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  • Tumor-targeted and stimuli-responsive nanoplatform with cascade activities for multiple model tumor therapy
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-15
    Ronghua Jin; Jirong Xie; Xiaoshan Yang; Yu Tian; Pingyun Yuan; Yongkang Bai; Shiyu Liu; Bolei Cai; Xin Chen

    The contradiction between normal tissues damage caused by strong photothermal/chemo therapy and invalid tumor treatment caused by gentle photothermal/chemo therapy is still a great challenge. Therefore, development of new therapeutic system to selectively destruct tumors under gentle but effective photothermal/chemo therapy would be a promising strategy for clinical treatment. Herein, a rambutan-like nanocomplex (PDA-SNO-GA-HA-DOX, PSGHD for short) with tumor selective accumulation, pH-triggered doxorubicin (DOX) release, near infrared light (NIR) dependent nitric oxide release, NIR dependent photothermal conversion and HAase-induced gambogic acid (GA) release was fabricated for effective and accurate tumor treatment, which consists of S-nitrosothiol-functionalized polydopamine (PDA-SNO) core and gambogic acid derivatized hyaluronic acid (HA-GA) shell with doxorubicin (DOX) as cargos. The as-synthesized PSGHD nanocomplex exhibited different kinetics for the release of both DOX (agent for chemotherapy) and GA (agent for enhancing thermal damage) under different simulated physiological conditions, where the release of DOX was highly pH dependent and the release of GA could only be triggered by HAase, indicating its good responsiveness to tumor environment (Low pH and rich of HAase) as design. When the PSGHD nanocomplex was exposed under 808 nm NIR radiation, it further performed excellent photothermal conversion, which resulted in rise of local temperature over 50 oC and controllable conversion of SNO to nitric oxide (NO, agent for reducing drug-efflux). Moreover, due to the HA section, PSGHD nanocomplex could be rapidly and selectively internalized by tumor cells instead of healthy cells in 12 h co-incubation. Based on the tumor targeting, stimuli-responsive DOX/GA release, photothermal conversion and NIR triggered NO generation, the PSGHD nanocomplex simultaneously achieved both tumor specific low-drug-efflux chemotherapy and low-temperature photothermal therapy, resulting in an eight-fold apoptosis of tumor cells over normal cells under NIR radiation. In vivo data from mouse models further showed that the PSGHD nanocomplex could completely inhibit the tumor growth and significantly prolonged the survival rate of tumor bearing mice in 50 days, demonstrating the high efficiency of the PSGHD nanocomplex for tumor therapy.

    更新日期:2020-01-15
  • Ultra-fast and universal detection of Gram-negative bacteria in complex samples based on colistin derivatives
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-14
    Jea Sung Ryu; San Hae Im; Yoo Kyung Kang; Yang Soo Kim; Hyun Jung Chung

    Gram-negative bacteria are a significant cause of infections acquired in both hospital and community settings, resulting in a high mortality rate worldwide. Currently, a Gram-negative infection is diagnosed by symptom evaluation and is treated with empiric antibiotics which target both Gram-negative and Gram-positive bacteria. A rapid and simple diagnostic method would enable immediate and targeted treatment, while dramatically reducing antibiotic overuse. Herein, we introduce a method utilizing a fluorescent derivative of colistin (COL-FL), that can directly label the Gram-negative cell wall of live bacteria and universally detect the targets within 10 min. By using the COL-FL assay, we achieved the differential labeling of various Gram-negative pathogens related to hospital-acquired infections, which could be subsequently detected via spectrofluorometry and microscopy. Further, we determined that our method can be used for complex samples, such as combinations of multiple bacterial types; bacteria in the presence of mammalian cells; and bacteria with serum components. This assay can be integrated into a simple diagnostic platform for rapid screening tests and the stratification of Gram-negative bacterial infections in the clinic.

    更新日期:2020-01-15
  • Duo of (–)-epigallocatechin-3-gallate and doxorubicin loaded by polydopamine coating ZIF-8 in the regulation of autophagy for chemo-photothermal synergistic therapy†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-17
    Xuerui Chen; Rongliang Tong; Bingbing Liu; Hua Liu; Xiaode Feng; Shiping Ding; Qunfang Lei; Guping Tang; Jian Wu; Wenjun Fang
    更新日期:2020-01-15
  • Dextran-based tube-guides for the regeneration of the rat sciatic nerve after neurotmesis injury†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-23
    Ana Catarina Pinho; Mariana Vieira Branquinho; Rui Damásio Alvites; Ana Clotilde Fonseca; Ana Rita Caseiro; Sílvia Santos Pedrosa; Ana Lúcia Luís; Isabel Pires; Justina Prada; Luísa Muratori; Giulia Ronchi; Stefano Geuna; José Domingos Santos; Ana Colette Maurício; Arménio Coimbra Serra; Jorge Fernando Jordão Coelho
    更新日期:2020-01-15
  • Multifunctional hybrid nanoconstructs facilitate intracellular localization of doxorubicin and genistein to enhance apoptotic and anti-angiogenic efficacy in breast adenocarcinoma†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-21
    Ravi Prakash Shukla; Jayant Dewangan; Sandeep Urandur; Venkatesh Teja Banala; Monika Diwedi; Shweta Sharma; Sristi Agrawal; Srikanta Kumar Rath; Ritu Trivedi; Prabhat Ranjan Mishra
    更新日期:2020-01-15
  • Hierarchically structured hydrogels utilizing multifunctional assembling peptides for 3D cell culture†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-16
    Amber M. Hilderbrand; Eden M. Ford; Chen Guo; Jennifer D. Sloppy; April M. Kloxin
    更新日期:2020-01-15
  • Correction: A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-14
    Xumei Ouyang; Xiaoling Wang; Heinz-Bernhard Kraatz; Soha Ahmadi; Jianqing Gao; Yuanyuan Lv; Xiaoyi Sun; Yongzhuo Huang

    Correction for ‘A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis’ by Xumei Ouyang et al., Biomater. Sci., 2020, DOI: 10.1039/c9bm01401b.

