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High phase resolution: Probing interactions in complex interfaces with sum frequency generation. Biointerphases (IF 2.1) Pub Date : 2023-09-01 Mary Jane Shultz,Patrick Bisson,Jing Wang,Joam Marmolejos,Rebecca G Davies,Emma Gubbins,Ziqing Xiong
An often-quoted statement attributed to Wolfgang Pauli is that God made the bulk, but the surface was invented by the devil. Although humorous, the statement really reflects frustration in developing a detailed picture of a surface. In the last several decades, that frustration has begun to abate with numerous techniques providing clues to interactions and reactions at surfaces. Often these techniques
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Using 1,8-cineole plasma with both pulsed and continuous depositions to modify commercially available wound dressing materials. Biointerphases (IF 2.1) Pub Date : 2023-09-01 Mia-Rose Kayaian,Morgan J Hawker
The current clinical standards for infected chronic wounds are oral and topical antibiotics. These strategies are problematic because antibiotic resistance can occur with prolonged use. As an alternative to clinical methods, essential oils show promise in preventing bacterial growth. Specifically, 1,8-cineole-an active component in eucalyptus oil-exhibits antifungal, anti-inflammatory, and antibacterial
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Per- and polyfluoroalkyl substances (PFAS) at the interface of biological and environmental systems. Biointerphases (IF 2.1) Pub Date : 2023-09-01 Onur Apul,Caitlin Howell,M Dilara Hatinoglu
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Elevating nucleic acid delivery via a stable anionic peptide-dextran ternary system. Biointerphases (IF 2.1) Pub Date : 2023-09-01 Alex Cheng,Ying Liu,Hai-Qing Song
Nucleic acid-based therapies hold promise for treating previously intractable diseases but require effective delivery vectors to protect the therapeutic agents and ensure efficient transfection. Cationic polymeric vectors are particularly notable for their adaptability, high transfection efficiency, and low cost, but their positive charge often attracts blood proteins, causing aggregation and reduced
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Development of corneal contact lens materials and current clinical application of contact lenses: A review. Biointerphases (IF 2.1) Pub Date : 2023-09-01 Weichen Yuan,Fangkun Zhao,Xiaoyu Liu,Jun Xu
Unlike conventional glasses, corneal contact lenses (CLs) can directly contact the surface of the tear film through the application of biopolymer materials, to achieve therapeutic and cosmetic purposes. Since the advent of polymethylmethacrylate, a material that has gained widespread use and attention, statistically, there are now more than 150 × 106 people around the world who wear corneal contact
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"Nonlinear" pursuit of understanding pollutant accumulation and chemistry at environmental and biological interfaces. Biointerphases (IF 2.1) Pub Date : 2023-09-01 Andrew P Carpenter,Thaddeus W Golbek
Over the past few decades, the public recognition of the prevalence of certain classes of pollutants, such as perfluoroalkyl substances and nanoplastics, within the environment, has sparked growing concerns over their potential impact on environmental and human health. Within both environmental and biological systems, the adsorption and structural organization of pollutants at aqueous interfaces can
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Management of per- and polyfluoroalkyl substances (PFAS)-laden wastewater sludge in Maine: Perspectives on a wicked problem. Biointerphases (IF 2.1) Pub Date : 2023-07-01 Simin Moavenzadeh Ghaznavi,Charity Zimmerman,Molly E Shea,Jean D MacRae,John M Peckenham,Caroline L Noblet,Onur G Apul,A Dianne Kopec
This article discusses the challenges and potential solutions for managing wastewater sludge that contains per- and polyfluoroalkyl substances (PFAS), using the experience in Maine as a guide toward addressing the issue nationally. Traditional wastewater treatment, designed to remove excess organic waste and nutrients, does not eliminate persistent toxic pollutants like PFAS, instead partitioning the
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Ultraflexible polyvinylidene fluoride film based amperometric enzyme-free sensor for selective detection of uric acid in a trace level. Biointerphases (IF 2.1) Pub Date : 2023-07-01 Abhisek Maikap,Riju Karmakar,Ajit Kumar Meikap,Subhra Samanta
The present invention describes a novel flexible nanosensor for the electrochemical detection of uric acid (UA) present in urine. The synthesized graphite-boron nanocomposite with an average thickness of ∼32 nm was grown up on a flexible polyvinylidene fluoride film with an average thickness of ∼50 μm and it acts as a nonenzymatic sensor for UA. The developed flexible sensor showed a prominent reduction
