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Renoprotective Effects of Cinnamon Oil Against APAP-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis and Inflammation in Rats Saudi Pharm. J. (IF 2.879) Pub Date : 2021-01-23 Saeed Alshahrani; Mohammad Ashafaq; Sohail Hussain; Manal Mohammed; Muhammad Sultan; Abdulmajeed M. Jali; Rahimullah Siddiqui; Fakhrul Islam
Acetaminophen (APAP) is used as a primary medication in relieving moderate pain and fever. However, APAP is associated with toxic effects in renal tissue that appear because of its free radicals property. The principle goal of the present work is to assess the kidney damage by APAP and its restore antioxidative property of cinnamon oil (CO). Animals were distributed into six animals each in six groups
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The influence of demographics and education level on influenza vaccine awareness and hesitancy among adults in Saudi Arabia Saudi Pharm. J. (IF 2.879) Pub Date : 2021-01-16 Abdullah A Alzeer; Lina A. Alfantoukh; Abdulrahman Theneyan; Fawaz Bin Eid; Thamer A Almangour; Abdullah K. Alshememry; Abdulaziz M. Alhossan
Objective To understand the influence of demographics and education levels on awareness levels, and on the prevalence of hesitancy to receive the influenza vaccine among adult patients at King Saud University Medical City (KSUMC). Method: A cross- sectional study in the outpatient pharmacy area at KSUMC was conducted. Data was collected from January 1 to January 31, 2020. A total of 318 random adult
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Evaluating the Frequency, Consumers’ Motivation and Perception of Online Medicinal, Herbal, and Health Products Purchase Safety in Saudi Arabia Saudi Pharm. J. (IF 2.879) Pub Date : 2021-01-11 Monira Alwhaibi; Wesam M Asser; Noha Alaloola; Nouf Alsalem; Aliyah Almomen; Tariq M. Alhawassi
Objectives Purchasing medicinal products from the internet has become more popular in the last three decades. Understanding consumers’ use and perception of the safety of medicinal products obtained online is essential. Therefore, this study aims to evaluate the extent of medicines purchased from the internet in Saudi Arabia, types of products, sources of information, the satisfaction, the motivational
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A Review on Extraction Techniques and Therapeutic Value of Polar Bioactives from Asian Medicinal Herbs: Case Study on Orthosiphon aristatus, Eurycoma longifolia and Andrographis paniculata Saudi Pharm. J. (IF 2.879) Pub Date : 2021-01-07 Nur Amanina Abd Aziz; Rosnani Hasham; Mohamad Roji Sarmidi; Siti Hasyimah Suhaimi; Mohamad Khairul Hafiz Idris
Medicinal plants have gained much interest in the prevention and treatment of common human disease such as cold and fever, hypertension and postpartum. Bioactive compounds from medicinal plants were synthesised using effective extraction methods which have important roles in the pharmaceutical product development. Orthosiphon aristatus (OA), Eurycoma longifolia (EL) and Andrographis paniculata (AP)
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Pharmacists’ satisfaction with their involvement in the management of COVID-19 patients in Saudi Arabia Saudi Pharm. J. (IF 2.879) Pub Date : 2021-01-07 Abdullah Assiri; Mir Javid Iqbal; Jawaher Gramish; Ahmed Assiri; Abdulkarim Meraya; Abdulaziz Alhossan; Moteb Khobrani
Introduction The Coronavirus Disease 2019 (COVID-19) is a public health emergency and during this unprecedented situation, health care providers across the globe are at the frontline in the fight against this disease. Countries that have been severely hit by the pandemic are using pharmacists to help triage patients. In order to ensure the continuity of these services, it is of paramount importance
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Oral medications administration through enteral feeding tube: Clinical pharmacist-led educational intervention to improve knowledge of Intensive care units’ nurses at Jordan university hospital Saudi Pharm. J. (IF 2.879) Pub Date : 2021-01-07 N. Abu Hdaib; A. Albsoul-Younes; M. Wazaify
Introduction Medication administration through enteral feeding tubes is a practice that is commonly encountered in hospital settings, particularly in critically ill patients. This study aims to evaluate the knowledge of intensive care unit nurses regarding enteral medication administration and evaluate the effect of an educational intervention led by a clinical pharmacist that would improve nurses’
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Immune System Response during Viral Infections: Immunomodulators, Cytokine Storm (CS) and Immunotherapeutics in COVID-19 Saudi Pharm. J. (IF 2.879) Pub Date : 2021-01-07 Faheem Hyder Pottoo; Tareq Abu-Izneid; Abdallah Mohammed Sudqi; Md. Noushad Javed; Noora AlHajri; Amar M. Hamrouni
Coronaviruses are non-segmented, single stranded positive-sense RNA (+ssRNA). To date, 06 human coronaviruses (HCoVs) are reported; α-CoVs (HCoVs-NL63 and HCoVs-229E) and β-CoVs (HCoVs-OC43, HCoVs-HKU1, SARS-CoV, MERS-CoV). While, novel coronavirus (SARS-CoV-2) is the most recent member. SARS-CoV-2 is 82% similar to SARS–COV-1. The compelling evidences that link the progression of viral infection of
