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pH-responsive size-adjustable liposomes induce apoptosis of fibroblasts and macrophages for rheumatoid arthritis treatment Acta Biomater. (IF 9.7) Pub Date : 2024-03-12 Xiu Zheng, Hong Yang, Zongquan Zhang, Xiaoya Liang, Yan Liu, Chenglong Wang, Xi Yang, Jun Tang, Jingying Mao, Yu Nie, Xiangyu Zhou, Chunhong Li
In rheumatoid arthritis (RA), macrophages infiltrate joints, while fibroblast-like synovial cells proliferate abnormally, forming a barrier against drug delivery, which hinders effective drug delivery to joint focus. Here we firstly designed a pH-responsive size-adjustable nanoparticle, composed by methotrexate (MTX)-human serum albumin (HSA) complex coating with pH-responsive liposome (Lipo/MTX-HSA)
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Influence of intramedullary pressure on lacuno-canalicular fluid flow: a systematic review Acta Biomater. (IF 9.7) Pub Date : 2024-03-12 Cassandra Fernandes Da Costa, Nina Attik, Remy Gauthier
While most of current models investigating bone remodelling are based on matrix deformation, intramedullary pressure also plays a role. Bone remodelling is orchestrated by the Lacuno-Canalicular Network (LCN) fluid-flow. The aim of this review was hence to assess the influence of intramedullary pressure on the fluid circulation within the LCN. Three databases (Science Direct, Web of Science, and PubMed)
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A magnesium screw with optimized geometry exhibits improved corrosion resistance and favors bone fracture healing Acta Biomater. (IF 9.7) Pub Date : 2024-03-11 Ying Luo, Fangfei Liu, Zhuoxuan Chen, Yong Luo, Weirong Li, Jiali Wang
Stress-induced corrosion impairs the mechanical integrity of magnesium (Mg) and its alloys as potential orthopedic implants. Although there has been extensive work reporting the effects of stress on Mg corrosion in vitro, the geometric design principles of the Mg-based orthopedic devices still remain largely unknown. In this work, a numerical simulation model mimicking fractured bone fixation and surgical
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Guinea fowl eggshell structural analysis at different scales reveals how organic matrix induces microstructural shifts that enhance its mechanical properties Acta Biomater. (IF 9.7) Pub Date : 2024-03-07 A.B. Rodríguez-Navarro, N. Domínguez-Gasca, D. Athanasiadou, N. Le Roy, A. González-Segura, N. Reznikov, M.T. Hincke, M.D. McKee, A.G. Checa, Y. Nys, J. Gautron
Guinea fowl eggshells have an unusual structural arrangement that is different from that of most birds, consisting of two distinct layers with different microstructures. This bilayered organization, and distinct microstructural characteristics, provides it with exceptional mechanical properties. The inner layer, constituting about one third of the eggshell thickness, contains columnar calcite crystal
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A Nanomedicine Composed of Polymer-ss-DOX and Polymer-Ce6 Prodrugs with Monoclonal Antibody Targeting Effect for Anti-tumor Chemo-Photodynamic Synergetic Therapy Acta Biomater. (IF 9.7) Pub Date : 2024-03-07 Liang Yu, Mingzu Zhang, Jinlin He, Xingwei Sun, Peihong Ni
Anticancer drugs used for systemic chemotherapy often exhibit off-target toxicity and uncontrolled drug release due to their lack of targeting. To improve the bioavailability of drugs and reduce side effects, we have developed a mixed micelle of nanomedicine composed of two prodrugs with surface modified monoclonal antibody for cancer therapy. In this system, Nimotuzumab was used as targeting ligands
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Printing of 3D biomimetic structures for the study of bone metastasis: a review Acta Biomater. (IF 9.7) Pub Date : 2024-03-07 Mehdi Khanmohammadi, Marina Volpi, Ewa Walejewska, Alicja Olszewska, Wojciech Swieszkowski
Bone metastasis primarily occurs when breast, prostate, or lung cancers disseminate tumoral cells into bone tissue, leading to a range of complications in skeletal tissues and, in severe cases, paralysis resulting from spinal cord compression. Unfortunately, our understanding of pathophysiological mechanisms is incomplete and the translation of bone metastasis research into the clinic has been slow
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Water-compatible cross-linked pyrrolidone acrylate pressure-sensitive adhesives with persistent adhesion for transdermal delivery: Synergistic effect of hydrogen bonding and electrostatic force Acta Biomater. (IF 9.7) Pub Date : 2024-03-07 Kaihua Gong, Peng Sun, Yu Cai, Xiaoxu Wang, Yu Pang, Chao Liu, Jianpeng Guo, Liang Fang
