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Stepwise degradable PGA-SF core-shell electrospinning scaffold with superior tenacious in wetting regime for promoting bone regeneration Mater. Today Bio (IF 8.2) Pub Date : 2024-03-12 Yuan Zhang, Yutao Jian, Xiao Jiang, Xuerong Li, Xiangnan Wu, Juan Zhong, Xiaoshi Jia, Qiulan Li, Xiaodong Wang, Ke Zhao, Yitong Yao
Regenerating bone in the oral and maxillofacial region is clinically challenging due to the complicated osteogenic environment and the limitation of existing bone graft materials. Constructing bone graft materials with controlled degradation and stable mechanical properties in a physiological environment is of utmost importance. In this study, we used silk fibroin (SF) and polyglycolic acid (PGA) to
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A review on gold nanoparticles as an innovative therapeutic cue in bone tissue engineering: Prospects and future clinical applications Mater. Today Bio (IF 8.2) Pub Date : 2024-03-12 Dae Hyeok Yang, Haram Nah, Donghyun Lee, Sung Jun Min, Seulki Park, Sang-Hyun An, Jianxin Wang, Huining He, Kyu-Sun Choi, Wan-Kyu Ko, Jae Seo Lee, Il Keun Kwon, Sang Jin Lee, Dong Nyoung Heo
Bone damage is a complex orthopedic problem primarily caused by trauma, cancer, or bacterial infection of bone tissue. Clinical care management for bone damage remains a significant clinical challenge and there is a growing need for more advanced bone therapy options. Nanotechnology has been widely explored in the field of orthopedic therapy for the treatment of a severe bone disease. Among nanomaterials
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Bioactive coating provides antimicrobial protection through immunomodulation and phage therapeutics Mater. Today Bio (IF 8.2) Pub Date : 2024-03-11 Kenny Zhuoran Wu, Zhicheng Le, Ba Myint, Brian Chan, Ling Liu, Hua Huang, Swee Leong Sing, Andy Tay
Medical implant-associated infections (IAI) is a growing threat to patients undergoing implantation surgery. IAI prevention typically relies on medical implants endowed with bactericidal properties achieved through surface modifications with antibiotics. However, the clinical efficacy of this traditional paradigm remains suboptimal, often necessitating revision surgery and posing potentially lethal
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Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy Mater. Today Bio (IF 8.2) Pub Date : 2024-03-11 Yingcai Meng, Jiaxin Huang, Jinsong Ding, Haiyan Zhou, Yong Li, Wenhu Zhou
The cGAS-STING pathway holds tremendous potential as a regulator of immune responses, offering a means to reshape the tumor microenvironment and enhance tumor immunotherapy. Despite the emergence of STING agonists, their clinical viability is hampered by stability and delivery challenges, as well as variations in STING expression within tumors. In this study, we present Mn-phenolic networks as a novel
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MRI-guided cell membrane-camouflaged bimetallic coordination nanoplatform for combined tumor phototherapy Mater. Today Bio (IF 8.2) Pub Date : 2024-03-11 Mengyang Zhou, Yifei Wang, Yaning Xia, Yinhua Li, Jianfeng Bao, Yong Zhang, Jingliang Cheng, Yupeng Shi
Nanotechnology for tumor diagnosis and optical therapy has attracted widespread interest due to its low toxicity and convenience but is severely limited due to uncontrollable tumor targeting. In this work, homologous cancer cell membrane-camouflaged multifunctional hybrid metal coordination nanoparticles (DRu/Gd@CM) were prepared for MRI-guided photodynamic therapy (PDT) and photothermal therapy (PTT)
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Primary adipocytes as targetable drug depot to prevent post-surgical cancer recurrence Mater. Today Bio (IF 8.2) Pub Date : 2024-03-07 Yang Bo, Yueji Wang, Joonsu Han, Rimsha Bhatta, Yusheng Liu, Dhyanesh Baskaran, Jiadiao Zhou, Hua Wang
Surgery followed by adjuvant chemotherapy or radiation therapy remains the mainstream treatment for breast cancer in the clinic. However, cancer recurrence post surgery is still common. In view of the clinical practice that autologous fat tissue grafting is often used to facilitate breast reconstruction after lumpectomy, here we develop an targetable adipocyte-based drug depot for the prevention of
