A variety of bioinorganic ions have been reported to alter different cellular functions, including the transport of potassium (K+) and calcium (Ca2+) ions, while also modulating signal transduction, energy metabolism and cell proliferation due to the electro-potential change of the cell membrane. It was recently reported that the presence of such bivalent cations in the bone system is beneficial to

Understanding the surface interactions and reactivity of zinc (Zn)-based biomaterials with constituents of physiological fluids such as proteins and ions is essential for an accurate evaluation of biomaterial corrosion initiation and progression. In this paper, the effect of the albumin addition on the corrosion behavior of pure Zn and Zn–4Ag alloy is discussed. The corrosion behavior of Zn-based materials

Ideal hydrogels for tissue engineering applications should mimic the properties of native extracellular matrices and optimize the cell behavior. Silk fibroin (SF) that possesses tunable mechanical strength and low cytotoxicity and elastin protein that stimulates cell viability are complementary for hybrid hydrogels. Here, hydrolyzed elastin peptide (HEP) and reconstituted SF (RSF) are combined to generate

To understand the magnesium (Mg) degradation mechanism in vivo, a variety of in vitro investigations have been conducted. However, there is still a gap between in vitro results and in vivo observations. Herein, the combined effect of proteins and medium-flow conditions on magnesium degradation was studied. Bovine serum albumin (BSA) and fetal bovine serum (FBS) were employed as the commonly used protein

Silver nanoparticles (AgNP) are promising candidates for fighting drug-resistant infections because of their intrinsic antimicrobial effect. The design of high-yield antimicrobial molecules may inadvertently cause variation in host cells' biological responses. While many factors affect AgNPs' efficacy, their surface is exposed to the biological environment and thus plays a critical role in both the

Polyethylene glycol (PEG) coatings have been commonly used in reducing protein adsorption with the intent of improving a biomaterial's biocompatibility. To elucidate the role of PEG surface density in reducing protein adsorption, two types of grafted PEG surface density gradients were evaluated for the adsorption and desorption of albumin and fibrinogen, two blood proteins. PEG density gradients were