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Fast-relaxing hydrogels with reversibly tunable mechanics for dynamic cancer cell culture Biomater. Adv. (IF 7.9) Pub Date : 2024-03-15 Yee Yee Khine, Han Nguyen, Favour Afolabi, Chien-Chi Lin
The mechanics of the tumor microenvironment (TME) significantly impact disease progression and the efficacy of anti-cancer therapeutics. While it is recognized that advanced in vitro cancer models will benefit cancer research, none of the current engineered extracellular matrices (ECM) adequately recapitulate the highly dynamic TME. Through integrating reversible boronate-ester bonding and dithiolane
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The importance of mechanical and biological cues of tympanic membrane grafts to ensure optimal regeneration Biomater. Adv. (IF 7.9) Pub Date : 2024-03-11 Oriana Nobus, Laurens Parmentier, Pieter Livens, Pieter Muyshondt, Krystyna Szewcyk, Christel Jacobs, Dorien Verdoodt, Leen Pieters, Quinten Thijssen, Bo Van Durme, Anne Vral, Joris Dirckx, Vincent Van Rompaey, Sandra Van Vlierberghe
Chronic suppurative otitis media (CSOM) is often associated with permanent tympanic membrane (TM) perforation and conductive hearing loss. The current clinical gold standard, using autografts and allografts, suffers from several drawbacks. Artificial replacement materials can help to overcome these drawbacks. Therefore, scaffolds fabricated through digital light processing (DLP) were herein created
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Angiogenesis in bone tissue engineering via ceramic scaffolds: A review of concepts and recent advancements Biomater. Adv. (IF 7.9) Pub Date : 2024-03-11 Farnoosh Abdollahi, Mahshid Saghatchi, Amirhosein Paryab, Adrine Malek Khachatourian, Emma D. Stephens, Muhammet S. Toprak, Maryam Badv
Due to organ donor shortages, long transplant waitlists, and the complications/limitations associated with auto and allotransplantation, biomaterials and tissue-engineered models are gaining attention as feasible alternatives for replacing and reconstructing damaged organs and tissues. Among various tissue engineering applications, bone tissue engineering has become a promising strategy to replace
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Hydrogels with dual sensitivity to temperature and pH in physiologically relevant ranges as supports for versatile controlled cell detachment Biomater. Adv. (IF 7.9) Pub Date : 2024-03-08 Rubén García-Sobrino, Irene Ruiz-Blas, Carolina García, Helmut Reinecke, Carlos Elvira, Juan Rodríguez-Hernández, Enrique Martínez-Campos, Alberto Gallardo
Thermosensitive hydrogels based on the -vinyl caprolactam (VCL), capable of allowing for cell adhesion and proliferation, as well as non-aggressive detachment by controlled temperature drop, were functionalized with 23 % or lower molar percentages of the cationizable hydrophobic unit 2-(diisopropylamino) ethyl methacrylate (DPAEMA), to obtain networks with dual sensitivity to temperature and pH. The
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Material matters: Degradation products affect regenerating Schwann cells Biomater. Adv. (IF 7.9) Pub Date : 2024-03-08 Kendell M. Pawelec, Jeremy M.L. Hix, Erik M. Shapiro
Devices to treat peripheral nerve injury (PNI) must balance many considerations to effectively guide regenerating nerves across a gap and achieve functional recovery. To enhance efficacy, design features like luminal fillers have been explored extensively. Material choice for PNI devices is also critical, as the determining factor of device mechanics, and degradation rate and has increasingly been
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Naturally sourced amphiphilic peptides as paclitaxel vehicles for breast cancer treatment Biomater. Adv. (IF 7.9) Pub Date : 2024-03-05 Rongli Chen, Ergang Liu, Yuefei Fang, Nan Gao, Meng Zhang, Xiaoru Zhang, Wanying Chen, Chuxin Liang, Yu Zhang, Yongzhuo Huang
The marketed paclitaxel (PTX) formulation Taxol relies on the application of Cremophor EL as a solubilizer. The major drawback of Taxol is its hypersensitivity reactions and a pretreatment of anti-allergic drugs is a necessity. Therefore, developing an efficient and safe delivery vehicle is a solution to increase PTX treatment outcomes with minimal adverse effects. In this work, we prepared the amphiphilic
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Evaluating the photodynamic efficacy of nebulized curcumin-loaded liposomes prepared by thin-film hydration and dual centrifugation: In vitro and in ovo studies Biomater. Adv. (IF 7.9) Pub Date : 2024-03-04 Lena Bender, Abdallah M. Ayoub, Jan Schulze, Muhammad Umair Amin, Damiano Librizzi, Konrad H. Engelhardt, Valeri Roschenko, Behrooz H. Yousefi, Jens Schäfer, Eduard Preis, Udo Bakowsky
Lung cancer, one of the most common causes of high mortality worldwide, still lacks appropriate and convenient treatment options. Photodynamic therapy (PDT) has shown promising results against cancer, especially in recent years. However, pulmonary drug delivery of the predominantly hydrophobic photosensitizers still represents a significant obstacle. Nebulizing DPPC/Cholesterol liposomes loaded with
