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In vitro inhibition potency of malononitrile derivatives on the activity of two pentose phosphate pathway enzymes: accompanied by molecular docking evaluation Z. Naturforschung C (IF 2.0) Pub Date : 2024-03-18 Arzu Öztürk Kesebir, Ziya Dağalan, Pınar Güller, Bilal Nişancı, Ömer İrfan Küfrevioğlu
Many disorders, including cancer and malaria, could be targeted via the pentose phosphate pathway (PPP), whose products are key in biosynthetic reactions in cells. The goal of this study was to find new PPP inhibitors. The inhibition effects of malononitrile derivatives on Glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were analyzed through in vitro experiments
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Chitosan in cancer therapy: a dual role as a therapeutic agent and drug delivery system Z. Naturforschung C (IF 2.0) Pub Date : 2024-03-13 Harika Atmaca, Ferdi Oguz, Suleyman Ilhan
Although chemotherapy is still the most preferred treatment for cancer, most chemotherapeutic agents target both cancer cells and healthy cells and cause serious side effects due to high toxicity. Improved drug delivery systems (DDSs), which enhance the efficacy of current chemotherapeutic drugs while reducing their toxicity, offer potential solutions to these challenges. Chitosan (CS) and its derivatives
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Chemical composition, antifungal, antibiofilm, and molecular docking studies of Syzygium dyerianum essential oil Z. Naturforschung C (IF 2.0) Pub Date : 2024-03-08 Faezatul Alwani Mohd Rahim, Wan Mohd Nuzul Hakimi Wan Salleh, Mohd Hafiz Arzmi, Abubakar Siddiq Salihu
The current study describes the chemical composition, antifungal, antibiofilm, antibacterial and molecular docking studies of Syzygium dyerianum growing in Malaysia. The essential oil was obtained through hydrodistillation and characterized using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The antifungal and antibacterial activities were developed using the broth microdilution
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Isolation, structural elucidation, and biological activity of a novel isocoumarin from the dark septate endophytic fungus Phialocephala fortinii Z. Naturforschung C (IF 2.0) Pub Date : 2024-02-29 Kei Bando, Ryoga Kushibe, Naoki Kitaoka, Yutaka Tamai, Kazuhiko Narisawa, Hideyuki Matsuura
A novel isocoumarin was isolated from the mycelia of the dark septate endophytic fungus Phialocephala fortinii. The chemical structure was determined to be 8-hydroxy-6-methoxy-3,7-dimethyl-1H-2-benzopyran-1-one based on mass spectrometry, 1H-nuclear magnetic resonance (NMR), and 13C-NMR spectroscopic analyses, including 2D-NMR experiments. The isolated compound inhibited root growth of Arabidopsis
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Synthesis and antitumor activity of model cyclopentene-[g]annelated isoindigos Z. Naturforschung C (IF 2.0) Pub Date : 2024-02-28 Mustafa M. El-Abadelah, Ahmad H. Abdullah, Jalal A. Zahra, Salim S. Sabri, Sanaa K. Bardaweel, Mutasem O. Taha
A set of cyclopenten-[g]annelated isoindigos (5a–g) has been prepared and tested for their in vitro antiproliferative activities against MCF-7 and HL60 cells. Among, the N-1-methyl-5′-nitro derivative (5g) displayed the highest activity against HL60 cells (IC50 = 67 nM) and acted as the most potent Flt3 inhibitor. Compounds 5d–g exhibited moderate activity against MCF-7 (IC50 = 50–80 μM).
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In vitro antimicrobial and antioxidant activities, essential oil composition, and in silico molecular modeling analysis of secondary metabolites from roots of Verbascum sinaiticum Z. Naturforschung C (IF 2.0) Pub Date : 2024-02-28 Getachew Tegegn, Yadessa Melaku, Muhdin Aliye, Abiy Abebe, Negera Abdissa, Asfaw Meresa, Sileshi Degu, Mo Hunsen, Ahmed A. Hussein, Milkyas Endale
Verbascum sinaiticum is locally used to treat wound, stomachache, viral infection, cancer, sunstroke fever, abdominal colic, diarrhea, hemorrhage, anthrax, and hepatitis. The objective of this study was to identify the compounds and to evaluate the antimicrobial and antioxidant activity of the extracts and isolated compounds from V. sinaiticum. The 1H-NMR, 13C-NMR, and DEPT-135 were used to elucidate
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Analysis of the SARS-CoV-2 nsp12 P323L/A529V mutations: coeffect in the transiently peaking lineage C.36.3 on protein structure and response to treatment in Egyptian records Z. Naturforschung C (IF 2.0) Pub Date : 2024-01-23 Dina N. Abd-Elshafy, Rola Nadeem, Mohamed H. Nasraa, Mahmoud M. Bahgat
SARS-CoV-2 nsp12, the RNA-dependent RNA-polymerase plays a crucial role in virus replication. Monitoring the effect of its emerging mutants on viral replication and response to antiviral drugs is important. Nsp12 of two Egyptian isolates circulating in 2020 and 2021 were sequenced. Both isolates included P323L, one included the A529V. Tracking A529V mutant frequency, it relates to the transience peaked
