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Hyperbranched polyglycidol grafted with rosin by a natural catalyst under ultrasound: Synthesis, characterization and antimicrobial activity J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2024-03-11 Amina Mostefai, Mahmoud Belalia, Amine Harrane, Djahira Hamed, Mohammed Amin Bezzekhami, Louiza Belkacemi
This study aimed to apply a novel green polymerization process to produce a new copolymer with potential antimicrobial activity for industrial application. The glycidol was polymerized into hyperbranched polyglycidol (HPG) polymer which in turn has been esterified with rosin to produce hyperbranched copoly(glycidol-Rosin) (HPGR), a new co-polymer. The process used Maghnite-H+, a montmorillonite silicate
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Drug-eluting nanofibrous wound dressings composed of polycaprolactone and gelatin augment diabetic wounds healing via reducing oxidative stress and inflammation: An in vitro and in vivo study J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2024-03-05 Shungui Liu, Ziqiu Chen
Diabetes is a prevalent medical condition that often leads to complications, including diabetic wounds that can have serious consequences such as infections, amputations, and death. In the current research, lodoxamide was loaded into electrospun polycaprolacton/gelatin scaffolds In order to improve wound healing in a rat model. Our developed dressings were characterized in vitro using various methods
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The enduring impact of a visionary scientist J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2024-03-04 Hamid Omidian
This study chronicles the seminal contributions of Dr. Raphael M. Ottenbrite, the late Founding Editor of the Journal of Bioactive and Compatible Polymers, to polymer science from the 1970s through 2016. Beginning with an exploration of the biological impacts of anionic polymers, Dr. Ottenbrite’s research evolved to include their applications in immunology and cancer therapy. The 1980s marked a pivotal
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Electrospun silk fibroin/SIS-dECM hierarchical scaffolds for cell growth J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2024-02-19 Lusi Chen, Yahao Ma, Longyou Xiao, Pengfei Xie, Jianghui Liu, Wanmei Li, Xiaoying Wang, Liumin He
Biomaterials play an important role in biomedical applications serving as scaffolds in tissue engineering and substrates for cell growth by providing structural supports. Signaling cues for cellular events can be also presented, including cell viability, adhesion, spreading, and function developments. In this study, we fabricated a hierarchical nanofibrous scaffold through electrospinning silk fibroin
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Cellulose acetate scaffold containing hydroxyapatite/graphene oxide nanocomposite by electrospinning for advanced regenerative therapies J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2024-02-16 Luan dos Santos Menezes, Daniel Navarro da Rocha, Renato Carajelescov Nonato, Ana Rosa Costa, Ana Rita Morales, Lourenço Correr-Sobrinho, Américo Bortolazzo Correr, José Guilherme Neves
The aim of this study was to synthesize and characterize Cellulose Acetate (CA) porous scaffolds using the electrospinning technique associated with Hydroxyapatite (HA) and different concentrations of graphene oxide (GO), for advanced regenerative therapies application. The scaffolds were categorized into four distinct groups based on their composition: (1) Pure CA scaffolds; (2) CAHA scaffolds; (3)
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Bioactivity of chitosan nanoparticles synthesized by a novel route towards Escherichia coli and Bacillus subtilis J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2024-02-16 Kanchan Parate, Pratibha Pandey
Chitosan nanoparticles (CSNP) with an average size of 25.67 nm were synthesized via a novel wet chemical route and characterized using scanning electron microscopy (SEM) and Fourier Transform Infrared (FTIR) spectroscopy. Comparative antibacterial assays of Chitosan NP suspensions prepared in water (at neutral pH) and in dilute acetic acid and chitosan gel prepared in dilute acetic acid/hydrochloric
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Evaluating the anti-neuropathic effects of naringin-loaded chitosan nanocarriers in a murine model of constriction injury J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2024-01-04 Maryam Safari, Sajad Fakhri, Hassan Maleki, Mohammad Hosein Farzaei
Peripheral neuropathies are associated with various detrimental complications, leading to life-debilitating disorders, including neuropathic pain. Hence, the current study aimed to incorporate naringin, a potential natural component, into chitosan nanoparticles (NPs) to ameliorate the complications resulting from chronic constriction injury (CCI) induced painful neuropathy. The prepared NPs had a particle
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Fabrication of poloxamer based besifloxacin thermosensitive in situ gelling nanoemulsions for ophthalmic delivery J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-04-24 Seyedeh Negin Kassaee, Amir Nili-Ahmadabadi, Mohammad Mehdi Mahboobian
The present study aimed to develop and investigate besifloxacin (BSF) in situ gel nanoemulsions (NEs) consisting of two hydrophilic polymers, that is, poloxamer 407 (P407) and poloxamer 188 (P188),...