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In vitro development and optimization of cell-laden injectable bioprinted gelatin methacryloyl (GelMA) microgels mineralized on the nanoscale Biomater. Adv. (IF 7.9) Pub Date : 2024-03-02 Mauricio Gonçalves da Costa Sousa, Gabriela de Souza Balbinot, Ramesh Subbiah, Rahul Madathiparambil Visalakshan, Anthony Tahayeri, Maria Elisa Lima Verde, Avathamsa Athirasala, Genevieve Romanowicz, Robert E. Guldberg, Luiz E. Bertassoni
Bone defects may occur in different sizes and shapes due to trauma, infections, and cancer resection. Autografts are still considered the primary treatment choice for bone regeneration. However, they are hard to source and often create donor-site morbidity. Injectable microgels have attracted much attention in tissue engineering and regenerative medicine due to their ability to replace inert implants
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Unlocking apoptosis in triple negative breast cancer: Harnessing “glutamine trap” to amplify the efficacy of lapatinib-loaded mixed micelles Biomater. Adv. (IF 7.9) Pub Date : 2024-03-02 Rohan Ghadi, Kaushik Kuche, Tushar Date, Bhargavi Nallamothu, Dasharath Chaudhari, Sanyog Jain
Certain aggressive cancers, such as triple-negative breast cancer (TNBC), heavily bank on glutamine for their proliferation and survival. In this context, TNBC functions as a “glutamine trap,” extracting circulating glutamine at a rate surpassing that of any other organ. Moreover, the overexpression of Alanine, Serine, Cysteine Transporter 2 (ASCT2), a key player in glutamine uptake, further underscores
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Development of novel hybrid 3D-printed degradable artificial joints incorporating electrospun pharmaceutical- and growth factor-loaded nanofibers for small joint reconstruction Biomater. Adv. (IF 7.9) Pub Date : 2024-02-28 Yung-Heng Hsu, Ying-Chao Chou, Chao-Lin Chen, Yi-Hsun Yu, Chia-Jung Lu, Shih-Jung Liu
Small joint reconstruction remains challenging and can lead to prosthesis-related complications, mainly due to the suboptimal performance of the silicone materials used and adverse host reactions. In this study, we developed hybrid artificial joints using three-dimensional printing (3D printing) for polycaprolactone (PCL) and incorporated electrospun nanofibers loaded with drugs and biomolecules for
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Functional nanomaterials as photosensitizers or delivery systems for antibacterial photodynamic therapy Biomater. Adv. (IF 7.9) Pub Date : 2024-02-28 Ruijiao Yan, Meijun Zhan, Jingchen Xu, Qiang Peng
Bacterial infection is a global health problem that closely related to various diseases threatening human life. Although antibiotic therapy has been the mainstream treatment method for various bacterial infectious diseases for decades, the increasing emergence of bacterial drug resistance has brought enormous challenges to the application of antibiotics. Therefore, developing novel antibacterial strategies
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Hyaluronic acid-based hydrogels with tunable mechanics improved structural and contractile properties of cells Biomater. Adv. (IF 7.9) Pub Date : 2024-02-28 Šimon Klimovič, Deborah Beckerová, Jakub Věžník, Daniil Kabanov, Karel Lacina, Sarka Jelinkova, Jaromír Gumulec, Vladimír Rotrekl, Jan Přibyl
Extracellular matrix (ECM) regulates cellular responses through mechanotransduction. The standard approach of in vitro culturing on plastic surfaces overlooks this phenomenon, so there is a need for biocompatible materials that exhibit adjustable mechanical and structural properties, promote cell adhesion and proliferation at low cost and for use in 2D or 3D cell cultures. This study presents a new
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Biodegradable and 3D printable lysine functionalized polycaprolactone scaffolds for tissue engineering applications Biomater. Adv. (IF 7.9) Pub Date : 2024-02-28 Sonali S. Naik, Arun Torris, Namita R. Choudhury, Naba K. Dutta, Kiran Sukumaran Nair
Tissue engineering (TE) has sparked interest in creating scaffolds with customizable properties and functional bioactive sites. However, due to limitations in medical practices and manufacturing technologies, it is challenging to replicate complex porous frameworks with appropriate architectures and bioactivity in vitro. To address these challenges, herein, we present a green approach that involves
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Ionized jet deposition of silver nanostructured coatings: Assessment of chemico-physical and biological behavior for application in orthopedics Biomater. Adv. (IF 7.9) Pub Date : 2024-02-25 Gabriela Graziani, Daniele Ghezzi, Marco Boi, Nicola Baldini, Enrico Sassoni, Martina Cappelletti, Giorgio Fedrizzi, Melania Maglio, Francesca Salamanna, Matilde Tschon, Lucia Martini, Stefano Zaffagnini, Milena Fini, Maria Sartori
Infection is one of the main issues connected to implantation of biomedical devices and represents a very difficult issue to tackle, for clinicians and for patients. This study aimed at tackling infection through antibacterial nanostructured silver coatings manufactured by Ionized Jet Deposition (IJD) for application as new and advanced coating systems for medical devices. Films composition and morphology
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Enhancing neuroinduction activity of PLCL-based nerve conduits through native epineurium integration Biomater. Adv. (IF 7.9) Pub Date : 2024-02-23 Xiao Li, Xiaoyan Mao, Meihan Tao, Fang Liang, Xiaohong Tian, Jun Fan, Xiaohong Wang, Tianhao Yu, Qiang Ao
