Among many different types of fabricated nanoparticles, magnetic iron oxide nanoparticles (MNPs) have unique physical and chemical properties and have been widely used due to theirs enhanced permeability and retention effect for biomedical applications. The incorporated theranostic MNPs into biopolymer coatings are currently particular interest to investigators in the fields of nanobiomedicine because

Drug-loaded nanoparticles have been widely used in the field of tumor treatment due to their low side effects and reduced frequency of administration. In this study, keratin-dopamine conjugate was first synthesized by amidation reaction and then formed nanoparticles by self-polymerization of dopamine segment. Keratin-dopamine conjugate nanoparticles (KNPs) exhibited pH and glutathione (GSH) dual responsiveness

For site-specific drug delivery in inflammatory bowel disease, reducible sodium alginate nanoparticles cross-linked with disulfide linkage were developed. Nanoparticles were synthesized in deionized water through self-assembly of amphiphilic thiolated sodium alginate Alg-Cys and subsequently produced cross-linking of disulfide bonds. TEM image showed a spherical core-shell configuration with a size

Lecithin is a natural mixture of phospholipids and neutral lipids, and plays a vital role in the maintenance of cell-membrane integrity for all of the basic biological processes.This study aimed to evaluate the adhesion and growth of bone marrow-derived mesenchymal stem cells (BMSCs) on the three-dimensional (3D) electrospun lecithin-containing poly (L-lactic acid) (PLLA) fibrous scaffolds. In this

Compared with the traditional chemotherapy by injection, local release of drugs in the lesion area is a more efficient and less harmful treatment for solid tumors. However, the selection of appropriate drug carrier and controlled release of chemotherapy drugs are still great challenges. Herein, a kind of dual-encapsulated three-dimensional (3D) scaffold is designed for local drug release via blending

Hydrogel scaffolds are explored as efficient methods to repair damaged organs or tissues. In this study, we developed a hybrid hydrogel system based on collagen (Col) and PEG-derived polymer (PEGF) for biomedical scaffold. The Col-PEGF hybrid hydrogel, in which different materials were combined and sequential interpenetrating networks were built, achieved significantly enhanced mechanical strength

Bioactivity modification helps polymethylmethacrylate (PMMA) bone cement to reinforce its interfacial adhesion to bone tissues through the chemical bonding of apatite. Since Si-OH groups combined with Ca2+ ions have succeeded in inducing apatite formation, more combinations of functional groups and active ions are being explored. In this study, Bis[2-(methacryloyloxy)ethyl] phosphate (B2meP) containing

Surface modification of titanium implants by siRNA is quite efficient for improving implant osseointegration. Loading siRNA onto their surface is a crucial factor for siRNA-functionalized implants to realize their biological function. Direct binding of siRNA to implants has low siRNA binding and releasing rate, so usually it needs to be mediated by vectors. Polymeric, nonmaterial-mediated and lipid-based

Scaffolding system plays an important role in the development of artificial bone for treatment of defective or diseased bone tissue. In the present work, we have developed microspheres (COS-Ag-Alg-HA) containing chitooligosaccharide (COS) coated silver nanoparticles (Ag NPs) with alginate (Alg) and hydroxyapatite (HA) as bone graft substitutes. The developed microspheres were characterized through

Hydrogel formulations are considered to be promising dosage forms for clinical delivery of antibiotics but suffer from many limitations such as polymers selection and crosslinking methods. Herein, dynamic Schiff base reaction crosslinked hydrogels (denoted as CO) with “switchable” channels were designed based on Chitosan and Salecan. Chitosan maintains the pH sensitive property while providing functional

To conveniently modulate the degree of local analgesia in response to changes in patients’ needs and level of activity, a NIR-activated drug delivery system based on jammed microgels was introduced in the present study to realize on-demand local anesthesia. Chemically cross-linked gelatin microgels (5-15 μm) containing N-isopropylacrylamide (NIPAM), methylallyl polyethylene glycol (APEG) and graphene

The fabrication of molecularly imprinted nanoparticles (MIP-NPs) specific for myoglobin by using thiol-ene photopolymerization in miniemulsion was described. Allyl derivatives of phenylalanine as a functional monomer was synthesized and copolymerized with acrylic monomers via miniemulsion polymerization to produce NIP-NPs with approximately 74 nm number average particle diameter. FTIR and 1H-NMR analysis