Poor skin adhesion and mechanical properties are common problems of pressure-sensitive adhesive (PSA) in transdermal drug delivery system (TDDS). Its poor water compatibility also causes the patch to fall off after sweating or soaking in the application site. To solve this problem, poly (2-Ethylhexyl acrylate---Vinyl-2-pyrrolidone---(2-Hydroxyethyl)acrylamide) (PENH), a cross-linked pyrrolidone polyacrylate
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Adhesive hydrogel releases protocatechualdehyde-Fe3+ complex to promote three healing stages for accelerated therapy of oral ulcers Acta Biomater. (IF 9.7) Pub Date : 2024-03-05 Yue Wang, Ziyi Pan, Jing Cui, Xu Zhang, Daowei Li, Hongchen Sun, Bai Yang, Yunfeng Li
Oral ulcers can significantly reduce the life quality of patients and even lead to malignant transformations. Local treatments using topical agents are often ineffective because of the wet and dynamic environment of the oral cavity. Current clinical treatments for oral ulcers, such as corticosteroids, have limitations and side effects for long-term usage. Here, we develop adhesive hydrogel patches
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Active Immunotherapy for C5a-mediated Inflammation Using Adjuvant-free Self-Assembled Peptide Nanofibers Acta Biomater. (IF 9.7) Pub Date : 2024-03-05 Kelly M Hainline, Helena Freire Haddad, Anna Gilpin, Elizabeth J Curvino, Shyni Varghese, Joel H Collier
The terminal protein in the complement cascade C5a is a potent inflammatory molecule and chemoattractant that is involved in the pathology of multiple inflammatory diseases including sepsis and arthritis, making it a promising protein to target with immunotherapies. Active immunotherapies, in which patients are immunized against problematic self-molecules and generate therapeutic antibodies as a result
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Shear stress activates the Piezo1 channel to facilitate valvular endothelium-oriented differentiation and maturation of human induced pluripotent stem cells Acta Biomater. (IF 9.7) Pub Date : 2024-03-05 Minghui Xie, Hong Cao, Weihua Qiao, Ge Yan, Xingyu Qian, Yecen Zhang, Li Xu, Shuyu Wen, Jiawei Shi, Min Cheng, Nianguo Dong
Valvular endothelial cells (VECs) derived from human induced pluripotent stem cells (hiPSCs) provide an unlimited cell source for tissue engineering heart valves (TEHVs); however, they are limited by their low differentiation efficiency and immature function. In our study, we applied unidirectional shear stress to promote hiPSCs differentiation into valvular endothelial-like cells (VELs). Compared
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Telodendrimer functionalized hydrogel platform for sustained antibiotics release in infection control Acta Biomater. (IF 9.7) Pub Date : 2024-03-05 Xiguang Yang, Dandan Guo, Xiaotian Ji, Changying Shi, Jennifer M. Messina, Liye Suo, Juntao Luo
Wound infection commonly causes delayed healing, especially in the setting of chronic wounds. Local release of antibiotics is considered a viable approach to treat chronic wounds. We have developed a versatile telodendrimer (TD) platform for efficient loading of charged antibiotic molecules via a combination of multivalent and synergistic charge and hydrophobic interactions. The conjugation of TD in
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Anti-fibrotic and anti-stricture effects of biodegradable biliary stents braided with dexamethasone-impregnated sheath/core structured monofilaments Acta Biomater. (IF 9.7) Pub Date : 2024-03-04 Ju-Ro Lee, Seung Won Yang, Chang-Il Kwon, Kyu Seok Kim, Se Hwan Park, Myeong Jin Jang, Ga Hee Kim, Min Je Sung, Gwangil Kim, Jun Sik Son, Yoon Ki Joung
Endoscopic biliary stent insertion has been widely used for the treatment of benign biliary stricture (BBS). Thus, the development of stent materials in the perspectives of structure, mechanical properties, and biocompatibility has been also studied. However, conventional metal and plastic stents have several disadvantages, such as repeated procedures to remove or exchange them, dislodgment, restenosis
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Bioresorbable molybdenum temporary epicardial pacing wires Acta Biomater. (IF 9.7) Pub Date : 2024-03-02 Maria-Elisa Prieto Jarabo, Christian Redlich, Antje Schauer, Paula Ketilly Nascimento Alves, Celine Guder, Georg Poehle, Thomas Weissgaerber, Volker Adams, Utz Kappert, Ali El-Armouche, Axel Linke, Michael Wagner
Cardiac pacing with temporary epicardial pacing wires (TEPW) is used to treat rhythm disturbances after cardiac surgery. Occasionally, TEPW cannot be mechanically extracted and remain in the thorax, where they may rarely cause serious complications like migration and infection. We aim to develop bioresorbable TEPW that will dissolve over time even if postoperative removal is unsuccessful. In the present
