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Acute and subacute (28 days) oral toxicity studies of tucum almond oil (Bactris Setosa Mart.) in mice Drug Chem. Toxicol. (IF 2.405) Pub Date : 2021-01-13 Luane Aparecida do Amaral; Andressa Carolina Farias Pereira Subtil Cavalcante; Tainá da Silva Fleming de Almeida; Mirelly Marques Romeiro Santos; Luciane Candeloro Portugal; Bárbara Suzuki dos Santos; Felipe Francisco Bittencourt Junior; Thiago Troquez; Carlos Eduardo Domingues Nazário; Leandro Fontoura Cavalheiro; Bruna Paola Murino Rafacho; Antonio Carlos Duenhas Monreal; Rodrigo Juliano Oliveira;
Abstract Oils extracted from almonds are often used with particular interest due to their prospective health effects and benefits. Tucum is a Pantanal fruit widely consumed by local population and no in vivo toxicity studies regarding its safety are available in the literature to date. This study investigated the acute and subacute toxicity of tucum almond oil (TAO) in mice by evaluating its safety
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Factors associated with time to successful weaning in mechanically ventilated organophosphate poisoned patients Drug Chem. Toxicol. (IF 2.405) Pub Date : 2021-01-12 Walaa G. Abdel hamid; Waleed Mansour; Ola E. Nafea
Abstract We designed this study to identify the factors associated with time to successful weaning in mechanically ventilated organophosphate (OP)-poisoned patients as the primary outcomes while duration of mechanical ventilation (MV) support, intensive care unit (ICU), and hospital length of stay (LOS) and in-hospital mortality as the secondary outcomes. We conducted a retrospective study of mechanically
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Melatonin modulates copper-induced anxiety-like, depression-like and memory impairments by acting on hippocampal oxidative stress in rat Drug Chem. Toxicol. (IF 2.405) Pub Date : 2021-01-07 Mouloud Lamtai; Oussama Zghari; Sofia Azirar; Sihame Ouakki; Abdelhalem Mesfioui; Aboubaker EL Hessni; Inssaf Berkiks; Ilias Marmouzi; Ali Ouichou
Abstract Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone that protects neurons from OS and has a modulatory effect on several behavioral processes. The present experiment was aimed to examine the effect of Mel treatment on Cu-induced anxiety-like, depression-like behaviors
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Management site and level of health care for cannabis- and synthetic cannabinoid-related poison control center cases involving older adults, 2016–2019 Drug Chem. Toxicol. (IF 2.405) Pub Date : 2021-01-07 Namkee G. Choi; Diana M. DiNitto; C. Nathan Marti; S. David Baker
Abstract Increasing numbers of older adults use cannabis and cannabis-derived products that can have adverse effects. This study examined management site and level of healthcare services for older adult poison control center cases involving cannabis products. Using the American Association of Poison Control Centers’ (PCC) National Poison Data System, 2016–2019, we extracted the 3109 cases aged 50+
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Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3/miRNA-21 axis Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-21 Iman O. Sherif; Nora H. Al-Shaalan
Abstract The usage of the chemotherapeutic agent methotrexate (MTX) was associated with hepatotoxicity that minimized its clinical use. The Ginkgo biloba extract (GBE) was used before to alleviate the MTX-induced liver injury through its antioxidant activity. This work was carried out to elucidate other molecular hepatoprotective mechanisms of GBE via examining the IL-6/STAT3 pathway in addition to
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Toxicological assessment of a bioactive extract from Triplaris gardneriana Wedd. seeds using alternative models Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-17 Thiago Silva de Almeida; José Joaquim Lopes Neto; Luiz Carlos Pereira Almeida Filho; Daniel Maciel Marques; Rita de Cássia Gonçalves de Lima; Ricardo Gomes dos Santos Nunes; Jailson Renato de Lima Silva; Jean Paul Kamdem; Lécio Leone de Almeida; Juliana Alves da Costa Ribeiro Souza; Davi Felipe Farias; Ana Fontenele Urano Carvalho
Abstract The Triplaris gardneriana Wedd. seeds extract has great therapeutic potential due to numerous biological activities such as antioxidant, antibacterial and anti-inflammatory, which are associated with phenolic content. Although this herbal preparation has shown many benefits, recently their toxicity profile has begun to be explored. In this present study, the toxic effects of T. gardneriana
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The effect of sulfamethoxazole on oxidative stress indices in zebrafish (Danio rerio) Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-06 Nina Tokanová; Radka Dobšíková; Veronika Doubková; Jana Blahová; Zdeňka Svobodová; Petr Maršálek
Abstract The aim of this study was to assess the impact of sulfamethoxazole (SMX) on oxidative stress indices in zebrafish (Danio rerio). The test was completed after 14 days. The tested concentrations were 50, 100 and 500 µg/L of SMX. Glutathione peroxidase, glutathione reductase, glutathione S-transferase and lipid peroxidation were investigated to determine the effects of SMX on oxidative stress
