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Charging Ahead: Examining the Future Therapeutic Potential of Electroceuticals Adv. Therap. (IF 4.6) Pub Date : 2024-03-16 Swarna Balasubramanian, David Weston, Michael Levin, Devon Charles Cardoso Davidian
Electroceuticals derived from electronic and pharmaceuticals is a term coined to describe the therapeutic manipulation of neuronal signaling. In recent years, the sophistication and range of applications of electroceuticals has grown considerably. In this Review we therefore suggest a revised ontology and framework for defining electroceuticals that broadens the concept beyond neuron‐targeted interventions
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Correction to “Identification of HLA‐restricted cytotoxic T lymphocyte epitopes of B cell maturation antigen as promising peptide vaccine candidates for preventive and therapeutic strategies in multiple myeloma” Adv. Therap. (IF 4.6) Pub Date : 2024-03-16
Advanced Therapeutics, Volume 7, Issue 2, 2300208 DOI: https://doi.org/10.1002/adtp.202300208 The following corrections to this paper should be noted. We have identified an error in the spelling of one coauthor's first name. The correct spelling is “Sanya Sukpanichnant,” not “Sunya Sukpanichnant” as originally published.
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Oncolytic Viruses in Cancer Immunotherapy Adv. Therap. (IF 4.6) Pub Date : 2024-03-11 Xiao Li, Zhongping Cheng
Oncolytic viruses are novel and promising therapeutic regimens that promote antitumor efficacy through multimode mechanisms, including direct lysis of tumor cells, release of the tumor antigens and danger signals, induction of immunological cell death, activation of innate and adaptive immune response. In addition, oncolytic viruses can be engineered to express virus‐centered and immune‐centered therapeutic
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Clinical and Translational Opportunities of Nanocarriers Containing RNAi for the Management of Triple‐Negative Breast Cancer Adv. Therap. (IF 4.6) Pub Date : 2024-03-11 Saurabh Sharma, Rajesh Pradhan, David Lee, Mahalaxmi Sharma, Shima Zahed Nasab, Siddhanth Hejmady, Subash C Chander, Neda Mohaghegh, Surjendu Maity, Shahid Khan, Ali Khademhosseini, Amanda Kirane
Triple‐negative breast cancer (TNBC) develops from malignant cells within the interior lining of milk ducts or, less frequently, in the stromal tissues and accounts for around 15% of all breast cancers. Breast cancer is highly prevalent with the overall number of cases expected to reach 27.78 million by 2040, according to the World Health Organization (WHO). MiRNAs serve a novel role in management
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A Feasibility Test of the Disposable Drug Daughter Plate Combined with 384-Pillar Plate for Patient-Derived Organoid-Based High Throughput Screening Adv. Therap. (IF 4.6) Pub Date : 2024-03-09 Kyunghyun Park, Ji-O. Ryu, Gayeon Kim, Bosung Ku, Yongmun Choi, Ji-Youn Lee, Sang-Yun Lee, Dong Woo Lee
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Stable IL‐2 Nano‐Assembly for Improved Anti‐Tumor Effect (Adv. Therap. 3/2024) Adv. Therap. (IF 4.6) Pub Date : 2024-03-07 Yudong Liu, Wenfeng Zeng, Wenjing Na, Xiuli Wei, Kai Song, Youwang Wang, Ping Zhu, Hao Wang, Wei Liang
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Hydrogels of Alginate Derivative-Encased Nanodots Featuring Carbon-Coated Manganese Ferrite Cores with Gold Shells to Offer Antiangiogenesis with Multimodal Imaging-Based Theranostics Adv. Therap. (IF 4.6) Pub Date : 2024-03-05 Pemula Gowtham, Koyeli Girigoswami, Alex Daniel Prabhu, Pragya Pallavi, Anbazhagan Thirumalai, Karthick Harini, Agnishwar Girigoswami