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A Novel Perspective Approach to Explore Pros and Cons of Face Mask in Prevention the Spread of SARS-CoV-2 and other pathogens Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-31 Md Faruque Ahmad
Corona virus disease 2019 (COVID-19) outbreak has become a severe community health threat across the world. Covid-19 is a major illness, presently there is no as such any medicine and vaccine those can claim for complete treatment. It is spreading particularly in a feeble immune people and casualties are expanding abruptly and put the health system under strain. Among the strategic measures face mask
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Knowledge, perception, and confidence of hospital pharmacists toward pharmacogenetics in Jeddah, Kingdom of Saudi Arabia Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-30 Amina M. Bagher; Thikryat Neamatallah; Ghadeer Balto; Lina Almikhy; Sara S. Almutairi; Mohammed O. Abushal; Khlood Baghlaf; Sara M. Bagher
Background Integrating pharmacogenetics (PGx) testing into clinical practice leads to personalized medicine, which improves treatments’ efficacy and safety. Successful implementation of such a service requires sufficient knowledge, perception, and self-confidence among healthcare providers, especially pharmacists. Objectives To evaluate governmental hospital pharmacists’ knowledge, perception, and
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Targeted drug delivery of Methotrexate in situ gels for the treatment of Rheumatoid Arthritis Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-22 Madhugiri Prakash Venkatesh; Tegginmat Pramod Kumar; Deeksha Ramananda Pai
Rheumatoid arthritis (RA) is considered a debilitating disease that increases the risk of significant morbidity and premature mortality. To circumvent drug-related toxicity and ineffectiveness of anti-inflammatory drugs, there is a significant need for an advanced delivery system that increases bioavailability. The feasibility of in situ gel of methotrexate sodium (MTS) as an effective management for
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Antibacterial effects of antibiotics and cell-free preparations of probiotics against Staphylococcus aureus and Staphylococcus epidermidis associated with conjunctivitis Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-22 Sara Mohamed; Mohamed N. Elmohamady; Sohier Abdelrahman; Mahmoud M. Amer; Ahmed G. Abdelhamid
Conjunctivitis, caused by bacterial infections, represents health concern and diagnosis of the disease is pivotal for the proper selection of the treatment. The main causes of bacterial conjunctivitis vary in different countries. The current study investigated the common bacterial causes of bacterial conjunctivitis from eye clinics' attendants and evaluated the effectiveness of different therapeutic
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Evaluation of neurobiological and antioxidant effects of novel melatonin analogs in mice Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-21 Jana Tchekalarova; Natasha Ivanova; Zlatina Nenchovska; Rumiana Tzoneva; Tzveta Stoyanova; Veselina Uzunova; Slavina Surcheva; Alex Tzonev; Violina T. Angelova; Pavlina Andreeva-Gateva
Based on the pharmacophore model of melatonin (MT1) receptor, we recently synthesized a series of indole derivatives that showed anticonvulsant activity with low neurotoxicity and hepatotoxicity in rodents. In the present study, the three most potent C3-modified derivatives with hydrazine structure 3c, 3e, and 3f, with 2-chlorophenyl, 2-furyl, and 2-thienyl fragments, respectively, were selected, and
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Identification of potential inhibitors of Zika virus NS5 RNA-dependent RNA polymerase through virtual screening and molecular dynamic simulations Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-21 Noreen; Roshan Ali; Syed Lal Badshah; Muhammad Faheem; Sumra Wajid Abbasi; Riaz Ullah; Ahmed Bari; Syed Babar Jamal; Hafiz Majid Mahmood; Adnan Haider; Sajjad Haider
Zika virus (ZIKV) is one of the mosquito borne flavivirus with several outbreaks in past few years in tropical and subtropical regions. The non-structural proteins of flaviviruses are suitable active targets for inhibitory drugs due to their role in pathogenicity. In ZIKV, the non-structural protein 5 (NS5) RNA-Dependent RNA polymerase replicates its genome. Here we have performed virtual screening
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The impact of different extracts of six Lamiaceae species on deleterious effects of oxidative stress assessed in acellular, prokaryotic and eukaryotic models in vitro Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-24 Mariana M. Oalđe; Stoimir M. Kolarević; Jelena C. Živković; Branka S. Vuković-Gačić; Jovana M. Jovanović Marić; Margareta J. Kračun Kolarević; Jelena Z. Đorđević; Ana Z. Alimpić Aradski; Petar D. Marin; Katarina P. Šavikin; Sonja N. Duletić-Laušević
The main objective of this research was to evaluate the impact of methanolic, ethanolic and aqueous extracts of Origanum majorana L., Origanum vulgare L., Teucrium chamaedrys L., Teucrium montanum L., Thymus serpyllum L. and Thymus vulgaris L. (Lamiaceae) on the effects of free radicals using different model systems. The extracts were characterized on the basis of the contents of total phenolics, phenolic
