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Dual elemental doping activated signaling pathway of angiogenesis and defective heterojunction engineering for effective therapy of MRSA-infected wounds Bioact. Mater. (IF 18.9) Pub Date : 2024-03-14 Jin Huang, Shuilin Wu, Yi Wang, Jie Shen, Chaofeng Wang, Yufeng Zheng, Paul K. Chu, Xiangmei Liu
Multi-drug resistant bacterial infections pose a significant threat to human health. Thus, the development of effective bactericidal strategies is a pressing concern. In this study, a ternary heterostructure (Zn–CN/P-GO/BiS) comprised of Zn-doped graphite phase carbon nitride (g-CN), phosphorous-doped graphene oxide (GO) and bismuth sulphide (BiS) is constructed for efficiently treating methicillin-resistant
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Recent advances in carbon monoxide-releasing nanomaterials Bioact. Mater. (IF 18.9) Pub Date : 2024-03-14 Xiaomei Ning, Xinyuan Zhu, Youfu Wang, Jinghui Yang
As an endogenous signaling molecule, carbon monoxide (CO) has emerged as an increasingly promising option regarding as gas therapy due to its positive pharmacological effects in various diseases. Owing to the gaseous nature and potential toxicity, it is particularly important to modulate the CO release dosages and targeted locations to elucidate the biological mechanisms of CO and facilitate its clinical
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Thread-structural microneedles loaded with engineered exosomes for annulus fibrosus repair by regulating mitophagy recovery and extracellular matrix homeostasis Bioact. Mater. (IF 18.9) Pub Date : 2024-03-13 Shaojun Hu, Meng Zhu, Hongyuan Xing, Yucheng Xue, Jun Li, Zhan Wang, Zhou Zhu, Miaojie Fang, Zilong Li, Jianbin Xu, Yong He, Ning Zhang
Low back pain is among the most grave public health concerns worldwide and the major clinical manifestation of intervertebral disc degeneration (IVDD). The destruction of annulus fibrosus (AF) is the primary cause of IVDD. A sustainable and stable treatment system for IVDD is lacking because of the special organizational structure and low nutrient supply of AF. We here found that IVDD results in the
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Functional meniscus reconstruction with biological and biomechanical heterogeneities through topological self-induction of stem cells Bioact. Mater. (IF 18.9) Pub Date : 2024-03-11 Mingze Du, Kangze Liu, Huinan Lai, Jin Qian, Liya Ai, Jiying Zhang, Jun Yin, Dong Jiang
Meniscus injury is one of the most common sports injuries within the knee joint, which is also a crucial pathogenic factor for osteoarthritis (OA). The current meniscus substitution products are far from able to restore meniscal biofunctions due to the inability to reconstruct the gradient heterogeneity of natural meniscus from biological and biomechanical perspectives. Here, inspired by the topology
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Engineering customized nanovaccines for enhanced cancer immunotherapy Bioact. Mater. (IF 18.9) Pub Date : 2024-03-10 Jinyu Guo, Changhua Liu, Zhaoyang Qi, Ting Qiu, Jin Zhang, Huanghao Yang
Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines still encounter considerable challenges such as low delivery efficiency, limited targeting ability, and suboptimal efficacy. With an aim of addressing these issues, engineering customized nanovaccines through modification
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Enhanced osteochondral regeneration with a 3D-Printed biomimetic scaffold featuring a calcified interfacial layer Bioact. Mater. (IF 18.9) Pub Date : 2024-03-08 Di Wu, Kaiwen Zheng, Wenjing Yin, Bin Hu, Mingzhao Yu, Qingxiao Yu, Xiaojuan Wei, Jue Deng, Changqing Zhang
The integrative regeneration of both articular cartilage and subchondral bone remains an unmet clinical need due to the difficulties of mimicking spatial complexity in native osteochondral tissues for artificial implants. Layer-by-layer fabrication strategies, such as 3D printing, have emerged as a promising technology replicating the stratified zonal architecture and varying microstructures and mechanical
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Regulation of rheumatoid arthritis microenvironment via a self-healing injectable hydrogel for improved inflammation elimination and bone repair Bioact. Mater. (IF 18.9) Pub Date : 2024-03-08 Wenbo Geng, Jie Zhao, Bailong Tao, Yulu Yang, Qiaojian Duan, Pengfei Gao, Tingting He, Shaopeng Liu, Qian Feng, Peng Zhao, Kaiyong Cai
