[https://doi.org/10.1002/jbm.a.35119] Recently, a Pubpeer note has highlighted similarities between different images in two Figures of our paper entitled "In vivo integration of poly(e‐caprolactone)/gelatin nanofibrous nerve guide seeded with teeth derived stem cells for peripheral nerve regeneration" that was published with DOI: 10.1002/jbm.a.35119) Indeed, image duplications in microscopy images

Mesoporous bioactive glass nanoparticles (MBGNs) have demonstrated promising properties for the local delivery of therapeutically active ions with the aim to improve their osteogenic properties. Manganese (Mn), zinc (Zn), and copper (Cu) ions have already shown promising pro‐osteogenic properties. Therefore, the concentration‐dependent impact of MBGNs (composition in mol%: 70 SiO2, 30 CaO) and MBGNs

Periprosthetic osteolysis remains as a major complication of total joint replacement surgery. Modulation of macrophage polarization with interleukin‐4 (IL‐4) has emerged as an effective means to limit wear particle‐induced osteolysis. The aim of this study was to evaluate the efficacy of local IL‐4 delivery in treating preexisting particle‐induced osteolysis. To this end, recently established 8 week

This study compared the topography of different titanium surface structures (TiO2 nanotube and grain) with similar elemental compositions (TiO2 and fluorine [F]) on the Ti surface. High magnification indicated that the surfaces of the control and etching groups were similar to each other in a flat, smooth form. The group anodized for 1 h was observed with TiO2 nanotubes organized very neatly and regularly

In order to explore the abilities of an integrated three‐dimensional micro‐nano topography in immunomodulation and promoting bone formation, present study focuses on the titanium sheets used in the micro‐nano topography by treating them with the sandblasted, large‐grit and acid‐etched (SLA)and alkaline thermal reaction. Further, we characterized and obtained the surface morphology, roughness, and hydrophilicity

At present days osteosynthesis modalities for avian fracture management are inadequate. External coaptation is the most practiced method however, specialized clinics have started introducing intramedullary pinning, external skeletal fixation with tie‐in‐fixation for fracture immobilization. Magnesium (Mg) based biomaterials are trustable developments in the field of orthopedics compared to their permanent

Neuroblastoma is the most common extracranial solid tumor of childhood and is associated with poor survival in high risk patients. Recently, dinutuximab (DNX) has emerged as an effective immunotherapy to treat patients with high risk neuroblastoma. DNX works through the induction of cell lysis via complement‐dependent cytotoxicity (CDC) or antibody dependent cellular cytotoxicity (ADCC). However, one

Nanostructured colloidal self‐assembly (NCS) is one of the most promising drug delivery carriers in cancer treatment. The present research work aimed towards synthesizing meloxicam (MLX) loaded NCS for its improved circulation half‐life and increased cellular internalization. NCS was formulated using glyceryl monoolein, Pluronic® F127, and MLX. Quality by Design experiments with a quadratic model was

Poly(lactic‐co‐glycolic acid)/polyvinyl pyrrolidone + poly(ethylene oxide) [PLGA/(PVP + PEO)] scaffolds with different polymer concentrations were fabricated using multilayered electrospinning, and their physicochemical properties and biocompatibility were examined to screen for scaffolds with excellent performance in tissue engineering (TE). PLGA solution (15% w/v) was used as the bottom solution

The design of novel wound dressings for chronic wound treatment is still of great importance. One of the promising approaches is application of mesenchymal stem cells (MSCs), immobilized on a flexible polymer film, for healing. In this study, blended films based on polyvinyl alcohol (PVA) and pectin with different component ratio have been prepared by solution casting method and evaluated. Physicochemical

In this work, the delipidized and deproteinized bovine cancellous bone powder/poly–amino acid (DDBP/PAA) composite was fabricated by extrusion‐injection molding method for the first time. After about 70% clearance rate by the delipidization and deproteinization procedures, the residual antigens of galactosyl α–(1, 3)–galactosyl β–1,4–N–aeetylglueosaminyl (α–Gal) and major histocompatibility complex

