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Essential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of Thymus convolutus Klokov in Turkey Z. Naturforschung C (IF 1.238) Pub Date : 2021-01-18 Selma Celen Yuceturk; Sumeyye Aydogan Turkoglu; Feray Kockar; F. Zehra Kucukbay; A. Dilek Azaz
In this study, the chemical composition, antimicrobial, antioxidant, and anticancer effects of Thymus convolutus Klokov oil and its main compound camphor were investigated. The oil was isolated from T. convolutus using hydrodistillation method, analyzed by gas chromatography/mass spectrometry (GC–MS), and 66 compounds were identified. The main component was determined as camphor at 16.6%. The antioxidant
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Safflower injection inhibits pulmonary arterial remodeling in a monocrotaline-induced pulmonary arterial hypertension rat model Z. Naturforschung C (IF 1.238) Pub Date : 2020-12-02 Aifeng Chen; Shibiao Ding; Liangliang Kong; Jianpu Xu; Fei He; Chuhui Ru; Xu’ai Lin
Pulmonary arterial hypertension (PAH) is a group of diseases with an increase of pulmonary artery pressure (PAP) and pulmonary vascular resistance. Here, the effects of safflower injection, a preparation of Chinese herbs, was investigated in a monocrotaline (MCT)-induced PAH rat model. PAP, carotid artery pressure (CAP), and the right ventricular hypertrophy index (RVHI) increased in the PAH group
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Absolute configuration of tetrandrine and isotetrandrine influences their anti-proliferation effects in human T cells via different regulation of NF-κB Z. Naturforschung C (IF 1.238) Pub Date : 2020-10-30 Wencheng Xu; Junichi Kusano; Shuhe Chen; Ryusei Yamamoto; Hiroto Matsuda; Yoshikazu Hara; Yoshiaki Fujii; Seiichi Hayashi; Sachiko Tanaka; Kentaro Sugiyama; Haruki Yamada; Toshihiko Hirano
Natural compound tetrandrine was reported to inhibit the proliferation of T cells by inhibiting activation of NF-κB. Chemically, isotetrandrine differs from tetrandrine only in the stereochemistry at the chiral centers. The present study aimed to compare their anti-proliferation effects on human T cells with a focus on NF-κB. The IC50 values of tetrandrine against MOLT-4 cells, MOLT-4/DNR cells, and
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Frontmatter Z. Naturforschung C (IF 1.238) Pub Date : 2021-01-08
Journal Name: Zeitschrift für Naturforschung C Volume: 76 Issue: 1-2 Pages: i-iii
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Cardenolides and pentacyclic triterpenes isolated from Acokanthera oblongifolia leaves: their biological activities with molecular docking study Z. Naturforschung C (IF 1.238) Pub Date : 2020-12-23 Howaida I. Abd-Alla; Maha M. Soltan; Amal Z. Hassan; Hanan A. A. Taie; Heba M. Abo-Salem; Eman A. Karam; Mounir M. El-Safty; Atef G. Hanna
Pentacyclic triterpenes and cardenolides were isolated from Acokanthera oblongifolia leaves. Their chemical structures were determined based on comprehensive 1D and 2D NMR spectroscopy. Their MIC was determined against 12 microorganisms. Their exerted cytotoxicity on the immortalized normal cells, hTERT-RPE1 was assessed by the sulforhodamine-B assay. The viral inhibitory effects of compounds against
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Cytogenetic and oxidative effects of three lichen extracts on human peripheral lymphocytes Z. Naturforschung C (IF 1.238) Pub Date : 2020-12-21 Bugrahan Emsen; Ayse Levent Kolukisa
In the present study, we investigated cytogenetic and oxidative [total antioxidant capacity (TAC), total oxidant status (TOS)] effects of methanol and water extracts of Cladonia chlorophaea (Flörke ex Sommerf.) Sprengel, Dermatocarpon miniatum (L.) W.Mann and Parmelia saxatilis (L.) Ach. on cultured human lymphocytes. In addition, different phenolic compounds in the extracts were quantified by high
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Phytochemical, antibacterial, antioxidant and cytoxicity investigation of Tarenna grandiflora Z. Naturforschung C (IF 1.238) Pub Date : 2020-12-16 Jean Francois Zeutsop; Raymond Ngansop Nono; Marcel Frese; Jean Rodolphe Chouna; Bruno Ndjakou Lenta; Pépin Nkeng-Efouet-Alango; Norbert Sewald
The phytochemical investigation of Tarenna grandiflora led to the isolation of 18 known compounds of which were four flavones, three anthraquinones, one phenyl propanoic derivative, five triterpenoids, four steroids and a mixture of glucose. Luteolin (1) and soranjidiol (6) were allylated and/or prenylated to give four new semisynthesized derivatives which were fully characterized as 7,3′,4′-O-triallylluteolin
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Cytotoxic withanolides from Datura innoxia Z. Naturforschung C (IF 1.238) Pub Date : 2020-12-10 Emma Maldonado; Teresa Ramírez-Apan; Mahinda Martínez