    更新日期:2020-01-14
  • Efficient reduction of fibrous capsule formation around silicone breast implants densely grafted with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers by heat-induced polymerization†
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-14
    Sunah Kang; Jungah Kim; Seulah Kim; Maierdanjiang Wufuer; Sohyun Park; Youngmin Kim; Dongkil Choi; Xian Jin; Yumin Kim; Yan Huang; Byoungjun Jeon; Tae Hyun Choi; Ji-Ung Park; Yan Lee
    更新日期:2020-01-14
  • Hyaluronic acid/Lysozyme self-assembled coacervate to promote cutaneous wound healing
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-14
    Xiaoye Zhao; Lin Wang; Jushan Gao; Xi Chen; Ke Wang

    Traditional hydrogel dressings are limited in practical applications due to the complexity of the preparation and low biocompatibility. So It has an urgent need to design wound dressing with simple preparation method, higher biocompatibility, and superior therapeutic effect. Additionally, using a polysaccharide/protein mixture system is an attractive method to prepare gel. In this study, simple mixture of hyaluronic acid/ lysozyme (HL) was used to obtain HL coacervate gel. HL coacervate has suitable viscoelasticity, excellent adhesion on skin tissue. We demonstrated its high-efficiency self-healing property to overcome fracture or deformation. HL coacervate showed a significant effect on promoting wound healing in full-thickness skin defect model. Compared to commercial 3M dressing, it has faster epithelial tissue regeneration and stronger collagen deposition. In addition, cytotoxicity and organ toxicity tests indicated high safety of it. In summary, HL coacervate has broad clinical application prospects as a wound dressing.

    更新日期:2020-01-14
  • N-Oxide Polymer-Cupric Ion Nanogels Potentiate Disulfiram for Cancer Therapy
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-14
    Youqing Shen; Yin Zhong; Rui Sun; Yu Geng; Quan Zhou; ying Piao; Tao Xie; Ruhong Zhou

    Disulfiram (DSF) exerts potent anticancer activity via the formation of chelates with copper or zinc ions in tumor tissues, but the low abundance of these ions in the tumor cannot sustain its antitumor activity. Herein, we show that a zwitterionic water-soluble N-oxide polymer, poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] (OPDMA), can complex cupric ions and form nanogels (OPDMA/Cu2+), which efficiently deliver Cu2+ to tumor tissue to significantly potentiate DSF for effective antitumor therapy.

    更新日期:2020-01-14
  • Microfluidics for ZnO Micro-/Nanomaterials Development: Rational Design, Controllable Synthesis, and On-Chip Bioapplications
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-14
    Nanjing Hao; Michael Zhang; John X. J. Zhang

    Zinc oxide (ZnO) materials hold great promise in diverse applications due to their attractive physicochemical features. Recent years, especially in the last decade, have witnessed a considerable progress toward rational design and bioapplications of multiscale ZnO materials through microfluidic techniques. Design of microfluidic device that allows for precise control over reaction conditions could not only yield ZnO particles with fast production rate and high quality, but also permit downstream applications with desirable and superior performance. This review summarizes microfluidic approaches for the synthesis and applications of ZnO micro-/nanomaterials. In particular, we discuss recent achievement of using microfluidic reactors in the controllable synthesis of ZnO structures (wire/rod, sphere, flower, sheet/flake, and spindle/ellipsoid), and highlight the unprecedented opportunities for applying them in biosensing, biological separation, and molecular catalysis applications through microfluidic chips. Finally, major challenges and potential opportunities are explored to guide future studies in this area.

    更新日期:2020-01-14
  • The effect of metal ions on endogenous melanin nanoparticles used as magnetic resonance imaging contrast agents†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-01
    Anqi Chen; Jinghua Sun; Shijie Liu; Liping Li; Xiaoyang Peng; Lixin Ma; Ruiping Zhang
    更新日期:2020-01-14
  • Microenvironment-activated nanoparticles for oxygen self-supplemented photodynamic cancer therapy†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-10-30
    Hang Liu; Wei Jiang; Qin Wang; Jinxing Xia; Wenhao Yu; Yucai Wang; Yanmei Wang
    更新日期:2020-01-14
  • Regulation of decellularized matrix mediated immune response
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-13
    Juhi Chakraborty; Subhadeep Roy; Sourabh Ghosh
    更新日期:2020-01-13
  • Biomimetic polymeric nanoparticle-based photodynamic immuno-therapy against primary and distant tumors
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-10
    Dongyoon Kim; Junho Byun; Jinwon Park; Yeon Lee; Gayong Shim; Yu-Kyoung Oh

    In this study, we aimed to design a bionanomaterial that could exert anticancer effects against primary and distant tumors via photodynamic immunotherapy. As a biomaterial, we used an amphiphilic phenylalanine derivative of poly gamma glutamic acid, which forms nanoparticles (AN) by self-assembly. For anticancer effects, we co-entrapped hydrophobic chlorin e6 and monophosphoryl lipid A in the core of the AN, to generate M/C/AN. For comparison, we used plain AN and chlorin e6-loaded AN (C/AN). In vitro studies showed that B16F10 cancer cells treated with C/AN or M/C/AN generated reactive oxygen species and exhibited enhanced surface display of calreticulin upon exposure to 660-nm light irradiation. C/AN and M/C/AN exerted similar photodynamic anticancer effects; however, M/C/AN, but not C/AN, induced in vitro dendritic cell maturation. Our biodistribution study revealed that C/AN and M/C/AN showed higher accumulation at the tumor tissues compared to that seen in the free chlorin e6-treated group. In B16F10 tumor-bearing mice, the intravenous injection of C/AN or M/C/AN showed similar photodynamic anticancer effects against primary tumors. However, the growth of distant tumors was more significantly inhibited in the M/C/AN group compared to the C/AN group. At day 40 after inoculation of the primary tumor, MC/AN-treated mice showed 100% survival, whereas the other groups showed 0% survival. In the tumor microenvironment, higher infiltration of CD8 T cells was observed in the M/C/AN group compared to the other groups. Our results suggest that AN co-loaded with a photosensitizer and an immune stimulant may hold great potential to confer photodynamic immunotherapy to inhibit both primary and distant tumors.

