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Chitosan-based nanoparticles as delivery-carrier for promising antimicrobial glycolipid biosurfactant to improve the eradication rate of Helicobacter pylori biofilm J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2021-01-11 Muhammad Arif; Mohamed Sharaf; Samreen; Sohaib Khan; Zhe Chi; Chen-Guang Liu
Abstract Driven by the need to find alternatives to control H. pylori infections, this work describes the development of chitosan-PMLA nanoparticulate systems as carriers for antimicrobial glycolipid. By using a simple ionic gelation method stable nanoparticle was obtained showing an encapsulation efficiency of 73.1 ± 1.3% and an average size of 217.0 ± 15.6 nm for rhamnolipids chitosan-PMLA nanoparticles
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Efficient synthesis strategy of folate-modified carboxymethyl chitosan (FCMC)/CaCO3 hybrid nanospheres and their drug-carrying and sustained release properties J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2021-01-11 Jianfeng Guo; Juhui Liu; Haoran Qie; Feng Zhao; Catherine Hui Niu
Abstract Folate-modified carboxymethyl chitosan (FCMC) was made by using folate acid as targeted group and attaching folate to carboxymethyl chitosan, and then targeted FCMC/CaCO3 hybrid nanosphere were formed by self-assembly of calcium carbonate in FCMC solution. The physicochemical properties of the nanospheres were investigated by fourier transform infrared spectroscopy (FTIR) X-ray diffraction
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A review on surface modification methods of poly(arylsulfone) membranes for biomedical applications J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-12-30 Vahid Hoseinpour; Laya Noori; Saba Mahmoodpour; Zahra Shariatinia
Abstract Considerable methods have so far been used for the surface modification of biomedical membranes. Several reviews and articles have been published on the improvements achieved in the field of poly(arylsulfone) membranes subjected to various surface modification methods and used in biomedical applications. This review concentrates on the surface modification, biological applications and future
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Formulation development and characterization of Lumefantrine nanosuspension for enhanced antimalarial activity J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-12-30 Ripalkumar Shah; Tejal Soni; Unnati Shah; B. N. Suhagia; M. N. Patel; Tejas Patel; Gamal A. Gabr; Bapi Gorain; Prashant Kesharwani
Abstract Variable and low oral bioavailability (4-11%) of lumefantrine (LUF), an anti-malarial agent, is characterized by very low solubility in aqueous vehicle. Thus, the present study was intended to formulate lyophilized nanosuspensions of LUF to resolve its solubility issues for the improvement of oral bioavailability. A three level 32 factorial design was applied to analyze the influence of independent
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Boosting osteogenic potential and bone regeneration by co cultured cell derived extracellular matrix incorporated porous electrospun scaffold J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-12-29 Andrew Padalhin; Reiza Ventura; Boram Kim; Tamanna Sultana; Chan Mi Park; Byong-Taek Lee
Abstract Implants for bone regeneration to remedy segmental bone defects, osteomyelitis, necrotic bone tissue and non-union fractures have worldwide appeal. Although biomaterials offer most of the advantages by improving tissue growth but developments are more commonly achieved via biologically derived molecules. To aid site specific bone tissue regeneration by synthetic scaffold, cell derived extracellular
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The study of mechanical and drug release properties of the mineralized collagen/polylactic acid scaffold by tuning the crystalline structure of polylactic acid J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-12-24 HuaJie Ren; Xiaojie Lian; Baolong Niu; Liqin Zhao; Quanyou Zhang; Di Huang; Yan Wei; Zhijun Li; Zhimin He; Zhiye Qiu
Abstract Open bone fractures in clinical are not only difficult to heal but also at a high risk of infections. Annual cases of fractures which result from osteoporosis amount to approximately 9 million. The objective of this study is to load the antibiotic drug of vancomycin and tune its controlled delivery on a bone repair scaffold material of Mineralized Collagen/poly(lactic acid) (MCP) via changing
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Co-delivery of cisplatin and doxorubicin by carboxylic acid functionalized poly (hydroxyethyl methacrylate)/reduced graphene nanocomposite for combination chemotherapy of breast cancer cells J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-12-21 Shahram Astani; Roya Salehi; Bakhshali Massoumi; Abdolhossein Massoudi