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A transporter that allows phosphate ions to control the polymorph of exoskeletal calcium carbonate biomineralization Acta Biomater. (IF 9.7) Pub Date : 2024-02-29 Shai A. Shaked, Shai Abehsera, Andreas Ziegler, Shmuel Bentov, Rivka Manor, Simy Weil, Ehud Ohana, Jerry Eichler, Eliahu D. Aflalo, Amir Sagi
The SLC20A2 transporter supplies phosphate ions (P) for diverse biological functions in vertebrates, yet has not been studied in crustaceans. Unlike vertebrates, whose skeletons are mineralized mainly by calcium phosphate, only minute amounts of P are found in the CaCO-mineralized exoskeletons of invertebrates. In this study, a crustacean SLC20A2 transporter was discovered and P transport to exoskeletal
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Enzymatic digestion does not compromise sliding-mediated cartilage lubrication Acta Biomater. (IF 9.7) Pub Date : 2024-02-28 Meghan E. Kupratis, Atia Rahman, David L. Burris, Elise A. Corbin, Christopher Price
Articular cartilage's remarkable low-friction properties are essential to joint function. In osteoarthritis (OA), cartilage degeneration (, proteoglycan loss and collagen damage) decreases tissue modulus and increases permeability. Although these changes impair lubrication in fully depressurized and slowly slid cartilage, new evidence suggests such relationships may not hold under biofidelic sliding
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Multimodal characterization of the collagen hydrogel structure and properties in response to physiologically relevant pH fluctuations Acta Biomater. (IF 9.7) Pub Date : 2024-02-28 Orit Bronner-Shtrauchler, Einat Nativ-Roth, Daniel Sevilla Sanchez, Michal Zaiden, Netta Vidavsky
pH fluctuations within the extracellular matrix (ECM) and its principal constituent collagen, particularly in solid tumors and chronic wounds, may influence its structure and function. Whereas previous research examined the impact of pH on collagen fibrillogenesis, this study focuses on determining how pH fluctuations affect collagen hydrogels that mimic the physiological ECM. Utilizing a type I collagen
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Biologically produced and metal-organic framework delivered dual-cut CRISPR/Cas9 system for efficient gene editing and sensitized cancer therapy Acta Biomater. (IF 9.7) Pub Date : 2024-02-28 Jiantao Yu, Mao Tang, Zhengdong Zhou, Zixiang Wei, Feiyan Wan, Shengxin Hou, Qing Li, Yan Li, Leilei Tian
Manipulation of the lactate metabolism is an efficient way for cancer treatment given its involvement in cancer development, metastasis, and immune escape. However, most of the inhibitors of lactate transport carriers suffer from poor specificity. Herein, we use the CRISPR/Cas9 system to precisely downregulate the monocarboxylate carrier 1 (MCT1) expression. To avoid the self-repairing during the gene
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Characterizing the Microstructures of Mammalian Enamel by Synchrotron Phase Contrast microCT Acta Biomater. (IF 9.7) Pub Date : 2024-02-28 C. Marsico, J.R. Grimm, C. Renteria, D.P. Guillen, K. Tang, V. Nikitin, D.D. Arola
The enamel of mammalian teeth is a highly mineralized tissue that must endure a lifetime of cyclic contact and is inspiring the development of next-generation engineering materials. Attempts to implement enamel-inspired structures in synthetic materials have had limited success, largely due to the absence of a detailed understanding of its microstructure. The present work used synchrotron phase-contrast
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Refractive index adjustable intraocular lens design to achieve diopter control for improving the treatment of ametropia after cataract surgery Acta Biomater. (IF 9.7) Pub Date : 2024-02-27 Yueze Hong, Dong Liu, Haoyu Zou, Qingqing Jia, Sihan Tang, Quankui Lin
Intraocular lens (IOL) implantation is currently the most effective clinical treatment for cataracts. Nevertheless, due to the growth of the eye axis in patients with congenital cataracts during the process of growth and development, the progressive incapacity of an IOL with a fixed focus does not meet the demands of practical usage, leading to the occurrence of ametropia. This work describes an innovative
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Bacterial extracellular vesicles: Modulation of biofilm and virulence properties Acta Biomater. (IF 9.7) Pub Date : 2024-02-27 Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Kyung-Jin Cho, Young-Mog Kim
Microbial pathogens cause persistent infections by forming biofilms and producing numerous virulence factors. Bacterial extracellular vesicles (BEVs) are nanostructures produced by various bacterial species vital for molecular transport. BEVs include various components, including lipids (glycolipids, LPS, and phospholipids), nucleic acids (genomic DNA, plasmids, and short RNA), proteins (membrane proteins
