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A nontoxic strontium nanoparticle that holds the potential to act upon osteocompetent cells: An in vitro and in vivo characterization J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-16 Larwsk Hayann, Vitor Freire da Rocha, Marina Ferreira Cândido, Raphael Martini Vicente, Luiz H. S. Andrilli, Sandra Y. Fukada, María Sol Brassesco, Pietro Ciancaglini, Edgard Eduard Engel, Ana Paula Ramos
Estrogen deficiency, long‐term immobilization, and/or aging are commonly related to bone mass loss, thus increasing the risk of fractures. One option for bone replacement in injuries caused by either traumas or pathologies is the use of orthopedic cement based on polymethylmethacrylate (PMMA). Nevertheless, its reduced bioactivity may induce long‐term detachment from the host tissue, resulting in the
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pO2 reporter composite hydrogel macroencapsulation devices for magnetic resonance imaging oxygen quantification J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-16 Amy E. Emerson, Yuka Sugamura, Jad Mazboudi, Tuhfah M. Abdallah, Charmayne D. Seaton, Azin Ghasemi, Vikram D. Kodibagkar, Jessica D. Weaver
Hydrogel cell encapsulation devices are a common approach to reduce the need for chronic systemic immunosuppression in allogeneic cell product transplantation. Macroencapsulation approaches are an appealing strategy, as they maximize graft retrievability and cell dosage within a single device; however, macroencapsulation devices face oxygen transport challenges as geometries increase from preclinical
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Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-15 Kaitlin Mrksich, Marshall S. Padilla, Ryann A. Joseph, Emily L. Han, Dongyoon Kim, Rohan Palanki, Junchao Xu, Michael J. Mitchell
RNA‐based therapeutics have gained traction for the prevention and treatment of a variety of diseases. However, their fragility and immunogenicity necessitate a drug carrier. Lipid nanoparticles (LNPs) have emerged as the predominant delivery vehicle for RNA therapeutics. An important component of LNPs is the ionizable lipid (IL), which is protonated in the acidic environment of the endosome, prompting
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Mesenchymal stem cell‐secretome laden photopolymerizable hydrogels for wound healing J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-15 Riddhesh B. Doshi, Devashree Vakil, Thomas G. Molley, Md Shariful Islam, Kristopher A. Kilian, Corey Cunningham, Kuldip S. Sidhu
Mesenchymal stem cell‐derived secretome represents an emerging acellular therapeutic which possess significant opportunity for clinical applications due to its anti‐inflammatory, immunomodulatory, and wound healing properties. However, maintaining therapeutic efficacy and ensuring stability of cell‐based products is challenging, requiring a robust delivery method. Therefore, we designed a hydrogel‐based
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Extrusion 3D‐printed tricalcium phosphate‐polycaprolactone biocomposites for quercetin‐KCl delivery in bone tissue engineering J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-13 Connor Toulou, Vishal Sharad Chaudhari, Susmita Bose
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Impact of crystalline domains on long‐term stability and mechanical performance of anisotropic silk fibroin sponges J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-12 Elizabeth L. Aikman, Asha P. Rao, Yinhao Jia, Emily E. Fussell, Kayleigh E. Trumbull, Janani Sampath, Whitney L. Stoppel
Sponge‐like materials made from regenerated silk fibroin biopolymers are a tunable and advantageous platform for in vitro engineered tissue culture and in vivo tissue regeneration. Anisotropic, three‐dimensional (3D) silk fibroin sponge‐like scaffolds can mimic the architecture of contractile muscle. Herein, we use silk fibroin solution isolated from the cocoons of Bombyx mori silkworms to form aligned
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In vitro and in vivo evaluation of the osseointegration capacity of a polycarbonate‐urethane zirconium‐oxide composite material for application in a focal knee resurfacing implant J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-11 Pieter P. W. van Hugten, Ralph M. Jeuken, Erkan E. Asik, Henk Oevering, Tim J. M. Welting, Corrinus C. van Donkelaar, Jens C. Thies, Peter J. Emans, Alex K. Roth
Currently available focal knee resurfacing implants (FKRIs) are fully or partially composed of metals, which show a large disparity in elastic modulus relative to bone and cartilage tissue. Although titanium is known for its excellent osseointegration, the application in FKRIs can lead to potential stress‐shielding and metal implants can cause degeneration of the opposing articulating cartilage due