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Influence of titanium and zirconia substrates on the synthesis of inflammatory mediators. Biointerphases (IF 2.1) Pub Date : 2023-07-01 João Moura Neto,Lais Medeiros Cardoso,Taisa Nogueira Pansani,Larissa M S C Raucci,Carlos Alberto de Souza Costa,Fernanda G Basso
The repair and homeostasis of peri-implant tissues depend on several factors such as the local presence of pathogenic bacteria and their products. Among other events, peri-implant tissue response is also related to the implant material used, which interferes with cells and extracellular matrix interactions, affecting the osseointegration process. In this study, the influence of zirconia (Zr) and titanium
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Secondary ion mass spectrometry for bone research. Biointerphases (IF 2.1) Pub Date : 2023-07-01 Christine Kern,Stefanie Kern,Anja Henss,Marcus Rohnke
The purpose of this Tutorial is to highlight the suitability of time-of-flight secondary ion mass spectrometry (ToF-SIMS) and OrbiTrap™ SIMS (Orbi-SIMS) in bone research by introducing fundamentals and best practices of bone analysis with these mass spectrometric imaging (MSI) techniques. The Tutorial includes sample preparation, determination of best-suited measurement settings, data acquisition,
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PFAS (per- and polyfluoroalkyl substance)-free molded fiber: The future is already here. Biointerphases (IF 2.1) Pub Date : 2023-07-01 Mehdi Tajvidi
With renewed interest in food packaging materials that can be both recyclable and compostable and the environmental concerns about plastic pollution in the terrestrial and aquatic ecosystems, molded fiber food packaging is experiencing an unprecedented demand around the globe. However, the phase-out of per- and polyfluoroalkyl substances (PFASs), commonly used as a water/grease resistant agent in food
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Theoretical study of electronic sum frequency generation spectroscopy to assess the buried interfaces. Biointerphases (IF 2.1) Pub Date : 2023-07-01 Yogesh Kumar,Suman Dhami,Ravindra Pandey
This article provides a comprehensive theoretical background of electronic sum frequency generation (ESFG), a second-order nonlinear spectroscopy technique. ESFG is utilized to investigate both exposed and buried interfaces, which are challenging to study using conventional spectroscopic methods. By overlapping two incident beams at the interface, ESFG generates a beam at the sum of their frequencies
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Development of electronic sum frequency generation spectrophotometer to assess the buried interfaces. Biointerphases (IF 2.1) Pub Date : 2023-07-01 Suman Dhami,Yogesh Kumar,Ravindra Pandey
The interfacial region between two bulk media in organic semiconductor based devices, such as organic field-effect transistors (OFETs), organic light-emitting diodes, and organic photovoltaics, refers to the region where two different materials such as an organic material and an electrode come in contact with each other. Although the interfacial region contains a significantly smaller fraction of molecules
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Linking drivers of plant per- and polyfluoroalkyl substance (PFAS) uptake to agricultural land management decisions. Biointerphases (IF 2.1) Pub Date : 2023-07-01 Alex E Scearce,Caleb P Goossen,Rachel E Schattman,Ellen B Mallory,Jean D MaCrae
Widespread contamination of the per- and polyfluoroalkyl substance (PFAS) in agricultural areas is largely attributed to the application of sewage sludge in which the PFAS can be concentrated. This creates a pathway for these contaminants to enter the food chain and, by extension, causes human health and economic concerns. One barrier to managing land with PFAS contamination is the variation in reported
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Immobilization of horseradish peroxidase with zwitterionic polymer material for industrial phenolic removal. Biointerphases (IF 2.1) Pub Date : 2023-07-01 Qi Wang,Hao Fu,Xiaoyu Qi,Lei Zhang,Hongyan Ma
Horseradish peroxidase (HRP) is a hemoglobin composed of a single peptide chain that catalyzes the oxidation of various substrates such as phenol and aniline in the presence of hydrogen peroxide via its iron-porphyrin catalytic center. This enzyme is widely used in industrial phenol removal, food additives, biomedicine, and clinical test reagents due to its rapid reaction rate and obvious reaction
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Silane coupling agent in biomedical materials. Biointerphases (IF 2.1) Pub Date : 2023-05-01 Ze-Qun Zhang,Ke-Feng Ren,Jian Ji
