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Trillin Protects Against Bleomycin-Induced Pulmonary Fibrosis via Suppressing Oxidative Stress and IL-1β/NLRP3 Inflammasome Positive Cycle Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-15 Xiangyun Li, Shanshan Wei, Sa Liu, Suifen Xie, Jiaqin Liu, Yuanying Yang, Ye Chen, BiKui Zhang, Wenqun Li, Fen Luo
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fibrotic interstitial lung disease. Trillin, an active saponin component isolated from Trillium tschonoskii Maxim, exhibits various pharmacological properties. This study aimed to investigate the preventive effects of Trillin on bleomycin (BLM)-induced IPF and elucidate its underlying mechanisms.MethodsBLM was administered
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Morphology and Cyto-Architecture of the Testis and Assessment of Selected Biochemical Parameters Associated with Male Fertility Following the Consumption of Tom Brown Weaning Diet in Albino Wistar Rats Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-15 Victor Kanu Uno, Justina Nwandimma Nwangwa, Ekementeabasi Aniebo Umoh, Atim-Ebim Michael Raymond, Joseph Okon Asuquo, Effiom-ekaha Otu Otu, Maxwell Inawerebua Beniangba
Objectives/BackgroundNatural products are preferred over synthetic drug as fertility enhancers as they are cost effective. Infertility among men of reproductive age keeps rising. Synthetic drugs ameliorate the problem but leave adverse side effects as men advance in age, hence the need for alternative medicine. Tom brown weaning diet is a processed cereal-based powdery blend which is cooked into a
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Tripterygium Glycosides in the Treatment of Asthma: Integrating Network Pharmacology, Molecular Docking and In Vitro Preliminary Pharmacological Evaluation Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-15 Shuhui Gao, Min Yan, Tianci Jiang, Jingyao Lian, Zhe Cheng, Huahui Zeng, Junwei Zhao
ObjectivesThe mechanism of tripterygium glycosides (TG) in the treatment of asthma was explored by utilizing network pharmacology, molecular docking, and in vitro preliminary pharmacological tests.MethodsAn analysis of the bioactive ingredients of TG was conducted using the Traditional Chinese Medicine Systems Pharmacology Database database or predicted by FAFdrugs4, with relevant targets gathered
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Uncovering the Nephroprotective Mechanism of Caffeic Acid in Renal Tubulointerstitial Fibrosis through Network Pharmacology Analysis Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-13 Wenbo Sun, Haojie Liu, Baoqiao Wu, Limiao Dai, Yan Ren, Danna Zheng
Background: Renal tubulointerstitial fibrosis (RTF) is a progressive kidney condition characterized by the formation of fibrotic tissue. Caffeic acid (CA), a key component of the medicinal plant Antirhea borbonica, shows promise as a potential treatment for renal fibrosis. Here, we investigated the nephroprotective effect of CA in RTF and its underlying mechanisms. Methods: RTF was induced in rats
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Integrated UHPLC-Q-Orbitrap-MS/MS Method and Network Pharmacology for Exploring the Active Components and Potential Mechanisms of Neuroprotective Effect of the n-Butanol Part of Mume Flos Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-10 Xue Wang, Hongsu Zhao, Mengying Wu, Yijie Gan, Shurong Zhang, Deling Wu, Jinmei Ou, Chuanshan Jin, Wei Zhang
Background: Mume Flos is a common Qi-regulating medication used in traditional Chinese medicine, modern study has discovered that Mume Flos and its components have neuroprotective properties. However, the effective components and molecular mechanisms of Mume Flos are still unclear. Methods: In this study, the current study chose Caenorhabditis elegans as a model to evaluate the anti-Alzheimer disease
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Mechanism for Huanglian Jiedu Decoction-Based Therapy for MAFLD Analyzed Through Network Pharmacology and Experimental Verification Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-08 Jixian Zheng, Anni Zheng, Sufei Song, Mengyu Lin, Tao Liu, Qiuling Xu
Objective: To analyze the mechanism of Huanglian Jiedu Decoction (HLJDD) in the treatment of metabolism-associated fatty liver disease (MAFLD). Methods: The main components, targets, and pathways for treating MAFLD of HLJDD were screened through network pharmacology and molecular docking validation was done; HLJDD was used to intervene MAFLD model of rat, the levels of ALT, AST, TC, TG, GLU, HDL, and
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Mechanism of Action of Yikun Yitong Ping-Containing Serum on Mast Cells and its Possible Involvement in Endometriosis-Related Dysmenorrhea Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-28 Fang Yang, Yonghui Yu, Hong Liu
BackgroundPreviously, we showed that Yikun Yitong Ping (YKYTP) can effectively and safely relieve endometriosis-related dysmenorrhea; however, the underlying mechanism remained unclear. This study aimed to assess the effects of YKYTP-containing serum on rat basophilic leukemia cell line, as mast cells (MCs) analog, and investigate the mechanisms by which YKYTP alleviates endometriosis-related dysmenorrhea