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Borassus flabellifer haustorium extract prevents pro-oxidant mediated cell death and LPS-induced inflammation Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-13 Dhilna Malayil; Nivedya Cheerakuzhi House; Drisya Puthenparambil; Joice Tom Job; Arunaksharan Narayanankutty
Abstract Borassus flabellifer L., belonging to the Arecaceae family, is less explored for its nutritional and biological properties. The plant parts such as the tender kernel, tender water, Borassus flabellifer sap, and haustorium are consumed by various communities in India. The present study first time analyzed the cytoprotective and anti-inflammatory properties of Borassus flabellifer haustorium
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Nano-titanium nitride causes developmental toxicity in zebrafish through oxidative stress Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-09 Jiazhen Wang; Kechun Liu; Cailian Mo; Minchenko H. Oleksandr; Yun Zhang; Jung-Ren Chen; Chung-Der Hsiao; Qing Zhu; Qiuxia He
Abstract Nano-titanium nitride (Nano-TiN) has strong resistance to wear and corrosion, good biocompatibility, and an attractive metallic luster. Nano-TiN is widely used in medical devices, such as orthopedic implants, syringe needles, coronary stents, and long-term dental implants, and also in imitation gold jewelry. Despite its widespread use, there are few reports describing safety evaluations of
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A study of the genetic and prenatal developmental toxicity potential of lithothamnion sp Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-09 Zhang Ying; Tian Ruotao; Wu Haili; Li Shuqin; Bian Linxiu; Li Xuemin; Li Qing
Abstract Due to its calcium-rich and diverse multimineral profile, Aquamin (derived from the red seaweed Lithothamnion sp.) is used globally as a dietary food supplement. Published reports on the genetic and prenatal developmental toxicity of Lithothamnion sp. do not exist. In accordance with the standardized protocols set by the Ministry of Health of the People’s Republic of China (GB-15193), the
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Cytoprotective effects of creosote bush (Larrea tridentata) and Southern live oak (Quercus virginiana) extracts against toxicity induced by venom of the black-tailed rattlesnake (Crotalus ornatus) Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-09 Luis Fernando Plenge-Tellechea; Sergio Acosta-Lara; Joaquín Rodrigo-García; Emilio Álvarez-Parrilla; David Meléndez-Martínez; Ana Gatica-Colima; Jorge A. Sierra-Fonseca
Abstract The venom of Crotalus ornatus (vCo) poses a threat to human health, as it contains a mixture of toxins that can cause cytotoxic, necrotic, and hemolytic effects. The present study assessed methanolic and acetone extracts from leaves and flowers of Larrea tridentata, as well as the bark of Quercus virginiana as potential suppressors of the toxic effects of vCo in vitro. The content of total
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Quercetin alleviates styrene oxide-induced cytotoxicity in cortical neurons in vitro via modulation of oxidative stress and apoptosis Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-09 Sabrine Moujahed; Asier Ruiz; Dorsaf Hallegue; Mohsen Sakly
Abstract Styrene 7,8-oxide (SO) is the principal metabolite of styrene, an industrial neurotoxic compound which causes various neurodegenerative disorders. The present study aimed to explore the mechanisms of SO cytotoxicity (0.5 − 4 mM) in primary cortical neurons and to evaluate the neuroprotective potential of quercetin (QUER). Our results showed that exposure to SO decreased viability of cortical
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Modulatory activities of polyphenols on crude acetylene-induced cardiac and hepatic dysfunctions in a rat model Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-08 Olayinka O. Aladesanmi; Afolabi C. Akinmoladun; Sunday S. Josiah; Mary T. Olaleye; Afolabi A. Akindahunsi
Abstract Exposure to crude acetylene can occur in occupational settings. This study assessed the modulatory activities of selected polyphenols on the hematotoxic, cardiotoxic, and hepatotoxic effects of crude acetylene. Wistar rats were exposed to 58 000 ppm crude acetylene for 10 min at 12 h intervals for 30 days. Some exposed groups were treated with 50 mg/kg rutin, quercetin, gallic acid, or tannic
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Investigation of protective effect of ellagic acid in phthalates-induced reproductive damage Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-08 Neşe Başak Türkmen; İdris Ayhan; Aslı Taşlıdere; Muhterem Aydın; Osman Çiftçi
Abstract Phthalates that people are exposed to every day are toxic carcinogenic chemicals with proven harmful effects on growth and reproduction. Ellagic acid (EA) is a polyphenol derivative known for its antioxidant properties. We hypothesized that the possible reproductive damage mechanism of phthalates is oxidative attack and ellagic acid could have a protective effect against radical forms in the
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Investigation into the protective effects of Hypericum Triquetrifolium Turra seed against cyclophosphamide-induced testicular injury in Sprague Dawley rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-06 Senanur Can; Songül Çetik Yıldız; Cumali Keskin; Varol Şahintürk; Mustafa Cengiz; Sıla Appak Başköy; Adnan Ayhanci; Gülsema Akıncı