Chemical investigation of the aerial parts (except fruits) of the medicinal, hallucinogen and toxic plant Datura innoxia Mill. [Solanaceae] led to the isolation of the new withanolide, dinnoxolide A (1), along with the known compounds 21,27-dihydroxy-1-oxowitha-2,5,24-trienolide (2), daturamalakin B (3) and withametelin (4). Their structures were established by analysis of their spectroscopic data
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Down-regulation of SORL1 is associated with Alzheimer’s disease through activating ABC transporter pathway Z. Naturforschung C (IF 1.238) Pub Date : 2020-11-30 Zhiqiang Wei; Xingdi Qi; Shijun Zhai; Yan Chen; Xiaoshuang Xia; Boyu Zheng; Xugang Sun; Guangming Zhang; Ling Wang; Qi Zhang; Chen Xu; Shihe Jiang; Xiulian Li; Bingxin Xie; Xiaohui Liao; Zhu Ai; Xin Li
Alzheimer’s disease (AD) is a common neurodegenerative disease with high morbidity among elderly people. A genetic attribution has been extensively proved. Here, we propose to further prioritize genes that harbor single nucleotide variation (SNV) or structural variation (SV) for AD and explore the underlying potential mechanisms through exploiting their expression and methylation spectra. A high-confidence
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Book Review Z. Naturforschung C (IF 1.238) Pub Date : 2020-11-27 Edmund C.M. Tse; Hongzhe Sun
Journal Name: Zeitschrift für Naturforschung C Volume: -1 Issue: ahead-of-print Pages: 455
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Chemical composition, antioxidant and antimicrobial activity of essential oils from tangerine (Citrus reticulata L.), grapefruit (Citrus paradisi L.), lemon (Citrus lemon L.) and cinnamon (Cinnamomum zeylanicum Blume) Z. Naturforschung C (IF 1.238) Pub Date : 2020-11-20 Rositsa Denkova-Kostova; Desislava Teneva; Teodora Tomova; Bogdan Goranov; Zapryana Denkova; Vesela Shopska; Aleksandar Slavchev; Yana Hristova-Ivanova
The phytochemical and biological properties of tangerine (Citrus reticulata L.), grapefruit (Citrus paradisi L.), lemon (Citrus lemon L.) and cinnamon (Cinnamomum zeylanicum Blume) essential oils were examined. The chemical composition of the essential oils determined using chromatography analysis revealed that D-limonene and cis-cinnamaldehyde were the main components. The antioxidant and antimicrobial
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Chemical characterization of Goniothalamus macrophyllus and Goniothalamus malayanus leaves' essential oils. Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-23 Natasa Mohd Shakri,Wan Mohd Nuzul Hakimi Wan Salleh,Shamsul Khamis,Nor Azah Mohamad Ali
This study was aimed to investigate the chemical compositions of the essential oils from Goniothalamus macrophyllus and Goniothalamus malayanus growing in Malaysia. The essential oils were obtained by hydrodistillation and fully characterized by gas chromatography (GC–FID) and gas chromatography–mass spectrometry (GC–MS). Analyses of the essential oils from G. macrophyllus and G. malayanus resulted
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Composition of the essential oils of three Malaysian Xylopia species (Annonaceae). Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-22 Natasa Mohd Shakri,Wan Mohd Nuzul Hakimi Wan Salleh,Shamsul Khamis,Nor Azah Mohamad Ali,Muhammad Helmi Nadri
The rich and diversified Malaysian flora represents an excellent resource of new chemical structures with biological activities. The genus Xylopia L. includes aromatic plants that have both nutritional and medicinal uses. This study aims to contribute with information about the volatile components of three Xylopia species essential oils: Xylopia frutescens, Xylopia ferruginea, and Xylopia magna. In
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Dynamic analysis of the mathematical model of COVID-19 with demographic effects. Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-13 Naeem Faraz,Yasir Khan,E F Doungmo Goufo,Amna Anjum,Ali Anjum
The coronavirus is currently extremely contagious for humankind, which is a zoonotic tropical disease. The pandemic is the largest in history, affecting almost the whole world. What makes the condition the worst of all is no specific effective treatment available. In this article, we present an extended and modified form of SIR and SEIR model, respectively. We begin by investigating a simple mathematical
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Frontmatter Z. Naturforschung C (IF 1.238) Pub Date : 2020-11-05
Journal Name: Zeitschrift für Naturforschung C Volume: 75 Issue: 11-12 Pages: i-iv
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Ultra-high-performance liquid chromatography – high-resolution mass spectrometry profiling and hepatoprotective activity of purified saponin and flavonoid fractions from the aerial parts of wild spinach (Chenopodium bonus-henricus L.) Z. Naturforschung C (IF 1.238) Pub Date : 2020-11-03 Zlatina Kokanova-Nedialkova; Paraskev Nedialkov; Magdalena Kondeva-Burdina
An ultra-high-performance liquid chromatography – high-resolution mass spectrometry profiling method was used for a comprehensive study of flavonoid and saponin-rich fractions from the aerial parts of wild spinach (Chenopodium bonus-henricus L.). Thirty-six compounds, respectively, 22 saponins of eight sapogenins (phytolaccagenin, bayogenin, medicagenic acid, 2β-hydroxygypsogenin, 2β-hydroxyoleanoic