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Multifunctional Analysis of Banana Leaves Extracts for Dyeing Properties of Pima Cotton Fabric Using Different Mordants Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-26 Qurat ul Ain, Zill-i-Huma Nazli, Maryam Aslam, Imran Zafar, Hassan Imran Afridi, Ahsanullah Unar, Muhammad Jamshaid, Rizwan- ur-Rehman, Waseem Shoukat, Hanane Mouada, Fakhreldeen Dabiellil, Mohammed Bourhia, Abdulaziz Abdullah Alsahli
IntroductionNatural dyes have become very important for decades based on their extensive properties compared to synthetic dyes. Pima cotton was dyed with natural dyes derived from plants using mordants, a crucial step in modern industry.ObjectiveThis study explores the efficacy of banana leaf-extracted natural dyes with mordants in dyeing Pima cotton, examining color properties, chemical attributes
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Ethnomedicinal, Phytochemical, and Pharmacological Properties of Diospyros mollis Griff.: A Review Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-26 Tran Van Chen, Nguyen Trong Nghia, Le Van Nhat Truong, Nguyen Hoang Khanh Linh
Objective/BackgroundThe genus Diospyros L. (Ebenaceae) includes about 778 species worldwide, with over 500 of them known for their significant health benefits. Among them, Diospyros mollis Griff. has been used as a tonic and treatment for many diseases related to digestive disorders and intestinal parasites. Furthermore, the fruit has also been used for dyeing silk fabrics. The purpose of this comprehensive
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Isolation and Identification of Anti-Inflammatory Active Components from Asparagi Radix cochinchinensis Based on HPLC-CAD and UPLC-Q/TOF-MS Techniques Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-26 Yan Lei, Bing Wang, Guanglin Zhu, Guo Feng, Wei Li, Caiyao Han, Qian Qin, Xie-an Yu, Xueli Song, Zhengyan He, Ju Zhang, Hongmei Su, Wenjing Wang
Background: In the research of the pharmacological activity of modern Chinese medicine, a large number of traditional Chinese medicines show anti-inflammatory activity. Asparagi radix is one of the anti-inflammatory drugs. With the deepening of people's research on Asparagi radix, its anti-inflammatory pharmacological effects have been gradually explored, but its specific anti-inflammatory active ingredients
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Evaluation of Saudi Juniperus procera Extracts Cytotoxicity and Regulatory Mechanisms of Tumorigenesis Against Two Breast Cancer Cell Lines Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-23 Ateeq A. Al-Zahrani, Farag Ibraheem, Mohamed El-Hefny, Fardous El-Senduny
BackgroundBreast cancer poses a major threat to female health worldwide. One of the medicinal plants used in traditional Saudi medicine is the Juniperus procera (Arar) plant, which is used to cure various illnesses, including cancer.ObjectivesThe cytotoxic properties of Saudi J. procera extracts and their regulatory mechanisms against tumorigenesis in breast cancer were investigated.MethodsThe antioxidant
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Seasonal Variations in the Essential Oil Composition and Biological Activities of Wild Lavandula dentata L. Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-21 Amina Labhar, Yahya El-Mernissi, Naoufal Ahidar, Aziz Zouhri, Omar Benamari, Farhan Siddique, Maryam Bashir, Amin Salhi, Mhamed Ahari, Samir Ibenmoussa, Mohammed Bourhia, Ahmad Mohammad Salamatullah, Abdellah ELyoussfi, Hassan Amhamdi
Introduction: Lavandula dentata L. (LD) is a well-known aromatic and medicinal plant celebrated for its abundant essential oil (EO) with applications in aromatherapy, perfumery, and traditional medicine. The chemical composition and biological properties of LD EO can vary based on factors like harvesting period, and cultivation location. Methods: Gas chromatography–mass spectrometry was employed to
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Effects of Inhaled Linalool on the Autonomic Nervous System in Awake Mice Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-19 Tadaaki Satou, Momono Kamagata, Shinjiro Nakashima, Koushi Mori, Moeka Yoshinari
Objective/backgroundA previous study showed that geranium essential oil predominantly affects the parasympathetic nervous system. This article examined the effects on the autonomic nervous system of linalool, one of the main components of geranium essential oil.MethodsMice were placed on a narrow elevated open platform and pulse wave measurements were taken while they were awake, with behaviors restricted
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Study on the Chemical Composition and Blood-Entry Components of Nourishing Blood Diuretic Formula Based on Liquid Chromatography-Mass Spectrometry and Network Pharmacology Techniques Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-15 Si-Cheng Yang, Xia Lei, Si-Fang Xie, Ju Huang, Feng-Qin Yue, Si-Di Chen, Wei Peng, Heng Fan, Sen Li, Xue-Yun Duan, Wan-Jin Sun