Inflammatory response is an essential part of optimal tissue-implant integration and the regeneration process. Due to their highly plastic properties, macrophages display phenotypic changes during inflammatory signaling. Investigating these changes on implant surfaces is essential for evaluating implant stability and longevity. In order to control macrophage polarization, IL-4 was conjugated to titanium

It has been demonstrated an increase in resistance of Candida albicans to conventional therapies, probably, due the indiscriminate use of the conventional antifungal drugs. In this aspect, the nanotechnology generates the possibility of creating new therapeutic agents. Thus, the objective of this paper was to produce and characterize a bovine serum albumin (BSA) nanoparticle encapsulated with Methylene

In this study, elastic styrene–butadiene–styrene (SBS), non-elastic SBS and their blends at different ratios were electrospun into fibrous membranes and their cell biocompatibility was evaluated. The as-spun fibers showed an average fiber diameter of 2 µm, and the fibrous membranes had pore size of 8 ± 0.01 µm. The blending ratios of the elastic with non-elastic SBSs showed little effect on fibrous

Cellulose, a polysaccharide of β (1–4) linked D-glucose units, is a cheap, eco-friendly and most abundant natural polymer on this planet. Among various cellulosic materials, cotton cellulose is readily available, lignin-free, FDA approved, and widely used in the medical field because of its higher degree of biocompatibility and non-cytotoxic nature. Though cotton cellulose showed essential material

Acidic tumor microenvironment has been extensively explored to design pH-responsive paclitaxel prodrug micelles for cancer therapy. The object of this study is to investigate the pH-responsive drug release behavior and the anti-proliferation capacity of acetal-linked paclitaxel polymeric prodrug micelles. The prodrug was synthesized and evaluated for paclitaxel content. The prodrug micelles were fabricated

Microbial adhesion reduction as well as platelet compatibility improvement have been suggested as the key requirements for developing blood-contacting synthetic biomaterials. Surface grafting of hydrophilic polyethylene glycol chains or alkyl chains with zwitterionic terminal ends has been proposed for reducing microbial or platelet adhesion. Nonetheless, none has been reported to incorporate both

Here we demonstrate a type of pH and redox dual-responsive micelles, which were self-assembled in aqueous solution by an amphiphilic polymer, methoxypoly(ethylene glycol)-cystamine-poly(L-glutamic acid)-imidazole (mPEG-SS-PGA-IM). Considering tumor cells or tissues exhibiting low pH values and high glutathione (GSH) concentration, mPEG-SS-PGA-IM micelles possessed the charge conversion at pH of tumor

Micro-hierarchical structured shellac films were prepared using a solution casting method with dodecyltrichloro-immobilized shellac microparticles. We evaluated two opposite surfaces of the shellac films—one a micro-hierarchical structured side and the other a neutralized shellac side using alkali ethanol—for their applications in the medical field. A bending strength test using a tensile strength

Nano-drug delivery system (NDDS) has attracted widespread attention for their controlled drug release. In this work, keratin nanoparticles (KNPs) were prepared by self-crosslinking. No toxic chemical crosslinkers were added in the whole procedure. The morphology and size of KNPs were tested by transmission electron microscopy (TEM) and dynamic light scattering (DLS), respectively. The KNPs exhibited

The efficacy and safety of photodynamic therapy (PDT) have drawn much attention from clinicians and researchers in the field of anticancer treatments since the last century. Despite the numerous positive outcomes, the works on PDT have brought to light over the last decades, much room remains for improvements in PDT tools, mainly on the photosensitizer molecules. This work reports the first experiments

Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery. In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule. The phase inversion method was successfully used to prepare molecularly

Collagen type II (CT-II) has unique biological activities and functions, yet the knowledge on amphibian-derived CT-II is rare. Herein, acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC) were successfully isolated and characterized from the cartilage of Chinese Giant Salamander (CGS). The in vitro immunogenicity of collagen was then evaluated and compared with that of the standard bovine

The combination of hyperthermia and chemotherapy has a potential synergic effect in antitumor activity. The development of new biocompatible and biodegradable polymers to simultaneously encapsulate magnetic nanoparticles (MNPs) and antitumoral drugs offer new cancer treatment opportunities. Here, biodegradable and biocompatible poly(thioether-ester) (PTEe) was used to encapsulate MNPs and 4-nitrochalcone