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Purification of a Src family tyrosine protein kinase from bovine retinas Z. Naturforschung C (IF 1.238) Pub Date : 2020-11-02 Deisy Perdomo; José Bubis
Since tyrosine phosphorylation appears to play important functions in photoreceptor cells, we searched here for retinal nonreceptor tyrosine kinases of the Src family. We demonstrated that Src family tyrosine kinases were present in the cytosolic fraction of extracted bovine retinas. A Src family tyrosine kinase with an apparent molecular mass of about 62 kDa was purified to homogeneity from the soluble
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Synergistic antibacterial combination of Lavandula latifolia Medik. essential oil with camphor Z. Naturforschung C (IF 1.238) Pub Date : 2020-11-02 Nursenem Karaca; Görkem Şener; Betül Demirci; Fatih Demirci
Combination of various compounds and essential oils for pharmaceutical formulations withdraw attention. In this present study, it was aimed to evaluate the in vitro potential synergistic antibacterial effect of Lavandula latifolia (spike lavender) essential oil with camphor by using the checkerboard method against the human pathogens; Staphylococcus aureus and Listeria monocytogenes. Pharmacopoeia
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Potential insecticidal activity of aminonaphthoquinone Mannich bases derived from lawsone and their copper (II) complex derivatives Z. Naturforschung C (IF 1.238) Pub Date : 2020-10-12 Andréia P. Matos; André L. F. Sarria; Ana C. Volante; Antônio R. Bernardo; Gracielle O. S. Cunha; João B. Fernandes; Paulo C. Vieira; Maria Fátima das G. F. da Silva
The fall armyworm, Spodoptera frugiperda, is a polyphagous pest that causes important damage in different regions of America and mainly affects corn crops in both tropical and subtropical areas. Currently, control relies on both transgenic plants and/or chemical pesticides. In this work, we describe insecticidal activity against the fall armyworm from a series of Mannich bases (1–10), derived from
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Structural elucidation and neuroprotective activities of lignans from the flower buds of Magnolia biondii Pamp. Z. Naturforschung C (IF 1.238) Pub Date : 2020-10-26 Qinge Ma; Rongrui Wei; Xiaodong Zhang; Zhipei Sang; Jianghong Dong
Two new lignans, 3,4-(10-methoxy-phenylallyl)-9″-((10′-isopropanol-3′,4′-furan)-phenylacetyl)-8″-dioxane-7″-O-β-d-glucopyranoside (1), 3,4-benzolactone-9″-((12′-isopropanol-3′,4′-furan)-phenylbutenone)-8″-dioxane-7″-O-β-d-glucopyranoside (2), and nine known lignan derivatives (3–11) were isolated from the flower buds of Magnolia biondii Pamp. for the first time. Their structures were elucidated by
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Elaeocarpus floribundus Bl. seeds as a new source of bioactive compounds with promising antioxidant and antimicrobial properties Z. Naturforschung C (IF 1.238) Pub Date : 2020-10-15 Ayorinde V. Ogundele; Saikat Haldar; Archana Yadav; Archana M. Das
The fruits of Elaeocarpus floribundus Bl. (Elaeocarpaceae) are edible and are normally prescribed for treatment of diseases. The medicinal uses of the fruit create considerable quantities of seeds as wastes. In an attempt to valorise this biomass, we studied the antimicrobial and antioxidant activities of the ethanolic seed extract. The extract inhibited the growth of the tested pathogens and was also
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Root essential oil of Chrysopogon zizanioides relaxes rat isolated thoracic aorta – an ex vivo approach Z. Naturforschung C (IF 1.238) Pub Date : 2020-10-14 Lekha Sivakumar; David Raj Chellappan; Venkatraman Sriramavaratharajan; Ramar Murugan
Root of Chrysopogon zizanioides (L.) Roberty has been used in Siddha system of medicine to treat hypertension. The present study was therefore to investigate the vasorelaxation effect of root essential oil of C. zizanioides using rat isolated thoracic aortic rings. Chemical characterization of root essential oil was carried out using Gas Chromatography–Flame Ionization Detector (GC–FID) and Gas Chromatography–Mass
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Ethyl acetate extract from Cistus x incanus L. leaves enriched in myricetin and quercetin derivatives, inhibits inflammatory mediators and activates Nrf2/HO-1 pathway in LPS-stimulated RAW 264.7 macrophages Z. Naturforschung C (IF 1.238) Pub Date : 2020-10-06 Mario D’Ambrosio; Elisabetta Bigagli; Lorenzo Cinci; Antonella Gori; Cecilia Brunetti; Francesco Ferrini; Cristina Luceri
Cistus x incanus L. is a Mediterranean evergreen shrub used in folk medicine for the treatment of inflammatory disorders but the underlying mechanisms are not fully understood. We therefore investigated the anti-inflammatory effects of an ethyl acetate fraction (EAF) from C. x incanus L. leaves on lipopolysaccharide (LPS) activated RAW 264.7 macrophages. HPLC analysis revealed myricetin and quercetin