    更新日期:2020-01-10
  • Implantation of a functional TEMPO-hydrogel induces recovery from rat spinal cord transection through promoting nerve regeneration and protecting bladder tissue
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-10
    Yu Zhang; Liming Li; Jiafu Mu; Jiachen Chen; Shiqing Feng; Jian-Qing Gao

    Spinal cord injury is one of the most serious traumatic diseases. Current available clinical therapies are unable to provide effective recovery of nerve functions. Implantation of biomaterial scaffolds is a promising approach to bridge the damaged nerve tissue in absence of extracellular matrix. However, the treatments have been impaired by the increased generation of reactive oxygen species in the microenvironment of acute spinal cord injury. Efficient delivery of antioxidant and biocompatible materials and reagents has been a challenge. Herein, a novel hyaluronic acid (HA) hydrogel functionalized with the antioxidant compound 2,2,6,6-tetramethylpiperidinyloxy (TEMPO) is fabricated for nerve tissue regeneration after serious spinal cord transection in rats. TEMPO is tethered onto HA chains to form HA-TEMPO through Schiff Base reaction between 4-Amino-TEMPO and aldehyde modified HA chains. The TEMPO-hydrogel is constructed with highly porous three-dimensional structure via the gelation between the residue aldehydes in HA-TEMPO and the amines in adipic dihydrazide modified HA. The functional TEMPO-hydrogel exhibits antioxidant effect in H2O2 simulated in vitro peroxidative microenvironment. Implantation of the functional hydrogel in vivo induces a significant motor function restoration, which could attributed to the effective functions of the TEMPO-hydrogel in tissue reconnection as well as nerve fiber regeneration of the central nervous spinal cord tissue. Importantly, the treatment of the TEMPO-hydrogel effectively protects the bladder tissue from neurogenic damages. Therefore, the functional TEMPO-hydrogel provides a promising strategy for therapies of central nervous system diseases through the antioxidant as well as lesion-bridging regulation of pathological microenvironment.

    更新日期:2020-01-10
  • A shear-thinning electrostatic hydrogel with antibacterial activity by nanoengineering of polyelectrolytes†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-30
    Yanhui Zhu; Qiaojie Luo; Hongjie Zhang; Qiuquan Cai; Xiaodong Li; Zhiquan Shen; Weipu Zhu
    更新日期:2020-01-10
  • Bioinspired surfaces with wettability: biomolecules adhesion behaviors
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-09
    Haifeng Fan; Zhiguang Guo

    Surface wettability plays an important role in regulating biomolecules adhesion behaviors. The biomolecules adhesion behaviors of superwettable surfaces have become an important topic as an important part of the interactions between materials and organisms. In addition to general research on the moderate wettability of surface, the studies of biomolecules adhesion behaviors extend to extreme wettability ranges such as superhydrophobic, superhydrophilic and slippery surfaces which exhibits both fundamental and practical interests. In this review, we summarize the recent process of biomolecule adhesion behaviors on superwettable surfaces, especially superhydrophobic, superhydrophilic and slippery surface. The first part will focus on the influence of extreme wettability to cell adhesion behaviors. The second part will concentrate on the adhesion behaviors of biomacromolecule on superwettable surfaces including proteins and nucleic acids. Finally, the influences of wettability to small molecules adhesion behaviors on material surfaces also have been investigated. The mechanism of superwettable surfaces and their influences on biomolecules adhesion behaviors have been studied and highlighted.

    更新日期:2020-01-09
  • Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites†
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-02
    Nicolas Debons; Dounia Dems; Christophe Hélary; Sylvain Le Grill; Lise Picaut; Flore Renaud; Nicolas Delsuc; Marie-Claire Schanne-Klein; Thibaud Coradin; Carole Aimé
    更新日期:2020-01-09
  • Thermogelling chitosan-based polymers for the treatment of oral mucosa ulcers†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-26
    Zheng Luo; Kun Xue; Xikui Zhang; Jason Y. C. Lim; Xiyu Lai; David James Young; Zhong-Xing Zhang; Yun-Long Wu; Xian Jun Loh
    更新日期:2020-01-09
  • Nanoparticles’ Size and Chemical Modification have Detrimental Role on the Interaction of Nano Gold with Brain: Extent of Accumulation and Toxicity
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-08
    Nouf Mahmoud; Abdulrahim Al-Basha; Suhair Hikmat; Lama Hamadneh; Rand Zaza; Ziad Shriydeh; Enam Khalil

    Blood brain barrier (BBB) is a very selective barrier that protects the brain and the central nervous system (CNS) from the entry of harmful substances and helps regulate the exchange of different molecules and nutrients from and into the brain and the CNS. This selectivity makes delivering therapeutic and diagnostic materials across the BBB very challenging. In this study, different shapes and sizes of gold nanoparticles (GNP) were synthesized and functionalized with five different thiolated ligands to acquire GNP with various surface chemistries. The potential of GNP of different properties to be accumulated into the brain through BBB and into other organs was investigated in mouse model using qualitative and quantitative approaches. Gold nanorods (GNR) functionalized with 4-mercaptophenol (Mph) showed the highest penetration ability across the BBB into the brain with no significant deposition into other organs. Interestingly, increasing the size of GNR retarded their delivery into the brain, while enhanced their accumulation into other organs. On the other hand, gold nanospheres (GNS) demonstrated high deposition percentages into the brain and other organs with possible toxic effect. The properties of GNP have a crucial role in their interaction with BBB and accumulation into the brain and other organs. GNP could be considered as a promising nano-platform for drug delivery into the brain and as a photothermal-induced agent against brain cancer.

