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A hemodynamic model of artery bypass graft considering microcirculation function Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2024-03-05 Fan He, Minru Li, Lu Hua, Tingting Guo
BACKGROUND:The incidence of arterial stenosis is increasing year by year. In order to better diagnose and treat arterial stenosis, numerical simulation technology has become a popular method. OBJECTIVE:A novel model is constructed to investigate the influence of microcirculation on the hemodynamicsof artery bypass graft. METHODS:In this paper, a severely narrow artery bypass graft model is considered
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Effect of gold-conjugated resveratrol nanoparticles on glioma cells and its underlying mechanism Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2024-02-22 Xiaojiang Liu, Zongfeng Guo, Jun Li, Demo Wu, Zhongping Liu, Cheng Guan, Yixiang Guan, Xiaomin Lu
BACKGROUND: Glioblastoma is the most aggressive brain tumor with poor prognosis. Although Resveratrol (Rsv) is known to have therapeutic effects on glioma, the effects of gold-conjugated resveratrol nanoparticles (Rsv-AuNPs) on glioma cells are rarely reported. OBJECTIVE:We aimed to investigate theeffects of Rsv-AuNPs on glioma cells and its underlying mechanism. METHOD:Human glioma cell line U87 was
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Wear performance of Ti-based alloy coatings on 316L SS fabricated with the sputtering method: Relevance to biomedical implants Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2024-02-21 Shunmuga Priyan Murugan, Godwin George, Julyes Jaisingh
BACKGROUND:This investigation was conducted to encapsulate 316L SS with a Ti-based alloy coating. OBJECTIVE:The aim was to fabricate a coating using TiN, TiO2, and TiCoCr powders on 316L SS through the physical vapor deposition (PVD) sputtering process. METHODS:The powders were consecutively coatedon 316L SS through the PVD sputtering process with coating durations of 30, 60, and 90 min. Further microhardness
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Simvastatin-loaded 3D aerogel scaffolds promote bone regeneration Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2024-02-12 Lai Linfeng, Zhou Xiaowei, Chen Xueqin, Zhu Xianfeng
Abstract BACKGROUND: It is imperative to design a suitable material for bone regeneration that emulates the microstructure and compositional framework of natural bone while mitigating the shortcomings of current repair materials. OBJECTIVE: The aim of the study is to synthesize a 3D aerogel scaffold composed of PLCL/gelatin electro-spun nanofiber loaded with Simvastatin and investigate its biocompatibility
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Biomimetic grafts from ultrafine fibers for collagenous tissues Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2024-02-09 Fariza Mukasheva, Ainur Zhanbassynova, Cevat Erisken
BACKGROUND:The ligament is the soft tissue that connects bone to bone and, in case of severe injury or rupture, it cannot heal itself mainly because of its poor vascularity and dynamic nature. Tissue engineering carries the potential to restore the injured tissue functions by utilization of scaffolds mimicking the structure of native ligament. Collagen fibrils in the anterior cruciate ligament (ACL)
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Lipid index to quantify the absorbed lipids in retrieved UHMWPE components of joint arthroplasty Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2024-01-24 Hideyuki Sakoda, Yusuke Tsuboko, Yoshihiro Okamoto, Eiichi Yamamoto, Takashi Imagama, Takashi Sakai, Hidetoshi Hamada, Nobuhiko Sugano
BACKGROUND:The ultra-high molecular weight polyethylene (UHMWPE) component of artificial joints is one of the most important factors affecting the clinical outcomes of joint arthroplasty. Although the possibility of in vivo UHMWPE degradation caused by absorbed lipids has been reported, a quantitative evaluation of this phenomenon has not yet been performed. OBJECTIVE:This study aimed to establish
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Polyvinylpyrrolidone hydrogel coating for ureteral stent: Safety and performance evaluation Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2024-01-23 Haibin Tang, Dimeng Wu, Zheng Liu, Xi Liu, Heng Yuan, Xiaosong Jin, Shuai Gao, Gang Chen
BACKGROUND:Ureteral stents are commonly used in urology. However, complications such as encrustation and infection on the surface of the stent, and injury to the ureteral mucosa can occur after implantation, causing discomfort for patients. OBJECTIVE:We intend to confirm the biosafety of polyvinylpyrrolidone (PVP) hydrophilic coating and its lubrication properties for surface modification of ureteral
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Customized design and biomechanical property analysis of 3D-printed tantalum intervertebral cages Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2024-01-10 Yutao Zhang, Shu Du, Wurikaixi Aiyiti, Yong Teng, Ru Jia, Houfeng Jiang
BACKGROUND:Intervertebral cages used in clinical applications were often general products with standard specifications, which were challenging to match with the cervical vertebra and prone to cause stress shielding and subsidence. OBJECTIVE:To design and fabricate customized tantalum (Ta) intervertebral fusion cages that meets the biomechanical requirements of the cervical segment. METHODS:The lattice
