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Hard and soft tissue engineering for peri-implant defects; a narrative review Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-03-13 Nikta Ranjbar, Mona Sharifmoghaddam, Narges Afra, Samira Afshar Fard, Ailar Zandi, Mina Hosseini, Faraz Sedaghat, Ghasem Barati, Ehsan Saburi
Tissue engineering is aimed to regenerate damaged or lost tissues by exploiting polymeric scaffolds, proper cells, and growth factors. Both hard and soft tissue damages in proposed implant sites ar...
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Low fouling and pH-responsive poly(N-vinyl imidazole)/poly(ethylene glycol) methacrylate copolymer gels for colon targeted diclofenac sodium delivery Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-03-12 Selma Ustürk, Elvan Yilmaz, Ergül Mutlu Altundağ
Protein and cell adhesion onto drug delivery matrices interferes with the predesigned drug delivery profile to the targeted site. Antifouling surfaces are needed to overcome this problem and improv...
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Nanomicelle carrier developed using biosurfactants: a novel approach for selective gene targeting Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-03-06 Dilpreet Singh
Gene therapy has emerged as a promising avenue for treating genetic disorders, cancer, and other diseases by introducing therapeutic genes or modulating gene expression. However, the success of gen...
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Electrospun nanofibers of carbohydrate polymers for neoteric wound dressing: a review Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-26 Malati Salunke, Viswapriya Viswalingam, Vaibhav Shinde
The global demand for wound dressing material has increased, and conventional dressings are unable to meet needs due to various limitations. Researchers have recently turned to electrospinning, a v...
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Smart and intelligent biomaterials for novel applications – a review Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-20 Beletech Alemu Reta, Murugesh Babu K, Tamrat Tesfaye
Intelligent materials are used to create novel biomaterials that can recognize and respond to environmental cues, as well as perform specific tasks for modern medicine and sustainability. There are...
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Strategic aspect for improving the sensitivity of nanoparticles in biomedical sciences Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-20 Kanchi Acharya, Bhagyashree V. Salvi, Pravin Shende
Conjugation of nanoparticles (NPs) with oligonucleotides and molecular moieties ameliorates the sensitivity and selectivity of nanoparticles for the biomedical applications like diagnosis, drug del...
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Polyzwitterion coating based on PDMAEMA-block-PAAc for catheters with antibiofilm activities Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-20 Bakhshali Massoumi, Raana Sarvari, Elaheh Fakhri
Patients with long-term indwelling urinary catheters suffer from complications like infection and encrustation, which are dealt with by catheter replacement or antibiotic therapy inevitably resulti...
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Fabricating biomimetic porous PEEK scaffolds for bone implants Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-18 Hanyu Zhu, Vincent Y. Wang, Wei Li
Poly-ether-ether-ketone (PEEK) is a high strength polymer with strong potential for medical use, especially for bone implants. In this research, a novel method of making biomimetic porous PEEK scaf...
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Biological, anti-inflammatory and antioxidant activity of c-PEI based silica nano composites Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-15 Eman H. Ahmed, Hassan M. Awad, Azza M. Noor El Deen
In this study, a mixed sol-gel technique using silicate, polyvinyl alcohol (PVA), and polyethyleneimine (PEI) was used to various polymers based on PEI and silica gel. The c-PEI blend co-polymer wa...
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3D-printed hydrogels based on amphiphilic chitosan derivative loaded with levofloxacin for wound healing applications Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-13 Maria Lazaridou, Sofia Moroni, Panagiotis Klonos, Apostolos Kyritsis, Dimitrios N. Bikiaris, Dimitrios A. Lamprou
Skin wounds not only cause physical pain to patients but also pose an economic burden to society. Consequently, effective approaches to promote skin repair remain a challenge. Specifically, chitosa...
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Applications of biodegradable polymers and ceramics for bone regeneration: a mini-review Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-13 Maryam Batool, Muhammad Amin Abid, Tariq Javed, Muhammad Nouman Haider
The current review presents an insight into the recent developments of biodegradable materials used for orthopedic surgery and bone regeneration purposes. Conventional biodegradable devices for ost...
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Manipulation of biophysicochemical behavior of transporters using nanodimensional coating Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-15 Jheel Dholakia, Bala Prabhakar, Jay Bajaj, Pravin Shende
Nanocoating is a layer or coating on various drug delivery systems and medical devices within the nanometer range to improve the physicochemical properties, stability, compatibility and protect the...