Abstract In this study a novel pH-responsive magnetic nanocomposite based on reduced graphene oxide was developed for combination of doxorubicin (Dox)-cisplatin (Cis) delivery to destroy the MCF-7 cell line. For this purpose, polyhydroxyethyl methacrylate (PHEMA) was bonded to the reduced graphene oxide through ATRP polymerization using grafting from method. Then the PHEMA hydroxy groups were converted
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A core-shell structured alginate hydrogel beads with tunable thickness of Carboxymethyl cellulose coating for pH responsive drug delivery J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-12-21 Mingzhu Yan; Tiantian Chen; Shuping Zhang; Ting Lu; Ximeng Sun
Abstract pH-responsive core-shell structured composite hydrogel beads, composed of a alginate (ALG) core coated with carboxymethyl cellulose (CMC) shell (ALG@CMC), were prepared by using in-situ gel preparation technology as a drug delivery system. An anti-inflammatory drug, indomethacin was loaded into the formed hydrogels as a model drug. The resulting gel samples were characterized by Fourier transforms
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Antiproliferative Drug-loaded Multi-functionalized Intraocular Lens for Reducing Posterior Capsular Opacification J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-12-17 Huiying Huang; Siqing Zhu; Dong Liu; Shimin Wen; Quankui Lin
ABSTRACT Posterior capsule opacification (PCO) is one of the most frequent complications in cataract surgery and likely to cause the second loss of vision. Proliferation and migration of postoperative remnants of lens epithelial cells (LECs) on the implanted intraocular lens (IOL) are the leading causes of PCO. Antiproliferative drugs can be an effective solution but also possess some problems including
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Designed and Fabrication of triple-layered vascular scaffold with microchannels J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-12-17 Qingxi Hu; Zhipeng Shen; Haiguang Zhang; Suihong Liu; Rui Feng; Jiaxuan Feng; Murugan Ramalingam
ABSTRACT Currently, one of the best preparation strategies for the triple-layered vascular scaffold is to imitate the three-layer structure of natural blood vessels to achieve the biofunctional characteristics of vascular transplantation. Here, we developed a combinatorial method to fabricate triple-layered vascular scaffold (TVS) by using electrospinning and coaxial 3D printing. First, Polycaprolactone-collagen
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The thermal/pH-sensitive drug delivery system encapsulated by PAA based on hollow hybrid nanospheres with two silicon source J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-12-10 Keju Zhang; Yuhong Zhang; Yulin Li; Zoya Iqbal; Li Yu; Jiyan Liu; Haiping Wang; Peixin He
Abstract The synthesis of drug delivery systems based on hollow mesoporous silica nanoparticles (MSNs) is still a major challenge. In this work, the hollow hybrid MSNs were successfully prepared by cetyltrimethylammonium bromide-directed sol − gel process and one-step hydrothermal treatment process. The hollow hybrid MSNs had hybrid ethane bridged frameworks with the uniform particle size (250 nm)
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Multi-layer PDMS films having antifouling property for biomedical applications J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-28 M. Mousavi; H. Ghaleh; K. Jalili; F. Abbasi
Abstract Poly(dimethylsiloxane) (PDMS) elastomer is now a well-known material for packaging implantable biomedical micro-devices owing to unique bulk properties such as biocompatibility, low toxicity, excellent rheological properties, good flexibility, and mechanical stability. Despite the desirable bulk characteristics, PDMS is generally regarded as a high-flux material for oxygen and water vapor
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Multi-stimuli-responsive, liposome-crosslinked poly(ethylene glycol) hydrogels for drug delivery J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-24 Luisa L. Palmese; Ming Fan; Rebecca A. Scott; Huaping Tan; Kristi L. Kiick
The development of hybrid hydrogels has been of great interest over recent decades, especially in the field of biomaterials. Such hydrogels provide various opportunities in tissue engineering, drug delivery, and regenerative medicine due to their ability to mimic cellular environments, sequester and release therapeutic agents, and respond to stimuli. Herein we report the synthesis and characterization
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Enhancing the solubility of nitazoxanide with solid dispersions technique: formulation, evaluation, and cytotoxicity study J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-23 Shikha Sood; Balaji Maddiboyina; Pinki Rawat; Ashish Kumar Garg; Ahmed I. Foudah; Aftab Alam; Hibah M. Aldawsari; Yassine Riadi; Sima Singh; Prashant Kesharwani
Abstract Nitazoxanide (NTZ) is a synthetic form of nitrothiazole with a broad range of applications as an antiparasitic, antibacterial and antiviral agent. NTZ is a highly low aqueous soluble drug which possesses solubility of 0.00755 mg/mL and typically low bioavailability of 1%. Low aqueous solubility is usually regarded as prime prerequisites for enhanced absorption and bioavailability. The purpose