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Antibacterial effect of Ag-containing hydroxyapatite thin film fabricated by sputtering Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2024-01-04 K. Ozeki, Y. Nakajima
BACKGROUND:Infections related to joint prosthesis are still a major concern for orthopedic surgeons. Hydroxyapatite (HA) is a useful biocompatible material because of its good osteocompatibility. Antibacterial HA coatings have been fabricated with addition of antibacterial agents such as Ag to HA using the plasma spraying method. However, the plasma-sprayed HA coating suffers from fractures at large
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Dual therapy of cancer using optimal control supported by swarm intelligence Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-12-28 Poh Ling Tan, Jeevan Kanesan, Joon Huang Chuah, Irfan Anjum Badruddin, Abdallah Abdellatif, Sarfaraz Kamangar, Mohamed Hussien, Maughal Ahmed Ali Baig, N. Ameer Ahammad
BACKGROUND:The scientific revolution in the treatment of many illnesses has been significantly aided by stem cells. This paper presents an optimal control on a mathematical model of chemotherapy and stem cell therapy for cancer treatment. OBJECTIVE:To develop effective hybrid techniques that combine the optimal control theory (OCT) with the evolutionary algorithm and multi-objective swarm algorithm
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Optimizing chemotherapy treatment outcomes using metaheuristic optimization algorithms: A case study Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-12-21 Prakas Gopal Samy, Jeevan Kanesan, Irfan Anjum Badruddin, Sarfaraz Kamangar, N. Ameer Ahammad
BACKGROUND:This study explores the dynamics of a mathematical model, utilizing ordinary differential equations (ODE), to depict the interplay between cancer cells and effector cells under chemotherapy. The stability of the equilibrium points in the model is analysed using the Jacobian matrix and eigenvalues. Additionally, bifurcation analysis is conducted to determine the optimal values for the control
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Study of the mechanism of action of sand therapy on atherosclerosis based on the two-phase flow-Casson model Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-11-30 Fu Rongchang, Wang Kun, Wu Hui
BACKGROUND:Sand therapy is a non-pharmacological physiotherapy method that uses the natural environment and resources of Xinjiang to treat through the heat transfer and magnetic effects of sand. OBJECTIVE:Employing the two-phase flow-Casson blood flow model, we investigate the mechanism of atherosclerosis prevention via sand therapy, offering a biomechanical theoretical rationale for the prevention
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Varus/valgus stability in imageless robotic-assisted total knee arthroplasty applying three-dimensional assessment of varus/valgus stress X-rays Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-11-29 Hiroki Hijikata, Tomoharu Mochizuki, Keisuku Maeda, Osamu Tanifuji, Go Omori, Noriaki Yamamoto, Hiroyuki Kawashima
BACKGROUND:The postoperative varus/valgus stability assessment in stress X-rays has been established as an evaluation index. However, it is performed by the two-dimensional (2D) method rather than the three-dimensional (3D) method. OBJECTIVE:This study aimed to identify the precision and reproducibility of measuring varus/valgus stress X-rays three-dimensionally and to examine varus/valgus stability
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Subcutaneous tissue reaction to a novel nano zinc oxide eugenol dental cement Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-11-24 Rohmat Nursin, Masitah Hayati Harun, Dasmawati Mohamad, Siti Khadijah Mohd Bakhori, Shahrom Mahmud
BACKGROUND:Zinc oxide eugenol (ZOE) cement is a popular dental material due mainly to its analgesic, antibacterial and anti-inflammatory effects. The formulation of ZOE cement from nano particle-sized zinc oxide (ZnO) has the potential to increase these properties as well as reduce its adverse effects to the surrounding tissues. OBJECTIVE:This study evaluated the subcutaneous tissue response towards
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Rapidly degradable konjac glucomannan hydrogels cross-linked with olsalazine for colonic drug release Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-09-13 Qiao Zhang, Huili Fu, Yunfei Zhang, Liang Li, Guoping Yan
BACKGROUND:Polysaccharide hydrogel is one of the most important materials for the colon target drug release system. However, the degradation time of polysaccharide hydrogel is much longer than the retention time in the colon. The drugs are expelled from the body before being released. OBJECTIVE:Inorder to match the degradation of drug carriers and their retention time in the colon, a rapidly degradable
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Enhanced mechanic properties of calcium phosphate cements via mussel-inspired adhesive as bone substitute: Highlights of their interactions Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-08-17 Rupan Yuan, Sijie Zhou, Xiong Xiong, Dan Yang, Donghu Lin, Taiyi Li, Bin He, Guihua Wei, Shuxin Qu