    更新日期:2020-01-09
  • Biomimetic tissue models reveal the role of hyaluronan in melanoma proliferation and invasion
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-08
    Jiranuwat Sapudom; Khiet-Tam Nguyen; Steve Martin; Tom Wippold; Stephanie Möller; Matthias Schnabelrauch; Ulf Anderegg; Tilo Pompe

    Interactions of hyaluronan (HA) and tumor and stromal cells are highly discussed as one of the major contributors in tumor progression and metastasis. The balance of HA in the tissue is highly regulated by two key enzyme classes; hyaluronan synthases (HAS) and hyaluronidases (HYAL). Current reports hint that HA amount in the tissue is correlated with poor prognosis in melanoma, the most life-threatening skin tumor. In this work, we generated in vivo mouse models with low and high expression of Has2 and used the models for studying melanoma proliferation of B78D14 melanoma cell line. We found that a strong reduction of HA amount in the skin decreased tissue stiffness and melanoma cell proliferation at the tumor boundary. Since tumor cells have a direct contact to the HA in the tumor and at the stroma interface, we reconstituted different biomimetic in vitro models, namely, (i) decellularized fibroblast matrix (FbECM), (ii) fibroblast embedded into 3D collagen matrices (FbColl), and (iii) well-defined HA-functionalized 3D collagen matrices (HAColl), to recapitulate melanoma cell behavior at the tumor boundary. We found no considerable effect of high and low amounts of fibroblast-derived HA in the matrices on melanoma proliferation and invasion. However, HYAL1-treated FbECM and FbColl, and HAColl functionalized with low-molecular weight HA (LMW-HA, 34 kDa) promoted proliferation and invasion of melanoma cells in a concentration dependent manner. Our results emphasize the molecular weight specific effects of HA in regulation of melanoma behavior and provide an alternative explanation of the in vivo observation.

    更新日期:2020-01-08
  • Melanin-like Nanoparticles Loaded with Angiotensin Antagonist for Improved Photothermal Cancer Therapy
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-08
    Zhengjie Zhou; Yang Yan; Qiang Zhang; Yiyun Cheng

    The abnormal tumor growth induces solid stress in tumors, thus reducing blood perfusion. As a result, the impaired blood perfusion plus with dense interstitial matrix in tumors significantly reduce the penetration and efficacy of nanotherapeutics. In this study, we developed a losartan-loaded polydopamine nanoparticle (PLST) for enhanced delivery of nanoparticles to tumors and improved photothermal cancer therapy. Losartan, an angiotensin inhibitor, is also able to alleviate the solid stress in tumors. It was laden on polydopamine nanoparticle via π-π stacking and was released upon tumor extracellular acidity. PLST reduced collagen production in vitro along with lowered expression of profibrotic factors of TGF-β1, CCN2, and TIMP-1. The in vivo studies revealed that PLST reduced solid stress in tumors, and the amount of PLST accumulated in tumors was enhanced. The efficiency of photothermal ablation of tumors was significantly enhanced by using PLST.

    更新日期:2020-01-08
  • Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-26
    Federica Sodano; Robert J. Cavanagh; Amanda K. Pearce; Loretta Lazzarato; Barbara Rolando; Aurore Fraix; Thais F. Abelha; Catherine E. Vasey; Cameron Alexander; Vincenzo Taresco; Salvatore Sortino
    更新日期:2020-01-08
  • A self-assembled DNA tetrahedron as a carrier for in vivo liver-specific delivery of siRNA†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-16
    Kyoung-Ran Kim; Hyun Jegal; Junghyun Kim; Dae-Ro Ahn
    更新日期:2020-01-08
  • Melatonin/polydopamine nanostructures for collective neuroprotection-based Parkinson's disease therapy†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-11
    Anup K. Srivastava; Subhasree Roy Choudhury; Surajit Karmakar
    更新日期:2020-01-08
  • A Facile and Universal Strategy to Endow Implant Materials Antibacterial Ability via Alkalinity Disturbing Bacterial Respiration
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-07
    Ji Tan; Zixiao Liu; Donghui Wang; Xianming Zhang; Shi Qian; Xuanyong Liu

    Multifarious strategies have been proposed to enhance the antibacterial ability of implants surfaces for preventing bacterial infection, however, developing facile and universal modification methods still remains extremely elusive. Herein, inspired by that the electron transfer respiratory chain of bacteria is embedded in the membrane, we proposed a novel strategy of local alkalinity disturbing bacterial respiration to endow implant materials with antibacterial ability. As a demonstration, MgO was deposited on biomedical titanium via magnetron sputtering to regulate surface alkalinity. With the thickness of MgO films increasing, it exhibited excellent antibacterial rate against both Gram-negative and positive bacteria. The antibacterial mechanism was confirmed that alkaline surface can disturb the bacterial respiration action via weakening the transmembrane proton concentration gradient, resulting in the block of energy metabolism and the increase of oxidative stress of bacteria. Cell experiments indicated that MgO films not only have no obvious cytotoxicity to osteoblast cells but also can selectively kill bacteria and promote cell proliferation in the presence of both bacteria and cells. More importantly, the by-product of MgO was only the biocompatible Mg2+, reducing any concerns about potential toxic effects. Furthermore, sputtering alkaline MgO film was confirmed to work well on polyetheretherketone polymer and zirconia ceramic implants, which indicates this strategy has broad prospects of clinic application for preventing implant-associated bacterial infection.

    更新日期:2020-01-07
  • Chain Conformation Transition Induced Host-guest Assembly between Triple Helical Curdlan and β-CD for Drug Delivery
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-06
    Qingye Liu; Du Yang; Tongyi Shang; Lixiao Guo; Bin Yang; Xiaojuan Xu

    The unique conformation transition from triple helix to single coils for the triple helical β-D-glucans has pave the way to fabricate various functional nanocomposites through the denature-renature process. This study firstly reports a novel kind of naturally-derived supramolecular polymer micelles consisting of the single-stranded chains of Curdlan (CUR) and β-CDs. It is proposed that β-CDs as the host molecules were threaded onto the single β-glucan chains (denatured triplex CUR) via the host-guest interaction, thereby the formation of supramolecular micelles. The results from the 1H NMR, FT-IR, XRD and 2D 1H NOESY NMR confirmed the formation of inclusion complex and the existence of core-shell structure of the supramolecular assembly. TEM images and DLS revealed that the self-organized micelles displayed the regular spherical shape with an average diameter of ~27 nm. Furthermore, the hydrophobic anticancer drug camptothecin (CPT) was selected as a model drug and successfully encapsulated into the CUR/β-CD micelles. The drug-loaded micelles exhibited a steady sustained-release pattern regardless of the environmental pH. The flow cytometry and confocal laser scanning microscopy measurements confirmed that the CPT-loaded micelles could be well internalized into HepG 2 cells and continuously release the drug molecules inside the tumor cells. Furthermore, the in vivo experiments demonstrated that CPT-loaded micelles could effectively inhibit tumor growth by comparison to free drugs. This concept will give a favorable platform to construct intelligent drug delivery systems for potential use.

