
显示样式: 排序: IF: - GO 导出
-
Corrigendum: “In vivo integration of poly(ε‐ caprolactone)/gelatin nanofibrous nerve guide seeded with teeth derived stem cells for peripheral nerve regeneration” J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-12-31 Mohammad‐Hossein Beigi; Laleh Ghasemi‐Mobarakeh; Molamma P. Prabhakaran; Khadijeh Karbalaie; Hamid Azadeh; Seeram Ramakrishna; Hossein Baharvand; Mohammad‐Hossein Nasr‐Esfahani
[https://doi.org/10.1002/jbm.a.35119] Recently, a Pubpeer note has highlighted similarities between different images in two Figures of our paper entitled "In vivo integration of poly(e‐caprolactone)/gelatin nanofibrous nerve guide seeded with teeth derived stem cells for peripheral nerve regeneration" that was published with DOI: 10.1002/jbm.a.35119) Indeed, image duplications in microscopy images
-
Effect of manganese, zinc, and copper on the biological and osteogenic properties of mesoporous bioactive glass nanoparticles J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-12-01 Fabian Westhauser; Sebastian Wilkesmann; Qaisar Nawaz; Frederike Hohenbild; Felix Rehder; Merve Saur; Jörg Fellenberg; Arash Moghaddam; Muhammad S. Ali; Wolfgang Peukert; Aldo R. Boccaccini
Mesoporous bioactive glass nanoparticles (MBGNs) have demonstrated promising properties for the local delivery of therapeutically active ions with the aim to improve their osteogenic properties. Manganese (Mn), zinc (Zn), and copper (Cu) ions have already shown promising pro‐osteogenic properties. Therefore, the concentration‐dependent impact of MBGNs (composition in mol%: 70 SiO2, 30 CaO) and MBGNs
-
Interleukin‐4 repairs wear particle induced osteolysis by modulating macrophage polarization and bone turnover J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-12-19 Jukka Pajarinen; Tzuhua Lin; Akira Nabeshima; Taishi Sato; Emmanuel Gibon; Eemeli Jämsen; Tahsin N. Khan; Zhenyu Yao; Stuart B. Goodman
Periprosthetic osteolysis remains as a major complication of total joint replacement surgery. Modulation of macrophage polarization with interleukin‐4 (IL‐4) has emerged as an effective means to limit wear particle‐induced osteolysis. The aim of this study was to evaluate the efficacy of local IL‐4 delivery in treating preexisting particle‐induced osteolysis. To this end, recently established 8 week
-
Fluorine‐incorporated TiO2 nanotopography enhances adhesion and differentiation through ERK/CREB pathway J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-11-30 Hyang‐Seon Ro; Hee‐Jung Park; Young‐Kwon Seo
This study compared the topography of different titanium surface structures (TiO2 nanotube and grain) with similar elemental compositions (TiO2 and fluorine [F]) on the Ti surface. High magnification indicated that the surfaces of the control and etching groups were similar to each other in a flat, smooth form. The group anodized for 1 h was observed with TiO2 nanotubes organized very neatly and regularly
-
Effect of the immune responses induced by implants in a integrated three‐dimensional micro‐nano topography on osseointegration J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-11-30 Yun Yang; Ting Zhang; Mengyang Jiang; Xiaojie Yin; Xiayan Luo; Huiqiang Sun
In order to explore the abilities of an integrated three‐dimensional micro‐nano topography in immunomodulation and promoting bone formation, present study focuses on the titanium sheets used in the micro‐nano topography by treating them with the sandblasted, large‐grit and acid‐etched (SLA)and alkaline thermal reaction. Further, we characterized and obtained the surface morphology, roughness, and hydrophilicity
-
Biocompatibility and biodegradability evaluation of magnesium‐based intramedullary bone implants in avian model J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-12-01 Abhishek M. S.; Satish Jaiswal; Anshu Dubey; Debrupa Lahiri; Arup Kumar Das
At present days osteosynthesis modalities for avian fracture management are inadequate. External coaptation is the most practiced method however, specialized clinics have started introducing intramedullary pinning, external skeletal fixation with tie‐in‐fixation for fracture immobilization. Magnesium (Mg) based biomaterials are trustable developments in the field of orthopedics compared to their permanent
-
Platelet microparticles load a repertory of miRNAs programmed to drive osteogenic phenotype J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-12-01 Marcel Rodrigues Ferreira; Willian Fernando Zambuzzi
-
Development of a dinutuximab delivery system using silk foams for GD2 targeted neuroblastoma cell death J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-11-30 Kimberly J. Ornell; Bill Chiu; Jeannine M. Coburn