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Differential modulation of Ahr and Arid5a: A promising therapeutic strategy for autoimmune encephalomyelitis Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-28 Abdullah Alzahrani; Hamza Hanieh
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Mannose receptor targeted bioadhesive chitosan nanoparticles of clofazimine for effective therapy of tuberculosis Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-24 Datta Maroti Pawde; Matte Kasi Viswanadh; Abhishesh Kumar Mehata; Roshan Sonkar; Narendra; Suruchi Poddar; Ankita Sanjay Burande; Abhishek Jha; Kiran Yellappa Vajanthri; Sanjeev Kumar Mahto; V.N. Azger Dustakeer; Madaswamy S. Muthu
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Pharmaceutical disposal facilitates the mobilization of resistance determinants among microbiota of polluted environment Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-28 Mudsser Azam; Vijay Kumar; Kehkashan Siddiqui; Arif Tasleem Jan; Jamal S.M. Sabir; Irfan A. Rather; Suriya Rehman; Qazi Mohd Rizwanul Haq
The emergence of resistance on exposure to pharmaceuticals among microorganisms has raised serious concern in the therapeutic approach against infectious diseases. Effluents discharge from hospitals, industries, and urban settlements containing pharmaceuticals and other toxic compounds into the aquatic ecosystem selects bacterial population against them; thereby promotes acquisition and dissemination
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Assessment of beverage consumption by young adults in Saudi Arabia Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-22 Md. Ashraful Islam; Aseel Fuad Al-karasneh; Ahmed Bin Hussain; Ali Muhanna; Taher Albu-hulayqah; Atta Abbas Naqvi; Muhammad Shahid Iqbal; Maryam Farooqui; Mahmoud E. Elrggal; Mansour Adam Mahmoud; Abdul Haseeb
Objective The primary objective was to assess beverage consumption pattern and calorie intake among undergraduate students on weekly and daily basis. Secondary objectives were to determine the relationship between demographic variables and beverage intake, assess mean differences in calorie intake between students’ groups and, report the predictors of beverage consumption. Methods A cross-sectional
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Perceptions regarding antimicrobial use and resistance among adult hospital patients in Saudi Arabian Ministry of Health (MOH) hospitals Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-29 Saleh Alghamdi; Ilhem Berrou; Zoe Aslanpour; Eshtyag Bajnaid; Abdulhakim Alzahrani; Nada Atef Shebl
Background Education, a key strategy within antimicrobial stewardship programmes (ASPs), has been mainly directed towards healthcare professionals and prescribers more than hospitalised patients. Aim To examine patients’ knowledge and perceptions of antibiotic use and resistance, while evaluating the institutional role of patient education on antibiotic use in two Saudi Arabian hospitals, one with
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Pulmonary route of administration is instrumental in developing therapeutic interventions against respiratory diseases Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-04 Xue Jin; Ling Song; Chao-Chao Ma; Yan-Chun Zhang; Shui Yu
Pulmonary route of drug delivery has drawn significant attention due to the limitations associated with conventional routes and available treatment options. Drugs administered through pulmonary route has been an important research area that focuses on to developing effective therapeutic interventions for asthma, chronic obstructive pulmonary disease, tuberculosis, lung cancer etc. The intravenous route
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Prevalence of post-traumatic stress disorder during the COVID-19 pandemic in Saudi Arabia Saudi Pharm. J. (IF 2.879) Pub Date : 2020-10-30 Fahad S. Alshehri; Yasser Alatawi; Badrah S. Alghamdi; Abdullah A. Alhifany; Adnan Alharbi
Background The coronavirus diseases of 2019 (COVID-19) pandemic was classified as one of the worst pandemics in the 21st century. Its rapid transmission, unpredicted mortality rate, and the uncertainty surrounding its transmission method have evoked additional fear and anxiety. Nonetheless, to the best of our knowledge, no prior study has explored PTSD prevalence three months after the start of the
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Categorizing and understanding medication errors in hospital pharmacy in relation to human factors Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-05 Reham Faraj Al-Ahmadi; Lobna Al-Juffali; Sulafah Al-Shanawani; Sheraz Ali
Background Medication errors (MEs) in hospital settings are attributed to various factors including the human factors. Human factors researches are aiming to implement the knowledge regarding human nature and their interaction with surrounding equipment and environment to design efficient and safe systems. Human Factors Frameworks (HFF) developed awareness regarding main system's components that influence
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A review on genus Millettia: Traditional uses, phytochemicals and pharmacological activities Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-05 Rasmita Jena; Diptirani Rath; Sudhanshu Sekhar Rout; Durga Madhab Kar
