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Synthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy water J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2021-01-26 Jack S. Rowbotham; Adam P. Hardy; Holly A. Reeve; Kylie A. Vincent
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A Facile Synthesis of Isotope Labeled Acylcarnitines J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2021-01-21 Xiaojun Dai; Chao Lv; Jianguo Sun; Shuwei Li
Acylcarnitines are a big family of small molecule metabolites with various acyl groups attached to the hydroxyl moiety of L‐carnitine. They are good indicators of multiple metabolic disorders. For instance, the newborn screening panel uses flow injection tandem mass spectrometry to analyze more than 30 different acylcarnitines and amino acids extracted from dried blood spots. A facile approach has
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Production of [89Zr]Oxinate4 and cell radiolabeling for human use J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-12-16 Adriana V.F. Massicano; Jennifer L. Bartels; Charlotte D. Jeffers; Bryant K. Crenshaw; Hailey Houson; Christina Mueller; Jarred W. Younger; Paul Knapp; Jonathan E. McConathy; Suzanne E. Lapi
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Review: Self‐radiolysis of Compounds Containing Tritium and Carbon‐14 J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2021-01-13 Jeremy R. Wolf
Energy released from beta emission causes molecules which incorporate tritium (3H) and carbon‐14 (14C) atoms to be less stable than their stable labeled counterparts, thus making radiolabeled compounds prone to self‐radiolysis. This literature review examines the stability of organic compounds incorporating 3H and 14C atoms and discusses stability of the compound with respect to functional groups within
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Preparation, quality control, and biodistribution assessment of [111In]In‐DOTA‐PR81 in BALB/c mice bearing breast tumors J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-12-02 Sareh Abbas Abadi; Behrouz Alirezapour; István Kertész; Mohammad Javad Rasaee; Javad Mohammadnejad; Malihe Paknejad; Hassan Yousefnia; Samaneh Zolghadri
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2021-01-10
No abstract is available for this article.
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The impact of radiochemistry in drug projects: The use of C‐14 label in the AZD8529, AZD7325, and AZD6280 projects J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-12-16 Lee Kingston; Chungang Gu; Jian Guo; Steve Swallow; Charles S. Elmore
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An updated synthesis of N1′‐([11C]methyl)naltrindole for positron emission tomography imaging of the delta opioid receptor J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-12-03 Tanpreet Kaur; Allen F. Brooks; Brian G. Hockley; Jovany Torres; Bradford D. Henderson; Peter J.H. Scott; Xia Shao
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Fluorine‐18 labelled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-12-11 Troels E. Jeppesen; Jesper B. Kristensen; Carsten Behrens; Jacob Madsen; Andreas Kjaer
18F‐labelled aldehydes can be utilized for oxime coupling with chemically sensitive proteins, such as coagulation factor VII (FVII), if they are sufficiently reactive and can react in an aqueous solvent. New 18F‐labelled non‐volatile aldehyde prosthetic groups derived from [18F]F‐Py‐TFP and spirocyclic iodonium (III)ylide precursors for late stage 18F‐labelling were developed. These precursors were
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-12-09
No abstract is available for this article.
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Preclinical evaluation of [11C]L‐235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-11-23 Idriss Bennacef; Daniel Rubins; Kerry Riffel; Mangay Williams; Diane J. Posavec; Marie A. Holahan; Mona L. Purcell; Hyking D. Haley; Mary Wolf; Shawn J. Stachel; Laura S. Lubbers; Gregg A. Wesolowski; Le T. Duong; Terence G. Hamill; Jeffrey L. Evelhoch; Eric D. Hostetler
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High‐yield synthesis of a tau PET radioligand and its nonradioactive ligand using an alternative protection and deprotection strategy J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-30 Hyunjung Kim; Yearn Seong Choe
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Use of radioiodine in nuclear medicine—A brief overview J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-22 Trevor Ferris; Laurence Carroll; Sarah Jenner; Eric O. Aboagye
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Development of a novel [18F]fluorobenzyl derivative of the AT1 receptor antagonist Candesartan J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-20 Luis Michel Alonso Martinez; Jean N. DaSilva
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Development of a 68Ga‐labelled PET tracer for carbonic anhydrase IX‐overexpressed tumors using the artificial sweetener saccharin J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-29 Un chul Shin; Jeong Su Choi; Yeon Jae Beak; Min woo Lee; Hyung Soo Kim; Dal Woong Choi; Dong Gil Kim; Suhng Wook Kim
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Radiosynthesis and quality control testing of the tau imaging positron emission tomography tracer [18F]PM‐PBB3 for clinical applications J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-17 Kazunori Kawamura; Hiroki Hashimoto; Kenji Furutsuka; Takayuki Ohkubo; Tomoya Fujishiro; Takahiro Togashi; Daisuke Arashi; Toshiyuki Sakai; Masatoshi Muto; Masanao Ogawa; Yusuke Kurihara; Nobuki Nengaki; Makoto Takei; Kazuyoshi Nemoto; Makoto Higuchi; Ming‐Rong Zhang
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Automated radiosynthesis of [68Ga]Ga‐PSMA‐11 and [177Lu]Lu‐PSMA‐617 on the iPHASE MultiSyn module for clinical applications J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-17 Christian W. Wichmann; Uwe Ackermann; Stan Poniger; Kenneth Young; Benjamin Nguyen; Gordon Chan; John Sachinidis; Andrew M. Scott
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-11-03
No abstract is available for this article.
