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Phenolic Profiles, Antioxidant Activity and Phenotypic Characterization of Lonicera caerulea L. Berries, Cultivated in Lithuania Antioxidants (IF 5.014) Pub Date : 2021-01-15 Lina Raudonė; Mindaugas Liaudanskas; Gabrielė Vilkickytė; Darius Kviklys; Vaidotas Žvikas; Jonas Viškelis; Pranas Viškelis
Lonicera caerulea L. is an early fruit-bearing plant that originates from harsh environments. Raw materials contain a body of different phenolic origin compounds that determine the multidirectional antioxidant and pharmacological activities. The aim of this study was to comprehensively evaluate the phenolic composition, antioxidant capacities, vegetative, pomological, and sensory properties and their
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Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers Antioxidants (IF 5.014) Pub Date : 2021-01-15 Pahriya Ashrap; Deborah J. Watkins; Ginger L. Milne; Kelly K. Ferguson; Rita Loch-Caruso; Jennifer Fernandez; Zaira Rosario; Carmen M. Vélez-Vega; Akram Alshawabkeh; José F. Cordero; John D. Meeker
Metal exposure has been associated with a wide range of adverse birth outcomes and oxidative stress is a leading hypothesis of the mechanism of action of metal toxicity. We assessed the relationship between maternal exposure to essential and non-essential metals and metalloids in pregnancy and oxidative stress markers, and sought to identify windows of vulnerability and effect modification by fetal
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Effects of Fruit and Vegetable-Based Nutraceutical on Cognitive Function in a Healthy Population: Placebo-Controlled, Double-Blind, and Randomized Clinical Trial Antioxidants (IF 5.014) Pub Date : 2021-01-15 Juan Ángel Carrillo; Raúl Arcusa; María Pilar Zafrilla; Javier Marhuenda
There is scientific evidence of the positive effect of polyphenols from plant foods on cognition, but not enough is known about the synergistic effect when multiple polyphenols are consumed and even less in a healthy non-elderly population. The aim of the present study is to investigate the possible effects of improvements in cognitive function in healthy people as a preparation based on micronized
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Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Juglans regia L.) Septum Extract Rich in Bioactive Compounds Antioxidants (IF 5.014) Pub Date : 2021-01-15 Ionel Fizeșan; Marius Emil Rusu; Carmen Georgiu; Anca Pop; Maria-Georgia Ștefan; Dana-Maria Muntean; Simona Mirel; Oliviu Vostinaru; Béla Kiss; Daniela-Saveta Popa
The antitussive, antioxidant, and anti-inflammatory effects of a walnut (Juglans regia L.) septum extract (WSE), rich in bioactive compounds were investigated using the citric acid aerosol-induced cough experimental model in rodents. Wistar male rats were treated orally for three days with distilled water (control), codeine (reference), and WSE in graded doses. On the third day, all rats were exposed
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Effect-Directed Profiling of Powdered Tea Extracts for Catechins, Theaflavins, Flavonols and Caffeine Antioxidants (IF 5.014) Pub Date : 2021-01-15 Gertrud E. Morlock; Julia Heil; Antonio M. Inarejos-Garcia; Jens Maeder
The antioxidative activity of Camelia sinensis tea and especially powdered tea extracts on the market, among others used as added value in functional foods, can considerably vary due to not only natural variance, but also adulteration and falsification. Thus, an effect-directed profiling was developed to prove the functional effects or health-promoting claims. It took 3–12 min per sample, depending
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Extra Virgin Olive Oil Phenolic Extract on Human Hepatic HepG2 and Intestinal Caco-2 Cells: Assessment of the Antioxidant Activity and Intestinal Trans-Epithelial Transport Antioxidants (IF 5.014) Pub Date : 2021-01-15 Martina Bartolomei; Carlotta Bollati; Maria Bellumori; Lorenzo Cecchi; Ivan Cruz-Chamorro; Guillermo Santos-Sánchez; Giulia Ranaldi; Simonetta Ferruzza; Yula Sambuy; Anna Arnoldi; Nadia Mulinacci; Carmen Lammi
In the framework of research aimed at promoting the nutraceutical properties of the phenolic extract (BUO) obtained from an extra virgin olive oil of the Frantoio cultivar cultivated in Tuscany (Italy), with a high total phenols content, this study provides a comprehensive characterization of its antioxidant properties, both in vitro by Trolox equivalent antioxidant capacity, oxygen radical absorbance
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Propagation of Mitochondria-Derived Reactive Oxygen Species within the Dipodascus magnusii Cells Antioxidants (IF 5.014) Pub Date : 2021-01-15 Anton G. Rogov; Tatiana N. Goleva; Khoren K. Epremyan; Igor I. Kireev; Renata A. Zvyagilskaya
Mitochondria are considered to be the main source of reactive oxygen species (ROS) in the cell. It was shown that in cardiac myocytes exposed to excessive oxidative stress, ROS-induced ROS release is triggered. However, cardiac myocytes have a network of densely packed organelles that do not move, which is not typical for the majority of eukaryotic cells. The purpose of this study was to trace the