The genus Millettia belongs to Fabaceae includes 200 species which are distributed in tropical and subtropical regions of the world. Plants belong to this genus are used as folkloric medicine, for the treatment of different ailments like in wound healing, boil, sores, skin diseases, snake bite, muscle aches, pains, rheumatic arthritis, and gynaecological diseases. The aim of the review is to provide
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Hydrogel-based matrices for controlled drug delivery of etamsylate: Prediction of in-vivo plasma profiles Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-06 Soha M. El-Masry; Sally A. Helmy
Objectives To design oral controlled release (CR) hydrogel matrix tablets of etamsylate using various hydrophilic polymers. Additionally, to predict plasma concentration-time profiles of etamsylate released from different CR matrices. Methods Characterization of the in-vitro release rate was performed by various model dependent and model independent approaches. A simple numerical convolution strategy
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Application of quercetin flavonoid based hybrid nanocomposites: A review Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-06 Biswajit Parhi; Debasrita Bharatiya; Sarat K Swain
Natural bioflavonoids are an essential component of dietary supplements possessing antimicrobial properties. Many of the bioflavonoids have resulted in positive antitumor, anticancer, antibacterial, antifungal, anti-inflammatory properties, but the efficacy remains low due to toxicity at the molecular level whereas antiviral property limits to negative. The synergistic link between nanoscience and
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Developing a framework regarding a complex risk based methodology in the evaluation of hazards associated with medicinal products sourced via the internet Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-06 Róbert György Vida; Sára Merczel; Eszter Jáhn; András Fittler
Today, the increasing number of illicit internet pharmacies is a global phenomenon, however, the size of the online pharmaceutical market is still relatively unknown and the dubious quality of products is questionable and warrants investigation. Descriptive data from this black market channel are derived from studies analyzing the online availability of different medications procured over the internet
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Current COVID-19 vaccine candidates: Implications in the Saudi population Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-10 AlAnoud TofailAhmed Raja; Aws Alshamsan; Ahmed Al-jedai
Aim The purpose of this review is to discuss the current status of local and international efforts undergoing clinical trials aiming at developing a Coronavirus Disease-2019 (COVID-19) vaccine, and to highlight the anticipated challenges of this vaccine globally and in Saudi Arabia. Present Findings COVID-19 vaccine development efforts started in early January 2020 when Chinese scientists shared the
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Sex differences in pregabalin-seeking like behavior in a conditioned place preference paradigm Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-09 Hashem O. Alsaab; Ebtehal Altowairqi; Nada Alzahrani; Reem Alzahrani; Fahad S. Alshehri; Atiah H. Almalki; Walaa F. Alsanie; Ahmed Gaber; Turki Alkhalifa; Ahmad Almalki; Zahoor A. Shah; Yusuf S. Althobaiti
Substance abuse is a chronic, relapsing disorder characterized by compulsive drug use regardless of negative consequences. Incremental increases in pregabalin abuse have been observed in Saudi Arabia and throughout the world. In previous studies, the potential for pregabalin abuse with escalating doses of the drug (30, 60, 90, and 120 mg/kg) were investigated in male mice. Notably, researchers have
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Impact of clinical pharmacist-led diabetes management clinic on health outcomes at an academic hospital in Riyadh, Saudi Arabia: A prospective cohort study Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-11 Bashayr Alsuwayni; Abdulaziz Alhossan
Background Diabetes prevalence is estimated to reach 20.6% by 2030. Studies have illustrated main reasons for uncontrolled patients and concluded: low level of awareness, limited access to healthcare providers, and lack of cooperation between different disciplines. The role of pharmacists has been proven to improve patient-related outcomes, including an improvement in HgA1C readings between 0.54% and
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Chloroquine, hydroxychloroquine, and COVID-19: Systematic review and narrative synthesis of efficacy and safety Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-13 Michael Takla; Kamalan Jeevaratnam
The COVID-19 pandemic has required clinicians to urgently identify new treatment options or the re-purposing of existing drugs. Of particular interest are chloroquine (CQ) and hydroxychloroquine (HCQ). The aims of this systematic review are to systematically identify and collate 24 studies describing the use of CQ and HCQ in human clinical trials and to provide a detailed synthesis of evidence of its