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Light-sensitive PEG hydrogel with antibacterial performance for pacemaker pocket infection prevention Mater. Today Bio (IF 8.2) Pub Date : 2024-03-07 Yurong Xiong, Qingyun Zhang, Juan Li, Nan Zhang, Xiaoshu Cheng, Quanbin Dong, Huihui Bao
Prevention of cardiovascular implantable electronic devices (CIED) infection is crucial for successful outcomes. In this study, we report an adhesive and antibacterial hydrogel coating for CIED infection treatment, by immobilizing polyethylene glycol (PEG) and 2′--hydroxypropyl trimethyl ammonium chloride chitosan (HAC) on Ti surface. Initial alkali and APTES treatment caused the formation of –NH to
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Immobilizing c(RGDfc) on the surface of metal-phenolic networks by thiol-click reaction for accelerating osteointegration of implant Mater. Today Bio (IF 8.2) Pub Date : 2024-03-03 Zeyu Shou, Zhibiao Bai, Kaiyuan Huo, Shengwu Zheng, Yizhe Shen, Han Zhou, Xiaojing Huang, Hongming Meng, Chenwei Xu, Shaohao Wu, Na Li, Chun Chen
The limited osteointegration often leads to the failure of implant, which can be improved by fixing bioactive molecules onto the surface, such as arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. Metal-Phenolic Networks (MPNs) have garnered increasing attention from different disciplines in recent years due to their simple and rapid process for depositing on various substrates or particles
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What else should hemostatic materials do beyond hemostasis: A review Mater. Today Bio (IF 8.2) Pub Date : 2024-03-02 Xinran Yang, Xiudan Wang, Xing Gao, Xiaoqin Guo, Shike Hou, Jie Shi, Qi Lv
Massive blood loss due to injury is the leading cause of prehospital deaths in disasters and emergencies. Hemostatic materials are used to realize rapid hemostasis and protect patients from death. Researchers have designed and developed a variety of hemostatic materials. However, in addition to their hemostatic effect, hemostatic materials must be endowed with additional functions to meet the practical
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From static to dynamic: The influence of mechanotransduction on skin equivalents analyzed by bioimaging and RNAseq Mater. Today Bio (IF 8.2) Pub Date : 2024-03-02 Katharina Kaiser, Sofie M. Bendixen, Jens Ahm Sørensen, Jonathan R. Brewer
In this study, we explore the impact of mechanical stimuli on skin models using an innovative skin-on-a-chip platform, addressing the limitations of conventional transwell-cultured skin equivalents. This platform facilitates cyclic mechanical stimulation through compression and stretching, combined with automated media perfusion. Our findings, using bioimaging and bulk RNA sequencing, reveal increased
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Cell sheet formation enhances the therapeutic effects of adipose-derived stromal vascular fraction on urethral stricture Mater. Today Bio (IF 8.2) Pub Date : 2024-02-29 Muxin Li, Tianli Yang, Jun Zhao, Xinghua Ma, Yuanyuan Cao, Xiaojie Hu, Shuli Zhao, Liuhua Zhou
Urethral stricture (US) is a common disease in urology, lacking effective treatment options. Although injecting a stem cells suspension into the affected area has shown therapeutic benefits, challenges such as low retention rate and limited efficacy hinder the clinical application of stem cells. This study evaluates the therapeutic impact and the mechanism of adipose-derived vascular fraction (SVF)
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AI energized hydrogel design, optimization and application in biomedicine Mater. Today Bio (IF 8.2) Pub Date : 2024-02-29 Zuhao Li, Peiran Song, Guangfeng Li, Yafei Han, Xiaoxiang Ren, Long Bai, Jiacan Su
Traditional hydrogel design and optimization methods usually rely on repeated experiments, which is time-consuming and expensive, resulting in a slow-moving of advanced hydrogel development. With the rapid development of artificial intelligence (AI) technology and increasing material data, AI-energized design and optimization of hydrogels for biomedical applications has emerged as a revolutionary breakthrough