Corrigendum: “Increased osteoblast functions among nanophase titania/poly(lactide‐co‐glycolide) composites of the highest nanometer surface roughness” Huinan Liu1 Elliott B. Slamovich1 Thomas J. Webster1 School of Materials Engineering 501 Northwestern Avenue, Purdue University West Lafayette Indiana 47907 [https://doi.org/10.1002/jbm.a.30734] For the paper Liu et al. J Biomed Mater Res 78(4): 798–807

Kevin Burns1, Chang Yao1, Thomas J. Webster1. Division of Engineering and Department of Orthopedic Surgery, Brown University, Providence, Rhode Island 02912 [https://doi.org/10.1002/jbm.a.31899]. For the paper Burns et al. J. Biomed. Mater. Res. 88A: 561‐568. https://doi.org/10.1002/jbm.a.31899, we inadvertently failed to reference republishing of a subset of the panels and data from Figure 1(b) and

J Biomed Mater Res A. 2020;108(4):984–991. https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.36875. The authors would like to add a funding source to this published paper: NIH 5P30GM122732. We apologize for any inconvenience.

Corrigendum: “Increased osteoblast adhesion on nanograined hydroxyapatite and tricalcium phosphate containing calcium titanate” Celaletdin Ergun1, Huinan Liu2, John W. Halloran3, Thomas J. Webster2 1. Mechanical Engineering Department, Istanbul Technical University, Taksim, 34,437 Istanbul, Turkey 2. Division of Engineering, Brown University, Providence, Rhode Island 02912 3. Materials Science and

This study evaluated the gene expression profile of the human adipose‐derived stem cells (hASCs) grown on the Biosilicate®/F18 glass (BioS‐2P/F18) scaffolds. hASCs were cultured using the osteogenic medium (control),the scaffolds, and their ionic extract. We observed that ALP activity was higher inhASCs grown on the BioS‐2P/F18 scaffolds than inhASCs cultured with the ionic extractor the osteogenic

Glass polyalkenoate cements (GPCs) are under investigation as potential bone adhesives, as they may provide an alternative to polymethylmethacrylate‐based cements. GPCs containing strontium (Sr) and zinc (Zn) in place of aluminium (Al) are of particular interest because these ions are known stimulators of osteoprogenitor differentiation. GPCs have been manufactured from a novel bioactive glass (SiO2:0

Biphasic calcium phosphate (BCP) materials are widely employed as bone substitute materials due to their resorption/degradation properties. Inflammation after implantation of such materials represents a prerequisite for bone tissue repair and regeneration but can be also problematic if it is not only transient and if it is followed by fibrosis and scarring. Here, we modified BCP covalently with hyaluronan

Natural marine sponges were used as sacrificial template for the fabrication of bioactive glass‐based scaffolds. After sintering at 1050°C, the resulting samples were additionally coated with a silicate solution containing biologically active ions (Ag and Ga), well‐known for their antibacterial properties. The produced scaffolds were characterized by superior mechanical properties (maximum compressive

The physical properties of a biomaterial play an essential role in regulating immune and reparative activities within the host tissue. This study aimed to evaluate the immunological impact of material stiffness of a glycol‐chitosan hydrogel designed for vocal fold tissue engineering. Hydrogel stiffness was varied via the concentration of glyoxal cross‐linker applied. Hydrogel mechanical properties

Mineralized collagen (MC) is a biomaterial that is commonly used in the treatment of bone defects. However, the inflammatory response after biomaterial implantation is a recurrent problem that requires urgent attention. Our previous studies on MC‐macrophage interactions were descriptive but we did not perform an in‐depth analysis on a genetic level to investigate the underlying mechanisms. In this

In daily clinical practice, there is a notable variety of synthetic bone substitute, with various resorption rates, different chemical and structural characteristics that influence on bone regeneration and are not suitable for every clinical use. New biomaterials based on nanotechnology have been developed to be bioabsorbable as new bone is formed. This study intends to evaluate THP‐1 cell viability