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pH-responsive CuS/DSF/EL/PVP nanoplatform alleviates inflammatory bowel disease in mice via regulating gut immunity and microbiota Acta Biomater. (IF 9.7) Pub Date : 2024-02-27 Jinpeng Yao, Yu Chen, Liang Zhang, Yuancun Cheng, Zheng Chen, Yanhui Zhang, Xiaoyi Zheng, Yanwei Lv, Shige Wang, Zhaoshen Li, Jiulong Zhao
The clinical treatment of inflammatory bowel disease (IBD) is challenging. We developed copper sulfate (CuS)/disulfiram (DSF)/methacrylic acid-ethyl acrylate copolymer (EL)/polyvinylpyrrolidone (PVP) nanoplatform (CuS/DSF/EL/PVP) and evaluated its efficiency for treating IBD. After oral administration, the pH-sensitive EL protected the CuS/DSF/EL/PVP against degradation by acidic gastric juices. Once
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Mechanical design principles of avian eggshells for survivability Acta Biomater. (IF 9.7) Pub Date : 2024-02-27 Fan Liu, Xihang Jiang, Zi Chen, Lifeng Wang
Biological materials exhibit complex structure-property relationships which are designed by nature's evolution over millions of years. Unlocking the fundamental physical principles behind these relationships is crucial for creating bioinspired materials and structures with advanced functionalities. The eggshell is a remarkable example with a well-designed structure to balance the trade-off as it provides
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High-density zwitterionic polymer brushes exhibit robust lubrication properties and high antithrombotic efficacy in blood-contacting medical devices Acta Biomater. (IF 9.7) Pub Date : 2024-02-27 Xinzhong Song, Jia Man, Yinghua Qiu, Jiali Wang, Jianing Liu, Ruijian Li, Yongqi Zhang, Jianyong Li, Jianfeng Li, Yuguo Chen
High-performance catheters are essential for interventional surgeries, requiring reliable anti-adhesive and lubricated surfaces. This article develops a strategy for constructing high-density sulfobetaine zwitterionic polymer brushes on the surface of catheters, utilizing dopamine and sodium alginate as the primary intermediate layers, where dopamine provides mussel-protein-like adhesion to anchor
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Increasing temperature accelerates Ti-6Al-4V oxide degradation and selective dissolution: An Arrhenius-based analysis Acta Biomater. (IF 9.7) Pub Date : 2024-02-27 Michael A. Kurtz, Kazzandra Alaniz, Lilliana M. Taylor, Aldo Moreno-Reyes, Jeremy L. Gilbert
Ti-6Al-4V selective dissolution occurs on orthopedic implants as the leading edge of a pitting corrosion attack. A gap persists in our fundamental understanding of selective dissolution and pre-clinical tests fail to reproduce this damage. While CoCrMo clinical use decreases, Ti-6Al-4V and the crevice geometries where corrosion can occur remain ubiquitous in implant design. Additionally, most additively
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Multimodal experimental studies of the passive mechanical behavior of human aortas: current approaches and future directions Acta Biomater. (IF 9.7) Pub Date : 2024-02-22 Anna Pukaluk, Gerhard Sommer, Gerhard A. Holzapfel
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Cationized Orthogonal Triad as a Photosensitizer with Enhanced Synergistic Antimicrobial Activity Acta Biomater. (IF 9.7) Pub Date : 2024-02-21 Xiaoying Hao, Ying Tang, Ruiling Zhang, Zigeng Wang, Min Gao, Ran Wei, Yongxian Zhao, Xueluer Mu, Yingxi Lu, Xianfeng Zhou
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Biodegradation-affected fatigue behavior of extrusion-based additively manufactured porous iron–manganese scaffolds Acta Biomater. (IF 9.7) Pub Date : 2024-02-21 Niko E. Putra, Vahid Moosabeiki, Marius A. Leeflang, Jie Zhou, Amir A. Zadpoor
Additively manufactured (AM) biodegradable porous iron-manganese (FeMn) alloys have recently been developed as promising bone-substituting biomaterials. However, their corrosion fatigue behavior has not yet been studied. Here, we present the first study on the corrosion fatigue behavior of an extrusion-based AM porous Fe35Mn alloy under cyclic loading in air and in the revised simulated body fluid
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Magnesium-lithium thin films for neurological applications–An in vitro investigation of glial cytocompatibility and neuroinflammatory response Acta Biomater. (IF 9.7) Pub Date : 2024-02-20 Krathika Bhat, Luise Schlotterose, Lisa Hanke, Heike Helmholz, Eckhard Quandt, Kirsten Hattermann, Regine Willumeit-Römer
Lithium (Li), a widely used drug for bipolar disorder management, is associated with many side effects due to systemic exposure. The localized delivery of lithium through implants could be an approach to overcome this challenge, for which biodegradable magnesium (Mg)-based materials are a promising choice. In this study, we focus on Mg-Li thin film alloys as potential Li-releasing implants. Therefore