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Pharmacological and computer-aided studies provide new insights into Millettia peguensis Ali (Fabaceae) Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-17 Safaet Alam; Nazim Uddin Emon; Saimon Shahriar; Fahmida Tasnim Richi; Mohammad Rashedul Haque; Mohammad Nazmul Islam; Shahenur Alam Sakib; Amlan Ganguly
Millettia peguensis, popular for its ethnopharmacological uses, was employed to evaluate its different pharmacological properties in this study. The analgesic studies of the plant have been performed by acetic acid-induced writhing and formalin-induced licking tests respectively, whereas the antidiarrheal experiment was done by castor oil-induced diarrheal test. Besides, antioxidant, cytotoxic, antimicrobial
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Comparative efficacy of Gum Arabic (Acacia senegal) and Tribulus terrestris on male fertility Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-18 Omaima Nasir; Nada Alqadri; Salma Elsayed; Omaima Ahmed; S.H. Alotaibi; Roua Baty; Hiba Omer; Suzan A. Abushal; Anja T Umbach
In this study the effect of Gum arabic (Acacia Senegal) was systemically targeted at male fertility with two experiments, the first comparing the effectiveness of Gum arabic (GA) and Tribulus terrestris (TT). For the first experiment, 27 adult mice Balb / c (18 females, 9 males) were divided into 3 in each group, one male and two females, group one had the usual tap water as power, group two had 5%
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Pharmacists’ roles in emergency and disasters: COVID-19 as an example Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-21 Wejdan Aburas; Thamir M. Alshammari
Background Emergencies and disasters are major threats to health care systems. Coronavirus Disease 2019 (COVID-19) is at the center of a recent emergency situation that requires increased attention from health care professionals, including pharmacists. This study was aimed at providing an overview of pharmacists’ roles in disasters and formulating a definition of expected roles and tasks through which
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Development of spray-dried amorphous solid dispersions of tadalafil using glycyrrhizin for enhanced dissolution and aphrodisiac activity in male rats Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-21 Mohammed Muqtader Ahmed; Farhat Fatima; Mohd Abul Kalam; Aws Alshamsan; Gamal A. Soliman; Abdul Azim Shaikh; Saad M Alshahrani; Mohammed F. Aldawsari; Saurabh Bhatia; Md. Khalid Anwer
Tadalafil (TDL) is a phosphodiesterase-5 inhibitor (PDE5I), indicated for erectile dysfunction (ED). However, TDL exhibits poor aqueous solubility and dissolution rate, which may limit its application. This study aims to prepare amorphous solid dispersion (ASD) by spray-drying, using glycyrrhizin-a natural drug carrier. Particle and physicochemical characterizations were performed by particle size
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Improving the understanding of originator and biosimilar biologics among healthcare providers in Saudi Arabia Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-27 Mohammed A. Omair; Tariq Alhawassi; Munira Alwaihibi; Ghada Aldrees; Mahmoud Mosli; Wesam M. Asser; Maryam A. Alharaibi; Atheer T. Alotaibi; Doaa A. Bintaleb; Najah K. Alharbi; Ahmed Z. Alotaibi; Wajed A. Alshammari; Nouf Alanazi; Ali M. Asiri; Rana Almadany; Hanan Al Rayes; Turki Al-Thunian; Moureq Alotaibi; Abdulrazaq Al Jazaeri
The loss of patentability of many originator biologics has led to the rapid introduction of biosimilar agents. The anticipated economic benefit of introducing such agent has been accompanied by vagueness surrounding their biotechnology, approval requirements, positioning in treatment paradigms and potential for adverse events. The Second Symposium on Biologics and Biosimilars “Beyond Clinical Practice”
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Association between graduates' factors and success rate on the Saudi Pharmacist Licensure Examination: A single-Institution cross-sectional study Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-23 Abdullah A. Alhifany; Faisal A. Almalki; Yasser M. Alatawi; Linah A. Basindowh; Shefaa S. Almajnoni; Mahmoud E Elrggal; Amal F. Alotaibi; Safa S. Almarzoky Abuhussain; Thamer A. Almangour
Introduction The Saudi Pharmacists Licensure Examination’s (SPLE) initial results were revealed in February 2020, which showed enormous inconsistency with the passing rates. Hence, we aimed to investigate the predictors of pharmacy graduates’ success rate on the SPLE of a single-college in Saudi Arabia. Methods In a cross-sectional study of 2019-graduates, data were collected via-phone interviews and
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Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-26 Faisal Alsenani; Karnaker R. Tupally; Elvis T. Chua; Eladl Eltanahy; Hamed Alsufyani; Harendra S. Parekh; Peer M. Schenk
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Formulation and evaluation of Ocimum basilicum-based emulgel for wound healing using animal model Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-23 Barkat Ali Khan; Shafi Ullah; M.Khalid Khan; Sultan M Alshahrani; Valdir A Braga
