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Photooxidation of 2,3-dihydroquinazolin-4(1 H )-ones: retention or elimination of 2-substitution Mol. Divers. (IF 2.013) Pub Date : 2021-01-15 Hamid Reza Memarian, Reza Aghalar
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Synthesis of new chrysin derivatives with substantial antibiofilm activity Mol. Divers. (IF 2.013) Pub Date : 2021-01-12 Sukhen Bhowmik, Pragya Anand, Riyanki Das, Tirtharaj Sen, Yusuf Akhter, Manash C. Das, Utpal C. De
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New organosulfur metallic compounds as potent drugs: synthesis, molecular modeling, spectral, antimicrobial, drug likeness and DFT analysis Mol. Divers. (IF 2.013) Pub Date : 2021-01-07 Abrar Ul Hassan, Sajjad Hussain Sumrra, Muhammad Nadeem Zafar, Muhammad Faizan Nazar, Ehsan Ullah Mughal, Muhammad Naveed Zafar, Mazhar Iqbal
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First structure–activity relationship analysis of SARS-CoV-2 virus main protease (Mpro) inhibitors: an endeavor on COVID-19 drug discovery Mol. Divers. (IF 2.013) Pub Date : 2021-01-05 Sk. Abdul Amin, Suvankar Banerjee, Samayaditya Singh, Insaf Ahmed Qureshi, Shovanlal Gayen, Tarun Jha
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COVID-19: inflammatory responses, structure-based drug design and potential therapeutics Mol. Divers. (IF 2.013) Pub Date : 2021-01-05 Neetu Tripathi, Neeraj Tripathi, Manoj Kumar Goshisht
The COVID-19 pandemic caused by SARS-CoV-2 is responsible for the global health emergency. Here, we explore the diverse mechanisms of SARS-CoV-induced inflammation. We presume that SARS-CoV-2 likely contributes analogous inflammatory responses. Possible therapeutic mechanisms for reducing SARS-CoV-2-mediated inflammatory responses comprise FcR inactivation. Currently, there is no specific remedy available
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Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives Mol. Divers. (IF 2.013) Pub Date : 2021-01-05 Mohamed Ahmed Mahmoud Abdel Reheim, Ibrahim Saad Abdel Hafiz, Hend Saad Eldin Abdel Rady
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Identification of novel inhibitors of angiotensin-converting enzyme 2 (ACE-2) receptor from Urtica dioica to combat coronavirus disease 2019 (COVID-19) Mol. Divers. (IF 2.013) Pub Date : 2021-01-04 Shobha Upreti, Jyoti Sankar Prusty, Satish Chandra Pandey, Awanish Kumar, Mukesh Samant
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Layered double hydroxides as heterogeneous catalyst systems in the cross-coupling reactions: an overview Mol. Divers. (IF 2.013) Pub Date : 2021-01-04 Majid M. Heravi, Pourya Mohammadi
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Curse of La Corona: unravelling the scientific and psychological conundrums of the 21st century pandemic Mol. Divers. (IF 2.013) Pub Date : 2021-01-04 Arpit Shukla, Paritosh Parmar, Gitanjali Kapoor, Dweipayan Goswami, Chaitanya Kumar Jha, Baldev Patel, Meenu Saraf
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Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2 E69K Mol. Divers. (IF 2.013) Pub Date : 2021-01-03 Shan Du, Xin-hua Lu, Wei-Ya Li, Li-Peng Li, Yang-Chun Ma, Liang Zhou, Jing-Wei Wu, Ying Ma, Run-Ling Wang
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Structural modification of 4, 5-dihydro-[1, 2, 4] triazolo [4, 3-f] pteridine derivatives as BRD4 inhibitors using 2D/3D-QSAR and molecular docking analysis Mol. Divers. (IF 2.013) Pub Date : 2021-01-03 Jian-Bo Tong, Ding Luo, Yi Feng, Shuai Bian, Xing Zhang, Tian-Hao Wang
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A review on various aspects of organic synthesis using Comins’ reagent Mol. Divers. (IF 2.013) Pub Date : 2021-01-03 Duraipandi Devi Priya, Chetan Lakshman, Selvaraj Mohana Roopan
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An efficient diastereoselective synthesis of novel fused 5 H -furo[2,3- d ]thiazolo[3,2- a ]pyrimidin-5-ones via one-pot three-component reaction Mol. Divers. (IF 2.013) Pub Date : 2021-01-03 Tooba Tabibi, Abbas Ali Esmaeili, Joel T. Mague
