Antibiotic-resistance and bacterial bioburden are the threats to wound healing. Nanoparticles are a revolutionary advancement in nanomedicine owing to their antibacterial properties, to be used as a promising alternative to antibiotics. A wound dressing with antibacterial and anti-biofilm effects may be a plausible strategy in curbing wound exacerbation caused by bacterial infection. Silver nanoparticles

Breast cancer is the most commonly diagnosed cancer among women worldwide. Surgical removal of tumors is often necessary and many patients suffer complications due to subsequent breast reconstruction. A safe and effective breast reconstructive material is needed for patients recovering from surgical removal of small breast cancer tumors. Our lab has developed injectable collagen/tannic acid beads seeded

To maintain the cellular functions of a stem cells for therapeutic tissue engineering, an advanced cell culture method for safe cell dissociation is necessary. We developed a novel cell dissociation method by applying pH-responsive bioreducible polymer on the surface of tissue culture plates (TCPs). We applied acid-responsive bioreducible poly (amino ester) (PAE) as a new candidate for surface coating

Dialyzed tilapia skin collagen sponge (DTSCS) and self-assembled tilapia skin collagen sponge (STSCS) were prepared by freeze-drying. The raw components used in the fabrication of DTSCS and STSCS were separated and purified from tilapia fish skin. It is anticipated that these collagen sponges could be developed into medical dressings for hemostasis and wound healing. The aim of the present research

Long-distance (⩾10 mm) arterial vascular defect injury was a massive challenge affecting human health. Compared with autologous transplantation, tissue-engineered scaffolds such as biocompatible silk fibroin (SF) scaffolds have been developed because they exhibit equivalent functional repair effects without adverse reactions. However, its mechanical strength and structural stability needed to be further

Karimi Hajishoreh N, Baheiraei N, Naderi N, Salehnia M. Reduced graphene oxide facilitates biocompatibility of alginate for cardiac repair. Journal of Bioactive and Compatible Polymers 2020; 35(4-5): 363–377. doi:10.1177/0883911520933913

Chronic exposure to UVB radiation causes photoaging, immunosuppression, and ultimately photocarcinogenisis through the generation of reactive oxygen species (ROS). The ability of natural compounds in neutralizing the effects of oxidative stress is being explored with increased interest. Silk sericin, a biopolymer is reported to have diverse biological properties. In an effort to make the silk sericin

The global health concern on wound care is becoming more challenging with the emerging prevalence of inexorable antibiotic resistance. Amidst this crisis, various material innovations have been made to combat this dilemma. Herein, squid pens, which are regarded as discards in the seafood industry, were biorefined into β-chitin-graft-polyaniline (β-chitin-g-PANI) composites for possible wound dressing

In the present study, we developed a novel niosomal nanocarrier embedded into a collagen/β- tricalcium phosphate (Col/β-TCP) scaffold for the local delivery of thymol as a natural anti-bacterial reagent. The niosomal Col/β-TCP (N-Col/β-TCP) scaffolds with different weight ratios of β-TCP to Col were prepared by freeze-drying. The antimicrobial activities of the prepared samples against Escherichia

For an effective medical application of therapeutic siRNA, a safe and an efficient delivery system are required. Herein, magnetic nanoparticles (MNPs) have been successfully used as siRNA delivery vehicles. Firstly, MNPs were coated with gold (Au) nanoparticles and then capped with PEI. To improve the biocompatibility of nanoparticles, hyaluronic acid (HA) was coated onto the surface of PEI-Au/Fe nanoparticles

In tissue engineering, natural hydrogel scaffolds gained considerable attention due to their biocompatibility and similarity to macromolecular-based components in the body. However, their low mechanical strength and high degradation degree limit their biomedical application. By varying the composition of hydrogels, their biochemical and mechanical properties can be improved. In this study, the stability

Dentine sensitivity is a dental problem common in individuals aged between 20 and 50 years. The most effective treatment method involves occluding the exposed dental tubules. This study focused on the synthesis of calcium phosphate nanoparticles in the form of gel to use as a proof of concept for home-treatment of sensitive teeth. In this study, calcium phosphate nanoparticles were prepared using emulsion

The objectives were to synthesize urethane grafted nano-apatite in shortest possible time duration using the microwave irradiation method and to utilize them for synthesis of experimental dental adhesives. The structural, morphological, thermal, and mechanical behavior of synthesized grafted nano-apatite were investigated. Then, these grafted nano-apatite particles were incorporated in various concentrations