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Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinson’s Disease Antioxidants (IF 5.014) Pub Date : 2021-01-15 Federica Rey; Sara Ottolenghi; Toniella Giallongo; Alice Balsari; Carla Martinelli; Robert Rey; Raffaele Allevi; Anna Maria Di Giulio; Gian Vincenzo Zuccotti; Serena Mazzucchelli; Roberta Foresti; Michele Samaja; Stephana Carelli
Existing therapies for Parkinson’s disease (PD) are only symptomatic. As erythropoietin (EPO) is emerging for its benefits in neurodegenerative diseases, here, we test the protective effect driven by EPO in in vitro (SH-SY5Y cells challenged by MPP+) and in vivo (C57BL/6J mice administered with MPTP) PD models. EPO restores cell viability in both protective and restorative layouts, enhancing the dopaminergic
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Novel Antioxidant, Deethylated Ethoxyquin, Protects against Carbon Tetrachloride Induced Hepatotoxicity in Rats by Inhibiting NLRP3 Inflammasome Activation and Apoptosis Antioxidants (IF 5.014) Pub Date : 2021-01-15 Igor Y. Iskusnykh; Evgenii D. Kryl’skii; Darya A. Brazhnikova; Tatyana N. Popova; Khidmet S. Shikhaliev; Konstantin K. Shulgin; Larisa V. Matasova; Sergey S. Popov; Dmitry A. Zhaglin; Anastasia A. Zakharova; Nelli R. Popova; Nikolai Fattakhov
Inflammation and an increase in antioxidant responses mediated by oxidative stress play an important role in the pathogenesis of acute liver injury (ALI). We utilized in silico prediction of biological activity spectra for substances (PASS) analysis to estimate the potential biological activity profile of deethylated ethoxyquin (DEQ) and hypothesized that DEQ exhibits antioxidant and anti-inflammatory
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Characterization of TGF-β by Induced Oxidative Stress in Human Trabecular Meshwork Cells Antioxidants (IF 5.014) Pub Date : 2021-01-13 Hsin-Yi Chen; Hsiu-Chuan Chou; Yi-Jung Ho; Shing-Jyh Chang; En-Chi Liao; Yu-Shan Wei; Meng-Wei Lin; Yi-Shiuan Wang; Yu-An Chien; Xin-Ru Yu; Hsiang-Yu Kung; Chu-Chun Yang; Jia-Yu Chen; Hong-Lin Chan; Mei-Lan Ko
Oxidative stress generated by reactive oxygen species (ROS) plays a critical role in the pathomechanism of glaucoma, which is a multifactorial blinding disease that may cause irreversible damage within human trabecular meshwork cells (HTMCs). It is known that the transforming growth factor-β (TGF-β) signaling pathway is an important component of oxidative stress-induced damage related to extracellular
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Nitric Oxide and Hydrogen Sulfide Coordinately Reduce Glucose Sensitivity and Decrease Oxidative Stress via Ascorbate-Glutathione Cycle in Heat-Stressed Wheat (Triticum aestivum L.) Plants Antioxidants (IF 5.014) Pub Date : 2021-01-14 Noushina Iqbal; Shahid Umar; Nafees A. Khan; Francisco J. Corpas
The involvement of nitric oxide (NO) and hydrogen sulfide (H2S) in countermanding heat-inhibited photosynthetic features were studied in wheat (Triticum aestivum L.). Heat stress (HS) was employed at 40 °C after establishment for 6 h daily, and then plants were allowed to recover at 25 °C and grown for 30 days. Glucose (Glc) content increased under HS and repressed plant photosynthetic ability, but
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Investigations into the Role of Metabolism in the Inflammatory Response of BV2 Microglial Cells Antioxidants (IF 5.014) Pub Date : 2021-01-14 Pamela Maher
Although the hallmarks of Alzheimer’s disease (AD) are amyloid beta plaques and neurofibrillary tangles, there is growing evidence that neuroinflammation, mitochondrial dysfunction and oxidative stress play important roles in disease development and progression. A major risk factor for the development of AD is diabetes, which is also characterized by oxidative stress and mitochondrial dysfunction along
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Potential Antioxidant Properties of Enzymatic Hydrolysates from Stichopus japonicus against Hydrogen Peroxide-Induced Oxidative Stress Antioxidants (IF 5.014) Pub Date : 2021-01-14 Hyo-Geun Lee; Hyun-Soo Kim; Jae-Young Oh; Dae-Sung Lee; Hye-Won Yang; Min-Cheol Kang; Eun-A Kim; Nalae Kang; Junseong Kim; Soo-Jin Heo; You-Jin Jeon
A comprehensive antioxidant evaluation was performed on enzymatic hydrolysates of Stichopusjaponicus (S. japonicus) using Vero cells and zebrafish models for in vitro and in vivo studies, respectively. S. japonicus was hydrolyzed with food-grade enzymes (alcalase, α-chymotrypsin, flavourzyme, kojizyme, neutrase, papain, pepsin, protamex, and trypsin), and the free radical scavenging activities were
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Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H2O2 Together with Bicarbonate Antioxidants (IF 5.014) Pub Date : 2021-01-14 Markus Dagnell; Qing Cheng; Elias S.J. Arnér
Protein tyrosine phosphatases (PTPs) can be regulated by several redox-dependent mechanisms and control growth factor-activated receptor tyrosine kinase phosphorylation cascades. Reversible oxidation of PTPs is counteracted by reductive enzymes, including thioredoxin (Trx) and Trx-related protein of 14 kDa (TRP14), keeping PTPs in their reduced active states. Different modes of oxidative inactivation