Abstract For centuries, Turkey has been a significant location here around 80 species of Hypericum with differing names widely occur, which is also known as Turkish folk medicine in treating some bacterial diseases as well as stomach and intestine inflammation. Recent studies have reported this herb family to contain numbers of bioactive compound contents. The study aims to investigate the protective
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Kigelia Africana (Lam.) Benth leaf extract inhibits rat brain and liver mitochondrial membrane permeability transition pore opening Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-06 John Adeolu Falode; Afolabi Charles Akinmoladun; Mary Tolulope Olaleye; Afolabi Akintunde Akindahunsi
Abstract The effect of Kigelia africana on mitochondrial membrane permeability transition has not been explored. In this study, the effect of a solvent fraction of Kigelia africana leaf extract on mitochondrial membrane permeability transition of rat brain and liver was evaluated. A methanol extract of K. africana leaves was fractionated into different solvents by vacuum liquid chromatography and following
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D-ribose-L-cysteine modulates lead acetate-induced hematobiochemical alterations, hormonal imbalance, and ovarian toxicity in adult female Wistar rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-12-06 Babatunde Ogunlade; Stella C. Gbotolorun; Abosede A. Ogunlade
Abstract Lead is a common environmental toxicant associated greatly with hematological and hormonal imbalance, biochemical alterations, and reproductive abnormalities. This study was conducted to evaluate the effects of D-ribose-L-cysteine (DRLC) on hematobiochemical and reproductive toxicity associated with lead acetate exposure in adult female Wistar rats. Thirty-two adult female Wistar rats (165 ± 20 g)
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Determination of preclinical safety of oil obtained from Pachira aquatica Aublet (Malvaceae) seeds: histopathological, biochemical, hematological, and genetic toxicity studies in rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-30 Jhony Moreira Marcelino; Gustavo Roberto Villas Boas; Mila Cunha; Ramão Deus Júnior; Luis Henrique Castro; Flávio Henrique Araújo; Giseli Karenina Traesel; Ariany Carvalho dos Santos; Roosevelt Isaias Souza; Marina Paes; Priscila Gubert; Zaira da Rosa Guterres; Fernando Freitas de Lima; Tania Silva; Rogério César Silva; Cláudia Andréa Lima Cardoso; Eliana Janet Argandoña; Luis Fernando Macorini; Silvia
Abstract Pachira aquatica is a species used for medicinal and food purposes and has numerous phytochemicals that may have systemic toxic effects and damage to genetic material. This study aimed to evaluate acute and short-term oral toxicity, as well as genotoxic and clastogenic effects of oil extracted from P. aquatica (PASO) seeds in rats and Drosophila melanogaster. The results obtained with biochemical
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Short-term toxicity study of 1-aminobenzotraizole, a CYP inhibitor, in Wistar rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-29 Santosh Kumar Pandey; Harish Nakka; Sudhakar R. Ambhore; Shalini Londhe; Vinod Kumar Goyal; Ramakrishna Nirogi
Abstract 1-Aminobenzotriazole (ABT) is a pan-specific, mechanism-based inhibitor of CYP P450 enzymes, often used as co-treatment to investigate the metabolism-dependent toxicity of drugs or chemicals. To assess the confounding effects of ABT in such kind of mechanistic studies, a repeated dose toxicity study with ABT following 7 days oral administration at 0, 25, 50 and 100 mg/kg/day was performed
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Ellagic acid alleviates clozapine‑induced oxidative stress and mitochondrial dysfunction in cardiomyocytes Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-22 Roya Ahangari; Saleh Khezri; Asal Jahedsani; Saba Bakhshii; Ahmad Salimi
Abstract Clozapine (CLZ) as an antipsychotic agent is very effective in treating of psychosis disorders and resistant schizophrenia, but the risk of severe cardiac toxicity effects restricts its clinical use. There are several interrelated hypotheses to explain clozapine-induced cardiotoxicity which all of them may be related to oxidative stress. Therefore, the current study investigated the harmful
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Effects of prolonged subchronic benzo(α)pyrene exposure on rat liver morphology and CYP1A expression during treatment with menadione, quercetin, or tocopherol Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-19 M. L. Perepechaeva; N. V. Gubanova; A. Y. Grishanova
Abstract Arylamines and polycyclic aromatic hydrocarbons (PAHs) are hazardous anthropogenic pollutants in the environment. The toxicity of PAHs, which include benzo(α)pyrene (BP), is mediated by the activation of Р450 cytochromes of the 1А subfamily (CYP1A1 and CYP1A2). Previously, we have demonstrated that tocopherol, quercetin, and menadione inhibit the expression and activity of CYP1A in the liver