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Synthesis and characterization of PLGA-PEG-PLGA based thermosensitive polyurethane micelles for potential drug delivery J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-20 Min Wang; Jianghao Zhan; Laijun Xu; Yanjun Wang; Dan Lu; Zhen Li; Jiehua Li; Feng Luo; Hong Tan
ABSTRACT Polyurethane nanomicelle is a promising functional drug delivery system. In this work, the polyurethane (P3-PU) was synthesized from PLGA1200-PEG1450-PLGA1200 (P3, a thermosensitive and biodegradable triblock copolymer) and L-lysine ester diisocyanate (LDI). Then, reactive benzaldehyde was further imported to terminate P3-PU to obtain benzaldehyde modified polyurethane (P3-PUDA). The micelles
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Effect of membrane parameters and filter structure on the efficiency of leukocyte removal by electrospun poly(ethylene-co-vinyl alcohol) membranes J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-17 P. V. Mayuri; Anugya Bhatt; A. Sabareeswaran; P. Ramesh
Abstract Electrospinning technology is an experimentally verified tool for the generation of membranes with competing efficiency useful for leukodepletion filter, customarily used in blood banks to lessen the risks with blood transfusions. Even though a few electrospun polymers have been reported to be efficient leukodepletion filter membranes, poly(ethylene-co-vinyl alcohol) (EVAL) being one among
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Preparation, Characterization and Application of Curcumin based Polymeric Bio-composite for Efficient Removal of Endotoxins and Bacterial Cells from Therapeutic Preparations J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-13 Pragya Prakash; Hare Ram Singh; Santosh Kumar Jha
Abstract Polymer science offers a great insight and a new research dimension for biomedical applications. The synthesis of polymeric materials by the physical ways provides several advantages over the conventional chemical methods. It is though expansive but less toxic, stable, and efficiently reproducible. In the present report, electrospinning was used for bio-composite preparation. The bio-composite
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PEG-Containing Siloxane Materials by Metal-Free Click-Chemistry for Ocular Drug Delivery Applications J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-13 Frances Lasowski; Talena Rambarran; Vida Rahmani; Michael A. Brook; Heather Sheardown
Abstract Metal-free click-chemistry can be used to create silicone hydrogels for ocular drug delivery applications, imparting the benefits of silicones without catalyst contamination. Previous work has demonstrated the capacity for these materials to significantly reduce protein adsorption. Building upon this success, the current work examines and optimizes different materials in terms of their protein
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HEMA and Alginate-based chondrogenic semi-interpenetrated hydrogels: Synthesis and Biological Characterization J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-12 María Luz Torres; Tamara G. Oberti; Juan Manuel Fernández
Abstract Cartilage tissue engineering (CTE) has the general objective of restoring and improving damaged cartilage. A very interesting strategy of CTE is to combine different polymers to obtain a viscoelastic material. In the present study we have evaluated the applicability of Poly(2-hydroxyethyl methacrylate) networks semi-interpenetrated with sodium alginate for CTE. Alginate-containing hydrogels
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Application of Electrospun Nanofibers in Bone, Cartilage and Osteochondral Tissue Engineering J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-11 Huixiu Ding; Yizhu Cheng; Xiaolian Niu; Yinchun Hu
Abstract Tissue damage related to bone and cartilage is a common clinical disease. Cartilage tissue has no blood vessels and nerves. The limited cell migration ability results in low endogenous healing ability. Due to the complexity of the osteochondral interface, the clinical treatment of osteochondral injury is limited. Tissue engineering provides new ideas for solving this problem. The ideal tissue
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Sustained release of tulobuterol from graphene oxide laden hydrogel to manage asthma J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-11 Shujuan Luo; Shijie Jin; Ting Yang; Bichen Wu; Chang Xu; Liyan Luo; Yanping Chen
Abstract Bronchial asthma is a chronic disease which is currently treated using various inhalants. However, the medication adherence with the inhalants is poor due to complex procedure to use them along with frequent dosing. In this paper, we have developed tulobuterol loaded Pluronic® F127-reduced graphene oxide transdermal hydrogel to sustain the release of tulobuterol to manage asthma for days.