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The microalga Volvox carteri as a cell supportive building block for tissue engineering Mater. Today Bio (IF 8.2) Pub Date : 2024-02-29 Mathilde Stricher, Pascale Vigneron, Frederic Delbecq, Claude-Olivier Sarde, Christophe Egles
constitutes, in its most simplified form, a cellularized spheroid built around and stabilised by a form of primitive extracellular matrix (ECM). We developed a modular approach to soft tissue engineering, by compact stacking V. -based building blocks. This approach is made possible by the structure and cell adhesive properties of these building blocks, which results from the composition of their algal
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Cascaded controlled delivering growth factors to build vascularized and osteogenic microenvironment for bone regeneration Mater. Today Bio (IF 8.2) Pub Date : 2024-02-29 Haifei Cao, Shuangjun He, Mingzhou Wu, Lihui Hong, Xiaoxiao Feng, Xuzhu Gao, Hongye Li, Mingming Liu, Nanning Lv
The process of bone regeneration is intricately regulated by various cytokines at distinct stages. The establishment of early and efficient vascularization, along with the maintenance of a sustained osteoinductive microenvironment, plays a crucial role in the successful utilization of bone repair materials. This study aimed to develop a composite hydrogel that would facilitate the creation of an osteogenic
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Biomimetic fabrication of sr-silk fibroin co-assembly hydroxyapatite based microspheres with angiogenic and osteogenic properties for bone tissue engineering Mater. Today Bio (IF 8.2) Pub Date : 2024-02-27 Yunfei Liu, Chengji Shi, Piaoye Ming, Lingling Yuan, Xueyu Jiang, Min Jiang, Rui Cai, Xiaorong Lan, Jingang Xiao, Gang Tao
Bone defects caused by trauma, tumor resection, or developmental abnormalities are important issues in clinical practice. The vigorous development of tissue engineering technology provides new ideas and directions for regenerating bone defects. Hydroxyapatite (HAp), a bioactive ceramic, is extensively used in bone tissue engineering because of its excellent osteoinductive performance. However, its
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Liposome encapsulated polydopamine nanoparticles: Enhancing ferroptosis and activating hypoxia prodrug activity Mater. Today Bio (IF 8.2) Pub Date : 2024-02-25 Yijun Guo, Huiling Luo, Hairong Jiang, Xinxin Liu, Xinrui Long, Yinuo Hou, Zhou Chen, Yanan Sun, Dongtao Ge, Wei Shi
The short lifespan of active oxygen species and depressed O level during ferroptosis treatment in tumor cells weaken ferroptosis therapy. How to improve the utilization efficiency of active oxygen species generated in real time is pivotal for anticancer treatment. Herein, the tirapazamine (TPZ) loaded polydopamine-Fe nanoparticles (PDA-Fe-TPZ) was modified with unsaturated liposome (Lip), which was
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Injectable nanocomposite hydrogels with enhanced lubrication and antioxidant properties for the treatment of osteoarthritis Mater. Today Bio (IF 8.2) Pub Date : 2024-02-22 Qizhu Chen, Yuxin Jin, Tao Chen, Hao Zhou, Xinzhou Wang, Ouqiang Wu, Linjie Chen, Zhiguang Zhang, Zhengyu Guo, Jin Sun, Aimin Wu, Qiuping Qian
Osteoarthritis (OA) is a chronic inflammatory joint disease characterized by progressive cartilage degeneration, synovitis, and osteoid formation. In order to effectively treat OA, it is important to block the harmful feedback caused by reactive oxygen species (ROS) produced during joint wear. To address this challenge, we have developed injectable nanocomposite hydrogels composed of polygallate-Mn
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Fabrication of bioengineered corneal endothelial grafts using an allogeneic cornea-derived matrix Mater. Today Bio (IF 8.2) Pub Date : 2024-02-22 Lijie Xie, Xiaojuan Dong, Jianping Ji, Chen Ouyang, Jing Wu, Chao Hou, Ting Huang
Corneal endothelial keratoplasty has been the primary treatment method of endothelial decompensation, but it is often limited in clinical practice due to global shortage of donor cornea. Here, we explored using an ultra-thin allogeneic cornea-derived matrix (uACM) films as a substrate for constructing bioengineered corneal endothelial grafts. We evaluated the films' optical, mechanical, and structural