Neuroblastoma is the most common extracranial solid tumor of childhood and is associated with poor survival in high risk patients. Recently, dinutuximab (DNX) has emerged as an effective immunotherapy to treat patients with high risk neuroblastoma. DNX works through the induction of cell lysis via complement‐dependent cytotoxicity (CDC) or antibody dependent cellular cytotoxicity (ADCC). However, one
-
Meloxicam encapsulated nanostructured colloidal self‐assembly for evaluating antitumor and anti‐inflammatory efficacy in 3D printed scaffolds J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-12-01 Nilesh Rarokar; Ravikumar C; Shailendra Gurav; Pramod Khedekar
Nanostructured colloidal self‐assembly (NCS) is one of the most promising drug delivery carriers in cancer treatment. The present research work aimed towards synthesizing meloxicam (MLX) loaded NCS for its improved circulation half‐life and increased cellular internalization. NCS was formulated using glyceryl monoolein, Pluronic® F127, and MLX. Quality by Design experiments with a quadratic model was
-
Fabrication of multilayered electrospun poly(lactic‐co‐glycolic acid)/polyvinyl pyrrolidone + poly(ethylene oxide) scaffolds and biocompatibility evaluation J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-12-02 Jiao Chen; Xuanze Li; Qin Liu; Ying Wu; Liping Shu; Zhixu He; Chuan Ye; Minxian Ma
Poly(lactic‐co‐glycolic acid)/polyvinyl pyrrolidone + poly(ethylene oxide) [PLGA/(PVP + PEO)] scaffolds with different polymer concentrations were fabricated using multilayered electrospinning, and their physicochemical properties and biocompatibility were examined to screen for scaffolds with excellent performance in tissue engineering (TE). PLGA solution (15% w/v) was used as the bottom solution
-
Human decellularized adipose matrix derived hydrogel assists mesenchymal stem cells delivery and accelerates chronic wound healing J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-11-30 Zhaoyang Chen; Bowen Zhang; Jun Shu; Haiyang Wang; Yudi Han; Quan Zeng; Youbai Chen; Jiafei Xi; Ran Tao; Xuetao Pei; Wen Yue; Yan Han
-
Polyvinyl alcohol and pectin blended films: Preparation, characterization, and mesenchymal stem cells attachment J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-11-30 Aliaksandr Kraskouski; Kseniya Hileuskaya; Viktoryia Kulikouskaya; Volha Kabanava; Vladimir Agabekov; Sergei Pinchuk; Irina Vasilevich; Igor Volotovski; Tatyana Kuznetsova; Vasilina Lapitskaya
The design of novel wound dressings for chronic wound treatment is still of great importance. One of the promising approaches is application of mesenchymal stem cells (MSCs), immobilized on a flexible polymer film, for healing. In this study, blended films based on polyvinyl alcohol (PVA) and pectin with different component ratio have been prepared by solution casting method and evaluated. Physicochemical
-
Preparation of a novel bovine cancellous bone/poly‐amino acid composite with low immunogenicity, proper strength, and cytocompatibility in vitro J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-12-01 Lin Luo; Shuyang Li; Mizhi Ji; Zhengwen Ding; Yonggang Yan; Jie Yin; Yi Xiong
In this work, the delipidized and deproteinized bovine cancellous bone powder/poly–amino acid (DDBP/PAA) composite was fabricated by extrusion‐injection molding method for the first time. After about 70% clearance rate by the delipidization and deproteinization procedures, the residual antigens of galactosyl α–(1, 3)–galactosyl β–1,4–N–aeetylglueosaminyl (α–Gal) and major histocompatibility complex
-
Corrigendum J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-01
Corrigendum: “Increased osteoblast functions among nanophase titania/poly(lactide‐co‐glycolide) composites of the highest nanometer surface roughness” Huinan Liu1 Elliott B. Slamovich1 Thomas J. Webster1 School of Materials Engineering 501 Northwestern Avenue, Purdue University West Lafayette Indiana 47907 [https://doi.org/10.1002/jbm.a.30734] For the paper Liu et al. J Biomed Mater Res 78(4): 798–807
-
Corrigendum: “Increased chondrocyte adhesion on nanotubular anodized titanium” J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-01
Kevin Burns1, Chang Yao1, Thomas J. Webster1. Division of Engineering and Department of Orthopedic Surgery, Brown University, Providence, Rhode Island 02912 [https://doi.org/10.1002/jbm.a.31899]. For the paper Burns et al. J. Biomed. Mater. Res. 88A: 561‐568. https://doi.org/10.1002/jbm.a.31899, we inadvertently failed to reference republishing of a subset of the panels and data from Figure 1(b) and
-
Corrigendum: Self‐assembled biomimetic Nano‐Matrix for stem cell anchorage J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-06
J Biomed Mater Res A. 2020;108(4):984–991. https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.36875. The authors would like to add a funding source to this published paper: NIH 5P30GM122732. We apologize for any inconvenience.