BACKGROUND:Inspired by natural bones, many organic components were added to Calcium Phosphate Cements (CPCs) to improve their mechanical strength. However, the strength of these composite CPCs is limited by the low strength of organic components itself and the weak interaction between organic components and CPCs. OBJECTIVE:Firstly, a composite CPC containing mussel-inspired adhesive, Poly-(Dopamine
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Surface hardening of Ti–Al–V superalloy spinal implant by using the boronization method Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-08-01 Mehdi Hekimoğlu, Hıdır Özer, Kamil Kiraz, Ceylan Onursal, Ferit Siyahcan, Ali Fahir Özer
BACKGROUND:We compared the raw Ti–Al–V super alloy transpedicular implant screws with boronized and surface-hardened transpedicular implant screws. OBJECTIVE:To improve patients’ postoperative prognosis with the production of harder and less fragile screws. METHODS:Surface hardening was achieved byapplying green-body encapsulation of the specimen with elemental boron paste which is sintered at elevated
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In vitro evaluation of BMSCs early proliferation on minocycline-loaded electrospun nanofibers membrane Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-08-01 Quan Liu, Xiao Ma, Yanchen Pei, Wendan Cheng, Zhengwei Wu
BACKGROUND:Electrospun nanofibers could simulate the natural extracellular matrix (ECM) of the host bone, while minocycline (MINO) is a broad-spectrum tetracycline antibiotic which has been found to have multiple non-antibiotics biological effects that promotes osteogenesis in vitro and in vivo. OBJECTIVE:The present study aims at constructing a polylactic acid (PLA) electrospun nanofiber membrane
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In vitro evaluation of crosslinked bovine pericardium as potential scaffold for the oral cavity Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-07-31 Guadalupe del Carmén Ordóñez-Chávez, Nayeli Rodríguez-Fuentes, Ricardo Peñaloza-Cuevas, José Manuel Cervantes-Uc, Luz Eugenia Alcántara-Quintana, Ixchel Araceli Maya-García, Virginia Aurora Herrera-Valencia, Celia Elena Mendiburu-Zavala
Abstract BACKGROUND: Bovine pericardium (BP) is a scaffold widely used in soft tissues regeneration; however, its calcification in contact with glutaraldehyde, represent an opportunity for its application in hard tissues, such as bone in the oral cavity. OBJECTIVE: To develop and to characterize decellularized and glutaraldehyde-crosslinked bovine pericardium (GC-BP) as a potential scaffold for guided
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Experimental characterization of motion resistance of the sacroiliac joint Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-07-31 Ryota Toyohara, Niels Hammer, Toshiro Ohashi
BACKGROUND:The human sacroiliac joint (SIJ) in vivo is exposed to compressive and shearing stress environment, given the joint lines are almost parallel to the direction of gravity. The SIJ supports efficient bipedal walking. Unexpected or unphysiological, repeated impacts are believed to cause joint misalignment and result in SIJ pain. In the anterior compartment of the SIJ being synovial, the articular
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Analysis of transjugular intrahepatic portosystemic shunt by hemodynamic simulation Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-07-18 Junjie Cao, Zhichao Yao, Guijun Huo, Zhanao Liu, Yao Tang, Jian Huang, Minxin Chen, Rui Ding, Liming Shen, Dayong Zhou
BACKGROUND:Transjugular intrahepatic portosystemic shunt (TIPS), which artificially creates a portocaval shunt to reduce portal venous pressure, has gradually become the primary treatment for portal hypertension (PH). However, there is no prefect shunting scheme in TIPS to balance the occurrence ofpostoperative complications and effective haemostasis. OBJECTIVE:To construct cirrhotic PH models and
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Mechanochemical synthesis of cerium chlorapatite from a mixture of cerium chloride heptahydrate, dicalcium phosphate dihydrate, and calcium hydroxide for biomedical application Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-07-05 Yuta Otsuka, Hiroshi Kono, Masafumi Kikuchi
BACKGROUND:Cerium ions promote osteoclastogenesis and activate bone metabolism, while cerium oxide nanoparticles exhibit potent anti-inflammatory properties, making them promising for biomedical applications. OBJECTIVE:The purpose of this study was to develop and evaluate a synthesis method for sustained-release cerium-ion bioceramics containing apatite. Substituted apatite was found to be an effective
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An extracellular matrix hydrogel from porcine urinary bladder for tissue engineering: In vitro and in vivo analyses Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-07-03 German Jiménez-Gastélum, Rosalío Ramos-Payán, Jorge López-Gutierrez, Alfredo Ayala-Ham, Erika Silva-Benítez, Mercedes Bermúdez, José Geovanni Romero-Quintana, Guzman Sanchez-Schmitz, Maribel Aguilar-Medina