Medical devices are becoming more and more significant in our daily life. For implantable medical devices, good biocompatibility is required for further use in vivo. Thus, surface modification of medical devices is really important, which gives a wide application scene for a silane coupling agent. The silane coupling agent is able to form a durable bond between organic and inorganic materials. The
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Quantitative evaluation of perfluorinated alkanethiol molecular order on gold surfaces. Biointerphases (IF 2.1) Pub Date : 2023-05-01 Lara J Gamble,David Radford,David W Grainger,David G Castner
Self-assembled monolayers (SAMs) of perfluoroalkanethiols [CF3(CF2)xCH2CH2SH (x = 3, 5, 7, and 9)] on gold were characterized by x-ray photoelectron spectroscopy (XPS), near edge x-ray absorption fine structure (NEXAFS), and static time-of-flight secondary ion mass spectrometry (ToF-SIMS). Perfluoroalkanethiols of several chain lengths were synthesized using a known hydride reduction method for transforming
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Antimicrobial efficacy of cyclic α- and β-peptides incorporated in polyurethane coatings. Biointerphases (IF 2.1) Pub Date : 2023-05-01 Qin Lu,Daniel P Regan,Daniel E Barlow,Kenan P Fears
Microbial growth on surfaces poses health concerns and can accelerate the biodegradation of engineered materials and coatings. Cyclic peptides are promising agents to combat biofouling because they are more resistant to enzymatic degradation than their linear counterparts. They can also be designed to interact with extracellular targets and intracellular targets and/or self-assemble into transmembrane
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High throughput wide field second harmonic imaging of giant unilamellar vesicles. Biointerphases (IF 2.1) Pub Date : 2023-05-01 M Eremchev,D Roesel,P-M Dansette,A Michailovas,S Roke
Cell-sized giant unilamellar vesicles (GUVs) are an ideal tool for understanding lipid membrane structure and properties. Label-free spatiotemporal images of their membrane potential and structure would greatly aid the quantitative understanding of membrane properties. In principle, second harmonic imaging is a great tool to do so, but the low degree of spatial anisotropy that arises from a single
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Evidence of compost contamination with per- and polyfluoroalkyl substances (PFAS) from "compostable" food serviceware. Biointerphases (IF 2.1) Pub Date : 2023-05-01 Caleb P Goossen,Rachel E Schattman,Jean D MacRae
Per- and polyfluoroalkyl substances (PFAS) have been used to waterproof and greaseproof food serviceware for decades. Health concerns about these compounds have drawn attention to the potential for contamination of the food system. Finished compost (n = 3) made from manure and food serviceware labeled "compostable" generated at a large fair was found to contain 12 or 13 of the 28 PFAS compounds sampled
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Comparison study of mouse brain tissue by using ToF-SIMS within static limits and hybrid SIMS beyond static limits (dynamic mode). Biointerphases (IF 2.1) Pub Date : 2023-05-01 Hyun Kyong Shon,Jin Gyeong Son,Sun Young Lee,Jeong Hee Moon,Ga Seul Lee,Kyoung-Shim Kim,Tae Geol Lee
In the study of degenerative brain diseases, changes in lipids, the main component of neurons, are particularly important because they are used as indicators of pathological changes. One method for the sensitive measurement of biomolecules, especially lipids, is time-of-flight secondary ion mass spectrometry (ToF-SIMS) using pulsed argon cluster ions. In this study, biomolecules including various lipids
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Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS. Biointerphases (IF 2.1) Pub Date : 2023-05-01 Heba Khateb,Andrew L Hook,Stefanie Kern,Julie A Watts,Sonali Singh,Darryl Jackson,Luisa Marinez-Pomares,Paul Williams,Morgan R Alexander
Secondary ion mass spectrometry (SIMS) offers advantages over both liquid extraction mass spectrometry and matrix assisted laser desorption mass spectrometry in that it provides the direct in situ analysis of molecules and has the potential to preserve the 3D location of an analyte in a sample. Polysaccharides are recognized as challenging analytes in the mass spectrometry of liquids and are also difficult
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Time-of-flight SIMS investigation of peptides containing cell penetrating sequences. Biointerphases (IF 2.1) Pub Date : 2023-05-01 Alessandro Auditore,Nunzio Tuccitto,Giuseppe Grasso,Olivier Monasson,Elisa Peroni,Antonino Licciardello