-
Corrigendum J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-07
Corrigendum: “Increased osteoblast adhesion on nanograined hydroxyapatite and tricalcium phosphate containing calcium titanate” Celaletdin Ergun1, Huinan Liu2, John W. Halloran3, Thomas J. Webster2 1. Mechanical Engineering Department, Istanbul Technical University, Taksim, 34,437 Istanbul, Turkey 2. Division of Engineering, Brown University, Providence, Rhode Island 02912 3. Materials Science and
-
Effect of bioactive Biosilicate®/F18 glass scaffolds on osteogenicdifferentiation of human adipose stem cells J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-18 Claudia P. Marin; Geovana L. Santana; Meghan Robinson; Stephanie M. Willerth; Murilo C. Crovace; Edgar D. Zanotto
This study evaluated the gene expression profile of the human adipose‐derived stem cells (hASCs) grown on the Biosilicate®/F18 glass (BioS‐2P/F18) scaffolds. hASCs were cultured using the osteogenic medium (control),the scaffolds, and their ionic extract. We observed that ALP activity was higher inhASCs grown on the BioS‐2P/F18 scaffolds than inhASCs cultured with the ionic extractor the osteogenic
-
In vitro osteogenic performance of two novel strontium and zinc‐containing glass polyalkenoate cements J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-30 Daniella Marx; Alireza Rahimnejad Yazdi; Marcello Papini; Mark Towler
Glass polyalkenoate cements (GPCs) are under investigation as potential bone adhesives, as they may provide an alternative to polymethylmethacrylate‐based cements. GPCs containing strontium (Sr) and zinc (Zn) in place of aluminium (Al) are of particular interest because these ions are known stimulators of osteoprogenitor differentiation. GPCs have been manufactured from a novel bioactive glass (SiO2:0
-
Tissue response to biphasic calcium phosphate covalently modified with either heparin or hyaluronic acid in a mouse subcutaneous implantation model J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-31 Sanja Stojanović; Hala AlKhoury; Milena Radenković; Vladimir Cvetković; Magdalena Jablonska; Christian E.H. Schmelzer; Frank Syrowatka; Jelena M. Živković; Thomas Groth; Stevo Najman
Biphasic calcium phosphate (BCP) materials are widely employed as bone substitute materials due to their resorption/degradation properties. Inflammation after implantation of such materials represents a prerequisite for bone tissue repair and regeneration but can be also problematic if it is not only transient and if it is followed by fibrosis and scarring. Here, we modified BCP covalently with hyaluronan
-
Fabrication and characterization of Ag‐ and Ga‐doped mesoporous glass‐coated scaffolds based on natural marine sponges with improved mechanical properties J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-21 Francesca E. Ciraldo; Marcela Arango‐Ospina; Wolfgang H. Goldmann; Ana M. Beltrán; Rainer Detsch; Alina Gruenewald; J. A. Roether; Aldo R. Boccaccini
Natural marine sponges were used as sacrificial template for the fabrication of bioactive glass‐based scaffolds. After sintering at 1050°C, the resulting samples were additionally coated with a silicate solution containing biologically active ions (Ag and Ga), well‐known for their antibacterial properties. The produced scaffolds were characterized by superior mechanical properties (maximum compressive
-
An in vitro assessment of the response of THP‐1 macrophages to varying stiffness of a glycol‐chitosan hydrogel for vocal fold tissue engineering applications J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-28 Patrick Thomas Coburn; Alexandre Camille Herbay; Mattia Berrini; Nicole Y. K. Li‐Jessen
The physical properties of a biomaterial play an essential role in regulating immune and reparative activities within the host tissue. This study aimed to evaluate the immunological impact of material stiffness of a glycol‐chitosan hydrogel designed for vocal fold tissue engineering. Hydrogel stiffness was varied via the concentration of glyoxal cross‐linker applied. Hydrogel mechanical properties
-
Inflammation and immunity gene expression profiling of macrophages on mineralized collagen J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-21 Chunxiu Meng; Kun Liu; Zhaoyong Lv; Yujue Zhang; Jun Li; Xin Luo; Huifen Qiang; Keyi Li; Fengzhen Liu; Bin Zhang; Fuzhai Cui