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The anti-HCV, Sofosbuvir, versus the anti-EBOV Remdesivir against SARS-CoV-2 RNA dependent RNA polymerase in silico Mol. Divers. (IF 2.013) Pub Date : 2021-01-03 Abdo A. Elfiky, Eman B. Azzam, Medhat W. Shafaa
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CoViTris2020 and ChloViD2020: a striking new hope in COVID-19 therapy Mol. Divers. (IF 2.013) Pub Date : 2021-01-03 Amgad M. Rabie
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Environmentally benign approach towards C–S cross-coupling reaction by organo-copper(II) complex Mol. Divers. (IF 2.013) Pub Date : 2021-01-03 Rabindranath Singha, Sailesh Chettri, Dhiraj Brahman, Biswajit Sinha, Pranab Ghosh
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Designing of peptide aptamer targeting the receptor-binding domain of spike protein of SARS-CoV-2: an in silico study Mol. Divers. (IF 2.013) Pub Date : 2021-01-02 Arpita Devi, Nyshadham S. N. Chaitanya
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Monophosphoramide derivatives: synthesis and crystal structure, theoretical and experimental studies of their biological effects Mol. Divers. (IF 2.013) Pub Date : 2021-01-02 Khodayar Gholivand, Zahra Roshanian, Maryam Rahimzadeh Dashtaki, Zahra Hosseini, Ali Asghar Ebrahimi Valmoozi, Mahboobeh Sharifi, Fahimeh Mohammadpanah, Maryam Rajabi, Mohammad Ghadamyari, Sedigheh Farshadian, Reza Hasan Sajedi, Khosro Khajeh, Neda Akbari
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A new synthetic approach for pyrazolo[1,5- a ]pyrazine-4(5 H )-one derivatives and their antiproliferative effects on lung adenocarcinoma cell line Mol. Divers. (IF 2.013) Pub Date : 2021-01-02 Meltem Tan Uygun, Karina Amudi, İrem Doğan Turaçlı, Nurettin Menges
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Design, synthesis and SAR of antitubercular benzylpiperazine ureas Mol. Divers. (IF 2.013) Pub Date : 2021-01-01 Sohal Satish, Rohan Chitral, Amitkumar Kori, Basantkumar Sharma, Jayashree Puttur, Afreen A. Khan, Deepali Desle, Kavita Raikuvar, Aaron Korkegian, Elvis A. F. Martis, Krishna R. Iyer, Evans C. Coutinho, Tanya Parish, Santosh Nandan
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Computational guided identification of a citrus flavonoid as potential inhibitor of SARS-CoV-2 main protease Mol. Divers. (IF 2.013) Pub Date : 2020-11-25 Neelutpal Gogoi, Purvita Chowdhury, Ashis Kumar Goswami, Aparoop Das, Dipak Chetia, Bhaskarjyoti Gogoi
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Virtual screening and drug repurposing experiments to identify potential novel selective MAO-B inhibitors for Parkinson’s disease treatment Mol. Divers. (IF 2.013) Pub Date : 2020-11-25 Luminita Crisan, Daniela Istrate, Alina Bora, Liliana Pacureanu
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Synthesis and biological evaluation in vitro and in silico of N -propionyl- N ′-benzeneacylhydrazone derivatives as cruzain inhibitors of Trypanosoma cruzi Mol. Divers. (IF 2.013) Pub Date : 2020-11-20 Timoteo Delgado-Maldonado, Benjamín Nogueda-Torres, José C. Espinoza-Hicks, Lenci K. Vázquez-Jiménez, Alma D. Paz-González, Alfredo Juárez-Saldívar, Gildardo Rivera
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Molecular docking studies, molecular dynamics and ADME/tox reveal therapeutic potentials of STOCK1N-69160 against papain-like protease of SARS-CoV-2 Mol. Divers. (IF 2.013) Pub Date : 2020-11-17 Olusola Olalekan Elekofehinti, Opeyemi Iwaloye, Sunday Solomon Josiah, Akeem Olalekan Lawal, Moses Orimoloye Akinjiyan, Esther Opeyemi Ariyo
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Synthesis and evaluation of ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives as anti-inflammatory agents Mol. Divers. (IF 2.013) Pub Date : 2020-11-17 Tian-Yi Zhang, Chun-Shi Li, Ping Li, Xue-Qian Bai, Shu-Ying Guo, Ying Jin, Sheng-Jun Piao
Here, two series of novel ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives were synthesized and screened for their anti-inflammatory activity by evaluating their inhibition effect of using LPS-induced inflammatory response in RAW 264.7 macrophages in vitro; the effects of different concentrations of the compounds on the secretion of nitric oxide (NO) and inflammatory cytokines including