    更新日期:2020-01-06
  • Optimized fluorodendrimer-incorporated hybrid lipid-polymer nanoparticle for efficient siRNA delivery
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-06
    Qingqing Xiong; Yujing Li; Kun Zhou; Ping Chen; Hua Guo; Lu Chen; Jianxun Ding; Tianqiang Song; Jinjun Shi

    Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silence of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.

    更新日期:2020-01-06
  • Opposite responses of normal hepatocytes and hepatocellular carcinoma cells to substrate viscoelasticity†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-16
    Kalpana Mandal; Ze Gong; Alexis Rylander; Vivek B. Shenoy; Paul A. Janmey
    更新日期:2020-01-06
  • Identification of a prolonged acting molecule GLP-1R agonist for the treatment of femoral defect
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-03
    Ning Wang; Xuanchen Liu; Lei Shi; yanwu liu; shuo guo; wenwen liu; jingru meng; xue ma; Xiaokang Li; Zheng Guo

    Autografts are still regarded as the gold standard treatment for bone defects but they require additional surgery that causes pain for the patient. Thus, alternatives that can substitute for grafts are required. In the present study, a novel poly-GLP-1 molecule was developed using a polymeric pro-drug strategy which was found to accelerate bone healing in a mouse femoral defect model. Furthermore, the poly-GLP-1 molecule induced osteogenesis and inhibited adipogenesis in bone marrow-derived mesenchymal stem cells (BMSCs). The results demonstrate that poly-GLP-1 promoted M2 polarization of bone marrow-derived macrophages (BMDMs) and increased the levels of TGF-β1 in the bone marrow, resulting in the migration of an increased number of CD29+Sca-1+ BMSCs to the bone surface. Finally, we found that poly-GLP-1 facilitated the migration of BMSCs due to transduction of the Smad2 signaling pathway, causing increased numbers of CD31+Endomucin+ endothelial cells in bone marrow that promoted bone formation. These results support poly-GLP-1 as a potential bone-healing agent and suggest it may have a promising role in the clinical treatment of fracture-repair.

    更新日期:2020-01-04
  • A dual-functional implant with enzyme-responsive effect for bacterial infection therapy and tissue regeneration
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-03
    Yao Ding; Yansha Hao; Yuan Zhang; Bailong Tao; Maowen Chen; Chuanchuan Lin; Peng Liu; Kaiyong Cai

    Biomaterials-associated bacterial infection is one of the major causes of implant failure. The treatment of such an implant infection typically requires the elimination of bacteria and accelerating tissue regeneration around implants simultaneously. To address this issue, an ideal implanted material should have the dual functions of bacterial infection therapy and tissue regeneration at the same time. Herein, an enzyme-responsive nanoplatform was fabricated in order to treat implant-associated bacterial infection and accelerate tissue regeneration in vivo. Firstly, Ag nanoparticles were pre-encapsulated in mesoporous silica nanoparticles (MSN) by one-pot method. Then, poly-L-glutamic acid (PG) and polyallylamine hydrochloride (PAH) was layer-by-layer (LBL) assembly on MSN-Ag to form LBL@MSN-Ag nanoparticles. Furthermore, LBL@MSN-Ag nanoparticles were deposited on the surface of polydopamine-modified Ti substrates. PG is a homogenous polyamide composed of an amide linkage, which can be degraded by glutamyl endonuclease secreted by Staphylococcus aureus. The inductively coupled plasma spectroscopy (ICP) results proved that the LBL@MSN-Ag particles have a significant enzyme responsive release of Ag ions. Furthermore, results of antibacterial experiments in vitro showed that the Ti substrates modified with LBL@MSN-Ag nanocoating presented excellent antibacterial effect. As for animal experiment in vivo, in a bacterial infected femur-defect rat model, the modified Ti implants effectively treated bacterial infection. More importantly, the results of Micro-CT, haematoxylin-eosin and Masson’s trichrome staining demonstrated that the modified Ti implants significantly promoted the formation of new bone tissue after implantation for 4 weeks. The present system paves the way for developing the next generation of implant with the functions of treating bacterial infection and promoting tissue regeneration.

    更新日期:2020-01-04
  • Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-03
    Kalirajan Cheirmadurai; Thanikaivelan Palanisamy

    The existence of diabetes and microbial infection in burn wounds makes the healing process more complex. Herein, we synthesize a collagen based hybrid scaffold incorporated with silica-resorcinol composite and cross-linked with oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection. The spectroscopic analyses of the hybrid scaffolds reveal the chemical and structural integrity of the collagen. The hybrid scaffolds are shown to be appropriate for in-vivo tissue regeneration through cytocompatibility and hemocompatibility studies. Scaffolds were applied to diabetic albino rats induced with chronically infected burn wounds with respective controls. Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups show improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing. The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.