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Effect of carnosic acid on acrylamide induced neurotoxicity: in vivo and in vitro experiments Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-19 Mahboobeh Ghasemzadeh Rahbardar; Batool Hemadeh; Bibi Marjan Razavi; Farhad Eisvand; Hossein Hosseinzadeh
Abstract Acrylamide (ACR), one of the most toxic chemical agents in humans and animals has several uses in different industries. Carnosic acid is an important biological antioxidant extracted from rosemary. In this study, the protective effect of carnosic acid on ACR-induced neurotoxicity in rat and PC12 cells has been investigated. Male Wistar rats were randomly divided into eight groups including
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Subacute toxicity study of the ethanolic extract of Mesua ferrea (L.) flowers in rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-18 Pallavi Shirsat; Ziyaurrahman A. R.; Rama Kashikar; Manjushree Athavale; Tejas Athavale; Pritam Taware; Tina Saldanha; Swati Kolhe; Sachin Tembhurne
Abstract Mesua ferrea Linn. is used traditionally in India and South East Asian countries as an antiseptic, antidote and a brain tonic. Recent pharmacological studies on the plant have highlighted M. ferrea to be a rich source of secondary metabolites, with proven therapeutic applications. Since the toxicity of a plant following repeated exposure is of higher clinical significance, the present investigation
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The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-16 Abdolhamid Esmaeeli; Zahra Keshavarz; Firoozeh Dehdar; Majid Assadi; Mohammad Seyedabadi
Abstract The β-adrenoceptor blockers may have anti-oxidant properties or induce β-arrestin recruitment beyond classical desensitization of receptor/G protein coupling, offering potential therapeutic benefits. Here, we investigated the effects of carvedilol, metoprolol and propranolol in an animal model of cisplatin-induced nephrotoxicity. Rats received the β-blockers (3 or 12 mg/kg/day) with or without
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MicroRNA as an early diagnostic biomarker for contrast-induced acute kidney injury Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-16 Xiaoqin Liu; Yue Li; Xiuli Zhu; Chunyang Jiang
Abstract Contrast-induced acute kidney injury (CI-AKI) is a common clinical complication and an important cause of increased mortality, prolonged hospitalization, and increased medical costs. For taking effective interventions in CI-AKI, early diagnosis and active prevention are of key importance. Currently, early CI-AKI detection depends on serum creatinine (Scr) levels, which lags behind the actual
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Effects of acrylamide on protein degradation pathways in human liver-derived cells and the efficacy of N-acetylcysteine and curcumin Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-16 Abdullah Yahya Salih Al-Hajm; Eray Ozgun
Abstract Acrylamide is a harmful chemical, and its metabolism occurs mainly in the liver. Acrylamide can form adducts on proteins. Protein homeostasis is vital for metabolic and secretory functions of the liver. No study has investigated the effect of acrylamide on the ubiquitin-proteasome system (UPS). Also, the effect of acrylamide on autophagy and its regulation is not fully known. We aimed to investigate
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In vitro glucuronidation of bisphenol A in liver and intestinal microsomes: interspecies differences in humans and laboratory animals Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-13 Nobumitsu Hanioka; Takashi Isobe; Toshiko Tanaka-Kagawa; Hideto Jinno; Susumu Ohkawara
Abstract Bisphenol A (BPA) is an endocrine-disrupting chemical, and is predominantly metabolized into glucuronide in mammals. The present study was conducted in order to examine the hepatic and intestinal glucuronidation of BPA in humans and laboratory animals such as monkeys, dogs, rats, and mice in an in vitro system using microsomal fractions. K m, V max, and CL int values in human liver microsomes
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Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-13 İlknur Yurtsever; Ünsal Veli Üstündağ; İsmail Ünal; Perihan Seda Ateş; Ebru Emekli-Alturfan
Abstract Among the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and neuroinflammation. Calcium is very important for neuronal and glial cells, neurodegenerative disease mechanisms are closely related to disturbed calcium homeostasis. Recent studies
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Neurotoxicity of poly(propylene imine) glycodendrimers Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-13 Ida Franiak-Pietryga; Barbara Ziemba; Hanna Sikorska; Magdalena Jander; Dietmar Appelhans; Maria Bryszewska; Maciej Borowiec
Abstract Published results of studies on poly(propylene imine) (PPI) dendrimers indicate their potential use in the treatment of brain cancer or neurodegenerative diseases due to their ability to cross the blood–brain barrier. However, depending on dose, neurotoxicity may occur. Here, we discuss the impact of maltotriose modified PPI dendrimers on rat’s nervous system. Wistar rats were treated intravenously
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The outbreak of methanol intoxication during COVID-19 pandemic: prevalence of brain lesions and its predisposing factors Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-10 Leila Simani; Mahtab Ramezani; Mehrdad Roozbeh; Shahin Shadnia; Hossein Pakdaman