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Engineering MnO2 Nanomulberries for Enhancing PTT/PDT Synergistic Cancer Therapy Adv. Therap. (IF 4.6) Pub Date : 2024-03-04 Lili Chen, Han Wang, Tao Zhan, Xiumei Yuan, Xiaoru Ma
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Evaluation of Bioprinted Autologous Cartilage Grafts in an Immunocompetent Rabbit Model Adv. Therap. (IF 4.6) Pub Date : 2024-03-04 David Gvaramia, Philipp Fisch, Killian Flégeau, Lena Huber, Johann Kern, Yvonne Jakob, Daniela Hirsch, Nicole Rotter
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Type-I-Organic-Photosensitizer-Functionalized Upconversion Nanoparticles for Enhanced Photodynamic Therapy Adv. Therap. (IF 4.6) Pub Date : 2024-02-28 Yilin Liu, Haiyang Wang, Fangfang Ke, Xiaoyu Ji, Nipeng Chen, Kaimin Zhang, Zhiyong Yang, Yongming Chen, Zhen Zhang
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Nanoparticle-Mediated Tumor Microenvironment Remodeling Favors the Communication with the Immune Cells for Tumor Killing Adv. Therap. (IF 4.6) Pub Date : 2024-02-23 Elena Lucena-Sánchez, Francisco J. Hicke, Sandra Clara-Trujillo, Alba García-Fernández, Ramón Martínez-Máñez
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An Overview Of Advancements And Technologies In Vascularization Strategies For Tumor‐On‐A‐Chip Models Adv. Therap. (IF 4.6) Pub Date : 2024-02-22 Pratibha Parihar, Naina Sunildutt, Chethikkattuveli Salih Abdul Rahim, Anupama Samantasinghar, Jong Hwan Lim, Kyung Hyun Choi
Vascularized tumor on a chip (VToC) entails emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer a faithful representation of cancer in vitro, exploration of tumor biology, evaluation of drug efficacy, and anticipation of patient responses to therapies. Compared to conventional ones, VToC systems hold advantages
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Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease Adv. Therap. (IF 4.6) Pub Date : 2024-02-22 Shuyuan Guo, Zhuxia Zhang, Bingxuan Xu, Mengxin Wang, Taojian Fan, Xinliang Zhong, Azhen Hu, Die Hu, Lan Luo, Shuping Lin, Linlin Wang, Rongquan Yao, Jiabao Huang, Huiying Hu, Xintao Shuai, Jie Shi, Yun Chen, Tingting Zheng
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Phosphonated Heptamethine Dye Alleviates Radiation-Induced Bone Loss Adv. Therap. (IF 4.6) Pub Date : 2024-02-20 Lei Long, Feng Wu, Huijuan Li, Xiaohui Cao, Yu Wang, Xu Tan, Chunmeng Shi
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Preclinical Toxicity Assessment of Ti-Based MXene Nanomaterials for Advanced Theranostic Applications Adv. Therap. (IF 4.6) Pub Date : 2024-02-09 Barkha Singh, Rohan Bahadur, Deepika Rai, Rohit Srivastava
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Cold Atmospheric Plasma: An Emerging Immunomodulatory Therapy Adv. Therap. (IF 4.6) Pub Date : 2024-02-08 Hui Liu, Xiaoliu Liang, Minglei Teng, Zhenjie Li, Yisheng Peng, Peiyu Wang, Hu Chen, Hongwei Cheng, Gang Liu
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Alginate-Coated Silicone Implants with Anti-solvent Crystallized Paclitaxel to Prevent Breast Cancer Recurrence and Reduce Fibrosis Adv. Therap. (IF 4.6) Pub Date : 2024-01-26 Noehyun Myung, Seoyoung Hwang, Won Ha, Hyun-Wook Kang