The rheumatoid arthritis (RA) microenvironment is often followed by a vicious circle of high inflammation, endogenous gas levels imbalance, and poor treatment. To break the circle, we develop a dual-gas-mediated injectable hydrogel for modulating the immune microenvironment of RA and simultaneously releasing therapeutic drugs. The hydrogel (DNRS gel) could be broken down on-demand by consuming excessive
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Feeder-free differentiation of human iPSCs into natural killer cells with cytotoxic potential against malignant brain rhabdoid tumor cells Bioact. Mater. (IF 18.9) Pub Date : 2024-03-08 Sonia Kiran, Yu Xue, Drishty B. Sarker, Yan Li, Qing-Xiang Amy Sang
Natural killer (NK) cells are cytotoxic immune cells that can eliminate target cells without prior stimulation. Human induced pluripotent stem cells (iPSCs) provide a robust source of NK cells for safe and effective cell-based immunotherapy against aggressive cancers. In this study, a feeder-free iPSC differentiation was performed to obtain iPSC-NK cells, and distinct maturational stages of iPSC-NK
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Self-adaptive pyroptosis-responsive nanoliposomes block pyroptosis in autoimmune inflammatory diseases Bioact. Mater. (IF 18.9) Pub Date : 2024-03-08 Kaiwang Xu, Huang Yang, Jinghua Fang, Kaijie Qiu, Haotian Shen, Guanrui Huang, Qiangqiang Zheng, Canlong Wang, Tengjing Xu, Xinning Yu, Jiajie Wang, Yunting Lin, Jiacheng Dai, Yuting Zhong, Hongyun Song, Sunan Zhu, Siheng Wang, Zhuxing Zhou, Guang Yang, Zhengwei Mao, Zongyou Pan, Xuesong Dai
Nanoliposomes have a broad range of applications in the treatment of autoimmune inflammatory diseases because of their ability to considerably enhance drug transport. For their clinical application, nanoliposomes must be able to realize on-demand release of drugs at disease sites to maximize drug-delivery efficacy and minimize side effects. Therefore, responsive drug-release strategies for inflammation
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Co-delivery of rhBMP-2 and zoledronic acid using calcium sulfate/hydroxyapatite carrier as a bioactive bone substitute to enhance and accelerate spinal fusion Bioact. Mater. (IF 18.9) Pub Date : 2024-03-06 Xinggui Tian, Corina Vater, Deepak Bushan Raina, Lisa Findeisen, Lucas-Maximilian Matuszewski, Magnus Tägil, Lars Lidgren, Anja Winkler, Robert Gottwald, Niels Modler, Klaus-Dieter Schaser, Alexander C. Disch, Stefan Zwingenberger
Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been FDA-approved for lumbar fusion, but supraphysiologic initial burst release due to suboptimal carrier and late excess bone resorption caused by osteoclast activation have limited its clinical usage. One strategy to mitigate the pro-osteoclast side effect of rhBMP-2 is to give systemic bisphosphonates, but it presents challenges with systemic
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Tumor-derived apoptotic extracellular vesicle-mediated intercellular communication promotes metastasis and stemness of lung adenocarcinoma Bioact. Mater. (IF 18.9) Pub Date : 2024-03-06 Xiaotian He, Yiyang Ma, Yingsheng Wen, Rusi Zhang, Dechang Zhao, Gongming Wang, Weidong Wang, Zirui Huang, Guangran Guo, Xuewen Zhang, Huayue Lin, Lanjun Zhang
Apoptosis has long been recognized as a significant mechanism for inhibiting tumor formation, and a plethora of stimuli can induce apoptosis during the progression and treatment of tumors. Moreover, tumor-derived apoptotic extracellular vesicles (apoEVs) are inevitably phagocytosed by live tumor cells, promoting tumor heterogeneity. Understanding the mechanism by which apoEVs regulate tumor cells is
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Robust reactive oxygen species modulator hitchhiking yeast microcapsules for colitis alleviation by trilogically intestinal microenvironment renovation Bioact. Mater. (IF 18.9) Pub Date : 2024-03-05 Jintao Li, Jian Song, Zhichao Deng, Jian Yang, Xiaoqin Wang, Bowen Gao, Yuanyuan Zhu, Mei Yang, Dingpei Long, Xiaoqin Luo, Mingxin Zhang, Mingzhen Zhang, Runqing Li
Ulcerative colitis (UC) is characterized by chronic inflammatory processes of the intestinal tract of unknown origin. Current treatments lack understanding on how to effectively alleviate oxidative stress, relieve inflammation, as well as modulate gut microbiota for maintaining intestinal homeostasis synchronously. In this study, a novel drug delivery system based on a metal polyphenol network (MPN)
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Engineering an extracellular matrix-functionalized, load-bearing tendon substitute for effective repair of large-to-massive tendon defects Bioact. Mater. (IF 18.9) Pub Date : 2024-03-05 Shuting Huang, Ying Rao, Meng Zhou, Anna M. Blocki, Xiao Chen, Chunyi Wen, Dai Fei Elmer Ker, Rocky S. Tuan, Dan Michelle Wang