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In silico study of inhibition activity of boceprevir drug against 2019-nCoV main protease Z. Naturforschung C (IF 2.0) Pub Date : 2023-12-29 Gargi Tiwari, Madan Singh Chauhan, Dipendra Sharma
Boceprevir drug is a ketoamide serine protease inhibitor with a linear peptidomimetic structure that exhibits inhibition activity against 2019-nCoV main protease. This paper reports electronic properties of boceprevir and its molecular docking as well as molecular dynamics simulation analysis with protein receptor. For this, the equilibrium structure of boceprevir has been obtained by DFT at B3LYP
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Comparison of lignocellulosic enzymes and CAZymes between ascomycetes (Trichoderma) and basidiomycetes (Ganoderma) species: a proteomic approach Z. Naturforschung C (IF 2.0) Pub Date : 2023-12-13 Akshay Shankar, Kavish Kumar Jain, Ramesh Chander Kuhad, Krishna Kant Sharma
Wood decomposing ascomycetes and basidiomycetes group of fungi are the most valuable microbes on the earth’s ecosystem that recycles the source of carbon; therefore, they are essential for the biorefinery industries. To understand the robustness of the enzymes and their metabolic pathways in the fungal system, label-free quantification of the total proteins was performed. The fungi showed a comparable
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Design, synthesis, and biological activity studies of carbonic anhydrase inhibitors Z. Naturforschung C (IF 2.0) Pub Date : 2023-11-04 Delal Erzurum, Derya Osmaniye, Begüm Nurpelin Sağlık, Serkan Levent, Yusuf Özkay, Zafer Asım Kaplancıklı
Carbonic anhydrase (CA) enzymes are a common catalytic enzyme in many organisms. Vertebrates and invertebrates have different CA isoforms. Sixteen different isozymes of the α-CA isoform found in vertebrates have been identified so far. The main task of this enzyme is to catalyze the reversible conversion of carbon dioxide into bicarbonate and hydrogen ions in the body. It is widely distributed in many
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Design, synthesis and apoptotic effects of novel benzoxazole compounds Z. Naturforschung C (IF 2.0) Pub Date : 2023-10-31 Betül Kaya, Leyla Yurttaş, Gülşen Akalın-Çiftçi, Mehmet Onur Aksoy
A series of new benzoxazole-hydrazone and benzoxazole-1,3,4-oxadiazole derivatives have been designed, synthesized and evaluated as cytotoxic agents toward human A549 lung cancer cells. Compounds 3d, 3e, 5b, 5c, 5d and 5e were the most potent compounds with IC50 values of <3.9, 10.33, 11.6, 5.00, <3.9 and 4.5 μg/mL, respectively, which are higher than reference drug cisplatin (IC50 = 19.00 μg/mL).
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Terpenoid compounds from the fruits of Solanum virginianum Z. Naturforschung C (IF 2.0) Pub Date : 2023-09-25 Yan Liu, Shuang Liu, Zhen-Peng Xu, Si-Yi Wang, Yi-Kai Jiang, Wei Guan, Juan Pan, Hai-Xue Kuang, Bing-You Yang
Eleven compounds were isolated and identified from ethanolic extracts of Solanum virginianum fruits, including two new compounds (1–2) and nine known compounds (3–11). Their structures were determined to be melongenaterpene C15-O-β-D-glucopyranoside (1), (9Z)-3,7,11,15-tetramethyl -hexadeca-1,6,10-triene-3,5,14,15-tetraol-5-O-β-D-glucopyranoside (2), actini-dioionoside A (3), byzantionoside B (4),
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Dietary flavonoid myricetin 3-O-galactoside suppresses α-melanocyte stimulating hormone-induced melanogenesis in B16F10 melanoma cells by regulating PKA and ERK1/2 activation Z. Naturforschung C (IF 2.0) Pub Date : 2023-09-13 Jung Hwan Oh, Fatih Karadeniz, Youngwan Seo, Chang-Suk Kong
Melanogenesis is the process where skin pigment melanin is produced through tyrosinase activity. Overproduction of melanin causes skin disorders such as freckles, spots, and hyperpigmentation. Myricetin 3-O-galactoside (M3G) is a dietary flavonoid with reported bioactivities. M3G was isolated from Limonium tetragonum and its anti-melanogenic properties were investigated in α-melanocyte stimulating
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A new alkaloid from Portulaca oleracea L. with its anti-inflammatory activity Z. Naturforschung C (IF 2.0) Pub Date : 2023-09-12 Junjie Yao, Lina Wang, Peishan Liu, Mingyang Song, Jiayin Tian, Fan He, Xixiang Ying
A new isoindole alkaloid, 6-hydroxy-2-(4′′′-hydroxy-3′′′-methoxyphenethyl)-4-(4′-hydroxy-3′-methoxyphenyl)-7-methoxy-1H-benzo[f]isoindole-1,3(2H)-dione, named oleraisoindole B was isolated from Portulaca oleracea L., its structure was elucidated using NMR and UHPLC-ESI-Q-TOF/MS spectroscopic methods, and presented anti-inflammatory activity at 5 μM.