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Current advances in the synthetic strategies of 2-arylbenzothiazole Mol. Divers. (IF 2.013) Pub Date : 2020-11-12 Ayushi Sethiya, Nusrat Sahiba, Pankaj Teli, Jay Soni, Shikha Agarwal
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[TBP] 2 SO 4 ionic liquid catalyst for 4MCR of pyridazinoindazole, indazolophthalazine and pyrazolophthalazine derivatives Mol. Divers. (IF 2.013) Pub Date : 2020-11-05 Najmeh Amirmahani, Nosrat O. Mahmoodi, Mohammad Malakootian, Abbas Pardakhty
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Using Chou’s 5-steps rule to study pharmacophore-based virtual screening of SARS-CoV-2 Mpro inhibitors Mol. Divers. (IF 2.013) Pub Date : 2020-10-20 Hemlata Pundir, Tanuja Joshi, Tushar Joshi, Priyanka Sharma, Shalini Mathpal, Subhash Chandra, Sushma Tamta
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Synthesis of 4-alkylaminoimidazo[1,2- a ]pyridines linked to carbamate moiety as potent α -glucosidase inhibitors Mol. Divers. (IF 2.013) Pub Date : 2020-10-12 Mina Saeedi, Maryam Raeisi-Nafchi, Sepideh Sobhani, Seyedeh Sara Mirfazli, Mahsa Zardkanlou, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Tahmineh Akbarzadeh
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Itaconic acid hybrids as potential anticancer agents Mol. Divers. (IF 2.013) Pub Date : 2020-10-11 Ivana Perković, Maja Beus, Dominique Schols, Leentje Persoons, Branka Zorc
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Facile synthesis of pyrrolo[2,1- a ]isoquinolines by domino reaction of 1-aroyl-3,4-dihydroisoquinolines with conjugated ketones, nitroalkenes and nitriles Mol. Divers. (IF 2.013) Pub Date : 2020-10-10 Grigorii S. Astakhov, Rinat R. Shigaev, Tatiana N. Borisova, Anastasia A. Ershova, Alexander A. Titov, Alexey V. Varlamov, Leonid G. Voskressensky, Maria D. Matveeva
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A multimodal deep learning-based drug repurposing approach for treatment of COVID-19 Mol. Divers. (IF 2.013) Pub Date : 2020-09-30 Seyed Aghil Hooshmand, Mohadeseh Zarei Ghobadi, Seyyed Emad Hooshmand, Sadegh Azimzadeh Jamalkandi, Seyed Mehdi Alavi, Ali Masoudi-Nejad
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Identification of potential inhibitors of coronavirus hemagglutinin-esterase using molecular docking, molecular dynamics simulation and binding free energy calculation Mol. Divers. (IF 2.013) Pub Date : 2020-09-29 Chirag N. Patel, Sivakumar Prasanth Kumar, Himanshu A. Pandya, Rakesh M. Rawal
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Revisit to the synthesis of 1,2,3,4-tetrasubstituted pyrrole derivatives in lactic acid media as a green solvent and catalyst. Mol. Divers. (IF 2.013) Pub Date : 2020-09-27 Dilek Akbaslar,E Sultan Giray,Oztekin Algul
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Visible-light-mediated one-pot efficient synthesis of 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles: a metal-free photochemical approach in aqueous ethanol. Mol. Divers. (IF 2.013) Pub Date : 2020-09-27 Mohd Nazeef,Km Neha Shivhare,Shabir Ali,Saif Ansari,I R Siddiqui
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Synthesis, characterization, antibacterial evaluation, 2D-QSAR modeling and molecular docking studies for benzocaine derivatives. Mol. Divers. (IF 2.013) Pub Date : 2020-09-25 Israa Taha,Eman M Keshk,Abdel-Galil M Khalil,Ahmed Fekri
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The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase. Mol. Divers. (IF 2.013) Pub Date : 2020-09-24 Stephanus J Cloete,Clarina I N'Da,Lesetja J Legoabe,Anél Petzer,Jacobus P Petzer
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Anticancer activity and evaluation of apoptotic genes expression of 2-azetidinones containing anthraquinone moiety. Mol. Divers. (IF 2.013) Pub Date : 2020-09-18 Masoud Mohamadzadeh,Maaroof Zarei
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Synthesis of 1,2,3-triazolyl nucleoside analogues and their antiviral activity. Mol. Divers. (IF 2.013) Pub Date : 2020-09-15 Olga V Andreeva,Bulat F Garifullin,Vladimir V Zarubaev,Alexander V Slita,Iana L Yesaulkova,Liliya F Saifina,Marina M Shulaeva,Maya G Belenok,Vyacheslav E Semenov,Vladimir E Kataev