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Increased matrix stiffness enhances pro-tumorigenic traits in a physiologically relevant breast tissue- monocyte 3D model Acta Biomater. (IF 9.7) Pub Date : 2024-02-20 Annelie Abrahamsson, Fatemeh Rasti Boroojeni, Sajjad Naeimipour, Nina Reustle, Robert Selegård, Daniel Aili, Charlotta Dabrosin
High mammographic density, associated with increased tissue stiffness, is a strong risk factor for breast cancer . In postmenopausal women there is no differences in the occurrence of ductal carcinoma in situ (DCIS) depending on breast density. Preliminary data suggest that dense breast tissue is associated with a pro-inflammatory microenvironment including infiltrating monocytes. However, the underlying
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Bone mimetic environments support engineering, propagation, and analysis of therapeutic response of patient-derived cells, ex vivo and in vivo Acta Biomater. (IF 9.7) Pub Date : 2024-02-20 Claudia Paindelli, Vanessa Parietti, Sergio Barrios, Peter Shepherd, Tianhong Pan, Wei-Lien Wang, Robert Satcher, Christopher J. Logothetis, Nora Navone, Matthew T. Campbell, Antonios G. Mikos, Eleonora Dondossola
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Microfluidics-Derived Hierarchical Microparticles for the Delivery of Dienogest for Localized Endometriosis Therapy Acta Biomater. (IF 9.7) Pub Date : 2024-02-20 Meiling Wu, Qingfei Zhang, Luoran Shang, Ping Duan
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Designed modular protein hydrogels for biofabrication Acta Biomater. (IF 9.7) Pub Date : 2024-02-19 Dalia Dranseike, Yusuke Ota, Thomas G.W. Edwardson, Elia A. Guzzi, Mao Hori, Zrinka Raguz Nakic, Dhananjay V. Deshmukh, Mikail D. Levasseur, Kevin Mattli, Christina M. Tringides, Jiangtao Zhou, Donald Hilvert, Christin Peters, Mark W. Tibbitt
Designing proteins that fold and assemble over different length scales provides a way to tailor the mechanical properties and biological performance of the resulting hydrogels. In this study, we designed modular proteins that self-assemble into fibrillar networks and, as a result, form hydrogel materials. We incorporated distinct functionalities by connecting separate self-assembling ( block) and cell-binding
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Generation of 3D melanoma models using an assembloid-based approach Acta Biomater. (IF 9.7) Pub Date : 2024-02-19 Daniel B. Rodrigues, Helena R. Moreira, Mariana Jarnalo, Ricardo Horta, Alexandra P. Marques, Rui L. Reis, Rogério P. Pirraco
While 3D tumor models have greatly evolved over the past years, there is still a strong requirement for more biosimilar models which are capable of recapitulating cellular crosstalk within the tumor microenvironment while equally displaying representative levels of tumor aggressiveness and invasion. Herein, we disclose an assembloid melanoma model based on the fusion of individual stromal multicellular
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Mechanically tough, adhesive, self-healing hydrogel promotes annulus fibrosus repair via autologous cell recruitment and microenvironment regulation Acta Biomater. (IF 9.7) Pub Date : 2024-02-19 Zhenyuan Wei, Han Ye, Yucai Li, Xiaoxiao Li, Yi Liu, Yujie Chen, Jiangming Yu, Jielin Wang, Xiaojian Ye
Annulus fibrosus (AF) defect is an important cause of disc re-herniation after discectomy. The self-regeneration ability of the AF is limited, and AF repair is always hindered by the inflammatory microenvironment after injury. Hydrogels represent one of the most promising materials for AF tissue engineering strategies. However, currently available commercial hydrogels cannot withstand the harsh mechanical
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Refining nanoprobes for monitoring of inflammatory bowel disease Acta Biomater. (IF 9.7) Pub Date : 2024-02-15 Ruchen Yao, Mingming Zhu, Zhiqian Guo, Jun Shen
Inflammatory bowel disease (IBD) is a gastrointestinal immune disease that requires clear diagnosis, timely treatment, and lifelong monitoring. The diagnosis and monitoring methods of IBD mainly include endoscopy, imaging examination, and laboratory examination, which are constantly developed to achieve early definite diagnosis and accurate monitoring. In recent years, with the development of nanotechnology
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A Biomaterial Platform for T Cell-Specific Gene Delivery Acta Biomater. (IF 9.7) Pub Date : 2024-02-15 Sharda Pandit, Blake E. Smith, Michael E. Birnbaum, Yevgeny Brudno
Efficient T cell engineering is central to the success of CAR T cell therapy but involves multiple time-consuming manipulations, including T cell isolation, activation, and transduction. These steps add complexity and delay CAR T cell manufacturing, which takes a mean time of 4 weeks. To streamline T cell engineering, we strategically combine two critical engineering solutions - T cell-specific lentiviral