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Evaluation of maceration, microwave, ultrasound-assisted extraction methods on free, esterified and bound phenolic profile and antioxidant activity of black rice Z. Naturforschung C (IF 2.0) Pub Date : 2023-09-08 Md. Latifur Rahman, Subhajit Mandal, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Ranabir Sahu
Black rice (Oryza sativa L.) is a rich source of phenolics and anthocyanins. It was aimed to investigate the effect of different extraction methods such as conventional solvent extraction, ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE) on antioxidant activity and phenolic profiling of black rice free, esterified, and bound phenolics fractions. Spectrophotometric methods
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Crystal structure of phloridzin and its distribution changes in flowering and fruiting stage of Malus rockii Z. Naturforschung C (IF 2.0) Pub Date : 2023-08-23 Hui-Rong Bai, Jing Li, Li-Juan Lang, Yi Hao, Bei Jiang, Chao-Jiang Xiao
The exact structure of phloridzin was further confirmed as phloretin 6′-O-glucopyranoside by a single-crystal X-ray diffraction experiment. The distribution changes of phloridzin in flowering, fruitlet, and fruit ripening phases of Malus rockii were quantified by an HPLC with an external standard. The concentrations of phloridzin in leaves, twigs, and bark and xylem of twigs increased at first and
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GABase and glutaminase inhibitory activities of herbal extracts and acylated flavonol monoglycosides isolated from the leaves of Laurus nobilis L. Z. Naturforschung C (IF 2.0) Pub Date : 2023-08-03 Atsumi Shimada, Hiroshi Ueno, Kohei Kawabata, Masanori Inagaki
This study was to compare GABase [a mixture of γ-aminobutyric acid (GABA) aminotransferase and succinic semialdehyde dehydrogenase] and glutaminase inhibitory activities of 20 herbal extracts and investigate the isolation, structural elucidation and those inhibitory activities of three acylated flavonol monoglycosides from the selected extract of Laurus nobilis L. (laurel). On the basis of the NMR
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Identification of tuliposides K–M in tulip bulbs via an enzyme reaction-based screening method using a tuliposide-converting enzyme Z. Naturforschung C (IF 2.0) Pub Date : 2023-07-05 Taiji Nomura, Ayami Omode, Yasuo Kato
Tuliposides (Pos) are major defense-related secondary metabolites in tulip, having 4-hydroxy-2-methylenebutanoyl and/or (3S)-3,4-dihydroxy-2-methylenebutanoyl groups at the C-1 and/or C-6 positions of d-glucose. The acyl group at the C-6 position is converted to antimicrobial lactones (tulipalins) by an endogenous Pos-converting enzyme. Based on this enzyme activity, we examined tulip bulb extracts
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Anti-SARS-CoV-2 in vitro potential of castor oil plant (Ricinus communis) leaf extract: in-silico virtual evidence Z. Naturforschung C (IF 2.0) Pub Date : 2023-07-04 Rawah H. Elkousy, Zeinab N. A. Said, Mohamed A. Ali, Omnia Kutkat, Salwa A. Abu El Wafa
Ricinus communis L. is a medicinal plant that displays valuable pharmacological properties, including antioxidant, antimicrobial, analgesic, antibacterial, antiviral and anti-inflammatory properties. This study targeted to isolate and identify some constituents of R. communis leaves using ultra-performance liquid chromatography coupled with mass spectroscopy (UPLC-MS/MS) and different chromatographic
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Secondary metabolites from the marine-derived fungus Penicillium chrysogenum Y20-2, and their pro-angiogenic activity Z. Naturforschung C (IF 2.0) Pub Date : 2023-06-25 Yue-Zi Qiu, Yong-Qiang Zhu, Hong Lu, Xiao-Bin Li, Ke-Chun Liu, Pei-Hai Li, Li-Zhen Wang, Xuan-Ming Zhang, Hao Chen, Hou-Wen Lin, Shan-Shan Zhang
A systematic chemical study of the secondary metabolites of the marine fungus, Penicillium chrysogenum (No. Y20-2), led to the isolation of 21 compounds, one of which is new (compound 3). The structures of the 21 compounds were determined by conducting extensive analysis of the spectroscopic data. The pro-angiogenic activity of each compound was evaluated using a zebrafish model. The results showed
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SOCSs: important regulators of host cell susceptibility or resistance to viral infection Z. Naturforschung C (IF 2.0) Pub Date : 2023-05-26 Xin Zhang, Hengchuan Xia, Qian Wang, Miao Cui, Cong Zhang, Qiang Wang, Xiaoyong Liu, Keping Chen
Suppressors of cytokine signaling (SOCSs) are implicated in viral infection and host antiviral innate immune response. Recent studies demonstrate that viruses can hijack SOCSs to inhibit Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway, block the production and signaling of interferons (IFNs). At the same time, viruses can hijack SOCS to regulate non-IFN factors to
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Essential oils of the ginger plants Meistera caudata and Conamomum vietnamense: chemical compositions, antimicrobial, and mosquito larvicidal activities Z. Naturforschung C (IF 2.0) Pub Date : 2023-05-11 Le Thi Huong, Ninh The Son, Ly Ngoc Sam, Phan Nhat Minh, Nguyen Dinh Luyen, Nguyen Huy Hung, Do Ngoc Dai
The current study describes the chemical identification, antimicrobial, and mosquito larvicidal activities of essential oils from Meistera caudata and Conamomum vietnamense, growing in Vietnam. Essential oils were extracted from the leaves and rhizomes, and characterized by the GC-FID/MS (gas chromatography-flame ionization detection/mass spectrometry) analysis. Monoterpenes (33.1–89.2 %) were the