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The potential of an electrospun poly (3-hydroxybutyrate)/poly (ethylene glycol) blend fibrous scaffold for cartilage tissue engineering Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-13 Elham Naghashzargar, Maryam Aghajani, Marziyeh Ranjbar-Mohammadi
Poly (3-hydroxybutyrate) and poly (ethylene glycol) are frequently used as materials for designing scaffolds in tissue engineering. This work aimed the production of P3HB-PEG scaffolds in different...
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Fabrication and characterization electrospun nanofibers of vitamin E-loaded poly(vinyl alcohol) and hydroxy-beta-cyclodextrin crosslinked by citric acid Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-13 Titapa Singchuwong, Kanokwan Nankuntod, Kunyalux Stapornpiriyadaj, Theerachart Leepasert, Thitinun Karpkird
Electrospun fibers were developed using different ratios of PVA/CD crosslinked with citric acid to enhance their water resistance properties. The diameter of the fibers increased as the amount of C...
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Synthesis, characterization and bio-activity assessment of copper complex based on a novel terpolymer Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-02-04 Nagoor Mujafarkani, Fazul Mohamed Mashood Ahamed, Mozhgan Afshari, Sónia A. C. Carabineiro
In this study, a novel terpolymer was successfully obtained via the polycondensation polymerization of p-phenylenediamine and 2-aminothiazole with formaldehyde, employing dimethylformamide as a cat...
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Smart mucoadhesive 3-D network hydrogels for use in localized impregnated anticancer drug delivery Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-30 Vikrant Sharma, Prerna Sharma, Disha Kapil, Baljit Singh
Recently, bioactive dietary fibers (DFs) have been explored for various benefits to human health because of their therapeutic activities. Role of DF psyllium (arabinoxylan (Ax)) has been establishe...
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PAM-based hydrogels characterization as a potential biomaterial for mammography QC-phantoms development Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-29 Abraham González-Ruíz, Helen’s Irais Sánchez Mendoza, Clara Leticia Santos-Cuevas, Huemantzin Balan Ortiz-Oliveros, Jaime Flores-Estrada, María Victoria Dominguez-García, Miriam V Flores-Merino
Hydrogels can mimic three-dimensional characteristics of human tissues, which can be used to evaluate diagnostic X-ray equipment quality control features. In this study, polyacrylamide hydrogels (P...
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Summary on polyurethane-based drug delivery system in perspective for future implantable drug system Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-24 Neeraja Bose, Kalaivizhi Rajappan
Recent research is based on biocompatible drug delivery systems due to the need for bioavailability, route of administration, dose dumping, and first-pass metabolism. Despite its excellent mechanic...
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In vivo investigations of polymers in bone tissue engineering: a review study Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-22 Ali A. Al-allaq, Jenan S. Kashan, Farah M. Abdul-Kareem
Bone tissue engineering (BTE) applications and regenerative strategies have been used to improve the clinical practice of repairing large bone defects associated with surgical resections, congenita...
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Biopolymer and polymer-based composites for lung tissue regeneration in fighting against coronavirus disease 2019: a review Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-22 Farzaneh Jabbari, Valiollah Babaeipour
Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), the respiratory disease Corona-19 agent, significantly damages the respiratory system, especially the lungs. Biopolymers have great pot...
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Ion pair self-assembly composed of polyamidoamine dendrimer and phenylthio acetic acid and its temperature and oxidation-responsive release property Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-22 Kwanjira Wangpimool, Jin-Chul Kim
Polyamidoamine (PAMAM) dendrimer/phenylthio acetic acid (PTA) ion pair could be generated when the amino/carboxyl group ratio was 3/7 to 1/9. The chemical shifts on 1H NMR and FT-IR spectra suggest...
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Recent advances in polymer-based scaffolds for cardiac tissue engineering Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-18 Nazanin Amiryaghoubi, Marziyeh Fathi, Yousef Javadzadeh
Cardiovascular disease such as myocardial infarction is one of the chief reasons for death universally. An extensive variety of natural and synthetic biodegradable polymers have been studied lately...
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Natural polymer-based hydrogels: versatile biomaterials for biomedical applications Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-18 Neeti Angaria, Sumant Saini, Md. Sadique Hussain, Sakshi Sharma, Gurvinder Singh, Navneet Khurana, Rajesh Kumar
Hydrogels are insoluble three-dimensional polymer networks that are water insoluble but can absorb large amounts of water or biological fluid. They can be prepared using a variety of polymers, incl...