A significant clinical challenge in large-to-massive rotator cuff tendon injuries is the need for sustaining high mechanical demands despite limited tissue regeneration, which often results in clinical repair failure with high retear rates and long-term functional deficiencies. To address this, an innovative tendon substitute named “BioTenoForce” is engineered, which uses (i) tendon extracellular matrix
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Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization Bioact. Mater. (IF 18.9) Pub Date : 2024-03-05 Hayeon Byun, Yujin Han, Eunhyung Kim, Indong Jun, Jinkyu Lee, Hyewoo Jeong, Seung Jae Huh, Jinmyoung Joo, Su Ryon Shin, Heungsoo Shin
Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization. Here, we propose a multi-functional composite hydrogel engineered to overcome such conditions through recruitment and activation of macrophages with adapted degradation of the hydrogel. The composite hydrogel (G-TSrP) is created by combining gelatin methacryloyl (GelMA) and nanoparticles
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Advanced PEG-tyramine biomaterial ink for precision engineering of perfusable and flexible small-diameter vascular constructs via coaxial printing Bioact. Mater. (IF 18.9) Pub Date : 2024-03-05 Julia Simińska-Stanny, Lise Nicolas, Adam Chafai, Hafez Jafari, Maryam Hajiabbas, Gianina Dodi, Ioannis Gardikiotis, Christine Delporte, Lei Nie, Daria Podstawczyk, Amin Shavandi
Vascularization is crucial for providing nutrients and oxygen to cells while removing waste. Despite advances in 3D-bioprinting, the fabrication of structures with void spaces and channels remains challenging. This study presents a novel approach to create robust yet flexible and permeable small (600–1300 μm) artificial vessels in a single processing step using 3D coaxial extrusion printing of a biomaterial
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A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy Bioact. Mater. (IF 18.9) Pub Date : 2024-03-05 Yu-jie Liu, Su-he Dong, Wen-hao Hu, Qiao-ling Chen, Shao-fu Zhang, Kai Song, Zhen-chuan Han, Meng-meng Li, Zhi-tao Han, Wei-bo Liu, Xue-song Zhang
Much effort has been devoted to improving treatment efficiency for osteosarcoma (OS). However, most current approaches result in poor therapeutic responses, thus indicating the need for the development of other therapeutic options. This study developed a multifunctional nanoparticle, PDA-MOF-E-M, an aggregation of OS targeting, programmed death targeting, and near-infrared (NIR)-aided targeting. At
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Apoptotic extracellular vesicles restore homeostasis of the articular microenvironment for the treatment of rheumatoid arthritis Bioact. Mater. (IF 18.9) Pub Date : 2024-03-04 Xian Li, Shichun Li, Xiaoling Fu, Yingjun Wang
Rheumatoid arthritis (RA) is a severe autoimmune disease with symptoms including synovial inflammation, cartilage erosion, and bone loss in RA lesions, which eventually lead to joint deformity and function loss. Most current treatments fail to achieve satisfying therapeutic outcomes with some adverse effects. Extracellular vesicles derived from apoptotic cells (apoEVs) have emerged as important mediators
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Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade Bioact. Mater. (IF 18.9) Pub Date : 2024-03-02 Saeid Moghassemi, Arezoo Dadashzadeh, Maria João Sousa, Hanne Vlieghe, Jie Yang, Cecibel María León-Félix, Christiani A. Amorim
Small extracellular vesicles (sEVs) are known to be secreted by a vast majority of cells. These sEVs, specifically exosomes, induce specific cell-to-cell interactions and can activate signaling pathways in recipient cells through fusion or interaction. These nanovesicles possess several desirable properties, making them ideal for regenerative medicine and nanomedicine applications. These properties
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Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis Bioact. Mater. (IF 18.9) Pub Date : 2024-03-01 Peng Hua, Ruifeng Liang, Suleixin Yang, Yanbei Tu, Meiwan Chen
Abnormal proliferation of aggressive fibroblast-like synoviocytes (FLS) and perpetuate synovial inflammation can inevitably accelerate the progression of rheumatoid arthritis (RA). Herein, a strategy of simultaneously promoting FLS apoptosis and inhibiting inflammation as mediated by macrophages is proposed to restore synovial homeostasis for effective RA therapy. A hyaluronic acid-based dissolvable