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The search for commercial sweet white lupin (Lupinus albus L.) adaptive to Ethiopian growing condition seems not successful: what should be done? Z. Naturforschung C (IF 2.0) Pub Date : 2023-04-28 Likawent Yeheyis, Wondimeneh Mekonnen, Matthew Nelson, David Mcnaughton, Alemu Tarekegn, Zelalem Yadelew, Heather Sanders
The study was conducted to find new adaptive commercial sweet white lupin (Lupinus albus L.) varieties and evaluate the effect of inoculum on herbage and seed yields of white and blue lupin varieties in Ethiopia for two growing seasons in two locations. For the experiment a factorial arrangement (seven variety * two inoculation) in a randomized complete block design with three replication was used
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Berberine may provide redox homeostasis during aging in rats Z. Naturforschung C (IF 2.0) Pub Date : 2023-04-13 Arun Kumar Yadawa, Parisha Srivastava, Akanksha Singh, Rashmi Kesherwani, Sukanya Bhoumik, Raushan Kumar, Jitendra Kumar Arya, Syed Ibrahim Rizvi
Aging is a natural phenomenon, which is characterised by progressive physiological changes at cellular and organ level. During aging, the defence mechanism of an organism declines over the period of time. The aim of this study was to investigate the biological efficacy of berberine in D-galactose induced aging rat models. For the study, rats were divided into four groups: Control received only vehicle
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Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines Z. Naturforschung C (IF 2.0) Pub Date : 2023-04-08 Elek Ferencz, Gabriella Spengler, István Zupkó, Martin Vollár, Zoltán Péter Zomborszki, Norbert Kúsz, Judit Hohmann, Balázs Kovács, Dezső Csupor, Eszter Laczkó-Zöld, Boglárka Csupor-Löffler
Common ragweed (Ambrosia artemisiifolia L.) is an invasive plant in Europe with spreading use in the contemporary folk medicine. The chemical composition of the above-ground parts is extensively studied, however, the metabolites of the roots are less discovered. By multiple chromatographic purification of the root extracts, we isolated thiophene A (1), n-dodecene (2), taraxerol-3-O-acetate (3), α-linoleic
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Essential oil composition, anti-tyrosinase activity, and molecular docking studies of Knema intermedia Warb. (Myristicaceae) Z. Naturforschung C (IF 2.0) Pub Date : 2023-03-24 Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, William N. Setzer
Knema is one of the genera in the Myristicaceae family. The genus includes 60 species in Southeast Asia and is traditionally used for treating skin disorders. Here, for the first time, the essential oil, anti-tyrosinase, and molecular docking studies of Knema intermedia were evaluated. The essential oil was obtained by hydrodistillation and fully characterized by gas chromatography (GC-FID) and gas
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Proximate analysis and fatty acid, mineral and soluble carbohydrate profiles of some brown macroalgae collected from Türkiye coasts Z. Naturforschung C (IF 2.0) Pub Date : 2023-02-23 Aysun Yucetepe, Elif Feyza Aydar, Emine Şükran Okudan, Beraat Özçelik, Gökhan Durmaz
In this study, the fatty acid, carbohydrate, and mineral profiles and proximate composition of Halopteris scoparia, Padina pavonica, Zanardinia typus, Cladostephus spongiosum, Sargassum vulgare, and Sargassum acinarium brown macroalgae collected from Türkiye seas were determined. According to the results, the ash and total carbohydrate contents of all macroalgae ranged from 20.79 to 53.49% in dry weight
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Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Croton oligandrus Pierre ex. Hutch (Euphorbiaceae) Z. Naturforschung C (IF 2.0) Pub Date : 2023-02-21 Vanneck Bedel Tatsinda Tsapi, Yannick Stéphane Fotsing Fongang, Angelbert Fusi Awantu, Jean Jules Kezetas Bankeu, Mehreen Lateef, Jean Rodolphe Chouna, Pépin Nkeng-Efouet-Alango, Muhammad Shaiq Ali, Bruno Ndjakou Lenta
Crotofoligandrin (1), a new endoperoxide crotofolane-type diterpenoid was isolated from the dichloromethane/methanol (1:1) extract of the twigs of Croton oligandrus Pierre Ex Hutch along with thirteen known secondary metabolites including 1-nonacosanol (2), lupenone (3), friedelin (4), β-sitosterol (5), taraxerol (6), (−)-hardwickiic acid (7), apigenin (8), acetyl aleuritolic acid (9), betulinic acid
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Thermodynamic control synthesis of spiro[oxindole-3,3′-pyrrolines] via 1,4-dipolar cycloaddition utilizing imidazo[1,5-a]quinoline Z. Naturforschung C (IF 2.0) Pub Date : 2023-02-17 Areej M. Jaber, Jalal A. Zahra, Mustafa M. El-Abadelah, Salim S. Sabri, Dua’a S. Sabbah
A series of novel 2-(quinolin-2-yl)-spiro[oxindole-3,3′-pyrrolines] were synthesized by one-pot three-component reaction involving dimethyl acetylenedicarboxylate, 1-phenylimidazo[1,5-a]quinoline and N-alkylisatins in chloroform at ∼60 °C for 24 h. Structures of these new spiro derivatives were deduced from HRMS and NMR spectral data. A plausible mechanism for the observed thermodynamic control pathway
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Structure elucidation of an aspidofractinine-type monoterpene indole alkaloid from Melodinus reticulatus Z. Naturforschung C (IF 2.0) Pub Date : 2023-02-16 Adrien Jagora, Sarah Szwarc, Marc Litaudon, Vincent Dumontet, Jean-François Gallard, Mehdi A. Beniddir, Pierre Le Pogam
The structure and complete NMR assignments of aspidoreticulofractine, an aspidofractinine N-oxide, are reported. Its structure was elucidated based on a combination of spectroscopic techniques including 1D and 2D NMR, high-resolution mass spectrometry, and electronic circular dichroism.