Objective: Analyzing the chemical composition and blood-entry components of Nourishing Blood Diuretic Formula (NBDF) by Liquid Chromatography-Mass Spectrometry (LC-MS), and analyzing the mechanism of NBDF in the treatment of chronic renal failure by combining network pharmacology and molecular docking technology. Methods: The prototype components were obtained by LC-MS, and the targets of the prototype
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Essential Oils of Two Species of Zingiberaceae Family from Vietnam: Chemical Compositions and α-Glucosidase, α-Amylase Inhibitory Effects Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-14 Hieu Tran-Trung, Duc Giang Le, Van Trung Hoang, Danh C. Vu, Tran Dinh Thang, Hieu Nguyen-Ngoc, Chen Tran Van, Thanh Triet Nguyen, Nguyen Hoang Tuan, Trang H.D. Nguyen
The ginger family (Zingiberaceae) is one of the most diverse and abundant families in the plant kingdom in terms of number of species. In terms of chemistry, this is a family of plants containing much essential oil with mainly monoterpene and sesquiterpene derivatives, which has been widely used in medicine, food, and flavor industries. In our series of studies on ginger family plants, the two new
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The Dynamics of Bioactive Ingredients With Anti-Inflammatory and Anti-Breast Cancer Activity During Prunellae Spica Development Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-13 Zhimin Zhang, Qian Su, Yan Lin, Bohou Xia, Yamei Li, Jingchen Xie, Ping Wu, Duanfang Liao, Limei Lin
To investigate the scientific connotation of harvest period for Prunella vulgaris L. ( P vulgaris, known as Prunellae Spica), the triterpenoids and phenols of Prunellae Spica in developmental stages were quantified by high performance liquid chromatography, and the anti-inflammatory and anti-breast cancer properties of which were investigated. Furthermore, Grey correlation and Pearson correlation analysis
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Antibacterial Activity and Possibly Made of Action of Isoquinoline-3-Carboxylic Acid Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-09 Xu Zhiyuan, Ding Haixin, Fu Xin, Xu Yan, Zhu Fadi, Ye Huochun, Zhang Yuan Yuan, Guo Yongxia, Zhang Jing, Feng Gang
ObjectivesDue to the urgent need to develop innovative, environmentally sustainable bactericides, we use the natural product isoquinoline as a lead compound to discover highly active bactericides from isoquinoline derivatives.MethodsIn this paper, the antibacterial activity of 49 isoquinoline derivatives was evaluated against three plant bacteria in vitro.ResultsAmong all the derivatives, isoquinoline-3-carboxylic
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Curcumin Delivery Systems: How Far from Clinical Application in Tumor Therapy? Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-07 Yuanru Wang, Lubiao Liang, Yajin Zhao
Curcumin, a natural polyphenol compound found in turmeric, exhibits significant anti-cancer activity in preclinical studies. However, its clinical application is limited by poor bioavailability and low solubility in aqueous media. To overcome these challenges, various curcumin delivery systems (CDSs) have been developed to enhance the pharmacokinetics and pharmacodynamics of curcumin, aiming to improve
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Preparation, Characterization, and Sub-Chronic Toxicity of Carvacrol-Self-Nano-Emulsifying Drug Delivery System Towards Healthy Sprague Dawley Rats Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-07 Fenk Bakir Maarouf, Heshu Sulaiman Rahman
Background: Carvacrol (CAR) is the active component in essential oils (EOs) of many fragrant plants, including oregano and thyme; however, its high toxicity restricts its usage in biomedical fields, and the self-nano-emulsifying drug delivery system (SNEDDS) was suggested to overcome this issue. Objective: To prepare and characterize the CAR-loaded SNEDDS and to assess its toxicity profile towards
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Momordin Ic Inhibits the Partially Malignant Phenotype of Osteosarcoma Cells by Inducing Apoptosis and Autophagy Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-07 Ruiqing Xu, Rui Huang, Jiandang Shi, Dawei Chu, Pengyu Yang
ObjectivesStudies have shown that Momordin Ic (MI) has an antitumor effect on liver cancer, gastric cancer, and colorectal cancer. However, its effect on osteosarcoma has not yet been reported. The purpose of this study was to explore the effect of MI on several malignant phenotypes of osteosarcoma cells.MethodsCCK-8 and EdU were used to evaluate the effect of MI on the proliferation of osteosarcoma
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Pachymic Acid Alleviates Oxidative Damage of Retinal Cells Induced by Sodium Iodate or Hydrogen Peroxide by Activating the Nrf2/HO-1 Signaling Pathway Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-31 Chengyao Qin, Xi Chen, Tianming Hu, Wenxiu Sun, Zehao Liu, Min Li, Yan Shao, Wei Wei
Background: Pachymic acid (PA), extracted from the traditional Chinese medicinal herb Poria cocos ( P cocos) is reported to protect organs such as the liver and lungs from damage. This study investigated the effect of PA on oxidative stress in the retina in vivo and in vitro. Methods: In vitro, retinal pigment epithelial (RPE) cells were treated with hydrogen peroxide to establish a cell model of oxidative