Abstract During the COVID-19 pandemic, methanol-containing beverages’ consumption has risen because people mistakenly believed that alcohol might protect them against the virus. This study aimed to evaluate the prevalence and predisposing factors of brain lesions in patients with methanol toxicity and its outcome. A total of 516 patients with confirmed methanol poisoning were enrolled in this retrospective
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The effect of long term nicotine exposure on endothelial function in rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-10 Soycan Mizrak; Sibel Göksel Ülker; Gulinnaz Ercan; Birol Sönmez
Abstract Nicotine is one of the main chemicals in the cigarettes responsible for addiction formation. Many researches investigating the effects of nicotine on coronary heart disease and atherosclerosis have been published. The robustness of endothelial cells is very important in the development of atherosclerosis. The aim of this study is to evaluate the effect of nicotine exposure on the indicators
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Cytogenetic effects of antidiabetic drug metformin Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-08 Deniz Yuzbasioglu; Jalank H. Mahmoud; Sevcan Mamur; Fatma Unal
Abstract Metformin (MET) is the first-choice antidiabetic drug for type 2 diabetes mellitus treatment. In this study, the genotoxic potential of MET was evaluated by using chromosome aberrations (CAs), sister chromatid exchanges (SCEs), and micronucleus (MN) assays in human peripheral lymphocytes as well as comet assay in isolated lymphocytes. Human lymphocytes were treated with different concentrations
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The effect of melatonin on testis histological changes and spermatogenesis indexes in mice following treatment with dexamethasone Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-08 Malek Soleimani Mehranjani; Mina Azizi; Firouzeh Sadeghzadeh
Abstract Dexamethasone is a common medicine that is capable of causing malformation in the male reproductive system. The aim of this study was to investigate the effect of melatonin on testis histological changes and Spermatogenesis indexes in adult mice following treatment with dexamethasone. Adult male NMRI mice were divided randomly into four groups: control, dexamethasone (i.p injections, 7 mg/kg/day)
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Genotoxic effects of drospirenone and ethinylestradiol in human breast cells (in vitro) and bone marrow cells of female mice (in vivo) Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-04 Arshad H. Mir; Vinod K. Dumka; Faheem Sultan; Milindmitra K. Lonare
Abstract Estrogen and progesterone congeners as found in various oral contraceptive formulations have been implicated as the cause of cancer in sex and tissue-specific targets. The mechanism of carcinogenesis by sex steroids is still debatable. In this study, we evaluated the genotoxicity induced by two components of one of the commonly used oral contraceptive formulation; drospirenone and ethinylestradiol
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Pterocarpus mildbraedii leaf extract ebbs propanil-induced oxidative and apoptotic damage in the liver of rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-04 Chiagoziem A. Otuechere; Ebenezer O. Farombi
Abstract Phytochemicals derived from plant sources are well recognized as sources of pharmacologically potent drugs in the treatment of several oxidative stress-related ailments. Dichloromethane/methanol (1:1) leaf extract of Pterocarpus mildbraedii was evaluated for its possible protection against oxidative stress and apoptosis in the liver of male Wistar rats exposed to propanil (PRP). In the experimental
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The protective effect of herniarin on genotoxicity and apoptosis induced by cisplatin in bone marrow cells of rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-11-03 Maryam Salehcheh; Omran Safari; Mohammad Javad Khodayar; Hoda Mojiri-Forushani; Mohsen Cheki
Abstract Herniarin is a member of simple coumarins, which are a group of common secondary metabolites in plants. The aim of the present study was to investigate the effects of herniarin on genotoxicity and apoptosis induced by cisplatin in rat bone marrow cells. The experimental rats were treated with four different doses of herniarin (50, 100, 200, and 400 mg/kg.) for seven consecutive days. The cisplatin
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Cumulative effects of manganese nanoparticle and radiofrequency radiation in male Wistar rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-28 Sonali Pardhiya; Usha Singh Gaharwar; Rohit Gautam; Eepsita Priyadarshini; Jay Prakash Nirala; Paulraj Rajamani
Abstract Radiofrequency radiation (RFR) is a type of non-ionizing electromagnetic radiation that includes radiowaves and microwaves with a frequency range between 3 KHz and 300 GHz. Mobile phones operate with RFR and are used tremendously resulting in increased and continuous exposure of humans to these radiations. On the other hand, nanoparticles are also being used extensively in various fields.