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In vivo healing of low temperature deproteinized bovine bone xenograft in a rabbit cranial model J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-11 Dina Abdelmoneim, Dawn Elizabeth Coates, Patrick Schmidlin, Sander Botter, Kai Chun Li, Gemma Claire Porter, Benedict Seo, Warwick John Duncan
The physicochemical properties of grafting materials affect the quality of the osteointegration, resorption rate, and the new bone (NB) formation. This study assessed the physicochemical properties and integration of a low temperature deproteinized bovine bone xenograft (BBX), referred to as optimized MoaBone® (OMB). This novel BBX was physiochemically characterized both pre and post chemical bleaching
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Cover Image J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-11 Brett Stern, Peter Monteleone, Janet Zoldan
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Bioactive poly(salicylic acid)‐poly(citric acid) scaffolds improve diabetic wound repair via regulating HIF‐1α, Nrf2 and macrophage J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-10 Chenxi Xie, Junping Ma, Meng Luo, Yidan Wang, Bo Lei
Diabetic wounds environment is over‐oxidized, over‐inflammatory, leading to difficulties in regenerating blood vessels, and retardation of healing in diabetic wounds. Therefore, diabetic wounds can be treated from the perspective of scavenging oxidative free radicals and reducing the level of inflammation. Herein, we report a bioactive poly(salicylic acid)‐poly(citric acid) (FPSa‐PCG) hydrogel for
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Preparation of calcium phosphate ion clusters through atomization method for biomimetic mineralization of enamel J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-10 Haide Dong, Lin Qiu, Chen Zhu, Wuzhe Fan, Li Liu, Quanfu Deng, Huan Zhang, Weihu Yang, Kaiyong Cai
Dental enamel is a mineralized extracellular matrix, and enamel defect is a common oral disease. However, the self‐repair capacity of enamel is limited due to the absence of cellular components and organic matter. Efficacy of biomimetic enamel mineralization using calcium phosphate ion clusters (CPICs), is an effective method to compensate for the limited self‐healing ability of fully developed enamel
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Improving regulatory T cell production through mechanosensing J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-07 Lingting Shi, Jee Yoon Lim, Lance C. Kam
Induced Tregs (iTregs) have great promise in adoptive immunotherapy for treatment of autoimmune diseases. This report investigates the impacts of substrate stiffness on human Treg induction, providing a powerful yet simple approach to improving production of these cells. Conventional CD4+ human T cells were activated on materials of different elastic modulus and cultured under suppressive conditions
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Expression of concern: Different apoptosis modalities in periprosthetic membranes J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-06
Maurizio Sabbatini , Valentina Piffanelli , Francesca Boccafoschi , Silvia Gatti , Filippo Renò , Michela Bosetti , Massimiliano Leigheb , Alessandro Massè , Cannas Mario , , Biomed. Mater. Res., 92A: 175–184. DOI: 10.1002/jbm.a.32349.The journal publishes this Expression of Concern to notify the readers regarding irregularities identified in Figure 1A and 1B of the above article, published online
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Mineral matrix deposition of MC3T3‐E1 pre‐osteoblastic cells exposed to silicocarnotite and nagelschmidtite bioceramics: In vitro comparison to hydroxyapatite J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-04 July Andrea Rincón‐López, Jennifer Andrea Hermann‐Muñoz, Rainer Detsch, Raúl Rangel‐López, Juan Muñoz‐Saldaña, Sergio Jiménez‐Sandoval, Juan Manuel Alvarado‐Orozco, Aldo R. Boccaccini
This work presents the effect of the silicocarnotite (SC) and nagelschmidtite (Nagel) phases on in vitro osteogenesis. The known hydroxyapatite of biological origin (BHAp) was used as a standard of osteoconductive characteristics. The evaluation was carried out in conventional and osteogenic media for comparative purposes to assess the osteogenic ability of the bioceramics. First, the effect of the
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3D printing of gellan‐dextran methacrylate IPNs in glycerol and their bioadhesion by RGD derivatives J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-04 Luca Paoletti, Francesco Baschieri, Claudia Migliorini, Chiara Di Meo, Olivier Monasson, Elisa Peroni, Pietro Matricardi
The ever‐growing need for new tissue and organ replacement approaches paved the way for tissue engineering. Successful tissue regeneration requires an appropriate scaffold, which allows cell adhesion and provides mechanical support during tissue repair. In this light, an interpenetrating polymer network (IPN) system based on biocompatible polysaccharides, dextran (Dex) and gellan (Ge), was designed