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Fabrication, optimization and cytotoxicity assessment of Ganoderma lucidum Triterpenoid-loaded electrospun gelatin nanofiber membrane as potential skin patch J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-04-07 Fahimeh Nojoki, Ashrafalsadat Hatamian-Zarmi, Bahman Ebrahimi-Hosseinzadeh, Hale Alvandi, Khadijeh Khezri, Nafiseh Dabbaghi, Mohammad Mir-derikvand, Fariba Malekpour Galougahi
Ganoderma lucidum triterpenoids (GLT) have shown special anti-tumor effects, but due to low yields and their hydrophobic structure, they have not found much clinical application. Box Behnken Design...
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Electrospun bio-nano hybrid scaffold from collagen, Nigella sativa, and chitosan for skin tissue engineering application J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-03-30 Md Rubel Alam, Md Abdus Shahid, Shah Alimuzzaman, Md Mehedi Hasan, Md Enamul Hoque
The new sophisticated tissue engineering focused on producing nanocomposite with different morphologies for rapid tissue regeneration. In this case, utilizing nanotechnology with the incorporation ...
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Pluronic-phosphatidylcholine mixed polymeric nanomicellar formulation for curcumin drug bioavailability: Design, fabrication, characterization and in vitro bioinvestigations J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-03-17 Hemil S Patel, Anju Kunjadiya, Abbas Rahdar, Rakesh K Sharma
Curcumin (CUR), obtained from turmeric, has biological advantages, but low aqueous solubility restricts its pharmaceutical applications. In the present work, a mixed polymeric nanomicellar formulat...
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Encapsulation and antibacterial studies of goji berry and garlic extract in the biodegradable chitosan J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-03-14 Gülay Baysal, Hatice Sena Olcay, Çağatay Günneç
As known, the chitosan is a biodegradable biopolymer with antibacterial properties, therefore it is used in the fields of pharmacy, medical, wastewater treatment, biotechnology, cosmetics, textiles...
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Evaluation of triacetin on mechanical strength and free surface energy of PHBHHx: The prevention of intra-abdominal adhesion J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-03-13 Meryem Akkurt Yıldırım, Murat Demirbilek, Kadriye Kızılbey, Engin Kaplan, Nelisa Türkoğlu
Several polymers are used for the preparation of biomaterials as membranes and films for tissue engineering applications. The most common plasticizer is PEG to obtain polymer-based biomaterials. On...
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Development of a three-dimensional in vitro blood-brain barrier using the chitosan-alginate polyelectrolyte complex as the extracellular matrix J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-03-13 Ece Bayir
Polyelectrolyte complexes (PECs) consist of a spontaneous assembly of oppositely charged polysaccharides. PECs can be used to obtain a hydrogel tissue scaffold in tissue culture. In this study, it ...
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Natural rubber latex films with effective growth inhibition against S. aureus via surface conjugated gentamicin J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-03-06 Aswin Arakkal, Paramban Sirajunnisa, Gopalakrishnanchettiar Sivakamiammal Sailaja
Hospital-associated infections and related complications are of extreme concern in the healthcare sector since biofilms generated over material surfaces not only create turbulence in the healthcare...