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Antioxidant Effects of Turmeric Leaf Extract against Hydrogen Peroxide-Induced Oxidative Stress In Vitro in Vero Cells and In Vivo in Zebrafish Antioxidants (IF 5.014) Pub Date : 2021-01-14 Sera Kim; Mingyeong Kim; Min-Cheol Kang; Hyun Hee L. Lee; Chi Heung Cho; Inwook Choi; Yongkon Park; Sang-Hoon Lee
Oxidative stress, caused by the excessive production of reactive oxygen species (ROS), results in cellular damage. Therefore, functional materials with antioxidant properties are necessary to maintain redox balance. Turmeric leaves (Curcuma longa L. leaves; TL) are known to have antioxidant properties, including 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-Azino-di-(3-ethylbenzothiazoline)-6-sulfonic
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Astaxanthin-, β-Carotene-, and Resveratrol-Rich Foods Support Resistance Training-Induced Adaptation Antioxidants (IF 5.014) Pub Date : 2021-01-14 Aki Kawamura; Wataru Aoi; Ryo Abe; Yukiko Kobayashi; Masashi Kuwahata; Akane Higashi
Resistance training adaptively increases the muscle strength associated with protein anabolism. Previously, we showed that the combined intake of astaxanthin, β-carotene, and resveratrol can accelerate protein anabolism in the skeletal muscle of mice. The purpose of this study was to investigate the effect of anabolic nutrient-rich foods on muscle adaptation induced by resistance training. Twenty-six
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Ingredient-Dependent Extent of Lipid Oxidation in Margarine Antioxidants (IF 5.014) Pub Date : 2021-01-13 Sarah Fruehwirth; Sandra Egger; Dennis Kurzbach; Jakob Windisch; Franz Jirsa; Thomas Flecker; Miriam Ressler; Agnes T. Reiner; Nesrin Firat; Marc Pignitter
This study reports the impact of margarine-representative ingredients on its oxidative stability and green tea extract as a promising antioxidant in margarine. Oil-in-water emulsions received much attention regarding factors that influence their oxidative stability, however, water-in-oil emulsions have only been scarcely investigated. Margarine, a widely consumed water-in-oil emulsion, consists of
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Investigating the Thioredoxin and Glutathione Systems’ Response in Lymphoma Cells after Treatment with [Au(d2pype)2]CL Antioxidants (IF 5.014) Pub Date : 2021-01-13 Sicong Wang; Yaoying Lu; Kyra Woods; Giovanna Di Trapani; Kathryn F. Tonissen
Lymphoma is a blood cancer comprising various subtypes. Although effective therapies are available, some patients fail to respond to treatment and can suffer from side effects. Antioxidant systems, especially the thioredoxin (Trx) and glutathione (GSH) systems, are known to enhance cancer cell survival, with thioredoxin reductase (TrxR) recently reported as a potential anticancer target. Since the
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High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells Antioxidants (IF 5.014) Pub Date : 2021-01-13 MaríaTeresa Donato; Laia Tolosa
Drug-induced liver injury (DILI) remains a major cause of drug development failure, post-marketing warnings and restriction of use. An improved understanding of the mechanisms underlying DILI is required for better drug design and development. Enhanced reactive oxygen species (ROS) levels may cause a wide spectrum of oxidative damage, which has been described as a major mechanism implicated in DILI
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Proximity Ligation Assay Detection of Protein–DNA Interactions—Is There a Link between Heme Oxygenase-1 and G-quadruplexes? Antioxidants (IF 5.014) Pub Date : 2021-01-12 Wojciech Krzeptowski; Patryk Chudy; Grzegorz Sokołowski; Monika Żukowska; Anna Kusienicka; Agnieszka Seretny; Agata Kalita; Alicja Czmoczek; Jakub Gubała; Sonia Baran; Damian Klóska; Mateusz Jeż; Jacek Stępniewski; Krzysztof Szade; Agata Szade; Anna Grochot-Przęczek; Alicja Józkowicz; Witold N. Nowak
G-quadruplexes (G4) are stacked nucleic acid structures that are stabilized by heme. In cells, they affect DNA replication and gene transcription. They are unwound by several helicases but the composition of the repair complex and its heme sensitivity are unclear. We found that the accumulation of G-quadruplexes is affected by heme oxygenase-1 (Hmox1) expression, but in a cell-type-specific manner:
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CARD8 and IL1B Polymorphisms Influence MRI Brain Patterns in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia Antioxidants (IF 5.014) Pub Date : 2021-01-12 Katarina Esih; Katja Goričar; Zvonka Rener-Primec; Vita Dolžan; Aneta Soltirovska-Šalamon
Inflammation and oxidative stress are recognized as important contributors of brain injury in newborns due to a perinatal hypoxic-ischemic (HI) insult. Genetic variability in these pathways could influence the response to HI and the outcome of brain injury. The aim of our study was to evaluate the impact of common single-nucleotide polymorphisms in the genes involved in inflammation and response to
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Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre Antioxidants (IF 5.014) Pub Date : 2021-01-12 Beatriz Castejón-Vega; Maurizio Battino; José L. Quiles; Beatriz Bullon; Mario D. Cordero; Pedro Bullón
The Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disorder caused by mutations in the Cathepsin C (CTSC) gene, characterized by periodontitis and palmoplantar hyperkeratosis. The main inflammatory deficiencies include oxidative stress and autophagic dysfunction. Mitochondria are the main source of reactive oxygen species; their impaired function is related to skin diseases and periodontitis
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Oxidation of Sperm DNA and Male Infertility Antioxidants (IF 5.014) Pub Date : 2021-01-12 Leila Rashki Ghaleno; AliReza Alizadeh; Joël R. Drevet; Abdolhossein Shahverdi; Mojtaba Rezazadeh Valojerdi
One important reason for male infertility is oxidative stress and its destructive effects on sperm structures and functions. The particular composition of the sperm membrane, rich in polyunsaturated fatty acids, and the easy access of sperm DNA to oxidative damage due to sperm cell specific cytologic and metabolic features (no cytoplasm left and cells unable to mount stress responses) make it the cell
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Mitochondrial Functionality in Male Fertility: From Spermatogenesis to Fertilization Antioxidants (IF 5.014) Pub Date : 2021-01-12 Yoo-Jin Park; Myung-Geol Pang
Mitochondria are structurally and functionally distinct organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to spermatozoa. They can also produce reactive oxidation species (ROS). While a moderate concentration of ROS is critical for tyrosine phosphorylation in cholesterol efflux, sperm–egg interaction, and fertilization, excessive ROS
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Ethyl Acetate Fraction of Helianthus tuberosus L. Induces Anti-Diabetic, and Wound-Healing Activities in Insulin-Resistant Human Liver Cancer and Mouse Fibroblast Cells Antioxidants (IF 5.014) Pub Date : 2021-01-12 Arokia Vijaya Anand Mariadoss; SeonJu Park; Kandasamy Saravanakumar; Anbazhagan Sathiyaseelan; Myeong-Hyeon Wang
Traditional, complementary, and integrative medicine are globally accepted alternative methods for the treatment of diabetes mellitus (DM). However, the mechanism of anti-diabetic effects of Helianthus tuberosus L. remains unproven. In the present study, antioxidant and anti-diabetic activity of the tubers of H. tuberosus were studied in detail. Methanolic extracts of H. tuberosus tubers were subjected
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Visceral Adipose Tissue of Prediabetic and Diabetic Females Shares a Set of Similarly Upregulated microRNAs Functionally Annotated to Inflammation, Oxidative Stress and Insulin Signaling Antioxidants (IF 5.014) Pub Date : 2021-01-12 Justyna Strycharz; Adam Wróblewski; Andrzej Zieleniak; Ewa Świderska; Tomasz Matyjas; Monika Rucińska; Lech Pomorski; Piotr Czarny; Janusz Szemraj; Józef Drzewoski; Agnieszka Śliwińska
Hypertrophic and hypoxic visceral adipose tissue (VAT) secretes proinflammatory cytokines promoting insulin resistance (IR), prediabetes and type 2 diabetes (T2DM) microRNAs (miRNAs) are markers of metabolic disorders regulating genes critical for e.g., inflammation, glucose metabolism, and antioxidant defense, with raising diagnostic value. The aim of the current study was to evaluate whether hyperglycemia
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Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death Antioxidants (IF 5.014) Pub Date : 2021-01-12 Hyun Joo Shin; Eun Ae Jeong; Jong Youl Lee; Hyeong Seok An; Hye Min Jang; Yu Jeong Ahn; Jaewoong Lee; Kyung Eun Kim; Gu Seob Roh
The hippocampal cell death that follows kainic acid (KA)-induced seizures is associated with blood–brain barrier (BBB) leakage and oxidative stress. Lipocalin-2 (LCN2) is an iron-trafficking protein which contributes to both oxidative stress and inflammation. However, LCN2’s role in KA-induced hippocampal cell death is not clear. Here, we examine the effect of blocking LCN2 genetically on neuroinflammation
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Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress Antioxidants (IF 5.014) Pub Date : 2021-01-12 Federico Pietrocola; José Manuel Bravo-San Pedro
Reactive oxygen species (ROS) operate as key regulators of cellular homeostasis within a physiological range of concentrations, yet they turn into cytotoxic entities when their levels exceed a threshold limit. Accordingly, ROS are an important etiological cue for obesity, which in turn represents a major risk factor for multiple diseases, including diabetes, cardiovascular disorders, non-alcoholic
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Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review Antioxidants (IF 5.014) Pub Date : 2021-01-12 Paula Fernández-Palanca; Carolina Méndez-Blanco; Flavia Fondevila; María J. Tuñón; Russel J. Reiter; José L. Mauriz; Javier González-Gallego
Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine with antioxidant, chronobiotic and anti-inflammatory properties; reduced levels of this hormone are associated with higher risk of cancer. Several beneficial effects of melatonin have been described in a broad number of tumors, including liver cancers. In this work we systematically reviewed the publications of the last 15 years that assessed