    更新日期:2020-01-04
  • Growing a Backbone – Functional Biomaterials and Structures for Intervertebral Disc (IVD) Repair and Regeneration: Challenges, Innovations, and Future Directions
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-03
    Matthew David Harmon; Daisy M Ramos; Nithyadevi Duraisamy; Rosalie Bordett; Swetha Rudraiah; Syam Nukavarapu; Isaac Moss; Sangamesh Kumbar

    Back pain and associated maladies can account for an immense amount of healthcare cost and loss of productivity in the workplace. Particularly, spine related injuries in the US affects upwards of 5.7 million people each year. The degenerative disc disease treatment almost always arises due to a clinical presentation of pain and/or discomfort. Preferred conservative treatment modalities include the use of non-steroidal anti-inflammatory medications, physical therapy, massage, acupuncture, chiropractic work, and dietary supplements like glucosamine and chondroitin. Artificial disc replacement, also known as total disc replacement is a treatment alternative to spinal fusion. The goal of artificial disc prostheses is to replicate the normal biomechanics of the spine segment, thereby preventing further damage to neighboring sections. Artificial functional disc replacement through permanent metal and polymer-based components continue to evolve, but is far from recapitulating native disc structure and function, and suffers from the threat of unsuccessful tissue integration and device failure. Tissue engineering and regenerative medicine strategies combines novel material structures, bioactive factors and stem cells alone or in combination to repair and regenerate IVD. These efforts are at very early stages and a more in depth understanding of IVD metabolism and cellular environment will also bring a clearer understanding of the native environment for which the tissue engineering scaffold should mimic. The current review focusses on the strategies for a successful regenerative scaffold for IVD regeneration and the need for defining new materials, environments, and factors that are so finely tuned in the healthy human intervertebral disc in hopes of treating such a prevalent degenerative process.

    更新日期:2020-01-04
  • Angiopep-2 conjugated nanoparticles loaded with doxorubicin for the treatment of primary central nervous system lymphoma
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-11
    Xiao-Xiao Shi; Wei-Min Miao; Di-Wen Pang; Jia-Si Wu; Qi-Song Tong; Jia-Xian Li; Jia-Qi Luo; Wen-Yu Li; Jin-Zhi Du; Jun Wang
    更新日期:2020-01-04
  • Fabrication of strong hydrogen-bonding induced coacervate adhesive hydrogels with antibacterial and hemostatic activities
    Biomater. Sci. (IF 5.251) Pub Date : 2020-01-02
    Dongfei Zhang; Ziyang Xu; Haofei Li; Chuanchuan Fan; Chunyan Cui; Tengling Wu; Meng Xiao; Yang Yang; Jinahai Yang; Wenguang Liu

    In this work, a biocompatible poly(N-hydroxyethyl acrylamide) (PHEAA) with hydrogen bonding acceptors and donors in side chains is prepared and mixed with tannic acid (TA) to form a supramolecular coacervate hydrogel (TAHE) due to the multiple hydrogen-bonding interactions between TA and PHEAA. The coacervate TAHE hydrogel exhibits not only a self-healing and antibacterial property, but also strong adhesion to various substrates, with an average adhesion strength of 722 kPa, 522 kPa, 484 kPa, and 322 kPa to the substrate of iron, PMMA, ceramics, and glass, respectively. Notably, the hydrogel reformed from the rehydration of freeze-dried and ground TAHE hydrogel powder remains the initial adhesive performance and exhibits an excellent hemostatic ability. This novel adhesive hydrogel holds great potential as an adhesive hemostatic material for self-rescue in emergency situations.

    更新日期:2020-01-02
  • Self-adaptive antibacterial surfaces with bacterium-triggered antifouling-bactericidal switching properties†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-19
    Yidan Zhang; Xiang Zhang; Yu-Qing Zhao; Xin-Yang Zhang; Xiaokang Ding; Xuejia Ding; Bingran Yu; Shun Duan; Fu-Jian Xu
    更新日期:2020-01-02
  • Single-step formulation of levodopa-based nanotheranostics – Strategy for ultra-sensitive high longitudinal relaxivity MRI guided switchable therapeutics
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-31
    Dan Tian; Hongxia Xu; Bing Xiao; Xiaoxuan Zhou; Xiangrui Liu; Zhuxian Zhou; Hirak Kumar Patra; Nigel K. H. Slater; Jianbin Tang; Youqing Shen

    Nanotheranostics (combined diagnosis and therapy) is emerging as the integral part of future therapeutic strategy. However, developing and fabrication of nanotheranostic module involves multistep processes and always faces formulation challenges. The complexity involved during its multi-step formulations hinders them from reproducible industrial production and clinical translation. Therefore, a facile synthesis for multifunctional nanotheranostics is critical to its translational success. In this present report, we have developed a one-pot facile strategy to prepare MRI-visible photothermal theranostic switchable module (T-SWITCH). These nanoparticles are synthesized through polymerization of levodopa together with the reduction of KMnO4 in presence of silk sericin for the formation of manganese dioxide particles within T-SWITCH. The synthesized T-SWITCH showed uniform size distribution around 100 nm with high longitudinal relaxivity coefficient (r1) up to 61.94 mM-1s-1. The reported r1 of T-SWITCH is exceedingly higher than any previously reported manganese-based contrast agents with first-rate in vitro and in vivo contrast enhancement capability. T-SWITCH can be activated to switch its therapeutic mode by near-infrared light (NIR). It exhibited strong excitable absorption in the safer and biological NIR window between 650~900nm. We have validated the significant efficacy of T-SWITCH anti-cancer therapeutic efficacy both in vitro and in vivo through switchable photothermal therapy.

    更新日期:2019-12-31
  • “OFF/ON” Fluorescence Imaging Guided Cancer Diagnosis and Multi-Modal Therapy
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-26
    Changrong Wang; Yanliang Dong; Xiaoguang Shi; Jinxuan Guo; Jianhua Zhang; Liandong Deng; Zhiqiang Lin; Pingsheng Huang; Yongli Shi; Weiwei Wang; Anjie Dong