Surface functionalization with biological molecules, such as peptides or proteins, is a very promising method for developing new biomaterials with many potential applications. However, due to their chemical complexity, the characterization of biological materials is often a very challenging task. In this context, time-of-flight secondary ion mass spectrometry is a very helpful characterization tool
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Molecular simulation studies on a zwitterionic peptide-dendrimer conjugate for integrin αvβ3 binding. Biointerphases (IF 2.1) Pub Date : 2023-05-01 Xiaowei Lin,Nan Xu,Chen Li,Zhiyu Wu,Shengfu Chen,Yao Shi,Yi He
Zwitterionic dendrimer is an effective carrier, which can restore the natural conformation of peptide segments for high bioaffinity by a hydrogen bond-induced conformational constraint approach. However, it is still unknown whether the approach is applicable for the dendrimers with different geometric sizes. Therefore, the characteristics of conjugates made from zwitterionic poly(amidoamine) (PAM)
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Facilitated osteogenesis of magnesium implant by coating of strontium incorporated calcium phosphate. Biointerphases (IF 2.1) Pub Date : 2023-05-01 Jung-Eun Park,Yong-Seok Jang,Jae-Min Seo,Min-Ho Lee
This study investigated the corrosion resistance and biocompatibility of magnesium coated with strontium-doped calcium phosphate (Sr-CaP) for dental and orthopedic applications. Sr-CaP was coated on biodegradable magnesium using a chemical dipping method. Magnesium coated with Sr-CaP exhibited better corrosion resistance than pure magnesium. Sr-CaP-coated magnesium showed excellent cell proliferation
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Interdependence of cholesterol distribution and conformational order in lipid bilayers. Biointerphases (IF 2.1) Pub Date : 2023-05-01 Mohammadreza Aghaaminiha,Amir M Farnoud,Sumit Sharma
We show, via molecular simulations, that not only does cholesterol induce a lipid order, but the lipid order also enhances cholesterol localization within the lipid leaflets. Therefore, there is a strong interdependence between these two phenomena. In the ordered phase, cholesterol molecules are predominantly present in the bilayer leaflets and orient themselves parallel to the bilayer normal. In the
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Back to the basics of time-of-flight secondary ion mass spectrometry data analysis of bio-related samples. II. Data processing and display. Biointerphases (IF 2.1) Pub Date : 2023-05-01 Daniel J Graham,Lara J Gamble
This is the second half of a two-part Tutorial on the basics of the time-of-flight secondary ion mass spectrometry (ToF-SIMS) analysis of bio-related samples. Part I of this Tutorial series covers planning for a ToF-SIMS experiment, preparing and shipping samples, and collecting ToF-SIMS data. This Tutorial aims at helping the ToF-SIMS user to process, display, and interpret ToF-SIMS data. ToF-SIMS
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Insight into the assembly of lipid-hyaluronan complexes in osteoarthritic conditions. Biointerphases (IF 2.1) Pub Date : 2023-04-11 Kangdi Sun,Tooba Shoaib,Mark W Rutland,Joseph Beller,Changwoo Do,Rosa M Espinosa-Marzal
Interactions between molecules in the synovial fluid and the cartilage surface may play a vital role in the formation of adsorbed films that contribute to the low friction of cartilage boundary lubrication. Osteoarthritis (OA) is the most common degenerative joint disease. Previous studies have shown that in OA-diseased joints, hyaluronan (HA) not only breaks down resulting in a much lower molecular
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Evaluation of focal adhesion mediated subcellular curvature sensing in response to engineered extracellular matrix. Biointerphases (IF 2.1) Pub Date : 2023-04-05 Daniel T Bowers,Mary Elizabeth McCulloch,Justin L Brown
Fibril curvature is bioinstructive to attached cells. Similar to natural healthy tissues, an engineered extracellular matrix can be designed to stimulate cells to adopt desired phenotypes. To take full advantage of the curvature control in biomaterial fabrication methodologies, an understanding of the response to fibril subcellular curvature is required. In this work, we examined morphology, signaling
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Back to the basics of time-of-flight secondary ion mass spectrometry of bio-related samples. I. Instrumentation and data collection. Biointerphases (IF 2.1) Pub Date : 2023-03-29 Daniel J Graham,Lara J Gamble
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is used widely throughout industrial and academic research due to the high information content of the chemically specific data it produces. Modern ToF-SIMS instruments can generate high mass resolution data that can be displayed as spectra and images (2D and 3D). This enables determining the distribution of molecules across and into a surface