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Fabrication and characterization of apigenin-loaded chitosan/gelatin membranes for bone tissue engineering applications J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-02-22 Azam Bozorgi, Mozafar Khazaei, Maryam Bozorgi, Zahra Jamalpoor
Fabricating degradable polymer-based membranes has attracted much attention for guided bone regeneration. Chitosan/gelatin (Cs/Gel) composites are among the most known scaffolds with structural sim...
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Current status of hemostatic agents, their mechanism of action, and future directions J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-02-22 Ritvesh Gupta, Sibanwita Mohanty, Devendra Verma
The bleeding problem might seem straightforward, but it involves a plethora of complex biochemical pathways and responses. Hemorrhage control remains one of the leading causes of “preventable death...
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Preparation and performance of bacterial cellulose-based enzyme-carrying composite hydrogels as wound healing material J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-02-07 Meiling Shao, Zhan Shi, Chi Zhang, Zhongyi Li, Bin Zhai
As a biosynthetic polymer, Bacterial cellulose (BC) has been largely used in biomedical and technological fields for the excellent biocompatibility and water holding capability. In this study, BC h...
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Physico-mechanical and ex vivo analysis of aloe-alginate hydrogels for cervical cancer treatment J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-02-07 Patrick N Charron, Irfan Tahir, Sierra McConnell, Danielle Sedler, Rachael A Floreani
A leading cancer diagnosis in women worldwide is cervical cancer, with current treatments all posing a risk of serious side effects. Less toxic, but effective treatments are sought after. Aloe vera...
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Chitosan–silver nanocomposites as a promising tool for controlling the bed bug: Cimex lectularius (Heteroptera: Cimicidae) J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2023-01-21 Marwa M Attia, Mahmoud A Khalf, Mahmoud Abou-Okada, Muhammad SM Shamseldean, Mai A Salem, Mohammad Nafi Solaiman Al-Sabi
This study evaluates the use of chitosan–silver nanocomposites (CSN) as an insecticide against the bed bug (Cimex lectularius). Adult bed bugs were collected from infested residential areas and ide...
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Synthesis of cross-linked polymer based on purified Sterculia foetida L. gum as a potential hemostatic agent J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-12-15 Xuan Tien Le, Thanh Danh Tong, Thanh Tung Le, Pham Nguyen Thuy Dung, Long Giang Bach
A method for purifying the polysaccharides from Sterculia foetida L. gum was developed. The effects of purifying conditions were also studied. Results have shown that the conditions of pH 0.5, temp...
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Fabrication and characterization of electrospun GelMA/PCL/CS nanofiber composites for wound dressing applications J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-12-07 Esra Pilavci, Musa Ayran, Dilay Ulubay, Elif Kaya, Gulgun Tinaz, Ozlem Bingol Ozakpinar, Aykut Sancakli, Oguzhan Gunduz
In the present study, the effect of different ratios of GelMA concentration has been exhibited for wound dressing implementation by the electrospinning method using a new polymer combination of Gel...
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Regeneration of sciatic nerve injury through nanofiber neural guidance channels containing collagen hydrogel and acetyl L carnitine: An in vitro and in vivo study J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-12-04 Gholamreza Savari Kouzehkonan, Negar Motakef Kazemi, Mahdi Adabi, Seyyedeh Elaheh Mosavi, Seyed Mahdi Rezayat Sorkhabadi
Unlike the central nervous system (CNS), peripheral nervous system (PNS) injuries are partially repairable. Nerve guidance channels (NGCs) have been shown to improve the level of nerve repair after...
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Biophysical and in vitro wound healing assessment of collagen peptides processed from fish skin waste J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-11-23 Manjushree HK, Prakruti P Acharya, Ganapati Bhat, Sunil S More, Aneesa Fasim
The present study was conducted to examine the bioactive and wound healing properties of collagen hydrolysate derived from Piaractus brachypomus (pacu) fish skin waste. Collagen type I (P coll.) yi...
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Anticancer potential of poly(2-aminobenzoic acid)-blend-Aloe vera against the human breast cancer cell line MDA-MB-231 J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-11-23 Julia Sebastian, Jhancy Mary Samuel
Breast cancer in women is amongst the most significant concerns from time immemorial in the field of oncology. This study proposes an anticancerous polymeric material based on an electroactive subs...