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Stability of Piceatannol in Dulbecco's Modified Eagle's Medium by In Situ UPLC-MS/MS Analysis Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Meng S. Cheong, Lutfun Nahar, Satyajit D. Sarker, Hui Cao, Wai S. Cheang, Jianbo Xiao
Piceatannol is a stilbenoid, which has shown bioactivities in various cell culture models. However, its stability in cell culture medium is not clear. Here, UPLC-MS/MS was applied in situ to analyze the degradation products of piceatannol in Dulbecco's Modified Eagle's Medium (DMEM) and cell culture to investigate the compound's stability in DMEM. During the incubation with cell culture medium (at
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Potential of 2-Hydroxyacetophenone Derivatives and Simple Phenol's for the control of Meloidogyne javanica Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Luis Alberto González López, Maria Fe Andres, Wiston Quiñones, Fernando Echeverri, Azucena Gonzalez-Coloma
Objective: In this study, a series of synthetic hydroxylated (5-10) and prenylated (10-17) acetophenones, chalcones (18-20) and a flavone (21) have been synthesized and evaluated on the nematode Meloidogyne javanica. Additional phenolic compounds, including salicylic acid, isopropyl salicylate, thymol, carvacrol, cumic acid, eugenol, vanillin, and vanillic acid (22-29), were also tested. Methods: Compounds
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Adenophorae Radix Reduces Fibrosis in a Bleomycin-Induced Pulmonary Fibrosis Mouse Model Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Eui-Joong Kim, Jiwon Park, Chang-Hwan Yu, Jae-Woo Park, Kwan-Il Kim, Hee-Jae Jung, Jang-Hoon Kim, Youngmin Bu, Beom-Joon Lee
Background: A screening study investigated the effects of lung-moistening herbal medicines on a bleomycin-induced pulmonary fibrosis mouse model and reported that the efficacy of Adenophorae Radix (ADR) was higher than that of other remedies. Objectives: This study aimed to investigate the antifibrotic efficacy and mechanism of action of ADR in a mouse model of bleomycin-induced pulmonary fibrosis
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Study on the Active Components and Inhibiting Effect of Melastoma dodecandrum Lour. on Human Cervical Cancer Cells Based on Spectrum–Effect Relationship Analysis Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Song Qian, Zuhua Wang, Xiuping Ma, Huiyi Ming, Jing Liu, Jing Yang, Teng Chen, Linli Liu, Jibian Ban, Jiangtao Guo
BackgroundThe ethnic drug Melastoma dodecandrum Lour. (MDL) is an important medicinal plant with potential antitumor properties, which have been proposed as promising anticancer agents, but the material basis for its therapeutic effect is still unclear and lacks in-depth research.MethodsIn this study, the in vitro antitumor effects of different MDL extracts in different gynecological tumor cells were
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Exploring the Biomedical Potential of Endophytic Fungi Isolated from Panamanian Mangroves Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Lilia Cherigo, Dioxelis López, Carmenza Spadafora, Luis C. Mejia, Sergio Martínez-Luis
Objective: The objective of this study was to assess the biomedical potential of endophytic fungi isolated from Panamanian mangrove plants. This was achieved through the biological evaluation of organic extracts to determine their antiparasitic, anticancer, toxicity activity, and inhibition of the enzyme α-glucosidase. Methods: Leaves from various mangrove plant species in five different zones along
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Diversity of Secondary Metabolites from Fungi of the Ascomycete Genus Tolypocladium Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Ting-Ting Niu, Wei-Qiong Chen, Wen-Xing Li, Li Zhang, Ying-Qiao Shan, Li-Wei Ren
Fungi in the genus of Tolypocladium are often discovered as endophytes, soil inhabitants, and insect pathogens. Many biologically active secondary metabolites have been discovered from them in the past half-century, including medicinally important oligopeptide cyclosporine A, and other compounds like terpenes, polyketides, polyketide-non-ribosomal peptides. This review has summarized the chemistry
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The Computational Interaction Analyses of Some Vitamin D-Related Compounds with Sterol 14-Demethylase (CYP51) – Could It Be a Glimmer of Hope to Find New Anti-Mucormycotic Drugs Extracted from Plants-Derived Sterols? Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-23 Mohammed Helmy Faris Shalayel, Ghassab M. Al-Mazaideh, Majed Meshal Almutairi, Wael A. Alsubhi, Abdullah K. Althaiban
IntroductionMany vitamin D analogs and sterols-related compounds have been identified and extracted from several plants including Solanaceae species. The aim of our study was to evaluate the antifungal potential of 15 vitamin D, D3 analogs, and some sterols-related compounds that have been detected in some plants along with 3 standard antifungal drugs, Isavuconazole, Fluconazole, and Voriconazole,