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Synthesis of 3,3'-methylenebis(4-hydroxyquinolin-2(1H)-ones) of prospective anti-COVID-19 drugs. Mol. Divers. (IF 2.013) Pub Date : 2020-09-14 Ashraf A Aly,Alaa A Hassan,Asmaa H Mohamed,Esraa M Osman,Stefan Bräse,Martin Nieger,Mahmoud A A Ibrahim,Sara M Mostafa
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Selection of antileishmanial sesquiterpene lactones from SistematX database using a combined ligand-/structure-based virtual screening approach. Mol. Divers. (IF 2.013) Pub Date : 2020-09-09 Chonny Herrera-Acevedo,Mayara Dos Santos Maia,Élida Batista Vieira Sousa Cavalcanti,Ericsson Coy-Barrera,Luciana Scotti,Marcus Tullius Scotti
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Most recent strategies targeting estrogen receptor alpha for the treatment of breast cancer. Mol. Divers. (IF 2.013) Pub Date : 2020-09-04 Nitish Kumar,Harmandeep Kaur Gulati,Aakriti Sharma,Shilpa Heer,Anupmjot Kaur Jassal,Lovenish Arora,Simranpreet Kaur,Atamjit Singh,Kavita Bhagat,Arshmeet Kaur,Harbinder Singh,Jatinder Vir Singh,Preet Mohinder Singh Bedi
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Therapeutics for COVID-19: from computation to practices-where we are, where we are heading to. Mol. Divers. (IF 2.013) Pub Date : 2020-09-02 Probir Kumar Ojha,Supratik Kar,Jillella Gopala Krishna,Kunal Roy,Jerzy Leszczynski
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Understanding the enzymatic inhibition of intestinal alkaline phosphatase by aminophenazone-derived aryl thioureas with aided computational molecular dynamics simulations: synthesis, characterization, SAR and kinetic profiling. Mol. Divers. (IF 2.013) Pub Date : 2020-08-29 Asma Khurshid,Aamer Saeed,Zaman Ashraf,Qamar Abbas,Mubashir Hassan
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Dehydroabietylamine-based thiazolidin-4-ones and 2-thioxoimidazolidin-4-ones as novel tyrosyl-DNA phosphodiesterase 1 inhibitors. Mol. Divers. (IF 2.013) Pub Date : 2020-08-24 Kseniya Kovaleva,Evgeniya Mamontova,Olga Yarovaya,Olga Zakharova,Alexandra Zakharenko,Olga Lavrik,Nariman Salakhutdinov
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Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through inhibition of STAT3: synthesis and in silico mechanistic studies. Mol. Divers. (IF 2.013) Pub Date : 2020-08-23 Abdallah Turky,Ashraf H Bayoumi,Farag F Sherbiny,Khaled El-Adl,Hamada S Abulkhair
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Discovery of new small-molecule cyclin-dependent kinase 6 inhibitors through computational approaches. Mol. Divers. (IF 2.013) Pub Date : 2020-08-08 Xiaojiao Luo,Yu Zhao,Pan Tang,Xingkai Du,Feng Li,Qingying Wang,Rong Li,Jun He
Abstract Excessive cell proliferation due to cell cycle disorders is one of the hallmarks of breast cancer. Cyclin-dependent kinases (CDKs), which are involved in the transition of the cell cycle from G1 phase to S phase by combining CDKs with cyclin, are considered promising targets with broad therapeutic potential based on their critical role in cell cycle regulation. Pharmacological evidence has
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Ultrasound-assisted, low-solvent and acid/base-free synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols as potent antimicrobial and antioxidant agents. Mol. Divers. (IF 2.013) Pub Date : 2020-08-08 Elahe Yarmohammadi,Hamid Beyzaei,Reza Aryan,Ashraf Moradi
Abstract One of the goals of green chemistry is to use environmentally friendly solvents or remove and reduce the volume of harmful spent solvents. In this study, a novel process for the synthesis of 5-substituted 1,3,4-oxadiazole-2-thiol derivatives was proposed via ultrasound-assisted reaction of aryl hydrazides with CS2 (1:1 molar ratio) in some drops of DMF in the absence of basic or acidic catalysts
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Modeling and simulation study to identify threonine synthase as possible drug target in Leishmania major. Mol. Divers. (IF 2.013) Pub Date : 2020-07-31 Rohan J Meshram,Kamini T Bagul,Snehal U Aouti,Akshay M Shirsath,Harleen Duggal,Rajesh N Gacche