Mineralized collagen (MC) is a biomaterial that is commonly used in the treatment of bone defects. However, the inflammatory response after biomaterial implantation is a recurrent problem that requires urgent attention. Our previous studies on MC‐macrophage interactions were descriptive but we did not perform an in‐depth analysis on a genetic level to investigate the underlying mechanisms. In this
-
Is THP‐1 viability affected by the crystallinity of nanostructured carbonated hydroxyapatites? J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-13 Renata Moraes Lira; Suelen Cristina Sartoretto; Carolina da Silva Gouveia Pedrosa; Mônica Diuana Calasans‐Maia; Paulo Emílio Leite; José Mauro Granjeiro
In daily clinical practice, there is a notable variety of synthetic bone substitute, with various resorption rates, different chemical and structural characteristics that influence on bone regeneration and are not suitable for every clinical use. New biomaterials based on nanotechnology have been developed to be bioabsorbable as new bone is formed. This study intends to evaluate THP‐1 cell viability
-
Nucleic acid biohybrid nanocarriers with high‐therapeutic payload and controllable extended release of daunomycin for cancer therapy J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-13 Ricky Whitener; Robert J. Mosley; Jacek Wower; Mark Edward Byrne
We have developed a novel, nanosized drug carrier with high‐therapeutic payload, controllable release, and the potential for active tumor targeting. It consists of a 15 nm gold nanoparticle with dense surface loading of DNA duplexes. We utilize the natural intercalating behavior of daunomycin to load the drug between DNA base pairs. We obtained a high‐therapeutic payload of >1,000 drug molecules per
-
A three dimensional in vivo model of breast cancer using a thermosensitive chitosan‐based hydrogel and 4 T1 cell line in Balb/c J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-14 Leila Rezakhani; Morteza Alizadeh; Akram Alizadeh
The two‐dimensional (2D) models of breast cancer still exhibit a limited success. Whereas, three‐dimensional (3D) models provide more similar conditions to the tumor for growth of cancer cells. In this regard, a 3D in vivo model of breast cancer using 4 T1 cells and chitosan‐based thermosensitive hydrogel were designed. Chitosan/β‐glycerol phosphate hydrogel (Ch/β‐GP) was prepared with a final ratio
-
Corrigendum J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-23
Corrigendum: An understanding of enhanced osteoblast adhesion on various nanostructured polymeric and metallic materials prepared by ionic plasma deposition J Biomed Mater Res 92A: 1190–1,201, 2010, https://doi.org/10.1002/jbm.a.32433. Between the manuscripts Pareta et al., J Biomed Mater Res 92A: 1190–1,201, 2010, DOI: 10.1002/jbm.a.32433 and Pareta et al., Biotechnology and Bioengineering 103(3):
-
Characterization of chondroitinase‐induced lumbar intervertebral disc degenerationina sheep model intended for assessing biomaterials J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-11 Ryan Borem; Joshua Walters; Allison Madeline; Lee Madeline; Sanjitpal Gill; Jeremiah Easley; Jeremy Mercuri
Intervertebral disc (IVD) degeneration (IVDD) leads to structural and functional changes. Biomaterials for restoring IVD function and promoting regeneration are currently being investigated; however, such approaches require validation using animal models that recapitulate clinical, biochemical, and biomechanical hallmarks of the human pathology. Herein, we comprehensively characterized a sheep model
-
Corrigendum J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-21
Corrigendum: Increased osteoblast adhesion on nanoparticulate calcium phosphates with higher Ca/P ratios. Velasquez P, Luklinska ZB, Meseguer‐Olmo L, Mate‐Sanchez de Val JE, Delgado‐Ruiz RA, Calvo‐Guirado JL, Ramirez‐Fernandez MP, de Aza PN. αTCP ceramic doped with dicalcium silicate for bone regeneration applications prepared by powder metallurgy method: in vitro and in vivo studies. J Biomed Mater
-
Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-27 Eduardas Cicinskas; Maria A. Begun; Valeria V. Vikhareva; Yuri A. Karetin; Aleksandra A. Kalitnik