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Distillation time effecting on the composition of Origanum floribundum essential oils and their antioxidant and antimicrobial activities Z. Naturforschung C (IF 1.238) Pub Date : 2020-10-01 Lamia Kerbouche; Mohamed Hazzit; Aoumeur Baaliouamer; Soraya Akretche
The essential oils (EOs) of Origanum floribundum Munby, an aromatic and medicinal plant endemic in Algeria, were extracted by different hydrodistillation times (30 min, 1, 2 and 3 h) and analyzed by GC and GC–MS. The chromatographic analysis showed that thymol (32.7–45.0%), p-cymene (16.8–23.1%) and γ-terpinene (21.6–28.7%) were the most prominent components of the oils. The antioxidant ability was
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Design and synthesis of novel n-butyphthalide derivatives as promising botanical fungicides Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-25 Zhongfu Luo; Yu Deng; Bilan Luo; Yong Li; Qing Lan; Judi Fan; Wei Xue; Lei Tang; Lingling Fan
In order to obtain novel botanical fungicides, three series of novel 6-substituted n-butyphthalide derivatives have been designed and synthesized via nucleophilic addition, reduction, nitrification, amination, sulfonation, Sandmeyer and Suzuki reaction. The mycelium growth rate method was used to evaluate the inhibition activity against eight phytopathogenic fungi in vitro. Preliminary bioassay tests
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Neuroprotective constituents of Actaea acuminata (Wall. ex Royle) H. Hara roots Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-28 Deepak Kumar; Suresh Kumar
The methanol extract and its ethyl acetate fraction (EAF) of Actaea acuminata (Wall. ex. Royle) H. Hara roots were reported to exhibit significant antianxiety, anticonvulsant and antidepressant activities, and mild sedative activity. But the constituents responsible for these activities have not been isolated. The present study was undertaken to isolate neuroprotective compounds of A. acuminata following
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Inhibition of chikusetsusaponin IVa on inflammatory responses in RAW264.7 cell line via MAPK pathway Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-28 Guangren Xu; Hongyu Lei; Qiaoling Yuan; Huiyu Chen; Jianming Su
Chikusetsusaponin IVa (CHS-IVa), a saponin from herb Panacis japonicas, possesses extensive biological activities. However, the roles and underlying mechanisms of CHS-IVa on inflammation have not been fully clarified in the setting of murine macrophages. In this study, we found that CHS-IVa effectively reduced the expression of inflammatory mediators, including interleukin-6 (IL-6), tumor necrosis
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Cotinus coggygria Scop. induces cell cycle arrest, apoptosis, genotoxic effects, thermodynamic and epigenetic events in MCF7 breast cancer cells. Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-25 Zlatina I Gospodinova,Istvan Zupkó,Noémi Bózsity,Vasilissa I Manova,Mariyana S Georgieva,Svetla J Todinova,Stefka G Taneva,Imre Ocsovszki,Maria E Krasteva
Current plant-derived anticancer therapeutics aim to reach higher effectiveness, to potentiate chemosensitivity and minimize the toxic side effects compared to conventional chemotherapy. Cotinus coggygria Scop. is a herb with high pharmacological potential, widely applied in traditional phytotherapy. Our previous study revealed that leaf aqueous ethanolic extract from C. coggygria exerts in vitro anticancer
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A systematic review of botany, phytochemicals and pharmacological properties of "Hoja sant a" (Piper auritum Kunth). Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-21 Wan Mohd Nuzul Hakimi Wan Salleh
Hoja santa (Piper auritum) refers to an important presence in Mexican cuisine. The information of this review article was gathered from several electronic sources such as Scopus, Medline, Scielo, ScienceDirect, SciFinder, Web of Science, Google Scholar and Lilacs. Phytochemical studies have revealed the presence of benzoic acid derivatives, phenylpropanoids and triterpenoids, while the essential oils
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Synthesis, investigation of biological effects and in silico studies of new benzimidazole derivatives as aromatase inhibitors. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-20 Begüm Nurpelin Sağlık,Ahmet Mücahit Şen,Asaf Evrim Evren,Ulviye Acar Çevik,Derya Osmaniye,Betül Kaya Çavuşoğlu,Serkan Levent,Abdullah Burak Karaduman,Yusuf Özkay,Zafer Asım Kaplancıklı
Inhibition of aromatase enzymes is very important in the prevention of estrogen-related diseases and the regulation of estrogen levels. Aromatase enzyme is involved in the final stage of the biosynthesis of estrogen, in the conversion of androgens to estrogen. The development of new compounds for the inhibition of aromatase enzymes is an important area for medicinal chemists in this respect. In the