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Interconnected porous nanofibrous gelatin scaffolds prepared via a combined thermally induced phase separation/particulate leaching method J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-11-02 E. Sabzi; F. Abbasi; H. Ghaleh
Abstract To mimic the fibrous architecture of collagen, the nanofibrous gelatin scaffolds are fabricated employing a thermally induced phase separation (TIPS) technique. The influences of processing parameters, including polymer concentration and solvent mixture composition on the scaffold microstructure are investigated. However, using the TIPS technique, a limited pore size range is generally obtained
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In Vitro Characterization of Hierarchical 3D Scaffolds Produced by Combining Additive Manufacturing and Thermally Induced Phase Separation J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-10-22 Azizeh-Mitra Yousefi; Joseph Powers; Kaylie Sampson; Katherine Wood; Carter Gadola; Jing Zhang; Paul F. James
Abstract This paper reports on the hybrid process we have used for producing hierarchical scaffolds made of poly(lactic-co-glycolic) acid (PLGA) and nanohydroxyapatite (nHA), analyzes their internal structures via scanning electron microscopy, and presents the results of our in vitro proliferation of MC3T3-E1 cells and alkaline phosphatase activity (ALP) for 0 and 21 days. These scaffolds were produced
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Synthesis, Characterization of Acrylate polymer having chalcone moiety: Evaluation of antimicrobial, anticancer and drug release study J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-10-22 C. Sudhakar; J. Suresh; N. Valarmathi; S. Sumathi; A. Karthikeyan; A. Arun
Abstract This article describes synthesis, characterization, antimicrobial, drug-releasing and anti-cancer activity of acrylate monomer and its polymer containing chalcone moiety. The synthesized polymers were characterized through IR, 1H NMR, and UV-visible spectroscopy techniques. The molecular weight of the obtained polymer is found to be around 4000 g/mol. The synthesized polymers are thermally
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Effects of molecular architecture of photoreactive phospholipid polymer on adsorption and reaction on substrate surface under aqueous condition J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-10-19 Kazuhiko Ishihara; Kohei Suzuki; Yuuki Inoue; Kyoko Fukazawa
Abstract Water-soluble photoreactive polymers with both phosphorylcholine and benzophenone groups were synthesized for the reaction between the polymers and the substrate in aqueous medium. To control the polymer architecture, the living radical polymerization method was applied to the copolymerization of 2-methacryloyloxyethyl phosphorylcholine and benzophenone methacrylates. These polymers possess
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Noncorrelative Relation between In Vitro and In Vivo for Plasmid DNA Transfection by Succinylated Polyethylenimine Muscular Injection J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-10-19 Yuki Kobayashi; Kei Nirasawa; Yoichi Negishi; Shoichiro Asayama
Abstract The polyion complexes (PICs) between plasmid DNA (pDNA) and succinylated branched polyethylenimine (bPEI-Et-COOH) were formed for in vivo pDNA delivery by muscular injection. Transmission electron microscopy (TEM) observation revealed that the PIC between pDNA and bPEI-Et-COOH with higher succinylated degree formed the particle structure with corona-like shell. Furthermore, confocal laser
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3D PCL/fish collagen composite scaffolds incorporating osteogenic abalone protein hydrolysates for bone regeneration application: in vitro and in vivo studies J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-10-16 Van-Tinh Nguyen; Gun-Woo Oh; Seong-Yeong Heo; Seok-Chun Ko; Chang Su Kim; Won Sun Park; Il-Whan Choi; Won-Kyo Jung
Abstract Three-dimensional (3D) printing is an effective technology that has shown considerable potential for use in tissue regeneration. Of the many materials that have been proposed for this purpose, poly (ε-caprolactone) (PCL) 3D scaffolds have been received significant attention in the bone tissue engineering field due to its advantageous mechanical properties and biocompatibility. In this study
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Hyaluronic acid and graphene oxide loaded silicon contact lens for corneal epithelial healing J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-10-15 Chao Huang; Xin Zhang; Yanchun Li; Xiaolan Yang
Abstract Hyaluronic acid (HA) eye drop solution is widely used to treat and manage various corneal diseases like keratoconus (after corneal cross-linking) and dry eye syndrome. However, ocular dosage forms like eye drop solution affect the routine life style of patients due to frequent dosing schedule. In this study, HA and reduced graphene oxide (rGO) was directly loaded in the silicon contact lenses
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Tumor microenvironment responsive nanogels as a smart triggered release platform for enhanced intracellular delivery of doxorubicin J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-10-14 Parveen Kumar; Gautam Behl; Sumeet Kaur; Nalini Yadav; Bo Liu; Aruna Chhikara