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Co-electrospun poly(vinyl alcohol)/poly(ɛ-caprolactone) nanofiber scaffolds containing coffee and Calendula officinalis extracts for wound healing applications J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-10-19 Mahtab Doostan, Maryam Doostan, Hassan Maleki, Reza Faridi Majidi, Fariba Bagheri, Hossein Ghanbari
Fabrication of a biocompatible nanofibrous dressing with the advantage of the inclusion of bioactive herbal extracts is a promising approach in skin tissue engineering and wound healing application...
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Green synthesis of chicory (Cichorium intybus L.) Chitosan nanoparticles and evaluation of their anti-fungal, anti-hemolytic, and anti-cancer activities J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-10-13 Muobarak Tuorkey, Yasser Khedr, Samar Aborhyem, Xiang Xue
Chicory (Cichorium intybus L.) is widely consumed as a food plant in many regions of the world and has been involved in traditional medicine due to its unique contents of phytochemicals. We aimed t...
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Effect of pH on salicylic acid-based poly(anhydride-ester): Implications for polymer degradation and controlled salicylic acid release J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-09-28 Sammy Gulrajani, Sabrina Snyder, Jason D. Hackenberg, Kathryn Uhrich
Salicylic acid (SA)-based poly(anhydride-esters) (SAPAEs) hydrolytically degrade to release SA in a controlled manner over extended time periods. While these polymers have been well investigated un...
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Virucidal properties of new multifunctional fibrous N-halamine-immobilized styrene-divinylbenzene copolymers J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-09-09 Bohdan Murashevych, Dmytro Stepanskyi, Volodymyr Toropin, Alla Mironenko, Hanna Maslak, Konstantin Burmistrov, Nataliia Teteriuk
Virucidal properties of N-chlorosulfonamides immobilized on fibrous styrene-divinylbenzene copolymers have been studied. Corresponding materials with different functional group structures and chlor...
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Upon a potential approach to regulate the targeting region of inhalable liposomes J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-09-09 Lei Shu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan
Liposomes for inhalation have high biosafety and can achieve slow and controlled delivery, which are especially suitable for the treatment of lung diseases and have a promising clinical application...
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Synthesis of novel chitosan Schiff base and its ZnO nanocomposite for removal of synthetic dye, antimicrobial, and cytotoxicity activity J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-09-04 Mostafa M Gaafar, Fathy M Eltaweel, Hamada A Fouda, Magdy Y Abdelaal
In this work, a novel chitosan Schiff base 4-(2-Hydroxyaniline)pent-3-en-2-one chitosan (2-HyA-CS) and its ZnO nanocomposite (2-HyA-CS/ZnO) were sensitized and characterized by appropriate methods;...
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Influence of gelatin modification on enzymatically-gellable pectin-gelatin hydrogel properties for soft tissue engineering applications J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-08-26 Asal Ebrahimzadeh, Elnaz Khanalizadeh, Shahla Khodabakhshaghdam, Davoud Kazemi, Ali Baradar Khoshfetrat
Injectable in situ-forming hydrogels appears to be a promising approach for tissue engineering applications. In this study, the effect of phenol moiety (Ph) addition to gelatin in enzymatically-gel...
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Study on properties of 3D-printed GelMA hydrogel scaffolds with different nHA contents J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-08-22 Yaocheng Wang, Chengxiong Lin
Biological 3D printing is a reliable technology for 3D printing bone repair scaffolds with simple operation, high efficiency, and relatively low cost. Gelatin methacryloyl (GelMA) hydrogels have at...
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Pullulan and Pluronic F-127 based in situ gel system for intranasal delivery: Development, in vitro and in vivo evaluation J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-07-07 Hitendra S Mahajan, Vikram D Jadhao, Sachin M Chandankar
The current work seeks to use Pullulan and Pluronic F-127 (PF-127), a new gel-forming material, for sildenafil citrate (SLC) intranasal delivery. The cold approach was used to develop an SLC-loaded...