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Frontmatter Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-15
Journal Name: Zeitschrift für Naturforschung C Volume: 75 Issue: 9-10 Pages: i-iii
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A new xanthone dimer and cytotoxicity from the stem bark of Calophyllum canum. Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-15 Muhammad Taher,Wan Mohd Nuzul Hakimi Wan Salleh,Suhaib Ibrahim Alkhamaiseh,Farediah Ahmad,Mohamad Fazlin Rezali,Deny Susanti,Choudhury Mahmood Hasan
A phytochemical investigation of the stem bark of Calophyllum canum resulted in the isolation of a new xanthone dimer identified as biscaloxanthone (1), together with four compounds; trapezifoliaxanthone (2), trapezifolixanthone A (3), taraxerone (4) and taraxerol (5). The structures of these compounds were determined via spectroscopic methods of IR, UV, MS and NMR (1D and 2D). The cytotoxicity of
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Monitoring of changes in 5-n-alkylresorcinols during wheat seedling development. Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-14 Elżbieta G Magnucka,Małgorzata P Oksińska,Stanisław J Pietr
For seven days of wheat growth, caryopsis remained the main source of 5-n-alkylresorcinols with C19 and/or C21 homolog as a main compound. Shoot contained small amount of these phenolic lipids; their average content was 3.23% of level obtained in the whole seedling. Moreover, 41.38% of resorcinolic lipids of seven-day-old shoot was accumulated in part of leaf covered by coleoptile. Interestingly, a
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Coumaronochromone as antibacterial and carbonic anhydrase inhibitors from Aerva persica (Burm.f.) Merr.: experimental and first-principles approaches. Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-09 Muhammad Imran,Ahmad Irfan,Mohammed A Assiri,Sajjad H Sumrra,Muhammad Saleem,Riaz Hussain,Abdullah G Al-Sehemi
The Aerva plants are exceptionally rich in phytochemicals and possess therapeutics potential. Phytochemical screening shows that Aerva persica (Burm.f.) Merr. contains highest contents i.e., total phenolics, flavonoids, flavonols, tannins, alkaloids, carbohydrates, anthraquinones and glycosides. In-vitro antibacterial and enzymatic (carbonic anhydrase) inhibition studies on methanol extracts of A. persica
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Anticancer effects of novel NSAIDs derivatives on cultured human glioblastoma cells. Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-04 Özlem Özdemir,Lisa Marinelli,Ivana Cacciatore,Michele Ciulla,Bugrahan Emsen,Antonio Di Stefano,Adil Mardinoglu,Hasan Turkez
Several epidemiologic, clinical and experimental reports indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) could have a potential as anticancer agents. The aim of this study was the evaluation of cytotoxic potential in human glioblastoma cells of novel synthesized NSAID derivatives, obtained by linking, through a spacer, α-lipoic acid (ALA) to anti-inflammatory drugs, such as naproxen (AL-3
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Phytochemical characterization of different yarrow species (Achillea sp.) and investigations into their antimicrobial activity. Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-07 Lysanne Apel,Peter Lorenz,Sabine Urban,Simon Sauer,Otmar Spring,Florian C Stintzing,Dietmar R Kammerer
Various Achillea species are rich in bioactive compounds and are important medicinal plants in phytotherapy. In the present study, Achillea millefolium L., Achillea moschata Wulfen, and Achillea atrata L. were compared with respect to their phenolic profile and antibacterial activity against gram-positive bacteria strains (Staphylococcus, Propionibacterium). Particular focus was given to A. atrata
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The fate of chlorophyll in phytophagous insects goes beyond nutrition. Z. Naturforschung C (IF 1.238) Pub Date : 2020-09-04 Vincensius S P Oetama,Stefan Pentzold,Wilhelm Boland
Chlorophyll (Chl) is a natural compound that is found in all autotrophic plants. Since phytophagous insects ingest the photosynthetically active material with the plant leaves, the question arises if and how herbivores deal with Chl and its degradation products. Here we review findings on Chl degradation in phytophagous insects and highlight the role of these ubiquitous plant metabolites for plant-feeding
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Effect of pH on xylitol production by Candida species from a prairie cordgrass hydrolysate. Z. Naturforschung C (IF 1.238) Pub Date : 2020-08-21 Samatha S R Rudrangi,Thomas P West
Using hydrolysates of the North American prairie grass prairie cordgrass buffered at pH 4.5, 5.0, 5.5 or 6.0, xylitol production, xylitol yield, cell biomass production and productivity were investigated for three strains of yeast Candida. Of the three strains, the highest xylitol concentration of 20.19 g xylitol (g xylose consumed)−1 and yield of 0.89 g xylitol (g xylose consumed)−1 were produced