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Fabrication of vascularized tissue‐engineered bone models using triaxial bioprinting J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-27 Junbiao Zhang, Srisurang Suttapreyasri, Chidchanok Leethanakul, Bancha Samruajbenjakun
Bone tissue is a highly vascularized tissue. When constructing tissue‐engineered bone models, both the osteogenic and angiogenic capabilities of the construct should be carefully considered. However, fabricating a vascularized tissue‐engineered bone to promote vascular formation and bone generation, while simultaneously establishing nutrition channels to facilitate nutrient exchange within the constructs
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A novel porous titanium with engineered surface for bone defect repair in load‐bearing position J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-27 Wei Liu, Dong Wang, Guo He, Tingting Li, Xianlong Zhang
Porous titanium exhibits low elastic modulus and porous structure is thought to be a promising implant in bone defect repair. However, the bioinert and low mechanical strength of porous titanium have limited its clinical application, especially in load‐bearing bone defect repair. Our previous study has reported an infiltration casting and acid corrosion (IC‐AC) method to fabricate a novel porous titanium
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Lithium‐loaded GelMA‐Phosphate glass fibre constructs: Implications for astrocyte response J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-24 Zalike Keskin‐Erdogan, Nandin Mandakhbayar, Gang Shi Jin, Yu‐Meng Li, David Y. S. Chau, Richard M. Day, Hae‐Won Kim, Jonathan C. Knowles
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2024 as a year of growth for the Journal of Biomedical Materials Research Part A J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-21 J. Kent Leach
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Enhanced osteogenic and bactericidal performance of premixed calcium phosphate cement with photocrosslinked alginate thin film J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-21 Xiulin Shu, Junda Liao, Qian Wang, Lingling Wang, Qingshan Shi, Xiaobao Xie
The increasing prevalence of implant‐associated infections (IAI) in orthopedics remains a public health challenge. Calcium phosphates (CaPs) are critical biomaterials in dental treatments and bone regeneration. It is highly desirable to endow CaPs with antibacterial properties. To achieve this purpose, we developed a photocrosslinked methacrylated alginate co‐calcium phosphate cement (PMA‐co‐PCPC)
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Polymerized cyclodextrin microparticles for sustained antibiotic delivery in lung infections J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-21 Tracey L. Bonfield, Sean T. Zuckerman, Morgan T. Sutton, Julius N. Korley, Horst A. von Recum
Pulmonary infections complicate chronic lung diseases requiring attention to both the pathophysiology and complexity associated with infection management. Patients with cystic fibrosis (CF) struggle with continuous bouts of pulmonary infections, contributing to lung destruction and eventual mortality. Additionally, CF patients struggle with airways that are highly viscous, with accumulated mucus creating
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Assessment of the proteome profile of decellularized human amniotic membrane and its biocompatibility with umbilical cord‐derived mesenchymal stem cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-21 Kainat Ahmed, Haadia Tauseef, Jahan Ara Ainuddin, Muneeza Zafar, Irfan Khan, Asmat Salim, Munazza Raza Mirza, Omair Anwar Mohiuddin
Extracellular matrix‐based bio‐scaffolds are useful for tissue engineering as they retain the unique structural, mechanical, and physiological microenvironment of the tissue thus facilitating cellular attachment and matrix activities. However, considering its potential, a comprehensive understanding of the protein profile remains elusive. Herein, we evaluate the impact of decellularization on the human
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The effect of bioactivity of airway epithelial cells using methacrylated gelatin scaffold loaded with exosomes derived from bone marrow mesenchymal stem cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-16 Yongsen Li, Zhike Chen, Tian Xia, Haoxin Wan, Yi Lu, Cheng Ding, Fangbiao Zhang, Ziqing Shen, Shu Pan
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3D printing modality effect: Distinct printing outcomes dependent on selective laser sintering (SLS) and melt extrusion J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-13 Jeong Hun Park, Sarah Jo Tucker, Jeong-Kee Yoon, YongTae Kim, Scott J. Hollister