    An efficient theranostic nanoplatform responding tumour microenvironment with characters of simple and flexible combination owns great potentials in cancer diagnosis and therapy. To design a nanoplatform that facilitates tumour imaging and chemo-photothermal multi-modal treatment, a triblock copolymer mPEG5k-b-PDPA-b-P(nBMA-r-Cystamine3) (abbreviated EPB-3) was synthesized through RAFT polymerization. Fluorescent molecular indocyanine green (ICG-OSU) could be easily conjugated with the EPB-3 copolymer through disulfide bonds, but detached in the tumour cells by responding the high expression of reductant glutathione. EPB-3 owed the optimal structure, which afforded its self-assembly nanoparticles (NPs) significant characters, including (1) ideal reduction-sensitive OFF/ON fluorescence signal transition function with conjugated with one ICG (EPB-3-ICG1) in vitro and in vivo; (2) excellent loading capacities both for hydrophobic chemotherapeutics and photothermal agents, providing flexible combination characters for tumour multi-modal diagnosis and treatments; (3) long period of intracellular pH-sensitive sustain drug release with stable particle size and (4) good biocompatibility. In our results, the most sensitive and strongest OFF/ON amplified fluorescence signal (ΔON/OFF value 27.0) obtained by EPB-3-ICG1 NPs. EPB-3-ICG1 NPs also could initiate intensive fluorescence signals in different tumour tissue with a very low dose (0.098 mg/kg ICG). The EPB-3 and EPB-3-ICG1 could efficiently entrap Au nanorods to form EPB-3-ICG1@Au NPs. The obtained EPB-3-ICG1@Au NPs could synchronously induce strong tumour fluorescence imaging and high local photothermal effect synchronously, indicating potential in imagine-guided photothermal therapy. Furthermore, by physically co-entrapping paclitaxel (PTX) and ICG, we prepared EPB-3@PTX@ICG NPs and observed highly enhancement chemo-photothermal in apoptosis of 4T1 cells in vitro. Excitingly, a single intravenous injection of EPB-3@PTX@ICG NPs followed by once local near-infrared light (NIR, 808 nm) treatment for 10 min could lead to significantly inhibiting tumour growth, avoiding tumour metastasis and extending survival of mice. All the above results suggest that the EPB-3 provide a nanoplatform with the characters of simple structure, convenience of use and flexible combination, holding potentials for multi-modal diagnose and therapy.

    更新日期:2019-12-27
  • A thin hydrogel barrier linked onto cell surface sialic acids through covalent bonds induces cancer cell death in vivo†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-16
    Kimika Ono; Yuka Sanada; Yuka Kimura; Seika Aoyama; Natsumi Ueda; Tokitaka Katayama; Koji Nagahama
    更新日期:2019-12-25
  • Urinary bladder matrix scaffolds improve endometrial regeneration in a rat model of intrauterine adhesions
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-23
    Honghong Zhang; Qing Zhang; Jian Zhang; Fei Sheng; Shuang Wu; Fu Yang; Wen Li
    更新日期:2019-12-23
  • PD-L1-targeted nanobubbles loaded with docetaxel produce a synergistic effect for the treatment of lung cancer under ultrasound irradiation
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-23
    Jinhe Guo; Tiankuan Li; Zhongqian Hu; Chao Wang; Jian Yang; Chuhui Zeng; Rui Fan

    Immunotherapy is gradually beginning to be as important as traditional therapy in the treatment of cancer, but adverse drug reactions limit patient benefits from PD1/PD-L1 checkpoint inhibitor drugs in the treatment of non-small cell lung cancer (NSCLC). As a chemotherapeutic drug for NSCLC, docetaxel (DTX) can synergize with PD1/PD-L1 checkpoint inhibitors but increase haematoxicity and neurotoxicity. Herein, anti-PD-L1 monoclonal antibody (mAb)-conjugated and docetaxel-loaded multifunctional lipid-shelled nanobubbles (PDNs), which were designed with biological safe phospholipid to produce synergistic antitumour effects, reduced the incidence of side effects and promoted therapeutic effects under ultrasound (US) irradiation. The PDNs were prepared by the acoustic-vibration method and then conjugated with an anti-PD-L1 mAb. We studied the material features of the nanobubbles, their cytotoxic effects, cellular apoptosis and cell cycle inhibition. A xenograft tumour model was established to test the drug concentration-dependent and antitumour effects of the PDNs combined with US irradiation, and an orthotopic lung tumour model simultaneously verified the antitumour effect of this synergistic treatment. The PDNs achieved higher cellular uptake than free DTX, especially when combined with US irradiation. The PDNs combined with US irradiation also induced an increased rate of cellular apoptosis and an elevated G2-M arrest rate in cancer cells, which was positively correlated with PD-L1 expression. An in vivo study showed that synergistic treatment had relatively strong effects of tumour growth inhibition, increased survival time and decreased adverse effect rates. Our study possibly provides a well-controlled design for immunotherapy and chemotherapy and has promising potential as a clinical application for NSCLC treatment.

    更新日期:2019-12-23
  • Improved osseointegration with rhBMP-2 intraoperatively loaded in a specifically designed 3D-printed porous Ti6Al4V vertebral implant
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-16
    Teng Zhang; Qingguang Wei; Daoyang Fan; Xiaoguang Liu; Weishi Li; Chunli Song; Yun Tian; Hong Cai; Yufeng Zheng; Zhongjun Liu
    更新日期:2019-12-23
  • Enzymatically crosslinked gelatin–laminin hydrogels for applications in neuromuscular tissue engineering†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-06
    Rachel R. Besser; Annie C. Bowles; Ahmad Alassaf; Daniel Carbonero; Isabella Claure; Ellery Jones; Joseph Reda; Laura Wubker; Wyndham Batchelor; Noël Ziebarth; Risset Silvera; Aisha Khan; Renata Maciel; Mario Saporta; Ashutosh Agarwal
    更新日期:2019-12-21
  • Construction of small-sized superparamagnetic Janus nanoparticles and their application in cancer combined chemotherapy and magnetic hyperthermia
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-19
    Liqin Xie; Wanwan Jin; Xirui Zuo; Shenglu Ji; Wenbin Nan; Hongli Chen; Songtai Gao; Qiqing Zhang

