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-20
    Rana A Alaaeddine,Perihan A Elzahhar,Ibrahim AlZaim,Wassim Abou-Kheir,Ahmed S F Belal,Ahmed F El-Yazbi

    Emerging evidence supports an intertwining framework for the involvement of different inflammatory pathways in a common pathological background for a number of disorders. Of importance are pathways involving arachidonic acid metabolism by cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX). Both enzyme activities and their products are implicated in a range of pathophysiological processes encompassing

    更新日期:2020-08-20
  • Role of Atypical Chemokines and Chemokine Receptors Pathways In the Pathogenesis of COPD
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-19
    Francesco Nucera,Federica Lo Bello,Sj S Shen,Paolo Ruggeri,Irene Coppolino,Antonino Di Stefano,Cristiana Stellato,Vincenzo Casolaro,Phil M Hansbro,Ian M Adcock,Gaetano Caramori

    Chronic obstructive pulmonary disease (COPD) represents a heightened inflammatory response in the lung resulting generally from tobacco smoking-induced recruitment and activation of inflammatory cells and/or activation of lower airway structural cells. Several mediators can modulate activation and recruitment of these cells, particularly those belonging to the chemokines (conventional and atypical)

    更新日期:2020-08-19
  • Perspectives in breast and ovarian cancer chemotherapy by nanomedicine approach: nanoformulations in clinical research.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-19
    Cristina Martín-Sabroso,Ana Isabel Fraguas-Sánchez,Rafaela Raposo-González,Ana Isabel TorresSuárez

    Breast and ovarian carcinomas represent major health problems in women worldwide. Chemotherapy constitutes a main treatment strategy, and the use of nanocarriers a good tool to improve it. Several nanoformulations have already been approved, and others are under clinical trials for the treatment of both types of cancers. OBJECTIVE This review focuses on the analysis of the nanoformulations that are

    更新日期:2020-08-19
  • Pieces of the complex puzzle of cancer cell energy metabolism: an overview of energy metabolism and alternatives for targeted cancer therapy.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-19
    Zeinab Ghasemishahrestani,Larissa Maura Melo Mattos,Tatiana Martins Tilli,André Souza Dos Santos,Marcos Dias Pereira

    Over the past decades, several advances in cancer cell biology have led to relevant details about a phenomenon called "Warburg effect". Currently, it has been accepted that Warburg effect is not anymore compatible with all cancer cells, and thus the process of aerobic glycolysis is now challenged by the knowledge of a large number of cells presenting mitochondrial function. The energy metabolism of

    更新日期:2020-08-19
  • Nerve Growth Factor, Stress and Diseases.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-18
    Flavio Maria Ceci,Giampiero Ferraguti,Carla Petrella,Antonio Greco,Paola Tirassa,Angela Iannitelli,Massimo Ralli,Mario Vitali,Mauro Ceccanti,George N Chaldakov,Paolo Versacci,Marco Fiore

    Stress is a constant threat for homeostasis and is represented by different extrinsic and intrinsic stimuli (stressors, Hans Selye's 'noxious agents'), such as aggressive behavior, fear, diseases, physical activity, drugs, surgical injury, and environmental and physiological changes. Our organism responds to stress activating the adaptive stress system to activate compensatory responses for restoring

    更新日期:2020-08-18
  • Drug Repurposing: Promises of Edaravone Target Drug in Traumatic Brain Injury.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-12
    Zaynab Shakkour,Hawraa Issa,Helene Ismail,Ohanes Ashekyan,Karl John Habashy,Leila Nasrallah,Hussam Jourdi,Eva Hamade,Stefania Mondello,Mirna Sabra,Kazem Zibara,Firas Kobeissy

    Edaravone is a potent free-radical scavenger that has been in the market for more than 30 years. It was originally developed in Japan to treat strokes and has been used there since 2001. Aside from its anti-oxidative effects, edaravone demonstrated beneficial effects on pro-inflammatory responses, nitric oxide production, and apoptotic cell death. Interestingly, edaravone has shown neuroprotective

    更新日期:2020-08-12
  • Drug Repurposing: A Strategy for Discovering Inhibitors against Emerging Viral Infections.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-12
    Igor José Dos Santos Nascimento,Thiago Mendonça de Aquino,Edeildo Ferreira da Silva-Júnior

    BACKGROUND Viral diseases are responsible for several deaths around the world. Over the past few years, the world has seen several outbreaks caused by viral diseases that for a long time seemed to possess no risk. These are diseases that have been forgotten for a long time and, until nowadays, there are no approved drugs or vaccines, leading the pharmaceutical industry and several research groups to

    更新日期:2020-08-12
  • Current trends on repurposing and pharmacological enhancement of andrographolide.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-10
    Xuan Ren,Wenzhou Xu,Jiao Sun,Biao Dong,Hussein Awala,Lin Wang

    Andrographolide, the main bioactive component separated from Andrographis paniculata in 1951, have been scrutinized with modern drug discovery approach for anti-inflammatory properties since 1984. Identifying new uses for existing drugs can be facilitated by evidence linking them to known or yet undiscovered drug targets and human disease states to develop new therapeutic indications. Afterwards, a

    更新日期:2020-08-10
  • Current Status of SUMOylation Inhibitors.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-08-10
    Christopher M Brackett,Brian S J Blagg

    SUMOylation has emerged as an important post-translational modification that involves the covalent attachment of the Small Ubiquitin-like Modifier (SUMO) polypeptide to a lysine residue of a target protein. The enzymatic pathway of SUMOylation is very similar to ubiquitinylation and involves an activating enzyme, a conjugating enzyme, ligases and deconjugating enzymes. SUMOylation modulates the function

    更新日期:2020-08-10
  • Chitosan-Nanocellulose Composites for Regenerative Medicine Applications.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-07-31
    Avik Khan,Baobin Wang,Yonghao Ni

    Regenerative medicine represents an emerging multidisciplinary field that brings together engineering methods and complexity of life sciences into a unified fundamental understanding of structure-property relationship in micro/nano environment to develop the next generation of scaffolds and hydrogels to restore or improve tissue functions. Chitosan has several unique physico-chemical properties that

    更新日期:2020-08-06
  • Cellulose-based Biosensor for Bio-molecules Detection in Medical Diagnosis: A Mini-Review.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-07-31
    Minmin Chang,Tao Song,Xinxin Liu,Qixuan Lin,Bei He,Junli Ren

    Background: Biosensors are widely applied for the detection of bio-molecules in blood glucose , cholesterol, and gene. Cellulose as the most dominating natural polymer has attracted more and more interest, especially in the field of medicine such as advanced medical diagnosis. Cellulose could endow biosensors with improved biocompatibility, biodegradability and nontoxicity, which could help in medical

    更新日期:2020-08-06
  • Strategies for the Biosynthesis of Pharmaceuticals and Nutraceuticals in Microbes from Renewable Feedstock.
    Curr. Med. Chem. (IF 4.184) Pub Date : 2020-07-31
    Congqiang Zhang,Heng-Phon Too

    Backgrounds: Abundant and renewable biomaterials serve as ideal substrates for the sustainable production of various chemicals, including natural products (e.g., pharmaceuticals and nutraceuticals). For decades, researchers have been focusing on how to engineer microorganisms and developing effective fermentation processes to overproduce these molecules from biomaterials. Despite many laboratory achievements

    更新日期:2020-08-06
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