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Platelet Lysates-based Hydrogels Incorporating Bioactive Mesoporous Silica Nanoparticles for Stem Cell Osteogenic Differentiation Mater. Today Bio Pub Date : 2021-01-23 Márcia T. Tavares; Sara C. Santos; Catarina A. Custódio; José Paulo S. Farinha; Carlos Baleizão; João F. Mano
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Hydrogels as Delivery Systems for Spinal Cord Injury Regeneration Mater. Today Bio Pub Date : 2021-01-22 Deolinda Silva; Rui A. Sousa; António J. Salgado
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Biofabrication of a shape-stable auricular structure for the reconstruction of ear deformities Mater. Today Bio Pub Date : 2021-01-21 I.A. Otto; P.E. Capendale; J.P. Garcia; M. de Ruijter; R.F.M. van Doremalen; M. Castilho; T. Lawson; M.W. Grinstaff; C.C. Breugem; M. Kon; R. Levato; J. Malda
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Cellular reprogramming with multigene activation by the delivery of CRISPR/dCas9 ribonucleoproteins via magnetic peptide-imprinted chitosan nanoparticles Mater. Today Bio Pub Date : 2021-01-20 Mei-Hwa Lee; Cheng-Chih Lin; James L. Thomas; Jin-An Li; Hung-Yin Lin
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Bone tumor–targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells Mater. Today Bio Pub Date : 2020-12-07 R.A. Nadar; G.M. Franssen; N.W.M. Van Dijk; K. Codee-van der Schilden; M. de Weijert; E. Oosterwijk; M. Iafisco; N. Margiotta; S. Heskamp; J.J.J.P. van den Beucken; S.C.G. Leeuwenburgh
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Enzyme functionalized microgels enable precise regulation of dissolved oxygen and anaerobe culture Mater. Today Bio Pub Date : 2021-01-02 Ananthakrishnan Soundaram Jeevarathinam; Fengguang Guo; Tyrell Williams; Justin A. Smolen; Jenny A. Hyde; Michael J. McShane; Paul de Figueiredo; Daniel L. Alge
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Improved ionic-liquid-functionalized macroporous supports able to purify nucleic acids in one step Mater. Today Bio Pub Date : 2020-11-11 M.C. Neves; P. Pereira; A.Q. Pedro; J.C. Martins; T. Trindade; J.A. Queiroz; M.G. Freire; F. Sousa
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A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria Mater. Today Bio Pub Date : 2020-11-02 Robert Richter; Mohamed.A.M. Kamal; Mariel A. García-Rivera; Jerome Kaspar; Maximilian Junk; Walid A.M. Elgaher; Sanjay Kumar Srikakulam; Alexander Gress; Anja Beckmann; Alexander Grißmer; Carola Meier; Michael Vielhaber; Olga Kalinina; Anna K.H. Hirsch; Rolf W. Hartmann; Mark Brönstrup; Nicole Schneider-Daum; Claus-Michael Lehr
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A two-in-one Janus NIR-II AIEgen with balanced absorption and emission for image-guided precision surgery Mater. Today Bio Pub Date : 2020-12-03 Shunjie Liu; Yuanyuan Li; Jianquan Zhang; Haoke Zhang; Yong Wang; Clarence Chuah; Youhong Tang; Jacky W.Y. Lam; Ryan T.K. Kwok; Hanlin Ou; Dan Ding; Ben Zhong Tang
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Micro/nanoscale magnetic robots for biomedical applications Mater. Today Bio Pub Date : 2020-10-30 M. Koleoso; X. Feng; Y. Xue; Q. Li; T. Munshi; X. Chen
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Sustainable plant polyesters as substrates for optical gas sensors Mater. Today Bio Pub Date : 2020-10-20 R. Rodrigues; S.I.C.J. Palma; V. G. Correia; I. Padrão; J. Pais; M. Banza; C. Alves; J. Deuermeier; C. Martins; H.M.A. Costa; E. Ramou; C. Silva Pereira; A.C.A. Roque
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Low dose novel PARP-PI3K inhibition via nanoformulation improves colorectal cancer immunoradiotherapy Mater. Today Bio Pub Date : 2020-10-22 M.R. Landry; A.N. DuRoss; M.J. Neufeld; L. Hahn; G. Sahay; R. Luxenhofer; C. Sun
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A novel tropoelastin-based resorbable surgical mesh for pelvic organ prolapse repair Mater. Today Bio Pub Date : 2020-10-13 B. Aghaei-Ghareh-Bolagh; S. Mukherjee; K.M. Lockley; S.M. Mithieux; Z. Wang; S. Emmerson; S. Darzi; C.E. Gargett; A.S. Weiss
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Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties Mater. Today Bio Pub Date : 2020-09-30 M.A. Alobaid; S.-J. Richards; M.R. Alexander; M.I. Gibson; A.M. Ghaemmaghami
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Enzyme-mediated one-pot synthesis of hydrogel with the polyphenol cross-linker for skin regeneration Mater. Today Bio Pub Date : 2020-09-21 B.S. Kim; S.-H. Kim; K. Kim; Y.-H. An; K.-H. So; B.-G. Kim; N.S. Hwang
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Silk fibroin nanofibers: a promising ink additive for extrusion three-dimensional bioprinting Mater. Today Bio Pub Date : 2020-09-19 S. Sakai; A. Yoshii; S. Sakurai; K. Horii; O. Nagasuna