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Ixazomib-associated cardiovascular adverse events in multiple myeloma: a systematic review and meta-analysis Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-27 Yiwen Ling; Rui Li; Jiankai Zhong; Ying Zhao; Zhuowen Chen
Abstract Prolonged survival and expanded treatment options in myeloma patients have led to adverse events associated with treatment getting increased attention. This systematic review and meta-analysis aimed to determine the incidence of ixazomib–associated cardiovascular adverse events (CVAEs) and to compare the rates of ixazomib–associated CVAEs and related therapies. CVAEs were defined as heart
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Enniatin B induces dosage-related apoptosis or necrosis in mouse blastocysts leading to deleterious effects on embryo development Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-27 Chien-Hsun Huang; Fu-Ting Wang; Wen-Hsiung Chan
Abstract The current study has focused on the effects of enniatin B (ENN B, a major mycotoxin produced by Fusarium fungi) on early embryonic development. In in vitro analysis, mouse blastocysts were incubated in medium with ENN B (0–40 μM) or 0.5% DMSO (control group) for 24 hours. In an animal study, blastocysts were collected from mice which were intravenously injected with ENN B (1, 3, 5, and 7mg/kg
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Phytochemical evaluation of Cucumis prophetarum: protective effects against carrageenan-induced prostatitis in rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-22 Omar Saad Aljohani
Abstract Phytochemical study of the MeOH extract of Cucumis prophetarum fruits (family Cucurbitaceae) by using different chromatographic techniques led to the isolation of three metabolites; spinasterol (1), cucurbitacin B (2), and 2-O-β-D-glucopyranosylcucurbitacin E (3). Their chemical structures were created on the basis of physical, chemical, spectroscopic data 1D (1H and 13C NMR), and 2D NMR (HSQC
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Tempol (4-hydroxy tempo) protects mice from cisplatin-induced acute kidney injury via modulation of expression of aquaporins and kidney injury molecule-1 Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-20 Mohd Amir Afjal; Poonam Goswami; Shahzad Ahmad; Sadaf Dabeer; Juheb Akhter; Mohd Salman; Anuradha Mangla; Sheikh Raisuddin
Abstract Tempol (4-hydroxy tempo), a pleiotropic antioxidant is reported to afford protection against cisplatin (CP)-induced nephrotoxicity. However, molecular mechanisms of action of tempol in improving the renal function in CP-induced nephrotoxicity are not fully understood. We investigated the attenuating effect of tempol against CP-induced alterations in kidney injury molecule-1 (KIM-1) and aquaporins
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Centella asiatica prevents D-galactose-Induced cognitive deficits, oxidative stress and neurodegeneration in the adult rat brain Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-20 Zeba Firdaus; Neha Singh; Santosh Kumar Prajapati; Sairam Krishnamurthy; Tryambak Deo Singh
Abstract Chronic D-galactose (D-gal) administration causes cognitive impairment and is used widely in animal models for anti-aging studies. Centella asiatica (CA), a traditional herbal medicine, has been used as a brain tonic to enhance memory. This study evaluates the neuroprotective role of an ethanolic extract of Centella asiatica (CAE) against D-gal-induced aging in rats. Healthy male rats were
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Sub-chronic and chronic toxicity evaluation of 7-methylxanthine: a new molecule for the treatment of myopia Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-19 Harjeet Singh; Harmanpreet Singh; Nikhil Shri Sahajpal; Surinder Paul; Inderjit Kaur; Subheet Kumar Jain
Abstract Myopia (nearsightedness) is a vision disorder with a blurring of far objects, affect millions worldwide. 7-methylxanthine (7-MX) is a molecule that is presently under clinical investigation for the treatment of myopia. In the present study, we have investigated sub-chronic and chronic toxicity of 7-MX in comparison to other clinically used methylxanthines i.e., caffeine and theobromine as
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In-vivo and in-silico toxicity studies of daidzein: an isoflavone from soy Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-15 Ankit P. Laddha; S. Murugesan; Yogesh A. Kulkarni
Abstract Daidzein is a naturally occurring compound belonging to the class isoflavones and found in soya beans and other legumes. Acute oral toxicity was performed as per OECD guideline (TG 423) with slight modifications. A repeated dose toxicity study was carried out as per OECD guideline (TG 407). In-silico toxicity such as AMES toxicity, carcinogenicity, mutagenicity, immunotoxicity, hepatotoxicity
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Hot-processed virgin coconut oil abrogates cisplatin-induced nephrotoxicity by restoring redox balance in rats compared to fermentation-processed virgin coconut oil Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-15 Arunaksharan Narayanankutty; Soorya Parathodi Illam; Varsha Rao; Sabah Shehabudheen; Achuthan C. Raghavamenon