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3D bioprinting of gastrointestinal cancer models: A comprehensive review on processing, properties, and therapeutic implications. Biointerphases (IF 2.1) Pub Date : 2023-03-24 Kalappa Prashantha,Amita Krishnappa,Malini Muthappa
Gastrointestinal tract (GIT) malignancies are an important public health problem considering the increased incidence in recent years and the high morbidity and mortality associated with it. GIT malignancies constitute 26% of the global cancer incidence burden and 35% of all cancer-related deaths. Gastrointestinal cancers are complex and heterogenous diseases caused by the interplay of genetic and environmental
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Biocompatibility evaluation of polyethersulfone-pyrolytic carbon composite membrane in artificial pancreas. Biointerphases (IF 2.1) Pub Date : 2023-03-21 Reza Peighami,Mohamadreza Mehrnia,Fatemeh Yazdian,Mojgan Sheikhpour
Polyethersulfone (PES) membranes are widely used in medical devices, especially intravascular devices such as intravascular bioartificial pancreases. In the current work, the pure PES and PES-pyrolytic carbon (PyC) composite membranes were synthesized and permeability studies were conducted. In addition, the cytocompatibility and hemocompatibility of the pure PES and PES-PyC membranes were investigated
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Bioconjugation of COL1 protein on liquid-like solid surfaces to study tumor invasion dynamics. Biointerphases (IF 2.1) Pub Date : 2023-03-10 D T Nguyen,D I Pedro,A Pepe,J G Rosa,J I Bowman,L Trachsel,G R Golde,I Suzuki,J M Lavrador,N T Y Nguyen,M A Kis,R A Smolchek,N Diodati,R Liu,S R Phillpot,A R Webber,P Castillo,E J Sayour,B S Sumerlin,W G Sawyer
Tumor invasion is likely driven by the product of intrinsic and extrinsic stresses, reduced intercellular adhesion, and reciprocal interactions between the cancer cells and the extracellular matrix (ECM). The ECM is a dynamic material system that is continuously evolving with the tumor microenvironment. Although it is widely reported that cancer cells degrade the ECM to create paths for migration using
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Liposome functionalized reduced graphene oxide for rapid electrochemical sensing of bacteria. Biointerphases (IF 2.1) Pub Date : 2023-03-01 Shailendra Kumar,Juhi Jaiswal,Snehlata Yadav,Marshal Dhayal
Pathogenic bacteria represent a severe threat to global public health, particularly with the growing rate of antibiotic resistance, and, therefore, indicate a critical need for developing efficient sensing platforms. Liposome-based sensors are collocating interest due to their intrinsic fusogenic ability to fuse with the outer membrane of bacteria. However, the lack of a conducting property limits
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Polyacrylonitrile nanofibrous membrane composited with zeolite imidazole skeleton-8 and silver nanoclusters for efficient antibacterial and emulsion separation. Biointerphases (IF 2.1) Pub Date : 2023-03-01 Huaxiang Chen,Hao Zhou,Mingchao Chen,Yan Quan,Chenglong Wang,Yujie Gao,Jindan Wu
Oily wastewater discharged by industrial development is an important factor causing water pollution. Membrane separation technology has the advantages of low cost, simple operation, and high efficiency in the treatment of oily wastewater. However, membrane materials are easily eroded by microorganisms during long-term storage or use, thereby resulting in reduced separation efficiency. Herein, a zeolite
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Production of WE43 magnesium alloy by powder metallurgy and the effect of glucose on wear resistance in biocorrosive wear. Biointerphases (IF 2.1) Pub Date : 2023-03-01 Bünyamin Çiçek
In this study, WE43 magnesium alloy was produced by the powder metallurgy method. Microstructural analyses of the produced samples were carried out using the scanning electron microscopy method. X-ray fluorescence, energy dispersive x-ray (EDS) analysis, and hardness tests were also implemented to investigate the physical and chemical properties of the alloys. The volumetric hardness was measured to
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Atomistic simulations for investigation of substrate effects on lipid in-source fragmentation in secondary ion mass spectrometry Biointerphases (IF 2.1) Pub Date : 2023-02-09 Michael J. Taylor, Hoshin Kim, William Kew, Amity Andersen, Arunima Bhattacharjee, Mark H. Engelhard, Christopher R. Anderton