Ability of high molecular weight (HMW) κ‐ and λ‐carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7–20 and 10–170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment. We demonstrated that, with an
-
Comparison of insulin secretion by transduced adipose-derived and endometrial-derived stem cells in 2D and 3D cultures on fibrin scaffold. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-08-30 Roya Karimi,Zahra Barabadi,Bagher Larijani,Gholamreza Tavoosidana,Nasrin Lotfibakhshaiesh,Moloud Absalan,Zahra Jabbarpour,Seyed Naser Ostad,Jafar Ai
Type 1 diabetes is a metabolic disorder caused by the loss or dysfunction of β‐cells in the pancreas. Organ shortage is a critical concern of diabetic patients in need of beta islet transplantation. Tissue engineered islets are promising alternatives to traditional organ transplantation. Recent progress in stem cell biology and gene cloning techniques has raised hopes for the generation of insulin
-
Improvement of the mechanical and biological properties of bioactive glasses by the addition of zirconium oxide (ZrO2) as a synthetic bone graft substitute J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-03 Tae‐Yun Kang; Ji‐Young Seo; Jeong‐Hyun Ryu; Kwang‐Mahn Kim; Jae‐Sung Kwon
In this study, mechanical properties of bioactive glass (BAG) synthetic bone graft substitute was improved by containing ZrO2 (ZrO2‐BAG), while maintaining advantageous biological properties of BAG such as osteoinductive and osteoconductive properties. The ZrO2‐BAG was produced by adding ZrO2 in the following proportions to replace Na2O in 45S5 BAG: 1% (Zr1‐BAG), 3% (Zr3‐BAG), 6% (Zr6‐BAG), and 12%
-
The performance of 3D bioscaffolding based on a human periodontal ligament stem cell printing technique J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-05 Yinping Tian; Minyi Liu; Yaoyao Liu; Changzheng Shi; Yayu Wang; Tong Liu; Yi Huang; Peihua Zhong; Jian Dai; Xiangning Liu
Bone tissue plays an important role in supporting and protecting the structure and function of the human body. Bone defects are a common source of injury and there are many reconstruction challenges in clinical practice. However, 3D bioprinting of scaffolds provides a promising solution. Hydrogels have emerged as biomaterials with good biocompatibility and are now widely used as cell‐loaded materials
-
Localized hydrogel delivery of dendritic cells for attenuation of multiple sclerosis in a murine model J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-11 Aline M. Thomas; Nicholas M. Beskid; Jennifer L. Blanchfield; Aaron M. Rosado; Andrés J. García; Brian D. Evavold; Julia E. Babensee
In multiple sclerosis (MS), abnormally activated immune cells responsive to myelin proteins result in widespread damage throughout the central nervous system (CNS) and ultimately irreversible disability. Immunomodulation by delivering dendritic cells (DCs) utilizes a potent and rapid MS disease progression driver therapeutically. Here, we investigated delivering DCs for disease severity attenuation
-
Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-05 Sao Oe; Md. Abdul Masum; Osamu Ichii; Takanori Nishimura; Teppei Nakamura; Takashi Namba; Yuki Otani; Yasuhide Nakayama; Yaser Hosny Ali Elewa; Yasuhiro Kon
We investigated spatiotemporal changes in host tissues during foreign body reactions. Silicone tube was subcutaneously embedded into ICR mice, and tissue surrounding silicone (TSS) was observed at 2, 7, 14, 21, 28, 43, and 70 days (D) postsurgery. The thin layer (TL) and loose connective tissues (LCTs) (inside and outside the TSS) developed until D21 and densified afterward. Neutrophils infiltrated
-
Natural compounds from Leeamacrophyllaenhance phagocytosis and promote osteoblastsdifferentiationbyAlp, Type 1 collagen and Osteocalcin gene expression. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-28 Sayema Raiyan,Atiar Rahman,Abdullah Al Mamun,Muzammal Haque Asim,Arwa Makki,Dina Hajjar,Walla Alelwani,Jitbanjong Tangpong,Bijo Mathew
The current study investigated the immunomodulating and osteoblast differentiation potential of the natural compounds from Leea macrophylla (LMN). Immunomodulatory effects have been investigated by the phagocytosis of Candida albicans using polymorphonuclear neutrophil cells in the in vitro slide method. A bioactivity‐guided fractionation technique was used to evaluate the stimulating effect of L.