Autologous nerve grafts have been considered the gold standard for peripheral nerve grafts. However, due to drawbacks such as functional loss in the donor area and a shortage of donor sources, nerve conduits are increasingly being considered as an alternative approach. Polymer materials have been widely studied as nerve repair materials due to their excellent processing performance. However, their
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Dual cross-linked COL1/HAp bionic gradient scaffolds containing human amniotic mesenchymal stem cells promote rotator cuff tendon–bone interface healing Biomater. Adv. (IF 7.9) Pub Date : 2024-02-09 Xiaomei Dai, Meijuan Yuan, Yuxia Yang, Mengbo Dang, Jian Yang, Junli Shi, Dianwei Liu, Mingjun Li, Hang Yao, Wenyong Fei
The tendon-bone interface heals through scar tissue, while the lack of a natural interface gradient structure and collagen fibre alignment leads to the occurrence of retearing. Therefore, the promotion of tendon healing has become the focus of regenerative medicine. The purpose of this study was to develop a gradient COL1/ hydroxyapatite (HAp) biomaterial loaded with human amniotic mesenchymal stem
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Corrigendum to “Additive manufacturing of Ni-free Ti-based shape memory alloys: A review” [Biomater. Adv. Volume 158 (2024) 213774] Biomater. Adv. (IF 7.9) Pub Date : 2024-02-06 Tania Vilella, Daniel Rodríguez, Gemma Fargas
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Corrigendum to “Modification of the small intestinal submucosa membrane with oligopeptides screened from intrinsically disordered regions to promote angiogenesis and accelerate wound healing” [Biomater. Adv. 148 (2023) 213360] Biomater. Adv. (IF 7.9) Pub Date : 2024-02-06 Shiqing Ma, Yilin Yang, Yuzhu Mu, Huizhen Peng, Pengfei Wei, Wei Jing, Cheng Peng, Xiangning Liu, Bo Zhao, Mingxiang Cai, Zihao Liu, Xueqiao Yu, Jiayin Deng
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Engineered platelet-based immune engager for tumor post-surgery treatment Biomater. Adv. (IF 7.9) Pub Date : 2024-02-03 Mo Chen, Jinniu Zhang, Huangjuan Li, Yueyang Deng, Yun Huang, Wenhao Shen, Yixing Zeng, Tianyuan Ci
Tumor metastasis and recurrence are principal reasons for the high mortality and poor prognosis of cancers. Inefficient engagement between T cell and tumor cell, as well as the universal existence of immune checkpoints, are important factors to the limited immunological surveillance of the immune systems to tumor cells. Herein, an immune engager based on engineered platelets with CD3 antibody modification
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Mechanistic insights into the spontaneous induction of bone formation Biomater. Adv. (IF 7.9) Pub Date : 2024-02-02 Ugo Ripamonti, Raquel Duarte
The grand discovery of morphogens, or “”, revealed that tissue morphogenesis is initiated by soluble molecular signals or morphogens primarily belonging to the transforming growth factor-β (TGF-β) supergene family. The regenerative potential of bone rests on its extracellular matrix, which is the repository of several morphogens that tightly control cellular differentiating pathways, cellular matrix
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Thermal spray processes influencing surface chemistry and in-vitro hemocompatibility of hydroxyapatite-based orthopedic implants Biomater. Adv. (IF 7.9) Pub Date : 2024-01-28 Deep Shankar, K. Jayaganesh, Niranjan Gowda, K.S. Lakshmi, K.J. Jayanthi, Sudhakar C. Jambagi
Orthopedic implants made from titanium are a popular choice in the medical field because of their remarkable strength-to-weight ratio. Nevertheless, they may not interact well with human blood, resulting in thrombosis and hemolysis. In fact, non-hemocompatibility is believed to be responsible for about 31 % of medical device failures in the US alone, requiring painful and expensive revision surgery
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3D printed barium titanate/calcium silicate composite biological scaffold combined with structural and material properties Biomater. Adv. (IF 7.9) Pub Date : 2024-01-26 Junnan Wu, Chen Jiao, Hanjiao Yu, Syed Mesum Raza Naqvi, Mengxing Ge, Kunzhan Cai, Huixin Liang, Jing Liu, Jianfeng Zhao, Zongjun Tian, Dongsheng Wang, Lida Shen
In the case of a large bone defect, the human endogenous electrical field is no longer sufficient. Therefore, it is necessary to support structural electrical bone scaffolds. Barium titanate (BT) has received much attention in bone tissue engineering applications due to its biocompatibility and ability to maintain charged surfaces. However, its processability is poor and it does not have the biological
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Polydopamine based photothermal/photodynamic synchronous coating modified intraocular lens for efficient and safer posterior capsule opacification prevention Biomater. Adv. (IF 7.9) Pub Date : 2024-01-24 Qiuna Fang, Chen Qin, Lan Duo, Fan Fei, Qingqing Jia, Hao Chen, Quankui Lin
Posterior capsule opacification (PCO), as one of the most common late complications after intraocular lens (IOL) implantation in cataract surgery, seriously affects patients' postoperative vision and surgical satisfaction, and can only be treated by laser incision of the posterior capsule. Although drug eluting coating modification have been proved to inhibit PCO effectively, the complicated coating