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Chemical composition of different plant part from Lactuca serriola L. – focus on volatile compounds and fatty acid profile Z. Naturforschung C (IF 2.0) Pub Date : 2023-02-13 Emil N. Shukurlu, Gulmira Özek, Temel Özek, Sara Vitalini
The family Asteraceae comprises many species that have medicinal importance in terms of their chemical components. Some species of the genus Lactuca have been used in folk medicine for a long time ago. One of them is L. serriola L., a wild plant that is a weed in agriculture. To date, few studies have been published on its chemical profile. In this research, we investigated the volatile compounds and
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Two new natural products from Portulaca oleracea L. and their bioactivities Z. Naturforschung C (IF 2.0) Pub Date : 2023-02-10 Mingyang Song, Zheming Ying, Xixiang Ying, Lianqun Jia, Guanlin Yang
Two new natural products, belonging to alkaloids, identified as ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl acetate (1) and (5-hydroxypyridin-2-yl)methyl acetate (2), were isolated from Portulaca oleracea L. The structures were identified by spectroscopic methods, including 1D, 2D NMR, and UHPLC-ESI-QTOF/MS methods. Meanwhile, the anti-inflammatory
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Limonoids and insecticidal activity on Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) of Trichilia catigua A. Juss. (Meliaceae) Z. Naturforschung C (IF 2.0) Pub Date : 2022-12-27 Cristiane M. Cazal, Andreia P. Matos, Vanessa de Cássia Domingues, Gracielle Oliveira Sabbag Cunha, Paulo Cezar Vieira, Maria Fátima das Graças Fernandes da Silva, João Batista Fernandes
The aim of the study was to evaluate the effects of the seeds, exocarp and aril extracts from Trichilia catigua A. Juss. (Meliaceae) against Spodoptera frugiperda and present the phytochemical study carried out with the aril extract of T. catigua. Limonoids were isolated from the aril of T. catigua through chromatographic techniques and their structures were proposed by spectroscopic analysis and comparison
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Tissue specific changes of phytochemicals, antioxidant, antidiabetic and anti-inflammatory activities of tea [Camellia sinensis (L.)] extracted with different solvents Z. Naturforschung C (IF 2.0) Pub Date : 2022-12-24 Tania Baishya, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Malay Bhattacharya, Ranabir Sahu
Different parts of Camellia sinensis (L.) were extracted with solvents according to polarity, and the extracts’ phytochemical profiling and biological activities were examined. The total phenolic (TPC) and total flavonoid (TFC) contents increased with the increasing polarity of the solvent which met its maximum in polar solvents. The increasing antioxidant, anti-inflammatory and antidiabetic activities
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Anonazepine, a new alkaloid from the leaves of Annona muricata (Annonaceae) Z. Naturforschung C (IF 2.0) Pub Date : 2022-12-22 Ngoc Vinh Huynh, Duc Minh Nguyen Huu, Ngoc Trinh Huynh, Duc Hoa Chau, Cong Dinh Nguyen, Quoc Dung Nguyen Truong, Dinh Tri Mai, Phu Hoang Dang
From the CHCl3-soluble extract of Annona muricata L. (Annonaceae) leaves, one new 3-benzazepine-type alkaloid, anonazepine (1), and four known aporphine-type alkaloids, (+)-laurotetanine (2), (+)-norglaucine (3), (−)-xylopine (4), and lanuginosine (5), were isolated. Except for (−)-xylopine (4), these remaining known alkaloids were first reported in A. muricata. The structures of the isolated alkaloids
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Furoquinoline and bisindole alkaloids from the roots of Teclea nobilis and their in-silico molecular docking analysis Z. Naturforschung C (IF 2.0) Pub Date : 2022-11-11 Tamrat Tesfaye Ayele, Getahun Tadesse Gurmessa, Zelalem Abdissa, Yadessa Melaku, Ankita Garg, Kibrom Gebreheiwot Bedane, Negera Abdissa
Teclea nobilis is a medicinal plant widely used to treat oral pathogens, gonorrhea, fever, analgesics, asthma, joint pains, pneumonia, and intestinal worms in Ethiopia. Anticipated by these claims, column chromatographic separation of the roots extract of T. nobilis led to the isolation of eight alkaloids (1–8). The structures of the isolated compounds were identified based on their NMR (1D and 2D)
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Novel sialidase from non-pathogenic bacterium Oerskovia paurometabola strain O129 Z. Naturforschung C (IF 2.0) Pub Date : 2022-11-09 Rumyana T. Eneva, Stephan A. Engibarov, Yana G. Gocheva, Simona L. Mitova, Penka M. Petrova
Bacterial sialidases are enzymes that are involved in a number of vital processes in microorganisms and in their interaction with the host or the environment. Their wide application for scientific and applied purposes requires the search for highly effective and non-pathogenic producers. Here, we report the first description of sialidase from Oerskovia paurometabola. The extracellular enzyme preparation
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Isolation and purification of 12 flavonoid glycosides from Ginkgo biloba extract using sephadex LH-20 and preparative high-performance liquid chromatography Z. Naturforschung C (IF 2.0) Pub Date : 2022-11-09 Ping Li, Hao Sun, Wei Li, Qi Wu, Shuhong Ye, Jingbo Zhu, Yan Ding