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Interfacial nanoarchitectonics for responsive cellular biosystems Mater. Today Bio Pub Date : 2020-09-11 Jingwen Song; Xiaofang Jia; Katsuhiko Ariga
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An open-source handheld extruder loaded with pore-forming bioink for in situ wound dressing Mater. Today Bio Pub Date : 2020-08-21 G. Ying; J. Manríquez; D. Wu; J. Zhang; N. Jiang; S. Maharjan; D.H. Hernández Medina; Y.S. Zhang
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Cancer-associated fibroblasts of the prostate promote a compliant and more invasive phenotype in benign prostate epithelial cells Mater. Today Bio Pub Date : 2020-08-17 A. Jaeschke; A. Jacobi; M.G. Lawrence; G.P. Risbridger; M. Frydenberg; E.D. Williams; I. Vela; D.W. Hutmacher; L.J. Bray; A. Taubenberger
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Blood-brain barrier amenable gold nanoparticles biofabrication in aged cell culture medium. Mater. Today Bio Pub Date : 2020-08-07 F U Rehman,J Bao,P Muhammad,W He,S Hanif,M A Rauf
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Engineering osteogenic microenvironments by combination of multilayers from collagen type I and chondroitin sulfate with novel cationic liposomes. Mater. Today Bio Pub Date : 2020-07-31 Y A Brito Barrera,G Hause,M Menzel,C E H Schmelzer,E Lehner,K Mäder,C Wölk,T Groth
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Tissue-in-a-Tube: three-dimensional in vitro tissue constructs with integrated multimodal environmental stimulation. Mater. Today Bio Pub Date : 2020-07-28 A Shahin-Shamsabadi,P R Selvaganapathy
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Non-covalent protein-based adhesives for transparent substrates-bovine serum albumin vs. recombinant spider silk. Mater. Today Bio Pub Date : 2020-07-10 A D Roberts,W Finnigan,P P Kelly,M Faulkner,R Breitling,E Takano,N S Scrutton,J J Blaker,S Hay
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Advances in biomaterials for skeletal muscle engineering and obstacles still to overcome. Mater. Today Bio Pub Date : 2020-07-09 M M Smoak,A G Mikos
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Mesenchymal stem cell exosomes in bone regenerative strategies-a systematic review of preclinical studies. Mater. Today Bio Pub Date : 2020-06-27 S H S Tan,J R Y Wong,S J Y Sim,C K E Tjio,K L Wong,J R J Chew,J H P Hui,W S Toh
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Comparative proteomic analysis of human mesenchymal stromal cell behavior on calcium phosphate ceramics with different osteoinductive potential. Mater. Today Bio Pub Date : 2020-06-24 Z Othman,R J C Mohren,B Cillero-Pastor,Z Shen,Y S N W Lacroix,A P M Guttenplan,Z Tahmasebi Birgani,L Eijssen,T M Luider,S van Rijt,P Habibovic
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Biodegradable, lignin-based encapsulation enables delivery of Trichoderma reesei with programmed enzymatic release against grapevine trunk diseases. Mater. Today Bio Pub Date : 2020-06-20 S Peil,S J Beckers,J Fischer,F R Wurm
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Nature-derived materials for the fabrication of functional biodevices. Mater. Today Bio Pub Date : 2020-06-12 S Pradhan,A K Brooks,V K Yadavalli
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Functionality-packed additively manufactured porous titanium implants. Mater. Today Bio Pub Date : 2020-06-03 I A J van Hengel,F S A Gelderman,S Athanasiadis,M Minneboo,H Weinans,A C Fluit,B C J van der Eerden,L E Fratila-Apachitei,I Apachitei,A A Zadpoor
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Local injection of a hexametaphosphate formulation reduces heterotopic ossification in vivo. Mater. Today Bio Pub Date : 2020-06-02 T E Robinson,N M Eisenstein,S C Cox,R J A Moakes,A M Thompson,Z Ahmed,E A B Hughes,L J Hill,S A Stapley,L M Grover
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Tissue mimetic hyaluronan bioink containing collagen fibers with controlled orientation modulating cell migration and alignment. Mater. Today Bio Pub Date : 2020-06-01 A Schwab,C Hélary,R G Richards,M Alini,D Eglin,M D'Este
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Porcine mesothelium matrix as a biomaterial for wound healing applications. Mater. Today Bio Pub Date : 2020-05-17 H Capella-Monsonís,M A Tilbury,J G Wall,D I Zeugolis
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Rational design and latest advances of codelivery systems for cancer therapy. Mater. Today Bio Pub Date : 2020-05-07 Q Y Meng,H L Cong,H Hu,F-J Xu
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Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis. Mater. Today Bio Pub Date : 2020-05-04 G Y Wang,S L Rayner,R Chung,B Y Shi,X J Liang