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In vitro cytotoxicity of magnetic-fluorescent bioactive glasses on SaOS-2, MC3T3-E1, BJ fibroblast cells, their hemolytic activity, and sorafenib release behavior Biomater. Adv. (IF 7.9) Pub Date : 2024-01-24 Aylin M. Deliormanlı, Begüm Rahman, Harika Atmaca
In the study, the fabrication of superparamagnetic-fluorescent bioactive glasses in the form of the particle, nanofiber, and 3D scaffolds was performed by including maghemite (γ-FeO) nanoparticles and photoluminescent rare earth element ions (Eu, Gd, and Yb) using sol-gel, electrospinning, and robocasting techniques, respectively. The cytotoxicity of the magnetic-fluorescent bioactive glasses on osteosarcoma
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Mechanical, bioactive, and long-lasting antibacterial properties of a Ti scaffold with gradient pores releasing iodine ions Biomater. Adv. (IF 7.9) Pub Date : 2024-01-24 Mahmoud Gallab, Phuc Thi Minh Le, Seine A. Shintani, Hiroaki Takadama, Morihiro Ito, Hisashi Kitagaki, Tomiharu Matsushita, Shintaro Honda, Yaichiro Okuzu, Shunsuke Fujibayashi, Seiji Yamaguchi
The ideal bone implant would effectively prevent aseptic as well as septic loosening by minimizing stress shielding, maximizing bone ingrowth, and preventing implant-associated infections. Here, a novel gradient-pore-size titanium scaffold was designed and manufactured to address these requirements. The scaffold features a larger pore size (900 μm) on the top surface, gradually decreasing to small
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A sustainable strategy for generating highly stable human skin equivalents based on fish collagen Biomater. Adv. (IF 7.9) Pub Date : 2024-01-24 Shi Hua Tan, Shaoqiong Liu, Swee Hin Teoh, Carine Bonnard, David Leavesley, Kun Liang
Tissue engineered skin equivalents are increasingly recognized as potential alternatives to traditional skin models such as human skin or animal skin models. However, most of the currently investigated human skin equivalents (HSEs) are constructed using mammalian collagen which can be expensive and difficult to extract. Fish skin is a waste product produced by fish processing industries and identified
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Hybrid gelatin-ascorbyl phosphate scaffolds accelerate diabetic wound healing via ROS scavenging, angiogenesis and collagen remodeling Biomater. Adv. (IF 7.9) Pub Date : 2024-01-21 Zhen Zhang, Chunlin Huang, Shiyao Guan, Liying Wang, Hanxiao Yin, Junqiang Yin, Jie Liu, Jun Wu
Skin wound healing, particularly diabetic wound healing, is challenging in clinical management. Impaired wound healing is associated with persistent oxidative stress, altered inflammatory responses, unsatisfactory angiogenesis and epithelialization. Magnesium ascorbyl phosphate (MAP), which is an ascorbic acid derivative and active ingredient in cosmetics, has been reported to scavenge , and is considered
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Gold nanoparticles decorated on MOF derived Cu5Zn8 hollow porous carbon nanocubes for magnetic resonance imaging guided tumor microenvironment-mediated synergistic chemodynamic and photothermal therapy Biomater. Adv. (IF 7.9) Pub Date : 2024-01-20 Senthilkumar Thirumurugan, Pranjyan Dash, Rajalakshmi Sakthivel, Yu-Chien Lin, Ying-Sui Sun, Ching-Po Lin, An-Ni Wang, Xinke Liu, Udesh Dhawan, Ren-Jei Chung
Combining chemodynamic therapy (CDT) with photothermal therapy (PTT) has developed as a promising approach for cancer treatment, as it enhances therapeutic efficiency through redox reactions and external laser induction. In this study, we designed metal organic framework (MOF) -derived CuZn/HPCNC through a carbonization process and decorated them with gold nanoparticles (Au@CuZn/HPCNC). The resulting
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Lab on chip based self-adjustable liposomes for rapid wound healing: An in depth in vitro, in vivo and higher dose toxicity investigation Biomater. Adv. (IF 7.9) Pub Date : 2024-01-19 Rahul Maheshwari, Piyush Ghode, Mayank Sharma
Thanks to microfluidic technology, different nano-delivery systems are becoming clinically viable. Using a novel and rapid microfluidic hydrodynamic focusing (MHF) method (lipids on chip) we developed self-adaptable liposomes (SLs) containing cefpodoxime proxetil (CP) for the treatment of skin infections caused by . SLs were optimized using different flow rate ratios in the MHF method and the final
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Zwitterion mediated anti-protein adsorption on polypropylene mesh to reduce inflammation for efficient hernia repair Biomater. Adv. (IF 7.9) Pub Date : 2024-01-19 Ying Mao, Qian Wang, Huiru Zhang, Yan Li, Lu Wang
The effectiveness of polypropylene (PP) mesh is often compromised by severe inflammation. Engineering anti-inflammatory coatings has significant implications for PP mesh to repair unwanted hernias. Here, we presented a facile strategy to develop an anti-fouling coating consisting of zwitterionic poly(carboxybetaine methacrylate) (PCBMA), which could prohibit protein adsorption to endow PP mesh with
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CD44 targeted-chondroitin sulfate nanoparticles: Fine-tuning hydrophobic groups to enhance in vitro pH-responsiveness and in vivo efficacy for advanced breast cancer treatment Biomater. Adv. (IF 7.9) Pub Date : 2024-01-18 Nayereh Azimijou, Reza Karimi-Soflou, Akbar Karkhaneh