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Nuclear Localization of Heme Oxygenase-1 in Pathophysiological Conditions: Does It Explain the Dual Role in Cancer? Antioxidants (IF 5.014) Pub Date : 2021-01-11 Marilina Mascaró; Eliana N. Alonso; Exequiel G. Alonso; Ezequiel Lacunza; Alejandro C. Curino; María Marta Facchinetti
Heme Oxygenase-1 (HO-1) is a type II detoxifying enzyme that catalyzes the rate-limiting step in heme degradation leading to the formation of equimolar quantities of carbon monoxide (CO), free iron and biliverdin. HO-1 was originally shown to localize at the smooth endoplasmic reticulum membrane (sER), although increasing evidence demonstrates that the protein translocates to other subcellular compartments
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The Time-Course of Antioxidant Irisin Activity: Role of the Nrf2/HO-1/HMGB1 Axis Antioxidants (IF 5.014) Pub Date : 2021-01-11 Agnieszka Irena Mazur-Bialy; Ewa Pocheć
The production of free radicals is one of the basic mechanisms giving rise to the antimicrobial activity of macrophages; however, excessive accumulation of reactive oxygen species (ROS) can lead to cell damage, cell death, and release of the highly proinflammatory alarmin high-mobility group box 1 (HMGB1). This study aimed to evaluate the kinetics of antioxidant properties of the adipomyokine irisin
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Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins Antioxidants (IF 5.014) Pub Date : 2021-01-11 Ana Álvarez-Barrios; Lydia Álvarez; Montserrat García; Enol Artime; Rosario Pereiro; Héctor González-Iglesias
The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye
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Enhanced Oral Bioavailability of Resveratrol by Using Neutralized Eudragit E Solid Dispersion Prepared via Spray Drying Antioxidants (IF 5.014) Pub Date : 2021-01-11 Eun-Sol Ha; Du Hyung Choi; In-hwan Baek; Heejun Park; Min-Soo Kim
In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol. Solid-state characterization of amorphous solid dispersions of trans-resveratrol was performed using powder X-ray diffraction, scanning electron microscopy, and particle size measurements. In addition, an in vitro dissolution
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The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function Antioxidants (IF 5.014) Pub Date : 2021-01-11 Gemma Fabozzi; Benedetta Iussig; Danilo Cimadomo; Alberto Vaiarelli; Roberta Maggiulli; Nicolò Ubaldi; Filippo Maria Ubaldi; Laura Rienzi
Accumulating evidence on the effect of nutrition on reproduction is emerging from both animal and human studies. A healthy dietary pattern and nutrient supplementation, especially during the peri-conceptional period, might be helpful to achieve a live birth, although the mechanisms implicated are not fully understood. The endocrine system and the ooplasmic organelles apparatus, in particular the mitochondria
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Mitochondrial Reactive Oxygen Species (ROS) Production Alters Sperm Quality Antioxidants (IF 5.014) Pub Date : 2021-01-11 Rosanna Chianese; Riccardo Pierantoni
Besides ATP production, mitochondria are key organelles in several cellular functions, such as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the generation of reactive oxygen species (ROS). Despite the loss of the majority of the cytoplasm occurring during spermiogenesis, mammalian sperm preserves a number of mitochondria that rearrange in a tubular structure
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Association of Metabolically Healthy and Unhealthy Obesity Phenotypes with Oxidative Stress Parameters and Telomere Length in Healthy Young Adult Men. Analysis of the MAGNETIC Study Antioxidants (IF 5.014) Pub Date : 2021-01-11 Mateusz Lejawa; Kamila Osadnik; Tadeusz Osadnik; Natalia Pawlas
Obesity is a significant factor related to metabolic disturbances that can lead to metabolic syndrome (MetS). Metabolic dysregulation causes oxidative stress, which affects telomere structure. The current study aimed to evaluate the relationships between telomere length, oxidative stress and the metabolically healthy and unhealthy phenotypes in healthy young men. Ninety-eight participants were included
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Role of Exendin-4 in Brain Insulin Resistance, Mitochondrial Function, and Neurite Outgrowth in Neurons under Palmitic Acid-Induced Oxidative Stress Antioxidants (IF 5.014) Pub Date : 2021-01-09 Danbi Jo; Gwangho Yoon; Juhyun Song
Glucagon like peptide 1 (GLP-1) is an incretin hormone produced by the gut and brain, and is currently being used as a therapeutic drug for type 2 diabetes and obesity, suggesting that it regulates abnormal appetite patterns, and ameliorates impaired glucose metabolism. Many researchers have demonstrated that GLP-1 agonists and GLP-1 receptor agonists exert neuroprotective effects against brain damage