An efficient and rapid preparative method for the separation and purification of flavonoid glycosides from the Ginkgo biloba extract (GBE) was developed by sephadex LH-20 and preparative high-performance liquid chromatography (HPLC). 40 g GBE of 24% flavonoids were loaded onto the sephadex LH-20 column and five fractions (1.15, 2.57, 1.32, 4.45, and 3.31 g) at flavonoid content of 72.3, 54.2, 63.5
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In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera Z. Naturforschung C (IF 2.0) Pub Date : 2022-11-02 Salha M. Aljubiri, Eman Abd Elsalam, Faten K. Abd El Hady, Mohamed O. Radwan, Abdulrahman I. Almansour, Kamel H. Shaker
Acetylcholinesterase, tyrosinase, and α-glucosidase inhibition activities of Euphorbia schimperiana and Euphorbia balsamifera extracts, fractions, and available pure compounds were evaluated for the first time. Acetylcholinesterase assay revealed a significant inhibitory activity of E. balsamifera total extract and n-hexane fraction with 47.7% and 43.3%, respectively, compared to the reference drug
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Sesquiterpenoids from Tithonia diversifolia (Hemsl.) A. Gray induce apoptosis and inhibit the cell cycle progression of acute myeloid leukemia cells Z. Naturforschung C (IF 2.0) Pub Date : 2022-11-02 Trinh Thi Thuy, Nguyen Thi Thuy Linh, Ba Thi Cham, Nguyen Thi Hoang Anh, Tran Duc Quan, Nguyen Thanh Tam, Le Thi Hong Nhung, Do Thi Thao, Nguyen Phi Hung, Vu Dinh Hoang, Sabrina Adorisio, Domenico V. Delfino
Three sesquiterpene lactones (1–3) were isolated from the aerial part of Tithonia diversifolia (Hemsl.) A. Gray grown in the Hoa Binh province in Viet Nam. The structures of these three sesquiterpene lactones were identified as tagitinin A (1), 1β-hydroxytirotundin 3-O-methyl ether (2), and tagitinin C (3) by analyzing spectroscopic data. For the first time, compound 2 was isolated from T. diversifolia
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Chemical constituents from Ficus sur Forssk (Moraceae) Z. Naturforschung C (IF 2.0) Pub Date : 2022-11-02 Eitel Ngoh Misse Mouelle, Mohamed Foundikou Nsangou, Vanini Samiyatou Michiren Mandou, Jean Duplex Wansi, Sergi Herve Akone, Emmanuel Ngeufa Happi
Phytochemical investigation of the aerial roots of Ficus sur, a Cameroonian medicinal plant, resulted in a previously undescribed cerebroside, suroside (1), in addition to its aglycon congener suramide (2). Moreover, six known natural products including alpinumisoflavone (3), wighteone metabolite (4), oleanolic acid (5), β-sitosterol (6), β-sitosterol-3-O-β-D-glucopyranoside (7), and epi-ѱ-taraxastanolone
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8-Amino-7-(aryl/hetaryl)fluoroquinolones. An emerging set of synthetic antibacterial agents Z. Naturforschung C (IF 2.0) Pub Date : 2022-10-21 Ala’a A. Al-Akhras, Jalal A. Zahra, Mustafa M. El-Abadelah, Lubna F. Abu-Niaaj, Monther A. Khanfar
This study reports the synthesis of seven new 8-amino-7-(aryl/hetaryl)fluoroquinolones and their antibacterial activity against 10 bacteria associated with microbial infections and foodborne illnesses. These fluoroquinolones are prepared via the reactions of selected aryl(hetaryl)boronic acids with ethyl-7chloro-6-fluoro-8-nitroquinolone-3-carboxylate, under Suzuki–Miyaura cross-coupling conditions
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Insecticidal activities of the essential oil of Rhynchanthus beesianus rhizomes and its constituents against two species of grain storage insects Z. Naturforschung C (IF 2.0) Pub Date : 2022-09-22 Xiujuan Pan, He Xiao, Xinping Hu, Zhi Long Liu
The aim of this research was to evaluate insecticidal activities of the essential oil of Rhynchanthus beesianus rhizomes against adults of Liposcelis entomophila and Tribolium castaneum. Gas chromatography-mass spectrometry analyses revealed the presence of 44 compounds with β-eudesmol (19.1%), elemol (8.1%), α-terpineol (8.0%), methyl eugenol (6.5%), and caryophyllene (4.8%) being the major constituents
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Chemical composition and anticholinesterase activity of Lepisanthes rubiginosa (Roxb.) Leenh. essential oil Z. Naturforschung C (IF 2.0) Pub Date : 2022-09-16 Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani, Abu-Baker M. Abdel-Aal
Essential oils obtained from medicinal plants show high therapeutic potential against several types of pathologies, including Alzheimer’s disease. The purpose of this work was to study the chemical composition and anticholinesterase inhibitory activity of the essential oil obtained from Lepisanthes rubiginosa leaves collected from Malaysia. Twenty-four components were identified using gas chromatography-flame
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Covid-19 vaccines and neurological complications: a systematic review Z. Naturforschung C (IF 2.0) Pub Date : 2022-09-10 Fakhri Allahyari, Hamideh Molaee, Javad Hosseini Nejad
The COVID-19 mainly causes respiratory disorders with high infection and severe morbidity and mortality. Neurologists have concerns about potential neurological side effects, profits, and timing of COVID-19 vaccines. This study aimed to review systematically research for the COVID-19 vaccine and neurological complications. Data was searched in Scopus, ISI web of knowledge, Medline, PubMed, Wiley, Embase