BACKGROUND:The necessity to manufacture scaffolds with superior capabilities of biocompatibility and biodegradability has led to the production of extracellular matrix (ECM) scaffolds. Among their advantages, they allow better cell colonization, which enables its successful integration into the hosted tissue, surrounding the area to be repaired and their formulations facilitate placing it into irregular
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A comparative study of robot-assisted and traditional surgeries in the treatment of thoracolumbar fractures based on 1-year follow-up observation Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-07-03 Xu-Qi Hu, Hui-Gen Lu, Xiao Zhou, Min-Jie Hu, Xue-Kang Pan, Bao Chen, Ye-Feng Yu
BACKGROUND:There are conflicting results for robot-assisted (RA) pedicle screw fixation compared with freehand (FH) pedicle screw fixation. OBJECTIVE:This study was designed to retrospectively compare the accuracy and efficacy of RA percutaneous pedicle screw fixation and traditional freehand FH pedicle screw fixation in the treatment of thoracolumbar fractures. METHODS:A total of 26 cases were assigned
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Determining optimal length of coracoid graft in the modified bristow procedure for anterior shoulder instability: A three-dimensional finite element analysis Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-07-04 Hirotaka Sano, Tatsuro Komatsuda, Kazuhide Suzuki, Hiroo Abe, Hiroshi Ozawa, Jun Kumagai, Toshimitsu A. Yokobori Jr
BACKGROUND:There is a lack of consensus concerning the coracoid graft length in the modified Bristow procedure. OBJECTIVE:We attempted to determine the optimal graft length using the three-dimensional finite element method. METHODS:In a shoulder model with a 25% anterior glenoid defect, a coracoidgraft of varying lengths (5, 10, 15, and 20 mm) was fixed using a half-threaded screw. First, a compressive
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Preparation of drug-loaded microspheres with a core-shell structure using silk fibroin and poly lactic-co-glycolic acid and their application Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-07-03 Yi Zhang, Lu Wang, Bin Zhao
BACKGROUND:Advances in bone tissue engineering offer novel options for the regeneration of bone tissue. In the current clinical treatment, the method of accelerating bone tissue regeneration rate by promoting early angiogenesis has been widely accepted. OBJECTIVE:This study aimed to develop a long-acting slow-release system using the pro-angiogenic drug tetramethylpyrazine (TMPZ) and pro-osteogenic
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Evaluation of biocompatibility and angiogenic potential of extracellular matrix hydrogel biofunctionalized with the LL-37 peptide Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-06-28 Jorge López-Gutierrez, Rosalío Ramos-Payán, Jose Geovanni Romero-Quintana, Alfredo Ayala-Ham, Yolanda Castro-Salazar, Hipolito Castillo-Ureta, German Jiménez-Gastélum, Mercedes Bermúdez, Maribel Aguilar-Medina
BACKGROUND:Biomaterials must allow revascularization for a successful tissue regeneration process. Biomaterials formulated from the extracellular matrix (ECM) have gained popularity in tissue engineering because of their superior biocompatibility, and due to their rheological properties, ECM-hydrogels can be easily applied in damaged areas, allowing cell colonization and integration into the host tissue
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In situ-formed hyaluronan gel/BMP-2/hydroxyapatite composite promotes bone union in refractory fracture model mice Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-06-09 Hiroki Saito, Shintaro Shoji, Akiyoshi Kuroda, Gen Inoue, Ryo Tazawa, Hiroyuki Sekiguchi, Fukushima Kensuke, Masayuki Miyagi, Masashi Takaso, Kentaro Uchida
BACKGROUND:A combination of synthetic porous materials and BMP-2 has been used to promote fracture healing. For bone healing to be successful, it is important to use growth factor delivery systems that enable continuous release of BMP-2 at the fracture site. We previously reported that in situ-formed gels (IFGs) consisting of hyaluronan (HyA)-tyramine (TA), horseradish peroxidase and hydrogen peroxide
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Design modifications and evaluation of the silicone artificial finger joints Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-05-23 F.A. Alnaimat, H.A. Owida, Jamal I. Al-Nabulsi, B. Al-Naami, A. Al-Ghraibah, M. Al-Ayyad, Muneera Altayeb, Ashraf Al Sharah
BACKGROUND:There are many reasons that could lead to finger joint arthroplasty, and the most familiar reason is osteoarthritis. Silicone finger joint are the most commonly used implants. However, these implants might fracture with time and cause wear which will lead to chronic inflammation and synovitis for the patient and then implant failure. OBJECTIVE:The aim of this study is to improve the design
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VRE aided-diagnosis system for anxiety disorders: LSTM architecture for three levels of anxiety recognition Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-05-22 Wahida Handouzi, Choubeila Maaoui, Alain Pruski
BACKGROUND:The COVID-19 pandemic has resulted in increased psychological pressure on mental health since 2019. The resulting anxiety and stress have permeated every aspect of life during confinement. OBJECTIVE:To provide psychologists with an unbiased measure that can aid in the preliminary diagnosis of anxiety disorders and be used as an initial treatment in cognitive-behavioral therapy, this article