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Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment Bioact. Mater. (IF 18.9) Pub Date : 2024-03-01 Jiachao Xiong, Zhixiao Liu, Lingling Jia, Yulin Sun, Rong Guo, Tingting Xi, Zihan Li, Minjuan Wu, Hua Jiang, Yufei Li
Androgenic alopecia (AGA) is a highly prevalent form of non-scarring alopecia but lacks effective treatments. Stem cell exosomes have similar repair effects to stem cells, suffer from the drawbacks of high cost and low yield yet. Cell-derived nanovesicles acquired through mechanical extrusion exhibit favorable biomimetic properties similar to exosomes, enabling them to efficiently encapsulate substantial
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Combination of disulfiram and Copper−Cysteamine nanoparticles induces mitochondria damage and promotes apoptosis in endometrial cancer Bioact. Mater. (IF 18.9) Pub Date : 2024-03-01 Lijun Yang, Cancan Yao, Zhenning Su, Yihao Fang, Nil Kanatha Pandey, Eric Amador, Tian Diao, Guo Bao, Derong Cao, Xihua Chen, Xiangbo Xu, Bin He, Yufeng Zheng, Wei Chen
Endometrial cancer (EC) stands as one of the most prevalent gynecological malignancies affecting women, with its incidence and disease-related mortality steadily on the rise. Disulfiram (DSF), an FDA-approved medication primarily used for treating alcohol addiction, has exhibited promising anti-tumor properties. Studies have revealed DSF's capacity for enhanced anti-tumor activity, particularly when
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Controlled-release hydrogel loaded with magnesium-based nanoflowers synergize immunomodulation and cartilage regeneration in tendon-bone healing Bioact. Mater. (IF 18.9) Pub Date : 2024-02-28 Jintao Li, Haolin Ke, Xiangcheng Lei, Jiexin Zhang, Zhicheng Wen, Zhisheng Xiao, Huabin Chen, Juncheng Yao, Xuan Wang, Zhengnong Wei, Hongrui Zhang, Weilun Pan, Yan Shao, Yitao Zhao, Denghui Xie, Chun Zeng
Tendon-bone interface injuries pose a significant challenge in tissue regeneration, necessitating innovative approaches. Hydrogels with integrated supportive features and controlled release of therapeutic agents have emerged as promising candidates for the treatment of such injuries. In this study, we aimed to develop a temperature-sensitive composite hydrogel capable of providing sustained release
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Extracellular matrix stiffness as an energy metabolism regulator drives osteogenic differentiation in mesenchymal stem cells Bioact. Mater. (IF 18.9) Pub Date : 2024-02-28 Jing Na, Zhijie Yang, Qiusheng Shi, Chiyu Li, Yu Liu, Yaxin Song, Xinyang Li, Lisha Zheng, Yubo Fan
The biophysical factors of biomaterials such as their stiffness regulate stem cell differentiation. Energy metabolism has been revealed an essential role in stem cell lineage commitment. However, whether and how extracellular matrix (ECM) stiffness regulates energy metabolism to determine stem cell differentiation is less known. Here, the study reveals that stiff ECM promotes glycolysis, oxidative
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Tailoring therapeutics via a systematic beneficial elements comparison between photosynthetic bacteria-derived OMVs and extruded nanovesicles Bioact. Mater. (IF 18.9) Pub Date : 2024-02-26 Tingshan Xiao, Yichuan Ma, Ziyang Zhang, Yixin Zhang, Yu Zhao, Xiaohan Zhou, Xueyi Wang, Kun Ge, Junshu Guo, Jinchao Zhang, Zhenhua Li, Huifang Liu
Photosynthetic bacteria (PSB) has shown significant potential as a drug or drug delivery system owing to their photothermal capabilities and antioxidant properties. Nevertheless, the actualization of their potential is impeded by inherent constraints, including their considerable size, heightened immunogenicity and compromised biosafety. Conquering these obstacles and pursuing more effective solutions
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Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages Bioact. Mater. (IF 18.9) Pub Date : 2024-02-23 Fengbo Yang, Xiaoli Jia, Chao Hua, Feifan Zhou, Jianing Hua, Yuting Ji, Peng Zhao, Quan Yuan, Malcolm Xing, Guozhong Lyu
Nature makes the most beautiful solution to involuted problems. Among them, the parallel tubular structures are capable of transporting fluid quickly in plant trunks and leaf stems, which demonstrate an ingenious evolutionary design. This study develops a mini-thermoelectric semiconductor P–N module to create gradient and parallel channeled hydrogels. The modules decrease quickly the temperature of