-
Retraction J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-15
Retraction: Velasquez P, Luklinska ZB, Meseguer‐Olmo L, Mate‐Sanchez de Val JE, Delgado‐Ruiz RA, Calvo‐Guirado JL, Ramirez‐Fernandez MP, de Aza PN. αTCP ceramic doped with dicalcium silicate for bone regeneration applications prepared by powder metallurgy method: in vitro and in vivo studies. J Biomed Mater Res. 101A: 1943–1954. https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.34495. The above
-
Retraction J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-10-15
Retraction: Maté‐Sánchez de Val JE, Calvo‐Guirado JL, Delgado‐Ruiz RA, Ramírez‐Fernández MP, Negri B, Abboud M, Martínez IM, de Aza PN. Physical properties, mechanical behavior, and electron microscopy study of a new α‐TCP block graft with silicon in an animal model. J. Biomed. Mater. Res., 100A: 3446–3454. https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.34259 The above article, published online
-
Tyrosine‐derived polycarbonate nerve guidance tubes elicit proregenerative extracellular matrix deposition when used to bridge segmental nerve defects in swine J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-28 Justin C. Burrell; Divya Bhatnagar; Dan P. Brown; N. Sanjeeva Murthy; John Dutton; Kevin D. Browne; Franco A. Laimo; Zarina S. Ali; Joseph M. Rosen; Hilton M. Kaplan; Joachim Kohn; D. Kacy Cullen
Promising biomaterials should be tested in appropriate large animal models that recapitulate human inflammatory and regenerative responses. Previous studies have shown tyrosine‐derived polycarbonates (TyrPC) are versatile biomaterials with a wide range of applications across multiple disciplines. The library of TyrPC has been well studied and consists of thousands of polymer compositions with tunable
-
Effects of beta‐tricalcium phosphate nanoparticles on the properties of a thermosensitive chitosan/collagen hydrogel and controlled release of quercetin J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-28 Maytha Sareethammanuwat; Supakorn Boonyuen; Premjit Arpornmaeklong
In the present study, an inorganic matrix of beta‐tricalcium phosphate (bTCP) nanoparticles and quercetin was incorporated into an organic matrix of 2:1 (w/w) chitosan/collagen composite to fabricate thermosensitive bTCP‐chitosan/collagen‐quercetin hydrogels. A sol–gel transition of the hydrogels was stimulated by beta‐glycerophosphate (bGP) and temperature changes at physiological temperature and
-
Skin wound healing assisted by angiogenic targeted tissue engineering: A comprehensive review of bioengineered approaches J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-27 Shirin Nour; Rana Imani; G. Rasul Chaudhry; Ali Mohammad Sharifi
-
Synthesis and characterization of poly(vinyl alcohol)/chondroitin sulfate composite hydrogels containing strontium‐doped hydroxyapatite as promising biomaterials J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-28 Guillermo Grazioli; Adriana F. Silva; Jaqueline F. Souza; Carla David; Lisiane Diehl; Manoel D. Sousa‐Neto; Sergio S. Cava; André R. Fajardo; Rafael R. Moraes
Novel poly(vinyl alcohol)/chondroitin sulfate (PVA/CS) composite hydrogels containing hydroxyapatite (HA) or Sr‐doped HA (HASr) particles were synthesized by a freeze/thaw method and characterized aiming towards biomedical applications. HA and HASr were synthesized by a wet‐precipitation method and added to the composite hydrogels in fractions up to 15 wt%. Physical–chemical characterizations of particles
-
Bone morphogenetic protein‐2 delivery from polyelectrolyte multilayers enhances osteogenic activity on nanostructured titania J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-28 Tara B. Wigmosta; Ketul C. Popat; Matt J. Kipper
Incomplete osseointegration is primary cause of failure for orthopedic implants. New biomaterials that present stable signals promoting osteogenesis could reduce failure rates of orthopedic implants. In this study bone morphogenetic protein‐2 (BMP‐2) was delivered from titania nanotubes (Nt) modified with chitosan/heparin polyelectrolyte multilayers (PEMs). The surfaces were characterized by scanning
-
Dexamethasone‐loaded β‐cyclodextrin for osteogenic induction of mesenchymal stem/progenitor cells and bone regeneration J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-27 Xing Li; Lu Xu; Hemin Nie; Lei Lei
Dexamethasone (DEX) is a glucocorticoid commonly used as an in vitro osteogenic inducer of mesenchymal stem/progenitor cells (abbreviated MSCs). However, several studies investigating the effects of glucocorticoids on bone regeneration through systemic injections have demonstrated negative impacts of the drugs at high concentration on the healing of hard tissues. These contrasting evidences suggest
-