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In vivo therapeutic evaluation of a cellulose acetate hydrogel cross linked with ethylenediaminetetraacetic-dianhydride containing propolis ethanolic-extract for treating burns J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-07-05 Moema de Alencar Hausen, Anna Maria Gouvea Melero, Jessica Asami, Lucas Martins Ferreira, Guilherme Borges Gomes da Silva, Mariana Cesar de Azeredo Bissoli, Vanessa Rigoni Marcato, Bruno Dias Nani, Pedro Luiz Rosalen, Severino Matias de Alencar, Vagner Roberto Botaro, Daniel Komatsu, André Senna, Eliana Aparecida de Rezende Duek
An increasing interest in regenerative medicine has been an approach with natural products used for assorted skin treatments. Propolis from Apis mellifera species of bees have shown high acceptance...
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Synthesis, characterization and evaluation of in vitro antimicrobial and anti-diabetic activity of berberine encapsulated in guar-acacia gum nanocomplexes J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-06-22 Jyoti Bakshi, Meenakshi Mehra, Sapna Grewal, Dinesh Dhingra, Santosh Kumari
In the present study, the anti-diabetic and antimicrobial properties of berberine were improved using non-ionic guar gum and ionic acacia gum as nanocarriers. Berberine loaded guar-acacia gum nanoc...
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Improvement of osteogenic properties using a 3D-printed graphene oxide/hyaluronic acid/chitosan composite scaffold J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-06-17 Lai Suo, Zhijun Xue, Puyu Wang, Hongshan Wu, Yao Chen, Jing Shen
Oral and maxillofacial tumors, trauma and infections are the main causes of jaw defects, whose clinical treatment is very complicated. With the development of biological tissue engineering, many bi...
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Wound healing and anti-inflammatory effects of Anethum graveolens extract loaded in PVA fibers: An in vitro and in vivo study J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-06-10 Linli Li, Fengjuan Wang
Anethum graveolens extract (AGE) is known for its anti-inflammatory, antioxidative, and antibacterial activities. As wound infection, hyperactivity of inflammatory responses, and high oxidative str...
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In situ forming gelatin: Cyclodextrin hydrogels prepared by “click chemistry” to improve the sustained release of hydrophobic drugs J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-06-07 Phuong Le Thi, Thi Yen Nhi Tran, Hung Cuong Luu, Dieu Linh Tran, Thai Thanh Hoang Thi, Dai Hai Nguyen
Injectable hydrogels offer a wide range of attractive benefits in drug delivery applications, such as non-invasive administration, easy drug incorporation and locally controlled release at the target sites. Herein, we designed a simple and efficient method to prepare injectable hydrogels composed of gelatin and cyclodextrin (CD) for high loading capacity of hydrophobic drugs. The hydrogels were formed
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In vitro and in vivo evaluation of porous alginate hydrogel containing retinoic acid for skin wound healing applications J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-06-07 Simin Nazarnezhad, Majid Salehi, Hadi Samadian, Arian Ehtermi, Nahid Kasaiyan, Hossein Khastar, Ghasem Abbaszadeh-Goudarzi, Nariman Rezaei Kolarijani, Hodays Yeganehfard, Heliya Ziaei
The current study’s main aim was to fabricate and evaluate alginate (Alg) hydrogel containing retinoic acid (RA) as wound healing materials. Different RA concentrations (2, 10, and 50% w/w) were incorporated into the hydrogel. The results showed that the prepared hydrogels had a porous structure with a pore size of 69.69 ± 22.1 µm for pure Alg hydrogel and 78.44 ± 27.8 µm for Alg/RA hydrogel. The swelling
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Galloylated proanthocyanidins in dentin matrix exhibit biocompatibility and induce differentiation in dental stem cells J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-05-17 Daniel Kulakowski, Rasika M Phansalkar, Ariene A Leme-Kraus, James B McAlpine, Shao-Nong Chen, Guido F Pauli, Sriram Ravindran, Ana K Bedran-Russo
Grape seed extract contains a complex mixture of proanthocyanidins (PACs), a class of plant biopolymers that can be used as a biomaterial to improve reparative and preventive dental therapies. Co-polymerization of PACs with type I collagen mechanically reinforces the dentin extracellular matrix. This study assessed the biocompatibility of PACs from grape seed extract on dental pulp stem cells (DPSCs)