A direct and comprehensive comparative study on different 3D printing modalities was performed. We employed two representative 3D printing modalities, laser- and extrusion-based, which are currently used to produce patient-specific medical implants for clinical translation, to assess how these two different 3D printing modalities affect printing outcomes. The same solid and porous constructs were created
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Degradation protection and enhanced biocompatibility of Mg alloys pretreated with plasma proteins J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-08 Xian Wei, Jiajia Meng, Sujie Ma, Yanchun Li, Hong Qing, Xubiao Peng, Qing Zhao
After implantation of the Mg alloy in the human body, the adsorption of plasma protein on surface will cause a series of cell reactions and affect the degradation of Mg alloys. Herein, in vitro biological reactions of the ZK60 and AZ31 Mg alloys are analyzed in plasma protein environment. Combined with mass spectrometry analysis of the type of adsorbed proteins, it is shown that proteins such as fibrinogen
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Ultrasmall polyvinylpyrrolidone-modified iridium nanoparticles with antioxidant and anti-inflammatory activity for acute pancreatitis alleviation J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-06 Wenzhang Jin, Xueting Xie, Shuqi Shen, Xingjian Zhou, Shunfu Wang, Lijiang Zhang, Xiang Su
Acute pancreatitis (AP) is a common and serious acute inflammatory disease with high severity rate and mortality. Inflammation and oxidative stress play an extremely important role in the development of AP disease. Polyvinylpyrrolidone-modified iridium nanoparticles (IrNP-PVP) have multienzyme mimetic activity, and the aim of this article is to discuss the therapeutic alleviative effects of the ultrasmall
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Wharton's jelly-derived multifunctional hydrogels: New tools to promote intervertebral disc regeneration in vitro and ex vivo J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-03 Letizia Penolazzi, Anna Chierici, Maria Pina Notarangelo, Beatrice Dallan, Gina Lisignoli, Elisabetta Lambertini, Pantaleo Greco, Roberta Piva, Claudio Nastruzzi
The degeneration of intervertebral disc (IVD) is a disease of the entire joint between two vertebrae in the spine caused by loss of extracellular matrix (ECM) integrity, to date with no cure. The various regenerative approaches proposed so far have led to very limited successes. An emerging opportunity arises from the use of decellularized ECM as a scaffolding material that, directly or in combination
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Characterization of aTiO2 surfaces functionalized with CAP-p15 peptide J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-01-29 Guadalupe Ureiro-Cueto, Sandra E. Rodil, Maricela Santana-Vázquez, Lia Hoz-Rodriguez, Higinio Arzate, Gonzalo Montoya-Ayala
Functionalization of Titanium implants using adequate organic molecules is a proposed method to accelerate the osteointegration process, which relates to topographical, chemical, mechanical, and physical features. This study aimed to assess the potential of a peptide derived from cementum attachment protein (CAP-p15) adsorbed onto aTiO2 surfaces to promote the deposition of calcium phosphate (CaP)
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Hydrogel foam dressings with angiogenic and immunomodulatory factors from mesenchymal stem cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-01-25 Ziyang Lan, Alan Fletcher, Elizabeth C. Bender, Wenbai Huang, Laura J. Suggs, Elizabeth Cosgriff-Hernandez
Stem cell therapy and skin substitutes address the stalled healing of chronic wounds in order to promote wound closure; however, the high cost and regulatory hurdles of these treatments limit patient access. A low-cost method to induce bioactive healing has the potential to substantially improve patient care and prevent wound-induced limb loss. A previous study reported that bioactive factors derived
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Fluoride-treated rare earth-free magnesium alloy ZK30: An inert and bioresorbable material for bone fracture treatment devices J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-01-18 Hirotaka Watanabe, Wei Xu, Haruka Uno, Yuki Uraya, Masanori Kugita, Yoshihiro Komohara, Takuro Niidome, Makoto Sasaki, Ichiro Shimizu, Nobuyuki Fujita, Yusuke Kawano
Bone fractures represent a common health problem, particularly in an increasingly aging population. Bioresorbable magnesium (Mg) alloy-based implants offer promising alternatives to traditional metallic implants for the treatment of bone fractures because they eliminate the need for implant removal after healing. The Mg-Y-rare-earth (RE)-Zr alloy WE43, designed for orthopedic implants, has received
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Structure and properties of the acellular porcine cornea irradiated with 60Co-γ and electron beam and its histocompatibility J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-30 Qing Li, Yajun Sun, Haibin Zhao, Fan Zhang, Yu Guo, Xin Chen, Guoqun Zhao