In beam-based ionization methods, the substrate plays an important role on the desorption mechanism of molecules from surfaces. Both the specific orientation that a molecule adopts at a surface and the strength of the molecule-surface interaction can greatly influence desorption processes, which in turn will affect the ion yield and the degree of in-source fragmentation of a molecule. In the beam-based
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Probing the human epidermis by combining ToF-SIMS and multivariate analysis Biointerphases (IF 2.1) Pub Date : 2023-02-08 Xavier Delvaux, Céline Noël, Yves Poumay, Laurent Houssiau
The mammalian organism is continuously exposed to various biological and chemical threats from its surroundings. In order to provide protection against these threats, mammals have developed a specialized defense system at the interface with their environment. This system, known as the epidermis, is mainly composed of stratified keratinocytes organized in a complex self-renewing structure providing
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Polymer brushes for friction control: Contributions of molecular simulations Biointerphases (IF 2.1) Pub Date : 2023-01-18 Mohamed A. Abdelbar, James P. Ewen, Daniele Dini, Stefano Angioletti-Uberti
When polymer chains are grafted to solid surfaces at sufficiently high density, they form brushes that can modify the surface properties. In particular, polymer brushes are increasingly being used to reduce friction in water-lubricated systems close to the very low levels found in natural systems, such as synovial joints. New types of polymer brush are continually being developed to improve with lower
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UV- and thermally-active small bi-functional gelator for creating gradient polymer network coatings Biointerphases (IF 2.1) Pub Date : 2023-01-10 Pandiyarajan Chinnayan Kannan, Jan Genzer
We present a versatile one-pot synthesis method for creating surface-anchored orthogonal gradient networks using a small bi-functional gelator, 4-azidosulfonylphenethyltrimethoxysilane (4-ASPTMS). The sulfonyl azide (SAz) group of 4-ASPTMS is UV (≤254 nm) and thermally active (≥100 °C) and, thus, enables us to vary the cross-link density in orthogonal directions by controlling the activation of SAz
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Phase separation in polymer-based biomimetic structures containing planar membranes Biointerphases (IF 2.1) Pub Date : 2022-12-27 Maryame Bina, Flavien Sciortino, Agata N. Mahrir
Phase separation in biological membranes is crucial for proper cellular functions, such as signaling and trafficking, as it mediates the interactions of condensates on membrane-bound organelles and transmembrane transport to targeted destination compartments. The separation of a lipid bilayer into phases and the formation of lipid rafts involve the restructuring of molecular localization, their immobilization
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Differentiating interactions of antimicrobials with Gram-negative and Gram-positive bacterial cell walls using molecular dynamics simulations Biointerphases (IF 2.1) Pub Date : 2022-12-07 Rakesh Vaiwala, Pradyumn Sharma, K. Ganapathy Ayappa
Developing molecular models to capture the complex physicochemical architecture of the bacterial cell wall and to study the interaction with antibacterial molecules is an important aspect of assessing and developing novel antimicrobial molecules. We carried out molecular dynamics simulations using an atomistic model of peptidoglycan to represent the architecture for Gram-positive S. aureus. The model
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Modification of nitrile hydratase fromRhodococcus erythropolisCCM2595 by semirational design to enhance its substrate affinity Biointerphases (IF 2.1) Pub Date : 2022-12-01 Li Wang, Baocheng Cui, Keyuan Qiu, Jiao Huang, Changhai Liang
Nitrile hydratase (NHase, EC 4.2.1.84) is an excellent biocatalyst that catalyzes the hydration of nitrile substances to their corresponding amides. Given its catalytic specificity and eco-friendliness, NHase has extensive applications in the chemical, pharmaceutical, and cosmetic industries. To improve the affinity between Rhodococcus erythropolis CCM2595-derived NHase (ReNHase) and adiponitrile,
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Smart DNA nanogel coated polydopamine nanoparticle with high drug loading for chemo-photothermal therapy of cancer Biointerphases (IF 2.1) Pub Date : 2022-11-16 Shiyu Zang, Xunxun Deng, Jiamian Wang, Yanqiu Zhao, Shuo Wu
A smart deoxyribose nucleic acid nanogel coated polydopamine nanosphere hybrid was designed for chemo-photothermal therapy of cancer. The nanohybrid showed good colloid stability, narrow size distribution, high drug loading, good biocompatibility, and high photothermal conversion efficiency, and could release the drug on desired tumor sites.