Abstract Virgin coconut oil (VCO) is a functional food oil prepared from fresh coconut kernel either by hot-processed (HPVCO) or fermentation-processed (FPVCO). The FPVCO has been widely explored for its pharmacological efficacy; while HPVCO, which has traditional uses, is less explored. The present study compared the phenolic content and nephroprotective effect of both these oils in male Wistar rats
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The beneficial effects of antioxidants combination on cardiac injury induced by tetrachloromethane Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-15 Aliah R. Alshanwani; Laila M. Faddah; Hanan Hagar; Ahlam M. Alhusaini; Sameerah Shaheen; Raeesa A. Mohammad; Fatima M. B. Alharbi; Alaa AlHarthii; Amira M. Badr
Abstract The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injection, significantly mitigated the increases in serum troponin T, creatine kinase-MB
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Hypericin, a medicinal compound from St. John’s Wort, inhibits genotoxicity induced by mutagenic agents in V79 cells Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-13 Larissa Mendes de Souza; Fernanda Diniz de Sousa; Roberta Cristina Ribeiro Cruz; Denise Crispim Tavares; Pollyanna Francielli de Oliveira
Abstract This study evaluated the cytotoxic, genotoxic, and the modulatory effects on DNA damage of hypericin in Chinese hamster lung fibroblasts (V79 cells). The hypericin is a natural polycyclic quinone, mainly extracted from St. John’s Wort (Hypericum perforatum L.). Along with hyperforin, the hypericins are responsible for the antidepressant activity of St. John’s Wort. Cytotoxicity was assessed
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Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-10-01 Ishfaq Shafi Khan; Khalid Bashir Dar; Showkat Ahmad Ganie; Md. Niamat Ali
Abstract Sodium benzoate is a widely used food and pharmaceutical preservative due to its antibacterial and antifungal activity. In the present study effect of different concentrations of sodium benzoate on hepatic antioxidants, inflammatory cytokines (TNF-α, IFN-γ, IL-1β and IL-6), biochemical markers and histopathology of liver was evaluated. Twenty five adult rats (aged 1–2 months) with 5 rats per
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Regular use of ibuprofen reduces rat penile prostaglandins and induces cavernosal fibrosis. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-23 Abdel Aaal Elkamshoushi,Passainte Hassaan,Iman Nabil,Heba Ossama,Salma S Omar
Ibuprofen is a commonly used non-steroidal anti-inflammatory drug that is noted for its favorable safety profile. It exerts its therapeutic effect through inhibition of prostaglandin (PG) production at inflammatory sites. However, the inhibition of PG synthesis at other sites is responsible for the occurrence of adverse events. Evidence regarding the effect of regular ibuprofen intake on penile PG
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Evaluation of non-clinical toxicity of extract and vouacapans from fruits of Pterodon pubescens Benth. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-23 Vanessa Helena da Silva Souza,Rosanna Tarkany Basting,Ilza Maria de Oliveira Sousa,Núbia de Cássia Almeida Queiroz,João Ernesto de Carvalho,Mary Ann Foglio
Pterodon pubescens Benth. is widely used in folk medicine for the treatment of inflammatory conditions, with the activity attributed to the compounds with a vouacapan moiety, however, few studies report the toxicological evaluation of the extract and safety issues related to the species. Herein the non-clinical toxicity, in in vivo and in vitro tests, of dichloromethane crude extract of Pterodon pubescens
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The protective effect of Morin against ifosfamide-induced acute liver injury in rats associated with the inhibition of DNA damage and apoptosis. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-22 Selçuk Özdemir,Sefa Kucukler,Selim Çomaklı,Fatih Mehmet Kandemir
Morin is a flavonoid and broadly found in white berry and cranberry branch. Ifosfamide (IFOS) is known as an anticancer and cytotoxic drug especially on the liver. This study aimed to explore the potential protective effects of Morin against IFOS-induced liver toxicity in rats. The model group of rats received a single injection of IFOS (500 mg/kg; i.p.) at day 2, whereas the protective groups of rats
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Azithromycin effects on the European sea bass (Dicentrarchus labrax) early life stages following acute and chronic exposure: Laboratory bioassays. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-22 Lazhar Mhadhbi,Tahani El Ayari,Meriam Tir,Dorra Kadri
The purpose of this study was to assess the acute and chronic effects of the macrolide azithromycin (AZI) on the European sea bass (Dicentrarchus labrax) early life stages. Azithromycin is a semi-synthetic antibiotic frequently detected in the aquatic environment, despite this few information about its effects on aquatic organisms were reported. Investigations of AZI acute toxicity on D. labrax early
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Neuromodulatory and oxidative stress evaluations in African catfish Clarias gariepinus exposed to antipsychotic drug chlorpromazine. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-22 Chinedu Ifeanyi Atama,Excellence Chidera Nnaji,Ifeanyi Christian Ezeoyili,Faith Okwukwe Udeani,Chioma Juliet Onovo,Nelson Ike Ossai,Ifeanyi Oscar Aguzie,Christopher Didigwu Nwani