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Neolignan Glycoside and Other Constituents From the Leaves of Ligustrum sinense and Their Anti-Inflammatory Activity Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-23 Nong Thi Anh Thu, Lo Huyen Linh, Dao Anh Hoang, Nguyen Tu Oanh, Vu Mai Thao, Nguyen Thi Minh Hang, Nguyen Xuan Nhiem
Objectives: The aim of the project was the isolation, structure elucidation, and anti-inflammatory evaluation of compounds from the leaves of Ligustrum sinense Lour. Methods: Chromatographic techniques were used to isolate anti-inflammatory compounds from the methanol extract of L sinense leaves. The structures of compounds were elucidated by analyses of mass spectra, nuclear magnetic resonance data
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Antibacterial and Carbohydrate Digestive Enzyme Inhibitory Effects of Native Plants Used for Medicinal and Culinary Purposes in Cyprus Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-23 Atalanti Christou, Constantina Stavrou, Christodoulos Michael, George Botsaris, Vlasios Goulas
Natural products are an inexhaustive reservoir of bioactive compounds with diverse effects protecting human health as components of nutrition and as active substances of drugs. The objective of the present study was to evaluate the bactericidal and carbohydrate digestive enzyme inhibitory activity of twelve native plants from Cyprus, that are consumed for medicinal and/ or culinary purposes. Each plant
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Polyhydroxy Sterols Isolated From Ganoderma sinense Spores and Their Cytotoxic Activities Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-22 Danhong Lian, Xin Zhong, Lian Li, Li Gu, Yimei Zheng, Xin Liu
Background: The fruiting body of Ganoderma sinense Zhao, Xu et Zhang iscertified as an authoritative medical material in the Chinese Pharmacopoeia 2020 edition and has been used as a crude drug for a long time. G sinense spores are crucial part of the fruiting body of G sinense and exhibited antitumor and immune-enhancing activities according to our previous reports. However, there were few studies
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The Essential Oil of Balsamorhiza sagittata from Southwestern Idaho: Chemical Composition and Enantiomeric Distribution Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-18 Kathy Swor, Prabodh Satyal, Ambika Poudel, William N. Setzer
Background/Objective: Arrowleaf balsamroot ( Balsamorhiza sagittata (Pursh) Nutt., Asteraceae) is a conspicuous forb growing in open hillsides and prairies at mid to upper elevations in the Intermountain West and Rocky Mountain regions. The plant is important forage for deer and elk and several Native American tribes used arrowleaf balsamroot as food and medicine. The volatile phytochemicals of B.
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Antiviral Significance of Isoquercetin (Quercetin-3-O-Glucoside) With Special Reference to its Anti-Coronaviral Potential Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-10 Pawan K Agrawal, Gerald Blunden, Claus Jacob
Isoquercetin, a naturally occurring dietary flavonoid glycoside, has shown many promising biological activities, such as antioxidant, anti-inflammatory, and anticancer. It also exhibits broad-spectrum antiviral activity, significantly reducing cell infection by influenza, Zika, Ebola, and dengue viruses, among others. Its beneficial effect for mitigating the disease of COVID-19 can be explained due
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The Leaf Oils of Beilschmiedia tonkinensis (Lecomte) Ridl. and Lindera gracilipes H. W. Li: Chemical Composition, Cytotoxicity, Antimicrobial Activity, and Docking Study Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-10 Duong Quang Huan, Nguyen Dinh Luyen, Nguyen Xuan Ha, Do Ngoc Dai, Nguyen Quang Hop, Do Thi Lan Huong, Ninh The Son
ObjectiveThe Lauraceae plants comprised high amounts of essential oils, some of which established pharmacological potentials such as anticancer and antimicrobial activities. The Lauraceae essential oils are also used in cuisines and perfumes. The present study provides the chemical analysis of the leaf oils of Beilschmiedia tonkinensis and Lindera gracilipes, collected from Vietnam.MethodChemical components
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Chemical Correlation of Cistendiol Obtained from Cativic Acid in Two Different Pathways Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-09 David Calderón-Rangel, Hugo A García-Gutiérrez, Rosa E del Río, Christine Thomassigny
ObjectiveThis study aims to convert cativic acid, which was isolated from Ageratina jocotepecana, into cistendiol (5), an analog of cistenolic acid isolated from Cistus symphytifolius. The position of hydroxyl at C-7 in compound 5 could be achieved by applying the Schenck reaction with singlet oxygen (1O2) through photooxidation reaction of 6. Additionally, epoxidation reaction of 1, followed by further