Chitosan adhesive hydrogels have attracted interest because of their unique properties. However, it is still a challenge to use simple and unmodified chitosan to synthesize multifunctional hydrogels with adhesive, self-healing and strain sensing properties. Here, a multifunctional hydrogel of Ca2+-chitosan/polyacrylamide（Ca2+- CS/PAAm）with adhesive self-healing and strain sensing properties was carried

A pH and redox dual-responsive composite hydrogel was developed, which was formed from triblock copolymer PEG-SS-PCL-SS-PEG and Ag/AgO/carboxymethyl chitosan (CMCS) hydrogel inclusion complexes. Dithiodipropionic acid and poly(ethylene glycol) (PEG) were esterified to synthesize a hydrophilic segment PEG-SS-COOH polymer containing a disulfide bond, and ε-caprolactone is ring-opened in Ar atmosphere

Poly (vinyl alcohol) (PVA) hydrogel has been considered as promising cartilage replacement materials due to its excellent characteristics such as high water content, low frictional behavior and excellent biocompatibility. However, lack of sufficient mechanical properties and cytocompatibility are two key obstacles for PVA hydrogel to be applied as cartilage substitutes. Herein, Polyacrylic acid (PAA)

The emerging polymer nanocomposites have received industrial interests in diverse fields because of their added value in metal oxide-based nanocomposites, such as titanium (TiO2) and zinc oxide (ZnO). Linear low-density polyethylene (LLDPE)-based polymer has recently generated a huge market in the healthcare industry. TiO2 and ZnO are well known for their instant photocatalytic killing of hospital-acquired

Biomedical devices trigger immune responses when implanted in the body, as they are treated as foreign bodies. To avoid inflammatory responses and enhance the biocompatibility of biomedical devices, advanced coating technology that can modulate immune responses is essential. As a part of the immune response in the body, autologous cells evade attack from macrophages using CD47 ligands that function

Nanoparticles (NPs) have been studied for a wide variety of applications, due to the elevated surface area and outstanding properties. Several types of NPs are available nowadays, each one with particular characteristics and challenges. Bionanocomposites, especially composed by polymer matrices, are gaining attention in the biomedical field. Although, several studies have shown the potential of adding

Poly(zwitterions) polymer brushes were fabricated by surface-initiated atom transfer radical polymerization (SI-ATRP) on PVA substrate. The results of XPS and FTIR proved the successful graft of CBMA and SBMA to PVA. The surface of the PVA films would be rougher after the functionalization. Its hydrophilicity increased dramatically and the water contact angle decreased from 45.2° to 7.2°. The visible

Most chemotherapeutic drugs commonly suffer from low aqueous solubility that can potentially limit drugs absorption. Drug nanomerization is an advanced approach to overcoming their poor water-solubility. In this study, class I hydrophobin recombinant HGFI (rHGFI)-based curcumin (Cur) nanoparticles (rHGFI-Cur) were prepared by freeze-drying method. The rHGFI-Cur nanocomposites were characterized by

Minimally invasive implantation of porous implants with large volume for in vivo filling proposes high requirements for material preparation. Porous scaffolds based on shape memory polymer (SMP) possess great potential for being delivered as the compact form via minimally invasive surgery. Here, poly (ε-caprolactone)-dienes (PCL-dienes) and crylic acid (AA) were polymerized and cross-linked to fabricate

This study aims to achieve the principles of tissue engineering using biopolymers to be applied in the field of vital endodontic treatment to stimulate stem cells and engineering and regeneration of dentin tissue. the polymer blend was loaded with the steroidal anti-inflammatory drug, dexamethasone, and the porous drug-loaded bio-sponge was produced by lyophilization. Bio-sponge, as a direct pulp capping

The aim of this study was an in-situ synthesis of hydroxyapatite (HA) on cellulose fibers to be used as a new reinforcing agent for dental restorations. The microwave irradiation method was used for synthesis and the materials were characterized with analytical techniques. The prepared dental resin composites were mechanically tested by a universal testing machine and electrodynamic fatigue testing