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Topological optimization of anterior cervical plate (ACP) and its biomechanic characteristics Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-05-19 Peng Ye, Rongchang Fu, Zhaoyao Wang
BACKGROUND:Currently, quadrilateral anterior cervical plate (QACP) is a highly prevalent ACP. OBJECTIVE:This study aims to design a novel ACP using topology optimization (TOACP). METHODS:A completed model for C1–C7 cervical segments was established and validated. QACP and TOACP cage systems were implanted within two cervical vertebrae models, respectively, and peak stresses and stress distributions
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Particulate beta-tricalcium phosphate and hydroxyapatite doped with silver promote in vitro osteoblast differentiation in MC3T3-E1 cells Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-04-20 Masanori Horie, Ryo Chiba, Shota Umemoto, Masahiko Tajika
BACKGROUND:Calcium phosphates including β-tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) have been widely used for bone regeneration application because of their high osteoconductive activities. In addition, various kinds of inorganic ions enhance differentiation, proliferation, and mineralization of osteoblasts. However, information about the effects of silver-doped β-TCP [β-TCP (Ag)] and HAp
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Numerical simulation of hemodynamics in patient-specific pulmonary artery stenosis Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-04-19 Fan He, Xinyu Wang, Lu Hua, Tingting Guo
BACKGROUND:The incidence rate of pulmonary artery stenosis is increasing year by year and its numerical simulation has become a key project of biomedical engineering. OBJECTIVE:The purpose of this work is to study the changes of hemodynamic parameters in patient-specific pulmonary artery stenosis.METHODS:A pulmonary artery stenosis model is established based on patient-specific computed tomography
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Effect of ellagic acid and retinoic acid on collagen and elastin production by human dermal fibroblasts Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-03-27 Chloe Duckworth, Jada Stutts, Kayla Clatterbuck, Nasim Nosoudi
BACKGROUND:Elastin is a fibrous protein key to the structure and support of skin as well as other organ tissues. Elastic fibers are located in the skin’s dermal layer and make up approximately 2%–4% of the fat-free dry weight of the dermis in the skin of adults. Aging causes the progressive degradation of elastin fibers. Loss of these fibers can cause skin sagging and wrinkling, loss of healthy blood
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Surface analysis of (Ti,Mg)N coated bone fixation devices following the rabbit femur surgery. Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-01-01 Kenda Sabouni,Yetkin Ozturk,Erkan Kacar,Gamze Torun Kose,Fatma Nese Kok,Muhammet Kursat Kazmanli,Mustafa Kamil Urgen,Sakip Onder
BACKGROUND Magnesium (Mg) enhances the bone regeneration, mineralization and attachment at the tissue/biomaterial interface. OBJECTIVE In this study, the effect of Mg on mineralization/osseointegration was determined using (Ti,Mg)N thin film coated Ti6Al4V based plates and screws in vivo. METHODS TiN and (Ti,Mg)N coated Ti6Al4V plates and screws were prepared using arc-PVD technique and used to fix
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3D printed mesoporous bioactive glass, bioglass 45S5, and β-TCP scaffolds for regenerative medicine: A comparative in vitro study Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-01-31 Maria Pacheco, John L. Ricci, Dindo Mijares, Timothy G. Bromage, Sasan Rabieh, Paulo G. Coelho, Lukasz Witek
BACKGROUND:While autografts to date remain the “gold standard” for bone void fillers, synthetic bone grafts have garnered attention due to their advantages such as ability to be tailored in terms of its physical and chemical properties. Bioactive glass (BG), an inorganic material, has the capacityto form a strong bond with bone by forming a bone-like apatite surface, enhancing osteogenesis. Coupled
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Antibiofilm properties of silver nanoparticles incorporated into polymethyl methacrylate used for dental applications Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-01-31 Marine Ortiz-Magdaleno, Luis Sánchez-Vargas, Delia Gardea-Contreras, Verónica Campos-Ibarra, Amaury Pozos-Guillén, Raúl Márquez-Preciado
BACKGROUND:Acrylic resins used in dental and biomedical applications do not have antimicrobial properties, their surface is susceptible to colonization of microorganisms. OBJECTIVE:The aim of this study was to evaluate the antibiofilm properties of silver nanoparticles (AgNPs) deposited in a polymethyl methacrylate (PMMA) surface against a Staphylococcus aureus biofilm. METHODS:The PMMA was impregnated
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The effect of medical biodegradable magnesium alloy in vivo degradation and bone response in a rat femur model with long-term fixation Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-01-30 Ying Zhang, Haijian Wang, Takashi Kumazawa, Dongying Ju