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Garcinia Biflavonoid 1 from Garcinia kola Ameliorates Glycolipid Metabolism Disorder in Type 2 Diabetic db/db Mice Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-09 Ting-Dan Fu, Wen-Li Zhang, Ying Zhang, Chang-Sheng Deng, Wang Qi, Qin Xu, Jian-Ping Song, Wen-Feng Guo, Rui-Yi Yang, Xin-An Huang
Background: Garcinia kola is recommended in African folk medicine for the treatment of diabetes and its associated complications. In this study, we investigated the effects of Garcinia biflavonoid 1 (GB1), an active chemical component of Garcinia kola, on blood glucose and lipid in db/db mice with type 2 diabetes. Methods: Db/db mice were divided into 4 groups: vehicle, low-dose GB1 (50 mg/kg), high-dose
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Screening for Antimycobacterial Activity of Actinomycetes Collected in Vietnam – Isolation and Activity of Metabolites from Streptomyces alboniger (A121) Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-08 Ni Thi Ngoc Huynh, Ninh Thi Pham, Chien Van Tran, Dung Thi Nguyen, Mai Thi Ngoc Dinh, Van Thi Nguyen, Minh Hong Nguyen, Hieu Van Ngo, Anh Ngoc Ho, Jinhua Cheng, Joo-Won Suh, Sung Van Tran, Thao Kim Nu Nguyen, Thao Thi Phuong Tran
ObjectiveActinomycetes have been known to be the great natural sources to explore antibiotics for the treatment of tuberculosis (TB). The isolation of actinomycetes from the samples in Vietnam followed by the screening of their antimycobacterial activity was performed in this study. The metabolites isolated from the most active strain were further evaluated for their antimycobacterial, antimicrobial
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Potential Beneficial Effects of Salvianic Acid A and Salvianolic Acid B in Skin Whitening Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-05 Haifeng Sun, Ying Shen, Ying Zhang, Lei Zhou
ObjectiveNatural product-derived biomaterials are highly desired as possible ingredients in cosmetics, as they are often safe and effective. Salvianic acid A (SAA) and salvianolic acid B (SAB) are the primary water-soluble ingredients of Salvia miltiorrhiza Bunge ( Lamiaceae). These compounds have extensive applications as both effective and biocompatible bioactive agents for the treatment of various
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Optimizing Ultrasonic Extraction and Purification of Nuciferine With Response Surface Method Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-05 Xinshui Ren, Mengdie Wu, Simin Liu, Hongzhi Pan
BackgroundLotus leaves are obtained from plants belonging to the genus Nelumbo in the Nymphaeaceae family. They serve both as agricultural produce and traditional Chinese medicinal herbs. Nuciferine, an amorphine alkaloid found in lotus leaves, holds significance due to its anti-inflammatory, lipid-lowering, and hypoglycemic properties.ObjectiveThe factors influencing nuciferine extraction from lotus
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Chemical Profiling, Antibacterial Efficacy, and Synergistic Actions of Ptychotis verticillata Duby Essential Oil in Combination with Conventional Antibiotics Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-05 Mohamed Taibi, Amine Elbouzidi, Mounir Haddou, El Hassania Loukili, Reda Bellaouchi, Abdeslam Asehraou, Youssef Douzi, Mohamed Addi, Ahmad M Salamatullah, Hiba-Allah Nafidi, Mohammed Bourhia, Musaab Dauelbait, Bouchra El Guerrouj, Khalid Chaabane
Introduction: The primary aim of the current investigation is to assess the chemical composition and antibacterial efficacy of Ptychotis verticillata essential oil (PVEO) against three Gram-positive bacteria ( Staphylococcus aureus, Micrococcus luteus, and Bacillus subtilis) and three Gram-negative bacteria ( Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae). Furthermore, this research
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Augmentation of Docetaxel-Induced Cytotoxicity in Human PC-3 Androgen-Independent Prostate Cancer Cells by Combination With Four Natural Apoptosis-Inducing Anticancer Compounds. Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-05-22 Inass A Ahmed,Saly Hafiz,Sabrina van Ginkel,Satyanarayana R Pondugula,Azza S Abdelhaffez,Hayam G Sayyed,Ebtihal A Abd El-Aziz,Mahmoud M Mansour
Docetaxel (DTX) is the treatment of choice for metastatic castration-resistant prostate cancer. However, developing drug resistance is a significant challenge for achieving effective therapy. This study evaluated the anticancer and synergistic effects on DTX of four natural compounds (calebin A, 3'-hydroxypterostilbene, hispolon, and tetrahydrocurcumin) using PC-3 androgen-resistant human prostate
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Bioavailability of Flavonoids in Ginkgo biloba Extract-γ-Cyclodextrin Complex Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-05-11 Masamitsu Moriwaki, Etsuko Tominaga, Kento Kito, Ryo Nakagawa, Mahendra P. Kapoor, Yoshiki Matsumiya, Tomohisa Fukuhara, Junya Kobayashi, Kensuke Satomoto, Hiroshi Yamagata, Yuichi Kuroiwa
Ginkgo biloba extract (GBE) is an essential herbal supplement for diverse health perspectives. The present study aims to improve the oral bioavailability of GBE flavonoids. We formulated the GBE fl...