Abstract Leishmaniasis is one of the most neglected tropical diseases that demand immediate attention to the identification of new drug targets and effective drug candidates. The present study demonstrates the possibility of using threonine synthase (TS) as a putative drug target in leishmaniasis disease management. We report the construction of an effective homology model of the enzyme that appears
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Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach. Mol. Divers. (IF 2.013) Pub Date : 2020-07-31 Ashish M Kanhed,Dushyant V Patel,Divya M Teli,Nirav R Patel,Mahesh T Chhabria,Mange Ram Yadav
Abstract The Corona virus Disease (COVID-19) is caused because of novel coronavirus (SARS-CoV-2) pathogen detected in China for the first time, and from there it spread across the globe creating a worldwide pandemic of severe respiratory complications. The virus requires structural and non-structural proteins for its multiplication that are produced from polyproteins obtained by translation of its
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Synthesis of pyrazole-4-carboxamides as potential fungicide candidates. Mol. Divers. (IF 2.013) Pub Date : 2020-07-30 Cuntao Dong,Wei Gao,Xiaotian Li,Susu Sun,Jingqian Huo,Yanen Wang,Da Ren,Jinlin Zhang,Lai Chen
Abstract A series of novel pyrazole-4-carboxamides were rationally designed, synthesized, and their structures were characterized by 1H NMR, 13C NMR and HRMS. Preliminary bioassay showed that four compounds 8g, 8j, 8o and 8s exhibited more than 90% and even completed inhibition against Alternaria solani at 100 μg/mL; and 8d displayed 100% inhibition against Fusarium oxysporum at the same concentration
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Recent strategies in the synthesis of thiophene derivatives: highlights from the 2012-2020 literature. Mol. Divers. (IF 2.013) Pub Date : 2020-07-30 Fahimeh Abedinifar,Elham Babazadeh Rezaei,Mahmood Biglar,Bagher Larijani,Halleh Hamedifar,Samira Ansari,Mohammad Mahdavi
Thiophene-based analogs have been fascinated by a growing number of scientists as a potential class of biologically active compounds. Furthermore, they play a vital role for medicinal chemists to improve advanced compounds with a variety of biological effects. The current review envisioned to highlight some recent and particularly remarkable examples of the synthesis of thiophene derivatives by heterocyclization
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A facile green synthesis of MgCoFe2O4 nanomaterials with robust catalytic performance in the synthesis of pyrano[2,3-d]pyrimidinedione and their bis-derivatives. Mol. Divers. (IF 2.013) Pub Date : 2020-07-27 Monireh Atarod,Javad Safari,Maryam Tavakolizadeh,Ali Pourjavadi
Abstract In this study, an efficient, rapid and simple plant-mediated green sol–gel auto-combustion procedure was presented to synthesis magnesium–cobalt ferrite (MgCoFe2O4) nanocatalyst using an aqueous extract of apple skins as a chelating/combustion agent. The catalyst was assessed by multiple techniques, including FT-IR, XRD, FE-SEM, EDS, elemental mapping, TGA-DTA and VSM. Then, the catalytic
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Recent synthetic strategies toward the synthesis of spirocyclic compounds comprising six-membered carbocyclic/heterocyclic ring systems. Mol. Divers. (IF 2.013) Pub Date : 2020-07-21 Kashaf Babar,Ameer Fawad Zahoor,Sajjad Ahmad,Rabia Akhtar
Abstract Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their skeleton and are effective in pharmaceutical industry. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. In this review, recent synthetic approaches
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4H-benzochromene derivatives as novel tyrosinase inhibitors and radical scavengers: synthesis, biological evaluation, and molecular docking analysis. Mol. Divers. (IF 2.013) Pub Date : 2020-07-18 Somaye Karimian,Sara Ranjbar,Mahsa Dadfar,Mahsima Khoshneviszadeh,Maryam Gholampour,Amirhossein Sakhteman,Mehdi Khoshneviszadeh