Acellular porcine cornea (APC) has been used in corneal transplantation and treatment of the corneal diseases. Sterilization is a key step before the application of graft, and irradiation is one of the most commonly used methods. In this paper, APC was prepared by the physical freeze-thawing combined with biological enzymes, and the effects of the electron beam (E-beam) and cobalt 60 (60Co-γ) at the
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Medical grade 3D printable bioabsorbable PLDL/Mg and PLDL/Zn composites for biomedical applications J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-25 Cillian Thompson, Guillermo Domínguez, Pilar Bardisa, Yuyao Liu, Juan Pedro Fernández-Blázquez, José Sánchez del Río, Monica Echeverry-Rendon, Carlos González, Javier Llorca
Medical grade PLDL, PLDL/Mg and PLDL/Zn filaments were manufactured by a dual extrusion method and used to prepare coupons and scaffolds with controlled porosity by fused filament fabrication. The mechanical properties, degradation mechanisms and biological performance were carefully analyzed. It was found that the presence of 4 vol.% of Mg and Zn particles did not substantially modify the mechanical
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Vascularization of PEGylated fibrin hydrogels increases the proliferation of human iPSC-cardiomyocytes J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-28 Ethan J. Vanderslice, Staunton G. H. Golding, Jeffrey G. Jacot
Studies have long sought to develop engineered heart tissue for the surgical correction of structural heart defects, as well as other applications and vascularization of this tissue has presented a challenge. Recent studies suggest that vascular cells and a vascular network may have regenerative effects on implanted cardiomyocytes (CM) and nearby heart tissue separate from perfusion of oxygen and nutrients
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Transglutaminase enables highly hydrolytically and proteolytically stable crosslinking of collagen on titanium surfaces and promotes osteogenic differentiation of human mesenchymal stem cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-26 Alena L. Palkowitz, Sascha Rüger, Maximilian Ziegler, Eva Miriam Buhl, Horst Fischer
Collagen with its bioactive ligand motives would be predestined as coating on bone implant surfaces like titanium hip stems to facilitate receptor-mediated cell adhesion and thereby improve early osseointegration. Unfortunately, collagen as coating exhibits very low proteolytic resistance in vivo. To overcome this limitation, different crosslinking methods of collagen (transglutaminase, GTA, EDC/NHS
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Special issue: Frontiers in biomaterials for cardiovascular health J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-21 Chris A. Bashur, Ngan F. Huang
The field of cardiovascular biomaterials offers the potential for development of therapeutic products to treat cardiovascular diseases. Among their uses, biomaterials enable tunable and localized delivery of therapeutic cargo, exert immunomodulatory effects, and provide three-dimensional environments that support tissue engineering and morphogenesis. Recent annual meetings of the Society for Biomaterials
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ROS-mediated anticancer effects of EGFR-targeted nanoceria J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-12 Kochurani K. Johnson, Pramod Koshy, Chantal Kopecky, Michelle Devadason, Joanna Biazik, Xiaoran Zheng, Yue Jiang, Xiaochun Wang, Yiling Liu, Jeff Holst, Jia-Lin Yang, Kristopher A. Kilian, Charles C. Sorrell
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Hydrogel-polyurethane fiber composites with enhanced microarchitectural control for heart valve replacement J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-29 Andrew Robinson, Abbey Nkansah, Sanchita Bhat, Shweta Karnik, Sarah Jones, Ashauntee Fairley, Jonathan Leung, Megan Wancura, Michael S Sacks, Lakshmi Prasad Dasi, Elizabeth Cosgriff-Hernandez
Polymeric heart valves offer the potential to overcome the limited durability of tissue based bioprosthetic valves and the need for anticoagulant therapy of mechanical valve replacement options. However, developing a single-phase material with requisite biological properties and target mechanical properties remains a challenge. In this study, a composite heart valve material was developed where an
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Varying the RGD concentration on a hyaluronic acid hydrogel influences dormancy versus proliferation in brain metastatic breast cancer cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-28 Kasra Goodarzi, Rachel Lane, Shreyas S. Rao