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Axon-like aligned conductive CNT/GelMA hydrogel fibers combined with electrical stimulation for spinal cord injury recovery Bioact. Mater. (IF 18.9) Pub Date : 2024-02-22 Shenglian Yao, Yongdong Yang, Chenyu Li, Kaitan Yang, Xin Song, Chuanhong Li, Zheng Cao, He Zhao, Xing Yu, Xiumei Wang, Lu-Ning Wang
Rehabilitation and regenerative medicine are two promising approaches for spinal cord injury (SCI) recovery, but their combination has been limited. Conductive biomaterials could bridge regenerative scaffolds with electrical stimulation by inducing axon regeneration and supporting physiological electrical signal transmission. Here, we developed aligned conductive hydrogel fibers by incorporating carbon
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Fabrication of fully aligned self-assembled cell-laden collagen filaments for tissue engineering via a hybrid bioprinting process Bioact. Mater. (IF 18.9) Pub Date : 2024-02-21 JuYeon Kim, Hyeongjin Lee, Gyudo Lee, Dongryeol Ryu, GeunHyung Kim
Cell-laden structures play a pivotal role in various tissue engineering applications, particularly in tissue restoration. Interactions between cells within bioprinted structures are crucial for successful tissue development and regulation of stem cell fate through intricate cell-to-cell signaling pathways. In this study, we developed a new technique that combines polyethylene glycol (PEG)-infused submerged
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High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy Bioact. Mater. (IF 18.9) Pub Date : 2024-02-21 Decui Cheng, Rui Tian, Tingting Pan, Qiang Yu, Li Wei, Jiaozhi Liyin, Yunqi Dai, Xiaoli Wang, Ruoming Tan, Hongping Qu, Min Lu
Polymyxins are the last line of defense against multidrug-resistant (MDR) Gram-negative bacterial infections. However, this last resort has been threatened by the emergence of superbugs carrying the mobile colistin resistance gene-1 Given the high concentration of matrix metalloproteinase 3 (MMP-3) in bacterial pneumonia, limited plasma accumulation of colistin (CST) in the lung, and potential toxicity
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NIR-enhanced Pt single atom/g-C3N4 nanozymes as SOD/CAT mimics to rescue ATP energy crisis by regulating oxidative phosphorylation pathway for delaying osteoarthritis progression Bioact. Mater. (IF 18.9) Pub Date : 2024-02-21 Jianhui Xiang, Xin Yang, Manli Tan, Jianfeng Guo, Yuting Ye, Jiejia Deng, Zhangrui Huang, Hanjie Wang, Wei Su, Jianwen Cheng, Li Zheng, Sijia Liu, Jingping Zhong, Jinmin Zhao
Osteoarthritis (OA) progresses due to the excessive generation of reactive oxygen and nitrogen species (ROS/RNS) and abnormal ATP energy metabolism related to the oxidative phosphorylation pathway in the mitochondria. Highly active single-atom nanozymes (SAzymes) can help regulate the redox balance and have shown their potential in the treatment of inflammatory diseases. In this study, we innovatively
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Selenomethionine in gelatin methacryloyl hydrogels: Modulating ferroptosis to attenuate skin aging Bioact. Mater. (IF 18.9) Pub Date : 2024-02-20 Jiachen Sun, Xiaoye Xie, Yaoyao Song, Tianjun Sun, Xinzhu Liu, Huageng Yuan, Chuanan Shen
During skin aging, the degeneration of epidermal stem cells (EpiSCs) leads to diminished wound healing capabilities and epidermal disintegration. This study tackles this issue through a comprehensive analysis combining transcriptomics and untargeted metabolomics, revealing age-dependent alterations in the gene family and arachidonic acid (AA) metabolic networks, resulting in enhanced ferroptosis. Selenomethionine
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Urchin-like multiscale structured fluorinated hydroxyapatite as versatile filler for caries restoration dental resin composites Bioact. Mater. (IF 18.9) Pub Date : 2024-02-19 Shuning Zhang, Xiao Wang, Shi Yin, Junjun Wang, Hongyan Chen, Xinquan Jiang
Caries is one of the most prevalent human diseases, resulting from demineralization of tooth hard tissue caused by acids produced from bacteria, and can progress to pulpal inflammation. Filling restoration with dental resin composites (DRCs) is currently the most common treatment for caries. However, existing DRCs suffer from low fracture strength and lack comprehensive anti-caries bioactivity including
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Immunotherapy targeting the obese white adipose tissue microenvironment: Focus on non-communicable diseases Bioact. Mater. (IF 18.9) Pub Date : 2024-02-19 Lia Priscilla, Chaerim Yoo, Seonmi Jang, Sewon Park, Gayoung Lim, Taekyun Kim, Dong Yun Lee