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Hepatoprotective and Antioxidant Activities of Phenolic Compounds from Heliciopsis terminalis Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-05-09 Bui V. Trung, Duong H. Anh, Pham H. Viet, Phan Van Kiem
ObjectiveHeliciopsis terminalis (Kurz.) Sleum (family Proteaceae) is distributed in India, Mianma, Thailand, Cambodia, Vietnam, and China. In Vietnamese traditional medicine, it is used as an antid...
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A Focused Review of the Pharmacological Potentials of Terrein as an Anticancer Agent Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-05-09 Jyoti Goutam, Gunjan Sharma, Vandana Yadav, Gauri Pathak, Ravindra Nath Kharwar, Divakar Sharma
Terrein is one of the most important biomolecules of fungal origin being studied from a medicinal perspective. Secondary metabolites are the intermediate products produced during the metabolism of ...
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A Systematic Study of Traditional Chinese Medicine for the Treatment of Lung Adenocarcinoma Using a Reverse Network of Key Targets Based on Bioinformatics and Molecular Docking: Curcumin and Trans-Resveratrol as Potential Drug Candidates for Lung Adenocarcinoma Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-05-07 Wujun Wang, Zhu Zeng, Junli Zhang, Zengtao Sun
BackgroundLung adenocarcinoma (LUAD) is a dominant tumor with high morbidity and mortality. In spite of innovations in surgery, chemotherapy, and targeted therapies, the prognosis for patients with...
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Interactions of Different Urolithins With Bovine Serum Albumin Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-05-07 Nevena Zelenovic, Milica Kojadinovic, Lidija Filipovic, Vesna Vucic, Milos Milcic, Aleksndra Arsic, Milica Popovic
Backgound/ObjectivesUrolithins (UROs) are the metabolites derived from the gut microbial action on ellagitannins and ellagic acid-rich foods. Following their absorption in the intestine, UROs are t...
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Aloin Induces Gastric Cancer Cell Apoptosis via the miR-5683/HMGB1 Signal Axis Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-05-07 Xuelei Chen, Xiaoming Wu, Fei Ge, Jin Cheng, Zhenyu Cheng, Zhilin Qi
Background: Recent studies conducted by us indicate that aloin (ALO) could promote gastric cancer (GC) cell apoptosis, but the underlying mechanism remains unclear. The high mobility group box 1 (H...
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A Literature Review on the Antiviral Mechanism of Luteolin Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-26 Peng Lu, Tingrui Zhang, Yali Ren, Huanan Rao, Jieting Lei, Guiying Zhao, Miao Wang, Daoyin Gong, Zhixing Cao
BackgroundViral infections pose some of the most serious human health concerns worldwide. The infections caused by several viruses, including coronavirus, hepatitis virus, and human immunodeficienc...
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In vitro Antioxidant, Enzyme Inhibitory and Antimicrobial Evaluation of Sideritis caesarea H. Duman, Aytaç & Başer Extracts Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-25 Tuğba Günbatan, İlhan Gürbüz, Nursenem Karaca, Fatih Demirci
Sideritis caesarea H. Duman, Aytaç & Başer of the family Lamiaceae is an endemic plant with different ethnobotanical uses in Anatolia. In this present study, the antioxidant and biological activity...
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Kaempferol Protects Against Apoptosis in PC12 Cells Exposed to Hydrogen Peroxide by Activating Akt1 Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-19 Erliang Li, Kang Yan, Rui Zhang, Peng Zou, Shuang Li, Qiong Ma, Bo Liao
ObjectiveSpinal cord injury (SCI) is a debilitating disease that cannot be cured at present. Kaempferol (KPL) has proven neuroprotective, antioxidant, and antibacterial properties. However, the neu...
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EF-24, a Curcumin Analogue, Could Inhibit HSP90 and Induce Apoptosis-Mediated by Autophagy/Inflammation/Oxidative Stress in Papillary Thyroid Cancer Cell Lines Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-19 Guangying Zhou, Yanting Zhang, Abolfazl Akbari, Xin Wang, Jing Wei
ObjectivePapillary thyroid cancer (PTC) is one of the most common thyroid cancers and its prevalence has increased in recent years. Studies have shown that autophagy, angiogenesis, inflammation, ox...