Abstract The fabrication of novel and intelligent delivery systems that can effectively deliver therapeutics to the targeted site and release payload in enhanced/controlled manner is highly desired to overcome the multiple challenges in chemotherapy. The present article demonstrates the potential application of dual stimuli responsive nanogels as tumor microenvironment targeted drug delivery carrier
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Synthesis and characterization of a PAMAM dendrimer nanocarrier functionalized by HA for targeted gene delivery systems and evaluation in vitro J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-10-09 Haimei Hu; Han Wang; Shuanghong Liang; Xiaoling Li; Dan Wang
Abstract Poly(amido-amine) (PAMAM), one of the most widely studied dendrimers in the field of drug and gene delivery, can enhance the stability of DNA and deliver it to cell cytosol; hyaluronic acid (HA), a simple disaccharide unit, can polymerize and is considered a polymer of non-immunogenicity, which has an intrinsic targeting property for many cancer cells by interacting with CD 44. In this study
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Synthesis and Characterization of Biphasic Calcium Phosphate Laden Thiolated Hyaluronic Acid Hydrogel Based Scaffold: Physical and in-vitro Biocompatibility Evaluations J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-10-07 Suk Young Hong; Tuong Van Thi Tran; Hoe Jin Kang; Garima Tripathi; Byong Taek Lee; Sang Ho Bae
Abstract The present study focused on the combination of biphasic calcium phosphate (BCP) nanoparticles into the modified hyaluronic acid based injectable hydrogels for bone tissue engineering. Self-cross-linked thiolated hyaluronic acid (HA-HS) injectable hydrogels loaded with biphasic calcium phosphate (BCP) nanoparticles were prepared by disulfide cross-linking to mimic the extracellular matrix
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pH-sensitive curcumin conjugated micelles for tumor triggered drug delivery J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-10-07 Hamid Rashidzadeh; Seyed Jamal Tabatabaei Rezaei; Sahar Zamani; Elnaz Sarijloo; Ali Ramazani
Abstract Development of new drugs are confronted with some barriers and challenges, since these projects are mainly expensive, complex, time consuming with lack of success, there is an urgent need to reformulate the current poorly water soluble anti-cancer drugs. In this study, a new type of polymer–curcumin conjugates based on glycidyl azide polymer (GAP) was developed for cancer therapy. The copolymer
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A Difunctional Pluronic®127 Based Insitu Formed Injectable Thermogels as Prolonged and Controlled Curcumin Depot, Fabrication, Invitro Characterization and Invivo Safety Evaluation J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-25 Samiullah Khan; Naveed Akhtar; Muhammad Usman Minhas; Hassan Shah; Kifayat ullah Khan; Raghu Raj Singh Thakur
Curcumin has been reported to be used widely against many types of pathological conditions in clinics. However due to its limitations such as poor solubility, poor oral absorption and low stability has limited its applications. In current study, a series of novel chemically cross-linkable depot gel formulations were developed based on thermoresponsive micellar polymer (Pluronic®127) with polyelectrolyte
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Experimental study on bone defect repair by BMSCs combined with a light-sensitive material: g-C3N4/rGO J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-25 Jie Liang; Wenhua Li; Ning Zhuang; Sini Wen; Shijia Huang; Weizhi Lu; Yezhen Zhou; Gaozu Liao; Bao Zhang; Chenglong Liu
Bone marrow mesenchymal stem cells (BMSCs), as seed cells, have played an important role in bone defect repair. However, efficiently amplifying and inducing BMSCs in vitro or vivo remains an urgent problem to be solved. Electrical stimulation has been beneficial to the proliferation and differentiation of BMSCs, but current electrical stimulation methods have a critical disadvantage in that they usually
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Osteoconductive and Osteoinductive Biodegradable Microspheres Serving as Injectable Micro-scaffolds for Bone Regeneration. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-23 Jianping Mao,Pengfei Wei,Zuoying Yuan,Wei Jing,Jingjing Cao,Guangping Li,Jianxun Guo,Honggang Wang,Dafu Chen,Qing Cai
There are intensive needs for scaffolds with new designs to meet the diverse requirements of bone repairing. Biodegradable microspheres are highlighted as injectable micro-scaffolds thanks to their advantages in filling irregular defects via a minimally invasive surgery. In this study, microspheres with surface micropores were made via the W1/O/W2 double emulsion method using amphiphilic triblock copolymers
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Preparation of lysozyme loaded gelatin microcryogels and investigation of their antibacterial properties. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-23 Kemal Çetin,Sevgi Aslıyüce,Neslihan Idil,Adil Denizli
Antibacterial micron-sized cryogels, so-called microcryogels, were prepared by cryogelation of gelatin and integration of lysozyme. Gelation yield, specific surface area, macro-porosity and swelling degree of the microcryogels were examined in order to characterize their physical properties. MTT method was utilized to measure cell viability of the gelatin microcryogels with a period of 24, 48 and 72 h
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Endowing polyetheretherketone with anti-inflammatory ability and improved osteogenic ability. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-22 Yue Yu,Kenan Xie,Lu Xie,Yi Deng