A majority of breast cancer deaths occur due to metastasis of cancer cells to distant organs. In particular, brain metastasis is very aggressive with an extremely low survival rate. Breast cancer cells that metastasize to the brain can enter a state of dormancy, which allows them to evade death. The brain microenvironment provides biophysical, biochemical, and cellular cues, and plays an important
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Crosslinking strategies of decellularized extracellular matrix in tissue regeneration J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-22 Su Qiao, Tan Peijie, Jiang Nan
By removing the immunogenic cellular components through various decellularization methods, decellularized extracellular matrix (dECM) is considered a promising material in the field of tissue engineering and regenerative medicine with highly preserved physicochemical properties and superior biocompatibility. However, decellularization treatment can lead to some loss of structural integrity, mechanical
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Preparation and characterization of a novel composite acellular matrix/hyaluronic acid thermosensitive hydrogel for interstitial cystitis/bladder pain syndrome J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-16 Wei Guo, Haichao Liu, Jiaxing Zhang, Jianzhong Zhang, Fei Wang, Peng Zhang, Yunbo Yang
Bladder mucosa damage that causes harm to the interstitium is a recognized pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS). The intravesical instillation of drugs is an important second-line therapy, but it is often necessary to use drugs repeatedly in the clinic because of their short residence time in the bladder cavity, which alters the therapeutic effect. To overcome this drawback
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Extrusion 3D-printing and characterization of poly(caprolactone fumarate) for bone regeneration applications J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-16 Bipin Gaihre, Maria D. Astudillo Potes, Xifeng Liu, Maryam Tilton, Emily Camilleri, Asghar Rezaei, Vitalii Serdiuk, Sungjo Park, Fabrice Lucien, Andre Terzic, Lichun Lu
Polycaprolactone fumarate (PCLF) is a cross-linkable PCL derivative extensively considered for tissue engineering applications. Although injection molding has been widely used to develop PCLF scaffolds, platforms developed using such technique lack precise control on architecture, design, and porosity required to ensure adequate cellular and tissue responses. In particular, the scaffolds should provide
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The development of a nucleus pulposus-derived cartilage analog scaffold for chondral repair and regeneration J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-14 Vishal Joseph Thomas, Nathan Foster Buchweitz, Jay John Baek, Yongren Wu, Jeremy John Mercuri
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Freeze casting of hydroxyapatite-titania composites for bone substitutes J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-14 Tony J. Yin, Samantha K. Steyl, Jerry Howard, Krista Carlson, Sujee Jeyapalina, Steven E. Naleway
Hydroxyapatite (HA) is commonly used as a bone substitute material, but it lacks mechanical strength when compared to native bone tissues. To improve the efficacy of HA as a bone substitute by improving the mechanical strength and cell growth attributes, porous composite scaffolds of HA and titania (HA-TiO2) were fabricated through a freeze-casting process. Three different compositions by weight percent
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Oriented polyaniline/poly-l-lactic acid/gelatin nanofiber scaffolds promote outgrowth of spiral ganglion neurons J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-14 Li Liu, Mengyu Chen, Junming Zhang, Haobo Li, Zhaoxia Li, Jianhao Song, Shutao Ma, Yingjie Wang, Xiangxin Lou
Sensorineural hearing loss (SNHL) is caused by the loss of sensory hair cells (HCs) and/or connected spiral ganglion neurons (SGNs). The current clinical conventional treatment for SNHL is cochlear implantation (CI). The principle of CI is to bypass degenerated auditory HCs and directly electrically stimulate SGNs to restore hearing. However, the effectiveness of CI is limited when SGNs are severely
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Enhancement of in vitro antibacterial activity and bioactivity of iodine-loaded titanium by micro-scale regulation using mixed-acid treatment J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-13 Yasuhisa Sawai, Seiji Yamaguchi, Kazuya Inoue, Nahoko Kato-Kogoe, Kazuto Yamada, Nanako Shimada, Morihiro Ito, Hiroyuki Nakano, Takaaki Ueno
Postoperative infection and subsequent device loss are serious complications in the use of titanium dental implants and plates for jawbone reconstruction. We have previously reported that NaOH–CaCl2–thermal–ICl3–treated titanium (NaCaThIo) has a nano-scale surface and exhibits antibacterial activity against Staphylococcus aureus. The present study examined the surface properties of mixed-acid treated