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Bone ingrowth into a porous structure is achieved by preceding fibrogenesis and vascularization Acta Biomater. (IF 9.7) Pub Date : 2024-02-15 Yusuke Takaoka, Shunsuke Fujibayashi, Hirotaka Onoe, Koji Goto, Bungo Otsuki, Toshiyuki Kawai, Yaichiro Okuzu, Takayoshi Shimizu, Norimasa Ikeda, Kazuki Orita, Shintaro Honda, Tatsuhito Ikezaki, Takeshi Yabutsuka, Shuichi Matsuda
Porous structures are frequently used in surgical implants to strengthen the interlocking power produced by bone ingrowth. Therefore, we aimed to elucidate the mechanism underlying bone ingrowth into a porous structure accompanied by vascularization. A nonbioactive polyetheretherketone implant with a 3D-printed porous structure was prepared and implanted in a bone hole created in the tibias of rabbits
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Toughening 3D printed biomimetic hydroxyapatite scaffolds: polycaprolactone-based self-hardening inks Acta Biomater. (IF 9.7) Pub Date : 2024-02-14 Laura del-Mazo-Barbara, Linh Johansson, Francesco Tampieri, Maria-Pau Ginebra
The application of 3D printing to calcium phosphates has opened unprecedented possibilities for the fabrication of personalized bone grafts. However, their biocompatibility and bioactivity are counterbalanced by their high brittleness. In this work we aim at overcoming this problem by developing a self-hardening ink containing reactive ceramic particles in a polycaprolactone solution instead of the
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Nanoparticle-mediated blockade of CXCL12/CXCR4 signaling enhances glioblastoma immunotherapy: Monitoring early responses with MRI radiomics Acta Biomater. (IF 9.7) Pub Date : 2024-02-14 Ruili Wei, Jiamin Li, Wanxian Lin, Xinrui Pang, Huikang Yang, Shengsheng Lai, Xinhua Wei, Xinqing Jiang, Youyong Yuan, Ruimeng Yang
The limited therapeutic efficacy of checkpoint blockade immunotherapy against glioblastoma is closely related to the blood-brain barrier (BBB) and tumor immunosuppressive microenvironment, where the latter is driven primarily by tumor-associated myeloid cells (TAMCs). Targeting the C-X-C motif chemokine ligand-12/C-X-C motif chemokine receptor-4 (CXCL12/CXCR4) signaling orchestrates the recruitment
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TiO2 nanotube topography enhances osteogenesis through filamentous actin and XB130-protein-mediated mechanotransduction Acta Biomater. (IF 9.7) Pub Date : 2024-02-14 Yongyun Chang, Keyu Kong, Zhicheng Tong, Hua Qiao, Minghao Jin, Xinru Wu, Zhengxiao Ouyang, Jingwei Zhang, Zanjing Zhai, Huiwu Li
TiO nanotube topography, as nanomechanical stimulation, can significantly promote osteogenesis and improve the osteointegration on the interface of implants and bone tissue. However, the underlying mechanism has not been fully elucidated. XB130 is a member of the actin filament-associated protein family and is involved in the regulation of cytoskeleton and tyrosine kinase-mediated signalling as an
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Viscoelastic stiffening of gelatin hydrogels for dynamic culture of pancreatic cancer spheroids Acta Biomater. (IF 9.7) Pub Date : 2024-02-12 Han Nguyen, Chien-Chi Lin
The tumor microenvironment (TME) in pancreatic adenocarcinoma (PDAC) is a complex milieu of cellular and non-cellular components. Pancreatic cancer cells (PCC) and cancer-associated fibroblasts (CAF) are two major cell types in PDAC TME, whereas the non-cellular components are enriched with extracellular matrices (ECM) that contribute to high stiffness and fast stress-relaxation. Previous studies have
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Digital light 4D printing of bioresorbable shape memory elastomers for personalized biomedical implantation Acta Biomater. (IF 9.7) Pub Date : 2024-02-12 Alireza Mahjoubnia, Dunpeng Cai, Yuchao Wu, Skylar D. King, Pooya Torkian, Andy C. Chen, Reza Talaie, Shi-You Chen, Jian Lin
Four-dimensional (4D) printing unlocks new potentials for personalized biomedical implantation, but still with hurdles of lacking suitable materials. Herein, we demonstrate a bioresorbable shape memory elastomer (SME) with high elasticity at both below and above its phase transition temperature (). This SME can be digital light 3D printed by co-polymerizing glycerol dodecanoate acrylate prepolymer
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Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts Acta Biomater. (IF 9.7) Pub Date : 2024-02-11 Mehmet Nizamoglu, Frederique Alleblas, Taco Koster, Theo Borghuis, Judith M. Vonk, Matthew J. Thomas, Eric S. White, Carolin K. Watson, Wim Timens, Karim C. El Kasmi, Barbro N. Melgert, Irene H. Heijink, Janette K. Burgess