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Cellular response of advanced triple cultures of human osteocytes, osteoblasts and osteoclasts to high sulfated hyaluronan (sHA3) Mater. Today Bio (IF 8.2) Pub Date : 2024-02-22 Katharina Wirsig, Jana Bacova, Richard F. Richter, Vera Hintze, Anne Bernhardt
Bone remodelling, important for homeostasis and regeneration involves the controlled action of osteoblasts, osteocytes and osteoclasts. The present study established a three-dimensional human bone model as triple culture with simultaneously differentiating osteocytes and osteoclasts, in the presence of osteoblasts. Since high sulfated hyaluronan (sHA3) was reported as a biomaterial to enhance osteogenesis
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Mussel byssus-inspired dual-functionalization of zirconia dental implants for improved bone integration Mater. Today Bio (IF 8.2) Pub Date : 2024-02-22 Qihong Zhang, Shuyi Wu, Yingyue Sun, Kendrick Hii Ru Yie, Jiatong Zhuang, Tingting Liu, Wen Si, Yinyan Zhang, Zheyuan Liu, Lifeng Xiong, Lei Lu, Peng Gao, Jinsong Liu
Zirconia faces challenges in dental implant applications due to its inherent biological inertness, which compromises osseointegration, a critical factor for the long-term success of implants that rely heavily on specific cell adhesion and enhanced osteogenic activity. Here, we fabricated a dual-functional coating that incorporates strontium ions, aimed at enhancing osteogenic activity, along with an
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Oxygen-producing and pH-responsive targeted DNA nanoflowers for enhanced chemo-sonodynamic therapy of lung cancer Mater. Today Bio (IF 8.2) Pub Date : 2024-02-21 Hongjian Liao, Yuchao Cao, Can Hu, ShangFeng Shen, Zhifei Zhang, Dairong Li, Yonghong Du
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Assessing the functional potential of conditioned media derived from amniotic epithelial stem cells engineered on 3D biomimetic scaffolds: An in vitro model for tendon regeneration Mater. Today Bio (IF 8.2) Pub Date : 2024-02-18 Valentina Russo, Giuseppe Prencipe, Annunziata Mauro, Mohammad El Khatib, Arlette A. Haidar-Montes, Nico Cambise, Maura Turriani, Johannes Stöckl, Peter Steinberger, Loreto Lancia, Matthias Schnabelrauch, Paolo Berardinelli, Barbara Barboni
Tendon diseases pose a significant challenge in regenerative medicine due to the limited healing capacity of this tissue. Successful tendon regeneration requires a combination of angiogenesis, immune response, and tenogenesis processes. An effective tendon engineering (TE) strategy must finely tune this systems’ interplay toward homeostasis.
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Programming temporal stiffness cues within extracellular matrix hydrogels for modelling cancer niches Mater. Today Bio (IF 8.2) Pub Date : 2024-02-16 Gretel Major, Minjun Ahn, Won-Woo Cho, Miguel Santos, Jessika Wise, Elisabeth Phillips, Steven G. Wise, Jinah Jang, Jelena Rnjak-Kovacina, Tim Woodfield, Khoon S. Lim
Extracellular matrix (ECM) stiffening is a common occurrence during the progression of many diseases, such as breast cancer. To accurately mimic the pathophysiological context of disease within 3D models, there is high demand for smart biomaterials which replicate the dynamic and temporal mechanical cues of diseased states. This study describes a preclinical disease model, using breast cancer as an
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Mesoscale size-promoted targeted therapy for acute kidney injury through combined RONS scavenging and inflammation alleviation strategy Mater. Today Bio (IF 8.2) Pub Date : 2024-02-16 Xiaoqing Han, Luopeng Bi, Jiao Yan, Panpan Song, Yanjing Wang, Xinbo Wang, Yunyun Wu, Xiaobo Ding, Haiyuan Zhang, Yanbo Wang, Xi Li
Acute kidney injury (AKI) is a heterogeneous, high-mortality clinical syndrome with diverse pathogenesis and prognosis, but it lacks the effective therapy clinically. Its pathogenesis is associated with production of reactive oxygen/nitrogen species and infiltration of inflammatory cells. To overcome these pathogenic factors and improve the therapeutic efficiency, we synthesized triptolide-loaded mesoscale