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Synthesis of stable-isotope-labeled N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide and N-(3-dimethylaminopropyl)-N'-ethylurea. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-08-26 Kai Cao,John A Brailsford,Samuel J Bonacorsi
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Studies of hydrogen isotope scrambling during the dehalogenation of aromatic chloro-compounds with deuterium gas over palladium catalysts. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-09-04 William J S Lockley,Niccolò A E Venanzi,Georgie J Crane
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Production of [68 Ga]Ga-PSMA: Comparing a manual kit-based method with a module-based automated synthesis approach. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-08-31 Janke Kleynhans,Sietske Rubow,Jannie le Roux,Biljana Marjanovic-Painter,Jan Rijn Zeevaart,Thomas Ebenhan
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Synthesis of a Deuterated 6-AmHap Internal Standard for the Determination of Hapten Density in a Heroin Vaccine Drug Product. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-09-02 Mariia Makarova,Rodell C Barrientos,Oscar B Torres,Gary R Matyas,Arthur E Jacobson,Agnieszka Sulima,Kenner C Rice
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Production of the next‐generation positron nuclide zirconium‐89 (89Zr) guided by Monte Carlo simulation and its good quality for antibody labeling J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-17 Feng Wang; Jin Ding; Xiaoyi Guo; Teli Liu; Lixin Ding; Lei Xia; Hua Zhu; Zhi Yang
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A highly reproducible method for the measurement of [6‐O‐methyl‐11C]diprenorphine and its radio‐metabolites based on solid‐phase extraction and radio‐high‐pressure liquid chromatography J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-16 Michael Fairclough; Adam McMahon; Elizabeth Barnett; Julian Matthews; Christopher A. Brown; Anthony Jones
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Facile synthesis of 2‐deoxy‐2‐[18F]fluorosorbitol using sodium borohydride on aluminum oxide J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-16 Koki Hasegawa; Kazuhiro Koshino; Takahiro Higuchi
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Synthesis of 13C‐labelled cutin and suberin monomeric dicarboxylic acids of the general formula HO213C‐(CH2)n‐13CO2H (n = 10, 12, 14, 16, 18, 20, 22, 24, 26, 28) J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-16 Carina Schink; Sandra Spielvogel; Wolfgang Imhof
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Dual‐labeled prostate‐specific membrane antigen (PSMA)‐targeting agent for preoperative molecular imaging and fluorescence‐guided surgery for prostate cancer J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-10 Myoung Hyoun Kim; Seul‐Gi Kim; Dae‐Weung Kim
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-10-05
No abstract is available for this article.
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Thorium chelators for targeted alpha therapy: Rapid chelation of thorium-226. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-08-18 Maryline G Ferrier,Yawen Li,Ming-Kuan Chyan,Roger Wong,Lily Li,Sarah Spreckelmeyer,Donald K Hamlin,Tara Mastren,Michael E Fassbender,Chris Orvig,D Scott Wilbur
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Study of the 99mTc‐labeling conditions of 6‐hydrazinonicotinamide‐conjugated peptides from a new perspective: Introduction to the term radio‐stoichiometry J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-09-30 Sajad Kaihani; Nourollah Sadeghzadeh
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Synthesis of 18 F-radiolabeled organophosphine fluorides for thiol-chemoselective peptide conjugation. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-09-19 Huanglan Zhuang,Zhide Guo,Rongqiang Zhuang,Xianzhong Zhang
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-09-13
No abstract is available for this article.
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Enantioselective synthesis of tri-deuterated (-)-geosmin to be used as internal standard in quantitation assays. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-28 Caterina Porcelli,Johanna Kreissl,Martin Steinhaus
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Radiosynthesis of a Bruton's tyrosine kinase inhibitor, [11 C]Tolebrutinib, via palladium-NiXantphos-mediated carbonylation. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-29 Kenneth Dahl,Timothy Turner,Neil Vasdev
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Radiolabeled hormones in insulin research, a minireview. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-09-09 J Jiráček,L Žáková,A Marek
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Carbon-13 synthesis and NMR spectroscopic geometric isomer evaluation to support the filing of teriflunomide. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-08-24 Michael Kurz,Dirk Gretzke,Rolf Hörlein,Sandrine Turpault,Jens Atzrodt,Volker Derdau
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-08-12
No abstract is available for this article.