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Anchoring silver nanoparticles on nanofibers by thermal bonding to construct functional surface Biointerphases (IF 2.1) Pub Date : 2022-11-14 Bingjie Xu, Langfei Yang, Wei Pan, Ying Li, Zili Wang, Guoqiang Cai, Jindan Wu, Dongming Qi
Generally, the anchoring of inorganic nanoparticles onto the surface of fibers faces the problem of poor stability, which limits the wide application of nanoparticle functionalized fibers. Herein, nanofibers with shell-core structures were constructed by coaxial electrospinning of two polymers with different melting points (Tm). Polyglycolic acid (PGA, Tm = 225 °C) was employed as the core layer, while
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Fine-tuned magnetic nanobubbles for magnetic hyperthermia treatment of glioma cells Biointerphases (IF 2.1) Pub Date : 2022-11-11 Bin Li, Yuexia Han, Yang Liu, Fang Yang
Magnetic nanoparticle (MNP) induced magnetic hyperthermia has been demonstrated as a promising technique for the treatment of brain tumor. However, lower heating efficiency resulting from low intratumoral accumulation of magnetic nanomaterials is still one of the significant limitations for their thermotherapeutic efficacy. In this study, we have designed a nanobubble structure with MNPs decorated
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Shape-dependent gold nanoparticle interactions with a model cell membrane Biointerphases (IF 2.1) Pub Date : 2022-11-08 Thaddeus W. Golbek, Bryan J. Harper, Stacey L. Harper, Joe E. Baio
Customizable gold nanoparticle platforms are motivating innovations in drug discovery with massive therapeutic potential due to their biocompatibility, stability, and imaging capabilities. Further development requires the understanding of how discrete differences in shape, charge, or surface chemistry affect the drug delivery process of the nanoparticle. The nanoparticle shape can have a significant
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Composition controls soft hydrogel surface layer dimensions and contact mechanics Biointerphases (IF 2.1) Pub Date : 2022-11-07 Christopher L. Johnson, Alison C. Dunn
Hydrogels are soft hydrated polymer networks that are widely used in research and industry due to their favorable properties and similarity to biological tissues. However, it has long been difficult to create a hydrogel emulating the heterogeneous structure of special tissues, such as cartilage. One potential avenue to develop a structural variation in a hydrogel is the “mold effect,” which has only
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Emerging biomaterials and technologies to control stem cell fate and patterning in engineered 3D tissues and organoids Biointerphases (IF 2.1) Pub Date : 2022-11-07 Mojtaba Farahani, James Carthew, Sanchyan Bhowmik, Chloe Shard, Ana Nunez-Nescolarde, Guillermo A. Gomez, Victor J. Cadarso, Alexander N. Combes, Jessica E. Frith
The ability to create complex three-dimensional cellular models that can effectively replicate the structure and function of human organs and tissues in vitro has the potential to revolutionize medicine. Such models could facilitate the interrogation of developmental and disease processes underpinning fundamental discovery science, vastly accelerate drug development and screening, or even be used to
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Gold nanoparticle design for RNA compaction Biointerphases (IF 2.1) Pub Date : 2022-11-02 Jessica A. Nash, Matthew D. Manning, Alexey V. Gulyuk, Aleksey E. Kuznetsov, Yaroslava G. Yingling
RNA-based therapeutics hold a great promise in treating a variety of diseases. However, double-stranded RNAs (dsRNAs) are inherently unstable, highly charged, and stiff macromolecules that require a delivery vehicle. Cationic ligand functionalized gold nanoparticles (AuNPs) are able to compact nucleic acids and assist in RNA delivery. Here, we use large-scale all-atom molecular dynamics simulations
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Assessing dead time effects when attempting isotope ratio quantification by time-of-flight secondary ion mass spectrometry. Biointerphases (IF 2.1) Pub Date : 2022-11-01 Laura C Baqué,Federico M Cabello,Federico A Viva,Horacio R Corti
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a quasi-non-destructive technique capable of analyzing the outer monolayers of a solid sample and detecting all elements of the periodic table and their isotopes. Its ability to analyze the outer monolayers resides in sputtering the sample surface with a low-dose primary ion gun, which, in turn, imposes the use of a detector capable of counting
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Construction strategies and the development trend of antibacterial surfaces Biointerphases (IF 2.1) Pub Date : 2022-10-31 Haixia Wu, Wei Liu, Caixia Liu, Can Ai
The construction of antibacterial surfaces is an efficient way to respond to the problem of microbial contamination. In this review, we first describe the formation process and characteristics of microbial contamination and the current research status of antibacterial surfaces. Then, the passive antiadhesion, active killing, and combination construction strategies of the antibacterial surface are discussed