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Dynamic control of contractile resistance to iPSC-derived micro-heart muscle arrays J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-12 David Schuftan, Yasaman Kargar Gaz Kooh, Jingxuan Guo, Yuwen Sun, Lavanya Aryan, Bryce Stottlemire, Cory Berkland, Guy M. Genin, Nathaniel Huebsch
Many types of cardiovascular disease are linked to the mechanical forces placed on the heart. However, our understanding of how mechanical forces exactly affect the cellular biology of the heart remains incomplete. In vitro models based on cardiomyocytes derived from human induced pluripotent stem cells (iPSC-CM) enable researchers to develop medium to high-throughput systems to study cardiac mechanobiology
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Endotoxin reduction from biotech silk material inhibits the production of anti-silk antibodies in mice J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-09 Tomasz Deptuch, Kamil Kucharczyk, Anna Florczak, Hanna Dams-Kozlowska
Eliminating endotoxins is a common problem in the development of biotechnologically produced pharmaceuticals or biomaterials. Residual endotoxins in the final sample may hamper the properties of the product or induce severe adverse effects. Developing an effective downstream purification protocol that ensures a lack of minimal endotoxin content in the final product can be a challenging task. In our
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Using anti-PD-L1 antibody conjugated gold nanoshelled poly (Lactic-co-glycolic acid) nanocapsules loaded with doxorubicin: A theranostic agent for ultrasound imaging and photothermal/chemo combination therapy of triple negative breast cancer J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-09 Hui Jiang, Yingying Zhou, Dongdong Zheng, Yexiazi Cheng, Dacheng Xiang, Lixin Jiang, Jing Du
Triple negative breast cancer (TNBC) has the worst prognosis of all breast cancers, and it is difficult to progress through traditional chemotherapy. Therefore, the treatment of TNBC urgently requires agents with effective diagnostic and therapeutic capabilities. In this study, we obtained programmed death-ligand 1 (PD-L1) antibody conjugated gold nanoshelled poly(lactic-co-glycolic acid) (PLGA) nanocapsules
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Crosslinking chitosan with glucose via the modified Maillard reaction promotes the osteoinduction of mouse MC3T3-E1 pre-osteoblasts J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-07 Kuo-Chin Huang, Ding-Yu Lee, Po-Yao Chuang, Tien-Yu Yang, Yu-Ping Su, Shun-Fu Chang
Bone defects are a common clinical issue, but therapeutic efficiency can be challenging in cases of more considerable traumas or elderly patients with degenerated physiological metabolism. To address this issue, a more suitable cell-biomaterial construct promoting bone regeneration has been extensively investigated, with the chitosan scaffold being considered a potential candidate. In this study, chitosan
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Controlled release of therapeutic antibody using hydrolytically degradable microgels J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-05 Ana Mora-Boza, Zakir Ahmedin, Andrés J. García
Monoclonal antibodies have gained significant interest as potential therapeutics for treating various diseases. However, these therapies are not always effective due to poor treatment compliance associated with multiple administrations and drug resistance. Thus, there is a growing interest in developing advanced monoclonal antibody delivery systems that can customize pharmacokinetics to enhance therapeutic
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Establishment of a tissue-engineered colon cancer model for comparative analysis of cancer cell lines J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-05 Iman Hassani, Benjamin Anbiah, Andrew L. Moore, Peter T. Abraham, Ifeoluwa A. Odeniyi, Nicole L. Habbit, Michael W. Greene, Elizabeth A. Lipke
To overcome the limitations of in vitro two-dimensional (2D) cancer models in mimicking the complexities of the native tumor milieu, three-dimensional (3D) engineered cancer models using biomimetic materials have been introduced to more closely recapitulate the key attributes of the tumor microenvironment. Specifically, for colorectal cancer (CRC), a few studies have developed 3D engineered tumor models
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The influence of pH and salt concentration on the microstructure and mechanical properties of meniscus extracellular matrix-derived implants J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-03 Soraya Salinas-Fernandez, Orquidea Garcia, Daniel J. Kelly, Conor T. Buckley
Meniscus-related injuries are a common orthopedic challenge with an increasing incidence in the population. While the preservation of viable meniscal tissue is the preferred approach in repair strategies, complex or total traumatic lesions may require alternative therapeutic approaches such as meniscal reconstruction using allografts or engineered equivalents. Although clinical studies suggest promising