Nasal injury following nasal surgery is an adverse consequence, and prompt treatment should be initiated. Nasal packing, either non-absorbable or absorbable, are commonly used after nasal surgery to prevent bleeding and promote wound healing. In the current study, a novel gelatine sponge crosslinked with genipin was evaluated for suitability to be used as nasal packing and compared to one of the frequently

Under solvothermal conditions, two new coordination polymers (CPs), namely {[Cu(HL)]·2CH3CN}n (1) and {[Cu(HL)(bimb)]·4H2O}n (2) (H3L = tris(p-carboxyphenyl)phosphane oxide, bimb = 1,4-bis(imidazol-1-ylmethyl)benzene) were prepared. Their treatment activity on the human prostate cancer was evaluated through series of biological experiments. Firstly, the human prostate cancer cells proliferation was

Multi-stimuli- responsive mechanical strong stretchable hydrogel has grabbed extensive attention in recent years. Here, a novel stretchable conductive biocompatible near-infrared light(NIR)-/thermal-/pH-/ionic concentration- responsive carboxymethyl chitosan (CMCTs)/graphene oxide (GO)/poly(N-isopropylacrylamide)(PNIPAm) nanocomposite double network hydrogel was fabricated through a simple one-pot

In this study, poly(ε-caprolactone) (PCL) has been blended with a more hydrophilic poly(ethylene glycol) (PEG) and with a biocompatible block-co-polymer: poly(L-lactide-co-ε-caprolactone-co-glycolide) (PLCG) in order to improve hydrophilicity, biocompatibility and biodegradability of PCL. PCL and the blend solutions were subjected to electrospinning to produce nanofiber scaffolds by the addition of

The main objective of this study was to develop an appropriate interpenetrating polymer network (IPN) particulate system from water-soluble polymers such as sodium alginate (NaAlg), poly (vinyl alcohol) (PVA) and methyl cellulose (MC) for the controlled release of flurbiprofen (FBP), a non-steroidal anti-inflammatory drug. Therefore, polymeric IPN beads containing FBP were prepared by crosslinking

The replacement therapy or transplantation using neural cells, which differentiated from stem cells, has emerged as a promising strategy for repairing damaged neural tissues and helping functional recovery in the treatment of neural system diseases. The challenge, however, is how to control embryonic stem cell fate so that neural differentiation can be efficiently directed to enrich a neuron cell population

Surgical resection in tongue cancer can impair speech and swallowing, reducing quality of life. There is a need for biomaterials that can regenerate tongue muscle tissue defects. Ideally, such a biomaterial would allow controlled release of therapeutic proteins, support the survival and differentiation of therapeutic cells, and promote tongue muscle regeneration in vivo. The aim of the current study

The vascularization within the scaffold is still a significant challenge in tissue engineering applications. Sulfated chitosan (SCS) as an amazing substance have been used in tissue engineering to stimulate angiogenesis. However, it is not clear whether they have difference in the ability to promote vascularization of SCS with different sulfonic acid group sites. The aim of this study was to evaluate

Currently, conjunctivitis is treated using ofloxacin eye drop solution, which shows low bioavailability and patient non-compliance. Ofloxacin loaded contact lens can be used to overcome the issues related to eye drop solutions (i.e. low bioavailability and frequent instillation). However, the conventional soaking method shows poor ofloxacin uptake and significantly affect the swelling and optical properties

We report the efforts to construct active targeting quantum dots using receptor-binding peptide for enhanced detection and migration inhibition of cancer cells. Peptide E5 has specific binding with chemokine receptor 4 (CXCR4), which is a transmembrane G-coupled receptor involved in the metastasis of various types of cancers. E5 was introduced to the surface of CdSe/ZnS quantum dots via biotin-streptavidin

The bionanocomposite hydrogels based on polyvinyl alcohol and egg white (as the matrix) and montmorillonite nanoclay (as reinforcement) were fabricated via the freezing-thawing technique. The prepared bionanocomposite hydrogels were loaded with clindamycin, as an effective antibiotic, to attain new potential wound dressings for healing the infected wounds. The microstructural properties of the bionanocomposite

The biodegradable material poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) scaffold has good biodegradability, but poor biocompatibility limits its application in the biological field. And it can effectively improve its biological activity by compounding with the bone conduction activity material of Barium titanate (BT). The PHBV and piezoelectric material BT were prepared into porous composite