We have developed a novel, nanosized drug carrier with high‐therapeutic payload, controllable release, and the potential for active tumor targeting. It consists of a 15 nm gold nanoparticle with dense surface loading of DNA duplexes. We utilize the natural intercalating behavior of daunomycin to load the drug between DNA base pairs. We obtained a high‐therapeutic payload of >1,000 drug molecules per

The two‐dimensional (2D) models of breast cancer still exhibit a limited success. Whereas, three‐dimensional (3D) models provide more similar conditions to the tumor for growth of cancer cells. In this regard, a 3D in vivo model of breast cancer using 4 T1 cells and chitosan‐based thermosensitive hydrogel were designed. Chitosan/β‐glycerol phosphate hydrogel (Ch/β‐GP) was prepared with a final ratio

Corrigendum: An understanding of enhanced osteoblast adhesion on various nanostructured polymeric and metallic materials prepared by ionic plasma deposition J Biomed Mater Res 92A: 1190–1,201, 2010, https://doi.org/10.1002/jbm.a.32433. Between the manuscripts Pareta et al., J Biomed Mater Res 92A: 1190–1,201, 2010, DOI: 10.1002/jbm.a.32433 and Pareta et al., Biotechnology and Bioengineering 103(3):

Intervertebral disc (IVD) degeneration (IVDD) leads to structural and functional changes. Biomaterials for restoring IVD function and promoting regeneration are currently being investigated; however, such approaches require validation using animal models that recapitulate clinical, biochemical, and biomechanical hallmarks of the human pathology. Herein, we comprehensively characterized a sheep model

Corrigendum: Increased osteoblast adhesion on nanoparticulate calcium phosphates with higher Ca/P ratios. Velasquez P, Luklinska ZB, Meseguer‐Olmo L, Mate‐Sanchez de Val JE, Delgado‐Ruiz RA, Calvo‐Guirado JL, Ramirez‐Fernandez MP, de Aza PN. αTCP ceramic doped with dicalcium silicate for bone regeneration applications prepared by powder metallurgy method: in vitro and in vivo studies. J Biomed Mater

Ability of high molecular weight (HMW) κ‐ and λ‐carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7–20 and 10–170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment. We demonstrated that, with an

Type 1 diabetes is a metabolic disorder caused by the loss or dysfunction of β‐cells in the pancreas. Organ shortage is a critical concern of diabetic patients in need of beta islet transplantation. Tissue engineered islets are promising alternatives to traditional organ transplantation. Recent progress in stem cell biology and gene cloning techniques has raised hopes for the generation of insulin

In this study, mechanical properties of bioactive glass (BAG) synthetic bone graft substitute was improved by containing ZrO2 (ZrO2‐BAG), while maintaining advantageous biological properties of BAG such as osteoinductive and osteoconductive properties. The ZrO2‐BAG was produced by adding ZrO2 in the following proportions to replace Na2O in 45S5 BAG: 1% (Zr1‐BAG), 3% (Zr3‐BAG), 6% (Zr6‐BAG), and 12%

Bone tissue plays an important role in supporting and protecting the structure and function of the human body. Bone defects are a common source of injury and there are many reconstruction challenges in clinical practice. However, 3D bioprinting of scaffolds provides a promising solution. Hydrogels have emerged as biomaterials with good biocompatibility and are now widely used as cell‐loaded materials

In multiple sclerosis (MS), abnormally activated immune cells responsive to myelin proteins result in widespread damage throughout the central nervous system (CNS) and ultimately irreversible disability. Immunomodulation by delivering dendritic cells (DCs) utilizes a potent and rapid MS disease progression driver therapeutically. Here, we investigated delivering DCs for disease severity attenuation

We investigated spatiotemporal changes in host tissues during foreign body reactions. Silicone tube was subcutaneously embedded into ICR mice, and tissue surrounding silicone (TSS) was observed at 2, 7, 14, 21, 28, 43, and 70 days (D) postsurgery. The thin layer (TL) and loose connective tissues (LCTs) (inside and outside the TSS) developed until D21 and densified afterward. Neutrophils infiltrated

The current study investigated the immunomodulating and osteoblast differentiation potential of the natural compounds from Leea macrophylla (LMN). Immunomodulatory effects have been investigated by the phagocytosis of Candida albicans using polymorphonuclear neutrophil cells in the in vitro slide method. A bioactivity‐guided fractionation technique was used to evaluate the stimulating effect of L.