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Changes in Urinary Biomarkers of Organ Damage, Inflammation, Oxidative Stress, and Bone Turnover Following a 3000-m Time Trial Antioxidants (IF 5.014) Pub Date : 2021-01-09 Takaki Tominaga; Sihui Ma; Kaoru Sugama; Kazue Kanda; Chiaki Omae; Wonjun Choi; Shunsuke Hashimoto; Katsuhiko Aoyama; Yasunobu Yoshikai; Katsuhiko Suzuki
Strenuous exercise induces organ damage, inflammation, and oxidative stress. Currently, to monitor or investigate physiological conditions, blood biomarkers are frequently used. However, blood sampling is perceived to be an invasive method and may induce stress. Therefore, it is necessary to establish a non-invasive assessment method that reflects physiological conditions. In the present study, we
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Quercetin and Egg Metallome Antioxidants (IF 5.014) Pub Date : 2021-01-09 Evangelos Zoidis; Athanasios C. Pappas; Michael Goliomytis; Panagiotis E. Simitzis; Kyriaki Sotirakoglou; Savvina Tavrizelou; George Danezis; Constantinos A. Georgiou
The objective of the present study was to investigate the effect of the natural flavonoid quercetin dietary supplementation on the alteration of egg metallome by applying the basic principles of elemental metabolomics. One hundred and ninety-two laying hens were allocated into 4 treatment groups: the control (C) group that was fed with a commercial basal diet and the other experimental groups that
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Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug Discovery Antioxidants (IF 5.014) Pub Date : 2021-01-09 Jinjoo Lee; Seungjin Noh; Suhyun Lim; Bonglee Kim
Type 2 diabetes mellitus (T2DM) is one of the largest public health problems worldwide. Insulin resistance-related metabolic dysfunction and chronic hyperglycemia result in devastating complications and poor prognosis. Even though there are many conventional drugs such as metformin (MET), Thiazolidinediones (TZDs), sulfonylureas (SUF), dipeptidyl peptidase 4 (DPP-4) inhibitors, glucagon like peptide
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Involvement of RAGE and Oxidative Stress in Inflammatory and Infectious Skin Diseases Antioxidants (IF 5.014) Pub Date : 2021-01-09 Fabrizio Guarneri; Paolo Custurone; Valeria Papaianni; Sebastiano Gangemi
The surface receptor for advanced glycosylation end-products (RAGE) and its soluble (sRAGE) and endogenous secretory (EN-RAGE) forms belong to the superfamily of toll-like receptors and play important roles in inflammation and autoimmunity, directly or through binding with advanced glycosylation end-products (AGE) and advanced oxidation protein products (AOPP). We reviewed the literature on the role
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Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer Antioxidants (IF 5.014) Pub Date : 2021-01-09 Shreyas Gaikwad; Sanjay K. Srivastava
Over the past few decades, research on reactive oxygen species (ROS) has revealed their critical role in the initiation and progression of cancer by virtue of various transcription factors. At certain threshold values, ROS act as signaling molecules leading to activation of oncogenic pathways. However, if perturbated beyond the threshold values, ROS act in an anti-tumor manner leading to cellular death
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Sirtuins—The New Important Players in Women’s Gynecological Health Antioxidants (IF 5.014) Pub Date : 2021-01-10 Ewa Maria Kratz; Izabela Kokot; Violetta Dymicka-Piekarska; Agnieszka Piwowar
The participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma has been indicated as of primary importance. Despite many existing studies, research on sirtuins continues to present an opportunity to discover new
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Rutaecarpine Protects against Acetaminophen-Induced Acute Liver Injury in Mice by Activating Antioxidant Enzymes Antioxidants (IF 5.014) Pub Date : 2021-01-10 Jae Ho Choi; Sun Woo Jin; Gi Ho Lee; Eun Hee Han; Yong Pil Hwang; Hye Gwang Jeong
Rutaecarpine, an indolopyridoquinazolinone alkaloid isolated from the unripe fruit of Evodia rutaecarpa, is used to treat hypertension, postpartum hemorrhage, dysentery, and amenorrhea as a traditional medicine in Asia. We investigated the effect of rutaecarpine on acetaminophen-induced hepatotoxicity in mice. Rutaecarpine was administered orally daily for seven consecutive days, followed by intraperitoneal
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Proniosomal Gel for Topical Delivery of Rutin: Preparation, Physicochemical Characterization and In Vitro Toxicological Profile Using 3D Reconstructed Human Epidermis Tissue and 2D Cells Antioxidants (IF 5.014) Pub Date : 2021-01-10 Iulia Pinzaru; Alina Tanase; Virgil Enatescu; Dorina Coricovac; Flavia Bociort; Iasmina Marcovici; Claudia Watz; Lavinia Vlaia; Codruta Soica; Cristina Dehelean
Rutin (Rut) is a natural flavonol, well-known for its broad-spectrum of therapeutic effects, including antioxidant and antitumoral activities; still, it has a reduced clinical outcome due to its limited solubility in aqueous solutions. To overcome this drawback, this study proposes a novel formulation for rutin as a proniosomal gel for cutaneous applications. The gel was prepared by coacervation phase-separation