The reconstruction of the nerve tissue engineering scaffold is always of particular interest due to the inability to recover and repair neural tissues after being damaged by diseases or physical injuries. The primary purpose of this study was obtaining a model used to predict the diameter of the fibers of electrospun polyhydroxybutyrate (PHB) scaffolds. Accordingly, the range of operating parameters

The long circulation time and targeting drug delivery at tumor sites are still the main challenges of nanodrug delivery systems for antitumor activity. Herein, a cancer cell membrane-coated biomimetic nanodrug delivery system was fabricated. The paclitaxel (PTX)-loaded poly(lactic acid) (PLA) nanoparticles (PPNs) were used as the inner cores and 4T1 cancer cell membranes were coated on the surface

A novel bilayer fibrous membrane for guided tissue regeneration (GTR) was prepared via two-step electrospinning process, subsequent crosslinking and surface conjugation with heparin. The bilayer membrane consists of upper layer polycaprolactone/gelatin (PCL/Gel) membrane for soft tissue regeneration and lower layer PCL/Gel/nano-hydroxyapatite (PCL/Gel/n-HA) membrane for hard tissue regeneration. The

Small-caliber artificial blood vessels with inner diameters of smaller than 4 mm have not been put into practical use because of early thrombus formation and graft occlusion. To realize small-caliber artificial blood vessels with anti-thrombus property and long-term patency, one of the promising approaches is endothelialization of the lumen by tissue engineering approaches. Integrin α4β1 on the endothelial

Recently several scientific-technological advances in the health area have developed. Among them, we can highlight research addressing nanoscience and nanotechnology focusing on the development of formulations for the cancer treatment. This work describes the synthesis and characterization of bovine serum albumin (BSA) polyelectrolytic nanoparticles for controlled release using silicon dihydroxide

Lethal hemorrhage could endanger lives. Although many hemostatic agents are commercially available with good clinical effect, it is necessary to develop novel hemostatic materials with high efficacy, biological safety, low cost, easily preparation and excellent biodegradability and biocompatibility. Here, novel biodegradable and uniform microspheres with regular spherical architecture and porous microstructure

Herein, we construct a charge - switchable polymer nano micelles poly (2-(hexamethyl eneimino) ethyl methacrylate) - b - poly (ethylene glycol) monomethyl ether methacrylate) - b - poly (diethyl enetriaminepentaacetic acid methacrylate) - b - poly (1-vinyl imidazole) - b - poly (4-vinyl phenylboronic acid) (PC7A-PEG-DTPA-VI-PBA) in different pH solutions. DOX released faster from micelles in a weakly

Electrospinning is a common and effective technology used for the fabrication of biomimetic nanofibers targeting tissue regeneration applications. As for cartilage regeneration, nanofibers containing natural components derived from cartilage extracellular matrix (ECM) are preferred. However, it is not easy an task to electrospin glycosaminoglycan (GAG) like hyaluronic acid (HA) and chondroitin sulfate

The novelty of the work lies in the creation and study of the physical and biological properties of biodegradable polymer coatings for stents based on poly(lactic-co-glycolic acid) (PLGA). Polymer coatings are capable of prolonged and directed release of molecules with a high molecular weight, in particular, protein molecules of prourokinase (m.w. 54 kDa). A technology has been developed to create

Body membranes are thin sheets/layers of cells or tissues which cover the surface of internal organs, the outside of the body and lines various body cavities. These membranes are separated into two main groups which are epithelial membranes and connective tissue membranes. Decellularized forms of inner body membranes in the groups of epithelial membranes (amniotic membrane, mesentery, omentum, pericardium

Beaded nanofiber is a promising fibrous structure could act as drug delivery system with sustained drug release for regulating cell behaviors used in tissue engineering. Poly (L-lactic acid-co-ε-caprolactone) (PLCL) beaded nanofiber with core-shell structure (130 ± 30 nm) was fabricated and bovine serum albumin (BSA) was encapsulated into the inner layer. The surface morphology and characteristic were

Silk fibroin (SF) porous scaffolds provide mechanical support and biochemical signals to encourage cell attachment and modify biological performance. The available methods for the preparation of SF scaffolds are still required. The crosslinkers used are likely to impact the biocompatibility. Herein, water-insoluble SF scaffolds were prepared by physical methods. The phosphate solution promoted SF molecules