Breast cancer patients undergoing mastectomy receive silicone implant-based breast reconstruction to mitigate the psychological distress of breast loss, typically in conjunction with adjuvant therapy. However, significant problems remain, such as systemic toxicity from chemotherapy and fibrosis that causes capsular contracture. Here, we report the development of a silicone implant coated with an alginate
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A 3D In Vitro Triculture Hybrid Model Recapitulating Tumor Stromal Interaction of Triple-Negative Breast Cancer as a High Throughput Anticancer Drug Screening Platform Adv. Therap. (IF 4.6) Pub Date : 2024-01-26 Chitra Jaiswal, Biman B. Mandal
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Application of Cell Membrane Vesicles in Cancer Diagnosis and Treatment Adv. Therap. (IF 4.6) Pub Date : 2024-01-25 Yun Cheng, Haoan Wu, Ming Ma, Yu Zhang
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Biomaterial-Facilitated Local Delivery of Stem Cell-Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy Adv. Therap. (IF 4.6) Pub Date : 2024-01-24 Fei Tan, Maoxiang Xu, Xuran Li, Zhao Wang, Jiaojiao Li, Khawar Ali Shahzad
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A Spatial Transcriptomics Based Label-Free Method for Assessment of Human Stem Cell Distribution and Effects in a Mouse Model of Lung Fibrosis Adv. Therap. (IF 4.6) Pub Date : 2024-01-24 Jeongbin Park, Dongjoo Lee, Jae Eun Lee, Daeseung Lee, In Ho Song, Hyun Soo Park, Hongyoon Choi, Hyung-Jun Im
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Nano-Mediated PDT as a Multifunctional Immunomodulatory Agent in the Intricate Milieu of Melanoma Adv. Therap. (IF 4.6) Pub Date : 2024-01-21 Aya A. Sebak, Mohammad Abdel-Halim, Mostafa Abdelrahman, Gehad Mohamed, Tarek El-Tayeb, Iman Gomaa
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Therapeutic Hydrogels (Adv. Therap. 1/2024) Adv. Therap. (IF 4.6) Pub Date : 2024-01-16 Matthew J. Webber, Jaeyun Kim, Patricia Y.W. Dankers
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Prodrug Celecoxib-Derived Nanoparticles Potentiate the Efficacy of Cancer Immunotherapy by Remodeling the Tumor Microenvironment Adv. Therap. (IF 4.6) Pub Date : 2024-01-15 Tae Woo Kim, Chang-Hee Whang, Dohyeon Kim, Sangyong Jon
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Discovery of Broad-Spectrum Repurposed Drug Combinations Against Carbapenem-Resistant Enterobacteriaceae (CRE) Through Artificial Intelligence (AI)-Driven Platform Adv. Therap. (IF 4.6) Pub Date : 2024-01-12 Ming Li, Kui You, Peter Wang, Lissa Hooi, Yahua Chen, Anqi Siah, Shi-Bei Tan, Jeanette Teo, Oon-Tek Ng, Kalisvar Marimuthu, Indumathi Venkatachalam, Agata Blasiak, Edward Kai-Hua Chow, Dean Ho, Yunn-Hwen Gan
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In Vitro Assessment of Protamine Toxicity with Neural Cells, Its Therapeutic Potential to Counter Chondroitin Sulfate Mediated Neuron Inhibition, and Its Effects on Reactive Astrocytes Adv. Therap. (IF 4.6) Pub Date : 2024-01-10 Derek W. Nelson, Jessica L. Funnell, Conrad H. Cheung, Geraldine B. Quinones, Christina S. Mendoza, Marvin Bentley, Ryan J. Gilbert
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Hybrid Milk Extracellular Vesicles as Potential Systems for Oral Delivery of siRNA Adv. Therap. (IF 4.6) Pub Date : 2024-01-09 Yunyue Zhang, Xiang Luo, Ning Ding, Mona Belaid, Maya Thanou, Driton Vllasaliu
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Single-Cell Transcriptomic Analysis Reveals the Alleviating Effect of Anemoside B4 on Murine Diabetic Nephropathy Adv. Therap. (IF 4.6) Pub Date : 2024-01-08 Chunting Zhang, Qian Zhang, Piao Luo, Jing Liu, Wentong Zhao, Xueying Liu, Junmao Li, Huanhuan Pang, Xiaoran Li, Shilin Yang, Hongwei Gao, Yulin Feng, Jigang Wang