Retraction: Velasquez P, Luklinska ZB, Meseguer‐Olmo L, Mate‐Sanchez de Val JE, Delgado‐Ruiz RA, Calvo‐Guirado JL, Ramirez‐Fernandez MP, de Aza PN. αTCP ceramic doped with dicalcium silicate for bone regeneration applications prepared by powder metallurgy method: in vitro and in vivo studies. J Biomed Mater Res. 101A: 1943–1954. https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.34495. The above

Retraction: Maté‐Sánchez de Val JE, Calvo‐Guirado JL, Delgado‐Ruiz RA, Ramírez‐Fernández MP, Negri B, Abboud M, Martínez IM, de Aza PN. Physical properties, mechanical behavior, and electron microscopy study of a new α‐TCP block graft with silicon in an animal model. J. Biomed. Mater. Res., 100A: 3446–3454. https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.34259 The above article, published online

Promising biomaterials should be tested in appropriate large animal models that recapitulate human inflammatory and regenerative responses. Previous studies have shown tyrosine‐derived polycarbonates (TyrPC) are versatile biomaterials with a wide range of applications across multiple disciplines. The library of TyrPC has been well studied and consists of thousands of polymer compositions with tunable

In the present study, an inorganic matrix of beta‐tricalcium phosphate (bTCP) nanoparticles and quercetin was incorporated into an organic matrix of 2:1 (w/w) chitosan/collagen composite to fabricate thermosensitive bTCP‐chitosan/collagen‐quercetin hydrogels. A sol–gel transition of the hydrogels was stimulated by beta‐glycerophosphate (bGP) and temperature changes at physiological temperature and

Novel poly(vinyl alcohol)/chondroitin sulfate (PVA/CS) composite hydrogels containing hydroxyapatite (HA) or Sr‐doped HA (HASr) particles were synthesized by a freeze/thaw method and characterized aiming towards biomedical applications. HA and HASr were synthesized by a wet‐precipitation method and added to the composite hydrogels in fractions up to 15 wt%. Physical–chemical characterizations of particles

Incomplete osseointegration is primary cause of failure for orthopedic implants. New biomaterials that present stable signals promoting osteogenesis could reduce failure rates of orthopedic implants. In this study bone morphogenetic protein‐2 (BMP‐2) was delivered from titania nanotubes (Nt) modified with chitosan/heparin polyelectrolyte multilayers (PEMs). The surfaces were characterized by scanning

Dexamethasone (DEX) is a glucocorticoid commonly used as an in vitro osteogenic inducer of mesenchymal stem/progenitor cells (abbreviated MSCs). However, several studies investigating the effects of glucocorticoids on bone regeneration through systemic injections have demonstrated negative impacts of the drugs at high concentration on the healing of hard tissues. These contrasting evidences suggest

Hydroxyapatite (HA) is a well‐known regenerative biomaterial. However, the slow degradation rate of HA is still an obstacle in clinical applications. In this study, we concentrated on investigating the degradation behavior of the calcium‐rich HA foams, which had a demonstrated effect on blood differentiation in previous studies. The HA foams were processed by an emulsion method and were infiltrated

Human periodontal ligament stem cells (hPDLSCs) sheets play an important role in periodontal tissue engineering. Low‐intensity pulsed ultrasound (LIPUS) has been reported as an effective stimulus to regulate cell biological behavior. The present study aims to explore the potential of LIPUS to promote the formation and function of hPDLSC sheets (hPDLSCSs). Hematoxylin–eosin (H&E) staining, western blot