Star-shaped polymers of biodegradable aliphatic polyester, poly(ε-caprolactone), PCL, with different number of arms (three, four, and six) were synthesized by ring-opening polymerization initiated by multifunctional alcohols used as cores. As potential biomaterials, synthesized star-shaped poly(ε-caprolactone)s, sPCL, were thoroughly characterized in terms of their degradation under different pH conditions

Zingerone loaded chitosan nanoparticles (Z-NPs) were developed to deliver the Zingerone across cell membrane and to further enhance its anti-virulence property. The Z-NPs were characterized with respect to size, percentage entrapment efficiency (% EE), zeta potential and percentage drug release. Further the Z-NPs were evaluated for antioxidant DPPH assay, antibiofilm, anti-virulence activities, and

A new biofilm of cellulose coated with hydroxyapatite particles have been prepared using a simple, fast and low temperature process based on a microwave-assisted hydrothermal synthesis. The cellulose used as matrix of the biocomposite was extracted from banana stems residues. The hydroxyapatite coating was performed using calcium nitrate tetrahydrate, phosphoric acid, and 1,2-ethylenediamine dispersed

The benefits of combined cell/material therapy appear promising for myocardial infarction treatment. The safety of alginate, along with its excellent biocompatibility and biodegradability, has been extensively investigated for cardiac tissue engineering. Among graphene-based nanomaterials, reduced graphene oxide has been considered as a promising candidate for cardiac treatment due to its unique physicochemical

A new emulsification-crosslinking method was developed for the preparation of chitosan microspheres. The new method uses an aqueous alkali–urea solution, instead of the commonly used acidic solvents, to dissolve chitosan. After emulsification, the water-in-oil droplets are solidified by heating, taking advantage of the unique in situ thermal gelling behavior of the alkaline chitosan solution, instead

In this study, a reproducible urethral injury animal model was developed and the role of the biodegradable drug-eluting urethral stent in limiting urethral stricture formation after urethral injury was evaluated. A total of 22 rabbits were used, and 20 rabbits were randomly chosen to develop urethral injury animal model. Bulbar urethral injury was made by a self-designed explosion device in the 20

This study includes the design of a chitosan membrane decorated with unsaturated fatty acid–based carrier system for cancer treatment and antibacterial application. For this, polystyrene-graft-polyoleic acid-graft-polyethylene glycol was prepared by free radical polymerization and characterized. Nanoparticles and caffeic acid–loaded nanoparticles were prepared by solvent evaporation technique and optimized

Nano silver/polyvinyl alcohol hydrogel nanocomposites have been prepared using gamma irradiation technique. Gamma irradiation serves as a crosslinking agent for the polyvinyl alcohol hydrogels and also acts as a reducing agent for reduction of Ag+ ions to zero valent Ag0 within the polyvinyl alcohol crosslinked network. The microstructural characteristics of the prepared composites were studied using

Curcumin is a natural substance extracted from Curcuma longa Linn with beneficial pharmaceutical properties such as anticancer activity against several cellular lines. However, it presents poor bioavailability due to its low solubility in aqueous media and chemical instability. In this research, curcumin was encapsulated in polymer micelles obtained by the self-assembly of a biodegradable poly (ethylene

Electrospinning was used to produce fibrous membranes, in single and multiple layers, from poly(ε-caprolactone), pullulan, and from mixtures of poly(ε-caprolactone) with potato modified starch and β-glucan. It was possible to obtain single-layer membranes from solutions of pullulan in water, poly(ε-caprolactone) in chloroform, and from mixtures of poly(ε-caprolactone)/β-glucan and poly(ε-caprolactone)/potato

There is a growing interest in new type of biocidal compounds with antibacterial properties against bacteria. In this study, new antibacterial synthetic materials bearing curcumin and cationic polymers were synthesized. In the synthesis stage, the methacrylate functional cationic monomer was synthesized via the Michael addition route by using 3-acryloxy-2-hydroxypropyl methacrylate and 3-amino pyridine

Transmembrane delivery of biomolecules through nanoparticles plays an important role in targeted therapy. Here, we designed a simple nanoparticle for the delivery of model peptide drug into primary osteoclast precursor cells (bone marrow macrophages) by thermosensitive and biodegradable diblock copolymer monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate). The model peptide drug was

Despite advances in wound treatment, wound-associated infections and delayed healing still remains an ‘unmet clinical need’. The present treatment modalities include topical application of ointments and perhaps it may better be substituted by phytochemical incorporated nanofibers which increases wound-healing efficiency and reduce risk of infections. Hence, the aim of this study was to synthesise Areca