The main aim of the topically applied drugs is to provide local drug contact to the skin and minimize general absorption of drugs. Ocimum basilicum (OB) is popular for folk medicines, having official acceptance in many countries. The aim of this study was to formulate and evaluate the efficacy of topical application of OB-based emulgel on wound healing in animal model. The prepared formulations (OB
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Developed simvastatin chitosan nanoparticles co-crosslinked with tripolyphosphate and chondroitin sulfate for ASGPR-mediated targeted HCC delivery with enhanced oral bioavailability Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-25 Tarek M. Faris; Gamaleldin I. Harisa; Fars K. Alanazi; Ahmed M. Samy; Fahd A. Nasr
Simvastatin (SV) repurposing has emerged as an alternative approach for the treatment of cancer. In this study, SV chitosan nanoparticles co-crosslinked with tripolyphosphate and chondroitin sulfate (SVCSChSNPs) were developed in order to maximize SV therapeutic efficiency. The hepatic targeting was realized using N-acetylgalactosamine (GalNAc) residues of ChS, which can be identified by the ASGPR
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Feeling of stigmatization and satisfaction with life among Arabic psoriatic patients Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-25 Moetaza M. Soliman
Background Satisfaction and stigmatization are experienced differently in different cultural contests, especially, in patients with dermatological diseases affecting visible body parts. Reports in Arabic countries remain rare and very appealing in a multicultural population. Aims To evaluate feeling of stigmatization and satisfaction with life in Arabic patients with psoriasis and identify predictors
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COVID-19 pandemic: Mechanistic approaches and gender vulnerabilities Saudi Pharm. J. (IF 2.879) Pub Date : 2020-11-25 Luqman Khan; Nisar Ul Khaliq; Asad Ullah; Naseem Rafiq; Mujib Ullah
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a highly pathogenic virus that causes coronavirus-19 disease (COVID-19), a severe respiratory damaging syndrome with serious health complications worldwide. SARS-CoV-2 was unfamilar before the epidemic started in Wuhan, China, in December 2019. COVID-19 is currently a pandemic influencing several countries worldwide. One of the mysteries
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Dental Practitioners' and Students' knowledge of Medication related Osteonecrosis of the Jaw Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-29 Mandlin Abdulaziz Almousa; Ghadah Khalid Alharbi; Amerah Saeed Alqahtani; Yusra Chachar; Lubna Alkadi; Ali Aboalela
Background Medication-related osteonecrosis of the jaw (MRONJ) is a complication affecting patients who are being treated with antiresorptive or antiangiogenic medication. These patients require meticulous treatment planning and management strategies. This research aimed to assess the knowledge of dental practitioners and students in their professional years regarding MRONJ. Methods A cross-sectional
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Ethnopharmacological study of herbal remedies used for the management of thyroid disorders in Algeria Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-29 Khaled Taïbi; Leila Ait Abderrahim; Fatima Helal; Khalida Hadji
Traditional medicine is gaining an increasing importance in diseases management. Besides, thyroid disease is one of the common endocrine disorders spreading at high frequency worldwide. The present work is an ethnopharmacological study aiming to identify, document and analyze aromatic and medicinal plants used in Algerian traditional medicines for thyroid disorders management. Semi-structured interviews
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Evolving to Objective Structured Clinical Exams (OSCE): Transitional experience in an undergraduate pharmacy program in Kuwait Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-29 Asmaa Al-Haqan; Dalal Al-Taweel; Samuel Koshy; Sarah Alghanem
Background Objective Structured Clinical Exams (OSCEs) can assess professional competencies in a structured manner and facilitate objective evaluation of clinical performance. With limited data from the Eastern Mediterranean region, this study aims to describe the development, implementation, and evaluation of OSCEs for final year pharmacy students in Kuwait. The study also aims to compare students'
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Induction of Cell Death and Modulation of Annexin A1 by Phytoestrogens in Human Leukemic Cell Lines Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-22 Affidah Sabran; Endang Kumolosasi; Ibrahim Jantan; Jamia Azdina Jamal; Norazrina Azmi; Malina Jasamai
Background Phytoestrogens are polyphenolic plant compounds which are structurally similar to the endogenous mammalian estrogen, 17β-estradiol. Annexin A1 (ANXA1) is an endogenous protein which inhibits cyclo-oxygenase 2 (COX-2) and phospholipase A2, signal transduction, DNA replication, cell transformation, and mediation of apoptosis. Objective This study aimed to determine the effects of selected
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Assessing Factors Influencing Pharmacy Interns Career Choices in Saudi Arabia Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-22 Douha Bannan; Mohannad Alshibani; Samah Alshehri; Ahmed Aljabri; Hussam