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Mussel adhesion: A fundamental perspective on factors governing strong underwater adhesion Biointerphases (IF 2.1) Pub Date : 2022-10-31 Laura L. E. Mears, Julia Appenroth, Hui Yuan, Alper T. Celebi, Pierluigi Bilotto, Alexander M. Imre, Bruno Zappone, Rongxin Su, Markus Valtiner
Protein-based underwater adhesives of marine organisms exhibit extraordinary binding strength in high salinity based on utilizing a variety of molecular interaction mechanisms. These include acid-base interactions, bidentate bindings or complex hydrogen bonding interactions, and electrochemical manipulation of interfacial bonding. In this Perspective, we briefly review recent progress in the field
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3D cell/scaffold model based on aligned-electrospun-nanofiber film/hydrogel multilayers for construction of anisotropic engineered tissue Biointerphases (IF 2.1) Pub Date : 2022-10-10 Jing-Yi Zhang, Nihad Cheraga, Ning-Ping Huang
Many tissues have a three-dimensional (3D) anisotropic structure compatible with their physiological functions. Engineering an in vitro 3D tissue having the natural structure and functions is a hotspot in tissue engineering with application for tissue regeneration, drug screening, and disease modeling. Despite various designs that have successfully guided the cellular alignment, only a few of them
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Interleukin 1β and lipopolysaccharides induction dictate chondrocyte morphological properties and reduce cellular roughness and adhesion energy comparatively Biointerphases (IF 2.1) Pub Date : 2022-09-30 Alia H. Mallah, Mahmoud Amr, Arda Gozen, Juana Mendenhall, Bernard J. Van-Wie, Nehal I. Abu-Lail
Osteoarthritis (OA) is a whole joint disease marked by the degradation of the articular cartilage (AC) tissue, chronic inflammation, and bone remodeling. Upon AC’s injury, proinflammatory mediators including interleukin 1β (IL1β) and lipopolysaccharides (LPS) play major roles in the onset and progression of OA. The objective of this study was to mechanistically detect and compare the effects of IL1β
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Vibrational sum frequency spectroscopy of thin film interfaces Biointerphases (IF 2.1) Pub Date : 2022-09-23 Erin G. Moloney, Md. S. Azam, Canyu Cai, Dennis K. Hore
We describe a basic theoretical treatment of how film–substrate and substrate–environment (air, water, and solution) interfaces can be selectively probed by controlling the film thickness and beam angles in a visible-infrared sum frequency generation experiment. In this model, we also account for the unique interfacial environment that may have optical properties that differ from the adjacent bulk
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Tutorial on the instrumentation of sum frequency generation vibrational spectroscopy: Using a Ti:sapphire based system as an example Biointerphases (IF 2.1) Pub Date : 2022-09-07 Lujuan Yang, Wenkai Zhang, Hongtao Bian, Gang Ma
Sum frequency generation vibrational spectroscopy (SFG-VS) is an intrinsically surface-selective vibrational spectroscopic technique based on the second-order nonlinear optical process. Since its birth in the 1980s, SFG-VS has been used to solve interfacial structure and dynamics in a variety of research fields including chemistry, physics, materials sciences, biological sciences, environmental sciences
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Tutorials in vibrational sum frequency generation spectroscopy. III. Collecting, processing, and analyzing vibrational sum frequency generation spectra Biointerphases (IF 2.1) Pub Date : 2022-08-05 James D. Pickering, Mikkel Bregnhøj, Mette H. Rasmussen, Kris Strunge, Tobias Weidner
In this Tutorial series, we aim to provide an accessible introduction to vibrational sum frequency generation (VSFG) spectroscopy, targeted toward people entering the VSFG world without a rigorous formal background in optical physics or nonlinear spectroscopy. In this article, we discuss in detail the processes of collecting and processing VSFG data, and user-friendly processing software (sfgtools)
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New antimicrobial peptide-antibiotic combination strategy forPseudomonas aeruginosainactivation Biointerphases (IF 2.1) Pub Date : 2022-08-03 Wenxu Han, Ziqi Wei, Terri A. Camesano
Novel antimicrobials or new treatment strategies are urgently needed to treat Pseudomonas aeruginosa (P. aeruginosa) related infections and especially to address the problem of antibiotic resistance. We propose a novel strategy that combines the human antimicrobial peptide (AMP) LL37 with different antibiotics to find synergistic AMP-antibiotic combinations against P. aeruginosa strains in vitro. Our
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Microstructural, mechanical, andin vitrocorrosion properties of biodegradable Mg-Ag alloys Biointerphases (IF 2.1) Pub Date : 2022-07-06 Levent Elen, Yunus Turen, Hayrettin Ahlatci, Mehmet Unal, Deniz Ergin
In this study, casting, extrusion, biocorrosion, and corrosive wear properties of 0.5 wt. % (Zn, Ca, and Nd) element added Mg—3 wt. % Ag alloys were investigated. According to the test results, it was observed that the grain refinement occurred with the effect of Zn and Ca element additions in the as-cast alloys and thus some mechanical properties of the alloys improved. Similarly, the extrusion process