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Microneedles-Mediated Intradermal Delivery of Paclitaxel/Anti-PD-1 for Efficient and Safe Triple-Negative Breast Cancer Therapy Adv. Therap. (IF 4.6) Pub Date : 2023-12-29 Jiachen Wang, Ting Wen, Hangping Chen, Sicong Huang, Rui Guo, Yanfang Zheng, Zecong Xiao, Xintao Shuai
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Injectable Hydrogel Incorporated with Iron-Doped Carbon Dots Exhibiting Peroxidase-Like Activity for Antibacterial Therapy and Wound Healing Adv. Therap. (IF 4.6) Pub Date : 2023-12-28 Tianliang Li, Lixing Lin, Dong Wang, Haowen Fang, Zhiwei Zhang, Yitong Wang, Yingying Chen, Lingyan Feng
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CURATE.AI—Artificial Intelligence-Derived Personalized Tacrolimus Dosing for Pediatric Liver Transplant: A Retrospective Study Adv. Therap. (IF 4.6) Pub Date : 2023-12-25 Shi-Bei Tan, Kirthika Senthil Kumar, Tiffany Rui Xuan Gan, Lester W. J. Tan, Anh T. L. Truong, Agata Blasiak, Marion M. Aw, Vidyadhar Padmakar Mali, Dean Ho
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Accelerating Diabetic Wound Healing by Modulating the Inflammatory Environment Using Quercetin–Rosemary Oil Lipid Nanoemulsions with Artificial Intelligence-Based Wound Closure Analysis Adv. Therap. (IF 4.6) Pub Date : 2023-12-20 Mohammad Sadik Ali, Monika Pebam, Hima Sree Buddhiraju, Sreenath Dey, Veeresh Bantal, Nagarajan Ganapathy, Divyadarshini Madhavan, Aravind Kumar Rengan
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Engineering Living Immunotherapeutic Agents for Improved Cancer Treatment Adv. Therap. (IF 4.6) Pub Date : 2023-12-18 Tinotenda Gwisai, Sina Günther, Nima Mirkhani, Matej Vizovisek, Stefano Menghini, Mira Jacobs, Michael G. Christiansen, Ines Oberhuber, Pascal Poc, Simone Schuerle
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Porphyrin-Based Nanozymes for Biomedical Applications Adv. Therap. (IF 4.6) Pub Date : 2023-12-18 Erli Cheng, Bowen Li, Qianli Zou
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A Versatile Nanoemulsion of Antibiotic and Eucalyptol with Synergistic Effects Against E. Coli Infected Urocystitis Adv. Therap. (IF 4.6) Pub Date : 2023-12-15 Honglei Guo, Tianyu Lan, Jun Qian, Yongjun Luo, Xinxin Tian, Hao Yin, Hui Xu, Hongqing Cui, Xiangchun Shen, Qianqian Guo
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Responsive Nanomaterial Delivery Systems for Pancreatic Cancer Management Adv. Therap. (IF 4.6) Pub Date : 2023-12-15 Amr Elsherbeny, Hulya Bayraktutan, Umut Can Oz, Cara Moloney, Jennifer C. Ashworth, Anna M. Grabowska, Cameron Alexander
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Pharmacokinetics and Biodistribution of Phages and their Current Applications in Antimicrobial Therapy Adv. Therap. (IF 4.6) Pub Date : 2023-12-13 Dayeon Kang, Damayanti Bagchi, Irene A. Chen
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Enhanced Anti-Photoaging Effects of Adipose-Derived Stem Cell (ADSC) Secretome via Liposomal and Iontophoretic Intradermal Delivery Adv. Therap. (IF 4.6) Pub Date : 2023-12-13 Eunhye Shin, Jeong-Uk Kim, Junghyeon Ko, Rachel H. Koh, Junhee Kim, Su-Bin Park, Young-Hyeon An, Nathaniel S. Hwang
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From Theory to Therapy: The Advancements of Extracellular Vesicles in Immunotherapy Adv. Therap. (IF 4.6) Pub Date : 2023-12-07 Nils Piernitzki, Oskar Staufer