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Iodination of CART(61-102) peptide: Preserved binding and anorexigenic activity in mice. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-17 Veronika Pražienková,Aleš Marek,Lenka Maletínská
CART (cocaine‐ and amphetamine‐regulated transcript) peptides are involved in food intake regulation, stress, and other physiological functions. Although CART peptides have been known for over 25 years, their receptor(s) have not yet been characterized. In this short review, we will summarize our previous studies, where we reported specific binding of 125I‐CART(61‐102) to PC12 rat pheochromocytoma
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Radiolabeled HOCPCA as a highly useful tool in drug discovery and pharmacology J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-20 Nane Griem‐Krey; Bente Frølund; Aleš Marek; Petrine Wellendorph
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-23
No abstract is available for this article.
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S-(4-nitrobenzyl)-6-thioinosine: Tritium labelling at high specific activity. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-23 Crist N Filer,Chang Byon
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The magic of small structure differences in a sodium-glucose cotransporter drug discovery project-14 C-labelled drug candidates in a key-differentiating study. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-07 Manfred Schudok,Heiner Glombik,Volker Derdau
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The synthesis of one H-2 labeled and two H-3 labeled leukotriene C4 synthase inhibitors. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-07 Jonas Bergare,Lee Kingston,Dominic J Guly,James Dolan,Richard J Lewis,Charles S Elmore
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Radiosynthesis, in vitro and preliminary biological evaluation of [18 F]2-amino-4-((2-((3-fluorobenzyl)oxy)benzyl)(2-((3-(fluoromethyl)benzyl)oxy)benzyl)amino)butanoic acid, a novel alanine serine cysteine transporter 2 inhibitor-based positron emission tomography tracer. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-06 Tristan Baguet,Jakob Bouton,Jonas Janssens,Glenn Pauwelyn,Jeroen Verhoeven,Benedicte Descamps,Serge Van Calenbergh,Christian Vanhove,Filip De Vos
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Synthesis of C-14 labeled Rac-(3R,2S)-glycopyrronium bromide. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-01 Jonas Bergare,Neil Nixon,Jeffery Newsome,Linda Thunberg,Charles S Elmore
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Automated GMP production and long-term experience in radiosynthesis of CB1 tracer [18 F]FMPEP-d2. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-07-01 Salla Lahdenpohja,Thomas Keller,Sarita Forsback,Tapio Viljanen,Esa Kokkomäki,Riikka V Kivelä,Jörgen Bergman,Olof Solin,Anna K Kirjavainen
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New synthesis of 6″-[18 F]fluoromaltotriose for positron emission tomography imaging of bacterial infection. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-06-29 Moustafa T Gabr,Tom Haywood,Gayatri Gowrishankar,Ananth Srinivasan,Sanjiv S Gambhir
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Development of a fully automated low-pressure [11 C]CO carbonylation apparatus. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-06-25 Mélodie Ferrat,Youssef El Khoury,Peter Larsen,Kenneth Dahl,Christer Halldin,Magnus Schou
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PET Imaging of a Novel Anxal-targeted Peptide 18 F-Al-NODA-Bn-p-SCN-GGGRDN-IF7 in A431 Cancer Mouse Models. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-06-20 Fei Chen,Yichun Xiao,Kejing Shao,Bao Zhu,Mengjun Jiang
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-06-18
No abstract is available for this article.
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A one-pot radiosynthesis of [18 F]PARPi. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-06-16 Thomas C Wilson,Nagavarakishore Pillarsetty,Thomas Reiner
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-06-05
No abstract is available for this article.
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Automated synthesis of 68 Ga/177 Lu-PSMA on the Trasis miniAllinOne. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-06-01 Mikkel A Sørensen,Valdemar L Andersen,Helle Westergren Hendel,Charles Vriamont,Corentin Warnier,Julien Masset,Tri Hien Viet Huynh
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A novel 99m Tc-diester complex as tumor targeting agent: Synthesis, radiolabeling, and biological distribution study. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-05-19 Hesham A Shamsel-Din,Mohamed A Gizawy,Elsayed G Zaki,Amr Elgendy
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-05-17
No abstract is available for this article.
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Synthesis of stable isotope-labelled firocoxib. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-05-05 Bachir Latli,Amy Gao,Valerie Kvaternick,Berhane Tecle,Scott Pennino,Nathan K Yee,Jeff Song
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-05-04
No abstract is available for this article.
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Selective synthesis of L-2-[18 F]fluoro-alpha-methylphenylalanine via copper-mediated 18 F-fluorination of (mesityl)(aryl)iodonium salt. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-04-28 Aiko Yamaguchi,Hirofumi Hanaoka,Tetsuya Higuchi,Yoshito Tsushima
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Issue Information J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-04-05
No abstract is available for this article.
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Radiosynthesis of novel N-18 F-labeled 18 F-FHex-α-l-Glu and 18 F-FHex-β-Glu. J. Label. Comp. Radiopharm. (IF 1.809) Pub Date : 2020-03-30 Fuhua Wen,Shaoyu Liu,Hui Ma,Ganghua Tang
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