BACKGROUND:It is of great significance to understand the effect of the different corrosion behaviors of magnesium (Mg) alloys manufactured using different casting methods and implanted with different methods on the long-term implantation to expand the application of Mg-based biomedical implants. OBJECTIVE:The effects of four different casting and rolling speeds on the microstructure of an Mg–rare earth
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Human adipose-derived stem cells can optimize the filling material in rats Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-01-24 Siwei Qu, Ning Ma, Weixin Wang, Sen Chen, Qi Wu, Yangqun Li, Zhe Yang
BACKGROUND:Human adipose-derived stem cells have been identified as a promising candidate for cell-assisted therapy to improve graft survival. OBJECTIVE:To objective of the study was to add human adipose-derived stem cells into filling materials. METHODS:The filling materials were prepared and divided into 6 groups: fat particles with phosphate buffer saline or human adipose-derived stem cells; acellular
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Visualization of multiphase pulsatile blood over single phase blood flow in a patient specific stenosed left coronary artery using image processing technique Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2023-01-11 Abdulgaphur Athani, N.N.N. Ghazali, Irfan Anjum Badruddin, Sarfaraz Kamangar, N.J. Salman Ahmed, Abdulrazak Honnutagi
BACKGROUND:Coronary arteries disease has been reported as one of the principal roots of deaths worldwide. OBJECTIVE:The aim of this study is to analyze the multiphase pulsatile blood flow in the left coronary artery tree with stenosis. METHODS:The 3D left coronary artery model was reconstructed using 2D computerized tomography (CT) scan images. The Red Blood Cell (RBC) and varying hemodynamic parameters
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Reduced fibrous capsule elastic fibers from biologic ECM-enveloped CIEDs in minipigs, supported with a novel compression mechanics model Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-12-28 Roche C. de Guzman, Allison S. Meer, Aidan A. Mathews, Atara R. Israel, Michael T. Moses, Clarence M. Sams, Daniel B. Deegan
Abstract BACKGROUND: Fibrous capsules (Fb) in response to cardiovascular implantable electronic devices (CIEDs), including a pacemaker (P) system, can produce patient discomfort and difficulties in revision surgery due partially to their increased compressive strength, previously linked to elevated tissue fibers. OBJECTIVE: A preliminary study to quantify structural proteins, determine if biologic
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Effect of microwave polymerization on the thermomechanical and surface properties of ocular prosthetic acrylic resins Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-12-08 Luis Antonio Flores-Espinosa, José Federico Torres-Teran, Luis Octavio Sánchez-Vargas, Marine Ortiz-Magdaleno, José Amir Gonzalez-Calderón, Norma Verónica Zabala-Alonso, Vladimir Alonso Escobar-Barrios, Mariana Gutiérrez-Sanchez, Gregorio Sánchez-Balderas, José Elías Pérez-López
BACKGROUND:Polymerization conditions affect the physical-mechanical properties of acrylic resins used for craniofacial prostheses. OBJECTIVE:The aim of this study was to evaluate the effect of microwave polymerization on the thermomechanical properties and surface morphology of ocular prostheses fabricated with polymethyl methacrylate (PMMA). METHODS:PMMA discs were polymerized with microwave energy
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Numerical analysis of the effects of padded pelvic belts as a treatment for sacroiliac joint dysfunction Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-12-08 Ryota Toyohara, Takahiro Hiramukai, Daisuke Kurosawa, Niels Hammer, Toshiro Ohashi
Abstract BACKGROUND: Pain related to the sacroiliac joint (SIJ) accounts for low back pain in 15%–30% of patients. One of the most common treatment options is the use of pelvic belts. Various types of pelvic belts exist; however, the mechanisms underlying treatment and their effectiveness remain unclear to date. OBJECTIVE: To analyze stress distribution in the pelvis when a pelvic rubber belt or a
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Experimental study on co-culture of DiI-labeled rat bone marrow mesenchymal stem cells and neonatal rat cardiomyocytes to induce differentiation into cardiomyocyte-like cells Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-12-07 Junsheng Mu, Zichang Zhang, Fan Zhou, Jianwei Zheng, Ping Bo, Bin You
BACKGROUND:Myocardial infarction is a serious clinical disease with high mortality and poor prognosis. Cardiomyocytes (CMs) have limited regeneration abilities after ischemic injury. Their growth and differentiation can be enhanced by contact co-culture with stem cells. OBJECTIVE:The aim was to study the contact co-culture of Dil-labeled bone marrow mesenchymal stem cells (BMSCs) and CMs for inducing
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Impact of photodynamic therapy on the marginal adaptation of biodentine used as root-end filling material Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-12-07 Ivanka Dimitrova, Yaneta Kouzmanova