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CMC-based hydrogels loaded with Hypericum perforatum nanoemulsion for potential wound dressing applications J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-05-17 Mina Moradi, Aboulfazl Barati, Sara Moradi, Mohammad Arjomandzadegan
Wound healing is a complicated process requiring appropriate environment to accelerate healing process. In the recent years, many wound dressings have been developed for treating various kinds of wounds. In this study, we aimed to develop a novel dressing with high ability of burn wound healing and minimum side effects. Carboxymethyl cellulose (CMC) based hydrogels containing Hypericum perforatum were
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Coating of silver nanoparticles on polyurethane film surface by green chemistry approach and investigation of antibacterial activity against S. epidermidis J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-05-15 Filiz Kara, Eda Ayse Aksoy, Serpil Aksoy, Nesrin Hasirci
Silver nanoparticles with potential antibacterial properties are included in biomaterials for the production of medical devices, which are used for diagnoses or treatment purposes. The aim of the current study was coating the polyurethane (PU) films with silver nanoparticles (AgNPs) due to their antibacterial efficacy. PU films were first modified by chitosan (CH), treated with AgNO3 to let CH chelate
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Delivery of miRNA-126 through folic acid-targeted biocompatible polymeric nanoparticles for effective lung cancer therapy J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-05-12 Forough N Golafzani, Ali Z Vaziri, Masoud Javanmardi, Fatemeh Seyfan, Mahboubeh Yazdanifar, Sepideh Khaleghi
Objective: Nanoparticle-based drug delivery systems (DDSs) have been playing a considerable role in the eradication of cancer. In this experimental study, we designed and synthesized folic acid (FA)-decorated chitosan (CS) nanocarrier for targeted delivery of miR-126 (as a therapeutic agent) to lung cancer A549 cells. Materials and methods: Therefore, the FA-CS-miR-126 nano-complex was perfectly developed
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Antheraea pernyi silk fibroin-coated adenovirus as a VEGF165-Ang-1 dual gene delivery vector J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-04-27 Linling Huang, Yi Jiang, Xueping Liu, Ying Guo, Yanfei Feng, Peng Pan, Mingzhong Li, Yu Liu
Vascularization is a key challenge in the regeneration of tissues containing blood vessels. In this study, spermine was used for cationic modification of Antheraea pernyi silk fibroin (ASF) to synthesize cationized ASF (CASF). CASF/Ad complexes prepared by coating adenovirus (Ad) with CASF were used as delivery vectors for vascular endothelial growth factor 165 and angiopoietin-1 dual genes. The results
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Bi-layered PLGA electrospun membrane with occlusive and osteogenic properties for periodontal regeneration J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-04-27 Meiling Zhong, Jixia Lin, Zhimin He, Wuchao Wu, Dehui Ji, Richao Zhang, Jiali Zhang
Guided tissue regeneration (GTR) membranes not only can hamper undesirable tissues down-growth into the defects but also can selectively promote the in-growth of regenerative bone tissue, playing a critical role in periodontal regeneration. Herein, a bi-layered electrospun membrane with different sized pores was designed and fabricated by adjusting electrospinning parameters combing with facile two-step
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Methods for crosslinking and stabilization of chitosan structures for potential medical applications J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-03-14 Anna Woźniak, Monika Biernat
Chitosan is a well-known polymer widely used in tissue engineering and regenerative medicine. It is biocompatible, biodegradable, non-toxic, has antibacterial and osteoconductive properties. Chitosan is often used in the form of composites (with the participation of ceramic particles), membranes, hydrogels or nanoparticles. The problem with biomaterials is their low durability, rapid degradation, poor
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Synthesis and in vitro evaluation of natural drug loaded polymeric films for cardiovascular applications J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-03-12 Bakhtawar Ghafoor, Murtaza Najabat Ali