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Effect of collagen denaturation degree on mechanical properties and biological activity of nanofibrous scaffolds J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-03 Timur Kh Tenchurin, Elena V. Sytina, Elena V. Solovieva, Aleksey D. Shepelev, Vissarion G. Mamagulashvili, Sergey V. Krasheninnikov, Evgeniy V. Yastremskiy, Elizaveta V. Nesterenko, Aleksandr I. Buzin, Elena V. Istranova, Leonid P. Istranov, Timur Kh Fatkhudinov, Andrey A. Panteleyev, Sergey N. Chvalun
Further progress in regenerative medicine and bioengineering highly depends on the development of 3D polymeric scaffolds with active biological properties. The most attention is paid to natural extracellular matrix components, primarily collagen. Herein, nonwoven nanofiber materials with various degrees of collagen denaturation and fiber diameters 250–500 nm were produced by electrospinning, stabilized
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Advances in cardiac tissue engineering and heart-on-a-chip J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-01 Jennifer Kieda, Amid Shakeri, Shira Landau, Erika Yan Wang, Yimu Zhao, Benjamin Fook Lai, Sargol Okhovatian, Ying Wang, Richard Jiang, Milica Radisic
Recent advances in both cardiac tissue engineering and hearts-on-a-chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelled. The elongated structure of cardiomyocytes requires tuning of substrate properties and application
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Advances in cardiac tissue engineering and heart-on-a-chip J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-01 Jennifer Kieda, Amid Shakeri, Shira Landau, Erika Yan Wang, Yimu Zhao, Benjamin Fook Lai, Sargol Okhovatian, Ying Wang, Richard Jiang, Milica Radisic
Recent advances in both cardiac tissue engineering and hearts-on-a-chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelled. The elongated structure of cardiomyocytes requires tuning of substrate properties and application
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Influence of titanium nanoscale surface roughness on fibrinogen and albumin protein adsorption kinetics and platelet responses J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-10-30 Ryan D. Boehm, Shelby A. Skoog, Daysi M. Diaz-Diestra, Peter L. Goering, Benita J. Dair
Biomaterials with nanoscale topography have been increasingly investigated for medical device applications to improve tissue–material interactions. This study assessed the impact of nanoengineered titanium surface domain sizes on early biological responses that can significantly affect tissue interactions. Nanostructured titanium coatings with distinct nanoscale surface roughness were deposited on
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Tackling catheter-associated urinary tract infections with next-generation antimicrobial technologies J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-10-26 Lina Duque-Sanchez, Yue Qu, Nicolas H. Voelcker, Helmut Thissen
Urinary catheters and other medical devices associated with the urinary tract such as stents are major contributors to nosocomial urinary tract infections (UTIs) as they provide an access path for pathogens to enter the bladder. Considering that catheter-associated urinary tract infections (CAUTIs) account for approximately 75% of UTIs and that UTIs represent the most common type of healthcare-associated
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Fabrication of alginate-based hydrogel microparticle via ruthenium-catalyzed photocrosslinking J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-10-25 Fariba Noori, Hamid Reza Ghaderi Jafarbeigloo, Mozhgan Jirehnezhadyan, Maryam Mohajer, Mehdi Khanmohammadi, Arash Goodarzi
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Oxide degradation precedes additively manufactured Ti-6Al-4V selective dissolution: An unsupervised machine learning correlation of impedance and dissolution compared to Ti-29Nb-21Zr J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-10-25 Michael A. Kurtz, Kazzandra Alaniz, Peter W. Kurtz, Audrey C. Wessinger, Aldo Moreno-Reyes, Jeremy L. Gilbert
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Surface immobilized α-1 acid glycoprotein and collagen VI modulate mouse macrophage polarization and reduce the foreign body capsule J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-10-25 Alex C. Chen, Winston Ciridon, Sharon Creason, Buddy D. Ratner
Macrophages are widely recognized in modulating the foreign body response, and the manner in which they do so largely depends on their activation state, often referred to as their polarization. This preliminary study demonstrates that surface immobilized α-1 acid glycoprotein (AGP), as well as collagen VI (Col6) in conjunction with AGP, can direct macrophages towards the M2 polarization state in vitro