Obesity triggers inflammatory responses in the microenvironment of white adipose tissue, resulting in chronic systemic inflammation and the subsequent development of non-communicable diseases, including type 2 diabetes, coronary heart disease, and breast cancer. Current therapy approaches for obesity-induced non-communicable diseases persist in prioritizing symptom remission while frequently overlooking
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Engineered M2 macrophage-derived extracellular vesicles with platelet membrane fusion for targeted therapy of atherosclerosis Bioact. Mater. (IF 18.9) Pub Date : 2024-02-17 Lan Xie, Jinyong Chen, Haochang Hu, Yuan Zhu, Xiying Wang, Siyu Zhou, Feifan Wang, Meixiang Xiang
Atherosclerosis is featured as chronic low-grade inflammation in the arteries, which leads to the formation of plaques rich in lipids. M2 macrophage-derived extracellular vesicles (MEV) have significant potential for anti-atherosclerotic therapy. However, their therapeutic effectiveness has been hindered by their limited targeting capability . The objective of this study was to create the P-MEV (platelet
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Type II collagen scaffolds repair critical-sized osteochondral defects under induced conditions of osteoarthritis in rat knee joints via inhibiting TGF-β-Smad1/5/8 signaling pathway Bioact. Mater. (IF 18.9) Pub Date : 2024-02-16 Xu Hu, Min Jin, Kang Sun, Zhen Zhang, Zhonglian Wu, Junli Shi, Peilai Liu, Hang Yao, Dong-An Wang
The bidirectional relationship between osteochondral defects (OCD) and osteoarthritis (OA), with each condition exacerbating the other, makes OCD regeneration in the presence of OA challenging. Type II collagen (Col2) is important in OCD regeneration and the management of OA, but its potential applications in cartilage tissue engineering are significantly limited. This study investigated the regeneration
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Corrigendum to “3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration” [Bioact. Mater. 31 (January 2024) 18–37] Bioact. Mater. (IF 18.9) Pub Date : 2024-02-16 Hao Huang, Lei Qiang, Minjie Fan, Yihao Liu, Anchun Yang, Dongbiao Chang, Jinsheng Li, Tong Sun, Yiwei Wang, Ruoyi Guo, Hanjie Zhuang, Xiangyu Li, Tailin Guo, Jinwu Wang, Huan Tan, Pengfei Zheng, Jie Weng
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Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor Bioact. Mater. (IF 18.9) Pub Date : 2024-02-16 Congyi Shen, Jian Wang, Guangfeng Li, Shuyue Hao, Yan Wu, Peiran Song, Yafei Han, Mengmeng Li, Guangchao Wang, Ke Xu, Hao Zhang, Xiaoxiang Ren, Yingying Jing, Ru Yang, Zhen Geng, Jiacan Su
Osteoarthritis (OA), a common degenerative disease, is characterized by high disability and imposes substantial economic impacts on individuals and society. Current clinical treatments remain inadequate for effectively managing OA. Organoids, miniature 3D tissue structures from directed differentiation of stem or progenitor cells, mimic native organ structures and functions. They are useful for drug
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Development of ovalbumin implants with different spatial configurations for treatment of peripheral nerve injury Bioact. Mater. (IF 18.9) Pub Date : 2024-02-15 Tiantian Zheng, Hongxia Gao, Yaqiong Liu, Shaolan Sun, Wenchao Guan, Linliang Wu, Yumin Yang, Guicai Li
Peripheral nerve injury (PNI) seriously affects the health and life of patients, and is an urgent clinical problem that needs to be resolved. Nerve implants prepared from various biomaterials have played a positive role in PNI, but the effect should be further improved and thus new biomaterials is urgently needed. Ovalbumin (OVA) contains a variety of bioactive components, low immunogenicity, tolerance
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Versatile dopamine-functionalized hyaluronic acid-recombinant human collagen hydrogel promoting diabetic wound healing via inflammation control and vascularization tissue regeneration Bioact. Mater. (IF 18.9) Pub Date : 2024-02-14 Yong Wang, Yuan Zhang, Yun-Peng Yang, Ming-Yuan Jin, Sha Huang, Ze-Ming Zhuang, Tao Zhang, Li-Li Cao, Xiao-Ying Lin, Jun Chen, Yong-Zhong Du, Jian Chen, Wei-Qiang Tan
The management of chronic wounds in diabetes remains challenging due to the complexity of impaired wound healing, delayed healing, susceptibility to infection, and elevated risk of reopening, highlighting the need for effective chronic wound management with innovative approaches such as multifunctional hydrogels. Here, we have produced HA-DA@rhCol hydrogels consisting of dopamine-modified hyaluronic