Chlorpromazine (CPZ) is among the most famous drugs used for the treatment of psychosis such as delusions, hallucinations, schizophrenia, paranoia, or disordered thought in humans. In the present study, the acetylcholinesterase (AChE) activity and oxidative stress parameters in the brain of Clarias gariepinus juveniles exposed to CPZ were investigated. Fish were exposed to 0.53, 1.56, and 2.11 mg/L
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Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-14 Vadivel Dinesh Babu,Anandasadagopan Suresh Kumar,Ganapasam Sudhandiran
Idiopathic Pulmonary Fibrosis (IPF) is a grave disease characterized by abnormal wound healing associated with chronic, progressive, irreversible fatal lung disease, leading to persistent injuries to the alveolar epithelium. A consequent disturbance of fibroblast proliferation and apoptosis results in subsequent release of pro-inflammatory and pro-fibrotic mediators coupled with accumulation of extracellular
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The evaluation of hepatoprotective effects of flavonoids from Scorzonera austriaca Wild against CCl4-induced acute liver injury in vitro and in vivo. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-14 Enwei Wei,Sixi Zhang,Jinghui Zhai,Sitong Wu,Guangshu Wang
Scorzonera austriaca Wild is a traditional herbal medicine; however, little is known with regard to the effect of flavonoids from S. austriaca (FSA) on liver injury induced by Carbon tetrachloride (CCl4), especially the mechanism remains unknown. Therefore, our paper was designed to investigate the hepatoprotective effect of FSA against CCl4-induced acute liver injury in vitro and in vivo, with focus
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Hepatotoxic effect of lead and hepatoprotective effect of Hydrilla verticillata on hepatic transcriptional and physiological response in edible fish Labeo rohita. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-09 Pandi Prabha S,Johanna Rajkumar,Karthik C
Lead tops the list of developmental toxicants released by industry into the environment according to Commission for Environmental Corporation. Hydrilla verticillata is an aquatic weed and rich source of variable nutrients and chemical constituents like saponins, vitamins, minerals, antioxidants, amino acids, detoxifying agents, etc. This weed is used in a beneficial way to detoxify lead in fish model
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Exposure to pyrethroids induces behavioral impairments, neurofibrillary tangles and tau pathology in Alzheimer's type neurodegeneration in adult Wistar rats. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-09 K A Iteire,A T Sowole,B Ogunlade
This study investigated the exposure of pyrethroids in the development of Alzheimer’s type neurodegeneration by analyzing β- amyloid, tau and Glial Fibrillary Acidic Protein (GFAP) in adult Wistar rats. Forty adult Wistar rats (130–150 g) of both sexes were assigned into five groups (n = 8). Groups A-C were treated with three different sub-lethal doses (75, 50 and 25%)of the pyrethroids formulation
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Selenium and L-carnitine protects from valproic acid-Induced oxidative stress and mitochondrial damages in rat cortical neurons. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-04 Ahmad Salimi,Nasrin Alyan,Nasim Akbari,Zhaleh Jamali,Jalal Pourahmad
Oxidative stress and mitochondrial dysfunction have been associated with valproic acid (VPA) induced neurotoxicity. Mitochondria are vulnerable to oxidative damage and are also a major source of superoxide free radicals. Therefore, the need for mitochondrial protective and antioxidant agents for reducing valporic acid toxicity in central nerve system (CNS) is essential. In the present study, we investigated
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Alogliptin attenuates cyclophosphamide-induced nephrotoxicity: a novel therapeutic approach through modulating MAP3K/JNK/SMAD3 signaling cascade. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-09-01 Rania M Salama,Merihane M Nasr,Jannatullah I Abdelhakeem,Omar K Roshdy,Mohamed A ElGamal
Cyclophosphamide (CP) is widely used as a chemotherapy against various types of cancers. However, CP is accompanied with multiple organ toxicity due to production of reactive oxygen species (ROS), induction of inflammation and consequently apoptosis. Alogliptin (Alo) is a dipeptidyl peptidase 4 (DPP-IV) inhibitor, which is booming as an antidiabetic agent. Interestingly, gliptins are currently studied
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Standardized aqueous stem bark extract of Gmelina arborea roxb. possesses nephroprotection against adriamycin-induced nephrotoxicity in Wistar rats. Drug Chem. Toxicol. (IF 2.405) Pub Date : 2020-08-30 Sachinthi S Amarasiri,Anoja P Attanayake,Liyanagae D A M Arawwawala,Kamani A P W Jayatilaka,Lakmini K B Mudduwa
Nephrotoxicity is a major limitation of adriamycin (ADR) chemotherapy. We hypothesized that administration of standardized aqueous bark extract of Gmelina arborea Roxb. (GA) (Family; Verbenaceae), a traditional therapeutic agent, may reduce the nephrotoxicity caused by ADR in Wistar rats. The dose-dependent nephroprotective activity of the standardized GA extract was investigated in ADR-induced (20 mg/kg
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