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Metabolite profiling by means of GC-MS combined with principal component analyses of natural populations of Nectaroscordum siculum ssp. bulgaricum (Janka) Stearn. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-24 Radka Z Vrancheva,Ivayla N Dincheva,Ina Y Aneva,Atanas I Pavlov
Nectaroscordum siculum ssp. bulgaricum (Janka) Stearn (Allium siculum subsp. dioscoridis (Sm.) K. Richt.) is a traditional culinary spice from South-East Europe. Studies of N. siculum have focused mainly on the botanical and taxonomic characteristics of this species and there is no data available in the scientific literature about its metabolite profile. Thus, the aim of the current study was metabolite
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Essential oil composition of three Cryptocarya species from Malaysia. Z. Naturforschung C (IF 1.238) Pub Date : 2020-05-26 Muhammad Ammar Mohd Azhar,Wan Mohd Nuzul Hakimi Wan Salleh,Shamsul Khamis
Cryptocarya species are mainly distributed in Africa, Asia, Australia and South America, widely used in traditional medicines for the treatment of skin infections and diarrhea. The present investigation reports on the extraction by hydrodistillation and the chemical composition of three Cryptocarya species (Cryptocarya impressa, Cryptocarya infectoria, and Cryptocarya rugulosa) essential oils from
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Toxicology study of fraxinellone as ovicidal agents against Mythimna separata Walker and Bombyx mori Linaeus. Z. Naturforschung C (IF 1.238) Pub Date : 2020-06-22 Min Lv,Suying Chen,Shaoyong Zhang,Hui Xu
Fraxinellone is a naturally occurring degraded limonoid isolated from many species of plants in Meliaceae and Rutaceae. Besides structural modification of the lead compounds, the toxicology study of the lead compounds is also a very important procedure to develop insecticidal agents. Herein the toxicology study of fraxinellone was carried out as the ovicidal agent against the eggs of two lepidopteran
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Bergamot essential oil nanoemulsions: antimicrobial and cytotoxic activity. Z. Naturforschung C (IF 1.238) Pub Date : 2020-06-22 Enrico Marchese,Nunzia D'onofrio,Maria Luisa Balestrieri,Domenico Castaldo,Giovanna Ferrari,Francesco Donsì
Bergamot essential oil (BEO) is well-known for its food preservation activity, as well as anticancer efficacy. However, the poor BEO water solubility and deriving low bioaccessibility have limited its wider applications. The incorporation in nanoemulsions of BEO and its refined fractions was investigated to enhance its dispersibility in water to promote its antimicrobial activity, tested against Escherichia
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Helichrysum araxinum Takht. ex Kirp. grown in Italy: volatiloma composition and in vitro antimicrobial activity. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-02 Basma Najar,Valeria Nardi,Claudio Cervelli,Francesca Mancianti,Simona Nardoni,Valentina Virginia Ebani,Luisa Pistelli
In the present work the composition of biogenic volatile organic compounds (BVOCs) and the essential oil (EO) of Helichrysum araxinum Takht. ex Kirp. aerial parts, together with the antimicrobial activity, were investigated. The results showed the prevalence of sesquiterpene hydrocarbons in both spontaneous emissions as well as in the EO. The main compounds of BVOCs were γ-curcumene (10.7%), γ-muurolene
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Selected essential oils and their mechanisms for therapeutic use against public health disorders. An overview. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-06 Ingrid Leherbauer,Iris Stappen
Today, the numbers of people suffering from lifestyle diseases like diabetes, obesity, allergies and depression increases mainly in industrialised states. That does not only lower patients’ quality of life but also severely stresses the health care systems of these countries. Essential oils (EO) have been in use as therapeutic remedies for centuries against various complaints, but still their effectiveness
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Essential oils. Z. Naturforschung C (IF 1.238) Pub Date : 2020-06-30 Klaus H Hoffmann
Journal Name: Zeitschrift für Naturforschung C Volume: 75 Issue: 7-8 Pages: 177-177
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Frontmatter Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-20
Journal Name: Zeitschrift für Naturforschung C Volume: 75 Issue: 7-8 Pages: i-iii
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Isolation of secondary metabolites from the Iranian medicinal plant Eremurus persicus. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-20 Javad Mottaghipisheh,Norbert Kúsz,Judit Hohmann,Yu-Chi Tsai,Dezső Csupor