The degradation behavior of calcium‐rich hydroxyapatite foams in vitro J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-08-09 Qinghao Zhang; Wenfu Wang; Eva Schmelzer; Jörg Gerlach; Changsheng Liu; Ian Nettleship
Hydroxyapatite (HA) is a well‐known regenerative biomaterial. However, the slow degradation rate of HA is still an obstacle in clinical applications. In this study, we concentrated on investigating the degradation behavior of the calcium‐rich HA foams, which had a demonstrated effect on blood differentiation in previous studies. The HA foams were processed by an emulsion method and were infiltrated
-
Low-intensity pulsed ultrasoundpromotes the formationof periodontal ligament stem cell sheets and ectopic periodontal tissue regeneration. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-22 Han Li,Jie Zhou,Mengyuan Zhu,Siqi Ying,Lingjie Li,Duanjing Chen,Jie Li,Jinlin Song
Human periodontal ligament stem cells (hPDLSCs) sheets play an important role in periodontal tissue engineering. Low‐intensity pulsed ultrasound (LIPUS) has been reported as an effective stimulus to regulate cell biological behavior. The present study aims to explore the potential of LIPUS to promote the formation and function of hPDLSC sheets (hPDLSCSs). Hematoxylin–eosin (H&E) staining, western blot
-
Evaluation of annealed titanium oxide nanotubes on titanium.From surface characterization to in vivo assays. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-22 AndreaGomez Sanchez,María R Katunar,Juan Ignacio Pastore,María Florencia Tano de la Hoz,Silvia Ceré
The entire route from anodic oxidation and surface characterization, including in vitro experiments and finally in vivo osseointegration assays were performed with the aim to evaluate nanotubular and crystalline annealed titanium oxides as a suitable surface for grade 2 titanium permanent implants. Polished titanium (T0) was compared with anodized surfaces obtained in acidic media with fluoride, leading
-
Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cellfates in 3D. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-08-30 Danqing Zhu,Pavin Trinh,Jianfeng Li,Gerry A Grant,Fan Yang
Brain cancer is a devastating disease given its extreme invasiveness and intricate location. Glioblastoma multiforme (GBM) is one of the most common forms of brain cancer, and cancer progression is often correlated with significantly altered tissue stiffness. To elucidate the effect of matrix stiffness on GBM cell fates, previous research is largely limited to 2D studies using immortalized cell lines
-
Sustained delivery of vascular endothelial growth factor from mesoporous calcium-deficient hydroxyapatite microparticles promotes in vitro angiogenesis and osteogenesis. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-12 Charlotte Piard,Rachel Luthcke,Timur Kamalitdinov,John Fisher
Promoting the growth of blood vessels within engineered tissues remains one of the main challenge in bone tissue engineering. One way to improve angiogenesis is the use of vascular endothelial growth factor (VEGF) as it holds the ability to increase the formation of a vascular network. In the present study, collagen scaffolds with VEGF‐releasing hydroxyapatite particles were fabricated, in order to
-
Advancing continuous subcutaneous insulin infusion in vivo: New insights into tissue challenges. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-08 Shereen Kesserwan,Adam Mulka,Roshanak Sharafieh,Yi Qiao,Rong Wu,Donald L Kreutzer,Ulrike Klueh
Continuous Subcutaneous Insulin Infusion (CSII) is superior to conventional insulin therapy as it improves glycemic control thus reducing the probability of diabetic complications. Notwithstanding CSII's benefits, insulin dependent diabetic patients rarely achieve optimal glucose control. Moreover, CSII is only FDA approved for 3 days and often fails prematurely for reasons that have not been fully
-
Versatile lysine dendrigrafts and polyethylene glycol hydrogels with inherent biological properties: in vitro cell behavior modulation and in vivo biocompatibility. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-08-10 Mariana Carrancá,Louise Griveau,Noëlle Remoué,Chloé Lorion,Pierre Weiss,Valérie Orea,Dominique Sigaudo-Roussel,Clément Faye,Daniel Ferri-Angulo,Romain Debret,Jérôme Sohier
Poly(ethylene glycol) (PEG) hydrogels have been extensively used as scaffolds for tissue engineering applications, owing to their biocompatibility, chemical versatility, and tunable mechanical properties. However, their bio‐inert properties require them to be associated with additional functional moieties to interact with cells. To circumvent this need, we propose here to reticulate PEG molecules with
-
Regeneration of the peripheral nerve via multifunctional electrospun scaffolds. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-08-28 Nazanin Ghane,Shahla Khalili,Saied Nouri Khorasani,Rasoul Esmaeely Neisiany,Oisik Das,Seeram Ramakrishna