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Santalum Genus: phytochemical constituents, biological activities and health promoting-effects Z. Naturforschung C (IF 2.0) Pub Date : 2022-09-07 Javad Sharifi-Rad, Cristina Quispe, Aknur Turgumbayeva, Zehra Mertdinç, Sena Tütüncü, Elif Feyza Aydar, Beraat Özçelik, Stępień-Warda Anna, Staniak Mariola, Anna Koziróg, Anna Otlewska, Hubert Antolak, Surjit Sen, Krishnendu Acharya, Natallia Lapava, Simin Emamzadeh-Yazdi, Miquel Martorell, Manoj Kumar, Elena Maria Varoni, Marcello Iriti, Daniela Calina
Santalum genus belongs to the family of Santalaceae, widespread in India, Australia, Hawaii, Sri Lanka, and Indonesia, and valued as traditional medicine, rituals and modern bioactivities. Sandalwood is reported to possess a plethora of bioactive compounds such as essential oil and its components (α-santalol and β-santalol), phenolic compounds and fatty acids. These bioactives play important role in
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Chemical composition and bioactivities of Magnolia candollii H.Keng essential oil Z. Naturforschung C (IF 2.0) Pub Date : 2022-08-26 Ahmad Azrul Hakim Yahaya, Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani, Shamsul Khamis, Nurul Syafiqah Rezali, Mohd Afiq Aizat Juhari
Several Magnolia species have exhibited potent biological activities such as anti-inflammatory, anti-angiogenesis, anticonvulsant, anti-obesity, and antiviral activities. However, the Magnolia candollii from Malaysia has not been investigated yet. Hence, this study aims to investigate the chemical composition and bioactivities of the essential oil of Magnolia candollii H.Keng from Malaysia. The hydrodistillation
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Design, synthesis, and molecular docking study of novel cinnoline derivatives as potential inhibitors of tubulin polymerization Z. Naturforschung C (IF 2.0) Pub Date : 2022-08-22 Eman Mohammad Mahmoud, Musa Shongwe, Ebrahim Saeedian Moghadam, Parsa Moghimi-Rad, Raphael Stoll, Raid Abdel-Jalil
The preparation of a novel 4-methylbenzo[h] cinnolines entity via a three-step synthetic protocol is described. Cyclization of the naphthylamidrazones, in the presence of polyphosphoric acid (PPA), furnishes the respective target benzo[h]cinnolines directly. This one-pot synthesis involves intramolecular Friedel–Crafts acylation followed by instant elimination under heating conditions. It is noteworthy
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Do Colletotrichum gloeosporioides and Rhizopus stolonifer induce alkaloidal and antifungal responses in Annona muricata seedlings? Z. Naturforschung C (IF 2.0) Pub Date : 2022-08-09 Christian Anabi Riley-Saldaña, Ivan de-la-Cruz-Chacón, María del Rocío Cruz-Ortega, Marisol Castro-Moreno, Alma Rosa González-Esquinca
The benzylisoquinoline alkaloids of Annona muricata have been isolated, but their physiological or ecological role is unknown. The objective was to explore whether these secondary metabolites are involved in defense against phytopathogenic fungi. To do this, the alkaloidal response of 6-leaf seedlings of A. muricata was analyzed, previously inoculated with Colletotrichum gloeosporioides and Rhizopus
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Design, synthesis and antimicrobial assessments of aminoacetylenic-piperazine nitroimidazole hybrid compounds Z. Naturforschung C (IF 2.0) Pub Date : 2022-08-09 Anas J. Rasras, Raed A. Al-Qawasmeh, Mohamed El-Naggar, Ihsan Shehadi, Mahmoud M. Elaasser, Yaseen A. Al-Soud
A new series of aminoacetylenic nitroimidazole piperazine hybrid compounds were prepared via three-component reaction. Mannich-type reaction was utilized to couple the nitroimidazole containing propargylic moiety with secondary amines and formaldehyde in the presence of Cu (I) catalyst. The newly synthesized molecules 10a–10w, were characterized an ambiguously through NMR and mass spectrometry. The
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Thiophene ring-opening reactions VI. Attempted cyclization towards [fused]-tricyclic system involving a thiolate anion and suitably located electrophilic carbon Z. Naturforschung C (IF 2.0) Pub Date : 2022-08-08 Ahmad H. Abdullah, Jalal A. Zahra, Salim S. Sabri, Firas F. Awwadi, Ahmad Q. Hussein, Mustafa M. El-Abadelah
Model α-chloro-β-nitrothieno[2,3-c]pyridazines incorporating N1-(aryl) entity appended with ortho-methoxycarbonyl or trifluoromethyl group were prepared via intramolecular cyclization of their respective N-arylhydrazone precursors. Interaction of these substrates with N′-(p-fluorophenyl)benzothiohydrazide, in the presence of NEt3, furnished the respective 1,3,4-thiadiazoline–pyridazine thiolate hybrids
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Synthesis of new derivatives containing pyridine, investigation of MAO inhibitory activities and molecular docking studies Z. Naturforschung C (IF 2.0) Pub Date : 2022-07-20 Derya Osmaniye, Begüm Nurpelin Sağlık, Serkan Levent, Yusuf Özkay, Zafer Asım Kaplancıklı, Gülhan Turan
In this study, novel pyridine-containing thiazolyl hydrazone derivatives were synthesized. Structure determinations of the compounds were performed using 1H NMR, 13C NMR and HRMS techniques. The biological activities of the compounds were evaluated against MAO enzymes by in vitro fluorometric method. As a result of activity studies, compound 3a showed selective inhibitory activity against MAO-B enzyme
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Sakuranetin and its therapeutic potentials – a comprehensive review Z. Naturforschung C (IF 2.0) Pub Date : 2022-07-13 Md. Junaid, Bristy Basak, Yeasmin Akter, Syeda Samira Afrose, Afsana Nahrin, Rashiduzzaman Emran, Md. Shahinozzaman, Shinkichi Tawata