BACKGROUND:The marginal adaptation of root-end filling materials and the effective antibacterial control in a surgical site are crucial for the successful outcome of endodontic surgery. OBJECTIVE:This study aimed to evaluate the effect of retrograde application of photodynamic therapy on the marginal adaptation of Biodentine used as a root-end filling material. METHODS:Twenty single-rooted anterior
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An in vivo preclinical study assessing biocompatibility of Pd-based bulk metallic glass Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-10-19 Lukasz Witek, Vasudev Vivekanand Nayak, Ricardo Rodriguez Colon, Andrea Torroni, Marios D. Demetriou, Paulo G. Coelho
BACKGROUND:The bulk metallic glass (BMG), Pd79Ag3.5P6Si9.5Ge2, has a high fracture toughness and has been found to accommodate post-yield stress, unlike most other BMG. Moreover, due to its greater noble gas composition it has a intrinsic corrosion resistance, ideal for dental and orthopedic implants. OBJECTIVE:This present study aimed to evaluate the in vivo application of Pd79Ag3.5P6Si9.5Ge2 in a
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Optimized osteogenesis of biological hydroxyapatite-based bone grafting materials by ion doping and osteoimmunomodulation Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-10-07 Yihan Xing, Xinyi Zhong, Zhuofan Chen, Quan Liu
BACKGROUND:Biological hydroxyapatite (BHA)-based bone grafting materials have been widely used for bone regeneration in implant surgery. Much effort has been made in the improvement of their osteogenic property as it remains unsatisfactory for clinical use. Osteoimmunomodulation plays a significantrole in bone regeneration, which is highly related to active inorganic ions. Therefore, attempts have
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Dynamic effects of eifferent nail placement strategies on LenkeC scoliosis Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-10-04 Xianzheng Li, Rongchang Fu, Hui Wu, Yanli Sun
BACKGROUND:Although the internal fixation technique for scoliosis is effective, there is a great risk of nail placement in actual operation. OBJECTIVE:To compare the effects of three different nail placement strategies on LenkeC patients with scoliosis under cyclic loading. METHODS:Firstly, the finite element model was established by using CT scanning images and X-ray images of patients with LenkeC
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A comparative study of PSPVP and PSIBG in the treatment of stage II–III Kummell’s disease Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-10-06 Jian-Qiao Zhang, Zhong-You Zeng, Hui-Gen Lu, Wei Yu, Xu-Qi Hu, Wei-Shan Chen, Gang Chen
BACKGROUND:Percutaneous kyphoplasty (PKP) or percutaneous vertebroplasty (PVP) are commonly employed for Kummell’s disease in stages II–III; however, these techniques produce some complications. OBJECTIVE:To compare the clinical efficacy and imaging results of percutaneous vertebroplasty + bone cement-augmented short-segment pedicle screw fixation (PSPVP) versus transpedicular intracorporeal bone grafting
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Multiphase flow hemodynamic evaluation of vertebral artery stenosis lesions and plaque stability Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-10-06 Wei Ma, Zhiguo Cheng, Xiaoqin Chen, Chengdu Huang, Guanghao Yu, Guangxin Chen
BACKGROUND:Atherosclerosis is one of the main causes of vertebral artery stenosis, which reduces blood supply to the posterior circulation, resulting in cerebral infarction or death. OBJECTIVE:To investigate stenosis rates and locations on the development of vertebral artery plaques. METHODS:Stenosis models with varying degrees and positions of stenosis were established. The stenosis area was comprehensively
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Numerical analysis of hemodynamics in pulmonary artery stenosis Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-09-13 Fan He, Xinyu Wang, Lu Hua, Tingting Guo
BACKGROUND:Pulmonary artery stenosis is a serious threat to people’s life and health. OBJECTIVE:The hydrodynamic mechanism of pulmonary artery stenosis is investigated. METHODS:Numerical analysis of hemodynamics in pulmonary artery stenosis using computational fluid dynamics techniques is a well-established method. An idealized model of pulmonary stenosis is established, and the model is divided into
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Effect of super activated platelet lysate on cell proliferation, repair and osteogenesis Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-09-14 Xiaorui Guo, Chunxiang Liu, Yi Zhang, Liangjia Bi
BACKGROUND:Platelet lysate (PL) is considered as an alternative to fetal bovine serum (FBS) and facilitates the proliferation and differentiation of mesenchymal cells. OBJECTIVE:The aim of this study is to explore whether super activated platelet lysate (sPL), a novel autologous platelet lysate, has the ability to inhibit inflammation and promote cell proliferation, repair and osteogenesis as a culture
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Visual evaluation for the elasticity of suprahyoid muscles using sonographic elastography during tongue pressure measurement in healthy adult subjects: A pilot study Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-09-13 Sachiko Hayashi-Sakai, Taichi Kobayashi, Takafumi Hayashi, Junko Shimomura-Kuroki, Jun Sakai, Makoto Sakamoto