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A melt-electrowritten filter for capture and culture of circulating colon cancer cells. Mater. Today Bio Pub Date : 2020-05-01 M L Jørgensen,C Müller,M Sikkersoq,M Nadzieja,Z Zhang,Y Su,J Just,K-L Garm Spindler,M Chen
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Wholly vascularized millimeter-sized engineered tissues by cell-sized microscaffolds. Mater. Today Bio Pub Date : 2020-04-28 Y Naka,S Kitano,S Irie,M Matsusaki
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Miniaturized high-throughput synthesis and screening of responsive hydrogels using nanoliter compartments. Mater. Today Bio Pub Date : 2020-04-18 Alisa Rosenfeld,Claude Oelschlaeger,Richard Thelen,Stefan Heissler,Pavel A Levkin
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Additive manufactured, highly resilient, elastic, and biodegradable poly(ester)urethane scaffolds with chondroinductive properties for cartilage tissue engineering. Mater. Today Bio Pub Date : 2020-04-13 S Camarero-Espinosa,C Tomasina,A Calore,L Moroni
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Repeated exposure to aerosolized graphene oxide mediates autophagy inhibition and inflammation in a three-dimensional human airway model. Mater. Today Bio Pub Date : 2020-03-24 L Di Cristo,B Grimaldi,T Catelani,E Vázquez,P P Pompa,S Sabella
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Enzymatic outside-in cross-linking enables single-step microcapsule production for high-throughput three-dimensional cell microaggregate formation. Mater. Today Bio Pub Date : 2020-03-06 B van Loo,S S Salehi,S Henke,A Shamloo,T Kamperman,M Karperien,J Leijten
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Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels. Mater. Today Bio Pub Date : 2020-02-27 R Kadri,J Bacharouch,K Elkhoury,G Ben Messaoud,C Kahn,S Desobry,M Linder,A Tamayol,G Francius,J F Mano,L Sánchez-González,E Arab-Tehrany
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Functionalized DNA-spider silk nanohydrogels for controlled protein binding and release. Mater. Today Bio Pub Date : 2020-02-24 Martin Humenik,Tamara Preiß,Sebastian Gödrich,Georg Papastavrou,Thomas Scheibel
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Nanoscale dynamic chemical, biological sensor material designs for control monitoring and early detection of advanced diseases Mater. Today Bio Pub Date : 2020-02-14 S.A. El-Safty, M.A. Shenashen
Early detection and easy continuous monitoring of emerging or re-emerging infectious, contagious or other diseases are of particular interest for controlling healthcare advances and developing effective medical treatments to reduce the high global cost burden of diseases in the backdrop of lack of awareness regarding advancing diseases. Under an ever-increasing demand for biosensor design reliability
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Biofabrication for neural tissue engineering applications. Mater. Today Bio Pub Date : 2020-01-30 L Papadimitriou,P Manganas,A Ranella,E Stratakis
Unlike other tissue types, the nervous tissue extends to a wide and complex environment that provides a plurality of different biochemical and topological stimuli, which in turn defines the advanced functions of that tissue. As a consequence of such complexity, the traditional transplantation therapeutic methods are quite ineffective; therefore, the restoration of peripheral and central nervous system
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Nerve guidance conduit design based on self-rolling tubes Mater. Today Bio Pub Date : 2020-01-27 T.B. Aigner, C. Haynl, S. Salehi, A. O'Connor, T. Scheibel
The current gold standard in peripheral nerve repair is nerve autografts for bridging gaps larger than a centimeter. However, autografts are associated with a low availability and the loss of function at the donor site. Nerve guidance conduits (NGCs) made of biocompatible and biodegradable materials reflect suitable alternatives. Clinically approved NGCs comprise either wraps that are rolled around
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Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities Mater. Today Bio Pub Date : 2020-01-09 Kai Zheng, Elisa Torre, Alessandra Bari, Nicola Taccardi, Clara Cassinelli, Marco Morra, Sonia Fiorilli, Chiara Vitale-Brovarone, Giorgio Iviglia, Aldo R. Boccaccini
Mesoporous bioactive glass nanoparticles (MBGNs) are emerging biomaterials for bone repair/regeneration, considering their favorable pro-osteogenic and proangiogenic activities. To further improve their therapeutic effects, the endowment of MBGNs with additional antioxidant properties is of particular interest to target oxidative stress related to bone remodeling and diseases. To this end, we developed