Abstract Both osteogenesis and anti-inflammatory bioactive materials play a vital role in the regeneration of skeletal defects. Bone inflammation is hard to cure and can lead to malformation or amputation. The purpose of this study is to use anti-inflammatory drugs to endow polyetheretherketone (PEEK) with the dual ability to achieve anti-inflammatory effects while maintaining favorable biocompatibility
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PEGYLATION: an important approach for novel drug delivery system. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-17 Deepa Yadav,Hitesh Kumar Dewangan
PEGylation is the covalent addition of PEG to one more molecule. PEGylation can improve the maintenance time of the therapeutics similar to proteins, liposomes, and nanoparticle through shielding them beside different debasing mechanisms dynamic in a body that improve beneficial properties. This skill is used to get better half-life and other pharmaceutical properties of a protein, peptide, or non-peptide
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Eco-friendly nanocellulose and its biomedical applications: current status and future prospect. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-15 Poonam Nehra,R P Chauhan
Abstract Cellulose is the earth’s leading natural polymer. It is known for its properties like biocompatibility, high mechanical strength, cost-effectiveness and lightweight. Nanocellulose displays better properties as compared to the native cellulose fibre. The nanocellulose is very remunerative in the arenas of routine application especially in health care, food industry, sanitary products and many
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Effect of surface morphology change of polystyrene microspheres through etching on protein corona and phagocytic uptake. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-14 Bin Chen,Zhengzhong Wu,Meng Tian,Tingting Feng,Chen Yuanwei,Xianglin Luo
Abstract Surface physicochemistry properties of polymer particles are crucial for protein corona formation and macrophage phagocytosis when they contact with living body. In this work, polystyrene microspheres (PS-MSs) were selected as a model of polymer microparticles and fabricated by chromic acid etching through controlling conditions to obtain different surface morphology structures and to investigate
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Regeneration of annulus fibrosus tissue using a DAFM/PECUU-blended electrospun scaffold. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-13 Chen Liu,Liang Xiao,Yu Zhang,Quanlai Zhao,Hongguang Xu
Abstract Low back pain and disc degeneration affect quality of life and imposes an enormous financial burden. Although annulus fibrosus (AF) tissue engineering provides an alternative therapeutic possibility in the treatment of degenerative intervertebral disc disease, it is restricted by the biochemical properties, organizational structure, and mechanical characteristics of the scaffold. The ideal
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Evaluation of a peptide motif designed for protein tethering to polymer surfaces. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-13 Ayana Nakano,Isao Hirata,Binh Vinh Pham,Ajay Shakya,Kotaro Tanimoto,Koichi Kato
Abstract In search for peptide motifs that allow us to efficiently tether fusion proteins onto polymer surfaces, we designed a KLKLKLKLKL (KL5) decapeptide in which basic and hydrophobic amino acids were alternately linked. By means of genetic engineering technology together with a bacterial expression system, the KL5 fusions of epidermal growth factor (EGF), basic fibroblast growth factor, and stromal
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Ternary nano-biocomposite films using synergistic combination of bacterial cellulose with chitosan and gelatin for tissue engineering applications. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-09 Chhavi Sharma,Nishi K Bhardwaj,Puneet Pathak
Ternary nano-biocomposite films of bacterial cellulose-chitosan-gelatin (BC-C-G) were fabricated by immersing the BC pellicles into chitosan and gelatin mixture and subsequently freeze-drying. Scanning electron microscopy (SEM) images of the nano-biocomposite films revealed the presence of interconnected pores, with fibre diameter 20-150 nm. The composite films have a porosity of 95.3%, and showed
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Gentamicin encapsulated within a biopolymer for the treatment of Staphylococcus aureus and Escherichia coli infected skin ulcers. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-08 José Lúcio Pádua Gemeinder,Natan Roberto de Barros,Giovana Sant'Ana Pegorin,Junya de Lacorte Singulani,Felipe Azevedo Borges,Marina Constante Gabriel Del Arco,Maria José Soares Mendes Giannini,Ana Marisa Fusco Almeida,Sérgio Luiz de Souza Salvador,Rondinelli Donizetti Herculano
Abstract Skin wound infection requires carefully long-term treatment with an immense financial burden to healthcare systems worldwide. Various strategies such as drug delivery systems using polymer matrix from natural source have been used to enhance wound healing. Natural rubber latex (NRL) from Hevea brasiliensis has shown angiogenic and tissue repair properties. Gentamicin sulfate (GS) is a broad-spectrum