Background The number of students enrolled in the colleges of pharmacy in Saudi Arabia is high, and the number of pharmacy graduates expected to join the workforce in the coming years is expected to grow. There are limited number of studies that assess factors influencing pharmacy students’ career choices in Saudi Arabia in the literature. The aim of this study was to assess the factors that influence
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What just happened? Impact of on-campus activities suspension on pharmacy education during COVID-19 lockdown – A students’ perspective Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-21 Majid Ali; Moayad Allihyani; Akrm Abdulaziz; Safwan Alansari; Sultan Faqeh; Ahmad Kurdi; Abdulrahman Alhajjaji
Introduction COVID-19 pandemic induced lockdown, suspending all on-campus educational activities in the Kingdom of Saudi Arabia (KSA), compelling to continue the education online. We explored pharmacy students’ perspective on its impact on their learning. Methods A Twitter chat was organized on three consecutive days, after final examinations, inviting all pharmacy students in KSA to participate. Day
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Biochemical and histological effects of five weeks ingestion of Zamzam water on the liver and kidneys of Wistar rats Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-21 Huda A. Al Doghaither; Razan M. Al-Sohaibani; Ulfat M. Omar; Hassan A. Alharbi
Zamzam water is a natural alkaline water which has become alkaline as a result of the natural environment. It comes from what is considered as one of the oldest springs in the world. The water contains high concentrations of alkaline minerals as well as trace and heavy metals. The aim of the current study is to evaluate the effects of five weeks ingestion of Zamzam water on the liver and kidney functions
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Self-medication practices during the COVID-19 pandemic among the adult population in Peru: a cross-sectional survey Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-15 Jean Franco Quispe-Cañari; Evelyn Fidel-Rosales; Diego Manrique; Jesús Mascaró-Zan; Katia Medalith Huamán-Castillón; Scherlli E. Chamorro–Espinoza; Humberto Garayar–Peceros; Vania L. Ponce–López; Jhesly Sifuentes-Rosales; Aldo Álvarez-Risco; Jaime A. Yáñez; Christian R. Mejia
Self-medication impacts both negatively and positively the health of people, which has become evident during the COVID-19 pandemic. The study aimed to assess the prevalence of self-medicated drugs used for respiratory symptoms, as COVID-19 preventive, for its symptoms or once tested positive. To determine the perception of symptom relief and demographic variables that promote self-medication in Peru
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Identification of Potential Therapeutic Target of Naringenin in Breast Cancer Stem Cells Inhibition by Bioinformatics and In Vitro Studies Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-15 Adam Hermawan; Muthi Ikawati; Riris Istighfari Jenie; Annisa Khumaira; Herwandhani Putri; Ika Putri Nurhayati; Sonia Meta Angraini; Haruma Anggraini Muflikhasari
Cancer therapy is a strategic measure in inhibiting breast cancer stem cell (BCSC) pathways. Naringenin, a citrus flavonoid, was found to increase breast cancer cells’ sensitivity to chemotherapeutic agents. Bioinformatics study and 3D tumorsphere in vitro modeling in breast cancer (mammosphere) were used in this study, which aims to explore the potential therapeutic targets of naringenin (PTTNs) in
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Fisetin Protects Against Streptozotocin-Induced Diabetic Cardiomyopathy in Rats by Suppressing Fatty Acid Oxidation and Inhibiting Protein Kinase R Saudi Pharm. J. (IF 2.879) Pub Date : 2020-12-14 Jozaa Z. ALTamimi; Mona N. BinMowyna; Nora A. AlFaris; Reham I. Alagal; Attalla F. El-kott; Ammar M. AL-Farga
This study examined if the Fisetin against streptozotocin-induced diabetic cardiomyopathy (DC) in rats involves regulating cardiac metabolism and suppressing protein kinase R (PKR). Male rats were divided (12/groups) as control (non-diabetic), control + Fisetin, T1DM, and T1DM + Fisetin. Fisetin was administered orally at a final dose of 2.5 mg/kg for 12 weeks. In T1DM1-induced rats, Fisetin prevented
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The potential of Atorvastatin for chronic lung diseases therapy Saudi Pharm. J. (IF 2.879) Pub Date : 2020-09-12 Alaa S. Tulbah
Atorvastatin (ATO) is of the statin class and is used as an orally administered lipid-lowering drug. ATO is a reversible synthetic competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase thus leading to a reduction in cholesterol synthesis. It has recently been demonstrated that ATO has different pharmacological actions, which are unrelated to its lipid-lowering effects and has
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Optimization and evaluation of venlafaxine hydrochloride fast dissolving oral films Saudi Pharm. J. (IF 2.879) Pub Date : 2020-09-12 Arwa Ibrahim Al-Mogherah; Mohamed Abbas Ibrahim; Maha Abdelazeem Hassan