BACKGROUND:Suprahyoid muscles behavior during the tongue lifting movement has not yet been elucidated. OBJECTIVE:The purpose of this study was to investigate the potential of elastography imaging to examine developmental oral dysfunction in children and oral hypofunction in older adults using sonography. METHODS:Tongue pressure was measured using a manometer with a probe. The tongue pressure was measured
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Evaluation of different remineralization agents in the treatment of natural caries-affected dentin in permanent teeth Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-09-13 Ece Yilmazkasapoglu Turkay, Betul Kargul, Aysu Karakas Aydinoglu, Afife Binnaz Hazar Yoruc
BACKGROUND:In the preventive treatment protocol, providing remineralization of the tissue in demineralized dentin caries is an important step. OBJECTIVE:In this in vitro study, the effectiveness of remineralization agents in natural caries-affected dentin (NCAD) were investigated. METHODS:Forty caries slices were prepared from permanent molar dentin with International Caries Detection and Assessment
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Preparation characterization and blood compatibility studies of silk fibroin/gelatin/curcumin injectable hydrogels Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-08-19 Kassahun Alula, Terin Adali, Oğuz Han Ebedal
BACKGROUND:Hydrogel is a three-dimensional structure that has the potential to absorb and retain water within the mesh of its porous network structure. Currently hydrogels made from natural biopolymers are preferred in the discipline of biomedical applications because of their blood compatibility,adhesion of platelets and protein binding, ease of administration and delivery of ingredients to the place
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In vivo degradation and bone reaction of long-term fixation with a magnesium alloy made by twin-roll casting in a rat femur model Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-08-19 Ying Zhang, Haijian Wang, Takashi Kumazawa, Dongying Ju
BACKGROUND:The effect of casting parameters on the microstructure and corrosion resistance of Mg alloys is still limited, especially in clinical animal experiments. OBJECTIVE:We prepared a new magnesium rare earth alloy (Mg-Re, where Re is Ce or La) by vertical two-roll casting and Mg-A by furtherrolling. The microstructure characteristics, degradation behavior, and bone reaction of the two alloys
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Analysis of shear stress related hemolysis in a ventricular assist device Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-08-18 Mohamed Bounouib, Hind Benakrach, Mourad Taha-Janan, Wajih Maazouzi
BACKGROUND:Implantable devices such as ventricular assist devices provide appropriate treatment for patients with advanced heart failure. Unfortunately these devices still have many problems, particularly related to blood damage. OBJECTIVE:The aim of this research is to examine two new ventricularassist devices in terms of induced shear stress, exposure time, and induced hemolysis. METHOD:Reverse engineering
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Biomechanical effect of fibular osteotomy on the knee joint in high tibial osteotomy: A cadaveric study Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-07-18 Osamu Tanifuji, Tomoharu Mochizuki, Yoshio Koga, Yuji Tanabe, Hiroyuki Kawashima
BACKGROUND:Closed-wedge high tibial osteotomy (CWHTO) with a fibular osteotomy (FO) causes medial joint space widening in the knee. However, the effect of FO on the joint space width remains unclear. OBJECTIVE:This study aimed to examine the effect of FO on the knee in HTO. METHODS:A compression load test was performed on two amputated human limbs under four conditions: (1) normal (without any osteotomy)
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M1 to M2 induction in macrophages using a retinoic acid-releasing mesenchymal stem cell scaffold Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-07-18 Kaivon D. Assani, Nasim Nosoudi, Jaime E. Ramirez-Vick, Surinder P. Singh
Modulation of macrophage polarization is required for effective tissue repair and regenerative therapies. Therapeutic modulation of macrophages from an inflammatory M1 to a fibrotic M2 phenotype could help in diseases, such as chronic wounds, which are stalled in a prolonged and heightened inflammatory stage within the wound healing process. This study evaluates the efficiency of a pullulan/gelatin
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Effect of inoculation density of bone marrow mesenchymal stem cells cultured on calcium phosphate cement scaffold on osteogenic differentiation Bio-Medical Mater. Eng. (IF 1.0) Pub Date : 2022-07-18 Guangjun Li, Wen Shen, Minghui Chu, Guowei Mo, Liqin Yao, Weidong Xu
BACKGROUND:Calcium phosphate cements (CPCs) are biocompatible materials that have been evaluated as scaffolds in bone tissue engineering. At present, the stem cell density of inoculation on CPC scaffold varies. OBJECTIVE:The aim of this study is to analyze the effect of seeding densities on cell growth and osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs) on a calcium phosphate