The design of tumor-targeting nanoparticles with precisely controlled physical-biological properties may improve the delivery of chemotherapeutic agents. This study introduces pH-sensitive chondroitin sulfate-cholesterol (ChS-Chol) nano-assemblies for targeted intracellular doxorubicin (Dox) delivery in breast cancer treatment. Various ChS-Chol copolymers were synthesized, yielding self-assembling
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Optimizing the fabrication of electrospun nanofibers of prochlorperazine for enhanced dissolution and permeation properties Biomater. Adv. (IF 7.9) Pub Date : 2024-01-18 Hasham Shafi, D.V. Siva Reddy, Rumaisa Rashid, Trisha Roy, Shabnam Kawoosa, G.N. Bader, Chakradhar JVUS, Abdalla Abdal-hay, Mushtaq A. Beigh, Shafquat Majeed, Nisar Ahmad Khan, Faheem A. Sheikh
Despite being an approved antiemetic for more than five decades, the clinical usefulness of prochlorperazine is limited by its low solubility and inconsistent absorption in the gastrointestinal tract, which presents challenges for nanotherapeutic interventions. Here, we report the preparation of a highly soluble and permeable nanofiber formulation of prochlorperazine using the Quality-by-Design approach
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Biomaterial engineering for cell transplantation Biomater. Adv. (IF 7.9) Pub Date : 2024-01-17 Amirmasoud Samadi, Ali Moammeri, Shamim Azimi, Bexi M. Bustillo-Perez, M. Rezaa Mohammadi
The current paradigm of medicine is mostly designed to block or prevent pathological events. Once the disease-led tissue damage occurs, the limited endogenous regeneration may lead to depletion or loss of function for cells in the tissues. Cell therapy is rapidly evolving and influencing the field of medicine, where in some instances attempts to address cell loss in the body. Due to their biological
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Targeted pH- and redox-responsive AuS/micelles with low CMC for highly efficient sonodynamic therapy of metastatic breast cancer Biomater. Adv. (IF 7.9) Pub Date : 2024-01-17 Samane Maghsoudian, Hamidreza Motasadizadeh, Hassan Farhadnejad, Yousef Fatahi, Mohammad Hosein Fathian Nasab, Athar Mahdieh, Zeinab Nouri, Alyeh Abdollahi, Mohsen Amini, Fatemeh Atyabi, Rassoul Dinarvand
The efficacy of injectable micellar carriers is hindered due to the disassembly of micelles into free surfactants in the body, resulting in their dilution below the critical micelle concentration (CMC). Copolymer micelles were developed to address this issue, containing a superhydrophilic zwitterionic block and a superhydrophobic block with a disulfide bond, which exhibited a CMC lower than conventional
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Laminin mimetic angiogenic and collagen peptide hydrogel for enhance dermal wound healing Biomater. Adv. (IF 7.9) Pub Date : 2024-01-17 Meenakshi Saklani, Chandan B. Jha, Anurag T.K. Baidya, Sweta Singh, Rajnish Kumar, Rashi Mathur, Anjani K. Tiwari, Raunak Varshney
Laminins are essential in basement membrane architecture and critical in re-epithelialization and angiogenesis. These processes and collagen deposition are vital in skin wound healing. The role of angiogenic peptides in accelerating the wound-healing process has been known. The bioactive peptides could be a potential approach due to their similar effects as growth factors and inherent biocompatible
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Additive manufacturing of Ni-free Ti-based shape memory alloys: A review Biomater. Adv. (IF 7.9) Pub Date : 2024-01-15 Tània Vilella, Daniel Rodríguez, Gemma Fargas
Ni-free Ti-based Shape Memory Alloys composed of non-toxic elements have been studied as promising candidates for biomedical applications. However, high tool wear makes them complex to manufacture with conventional techniques. In this way, Additive Manufacturing technologies allow to fabricate complex three-dimensional structures overcoming their poor workability. Control of composition, porosity,
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Co-delivery of VEGF and amoxicillin using LP-coated co-axial electrospun fibres for the potential treatment of diabetic wounds Biomater. Adv. (IF 7.9) Pub Date : 2024-01-14 Robyn A. Macartney, Edward Weaver, Robyn Irwin, Matthew P. Wylie, George A. Burke, Dimitrios A. Lamprou
Diabetic complications present throughout a wide range of body tissues, however one of the most widely recognised complications remains to be chronic diabetic wounds. Current treatment options largely rely on standard wound treatment routines which provide no promotion of wound healing mechanisms at different physiological stages of repair. Recently materials produced using novel additive manufacturing
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3D bioprinted small extracellular vesicles from periodontal cells enhance mesenchymal stromal cell function Biomater. Adv. (IF 7.9) Pub Date : 2024-01-13 Pingping Han, Nimal Raveendran, Chun Liu, Saraswat Basu, Kexin Jiao, Nigel Johnson, Corey S. Moran, Sašo Ivanovski
Recent research indicates that combining 3D bioprinting and small extracellular vesicles (sEVs) offers a promising ‘cell-free’ regenerative medicine approach for various tissue engineering applications. Nonetheless, the majority of existing research has focused on bioprinting of sEVs sourced from cell lines. There remains a notable gap in research regarding the bioprinting of sEVs derived from primary