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Enhanced transfection efficiency of low generation PAMAM dendrimer conjugated with the nuclear localization signal peptide derived from herpesviridae. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-08 Jeil Lee,Yong-Eun Kwon,Younjin Kim,Joon Sig Choi
Abstract Polyamidoamine (PAMAM) dendrimer is an extensively studied polymer in the biomedical research because of its low polydispersity, distinct molecular structure, and surface functionalities. Generally, a high-generational PAMAM dendrimer is used for gene delivery because transfection efficiency is dependent on charge density; however, an increase in charge density induces disruption of the cellular
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Epidermal stimulating factors-gelatin/polycaprolactone coaxial electrospun nanofiber: ideal nanoscale material for dermal substitute. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-08 Li Yan,Haoyu Wang,Hui Xu,Rui Zheng,Zhengyu Shen
Abstract In this study, an ideal nano-scale material, named epidermal stimulating (ES) factors-gelatin/polycaprolactone (GT/PCL) nanofiber, was fabricated using a coaxial electrospinning technique. The ES-GT/PCL nanofibers possessed a highly porous structure with qualified mechanical properties for transplantation. With ES factors stored in the core and GT/PCL in the shell, the ES factors could be
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Polyelectrolytic gelatin nanoparticles as a drug delivery system for the promastigote form of Leishmania amazonensis treatment. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-08 Catarina de Souza,Janicy A Carvalho,Alexandro S Abreu,Lucas P de Paiva,Jéssica A R Ambrósio,Milton Beltrame Junior,Marco A de Oliveira,Josane Mittmann,Andreza R Simioni
Abstract In this study, phthalocianato[bis(dimethylaminoethanoxy)] silicon (NzPC) was loaded onto gelatin nanoparticles functionalized with polyelectrolytes (polystyrene sulfonate/polyallylamine hydrochloride) by layer-by-layer (LbL) assembly for photodynamic therapy (PDT) application in promastigote form of Leishmania amazonensis treatment. The process yield, and encapsulation efficiency were 80.0%
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Fluidic embedding of additional macroporosity in alginate-gelatin composite structure for biomimetic application. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-08 Arindam Banerjee,Subhayan Das,Mahitosh Mandal,Somenath Ganguly
Abstract Biomimetic characteristics of hydrogel scaffold are tuned in this study utilizing the synergy of alginate, gelatin, and microfluidically embedded voids. Superposition of alginate and gelatin polymer networks results in additional rigidity, which can be tuned by introduction of voids, and thereby allowing faster release of pore pressure through movement of aqueous phase through the pore network
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An antibacterial dental light-cured glass-ionomer cement with improved hardness J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-03 Yong Chen; Gulsah Caneli; Rashed Almousa; Xin Wen; Gregory G. Anderson; Dong Xie
Abstract An antibacterial dental light-cured glass-ionomer cement has been developed and evaluated. An antibacterial furanone derivative was synthesized and covalently attached onto the surface of alumina filler particles. The formed antibacterial fillers were then mixed into a light-curable glass-ionomer cement formulation. Surface hardness and bacterial viability were used to evaluate the modified
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Simvastatin enhanced antimicrobial effect of Ag+ against E. faecalis infection of dentine through PLGA co-delivery submicron particles. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-03 Wei Fan,Mengting Duan,Qing Sun,Bing Fan
Abstract Enterococcus faecalis (E. faecalis) is one of the dominant bacteria for refractory infections of teeth. Silver ions (Ag+) have been proved to be a strong bactericide but with high cytotoxicity and discoloration property. Simvastatin is an agent used for dyslipidemia treatment and has anti-inflammatory property. In this study, Ag+ and simvastatin were for the first time used in combination
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Preparation, characterization, and in vitro drug release behavior of thiolated alginate nanoparticles loaded budesonide as a potential drug delivery system toward inflammatory bowel diseases. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-09-03 Muhammad Arif,Zhe Chi,Yong-Jun Liu,Chen-Guang Liu
Abstract For site-specific drug delivery in inflammatory bowel disease, reducible sodium alginate nanoparticles cross-linked with disulfide linkage were developed. Nanoparticles were synthesized in deionized water through self-assembly of amphiphilic thiolated sodium alginate Alg-Cys and subsequently produced cross-linking of disulfide bonds. TEM image showed a spherical core-shell configuration with
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Biomimetic hybrid scaffold of electrospun silk fibroin and pancreatic decellularized extracellular matrix for islet survival. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-08-31 Yi Zhu,Dongzhi Wang,Xihao Yao,Mingming Wang,Yahong Zhao,Yuhua Lu,Zhiwei Wang,Yibing Guo
Islet transplantation is considered as one of the promising treatment options for curing diabetes. However, the extracellular matrix (ECM) is destroyed during the process of islet isolation and extraction, which leads to decreased islet activity in vitro. ECM-based biomaterials which used to reconstruct the microenvironment of cells have been applied in various fields. In this study, an electrospinning