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The Effect of Foliar Selenium (Se) Treatment on Growth, Photosynthesis, and Oxidative-Nitrosative Signalling of Stevia rebaudiana Leaves Antioxidants (IF 5.014) Pub Date : 2021-01-08 Péter Borbély; Árpád Molnár; Emil Valyon; Attila Ördög; Klára Horváth-Boros; Dezső Csupor; Attila Fehér; Zsuzsanna Kolbert
Selenium (Se) enrichment of Stevia rebaudiana Bertoni can serve a dual purpose, on the one hand to increase plant biomass and stress tolerance and on the other hand to produce Se fortified plant-based food. Foliar Se spraying (0, 6, 8, 10 mg/L selenate, 14 days) of Stevia plantlets resulted in slightly decreased stevioside and rebaudioside A concentrations, and it also caused significant increment
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Pharmacological and Antioxidant Activities of Rhus coriaria L. (Sumac) Antioxidants (IF 5.014) Pub Date : 2021-01-08 Halima Alsamri; Khawlah Athamneh; Gianfranco Pintus; Ali H. Eid; Rabah Iratni
Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, ulcer, and eye inflammation. This plant is rich in various classes
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Evaluation of Cysteine Metabolism in the Rat Liver and Kidney Following Intravenous Cocaine Administration and Abstinence Antioxidants (IF 5.014) Pub Date : 2021-01-08 Danuta Kowalczyk-Pachel; Małgorzata Iciek; Anna Bilska-Wilkosz; Magdalena Górny; Joanna Jastrzębska; Kinga Kamińska; Paulina Dudzik; Małgorzata Filip; Elżbieta Lorenc-Koci
Many toxic effects of cocaine are attributed to reactive oxygen species (ROS) generated during its metabolism. Recently, it has been suggested that the biological action of ROS is often confused with endogenously generated reactive sulfur species (RSS). The aim of this study was to evaluate the impact of cocaine on thiols and RSS in the rat liver and kidney in the drug self-administration (SA) paradigm
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Counteracting Effects of Glutathione on the Glutamate-Driven Excitation/Inhibition Imbalance in First-Episode Schizophrenia: A 7T MRS and Dynamic Causal Modeling Study Antioxidants (IF 5.014) Pub Date : 2021-01-08 Roberto Limongi; Peter Jeon; Jean Théberge; Lena Palaniyappan
Oxidative stress plays a key role in the pathophysiology of schizophrenia. While free radicals produced by glutamatergic excess and oxidative metabolism have damaging effects on brain tissue, antioxidants such as glutathione (GSH) counteract these effects. The interaction between glutamate (GLU) and GSH is centered on N-Methyl-D-aspartate (NMDA) receptors. GSH levels increase during glutamate-mediated
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Hydrogen-Generating Silica Material Prevents UVA-ray-Induced Cellular Oxidative Stress, Cell Death, Collagen Loss and Melanogenesis in Human Cells and 3D Skin Equivalents Antioxidants (IF 5.014) Pub Date : 2021-01-08 Li Xiao; Mai Mochizuki; Taka Nakahara; Nobuhiko Miwa
Ultraviolet-A (UVA) irradiation induces harmful effects on skin cells and accelerates skin aging through oxidative stress. In this study, the effects of a hydrogen-generating silica material named ULH-002 against UVA injuries in human cells and 3D skin equivalents were investigated. The oxygen radical absorption capacity (ORAC) assay showed that both freshly prepared ULH-002 solutions and 7-day-old
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Total Antioxidant Capacity in HBV Carriers, a Promising Biomarker for Evaluating Hepatic Fibrosis: A Pilot Study Antioxidants (IF 5.014) Pub Date : 2021-01-08 Jing-Hua Wang; Sung-Bae Lee; Dong-Soo Lee; Chang-Gue Son
Oxidative stress plays a pivotal role in the progression of chronic hepatitis B; however, it is unclear whether the status of blood oxidative stress and antioxidant components differs depending on the degree of hepatic fibrosis. To explore the relationship between oxidative stress/antioxidant capacity and the extent of hepatic fibrosis, fifty-four subjects with liver fibrosis (5.5 ≤ liver stiffness
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Oxidative Stress in the Pathogenesis of Crohn’s Disease and the Interconnection with Immunological Response, Microbiota, External Environmental Factors, and Epigenetics Antioxidants (IF 5.014) Pub Date : 2021-01-07 Ester Alemany-Cosme; Esteban Sáez-González; Inés Moret; Beatriz Mateos; Marisa Iborra; Pilar Nos; Juan Sandoval; Belén Beltrán
Inflammatory bowel disease (IBD) is a complex multifactorial disorder in which external and environmental factors have a large influence on its onset and development, especially in genetically susceptible individuals. Crohn’s disease (CD), one of the two types of IBD, is characterized by transmural inflammation, which is most frequently located in the region of the terminal ileum. Oxidative stress
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Arabidopsis APx-R Is a Plastidial Ascorbate-Independent Peroxidase Regulated by Photomorphogenesis Antioxidants (IF 5.014) Pub Date : 2021-01-07 Fernanda Lazzarotto; Khadija Wahni; Maiara Piovesana; Felipe Maraschin; Joris Messens; Marcia Margis-Pinheiro