    A novel Janus nanoparticles (J-NPs) is developed by using single iron oxide (Fe3O4) nanoparticle as the core and hydrophobic/hydrophilic polymeric brushes as the cloak. Because of the superparamagnetism and asymmetrical functionality of J-NPs, it is used as drug carrier and therapeutic agent for cancer chemotherapy and magnetic hyperthermia with a magnetic resonance imaging (MRI) guide. The asymmetrical functionality are constituted of hydrophobic polymethyl methacrylate (PMMA) brushes and hydrophilic polyacrylic acid (PAA) brushes, which are ‘grafting to’ or ‘grafting from’ Fe3O4 nanoparticles via activators regenerated by electron transfer atom transfer radical polymerization. The terminal chains of PMMA and PAA brushes are coordinated with Fe3O4 nanoparticle, so PMMA/Fe3O4/PAA J-NPs possess structural stability in solvent. Because of the brush-structure, PMMA/Fe3O4/PAA J-NPs show high encapsulation efficiency (89.75 ± 2.35%) and loading capacity (8.95 ± 0.26%). Under the alternating magnetic field (AMF), drug-loaded J-NPs achieve the highest cell proliferation-inhibition ratio in cell proliferation test in vitro and tumor growth inhibition test in vivo compare to single chemotherapy or magnetic hyperthermia. Meanwhile, J-NPs show good T2 imaging.

    更新日期:2019-12-19
  • A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-18
    Xumei Ouyang; Xiaoling Wang; Heinz-Bernhard Kraatz; Soha Ahmadi; Jianqing Gao; Yuanyuan Lv; Xiaoyi Sun; Yongzhuo Huang
    更新日期:2019-12-19
  • Ultrasmall theranostic nanozymes to modulate tumor hypoxia for augmenting photodynamic therapy and radiotherapy†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-11
    Qing Dan; Dehong Hu; Yongshuai Ge; Shiyu Zhang; Sanqing Li; Duyang Gao; Wanxian Luo; Teng Ma; Xin Liu; Hairong Zheng; Yingjia Li; Zonghai Sheng
    更新日期:2019-12-19
  • Tough hydrogel module towards an implantable remote and controlled release device†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-11
    Zhi Wei Kenny Low; Yifei Luo; Kangyi Zhang; Qianyu Lin; Cally Owh; Xiaodong Chen; Xian Jun Loh
    更新日期:2019-12-18
  • 29th annual conference of the European Society for Biomaterials
    Biomater. Sci. (IF 5.251) Pub Date : 2019-12-06
    Pamela Habibovic; Sandra Hofmann; Jeroen van den Beucken
    更新日期:2019-12-18
  • 3D biofabrication of microfiber-laden minispheroids: a facile 3D cell co-culturing system†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-25
    Mingjun Xie; Qing Gao; Jingjiang Qiu; Jianzhong Fu; Zichen Chen; Yong He
    更新日期:2019-12-18
  • Correction: Silk based scaffolds with immunomodulatory capacity: anti-inflammatory effects of nicotinic acid
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-22
    Abdollah Zakeri Siavashani; Javad Mohammadi; Katharina Maniura-Weber; Berna Senturk; Jhamak Nourmohammadi; Behnam Sadeghi; Lukas Huber; Markus Rottmar

    Correction for ‘Silk based scaffolds with immunomodulatory capacity: anti-inflammatory effects of nicotinic acid’ by Abdollah Zakeri Siavashani et al., Biomater. Sci., 2019, DOI: 10.1039/c9bm00814d.

    更新日期:2019-12-18
  • Red phosphorus decorated graphene oxide nanosheets: label-free DNA detection†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-22
    Tapas Kumar Mandal; Yong Rok Lee; Nargish Parvin
    更新日期:2019-12-18
  • Collaborative assembly of doxorubicin and galactosyl diblock glycopolymers for targeted drug delivery of hepatocellular carcinoma†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-18
    Jianghua Li; Yang Zhang; Chao Cai; Xiaozhi Rong; Meng Shao; Jiarui Li; Chendong Yang; Guangli Yu
    更新日期:2019-12-18
  • A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-14
    Tian Zhang; Yajun Wang; Xianbin Ma; Cuilan Hou; Shuangyu Lv; Die Jia; Yi Lu; Peng Xue; Yuejun Kang; Zhigang Xu
    更新日期:2019-12-18
  • Canalicular domain structure and function in matrix-free hepatic spheroids†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-13
    Vikas Raj Sharma; Ananya Shrivastava; Benoit Gallet; Elizaveta Karepina; Peggy Charbonnier; Mireille Chevallet; Pierre-Henri Jouneau; Aurélien Deniaud
    更新日期:2019-12-18
  • A two-pronged anti-leukemic agent based on a hyaluronic acid–green tea catechin conjugate for inducing targeted cell death and terminal differentiation†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-13
    Kun Liang; Ki Hyun Bae; Akiko Nambu; Bibek Dutta; Joo Eun Chung; Motomi Osato; Motoichi Kurisawa
    更新日期:2019-12-18
  • AIE/FRET-based versatile PEG-Pep-TPE/DOX nanoparticles for cancer therapy and real-time drug release monitoring†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-12
    Tian-Tian Wang; Qi-Chun Wei; Zhen-Tao Zhang; Meng-Ting Lin; Jie-Jian Chen; Yi Zhou; Ning-Ning Guo; Xin-Cheng Zhong; Wen-Hong Xu; Zhan-Xiang Liu; Min Han; Jian-Qing Gao
    更新日期:2019-12-18
  • 更新日期:2019-12-18
  • Leukocyte-mimicking nanovesicles for effective doxorubicin delivery to treat breast cancer and melanoma†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-07
    Roberto Molinaro; Jonathan O. Martinez; Assaf Zinger; Alessandro De Vita; Gianluca Storci; Noemi Arrighetti; Enrica De Rosa; Kelly A. Hartman; Nupur Basu; Nima Taghipour; Claudia Corbo; Ennio Tasciotti
    更新日期:2019-12-18
  • Scleral ossicles: angiogenic scaffolds, a novel biomaterial for regenerative medicine applications†
    Biomater. Sci. (IF 5.251) Pub Date : 2019-11-06
    Marta Checchi; Jessika Bertacchini; Francesco Cavani; Maria Sara Magarò; Luca Reggiani Bonetti; Geltrude Rita Pugliese; Roberto Tamma; Domenico Ribatti; Delphine B. Maurel; Carla Palumbo
    更新日期:2019-12-18
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