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A cigarette filter-derived biomimetic cardiac niche for myocardial infarction repair Bioact. Mater. (IF 18.9) Pub Date : 2024-02-14 Guofeng Tang, Zhentao Li, Chengbin Ding, Jiang Zhao, Xianglong Xing, Yan Sun, Xiaozhong Qiu, Leyu Wang
Cell implantation offers an appealing avenue for heart repair after myocardial infarction (MI). Nevertheless, the implanted cells are subjected to the aberrant myocardial niche, which inhibits cell survival and maturation, posing significant challenges to the ultimate therapeutic outcome. The functional cardiac patches (CPs) have been proved to construct an elastic conductive, antioxidative, and angiogenic
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Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation Bioact. Mater. (IF 18.9) Pub Date : 2024-02-14 Xin Liu, Xingyi Wan, Baiyan Sui, Quanhong Hu, Zhirong Liu, Tingting Ding, Jiao Zhao, Yuxiao Chen, Zhong Lin Wang, Linlin Li
The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration. Herein, we construct a piezoelectric hydrogel to rescue the impaired osteogenic capability and rebuild the regenerative immune microenvironment through bioenergetic activation. Under local mechanical stress, the piezoelectric hydrogel generated
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Engineered 3D liver-tissue model with minispheroids formed by a bioprinting process supported with in situ electrical stimulation Bioact. Mater. (IF 18.9) Pub Date : 2024-02-14 WonJin Kim, GeunHyung Kim
Three-dimensional (3D) bioprinting, an effective technique for building cell-laden structures providing native extracellular matrix environments, presents challenges, including inadequate cellular interactions. To address these issues, cell spheroids offer a promising solution for improving their biological functions. Particularly, minispheroids with 50–100 μm diameters exhibit enhanced cellular maturation
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Structural and temporal dynamics analysis of zinc-based biomaterials: History, research hotspots and emerging trends Bioact. Mater. (IF 18.9) Pub Date : 2024-02-10 Kunshan Yuan, Chengchen Deng, Lili Tan, Xiangxiu Wang, Wenhua Yan, Xiaozhen Dai, Ruolin Du, Yufeng Zheng, Haijun Zhang, Guixue Wang
To examine the 16-year developmental history, research hotspots, and emerging trends of zinc-based biodegradable metallic materials from the perspective of structural and temporal dynamics. The literature on zinc-based biodegradable metallic materials in WoSCC was searched. Historical characteristics, the evolution of active topics and development trends in the field of zinc-based biodegradable metallic
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Effect of chitin-architected spatiotemporal three-dimensional culture microenvironments on human umbilical cord-derived mesenchymal stem cells Bioact. Mater. (IF 18.9) Pub Date : 2024-02-09 Shuoji Zhu, Junfeng Xuan, Yunchao Shentu, Katsuhiko Kida, Masaki Kobayashi, Wei Wang, Minoru Ono, Dehua Chang
Mesenchymal stem cell (MSC) transplantation has been explored for the clinical treatment of various diseases. However, the current two-dimensional (2D) culture method lacks a natural spatial microenvironment . This limitation restricts the stable establishment and adaptive maintenance of MSC stemness. Using natural polymers with biocompatibility for constructing stereoscopic MSC microenvironments may
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An Injectable silk-based hydrogel as a novel biomineralization seedbed for critical-sized bone defect regeneration Bioact. Mater. (IF 18.9) Pub Date : 2024-02-08 Yuhui Zhu, Hao Gu, Jiawei Yang, Anshuo Li, Lingli Hou, Mingliang Zhou, Xinquan Jiang
The healing process of critical-sized bone defects urges for a suitable biomineralization environment. However, the unsatisfying repair outcome usually results from a disturbed intricate milieu and the lack of in situ mineralization resources. In this work, we have developed a composite hydrogel that mimics the natural bone healing processes and serves as a seedbed for bone regeneration. The oxidized
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Wet environment-induced adhesion and softening of coenzyme-based polymer elastic patch for treating periodontitis Bioact. Mater. (IF 18.9) Pub Date : 2024-02-07 Ying Qi, Chenyu Xu, Zhuodan Zhang, Qian Zhang, Ziyang Xu, Xinrui Zhao, Yanhong Zhao, Chunyan Cui, Wenguang Liu
Periodontitis, a common chronic inflammatory disease caused by pathogenic bacteria, can be treated with diverse biomaterials by loading drugs, cytokines or proteins. However, these biomaterials often show unsatisfactory therapeutic efficiency due to their poor adhesion, short residence time in the wet and dynamic oral cavity and emerging drug resistance. Here we report a wet-responsive methacrylated