Drug eluting stents (DES) can efficiently reduce the atherosclerosis and restenosis issues of coronary artery as compared to bare metal stents due to the presence of pharmaceutically active agent on their surface. Nevertheless, the arising safety concerns of DES such as delayed healing and late in stent restenosis and thrombus, has stirred the research efforts to improve the outcomes of the DES. In
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Peripheral nerve regeneration by thiolated chitosan hydrogel containing Taurine: In vitro and in vivo study J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-03-12 Arian Ehtermi, Nariman Rezaei kolarijani, Simin Nazarnezhad, Morteza Alizadeh, Alireza Masoudi, Majid Salehi
About 2.8% of trauma sick persons hurt from peripheral nerve damages, thus, numerous approaches are using to improve peripheral nerve regeneration. In the current study, the efficacy of several dosages of Taurine for peripheral nerve regeneration was evaluated. About 0.1%, 1%, and 10% (w/w) of Taurine were added into thiolated chitosan hydrogel and its features including morphology, swelling properties
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Production of alginate films containing Hypericum perforatum extract as an antibacterial and antioxidant wound dressing material J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-02-08 Betül Mutlu, Fatih Erci, Rabia Çakir Koç
The incorporation of herbal extracts in wound dressing materials is an important concept that has been researched recently. In this study, alginate films incorporated in the various ratio (0.25–1% v/v) of Hypericum perforatum extract (HPE) for potential applications of wound dressing were successfully prepared by solvent-casting method. The obtained films were examined for cytotoxicity, in vitro wound
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Porous polysaccharide scaffolds: Proof of concept study on wound healing and stem cell differentiation J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-02-01 Preethi Gopalakrishnan Usha, Sreekutty Jalajakumari, Unnikrishnan Babukuttan Sheela, Deepa Mohan, Archana Meena Gopalakrishnan, Maya Sreeranganathan, Raveendran Kuttan Pillai, Catherine Berry, Kaustabh Kumar Maiti, Sreelekha Therakathinal Thankappan
The combination of desirable polymer properties and methods for synthesis, utilizing materials with various architectures, could be adopted for diverse clinical applications such as wound healing as well as stem cell differentiation. Natural polymers, particularly polysaccharides, are biocompatible and are reported to have structural similarities with extracellular matrix components. In this scenario
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Exploring polymeric biomaterials in developing neural prostheses J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2022-02-01 Thayvee Geetha Bharathi Silvaragi, Sevakumaran Vigneswari, Vikneswaran Murugaiyah, Amirul Al-Ashraf, Seeram Ramakrishna
Neuroprosthetics, with a range of applications such as cognitive, auditory, pain relief, recording, motor, and visual prosthetics have emerged as a promising field in recent years. However, poor electrical conductivity, a high disparity between tissue and interfaces and the onset of reactive gliosis post-implantation remains major challenges in the development of neuroprostheses. The choice of biomaterials
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A sunscreen nanoparticles polymer based on prolonged period of protection J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2021-12-17 Ebtesam A Mohamad, Monira M Rageh, Mirhan Mostafa Darwish
UV rays are one of the most dangerous factors that harm the skin. There is continuous improvement in getting an effective sunscreen that protects the skin from excessive exposure to UV rays. Typically, phenylbenzimidazole-5-sulfonic acid (PBSA) is used as a sun blocking agent, but its disadvantage is that it can photodegrade and cause cell damage. In our work, PBSA was encapsulated in niosomes nanoparticles
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A study of the electrophoretic deposition of polycaprolactone-chitosan-bioglass nanocomposite coating on stainless steel (316L) substrates J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2021-12-09 Zahra Sadeghinia, Rahmatollah Emadi, Fatemeh Shamoradi