Idiopathic pulmonary fibrosis (IPF), for which effective treatments are limited, results in excessive and disorganized deposition of aberrant extracellular matrix (ECM). An altered ECM microenvironment is postulated to contribute to disease progression through inducing profibrotic behavior of lung fibroblasts, the main producers and regulators of ECM. Here, we examined this hypothesis in a 3D model
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Incorporation of poly(γ-glutamic acid) in lipid nanoparticles for enhanced mRNA delivery efficiency in vitro and in vivo Acta Biomater. (IF 9.7) Pub Date : 2024-02-10 Hongqian Zhang, Xue Gao, Qian Sun, Xiaoxue Dong, Zongwei Zhu, Chuanxu Yang
Messenger RNA (mRNA)-based therapy shows immense potential for broad biomedical applications. However, the development of safe and efficacious mRNA delivery vectors remains challenging due to delivery barriers and inefficient intracellular payload release. Herein, we presented a simple strategy to boost the mRNA intracellular release by incorporation of anionic poly(γ-glutamic acid) (PGA) into an ionizable
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Micrometer-scale structure in shark vertebral centra Acta Biomater. (IF 9.7) Pub Date : 2024-02-09 S.R. Stock, U. Kierdorf, K.C. James, P.D. Shevchenko, L.J. Natanson, S. Gomez, H. Kierdorf
The vertebral centra of sharks consist of cartilage, and many species’ centra contain a bioapatite related to that in bone. Centra microarchitectures at the 0.5-50 µm scale do not appear to have been described previously. This study examines centrum microarchitecture in lamniform and carcharhiniform sharks with synchrotron microComputed Tomography (microCT), scanning electron microscopy and spectroscopy
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Impact of multiscale surface topography characteristics on Candida albicans biofilm formation: from cell repellence to fungicidal activity Acta Biomater. (IF 9.7) Pub Date : 2024-02-09 Phuc H. Le, Denver P. Linklater, Arturo Aburto Medina, Shane MacLaughlin, Russell J. Crawford, Elena P. Ivanova
While there has been significant research conducted on bacterial colonization on implant materials, with a focus on developing surface modifications to prevent the formation of bacterial biofilms, the study of biofilms on implantable materials is still in its infancy, despite its growing relevance in implant-associated infections. fungal infections represent a significant clinical concern due to their
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A homologous-targeting cGAS-STING agonist multimodally activates dendritic cells for enhanced cancer immunotherapy Acta Biomater. (IF 9.7) Pub Date : 2024-02-08 Peng Wang, Yinfeng Wang, Huimin Li, Miaomiao Wang, Yue Wang, Xiaofei Wang, Lang Ran, Huan Xin, Jingyi Ma, Geng Tian, Wenjuan Gao, Guilong Zhang
Herein, we developed a doxorubicin (Dox)-loaded and 4T1 cancer cell membrane-modified hydrogenated manganese oxide nanoparticles (mHMnO-Dox) to elicit systemic antitumor immune responses. The results revealed that mHMnO-Dox actively recognized tumor cells and then effectively delivered Dox into the cells. Upon entering tumor cells, the mHMnO-Dox underwent rapid degradation and abundant release of Mn
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Fibrin clot fracture under cyclic fatigue and variable rate loading Acta Biomater. (IF 9.7) Pub Date : 2024-02-08 Shiyu Liu, Aram Bahmani, Farshid Ghezelbash, Jianyu Li
Fibrin clot is a of vital class of fibrous materials, governing the mechanical response blood clots. Fracture behavior of fibrin clots under complex physiological load is relevant for hemostasis and thrombosis. But how they fracture under cyclic and variable rate loading has not been reported. Here we conduct cyclic fatigue and monotonic variable rate loading tests on fibrin clots to characterize their
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Type I photodynamic antimicrobial therapy: Principles, progress, and future perspectives Acta Biomater. (IF 9.7) Pub Date : 2024-02-07 Jingai Jiang, Xinyi Lv, Huijuan Cheng, Dongliang Yang, Wenjia Xu, Yanling Hu, Yanni Song, Guisheng Zeng
The emergence of drug-resistant bacteria has significantly diminished the efficacy of existing antibiotics in the treatment of bacterial infections. Consequently, the need for finding a strategy capable of effectively combating bacterial infections has become increasingly urgent. Photodynamic therapy (PDT) is considered one of the most promising emerging antibacterial strategies due to its non-invasiveness
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A pH-responsive Cetuximab-conjugated DMAKO-20 Nano-delivery System for Overcoming K-ras Mutations and Drug Resistance in Colorectal Carcinoma Acta Biomater. (IF 9.7) Pub Date : 2024-02-06 Huiling Song, Haosheng Li, Xiaonan Shen, Kuai Liu, Haoran Feng, Jiahua Cui, Wei Wei, Xiaolu Sun, Qiong Fan, Wei Bao, Haiyan Zhou, Liheng Qian, Huizhen Nie, Xi Cheng, Zixiu Du