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Niclosamide - encapsulated lipid nanoparticles for the reversal of pulmonary fibrosis Mater. Today Bio (IF 8.2) Pub Date : 2024-02-16 Yan Yu, Hongyao Liu, Liping Yuan, Meng Pan, Zhongwu Bei, Tinghong Ye, Zhiyong Qian
Pulmonary fibrosis (PF) is a serious and progressive fibrotic interstitial lung disease that is possibly life-threatening and that is characterized by fibroblast accumulation and collagen deposition. Nintedanib and pirfenidone are currently the only two FDA-approved oral medicines for PF. Some drugs such as antihelminthic drug niclosamide (Ncl) have shown promising therapeutic potentials for PF treatment
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3D bioprinting of liver models: A systematic scoping review of methods, bioinks, and reporting quality Mater. Today Bio (IF 8.2) Pub Date : 2024-02-15 Ahmed S.M. Ali, Dongwei Wu, Alexandra Bannach-Brown, Diyal Dhamrait, Johanna Berg, Beatrice Tolksdorf, Dajana Lichtenstein, Corinna Dressler, Albert Braeuning, Jens Kurreck, Maren Hülsemann
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Multifunctional nanomaterials via cell cuproptosis and oxidative stress for treating osteosarcoma and OS-induced bone destruction Mater. Today Bio (IF 8.2) Pub Date : 2024-02-15 Lin Ye, Congcong Yu, Jiechao Xia, Kainan Ni, Yejin Zhang, Xiaozhang Ying, Dingqi Xie, Yang Jin, Rongtai Sun, Ruikang Tang, Shunwu Fan, Shasha Yao
Reactive Oxygen Species (ROS) refers to a highly reactive class of oxidizing species that have the potential to induce cellular apoptosis and necrosis. Cuproptosis, a type of cell death, is primarily associated with the effects of copper ions. However, the specific relationship between ROS, cuproptosis, and osteosarcoma (OS) remains relatively unexplored. Additionally, there is limited research on
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Recognition of sounds by ensembles of proteinoids Mater. Today Bio (IF 8.2) Pub Date : 2024-02-13 Panagiotis Mougkogiannis, Andrew Adamatzky
Proteinoids are artificial polymers that imitate certain characteristics of natural proteins, including self–organization, catalytic activity, and responsiveness to external stimuli. This paper examines the acoustic response properties of proteinoids microspheres when exposed to auditory stimuli. We convert sounds of English alphabet into waveforms of electrical potential, feed the waveforms into proteinoid
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Hydrogel-based cardiac repair and regeneration function in the treatment of myocardial infarction Mater. Today Bio (IF 8.2) Pub Date : 2024-02-13 Qiaxin Xu, Zeyu Xiao, Qianzhi Yang, Tingting Yu, Xiujiao Deng, Nenghua Chen, Yanyu Huang, Lihong Wang, Jun Guo, Jinghao Wang
A life-threatening illness that poses a serious threat to human health is myocardial infarction. It may result in a significant number of myocardial cells dying, dilated left ventricles, dysfunctional heart function, and ultimately cardiac failure. Based on the development of emerging biomaterials and the lack of clinical treatment methods and cardiac donors for myocardial infarction, hydrogels with
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Ferritin-nanocaged aggregation-induced emission nanoaggregates for NIR-II fluorescence-guided noninvasive, controllable male contraception Mater. Today Bio (IF 8.2) Pub Date : 2024-02-13 Xinghua Yu, Jiaxue Shuai, Ge Meng, Shumin Zhou, Amali Upekshika Wijayaraja, Yixiang Zhao, Lei Yao, Rui Yao, Xing Yang, Tianfu Zhang, Liying Wang, Pengyu Gu, Pengfei Zhang, Fei Sun
Controllable contraception in male animals was demonstrated through the utilization of gold nanorods' photothermal effect to accomplish mild testicular hyperthermia. However, the challenges arising from testicular administration and the non-biodegradability of nanoparticles hinder further clinical implementation. Therefore, a straightforward, non-invasive, and enhanced contraception approach is required
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Cubosome-carrying bacterial cellulose membrane as a versatile drug delivery platform Mater. Today Bio (IF 8.2) Pub Date : 2024-02-13 Denise Gradella Villalva, Caio Gomide Otoni, Watson Loh