Peroxidases are enzymes that catalyze the reduction of hydrogen peroxide, thus minimizing cell injury and modulating signaling pathways as response to this reactive oxygen species. Using a phylogenetic approach, we previously identified a new peroxidase family composed of a small subset of ascorbate peroxidase (APx) homologs with distinguished features, which we named ascorbate peroxidase-related (APx-R)
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Water Soluble Iron-Based Coordination Trimers as Synergistic Adjuvants for Pancreatic Cancer Antioxidants (IF 5.014) Pub Date : 2021-01-07 Marco Cordani; Esther Resines-Urien; Arturo Gamonal; Paula Milán-Rois; Lionel Salmon; Azzedine Bousseksou; Jose Sanchez Costa; Álvaro Somoza
Pancreatic cancer is a usually fatal disease that needs innovative therapeutic approaches since the current treatments are poorly effective. In this study, based on cell lines, triazole-based coordination trimers made with soluble Fe(II) in an aqueous media were explored for the first time as adjuvant agents for the treatment of this condition. These coordination complexes were effective at relatively
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Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells Antioxidants (IF 5.014) Pub Date : 2021-01-07 Niina Bhattarai; Niina Piippo; Sofia Ranta-aho; Yashavanthi Mysore; Kai Kaarniranta; Anu Kauppinen
Age-related macular degeneration (AMD) is an eye disease in which retinal pigment epithelium (RPE) cells play a crucial role in maintaining retinal homeostasis and photoreceptors’ functionality. During disease progression, there is increased inflammation with nucleotide-binding domain, leucine-rich repeat, and Pyrin domain 3 (NLRP3) inflammasome activation, oxidative stress, and impaired autophagy
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Antioxidant Activity and Biocompatibility of Fructo-Polysaccharides Extracted from a Wild Species of Ornithogalum from Lebanon Antioxidants (IF 5.014) Pub Date : 2021-01-07 Mohammad Kazem Medlej; Cherri Batoul; Hamza Olleik; Suming Li; Akram Hijazi; Ghassan Nasser; Marc Maresca; Céline Pochat-Bohatier
The present study aims to investigate the properties of biopolymers extracted from a Lebanese onion non edible plant. The extraction was performed under mild conditions by varying the percentage of ultra-sound (US) treatment duration to a total extraction time of 30 min (0, 50, 100% US). The extracts were characterized using FTIR, SEC, GC-MS, TGA, and DSC analyses. The composition of the extracts was
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Hypoglycemic Effect of Resveratrol: A Systematic Review and Meta-Analysis Antioxidants (IF 5.014) Pub Date : 2021-01-07 Beatriz Isabel García-Martínez; Mirna Ruiz-Ramos; José Pedraza-Chaverri; Edelmiro Santiago-Osorio; Víctor Manuel Mendoza-Núñez
Resveratrol (RV) is a polyphenolic compound with antioxidant, anti-inflammatory, and hypoglycemic properties. Several in vitro and animal model studies have demonstrated the beneficial effects of RV; however, the results in humans are not conclusive. After a search of different databases, 32 studies were selected for this systematic review and 30 were included in the meta-analysis. Studies that evaluated
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UPLC-ESI-Q-TOF-MS-Based Metabolite Profiling, Antioxidant and Anti-Inflammatory Properties of Different Organ Extracts of Abeliophyllum distichum Antioxidants (IF 5.014) Pub Date : 2021-01-07 Tong-Kewn Yoo; Won Tae Jeong; Jun Gu Kim; Hyo Seong Ji; Min-A Ahn; Jong-Wook Chung; Heung Bin Lim; Tae Kyung Hyun
Plant extracts have gained more attention as natural therapeutic agents against inflammation characterized by an overproduction of several inflammatory mediators such as reactive oxygen species and pro-inflammatory cytokines. Although Abeliophyllum distichum Nakai is generally known for its ornamental value, recent pharmacological research has demonstrated its potential therapeutic properties. Thus
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Antioxidant Activity in Bee Products: A Review Antioxidants (IF 5.014) Pub Date : 2021-01-07 Marianna Martinello; Franco Mutinelli
Bee products have been used since ancient times both for their nutritional value and for a broad spectrum of therapeutic purposes. They are deemed to be a potential source of natural antioxidants that can counteract the effects of oxidative stress underlying the pathogenesis of many diseases. In view of the growing interest in using bioactive substances from natural sources to promote health and reduce
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Mapping the Primary and Secondary Metabolomes of Carob (Ceratonia siliqua L.) Fruit and Its Postharvest Antioxidant Potential at Critical Stages of Ripening Antioxidants (IF 5.014) Pub Date : 2021-01-05 Marios C. Kyriacou; Chrystalla Antoniou; Youssef Rouphael; Giulia Graziani; Angelos Kyratzis
Six critical stages corresponding to major morphophysiological events in carob fruit ripening were defined, and changes in the primary and secondary metabolome and in vitro antioxidant capacity were examined in two genotypes collected at low (15 m) and high (510 m) altitudes from genetically identified and georeferenced trees. Soluble carbohydrates were analyzed by HPLC-RI, macro-minerals by ion chromatography
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