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Superior Effectiveness of PD-1 Inhibitor Plus Chemotherapy versus Bevacizumab Plus Chemotherapy as First-Line Treatment for Non-Small Cell Lung Cancer with Brain Metastases Adv. Therap. (IF 4.6) Pub Date : 2023-12-07 Hui Yu, Jing Chen, Meichen Li, Baishen Zhang, Bei Zhang, Likun Chen
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Therapeutic Hydrogels Adv. Therap. (IF 4.6) Pub Date : 2023-12-05 Matthew J. Webber, Jaeyun Kim, Patricia Y.W. Dankers
We are pleased to present a joint special issue spanning Advanced Therapeutics and Macromolecular Bioscience to highlight progress in the use of hydrogel biomaterials for therapeutic applications. Hydrogels have been broadly explored as functional biomaterials; their three-dimensional highly hydrated porous architecture captures features of native extracellular matrix, offering surrogate substrates
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Melt Electrowriting: A Promising 3D Printing Technology for Cartilage and Osteochondral Repair Adv. Therap. (IF 4.6) Pub Date : 2023-12-04 Sha Zhou, Jiyao Xing, Li Sun, Xiao Hu, Ting Liu, Qing Liu, Zongying Zhang, Minglu Hao, Bing Liang, Dongming Xing
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Hydrogel-Based Delivery of antimiR-195 Improves Cardiac Efficacy after Ischemic Injury Adv. Therap. (IF 4.6) Pub Date : 2023-12-04 Joep E. C. Eding, Marta Vigil-Garcia, Marit Vink, Charlotte J. Demkes, Danielle Versteeg, Lieneke Kooijman, Maarten H. Bakker, Maaike J. G. Schotman, Patricia Y. W. Dankers, Eva van Rooij
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Mussel-Inspired Recombinant Adhesive Protein-Based Functionalization for Consistent and Effective Antimicrobial Treatment in Chronic Inflammatory Skin Diseases Adv. Therap. (IF 4.6) Pub Date : 2023-12-03 Suhyeon Kim, Nam Hyeong Kim, Zinah Hilal Khaleel, Deok Hyang Sa, Daekyu Choi, Seongmin Ga, Chang Geon Kim, Jiye Jang, Kyeonghyun Kim, Ye Ji Kim, Sukkum Ngullie Chang, Seon Min Park, Su Yeon Park, Bok-Soo Lee, Jin-Chul Kim, Jaecheol Lee, Seongpil An, Jae Gyu Park, Yong Ho Kim
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Homologous Targeting and Adhesion Abilities of Cellular Microvesicles for Enhanced Intravesical Therapy of Bladder Cancer Adv. Therap. (IF 4.6) Pub Date : 2023-11-23 Fan Qi, Lulu Wang, Luopeng Bi, Xiaoqing Han, Jiao Yan, Pangpan Song, Xingbo Wan, Yanjing Wang, Yaqing Kang, Xiaobo Ding, Yanbo Wang, Haiyuan Zhang
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Cobra Hemagglutinin and cGAMP Loaded Ace-Dex Microparticles Provide a Broadly Active and Shelf-Stable Influenza Vaccine Platform Adv. Therap. (IF 4.6) Pub Date : 2023-11-20 Dylan A. Hendy, Erik S. Pena, Cole J. Batty, Luis Ontiveros-Padilla, John A. Roque III, Timothy A. Dixon, Denzel D. Middleton, Michael A. Carlock, Ted M. Ross, Eric M. Bachelder, Kristy M. Ainslie
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Identification of HLA-restricted Cytotoxic T Lymphocyte Epitopes of B Cell Maturation Antigen as Promising Peptide Vaccine Candidates for Preventive and Therapeutic Strategies in Multiple Myeloma Adv. Therap. (IF 4.6) Pub Date : 2023-11-20 Wannasiri Chiraphapphaiboon, Piriya Luangwattananun, Thaweesak Chieochansin, Danai Samutpradit, Pranaidej Hengswat, Phurin Areesawangkit, Ployploen Phikulsod, Nuttavut Sumransub, Sunya Sukpanichnant, Mutita Junking, Pa-thai Yenchitsomanus