Using advanced nanotechnology membranes has opened up new possibilities in the field of biomedicine, particularly for controlled drug delivery and especially for topical use. Bacterial cellulose membranes (BCM), in particular, have gained prominence owing to their distinctive attributes, including remarkable water retention, safety, biodegradability, and tunable gas exchange. However, they are aqueous
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Viridibacillus culture derived silver nanoparticles exert potent anticancer action in 2D and 3D models of lung cancer via mitochondrial depolarization-mediated apoptosis Mater. Today Bio (IF 8.2) Pub Date : 2024-02-11 Abhayraj S. Joshi, Mugdha V. Bapat, Priyanka Singh, Ivan Mijakovic
Lung cancer is one of the most commonly occurring cancer types that accounts for almost 2 million cases per year. Its resistance to anticancer drugs, failure of new molecules in clinical trials, severe side-effects of current treatments, and its recurrence limit the success of anticancer therapies. Nanotherapeutic agents offer several advantages over conventional anticancer therapies, including improved
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“In-situ” formation of elastin-like recombinamer hydrogels with tunable viscoelasticity through efficient one-pot process Mater. Today Bio (IF 8.2) Pub Date : 2024-02-10 M. Hamed Misbah, Luis Quintanilla-Sierra, Matilde Alonso, José Carlos Rodríguez-Cabello, Mercedes Santos
Despite the remarkable progress in the generation of recombinant elastin-like (ELR) hydrogels, further improvements are still required to enhance and control their viscoelasticity, as well as limit the use of expensive chemical reagents, time-consuming processes and several purification steps. To alleviate this issue, the reactivity of carboxylic groups from glutamic (E) acid distributed along the
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Multi-functional composite dressings with sustained release of MSC-SLP and anti-adhesion property for accelerating wound healing Mater. Today Bio (IF 8.2) Pub Date : 2024-02-10 Wu Duan, Haipeng Wang, Ziran Wang, Zhongjing Ren, Xinxin Li, Falian He, Shaomin Li, Yingchun Guan, Fuqiang Liu, Li Chen, Peng Yan, Xinguo Hou
Exudate management is of significant clinical value for the treatment of acute wound. Various wound dressings have been developed to restore the function of injured tissues and promote wound healing, but proper exploiting the healing factors inside exudate and achieving anti-adhesion wound care remains a challenge. Herein, we present a novel multi-functional composite dressing (MCD) by coupling supernatant
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Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels Mater. Today Bio (IF 8.2) Pub Date : 2024-02-10 Jiuping Wu, Wu Xue, Zhihe Yun, Qinyi Liu, Xinzhi Sun
In recent years, owing to the ongoing advancements in polymer materials, hydrogels have found increasing applications in the biomedical domain, notably in the realm of stimuli-responsive "smart" hydrogels. Nonetheless, conventional single-network stimuli-responsive "smart" hydrogels frequently exhibit deficiencies, including low mechanical strength, limited biocompatibility, and extended response times
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Multiphoton lithography with protein photoresists Mater. Today Bio (IF 8.2) Pub Date : 2024-02-10 Dmitry Sivun, Eljesa Murtezi, Tina Karimian, Kurt Hurab, Maryam Marefat, Elena Klimareva, Christoph Naderer, Boris Buchroithner, Thomas A. Klar, Georgii Gvindzhiliia, Andreas Horner, Jaroslaw Jacak
Recently, 2D/3D direct laser writing has attracted increased attention due to its broad applications ranging from biomedical engineering to aerospace. 3D nanolithography of water-soluble protein-based scaffolds have been envisioned to provide a variety of tunable properties. In this paper, we present a functional protein-based photoresist with tunable mechanical properties that is suitable for multiphoton
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Slow and steady wins the race: Fractionated near-infrared treatment empowered by graphene-enhanced 3D scaffolds for precision oncology Mater. Today Bio (IF 8.2) Pub Date : 2024-02-09 Giordano Perini, Valentina Palmieri, Andrea Papait, Alberto Augello, Daniela Fioretti, Sandra Iurescia, Monica Rinaldi, Elsa Vertua, Antonietta Silini, Riccardo Torelli, Angela Carlino, Teresa Musarra, Maurizio Sanguinetti, Ornella Parolini, Marco De Spirito, Massimiliano Papi