Abstract A series of ethyl 2-amino-4H-benzo[h]chromene-3-carboxylate derivatives, having phenyl ring with diverse substituents at C4 position of 4H-benzochromene nucleus, were synthesized via one-pot three-component reaction between various aromatic aldehydes, α-naphthol, and ethyl cyanoacetate. The synthesized compounds were screened for their antityrosinase activity. Compound 4i, bearing 4-dimethylamino
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A drug-biomarker interaction model to predict the key targets of Scutellaria barbata D. Don in adverse-risk acute myeloid leukaemia. Mol. Divers. (IF 2.013) Pub Date : 2020-07-16 Teng Wang,Chun-Yi Lyu,Yue-Hua Jiang,Xue-Yan Dong,Yan Wang,Zong-Hong Li,Jin-Xin Wang,Rui-Rong Xu
Abstract A poor prognosis, relapse and resistance are burning issues during adverse-risk acute myeloid leukaemia (AML) treatment. As a natural medicine, Scutellaria barbata D. Don (SBD) has shown impressive antitumour activity in various cancers. Thus, SBD may become a potential drug in adverse-risk AML treatment. This study aimed to screen the key targets of SBD in adverse-risk AML using the drug–biomarker
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Antiproliferative activity of cardenolides on cell line A549: structure-activity relationship analysis. Mol. Divers. (IF 2.013) Pub Date : 2020-07-05 Salvador Enrique Meneses-Sagrero,Luisa Alondra Rascón-Valenzuela,Rogerio Sotelo-Mundo,Wagner Vilegas,Carlos Velazquez,Juan Carlos García-Ramos,Ramón Enrique Robles-Zepeda
Abstract Since the beginning, natural products have represented an important source of bioactive molecules for cancer treatment. Among them, cardenolides attract the attention of different research groups due to their cardiotonic and antitumor activity. The observed biological activity is closely related to their Na+/K+-ATPase inhibition potency. Currently, the discovery of new compounds against cancer
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Antiproliferative and antiinflammatory coxib-combretastatin hybrids suppress cell cycle progression and induce apoptosis of MCF7 breast cancer cells. Mol. Divers. (IF 2.013) Pub Date : 2020-06-30 Quoc Anh Ngo,Thuy Hang Nguyen Thi,Minh Quan Pham,Domenico Delfino,Thi Thao Do
In our study, some newly synthesized aryl-substituted pyrazole derivatives mimicking cis-diphenylethylene scaffold of two apoptotic inducing agents celecoxib and combretastatin A-4 were found to have strong antiproliferative as well as antiinflammatory activities. Among these coxib–combretastatin hybrids, two lead compounds 8 and 6c simultaneously inhibited prostaglandin E2 (PGE2) production in LPS-activated
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Structure-based screening of novel lichen compounds against SARS Coronavirus main protease (Mpro) as potentials inhibitors of COVID-19. Mol. Divers. (IF 2.013) Pub Date : 2020-06-29 Tanuja Joshi,Priyanka Sharma,Tushar Joshi,Hemlata Pundir,Shalini Mathpal,Subhash Chandra
Abstract The outbreak of SARS-CoV-2 and deaths caused by it all over the world have imposed great concern on the scientific community to develop potential drugs to combat Coronavirus disease-19 (COVID-19). In this regard, lichen metabolites may offer a vast reservoir for the discovery of antiviral drug candidates. Therefore, to find novel compounds against COVID-19, we created a library of 412 lichen
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Comparative biological study between quinazolinyl-triazinyl semicarbazide and thiosemicarbazide hybrid derivatives. Mol. Divers. (IF 2.013) Pub Date : 2020-06-28 Janki J Patel,Rahul P Modh,Manjoorahmed Asamdi,Kishor H Chikhalia
Abstract Practical synthesis and biological activities of quinazolinyl–triazinyl semicarbazides (10a–j) and quinazolinyl–triazinyl thiosemicarbazides (11a–j) have been described. The novel semicarbazides and thiosemicarbazides were prepared by condensation of different nucleophiles like isocyanate and isothiocyanate by the displacement of chlorine atoms on the basis of functionality concept on varying
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