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Impact of surface biofunctionalization strategies on key effector cells response in polyacrylamide hydrogels for bone regeneration Biomater. Adv. (IF 7.9) Pub Date : 2024-01-13 Yi Zhang, Jinjun Dai, Ruiyue Hang, Xiaohong Yao, Long Bai, Di Huang, Ruiqiang Hang
Despite the clinical prevalence of various bone defect repair materials, a full understanding of their influence on bone repair and regeneration remains elusive. This study focuses on poly(acrylamide) (PAAm) hydrogels, popular 2D model substrates, which have regulable mechanical properties within physiological. However, their bio-inert nature requires surface biofunctionalization to enhance cell-material
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Nanotextured titanium inhibits bacterial activity and supports cell growth on 2D and 3D substrate: A co-culture study Biomater. Adv. (IF 7.9) Pub Date : 2024-01-12 Mohd I. Ishak, Rosalia Cuahtecontzi Delint, Xiayi Liu, Wei Xu, Penelope M. Tsimbouri, Angela H. Nobbs, Matthew J. Dalby, Bo Su
Medical implant-associated infections pose a significant challenge to modern medicine, with aseptic loosening and bacterial infiltration being the primary causes of implant failure. While nanostructured surfaces have demonstrated promising antibacterial properties, the translation of their efficacy from 2D to 3D substrates remains a challenge. Here, we used scalable alkaline etching to fabricate nanospike
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pH-responsive, self-sculptured Mg/PLGA composite microfibers for accelerated revascularization and soft tissue regeneration Biomater. Adv. (IF 7.9) Pub Date : 2024-01-11 Xianli Wang, Xiaoyu Li, Nannan Gu, Yi Shao, Yunfei Guo, Yongji Deng, Chenglin Chu, Feng Xue, Liqu Huang, Li Tao, Jing Bai
Biodegradable Mg/polymer composite fibers offer a promising therapeutic option for tissue injury because of bioactive Mg and biomimetic microstructure. However, current studies are limited to the contribution of Mg and the single microstructure. In this study, we designed Mg/poly (lactic--glycolic acid) (Mg/PLGA) composite microfibers that significantly enhanced angiogenesis and tissue regeneration
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Neutrophils-mediated bioinspired nanoagents for noninvasive monitoring of inflammatory recruitment dynamics and navigating phototherapy in rheumatoid arthritis Biomater. Adv. (IF 7.9) Pub Date : 2024-01-11 Hongchang Yu, Yanxian Wu, Jingwei Xu, Yangyun Wang, Xiaju Cheng, Leshuai W. Zhang, Jianzhong Qin, Yong Wang
Neutrophils play a crucial role in inflammatory immune responses, but their in vivo homing to inflammatory lesions remains unclear, hampering precise treatment options. In this study, we employed a biomineralization-inspired multimodal nanoagent to label neutrophils, enabling noninvasive monitoring of the dynamic process of inflammatory recruitment and guiding photothermal therapy in rheumatoid arthritis
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AgBiS2@CQDs/Ti nanocomposite coatings for combating implant-associated infections by photodynamic /photothermal therapy Biomater. Adv. (IF 7.9) Pub Date : 2024-01-11 Dongliang Huo, Ting Liu, Kangkang Huang, Changhui Que, Shuoyan Jiang, Yuxia Yang, Shaozao Tan, Langhuan Huang
Biofilm-mediated implant-associated infections are one of the most serious complications of implantation surgery, posing a grave threat to patient well-being. Effectively addressing bacterial infections is crucial for the success of implantation procedures. In this study, we prepared a bismuth sulfide silver@carbon quantum dot composite coating (AgBiS@CQDs/Ti) on a medical titanium surface by surface
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Co-release of nitric oxide and L-arginine from poly (β-amino ester)-based adhesive reprogram macrophages for accelerated wound healing and angiogenesis in vitro and in vivo Biomater. Adv. (IF 7.9) Pub Date : 2024-01-11 Parisa Heydari, Mahshid Kharaziha, Jaleh Varshosaz, Anousheh Zargar Kharazi, Shaghayegh Haghjooy Javanmard
Recently, insufficient angiogenesis and prolonged inflammation are crucial challenges of chronic skin wound healing. The sustained release of L-Arginine (L-Arg) and nitric oxide (NO) production can control immune responses, improve angiogenesis, enhance re-epithelialization, and accelerate wound healing. Here, we aim to improve wound healing the controlled release of NO and L-Arg from poly (β-amino
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Magnetically navigated microbubbles coated with albumin/polyarginine and superparamagnetic iron oxide nanoparticles Biomater. Adv. (IF 7.9) Pub Date : 2024-01-09 Olga I. Gusliakova, Maxim A. Kurochkin, Roman A. Barmin, Ekaterina S. Prikhozhdenko, Tatyana M. Estifeeva, Polina G. Rudakovskaya, Olga A. Sindeeva, Victor V. Galushka, Evgeny S. Vavaev, Aleksei S. Komlev, Evgeny V. Lyubin, Andrey A. Fedyanin, Krishna Kanti Dey, Dmitry A. Gorin
While microbubbles (MB) are routinely used for ultrasound (US) imaging, magnetic MB are increasingly explored as they can be guided to specific sites of interest by applied magnetic field gradient. This requires the MB shell composition tuning to prolong MB stability and provide functionalization capabilities with magnetic nanoparticles. Hence, we developed air-filled MB stabilized by a protein–polymer