Surgically addressing tumors poses a challenge, requiring a tailored, multidisciplinary approach for each patient based on the unique aspects of their case. Innovative therapeutic regimens combined to reliable reconstructive methods can contribute to an extended patient's life expectancy. This study presents a detailed comparative investigation of near-infrared therapy protocols, examining the impact
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Durable protective efficiency provide by mRNA vaccines require robust immune memory to antigens and weak immune memory to lipid nanoparticles Mater. Today Bio (IF 8.2) Pub Date : 2024-02-09 Xueying Tang, Jiashuo Zhang, Dezhi Sui, Zihan Xu, Qiongfen Yang, Tianyu Wang, Xiaoya Li, Xinrong Liu, Yihui Deng, Yanzhi Song
The Pegylated lipids in lipid nanoparticle (LNPs) vaccines have been found to cause acute hypersensitivity reactions in recipients, and generate -LNPs immunity after repeated administration, thereby reducing vaccine effectiveness. To overcome these challenges, we developed a new type of LNPs vaccine (SAPC-LNPs) which was co-modified with sialic acid (SA) - lipid derivative and cleavable PEG - lipid
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Molecular insights into the proteomic composition of porcine treated dentin matrix Mater. Today Bio (IF 8.2) Pub Date : 2024-02-05 Xiya Zhang, Sha Zhou, Yuzhen Zhan, Ziyi Mei, Aizhuo Qian, Yu Yuan, Xiaonan Zhang, Tiwei Fu, Shiyong Ma, Jie Li
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Unraveling the assembloid: Real-time monitoring of dopaminergic neurites in an inter-organoid pathway connecting midbrain and striatal regions Mater. Today Bio (IF 8.2) Pub Date : 2024-02-05 Alp Ozgun, David J. Lomboni, Amy Aylsworth, Allison Macdonald, William A. Staines, Marzia Martina, Michael G. Schlossmacher, Joseph S. Tauskela, John Woulfe, Fabio Variola
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Nano-energy interference: A novel strategy for blunting tumor adaptation and metastasis Mater. Today Bio (IF 8.2) Pub Date : 2024-02-03 Fei Teng, Dong Fu, Chen-Cheng Shi, An Xiong, Meng-Xuan Yang, Chang Su, Ming Lei, Yi-Ou Cao, Xiao-Dong Shen, Yi Chen, Pu-Hua Wang, Shao-Qun Liu
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Melatonin-encapsuled silk fibroin electrospun nanofibers promote vascularized bone regeneration through regulation of osteogenesis-angiogenesis coupling Mater. Today Bio (IF 8.2) Pub Date : 2024-02-02 Lei Deng, Mingzhuang Hou, Nanning Lv, Quan Zhou, Xi Hua, Xiayu Hu, Xiaoyang Ge, Xuesong Zhu, Yong Xu, Huilin Yang, Xi Chen, Hao Liu, Fan He
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Immune regulation enhances osteogenesis and angiogenesis using an injectable thiolated hyaluronic acid hydrogel with lithium-doped nano-hydroxyapatite (Li-nHA) delivery for osteonecrosis Mater. Today Bio (IF 8.2) Pub Date : 2024-01-28 Yue Luo, Zhouyuan Yang, Xin Zhao, Donghai Li, Qianhao Li, Yang Wei, Luyao Wan, Meng Tian, Pengde Kang
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Macromolecular crowding in human tenocyte and skin fibroblast cultures: A comparative analysis Mater. Today Bio (IF 8.2) Pub Date : 2024-01-28 Adrian Djalali-Cuevas, Mandy Rettel, Frank Stein, Mikhail Savitski, Stephen Kearns, Jack Kelly, Manus Biggs, Ioannis Skoufos, Athina Tzora, Nikitas Prassinos, Nikolaos Diakakis, Dimitrios I. Zeugolis
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Cell-permeable bone morphogenetic protein 2 facilitates bone regeneration by promoting osteogenesis Mater. Today Bio (IF 8.2) Pub Date : 2024-02-01 Mingu Kang, Seokwon Lee, Jong-pil Seo, Eun-bee Lee, Daye Ahn, Jisoo Shin, Young-Ki Paik, Daewoong Jo
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Near-infrared light responsive gold nanoparticles coating endows polyetheretherketone with enhanced osseointegration and antibacterial properties Mater. Today Bio (IF 8.2) Pub Date : 2024-02-01 Xinxin Zhan, Jianglong Yan, Dong Xiang, Hao Tang, Lulu Cao, Yufeng Zheng, Hong Lin, Dandan Xia
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Au nanozyme-based multifunctional hydrogel for inflammation visible monitoring and treatment Mater. Today Bio (IF 8.2) Pub Date : 2024-01-26 Yunjing Jiang, Yuyu Cao, Jie Wu, Rongxian Bai, Shufan Wan, Lei Dai, Jiangtao Su, Hongmei Sun