In this research, bioglass nanoparticles were synthesized via sol-gel method and a polycaprolactone-chitosan-bioglass nanocomposite coating was formed on SS316L substrate using electrophoretic deposition method. Then, the effects of voltage and deposition time on morphology, thickness, roughness, and wettability of final coating were investigated. Finally, biocompatibility and toxicity of the coating
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Cell proliferative properties of Forcespinning® nopal composite nanofibers J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2021-11-23 Cristobal Rodriguez, Victoria Padilla, Karen Lozano, Fariha Ahmad, Alejandra Chapa, Alexa Villarreal, Andrew McDonald, Luis Materon, Robert Gilkerson
In this study, Forcespinning® was used to produce nanofibers composed of Opuntia cochenillifera, “nopal,” mucilage (N) extract, chitosan (CH), and pullulan (PL) (N/CH/PL). These nopal-incorporating nanofibers were examined for their ability to sustain adhesion and proliferation of mouse embryonic fibroblast (NIH 3T3) cells. After a 6-day incubation period, N/CH/PL nanofibers displayed robust cell proliferation
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Accelerating skin barrier repair using novel bioactive magnesium-doped nanofibers of non-mulberry silk fibroin during wound healing J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2021-11-23 Sharda Gupta, Pallab Dutta, Veena Acharya, Pushpa Prasad, Amit Roy, Arindam Bit
Novel magnesium doped non-mulberry silk fibroin nanofibers with ability to enhance skin barrier function were successfully fabricated using electrospinning technique for wound healing applications. Magnesium nanoparticles incorporated in the electrospun nanofibers releases Mg2+ ions at the site of implementation. The effect of Mg2+ is of considerable concern in wound healing due to its skin barrier
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Preparation of liposomal nanocarrier by extruder to enhance tumor accumulation of paclitaxel J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2021-11-05 Ngoc Thuy Trang Le, Ngoc Hoi Nguyen, Minh Chau Hoang, Cuu Khoa Nguyen, Dai Hai Nguyen, Dieu Linh Tran
Despite the wide-spectrum and effective anti-cancer activity of paclitaxel (PTX), their low solubility and side effects are the main challenges in their clinical application. In this study, a model paclitaxel-encapsulated nanoliposome (NLips-PTX) carrier was synthesized to enhance PTX solubility and increase its passive accumulation at the tumor site. Soy lecithin and cholesterol at a 9:1 ratio were
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Synthesis and characterization of levan hydrogels and their use for resveratrol release J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2021-10-29 Sinem Selvin Selvi, Merve Erginer Hasköylü, Seval Genç, Ebru Toksoy Öner
Considering the need for systematic studies on levan based hydrogels to widen their use in drug delivery systems and biomedical applications, this study is mainly focused on the synthesis and comprehensive characterization as well as drug release properties of hydrogels based on Halomonas levan (HL) and its chemical derivatives. For this, hydrolyzed and phosphonated HL derivatives were chemically synthesized
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Development of poly(ethyleneimine) grafted amphiphilic copolymers: Evaluation of their cytotoxicity and ability to complex DNA J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2021-10-28 Ivonne L Diaz, Valérie Jérôme, Ruth Freitag, León D Perez
Poly(ethyleneimine) (PEI) is one of the most widely used cationic polymers for gene delivery. The high molecular weight polymer, which is commercially available, is highly efficient but also very cytotoxic. The reduction in charge density by using nonlinear architectures based on low molecular weight (LMW) PEI is a promising approach to produce safer DNA-vectors. Herein, a group of cationic graft copolymers
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Osteo-conductive hydrogel scaffolds of poly(vinylalcohol) with silk fibroin particles for bone augmentation: Structural formation and in vitro testing J. Bioact. Compat. Polym. (IF 1.7) Pub Date : 2021-10-25 Dan Zhao, Thongchai Nuntanaranont, Nuttawut Thuaksubun, Jirut Meesane
Bone augmentation is an effective approach to treat patients who have bone loss at the maxillofacial area. In this research, osteo-conductive hydrogel scaffolds of poly(vinylalcohol) (PVA) with silk fibroin particles (SFP) were fabricated. The SFP were formed by dropping a solution of silk fibroin into acetone at different volume ratios (v/v) of silk to acetone: 1:3 (SFP-3), 1:6 (SFP-6), 1:12 (SFP-12)