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Amorphous magnesium phosphate-graphene oxide nano particles laden 3D-printed chitosan scaffolds with enhanced osteogenic potential and antibacterial properties Biomater. Adv. (IF 7.9) Pub Date : 2024-01-08 F. Pahlevanzadeh, R. Emadi, M. Kharaziha, S.A. Poursamar, F. Nejatidanesh, H. Emadi, R. Aslani, L. Moroni, M. Setayeshmehr
The utilization of 3D printing technology for the fabrication of graft substitutes in bone repair holds immense promise. However, meeting the requirements for printability, bioactivity, mechanical strength, and biological properties of 3D printed structures concurrently poses a significant challenge. In this study, we introduce a novel approach by incorporating amorphous magnesium phosphate-graphene
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Tailoring the pore design of embroidered structures by melt electrowriting to enhance the cell alignment in scaffold-based tendon reconstruction. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-26 Max von Witzleben,Judith Hahn,Ron F Richter,Bianca de Freitas,Emily Steyer,Kathleen Schütz,Corina Vater,Anne Bernhardt,Cindy Elschner,Michael Gelinsky
Tissue engineering of ligaments and tendons aims to reproduce the complex and hierarchical tissue structure while meeting the biomechanical and biological requirements. For the first time, the additive manufacturing methods of embroidery technology and melt electrowriting (MEW) were combined to mimic these properties closely. The mechanical benefits of embroidered structures were paired with a superficial
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MMP inhibition as a novel strategy for extracellular matrix preservation during whole liver decellularization. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-25 Mohammadreza Kasravi,Alireza Yaghoobi,Tahereh Tayebi,Mahsa Hojabri,Abdolkarim Talebi Taheri,Fatemeh Shirzad,Bahram Jambar Nooshin,Radman Mazloomnejad,Armin Ahmadi,Fatemeh A Tehrani,Ghasem Yazdanpanah,Mohammad Hadi Farjoo,Hassan Niknejad
As the only reliable treatment option for end-stage liver diseases, conventional liver transplantation confronts major supply limitations. Accordingly, the decellularization of discarded livers to produce bioscaffolds that support recellularization with progenitor/stem cells has emerged as a promising translational medicine approach. The success of this approach will substantially be determined by
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Antifibrotic properties of hyaluronic acid crosslinked polyisocyanide hydrogels. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-22 Jyoti Kumari,Roel Hammink,Jochem Baaij,Frank A D T G Wagener,Paul H J Kouwer
Fibrosis is characterized by the formation of fibrous connective tissue in response to primary injury. As a result, an affected organ may lose part of its functionality due to chronic, organ-specific tissue damage. Since fibrosis is a leading cause of death worldwide, targeting fibrotic diseases with antifibrotic hydrogels can be a lifesaving therapeutic strategy. This study developed a novel hybrid
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Comments on Rodrigues et al., "Investigation of plasma treatment on UHMWPE surfaces: Impact on physicochemical properties, sterilization and fibroblastic adhesion", Mater. Sci. Eng. C 102 (2019) 264-275, DOI: 10.1016/j.msec.2019.04.048. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-20 Dave Mangindaan,Daliansyah Danil,Rudy Purwondho,Suhenra Maulana,Olifia Rombot,Rida Zuraida
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Letter to editor - Reply to concerns on Rodrigues et al., "Investigation 1 of plasma treatment on UHMWPE surfaces: Impact on physicochemical properties, sterilization and fibroblastic adhesion", Mater. Sci. Eng. C 102 (2019) 264-275, DOI: 10.1016/j.msec.2019.04.048. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-17 Melissa Machado Rodrigues,Cristian Padilha Fontoura,Charlene Silvestrin Celi Garcia,Sandro Tomaz Martins,João Antonio Pêgas Henriques,Carlos Alejandro Figueroa,Mariana Roesch Ely,Cesar Aguzzoli
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Radial matrix constraint influences tissue contraction and promotes maturation of bi-layered skin equivalents. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-14 Jessica Polak,David Sachs,Nino Scherrer,Adrian Süess,Huan Liu,Mitchell Levesque,Sabine Werner,Edoardo Mazza,Gaetana Restivo,Mirko Meboldt,Costanza Giampietro
Human skin equivalents (HSEs) serve as important tools for mechanistic studies with human skin cells, drug discovery, pre-clinical applications in the field of tissue engineering and for skin transplantation on skin defects. Besides the cellular and extracellular matrix (ECM) components used for HSEs, physical constraints applied on the scaffold during HSEs maturation influence tissue organization
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In vivo investigation of boron-rich nanodrugs for treating triple-negative breast cancers via boron neutron capture therapy. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-13 Kai-Wei Lan,Wei-Yuan Huang,Yi-Lin Chiu,Fang-Tzu Hsu,Yun-Chen Chien,Yong-Yun Hsiau,Tzu-Wei Wang,Pei Yuin Keng