Cetuximab (Cet) and oxaliplatin (OXA) are used as first-line drugs for patients with colorectal carcinoma (CRC). In fact, the heterogeneity of CRC, mainly caused by K-ras mutations and drug resistance, undermines the effectiveness of drugs. Recently, a hydrophobic prodrug, (1E,4E)-6-((S)-1-(isopentyloxy)-4-methylpent-3-en-1-yl)-5,8-dimethoxynaphthalene-1,4-dione dioxime (DMAKO-20), has been shown to
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Single-Cell Coating with Biomimetic Extracellular Nanofiber Matrices Acta Biomater. (IF 9.7) Pub Date : 2024-02-06 Slgirim Lee, James K. Carrow, Lewis A. Fraser, Jianglong Yan, Shareni Jeyamogan, Yuvaraj Sambandam, Tristan D. Clemons, Alexandra N. Kolberg-Edelbrock, Jie He, James Mathew, Zheng Jenny Zhang, Joseph P. Leventhal, Lorenzo Gallon, Liam C. Palmer, Samuel I. Stupp
Cell therapies offer great promise in the treatment of diseases and tissue regeneration, but their clinical use has many challenges including survival, optimal performance in their intended function, or localization at sites where they are needed for effective outcomes. We report here on a method to coat a biodegradable matrix of biomimetic nanofibers on single cells that could have specific functions
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Minimally invasive delivery of human umbilical cord-derived mesenchymal stem cells by an injectable hydrogel via Diels–Alder click reaction for the treatment of intrauterine adhesions Acta Biomater. (IF 9.7) Pub Date : 2024-02-06 Sentao Hu, Yangyang Dai, Liaobing Xin, Xiaowen Zheng, Zi Ye, Songying Zhang, Lie Ma
Intrauterine adhesions (IUA) are the most common cause of uterine infertility, and conventional treatments have not consistently achieved satisfactory pregnancy rates. Stem cell therapy shows promising potential for the clinical treatment of IUA. Although various advanced biomaterials have been designed for delivering stem cells to the uterine cavity, there remain significant challenges, particularly
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The bone morphogenetic protein 2 analogue L51P enhances spinal fusion in combination with BMP2 in an in vivo rat tail model Acta Biomater. (IF 9.7) Pub Date : 2024-02-06 Benjamin Gantenbein, Katharina A.C. Oswald, Georg F. Erbach, Andreas S. Croft, Paola Bermudez-Lekerika, Franziska Strunz, Sebastian F. Bigdon, Christoph E. Albers
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Bone cell response to additively manufactured 3D micro-architectures with controlled Poisson's ratio: Auxetic vs. non-auxetic meta-biomaterials Acta Biomater. (IF 9.7) Pub Date : 2024-02-06 Ebrahim Yarali, Maria Klimopoulou, Kristen David, Pouyan E. Boukany, Urs Staufer, Lidy E. Fratila-Apachitei, Amir A. Zadpoor, Angelo Accardo, Mohammad J. Mirzaali
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Dressing and undressing MOF nanophotosensitizers to manipulate phototoxicity for precise therapy of tumors Acta Biomater. (IF 9.7) Pub Date : 2024-02-06 Cheng Tao, Nuo Yu, Qian Ren, Mei Wen, Pu Qiu, Shining Niu, Maoquan Li, Zhigang Chen
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Characterization of the molecular composition and in vitro regenerative capacity of platelet-based bioproducts and related subfractions Acta Biomater. (IF 9.7) Pub Date : 2024-02-03 Andrea Acebes-Huerta, Patricia Martínez-Botía, Graciela Carbajo-Argüelles, Judit Fernández-Fuertes, María Carmen Muñoz-Turrillas, Ana María Ojea-Pérez, Antonio López-Vázquez, Johannes A. Eble, Laura Gutiérrez
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Mesoporous bioactive glass scaffolds for the delivery of bone marrow stem cell-derived osteoinductive extracellular vesicles lncRNA promote senescent bone defect repair by targeting the miR-1843a-5p/Mob3a/YAP axis Acta Biomater. (IF 9.7) Pub Date : 2024-02-02 Lei Qi, Cancan Pan, Jinge Yan, Weiwen Ge, Jing Wang, Lu Liu, Lei Zhang, Dan Lin, Steve G.F. Shen
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M2 macrophage-derived exosome-functionalized topological scaffolds regulate the foreign body response and the coupling of angio/osteoclasto/osteogenesis Acta Biomater. (IF 9.7) Pub Date : 2024-02-02 Shue Jin, Jing Wen, Yao Zhang, Ping Mou, Zeyu Luo, Yongrui Cai, Anjin Chen, Xiaoxue Fu, Weikun Meng, Zongke Zhou, Jidong Li, Weinan Zeng
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Dumbbell-shaped bimetallic AuPd nanoenzymes for NIR-II cascade catalysis-photothermal synergistic therapy Acta Biomater. (IF 9.7) Pub Date : 2024-02-02 Zhe Tang, Yike Hou, Shuqi Huang, Narayan S. Hosmane, Mingyue Cui, Xianan Li, Muhammad Suhail, Han Zhang, Jian Ge, M Zubair Iqbal, Xiangdong Kong