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Photo-/thermo-responsive bioink for improved printability in extrusion-based bioprinting Mater. Today Bio (IF 8.2) Pub Date : 2024-01-26 Seo Hyung Moon, Tae Yoon Park, Hyung Joon Cha, Yun Jung Yang
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Hypoxia-triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancer Mater. Today Bio (IF 8.2) Pub Date : 2024-01-28 Yulong Liu, Kang Yang, Jun Wang, Yanzhang Tian, Bin Song, Ruiping Zhang
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Biomimetic nanomaterials in myocardial infarction treatment: Harnessing bionic strategies for advanced therapeutics Mater. Today Bio (IF 8.2) Pub Date : 2024-01-24 Tingting Yu, Qiaxin Xu, Xu Chen, Xiujiao Deng, Nenghua Chen, Man Teng Kou, Yanyu Huang, Jun Guo, Zeyu Xiao, Jinghao Wang
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Amino acid-based supramolecular chiral hydrogels promote osteogenesis of human dental pulp stem cells via the MAPK pathway Mater. Today Bio (IF 8.2) Pub Date : 2024-01-28 Peilun Li, Qiaoqiao Jin, Kangrui Zeng, Chenguang Niu, Qianyang Xie, Ting Dong, Zhengwei Huang, Xiaoqiu Dou, Chuanliang Feng
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Corrigendum to “Laponite for biomedical applications: An ophthalmological perspective” [Mater. Today Bio 24 (2024) 100935] Mater. Today Bio (IF 8.2) Pub Date : 2024-01-27 Maria J. Rodrigo, Maria J. Cardiel, Jose M. Fraile, Jose A. Mayoral, Luis E. Pablo, Elena Garcia-Martin
Abstract not available
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Design of dual peptide-conjugated hydrogels for proliferation and differentiation of human pluripotent stem cells Mater. Today Bio (IF 8.2) Pub Date : 2024-01-23 Tzu-Cheng Sung, Yen-Hung Chen, Ting Wang, Liu Qian, Wen-Hui Chao, Jun Liu, Jiandong Pang, Qing-Dong Ling, Henry Hsin-Chung Lee, Akon Higuchi
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Harnessing fine fibers in decellularized adipose-derived matrix for enhanced adipose regeneration Mater. Today Bio (IF 8.2) Pub Date : 2024-01-25 Jiayi Feng, Su Fu, Jie Luan
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Acellular embryoid body and hydroxybutyl chitosan composite hydrogels promote M2 macrophage polarization and accelerate diabetic cutaneous wound healing Mater. Today Bio (IF 8.2) Pub Date : 2024-01-26 Yue Zhang, Zheng-Hong Chen, Kun Zhao, Yu-Dong Mu, Kun-Long Li, Zhi-Min Yuan, Zhi-Gang Liu, Le Han, Wei-Dong Lü
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Injectable thermosensitive selenium-containing hydrogel as mesenchymal stem cell carrier to improve treatment efficiency in limb ischemia Mater. Today Bio (IF 8.2) Pub Date : 2024-01-20 Xuan Tian, Xin Yan, Nan Zang, Wu Duan, Tixiao Wang, Xiaoxun Li, Ling Ma, Li Chen, Jun Chen, Xinguo Hou
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Nanotexture and crystal phase regulation for synergistic enhancement in re-endothelialization on medical pure titanium surface Mater. Today Bio (IF 8.2) Pub Date : 2024-01-20 Jing Zhang, Kai Ren, Jingru Qiu, Baolan Chen, Weixun Duan, Jincheng Liu, Guiling Li, Donghai Li
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Dual-functional thermosensitive hydrogel for reducing infection and enhancing bone regeneration in infected bone defects Mater. Today Bio (IF 8.2) Pub Date : 2024-01-20 Yuhang Tian, Yutao Cui, Guangkai Ren, Yi Fan, Minghan Dou, Shaorong Li, Gan Wang, Yanbing Wang, Chuangang Peng, Dankai Wu
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Capturing cerium ions via hydrogel microspheres promotes vascularization for bone regeneration Mater. Today Bio (IF 8.2) Pub Date : 2024-01-24 Junlin Liu, Zhangzhe Zhou, Mingzhuang Hou, Xiaowei Xia, Yang Liu, Zhijian Zhao, Yubin Wu, Yaoge Deng, Yijian Zhang, Fan He, Yong Xu, Xuesong Zhu
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Mi-BMSCs alleviate inflammation and fibrosis in CCl4-and TAA-induced liver cirrhosis by inhibiting TGF-β/Smad signaling Mater. Today Bio (IF 8.2) Pub Date : 2024-01-24 Qing Shi, Yuhan Xia, Minmin Wu, Yating Pan, Shiyi Wu, Jiawei Lin, Yifan Kong, Zhijie Yu, Xingjie Zan, Pixu Liu, Jinglin Xia