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A dual pH and redox-responsive Ag/AgO/carboxymethyl chitosan composite hydrogel for controlled dual drug delivery. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-07-02 Yanqin Xu,Jie Liu,Shumin Guan,Yuan Cao,Changguo Chen,Dan Wang
A pH and redox dual-responsive composite hydrogel was developed, which was formed from triblock copolymer PEG-SS-PCL-SS-PEG and Ag/AgO/carboxymethyl chitosan (CMCS) hydrogel inclusion complexes. Dithiodipropionic acid and poly(ethylene glycol) (PEG) were esterified to synthesize a hydrophilic segment PEG-SS-COOH polymer containing a disulfide bond, and ε-caprolactone is ring-opened in Ar atmosphere
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An antibacterial dental light-cured glass-ionomer cement with improved hardness J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-08-17 Yong Chen; Gulsah Caneli; Rashed Almousa; Xin Wen; Gregory G. Anderson; Dong Xie
An antibacterial dental light-cured glass-ionomer cement has been developed and evaluated. An antibacterial furanone derivative was synthesized and covalently attached onto the surface of alumina filler particles. The formed antibacterial fillers were then mixed into a light-curable glass-ionomer cement formulation. Surface hardness and bacterial viability were used to evaluate the modified cements
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Keratin-dopamine conjugate nanoparticles as pH/GSH dual responsive drug carriers. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-08-13 Xiao Han,Lijuan Wang,Jinsong Du,Jie Dou,Jiang Yuan,Jian Shen
Abstract Drug-loaded nanoparticles have been widely used in the field of tumor treatment due to their low side effects and reduced frequency of administration. In this study, keratin-dopamine conjugate was first synthesized by amidation reaction and then formed nanoparticles by self-polymerization of dopamine segment. Keratin-dopamine conjugate nanoparticles (KNPs) exhibited pH and glutathione (GSH)
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In vitro study on electrospun lecithin-based poly (L-lactic acid) scaffolds and their biocompatibility. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-08-11 Zhonghua Xu,Peng Liu,Hongyin Li,Mingkui Zhang,Qingyu Wu
Abstract Lecithin is a natural mixture of phospholipids and neutral lipids, and plays a vital role in the maintenance of cell-membrane integrity for all of the basic biological processes.This study aimed to evaluate the adhesion and growth of bone marrow-derived mesenchymal stem cells (BMSCs) on the three-dimensional (3D) electrospun lecithin-containing poly (L-lactic acid) (PLLA) fibrous scaffolds
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IL-4 functionalized titanium dioxide nanotubes modulate the inflammatory response of macrophages. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-08-10 Xufeng Yan,Ke Shen,Qiang Tang,Xingtang Fang,Chunlei Zhang,Zhaojing Zhu,Yanhua Hou,Min Lai
Abstract Inflammatory response is an essential part of optimal tissue-implant integration and the regeneration process. Due to their highly plastic properties, macrophages display phenotypic changes during inflammatory signaling. Investigating these changes on implant surfaces is essential for evaluating implant stability and longevity. In order to control macrophage polarization, IL-4 was conjugated
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Near-infrared triggered on-demand local anesthesia using a jammed microgels system. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-08-04 Qiying Pang,Jia Zhao,Shuchi Zhang,Xiaoqing Zhang
Abstract To conveniently modulate the degree of local analgesia in response to changes in patients’ needs and level of activity, a NIR-activated drug delivery system based on jammed microgels was introduced in the present study to realize on-demand local anesthesia. Chemically cross-linked gelatin microgels (5–15 μm) containing N-isopropylacrylamide (NIPAM), methylallyl polyethylene glycol (APEG) and
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Design and investigation of salecan/chitosan hydrogel formulations with improved antibacterial performance and 3D cell culture function. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-08-02 Zhiping Fan,Ping Cheng,Dawei Wang,Yanna Zhao,Zhengping Wang,Jun Han
Abstract Hydrogel formulations are considered to be promising dosage forms for clinical delivery of antibiotics but suffer from many limitations such as polymers selection and crosslinking methods. Herein, dynamic Schiff base reaction crosslinked hydrogels (denoted as CO) with ‘switchable’ channels were designed based on Chitosan and Salecan. Chitosan maintains the pH sensitive property while providing
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PLinaS-g-PEG coated magnetic nanoparticles as a contrast agent for hepatocellular carcinoma diagnosis. J. Biomater. Sci. Polym. Ed. (IF 2.69) Pub Date : 2020-05-27 Zeynep Karahaliloglu,Ebru Kilicay,Baki Hazer
Among many different types of fabricated nanoparticles, magnetic iron oxide nanoparticles (MNPs) have unique physical and chemical properties and have been widely used due to theirs enhanced permeability and retention effect for biomedical applications. The incorporated theranostic MNPs into biopolymer coatings are currently particular interest to investigators in the fields of nanobiomedicine because