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A worm gel-based 3D model to elucidate the paracrine interaction between multiple myeloma and mesenchymal stem cells Mater. Today Bio Pub Date : 2020-01-07 Renza Spelat, Federico Ferro, Paolo Contessotto, Nicholas J. Warren, Grazia Marsico, Steven P. Armes, Abhay Pandit
Multiple myeloma (MM) is a malignancy of terminally-differentiated plasma cells that develops mainly inside the bone marrow (BM) microenvironment. It is well known that autocrine and paracrine signals are responsible for the progression of this disease but the precise mechanism and contributions from single cell remain largely unknown. Mesenchymal stem cells (MSC) are an important cellular component
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The molecular structure and multifunctionality of the cryptic plant polymer suberin Mater. Today Bio Pub Date : 2019-12-26 V.G. Correia, A. Bento, J. Pais, R. Rodrigues, Ł.P. Haliński, M. Frydrych, A. Greenhalgh, P. Stepnowski, F. Vollrath, A.W.T. King, C. Silva Pereira
Suberin, a plant polyester, consists of polyfunctional long-chain fatty acids and glycerol and is an intriguing candidate as a novel antimicrobial material. We purified suberin from cork using ionic-liquid catalysis during which the glycerol bonds that ensure the polymeric nature of suberin remained intact or were only partially cleaved—yielding the closest to a native configuration reported to date
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Materials and manufacturing perspectives in engineering heart valves: a review Mater. Today Bio Pub Date : 2019-12-05 F. Oveissi, S. Naficy, A. Lee, D.S. Winlaw, F. Dehghani
Valvular heart diseases (VHD) are a major health burden, affecting millions of people worldwide. The treatments for such diseases rely on medicine, valve repair, and artificial heart valves including mechanical and bioprosthetic valves. Yet, there are countless reports on possible alternatives noting long-term stability and biocompatibility issues and highlighting the need for fabrication of more durable
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Multifunctional phototheranostic nanomedicine for cancer imaging and treatment Mater. Today Bio Pub Date : 2019-11-06 D. Gao, X. Guo, X. Zhang, S. Chen, Y. Wang, T. Chen, G. Huang, Y. Gao, Z. Tian, Z. Yang
Cancer, as one of the most life-threatening diseases, shows a high fatality rate around the world. When improving the therapeutic efficacy of conventional cancer treatments, researchers also conduct extensive studies into alternative therapeutic approaches, which are safe, valid, and economical. Phototherapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), are tumor-ablative
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Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells Mater. Today Bio Pub Date : 2019-10-25 H. Li, X. Li, Y. Wang, J. Ji
To overcome the dilemma between passive tissue targeting and active cell targeting, nanomaterials are often required to exhibit the transition from ‘stealth’ to ‘active targetable’ in response to the pathological microenvironment. Here, we introduced a ternary surface modification method that incorporating active targeting ligand lactobionic acid with pH-sensitive mixed-charge surface. The resulted
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Ceramics with the signature of wood: a mechanical insight Mater. Today Bio Pub Date : 2019-10-24 D. Bigoni, R. Cavuoto, D. Misseroni, M. Paggi, A. Ruffini, S. Sprio, A. Tampieri
In an attempt to mimic the outstanding mechanical properties of wood and bone, a 3D heterogeneous chemistry approach has been used in a biomorphic transformation process (in which sintering is avoided) to fabricate ceramics from rattan wood, preserving its hierarchical fibrous microstructure. The resulting material (called biomorphic apatite [BA] henceforth) possesses a highly bioactive composition
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Janus particles: design, preparation, and biomedical applications Mater. Today Bio Pub Date : 2019-10-21 H. Su, C.-A. Hurd Price, L. Jing, Q. Tian, J. Liu, K. Qian
Janus particles with an anisotropic structure have emerged as a focus of intensive research due to their diverse composition and surface chemistry, which show excellent performance in various fields, especially in biomedical applications. In this review, we briefly introduce the structures, composition, and properties of Janus particles, followed by a summary of their biomedical applications. Then
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Honeycomb blocks composed of carbonate apatite, β-tricalcium phosphate, and hydroxyapatite for bone regeneration: effects of composition on biological responses Mater. Today Bio Pub Date : 2019-09-24 K. Hayashi, R. Kishida, A. Tsuchiya, K. Ishikawa