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Advanced biomaterials for tendon repair: development and application Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-18 Ye Shen, Yan Xu, Jishizhan Chen
Professional sports such as tennis training require repetitive shoulder movements, which can result in tendon fatigue and injury due to overuse. This injury usually occurs when an incorrect force i...
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Anionic magnetic nanosorbents immobilized with peptide aptamer for selective adsorption with bisphenol A Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-12 Wasawat Inthanusorn, Boonjira Rutnakornpituk, Metha Rutnakornpituk
This study focused on synthesis of anionic magnetite nanoparticles (MNPs) immobilized with a bisphenol A (BPA)-specific peptide aptamer for selective BPA adsorption. The MNP surface was coated with...
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Conductive electrospun nanofiber based on silk fibroin/cellulose nanocrystals/reduced graphene oxide as a wound healing material Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-09 Bakhshali Massoumi, Raana Sarvari, Elaheh Fakhri
Composite electrospun nanofibers based on silk fibroin (SF), aminated reduced graphene oxide (NH2rGO), and oxidized-cellulose nanocrystals (AD-CNCs) were designed to promote the healing process by ...
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Unveiling hydrogel’s prominence: a breakthrough in topical formulations for psoriasis treatment Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-09 Prem Dutt, Gautam Singhvi, Yashika Tomar, Sahil Sain, Vikas Rana
Psoriasis is chronic autoimmune inflammatory skin disorder affecting millions of people worldwide (2–3% of world population). Treatment of psoriasis ranges from use of topicals to biologicals. Alth...
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GelMA - PVAMA hydrogel loaded with MYDGF accelerates wound healing by promoting angiogenesis Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-12 Sizhen Huang, Haodi Kou, Zhichao Zheng, Ming Lu, Lihong Wu, Huade Zheng
Angiogenesis within the wound site is a necessary prerequisite for skin tissue regeneration during the process of wound healing. Skin vessels provide adequate nutrients and soluble bioactive factor...
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Recent advancements and various potential applications of transdermal patches Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-08 Ansa Abdul Razzaq, Tehseen Riaz, Muhammad Zaman, Muhammad Ahsan Waqar, Ansa Ashfaq
In the recent years, transdermal drug delivery system (TDDS) has gained a lot of success for drug delivery. Transdermal patches have been utilized for delivering the drugs via TDDS. These patches d...
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Graphene oxide-modified polythiophene nanohybrids: antibacterial properties and sonophotocatalytic degradation of dyes under visible-light irradiation Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2024-01-02 Shamella Myrick, Faith Nwanze, Audrey F Adcock, Xiuli Dong, Liju Yang, Ufana Riaz
The present work highlights the synthesis of graphene oxide (GO) modified polythiophene (PTh) for its application as an antibacterial agent as well as a visible light active photocatalyst. PTh was ...
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Nafion based biosensors: a review of recent advances and applications Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-12-25 Roya Mohammadzadeh Kakhki
Nafion is a sulfonated tetrafluoroethylene based fluoropolymer that has been widely used as a membrane material for various applications, such as fuel cells, batteries, and sensors. Nafion has some...
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Polyacrylonitrile (PAN)/carbon nanotube (CNT) electrospun nanofibers: synthesis, characterization, their biocompatibility for L929 fibroblast cells and molecular docking studies Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-12-23 Atike Ince Yardimci, Dogukan Mutlu, Erman Salih Istifli, Sevki Arslan, Shayesteh Poorhosein Ghazi Mahaleh, Nesli Yagmurcukardes, Pinar Kara, Recep Liman
There has been an important interest in to use of electrospun nanomaterials for tissue engineering applications due to the excellent scaffold-cell interaction provided by high interconnectivity and...
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Synthesis, characterization, sorption, and antibacterial properties of a new polystyrene-supported o-hydroxyacetophenonediethylenetriamine polymer Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-12-15 Nora Guemmaz, Salim Madani, Kamel Mokhnache, Ahlem Karbab, Daniel L. Garcia, Marta F. Garcia, Lekhmici Arrar, Noureddine Charef, Mohammad S. Mubarak
A new polystyrene-supported Schiff base resin, o-hydroxyacetophenonediethylenetriamine-polystyrene (PS-HAPDA), has been synthesized via a reaction between the commercially available chloromethyl po...