Eremurus persicus (Jaub. & Spach) Boiss. belonging to Xanthorrhoeaceae family is an endemic medicinal plant widely distributed in Iran. Its leaves have been traditionally used as a food and also as medicinal plant. Regarding the widespread application of E. persicus in Iranian folk medicine, and the insignificant investigation of its components, this study aimed at the isolation and identification
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A computational study of the interactions between anthocyans and cyclodextrins. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-20 Raluca Pop,Adina Căta,Mariana Nela Ștefănuț,Ioana Maria Carmen Ienașcu
The interactions between six anthocyans (cyanidin-3-O-glucoside, delphinidin-3-O-glucoside, malvidin-3-O-glucoside, cyanidin-3-O-rutinoside, delphinidin-3-O-rutinoside, malvidin-3-O-rutinoside) and cyclodextrins were investigated by means of computational techniques. Four different structures of the aforementioned anthocyans were considered, as a result of the dependence structure – pH value (flavylium
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Decumbic anhydride from the stem barks of Swintonia floribunda (Anacardiaceae). Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-16 Phu Hoang Dang,Tho Huu Le,Truong Nhat Van Do,Hai Xuan Nguyen,Mai Thanh Thi Nguyen,Nhan Trung Nguyen
From an EtOAc-soluble fraction of the stem barks of Swintonia floribunda (Anacardiaceae), decumbic anhydride (1) and four known compounds 2–5 were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The GIAO-DFT calculation of 13C NMR chemical shifts was carried out to clarify the structure of 1. The absolute configuration of 1 was assigned based on the
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Gas chromatography coupled to mass spectrometry (GC-MS) characterization and evaluation of antibacterial bioactivities of the essential oils from Piper arboreum Aubl., Piper aduncum L. e Piper gaudichaudianum Kunth. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-16 Ana Cristina A da Silva,Edinardo F F Matias,Janaína E Rocha,Ana Carolina Justino de Araújo,Thiago S de Freitas,Fábia F Campina,Maria do S Costa,Luiz E Silva,Wanderlei do Amaral,Beatriz Helena L N S Maia,Aurea P Ferriani,Camila F Bezerra,Marcello Iriti,Henrique D M Coutinho
The objective of this study was to determine the chemical profile and to evaluate the antibacterial activity of the essential oils of Piper species and modulation of the antibiotic activity, using the microdilution method to determine the minimum inhibitory concentration. The chemical components were characterized by gas chromatography coupled to mass spectrometry, which revealed β-copaen-4-α-ol (31
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Modulation of antibiotic resistance by the essential oil of Ocimum gratissimum L. in association with light-emitting diodes (LED) lights. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-06 Maria Karollyna do N Silva Leandro,Janaína E Rocha,Camila F Bezerra,Priscilla R Freitas,Jessica Horana F Feitosa,Viviane B Bezerra,Rizelle de O Barros,Livia Maria G Leandro,José Junior Dos S Aguiar,Paulo S Pereira,Marcela Christofoli,Jaime Ribeiro-Filho,Marcello Iriti,Henrique Douglas M Coutinho,Edinardo Fagner F Matias
This study aimed to evaluate the antibacterial and antibiotic-enhancing effects of the essential oil obtained from Ocimum gratissimum L. (OEOg) alone or in association with light-emitting diodes (LED) lights. The essential oil was obtained by hydrodistillation and its chemical composition analysed by gas chromatography coupled to mass spectrometry. The antibacterial and antibiotic-enhancing activities
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Chemical composition of the essential oils of four Polyalthia species from Malaysia. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-06 Natasa Mohd Shakri,Wan Mohd Nuzul Hakimi Wan Salleh,Shamsul Khamis,Nor Azah Mohamad Ali,Shazlyn Milleana Shaharudin
Polyalthia is one of the largest genera in the Annonaceae family, and has been widely used in folk medicine for the treatment of rheumatic fever, gastrointestinal ulcer, and generalized body pain. The present investigation reports on the extraction by hydrodistillation and the composition of the essential oils of four Polyalthia species (P. sumatrana, P. stenopetalla, P. cauliflora, and P. rumphii)
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Coronaviruses widespread on nonliving surfaces: important questions and promising answers. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-05 Mohamed A Deyab
The world is facing, while writing this review, a global pandemic due to one of the types of the coronaviruses (i.e., COVID-19), which is a new virus. Among the most important reasons for the transmission of infection between humans is the presence of this virus active on the surfaces and materials. Here, we addressed important questions such as do coronaviruses remain active on the inanimate surfaces