Three factors, three levels (33) full factorial design was used to develop venlafaxine HCl fast dissolving oral films (FDOFs) to optimize the concentrations of the film forming polymer; hydroxypropyl methylcellulose HPMC (X1), superdisintegrant; sodium starch glycolate SSG, (X2) and glycerol as the film plasticizer (X3). Effects of the three factors on the disintegration time (Y1), swelling index (Y2)
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Siphonocholin isolated from red sea sponge Siphonochalina siphonella attenuates quorum sensing controlled virulence and biofilm formation Saudi Pharm. J. (IF 2.879) Pub Date : 2020-09-12 Perwez Alam; Ali S. Alqahtani; Fohad Mabood Husain; Md. Tabish Rehman; Mohamed F. Alajmi; Omar M. Noman; Ali A. El Gamal; Shaza M. Al-Massarani; Mohammad Shavez Khan
Increasing incidence of multi-drug resistant bacterial pathogens, especially in clinical settings, has been developed into a grave health situation. The drug resistance problem demands the necessity for alternative unique therapeutic policies. One such tactic is targeting the quorum sensing (QS) controlled virulence and biofilm production. In this study, we evaluated a marine steroid Siphonocholin
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Optimization of post-insertion method to conjugate Doxil with anti-CD133 monoclonal antibodies: Investigating the specific binding and cytotoxicity to colorectal cancer cells in vitro Saudi Pharm. J. (IF 2.879) Pub Date : 2020-09-12 Karim Dadashi Noshahr; Fahimeh Shamsi; Peter Valtchev; Parviz Kokhaei; Maral Hemati; Mohammad Reza Akbari Eidgahi; Ali Khaleghian
In this paper, Doxil coupled with anti-CD133 monoclonal antibodies made by either routine or optimized post-insertion technique, were compared with respect to their size, drug leakage, release pattern and the number of antibodies conjugated per single liposome. The results demonstrated that the number of antibodies conjugated per liposome in the optimized post-insertion technique was almost two times
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Community Pharmacy Services and Preparedness during COVID-19 Outbreak in Madinah, Saudi Arabia. Saudi Pharm. J. (IF 2.879) Pub Date : 2020-09-17 Hani M J Khojah
Background Wearing facial masks, hand hygiene, and social distancing are highly recommended preventive measures against COVID-19. Masks and disinfectants are usually sold in community pharmacies that are supposed to undertake extreme precautions to avoid cross infection among clients. It is also their responsibility to play a prominent role in educating the community regarding this outbreak. Objectives
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A possible interaction between linezolid and digoxin: A case report of therapeutic drug monitoring Saudi Pharm. J. (IF 2.879) Pub Date : 2020-09-14 Zhu Yulin; Kong Lingti; Gao Shan; Zhang Yong
Drug-drug interactions lead to altered clinical effects, including adverse reactions. Therapeutic drug monitoring of digoxin is necessary due to its narrow therapeutic range. Linezolid can cause variable exposures in patients hospitalized in the intensive care unit owing to its possibility of drug-drug interactions. We present a patient with pneumonia and heart failure who experienced a possible drug
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Household storage of pharmaceutical products in Saudi Arabia; A call for utilising smart packaging solutions Saudi Pharm. J. (IF 2.879) Pub Date : 2020-09-22 Abdulmalik Alqurshi
Background Limited information is known about the storage conditions of medicinal products post-dispensing in Saudi Arabia (SA). The particularly hot and humid climate in the region may lead to the loss of essential performance specifications. Objective To investigate the conditions in which medications are held after being dispensed, and up until administration by households in SA. In addition, storage
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Dual-action of thermoresponsive gels containing DsiRNA-loaded gold nanoparticles for diabetic wound therapy: Characterization, in vitro safety and healing efficacy Saudi Pharm. J. (IF 2.879) Pub Date : 2020-09-18 Ahmad Yasser Hamdi Nor Azlan; Haliza Katas; Nur Hamizah Habideen; Mohd Fauzi Mh Busra
Diabetic wounds are difficult to treat due to multiple causes, including reduced blood flow and bacterial infections. Reduced blood flow is associated with overexpression of prostaglandin transporter (PGT) gene, induced by hyperglycaemia which causing poor vascularization and healing of the wound. Recently, gold nanoparticles (AuNPs) have been biosynthesized using cold and hot sclerotium of Lignosus
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COVID-19 impact on pharmacy education in Saudi Arabia: Challenges and opportunities Saudi Pharm. J. (IF 2.879) Pub Date : 2020-09-24 Mansour Almetwazi; Nourh Alzoman; Shaza Al-Massarani; Aws Alshamsan
The first case of COVID-19 was announced at the end of year 2019, and later many cases were identified worldwide. In Saudi Arabia, the first case was announced on 2 March 2020. To prevent the spread of this pandemic disease, many precautionary actions were taken by Saudi government. One of these actions was closing public and private schools and universities and transfer the educational activities
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