The wound dressing can temporarily replace the skin and play a protective role in the process of wound healing, preventing wound infection and inflammation, and providing a favorable environment for wound healing. In this study, a mixture of collagen and chitosan was lyophilized to be the host material of the sponge. This sponge was soaked into 1-ethyl-(dimethylaminopropyl) carbodiimide/N-hydroxy sulfosuccinimide

Ulvans represent one of the most abundant marine-derived macromolecular sulfated polysaccharides accounting for numerous biological applications including in one of the fastest growing field of biomedical sciences. Tissue engineering based on biologically inspired and naturally derived polymers has been one of the prime focuses of regenerative medicine. The present investigation is intended to explore

Poly lactic-co-glycolic acid particles are biodegradable and biocompatible drug delivery systems that provide a controlled release of drugs in specific sites. These characteristics minimize the occurrence of side effects related to overdosing. To overcome the issues associated with the conservative treatment for wound healing, the objective of this work was to develop a poly lactic-co-glycolic acid

To construct a graphical neural network in vitro and explore the morphological effects of neural network structural changes on neurons, this study aimed to introduce a method for fabricating microfluidic array chips with different graphical structures based on 248-nm excimer laser one-step etching. Through the comparative analysis of the graphical neural network cultured on our microfluidic array chip

The nanocomposite hydrogels were prepared by dispersing of the nanopomegranate seed particles into poly(vinyl alcohol)/poly(acrylic acid) blend matrix in an aqueous medium by the solvent casting method. These hydrogels were characterized using scanning electron microscopy, Fourier transform infrared spectra, differential scanning calorimetry, and optical contact angle instruments. The nanopomegranate

Interest in novel delivery systems that improve the cytoprotective and antioxidant effects of natural drugs has been explored recently due to the increase in the incidence of chronic diseases in which oxidation mechanisms are involved. Curcumin is a phenolic compound recently shown to be clinically significant due to its anti-inflammatory, anticancer, and antioxidant properties. However, this molecule

In this study, we aimed at fabricating a novel porous physical construct from quince seed mucilage for translational medicine applications. To achieve this goal, quince seed mucilage was extracted, molded, and freeze-dried. After being freeze-dried, the molded constructs were chemically crosslinked with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide/N-hydroxysuccinimide to maintain the mechanical integrity

The desired scaffolds for neural tissue engineering need to have electrical conductivity. In this study, we doubly coated graphene oxide and polypyrrole on silk fibroin scaffolds ([email protected]) by a facile method to improve its electrical conductivity. The graphene oxide–polypyrrole double coating was distributed homogeneously on silk fibroin scaffolds. Compared with silk fibroin scaffolds, the

Today, an advanced wound dressing with the ability of blood clotting and antibacterial activity is the main subject of many studies to consider their necessity in modern society. In this study, it was aimed to present a novel scaffold with both abilities simultaneously. Poly(vinyl alcohol)/poly(lactic acid) nanofibrous scaffolds containing ceftriaxone antimicrobial agent (PVA-CTX/PLA) and tranexamic

The emergence of multiple drug delivery systems can solve the disadvantages of single-drug therapy, such as high dose and easy generation of drug resistance. Here, we designed a sialic acid–targeted dextran-mercaptopurine prodrug linked by carbonyl vinyl sulfide for coordinate ZnO quantum dots to achieve multiple drug delivery (doxorubicin, 5-fluorouracil, 6-mercaptopurine), which can be released under

This study was designed to synthesize poly(sodium acrylate-co-N-isopropylacrylamide) via aqueous free-radical polymerization using the 2,2′-azobisisobutyronitrile initiator system at 60°C. The structural characterization of the copolymer was determined by Fourier-transform infrared spectroscopy. The polymer was synthesized in two different ratios, namely, poly(NaAc-co-NIPA1:1) and poly(NaAc-co-NIPA2:1)

Periodontitis is a chronic inflammatory disease that causes gum tissue degeneration and alveolar bone and tooth loss. The aim of this study is to develop a multifunctional matrix for the treatment of periodontitis and enhancement of regeneration of the periodontal tissue. The matrix was prepared from vitamin E containing hydrogel made of alginate and gelatin, and doxycycline HCl containing methoxy

For the advancement of Class V restoratives, our goal was to evaluate the physicochemical and mechanical properties, antimicrobial functionality, and cytotoxic potential of novel antimicrobial copolymers. 5-Carboxy-N-(2-(methacryloyloxy)ethyl)-N,N-dimethylpentan-1-aminium bromide (AMadh1) and 10-carboxy-N-(2-(methacryloyloxy)ethyl)-N,N-dimethyldecan-1-aminium bromide (AMadh2) were incorporated into