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Eleven isoquinoline alkaloids on inhibiting tissue factor activity: structure-activity relationships and molecular docking. Z. Naturforschung C (IF 1.238) Pub Date : 2020-07-03 Xuhua He,Yongjiang Zeng,Wenwen Jiang
Tissue factor (TF) which plays a key role in hemostasis and thrombosis appears to be an attractive target and medicinal plants having alkaloids inhibition TF activity benefit to cardiovascular disease (CVD). The aim of study is to explore further knowledge about alkaloids and TF. TF procoagulant activities were determined by the simplified chromogenic assay and their mRNA expression were then examined
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Biochemical evidences for M1-, M17- and M18-like aminopeptidases in marine invertebrates from Cuban coastline. Z. Naturforschung C (IF 1.238) Pub Date : 2020-06-30 Isel Pascual Alonso,Laura Rivera Méndez,Mario E Valdés-Tresanco,Lotfi Bounaadja,Marjorie Schmitt,Yarini Arrebola Sánchez,Luis Alvarez Lajonchere,Jean-Louis Charli,Isabelle Florent
Metallo-aminopeptidases (mAPs) control many physiological processes. They are classified in different families according to structural similarities. Neutral mAPs catalyze the cleavage of neutral amino acids from the N-terminus of proteins or peptide substrates; they need one or two metallic cofactors in their active site. Information about marine invertebrate’s neutral mAPs properties is scarce; available
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human monoamine oxidase (hMAO) A and hMAO B inhibitors from Artemisia dracunculus L. herniarin and skimmin: human mononamine oxidase A and B inhibitors from A. dracunculus L. Z. Naturforschung C (IF 1.238) Pub Date : 2020-06-29 Tuba Aydin,Hulya Akincioglu,Mehmet Gumustas,Ilhami Gulcin,Cavit Kazaz,Ahmet Cakir
The aim of this study was to investigate the effects of extracts and pure Artemisia dracunculus L. (tarragon) metabolites on the antimonoamine oxidase and anticholinesterase activities. The compounds were characterized as stigmasterol (1), herniarin (2), (2E,4E)-1-(piperidin-1-yl)undeca-2,4-diene-8,10-diyn-1-one (3), (2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide (4), 3,4-dehydroherniarin (5) and
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Chemical characterization of the lipids in femoral gland secretions of wild male tegu lizards, Salvator merianae (Squamata, Teiidae) in comparison with captive-bred males. Z. Naturforschung C (IF 1.238) Pub Date : 2020-06-29 Carolina N Ramiro,José Martín,Pedro Ismael da Silva Junior,Hugo B A Pinto,Arnaldo José C Magalhães Júnior,Carlos Abrahão,Miguel T Rodrigues
Although chemical interactions play an essential role in lizard social behavior, the chemical composition of the femoral gland secretions that many lizards use for communication is known for only a few species, mainly European Lacertids. The tegu lizard, Salvator merianae, is the only species of the Teiidae family for which there is available information on lipids in femoral secretions, but only for
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Overexpression of a novel E3 ubiquitin ligase gene from Coptis chinensis Franch enhances drought tolerance in transgenic tobacco. Z. Naturforschung C (IF 1.238) Pub Date : 2020-06-25 Hanting Chen,Junjun Li,Yang He
Drought stress has a significant effect on the growth, physiology and biochemistry of medicinal plants. SDIR1 (Salt- and Drought-Induced Ring Finger1), a C3H2C3-type RING-finger E3 ubiquitin ligase gene plays an important role in the stress response of various plants. However, the role of this gene is not clear in Coptis chinensis. In this study, the CcSDIR1 gene was cloned from C. chinensis using
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Topiroxostat ameliorates oxidative stress and inflammation in sepsis-induced lung injury. Z. Naturforschung C (IF 1.238) Pub Date : 2020-06-25 Haiying Fu,Junjie Zhang,Mayu Huang
Sepsis-induced lung injury was the most common cause of death in patients. Topiroxostat, a novel xanthine oxidoreductase inhibitors, possessed obvious organ protectives effects. Xanthine oxidase played a vital role in acute lung injury. The study aimed to investigate the roles of Topiroxostat in sepsis-induced lung injury. The sepsis rats were established using cecum ligation and perforation. The lung
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Synthesis of sandwich type acyclic tetra-nuclear silver(I)-N-heterocyclic carbene complexes for wound healing applications. Z. Naturforschung C (IF 1.238) Pub Date : 2020-06-25 Ayesha Riaz,Muhammad Adnan Iqbal,Haq Nawaz Bhatti,Muhammad Shahid
Two meta-xylyl linked tetrakis-benzimidazolium salts (L1-L2) as multidentate ligands and two respective silver complexes (C1 and C2) were synthesized. A multistep reaction was done at room temperature, starting with simple benzimidazole and alkyl halides, going through precursors and salt formation by reflux and finally in situ deprotonation of tetrabenzimidazolium salts with Ag2O to yield respective
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