Synthetic scaffolds exhibiting bone repair ability equal to that of autogenous bone are required in the fields of orthopedics and dentistry. A suitable synthetic bone graft substitute should induce osteogenic differentiation of mesenchymal stem cells, osteogenesis, and angiogenesis. In this study, three types of honeycomb blocks (HCBs), composed of hydroxyapatite (HAp), β-tricalcium phosphate (TCP)
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Effect of peristaltic-like movement on bioengineered intestinal tube Mater. Today Bio Pub Date : 2019-09-19 S. Sibilio, V. De Gregorio, F. Urciuolo, P.A. Netti, G. Imparato
The intestine is a highly heterogeneous hollow organ with biological, mechanical and chemical differences between lumen and wall. A functional human intestine model able to recreate the in vivo dynamic nature as well as the native tissue morphology is demanded for disease research and drug discovery. Here, we present a system, which combines an engineered three-dimensional (3D) tubular-shaped intestine
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Printing bone in a gel: using nanocomposite bioink to print functionalised bone scaffolds. Mater. Today Bio Pub Date : 2019-09-16 G Cidonio,M Cooke,M Glinka,J I Dawson,L Grover,R O C Oreffo
Free-form printing offers a novel biofabrication approach to generate complex shapes by depositing hydrogel materials within a temporary supportive environment. However, printed hydrogels typically lack the requisite mechanical properties and functionality of the desired tissue, limiting application and, more importantly, safety and efficacy of the implant. The study authors have developed an innovative
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Biological activity of laminin/polylaminin-coated poly-ℇ-caprolactone filaments on the regeneration and tissue replacement of the rat sciatic nerve Mater. Today Bio Pub Date : 2019-08-21 R. de Siqueira-Santos, G. Sardella-Silva, M.A. Nascimento, L. Teixeira de Oliveira, T. Coelho-Sampaio, V.T. Ribeiro-Resende
Unlike the central nervous system, peripheral nerves can regenerate after injury. However, depending on the size of the lesion, the endogenous regenerative potential is not enough to replace the lost nerve tissue. Many strategies have been used to generate biomaterials capable of restoring nerve functions. Here, we set out to investigate whether adsorbing the extracellular matrix protein, laminin (LM)
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Shape-defined solid micro-objects from poly(d,l-lactic acid) as cell-supportive counterparts in bottom-up tissue engineering Mater. Today Bio Pub Date : 2019-08-20 A.M. Leferink, M.P. Tibbe, E.G.B.M. Bossink, L.E. de Heus, H. van Vossen, A. van den Berg, L. Moroni, R.K. Truckenmüller
In bottom-up tissue engineering, small modular units of cells and biomaterials are assembled toward larger and more complex ones. In conjunction with a new implementation of this approach, a novel method to fabricate microscale objects from biopolymers by thermal imprinting on water-soluble sacrificial layers is presented. By this means, geometrically well-defined objects could be obtained without
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Solid-phase combinatorial synthesis using microarrays of microcompartments with light-induced on-chip cell screening Mater. Today Bio Pub Date : 2019-08-20 A. Rosenfeld, M. Brehm, A. Welle, V. Trouillet, S. Heissler, M. Benz, P.A. Levkin
The process of drug discovery includes individual synthesis and characterization of drug candidates, followed by a biological screening, which is separated from synthesis in space and time. This approach suffers from low throughput and associated high costs, which in turn lead to inefficiency in the field of drug discovery. Here, we present a miniaturized platform combining combinatorial solid-phase
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Three-dimensional printing of metals for biomedical applications Mater. Today Bio Pub Date : 2019-08-20 J. Ni, H. Ling, S. Zhang, Z. Wang, Z. Peng, C. Benyshek, R. Zan, A.K. Miri, Z. Li, X. Zhang, J. Lee, K.-J. Lee, H.-J. Kim, P. Tebon, T. Hoffman, M.R. Dokmeci, N. Ashammakhi, X. Li, A. Khademhosseini
Three-dimensional (3D) printing technology has received great attention in the past decades in both academia and industry because of its advantages such as customized fabrication, low manufacturing cost, unprecedented capability for complex geometry, and short fabrication period. 3D printing of metals with controllable structures represents a state-of-the-art technology that enables the development
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