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Multidisciplinary Approaches in the Treatment of Retinal Degenerative Diseases: A Review Adv. Therap. (IF 4.6) Pub Date : 2023-11-20 Jianqi Chen, Xiaohua Zhuo, Yingting Zhu, Yehong Zhuo
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Mifepristone Modulates the Polarization of Th1/Th2 by Inducing the Mature of Monocyte-Derived Dendritic Cells Adv. Therap. (IF 4.6) Pub Date : 2023-11-14 Yinghua Li, Li Li, Songyi Li, Chaying He
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Magnetic Mesoporous Janus Microrollers for Combined Chemo- and Photothermal Ablation Therapy Adv. Therap. (IF 4.6) Pub Date : 2023-11-10 Gulsen Aybar Tural, Ugur Bozuyuk, Nihal Olcay Dogan, Yunus Alapan, Mukrime Birgul Akolpoglu, Amirreza Aghakhani, Jelena Lazovic, Ozgen Ozer, Metin Sitti
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Copper Coordination-Based Nanomedicine for Tumor Theranostics Adv. Therap. (IF 4.6) Pub Date : 2023-11-10 Yuanfeng Han, Nuli Xie, Wenhu Zhou
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Biomedical Applications of Cell Membrane-Based Biomimetic Nano-Delivery System Adv. Therap. (IF 4.6) Pub Date : 2023-11-04 Dexin Zhang, Guodong Wang, Ningyi Ma, Ziyang Yuan, Yuqin Dong, Xin Huang, Haishi Qiao, Ke Ren
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Sodium Butyrate Regulates Gasdermin B Exerted Protection Effect on the MTX-Induced NCM460 and Hum Cells Adv. Therap. (IF 4.6) Pub Date : 2023-11-03 Chensheng Jiang, Yang Liu, Hangping Chen, Yifan Qian, Leilei Tang, Channi Wu, Tiemei Han, Chengfeng Jin, Haihong Ju, Xiaofeng Shen, Jiawen Yu, Lingdi Zhang, Yiyang Dai, Guojun Jiang
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Fam20C Kinase as a Key Regulator of Bevacizumab Resistance in Mesenchymal Glioblastoma Adv. Therap. (IF 4.6) Pub Date : 2023-10-30 Chan Il Kim, Sooheon Kim, Seong-Min Park, Sung Soo Kim, Hyung Joon Kwon, Weiwei Lin, Saewhan Park, Seokjun Ha, Kyung Hee Ha, Sanha Park, Seung Min Park, Tae Hoon Kim, Kyung-Hee Kim, Yun-Hee Kim, Jong Heon Kim, Jong Bae Park
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In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery Adv. Therap. (IF 4.6) Pub Date : 2023-10-26 Claire Rennie, Caitlin Sives, India Boyton, Dennis Diaz, Catherine Gorrie, Orazio Vittorio, Lyndsey Collins-Praino, Andrew Care
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Functionalized Chitosan Decorated Hafnium Oxide@Gold Core–Shell Nanoparticles for Multimodal Cancer Therapy Adv. Therap. (IF 4.6) Pub Date : 2023-10-23 Aastha Gupta, Ankur Sood, Dimpy Bhardwaj, Nishith Shrimali, Ritu Singhmar, Shubhra Chaturvedi, Prasenjit Guchhait, Garima Agrawal
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MicroRNA-Responsive DNA Dendrimer Acts as a Smart STING Signal Amplifier (Adv. Therap. 10/2023) Adv. Therap. (IF 4.6) Pub Date : 2023-10-19 Rong Wu, Yi Xue, Jiayin Zhan, Zhiyuan Feng, Jun-Jie Zhu, Jingjing Zhang
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Xenogeneic Serum-Free Human Cell-Derived Tissue Engineered Matrices for the Development of Clinical-Grade Biomimetic Cardiovascular Devices (Adv. Therap. 10/2023) Adv. Therap. (IF 4.6) Pub Date : 2023-10-19 Polina Zaytseva, Valery L. Visser, Arian Ehterami, Simon P. Hoerstrup, Sarah E. Motta, Maximilian Y. Emmert
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Degradable Microneedle Patch Loaded with Doxycycline Hydrochloride and Vascular Endothelial Growth Factors for Promoting Diabetic Wound Healing Adv. Therap. (IF 4.6) Pub Date : 2023-10-21 Yufang Tan, Yichen Wang, Ning Zeng, Qi Zhang, Min Wu, Yiping Wu