Triple-negative breast cancer (TNBC) is characterized by highly proliferative cancer cells and is the only subtype of breast cancer that lacks a targeted therapy. Boron neutron capture therapy (BNCT) is an approach that combines chemotherapy with radiotherapy and can potentially offer beneficial targeted treatment for TNBC patients owing to its unique ability to eradicate cancer cells selectively while
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Synthesis of bioactive hemoglobin-based oxygen carrier nanoparticles via metal-phenolic complexation. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-10 Mohammadsadegh Nadimifar,Weiguang Jin,Clara Coll-Satue,Gizem Bor,Paul Joseph Kempen,Ali Akbar Moosavi-Movahedi,Leticia Hosta-Rigau
The transfusion of donor red blood cells (RBCs) is seriously hampered by important drawbacks that include limited availability and portability, the requirement of being stored in refrigerated conditions, a short shelf life or the need for RBC group typing and crossmatching. Thus, hemoglobin (Hb)-based oxygen (O2) carriers (HBOCs) which make use of the main component of RBCs and the responsible protein
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Methods for improving the properties of zinc for the application of biodegradable vascular stents. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-07 Shiliang Chen,Tianming Du,Hanbing Zhang,Jing Qi,Yanping Zhang,Yongliang Mu,Aike Qiao
Biodegradable stents can support vessels for an extended period, maintain vascular patency, and progressively degrade once vascular remodeling is completed, thereby reducing the constraints of traditional metal stents. An ideal degradable stent must have good mechanical properties, degradation behavior, and biocompatibility. Zinc has become a new type of biodegradable metal after magnesium and iron
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A systematical review on antimicrobial peptides and their food applications. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-07 Kangjie Xu,XinYi Zhao,Yameng Tan,Junheng Wu,Yiqing Cai,Jingwen Zhou,Xinglong Wang
Food safety issues are a major concern in food processing and packaging industries. Food spoilage is caused by microbial contamination, where antimicrobial peptides (APs) provide solutions by eliminating microorganisms. APs such as nisin have been successfully and commonly used in food processing and preservation. Here, we discuss all aspects of the functionalization of APs in food applications. We
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Microfiber-reinforced hydrogels prolong the release of human induced pluripotent stem cell-derived extracellular vesicles to promote endothelial migration. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-07 Gerardo Cedillo-Servin,Ana Filipa Louro,Beatriz Gamelas,Ana Meliciano,Anne Zijl,Paula M Alves,Jos Malda,Margarida Serra,Miguel Castilho
Extracellular vesicle (EV)-based approaches for promoting angiogenesis have shown promising results. Yet, further development is needed in vehicles that prolong EV exposure to target organs. Here, we hypothesized that microfiber-reinforced gelatin methacryloyl (GelMA) hydrogels could serve as sustained delivery platforms for human induced pluripotent stem cell (hiPSC)-derived EV. EV with 50-200 nm
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GelMA-catechol coated FeHAp nanorods functionalized nanofibrous reinforced bio-instructive and mechanically robust composite hydrogel scaffold for bone tissue engineering. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-07 Zahid Hussain,Ismat Ullah,Xingzhu Liu,Shah Mehmood,Li Wang,Fanshu Ma,Salim Ullah,Zhongzhong Lu,Zixun Wang,Renjun Pei
Critical bone defects complicate tissue graft-based surgeries, raising healthcare expenditures and underscoring scaffold-based tissue-engineering strategies to support bone reconstruction. Our study highlighted that the phase-compatible combination of inorganic nanorods, nanofibers, and hydrogels is promising for developing biomimetic and cell-instructive scaffolds since the bone matrix is a porous
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Immobilized doxorubicin and ribociclib carbamate linkers encaged in surface modified cubosomes spatially target tumor reductive environment to enhance antitumor efficacy. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-04 Madhu Sharma,Dilip Panwar,Pratiksha Tiwari,Ankit Kumar,Shalini Gautam,Disha Marwaha,Nikhil Rai,Neha Singh,Avijit Kumar Bakshi,Neha Agarwal,Nisha Kumari C Singh,Kalyan Mitra,V M Prajapati,Prabhat Ranjan Mishra
In the present investigation, we have strategically synthesized Glutathione (GSH) stimuli-sensitive analogues using carbamate linkers (CL) of DOX (DOX-CL) and RB (RB-CL) which were then anchored to gold nanoparticles (Au-DOX-CL, Au-RB-CL) using mPEG as a spacer. It was observed that carbamate linkage (CL) with four carbon spacer is critical, to position the terminal thiol group, to access the carbamate
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In situ generated hemostatic adhesives: From mechanisms of action to recent advances and applications. Biomater. Adv. (IF 7.9) Pub Date : 2023-11-04 Luís P G Monteiro,João M M Rodrigues,João F Mano
Conventional surgical closure techniques, such as sutures, clips, or skin closure strips, may not always provide optimal wound closure and may require invasive procedures, which can result in potential post-surgical complications. As result, there is a growing demand for innovative solutions to achieve superior wound closure and improve patient outcomes. To overcome the abovementioned issues, in situ