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Reversing cancer immunoediting phases with a tumor-activated and optically reinforced immunoscaffold Bioact. Mater. (IF 18.9) Pub Date : 2024-02-03 Xinchao Li, Xiuqi Liang, Wangxian Fu, Rui Luo, Miaomiao Zhang, Xiaorong Kou, Yi Zhang, Yingjie Li, Dongxue Huang, Yanjie You, Qinjie Wu, Changyang Gong
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Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair Bioact. Mater. (IF 18.9) Pub Date : 2024-02-03 Zhaoping Wu, Yi Zhou, Xianglin Hou, Weidong Liu, Wen Yin, Lei Wang, Yudong Cao, Zhipeng Jiang, Youwei Guo, Quan Chen, Wen Xie, Ziqiang Wang, Ning Shi, Yujun Liu, Xiang Gao, Longlong Luo, Jianwu Dai, Caiping Ren, Xingjun Jiang
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Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications Bioact. Mater. (IF 18.9) Pub Date : 2024-02-02 Rongqiu Mu, Danzhu Zhu, Sama Abdulmalik, Suranji Wijekoon, Gang Wei, Sangamesh G. Kumbar
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Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification Bioact. Mater. (IF 18.9) Pub Date : 2024-02-02 Lili Sun, Haoyi Niu, Yuqiong Wu, Shiyan Dong, Xuefeng Li, Betty Y.S. Kim, Changsheng Liu, Yifan Ma, Wen Jiang, Yuan Yuan
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Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease Bioact. Mater. (IF 18.9) Pub Date : 2024-01-28 Zhangpeng Shi, Xiaohong Li, Jufeng Chen, Zideng Dai, Yefei Zhu, Tan Wu, Qing Liu, Huanlong Qin, Yang Zhang, Hangrong Chen
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Silk fibroin-based inks for in situ 3D printing using a double crosslinking process Bioact. Mater. (IF 18.9) Pub Date : 2024-01-25 Francesca Agostinacchio, Vincent Fitzpatrick, Sandra Dirè, David L. Kaplan, Antonella Motta
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Convergence of nanomedicine and neutrophils for drug delivery Bioact. Mater. (IF 18.9) Pub Date : 2024-01-27 Sichen Yuan, Quanyin Hu
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Nanoadjuvant-triggered STING activation evokes systemic immunotherapy for repetitive implant-related infections Bioact. Mater. (IF 18.9) Pub Date : 2024-01-24 Dongdong Xu, Jun Hu, Jiawei Mei, Jun Zhou, Zhengxi Wang, Xudong Zhang, Quan Liu, Zheng Su, Wanbo Zhu, Hongjian Liu, Chen Zhu
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A theragenerative bio-nanocomposite consisting of black phosphorus quantum dots for bone cancer therapy and regeneration Bioact. Mater. (IF 18.9) Pub Date : 2024-01-24 Ashkan Bigham, Ines Fasolino, Silvia Borsacchi, Carmen Valente, Lucia Calucci, Gabriele Turacchio, Marianna Pannico, Manuel Serrano-Ruiz, Luigi Ambrosio, Maria Grazia Raucci
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Extracellular vesicles released by transforming growth factor-beta 1-preconditional mesenchymal stem cells promote recovery in mice with spinal cord injury Bioact. Mater. (IF 18.9) Pub Date : 2024-01-25 Guoliang Chen, Shiming Li, Kuileung Tong, Zerong Huang, Shuangjiang Liu, Haoran Zhu, Yanheng Zhong, Zhisen Zhou, Genlong Jiao, Fuxin Wei, Ningning Chen
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Nano oxygen chamber by cascade reaction for hypoxia mitigation and reactive oxygen species scavenging in wound healing Bioact. Mater. (IF 18.9) Pub Date : 2024-01-23 Xiaoxue Han, Leah Ju, Chai Saengow, Wen Ren, Randy Ewoldt, Timothy Fan, Joseph Irudayaraj
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Highly active probiotic hydrogels matrixed on bacterial EPS accelerate wound healing via maintaining stable skin microbiota and reducing inflammation Bioact. Mater. (IF 18.9) Pub Date : 2024-01-19 Hongtao Xu, Yaqian Li, Jiangping Song, Liuyang Zhou, Kaizhang Wu, Xingyu Lu, XiaoNing Zhai, Zhili Wan, Jie Gao
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Ultrasound-mediated drug-free theranostics for treatment of prostate cancer Bioact. Mater. (IF 18.9) Pub Date : 2024-01-20 Reshani Himashika Perera, Felipe Matias Berg, Eric Chua Abenojar, Pinunta Nittayacharn, Youjoung Kim, Xinning Wang, James Peter Basilion, Agata Exner
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Accelerated corrosion of 316L stainless steel in a simulated oral environment via extracellular electron transfer and acid metabolites of subgingival microbiota Bioact. Mater. (IF 18.9) Pub Date : 2024-01-20 Ying Zheng, Yi Yang, Xianbo Liu, Pan Liu, Xiangyu Li, Mingxing Zhang, Enze Zhou, Zhenjin Zhao, Xue Wang, Yuanyuan Zhang, Bowen Zheng, Yuwen Yan, Yi Liu, Dake Xu, Liu Cao