Over the last two decades, electrospun scaffolds have proved to be advantageous in the field of nerve tissue regeneration by connecting the cavity among the proximal and distal nerve stumps growth cones and leading to functional recovery after injury. Multifunctional nanofibrous structure of these scaffolds provides enormous potential by combining the advantages of nano‐scale topography, and biological
-
miR-34a carried by adipocyte exosomes inhibits the polarization of M1 macrophages in mouse osteolysis model. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-08-17 Xu-Ren Gao,Jian Ge,Wei-Yi Li,Wang-Chen Zhou,Lei Xu,De-Qin Geng
After bone prosthesis replacement, M1‐type macrophage polarization can be induced by titanium (Ti) particles and produce inflammatory, leading to osteolysis. Adipocyte‐derived exosomes (ADEs) exert immune‐modulatory impact on the macrophage, while whether it can inhibit the macrophage polarization induced by Ti is unclear. This study focuses on the M1‐type macrophage and aims to determine the effect
-
Cobalt-containing bioactive glass mimics vascular endothelial growth factor A and hypoxia inducible factor 1 function. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-09-02 Andréia Grossi Santos de Laia,Thalita Marcolan Valverde,Breno Rocha Barrioni,Pricila da Silva Cunha,Alfredo Miranda de Goes,Marcelo Coutinho de Miranda,Dawidson Assis Gomes,Celso Martins Queiroz-Junior,Marcos Augusto de Sá,Marivalda de Magalhães Pereira
-
Apatite matrix substituted with biologically essential rare earth elements as an artificial hard tissue substitute: Systematic physicochemical and biological evaluation J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-07-30 Likha Chandran; Ballamurugan AM
-
Immunomodulatory property and its regulatory mechanism of double network hydrogel on dendritic cells. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-08-28 Fujun Zhu,Yalin Tong,Yao Wu,Ning Dong,Zhiyong Sheng,Yongming Yao
Modulation of the key immune cell subsets by biomaterial has emerged as a potential target to promote tissue repair and regeneration. Based on calcium alginate (Alg) and glycol chitosan (GC), an injectable double‐network (DN) hydrogel has been developed as a scaffold for cell delivery and cell cocultured system. Previous studies have documented the interaction between dendritic cells (DCs) and GC or
-
GSVA score reveals molecular signatures from transcriptomes for biomaterials comparison. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-08-20 Marcel R Ferreira,Gerson A Santos,Carlos A Biagi,Wilson A Silva Junior,Willian F Zambuzzi
-
Design and fabrication of bone tissue scaffolds based on PCL/PHBV containing hydroxyapatite nanoparticles: dual‐leaching technique J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-08-17 Amir Nahanmoghadam; Maryam Asemani; Vahabodin Goodarzi; Somayeh Ebrahimi‐Barough
Scaffolds are the important part of the tissue‐engineering field that are made from different biomaterials using various techniques. In this study, new scaffold based on polycaprolactone (PCL) and poly (hydroxybutyrate‐co‐hydroxyvalerate) (PHBV) containing hydroxyapatite nanopraticles (n‐HA) were fabricated using the dual‐leaching technique (DLT). Morphology, porosity, degradation rate, Fourier transfer
-
Advances and trends of hydrogel therapy platform in localized tumor treatment: A review. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-07-18 Bowen Tan,Lingxiao Huang,Yongzhi Wu,Jinfeng Liao
Due to limitations of treatment and the stubbornness of infiltrative tumor cells, the outcome of conventional antitumor treatment is often compromised by a variety of factors, including severe side effects, unexpected recurrence, and massive tissue loss during the treatment. Hydrogel‐based therapy is becoming a promising option of cancer treatment, because of its controllability, biocompatibility,
-
Niosome-encapsulated tobramycin reduced antibiotic resistance and enhanced antibacterial activity against multidrug-resistant clinical strains of Pseudomonas aeruginosa. J. Biomed. Mater. Res. Part A (IF 3.525) Pub Date : 2020-08-31 Mojtaba Hedayati Ch,Arefeh Abolhassani Targhi,Farzaneh Shamsi,Fatemeh Heidari,Zahra Salehi Moghadam,Amir Mirzaie,Reyhaneh Behdad,Maryam Moghtaderi,Iman Akbarzadeh
In the current study, niosome‐encapsulated tobramycin based on Span 60 and Tween 60 was synthesized and its biological efficacies including anti‐bacterial, anti‐efflux, and anti‐biofilm activities were investigated against multidrug resistant (MDR) clinical strains of Pseudomonas aeruginosa. The niosomal formulations were characterized using scanning electron microscopy, transmission electron microscopy