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Antiviral and Possible Prophylactic Significance of Myricetin for COVID-19 * Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-19 Pawan K. Agrawal, Chandan Agrawal, Gerald Blunden
Myricetin (3,5,7,3′,4′,5′ -hexahydroxyflavone), a common dietary flavonoid, has been reported for its roles in improving health due to various pharmacological activities, such as antioxidant, antim...
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Serum Metabolomics Combined With 16S rRNA Gene Sequencing to Analyze the Changes of Intestinal Flora in Rats With MI and the Intervention Effect of Fuling-Guizhi Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-19 Yan Ye, Jianghua Liu, Dan Zheng, Xiangfa Zeng, Zhenxiang Zhou, Lintao Han, Ping Huang, Fengyun Zhang, Wusheng Wang, Xuan Cheng, Fang Huang, Bailu Duan
Objective: This research aimed to assess the relationship between intestinal flora and metabolites in rats with myocardial ischemia (MI) and to offer a new perspective to elucidate the pathological...
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Essential Oils of Ginkgo biloba Yellow Leaves Obtained by Hydrodistillation and Supercritical Carbon Dioxide Extraction Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-18 Nina Djapic
Background/Objective: Volatile compounds present in green Ginkgo biloba L. leaves extracts contain compounds that can undertake free radical scavenging. The assumption was that volatile compounds p...
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Volatile Components and Biological Activities of n-Hexane Extract From Rhizomes of Homalomena cochinchinensis Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-10 Linh Thuy Khanh Nguyen, Phu Quynh Dinh Nguyen, Nghia Ai Thi Doan, Chau Bao Hoai Nguyen, Tuan Quoc Doan, Linh Thuy Thi Tran, Hoai Thi Nguyen, Duc Viet Ho
In this study, we analyzed the volatile constituents of the n-hexane extract from the rhizomes of Homalomena cochinchinensis Engl. by gas chromatography-mass spectrometry (GC-MS). We also investiga...
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Qinteng Tongbi Decoction Medicated Serum Exerts Regulates the Proliferation, Migration, and Apoptosis of Synovial Fibroblasts in Adjuvant-Induced Arthritis Rats Model via Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-06 Guo-Cheng Liang, Wen-Gui Duan, Shu-Yin Chen, Xue-Feng Pang, Jian-Kang Fang
BackgroundQinteng Tongbi decoction (QTTBD) was an empirical prescription that could effectively prevent and treat rheumatoid arthritis (RA), but there was no report of pharmacological studies on th...
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Synthesis and Anticancer Activity of Ergosterol Peroxide Hybrids With Paclitaxel Side Chain Inducing Apoptosis in Human Hepatoma Carcinoma Cells Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-06 Xiaoshan Guo, Wenkang Ren, Zhen Lv, Gang Li, Hongling Li, Mingrui Sun, Xiaoming Li, Gang Chen, Zhiguo Zhang, Wenting Zhang, Ming Bu
The antitumor activities of natural paclitaxel (PTX), semisynthetic docetaxel, and cabazitaxel are highly dependent on their C-13 side chains. Therefore, using natural ergosterol peroxide (EP, 1) a...
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Phytochemical Analysis of the Essential Oils From the Rhizomes of Three Vietnamese Curcuma Species and Their Antimicrobial Activity Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-05 Hieu Tran-Trung, Xuan Duc Dau, Thi Chung Nguyen, Hien Nguyen-Thi-Thu, Hieu Nguyen-Ngoc, Thi Giang An Nguyen, Van Trung Hoang, Dang-Khoa Nguyen, Danh Duc Nguyen, Chen Tran Van, Le Duc Giang
Objective/BackgroundThe essential oils (EOs) of Curcuma species contain various volatile compounds with bioactivity. However, the phytochemical profile of Curcuma thorelii and the antimicrobial act...
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Luteolin-Zn Complex Inhibits Invasion and Migration of M2-Like TAMs via the Downregulation of AMPK/mTOR and PI3K/Akt/mTOR Signaling Pathway Under Hypoxia Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-04 Chenyang Mao, Yongling Wang, Zhenhua Xu, Xiaowu Wang, Binbo Fang, Haihua Chen
Purpose: The high mortality rate of malignant tumors is often attributable to the loss of surgical opportunities due to late diagnosis when invasion and metastasis have significantly affected the p...
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Emodin Exerts its Therapeutic Effects Through Metabolic Remodeling in Severe Acute Pancreatitis-Related Intestinal Injury Nat. Prod. Commun. (IF 1.8) Pub Date : 2023-04-03 Minjie Wang, Chen Pan, Dawei Deng, Mingzheng Xie, Yongqing Cao
BackgroundIntestinal injury caused by severe acute pancreatitis (SAP) can induce peripancreatic and systemic infection, and aggravate systemic inflammation. Emodin has demonstrated efficacy in miti...