This study was designed to improve the permeability of two drugs (finasteride and minoxidil) through the skin. Finasteride-loaded poly(lactic acid-co-glycolic acid) and minoxidil-loaded chitosan nanoparticles were prepared by nanoprecipitation and ionic gelation method, respectively, and subsequently incorporated into semisolid Carbopol 940 gel. These fabricated nanoparticles were characterized for

Water-soluble chitosan and wood pulp fiber–based nonwovens were produced using wet-laying technology, and their properties were investigated for the potential application for severe hemorrhage. The pores of the wood pulp nonwovens were completely covered as the concentration of chitosan was increased. A phosphate buffer solution uptake of 997% was attained in the nonwoven loaded with chitosan concentration

In this study, dexamethasone-loaded gelatin–starch scaffolds were fabricated by the freeze-drying technique under different cooling temperatures and polymeric compositions. The constructs were modified via [3-(2,3-epoxypropoxy)-propyl]-trimethoxysilane coupling agent in order to produce a bioactive network structure for bone tissue engineering applications. Herein, the synergistic effect of [3-(2,

A broad range of polymers have been utilized for the development of blood-contacting implantable medical devices; however, their rate of failure has raised the need for developing more hemocompatible biomaterial surfaces. In this study, a novel scaffold based on polycaprolactone incorporated with 10% and 15% (w/w) Tulbaghia violacea plant extracts were fabricated using electrospinning technique. The

Among various bone regenerative and repair methods, use of osteoinductive scaffold as bone grafts/substitute has gained wide importance worldwide. To develop such osteoinductive scaffold that is more natural and which spontaneously stimulates osteoblast formation without any differentiation media, we prepared electrospun poly ε-caprolactone scaffold which is further modified by means of layer-by-layer

To obtain an efficient drug and gene co-delivery hydrogel, methoxy polyethylene glycol was reacted with the caprolactone units to form the MPEG-PCL block copolymer through the polymerization reaction, which is amphiphilic and can load the hydrophobic drugs. Then, MPEG-PCL conjugated with a multi-generation poly(L-lysine) dendron to form the guest molecule MPEG-PCL-PLLD. After interacted with α-cyclodextrin

Millions of people suffer from different types of skin diseases worldwide. In the last decade, the development of nanocarriers has been the focus of the pharmaceutical and cosmetic industries to enhance the performance of their products, and to meet consumers’ demands. Several delivery systems have been developed to improve the efficiency and minimize possible side effects. In this study, retinyl palmitate

In this study, films of O-carboxymethyl chitosan with Mimosa tenuiflora extract were manufactured, characterized, and evaluated. In this work, both the synthesis of O-carboxymethyl chitosan and the extraction of the active ingredient of Mimosa tenuiflora extract from the cortex are described. First, the extract of Mimosa tenuiflora in water was obtained by precipitation with ethanol, filtering, and

Elastin like polypeptides (ELPs) are a class of naturally derived and non-immunogenic biomaterials that are widely used in drug delivery and tissue engineering. ELPs undergo temperature-mediated inverse phase transitioning, which allows them to be purified in a relatively simple manner from bacterial expression hosts. Being able to genetically encode ELPs allows for the incorporation of bioactive peptides

N -halamine-based interpenetrating polymer networks were developed as a simple and effective strategy in the preparation of antimicrobial polymers. An N-halamine monomer, N-chloro-2, 2, 6, 6-tetramethyl-4-piperidyl methacrylate, was incorporated into polyurethane in the presence of a cross-linker and an initiator. Post-polymerization of the monomers led to the formation of polyurethane/N-halamine

Formation of scar tissue may be reduced or prevented if wounds were locally treated with a combination of molecules tuned to the different healing phases, guiding tissue regeneration along a scar free path. To this end, drug delivery devices made of cellulose acetate phthalate and Pluronic F-127 were loaded with either quercetin or pirfenidone and plasticized with either triethyl citrate (TEC) or tributyl

The presence of a conductive component in bone scaffolds can be helpful in facilitating the intracellular electrical signaling among cells as well as improving bone healing when electromagnetic stimulation is applied. In this study, poly(3,4-ethylenedioxythiophene): poly(4-styrene sulfonate) as a biocompatible conductive polymer was incorporated into a hard tissue scaffold made of gelatin (Gel) and