The entire route from anodic oxidation and surface characterization, including in vitro experiments and finally in vivo osseointegration assays were performed with the aim to evaluate nanotubular and crystalline annealed titanium oxides as a suitable surface for grade 2 titanium permanent implants. Polished titanium (T0) was compared with anodized surfaces obtained in acidic media with fluoride, leading

Brain cancer is a devastating disease given its extreme invasiveness and intricate location. Glioblastoma multiforme (GBM) is one of the most common forms of brain cancer, and cancer progression is often correlated with significantly altered tissue stiffness. To elucidate the effect of matrix stiffness on GBM cell fates, previous research is largely limited to 2D studies using immortalized cell lines

Promoting the growth of blood vessels within engineered tissues remains one of the main challenge in bone tissue engineering. One way to improve angiogenesis is the use of vascular endothelial growth factor (VEGF) as it holds the ability to increase the formation of a vascular network. In the present study, collagen scaffolds with VEGF‐releasing hydroxyapatite particles were fabricated, in order to

Continuous Subcutaneous Insulin Infusion (CSII) is superior to conventional insulin therapy as it improves glycemic control thus reducing the probability of diabetic complications. Notwithstanding CSII's benefits, insulin dependent diabetic patients rarely achieve optimal glucose control. Moreover, CSII is only FDA approved for 3 days and often fails prematurely for reasons that have not been fully

Poly(ethylene glycol) (PEG) hydrogels have been extensively used as scaffolds for tissue engineering applications, owing to their biocompatibility, chemical versatility, and tunable mechanical properties. However, their bio‐inert properties require them to be associated with additional functional moieties to interact with cells. To circumvent this need, we propose here to reticulate PEG molecules with

Over the last two decades, electrospun scaffolds have proved to be advantageous in the field of nerve tissue regeneration by connecting the cavity among the proximal and distal nerve stumps growth cones and leading to functional recovery after injury. Multifunctional nanofibrous structure of these scaffolds provides enormous potential by combining the advantages of nano‐scale topography, and biological

After bone prosthesis replacement, M1‐type macrophage polarization can be induced by titanium (Ti) particles and produce inflammatory, leading to osteolysis. Adipocyte‐derived exosomes (ADEs) exert immune‐modulatory impact on the macrophage, while whether it can inhibit the macrophage polarization induced by Ti is unclear. This study focuses on the M1‐type macrophage and aims to determine the effect

Modulation of the key immune cell subsets by biomaterial has emerged as a potential target to promote tissue repair and regeneration. Based on calcium alginate (Alg) and glycol chitosan (GC), an injectable double‐network (DN) hydrogel has been developed as a scaffold for cell delivery and cell cocultured system. Previous studies have documented the interaction between dendritic cells (DCs) and GC or

Scaffolds are the important part of the tissue‐engineering field that are made from different biomaterials using various techniques. In this study, new scaffold based on polycaprolactone (PCL) and poly (hydroxybutyrate‐co‐hydroxyvalerate) (PHBV) containing hydroxyapatite nanopraticles (n‐HA) were fabricated using the dual‐leaching technique (DLT). Morphology, porosity, degradation rate, Fourier transfer

Due to limitations of treatment and the stubbornness of infiltrative tumor cells, the outcome of conventional antitumor treatment is often compromised by a variety of factors, including severe side effects, unexpected recurrence, and massive tissue loss during the treatment. Hydrogel‐based therapy is becoming a promising option of cancer treatment, because of its controllability, biocompatibility,

In the current study, niosome‐encapsulated tobramycin based on Span 60 and Tween 60 was synthesized and its biological efficacies including anti‐bacterial, anti‐efflux, and anti‐biofilm activities were investigated against multidrug resistant (MDR) clinical strains of Pseudomonas aeruginosa. The niosomal formulations were characterized using scanning electron microscopy, transmission electron microscopy