Sakuranetin (SKN), a naturally derived 7-O-methylated flavonoid, was first identified in the bark of the cherry tree (Prunus spp.) as an aglycone of sakuranin and then purified from the bark of Prunus puddum. It was later reported in many other plants including Artemisia campestris, Boesenbergia pandurata, Baccharis spp., Betula spp., Juglans spp., and Rhus spp. In plants, it functions as a phytoalexin
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Chemical constituents of Desmodium triflorum and their antifungal activity against various phytopathogenic fungi Z. Naturforschung C (IF 2.0) Pub Date : 2022-06-29 Hieu Nguyen-Ngoc, Trang Nguyen-Thi-Thu, Kieu-Anh Vo-Thi, Tung Nguyen-Huu, Lam Tran-Dai, Hoang Dinh Vu, Duc Trong Nghiem, Quang Le Dang
In the course of finding new antifungal natural compounds against plant pathogens, the methanol extract of Desmodium triflorum was investigated phytochemically. From n-butanol-soluble fraction, seven compounds (1–7) were isolated and structurally elucidated. Of which, six compounds belong to flavone 6- or 8-C-glycoside class (1–6). Three major compounds (1–3) exhibited moderate in vitro antifungal
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Exploring phytochemical constituents of Achillea arabica Kotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats Z. Naturforschung C (IF 2.0) Pub Date : 2022-06-29 Hanife Ceren Hanalp, Abdulahad Dogan, Tuba Kusman Saygi, Fatih Donmez, Abdulhamit Battal
The aim of this study was to reveal the antidiabetic and antioxidant effects of ethanolic lyophilized extract of Achillea arabica flower extract against streptozotosine (STZ)-induced in diabetic rats and to determine its phytochemical content by liquid chromatography with tandem mass spectrometry (LC-MS/MS). After toxicity test, 35 female rats were divided into five groups. Control, diabetes mellitus
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Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom Z. Naturforschung C (IF 2.0) Pub Date : 2022-06-28 Jenifer Frouche de Souza, Marcos Vinicius da Silva Santana, Ana Cláudia Rodrigues da Silva, Marcio Roberto Henriques Donza, Vitor Francisco Ferreira, Sabrina Baptista Ferreira, Eladio Flores Sanchez, Helena Carla Castro, André Lopes Fuly
Snakebite envenoming is a health concern and has been a neglected tropical disease since 2017, according to the World Health Organization. In this study, we evaluated the ability of ten 1,2,3-triazole derivatives AM001 to AM010 to inhibit pertinent in vitro (coagulant, hemolytic, and proteolytic) and in vivo (hemorrhagic, edematogenic, and lethal) activities of Bothrops jararaca venom. The derivatives
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Methylglyoxal and high glucose inhibit VEGFR2 phosphorylation at specific tyrosine residues Z. Naturforschung C (IF 2.0) Pub Date : 2022-06-28 Fabian Betting, Günther Schlunck, Hansjürgen T. Agostini, Gottfried Martin
Diabetes is characterized by hyperglycemia and a significant risk of vascular complications. Vascular endothelial growth factor (VEGF) and its main receptor VEGFR2 (KDR), which is highly expressed in vascular endothelial cells, are essential mediators of vascular maintenance and angiogenesis. During glycolysis after high calorie food intake, methylglyoxal (MGO) is formed and MGO blood levels are elevated
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Antidepressant alkaloids from the rhizomes of Corydalis decumbens Z. Naturforschung C (IF 2.0) Pub Date : 2022-06-24 Qin-Ge Ma, Ye Tang, Mao-Hua He, Rong-Rui Wei
Two new alkaloids (1 and 2), named 1,7-dimethoxy-2′-prenyl-1′,9-dihydropyrrolo-carbazole (1) and 1,7-dimethoxy-4′,5′-dimethylcyclopenta-carbazole-1′,3′-dione (2), along with thirteen known alkaloids (3–15) were isolated by means of silica gel, sephadex LH-20, and semi-preparative HPLC from the CHCl3 extraction of Corydalis decumbens for the first time. Their structures were determined by NMR, MS, IR
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Comparative study of phenolic profile, antioxidant and antimicrobial activities of aqueous extract of white and green tea Z. Naturforschung C (IF 2.0) Pub Date : 2022-05-23 Gamal A. Gabr, Hazem M.M. Hassan, Vidya D. Seshadri, Nahla M.M. Hassan
The sole difference between white tea (WT) and green tea (GT) is the former that made only from the buds and young leaves of the Camelia sinensis plant, whilst the latter is made from matured tea leaves. The phytochemical profiles, phenolic compounds, antioxidant, and antimicrobial activity of two varieties of Camellia sinensis teas, white and green, were compared in this study. Total antioxidant capacity
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Antibacterial, antioxidant, and cytotoxic activities of Syzygium aromaticum (L.) Merr. & Perry essential oil with identification of its chemical constituents Z. Naturforschung C (IF 2.0) Pub Date : 2022-05-23 Wael A. Al-Zereini, Ibrahim N. Al-Trawneh, Mahmoud A. Al-Qudah, Heba M. TumAllah, Zead H. Abudayeh, Tahani Hijazin
Aromatic plants embrace volatile compounds with efficiency in treating different diseases. In Jordan, Syzygium aromaticum flower buds (clove) are extensively used as folk medicine without awareness of its bio-safe dosage. Herein, clove buds were hydrodistilled using the Clevenger apparatus, and the resulting essential oil (CEO) was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). The antibacterial