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Nanotechnology-enabled therapies improve blood-brain barrier challenges in brain tumor Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-12-12 Yan Wenqi, Wei Lingxi, Arshad Mehmood, Wahid Shah
The treatment of brain tumors has been predominantly hindered by the limited ability of drugs to penetrate the blood-brain barrier. However, recent advancements in nanotechnology have presented a t...
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Co-electrospun (polyvinyl alcohol/Lepidium perfoliatum seed gum)-polycaprolactone hybrid nanofibers for antibacterial wound dressing applications Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-12-14 Javad Yekrang, Alireza Yousefi
Lepidium perfoliatum seed gum (LPSG) biopolymer was co-electrospun in a hybrid nanofiber (HNF) structure using polyvinyl alcohol and polycaprolactone polymers. The obtained results showed the impro...
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Synthesis of the glycodendrimer macromolecule based on porphyrin as a targeted drug delivery system Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-12-11 Rezvan Shojaei, Hossein Mighani, Elham Yeganeh-Salman, Pouya Taheri, Moein Ghorbanian, Raha Mokhtari Aghdami
The present study synthesized a novel dendrimer with specific functional groups and use them as pharmaceutical carriers at the nanoscale. First, a glycodendrimer was synthesized and a porphyrin sub...
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Fabrication and in vitro characterization of delafloxacin-laden electrosprayed hydroxypropyl cellulose nanoparticulated solid dispersions for enhanced aqueous solubility and release rate of the drug Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-12-11 Muhammad Ramzan, Abid Mehmood Yousaf, Ikram Ullah Khan
With the aim of fabricating and characterizing an optimized drug delivery system (DDS) for an effective administration of poorly water-soluble delafloxacin (DFX) via the oral route, several formula...
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A new starch based wound dressing modified by graphene oxide/silver nanowire nanoparticles Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-12-11 Negar Hosseini Darabi, Mohammadreza Kalaee, Saeedeh Mazinani, Ramin Khajavi
Considering the special effect of wound treatment in the field of medicine, antibacterial wound dressings preparation is one of the main challenges in successful wound healing. In this research, a ...
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Fabrication of a tri-layer scaffold with dual release of heparin and PRP for tissue engineering of small‐diameter blood vessels Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-12-11 Anousheh Zargar Kharazi, Aida Ghebleh, Laleh Shariati
A tri-layer scaffold was fabricated according to functionally graded materials (FGM) theory from poly(glycerol sebcate)/poly(L-lactic acid) blend by the increasing polylactic acid ratio from the in...
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Micro texturing and laser irradiation, two stimulus of growth and differentiation to neural like cell on the PMMA polymer Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-11-27 Somayeh Hashamdar, Parviz Parvin, Sara Mayahi, Behnaz Rahimi, Mitra Refahizadeh, Fatemeh Ramezani
Nerve injuries and neurodegenerative disorders remain serious challenges due to the poor results of nerve cell regeneration. The most promising treatment for such injuries is treatments based on st...
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Preparation of hydrophobic acrylic intraocular lens materials using various crosslinking agents to reduce glistening Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-11-24 Tae Hyoung Kim, Byung Yi Ko, Ki Chang Song
Glistening is the condensation of water that forms within the intraocular lens (IOL) materials. In this study, a new approach was attempted to reduce the glistening using various types and content ...
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Hybrid nanoarchitecture of gelatin-modified silica-chitosan as an efficient delivery platform and functional role of crosslinking Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-11-15 Zahra Niazi, Mohsen Ashjari
A novel hybrid of a quercetin-loaded silica-chitosan, modified by crosslinked gelatin-folate was developed in the current study as a pH-sensitive drug delivery system. The entrapment efficiency of ...
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Targeted co-delivery of paclitaxel and chrysin by hyaluronate/chitosan-coated polymeric nanoparticles for prostate cancer chemotherapy Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-11-12 Behzad Jamali, Sajjad Jamali, Sevil Vaghefi Moghaddam, Mohsen Firoozrai, Soodabeh Davaran, Fatemeh Abedi
Chemotherapy is one of the most common therapeutic approaches in most cancers like prostate cancer, which has always faced limitations. The purpose of the present study was to design and prepare th...
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Polycaprolactone, polylactic acid, and nanohydroxyapatite scaffolds obtained by electrospinning and 3D printing for tissue engineering Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-11-07 Omar Alejandro González Rodríguez, Nancy Cecilia Ramírez Guerrero, Rocio Guadalupe Casañas Pimentel, Mónica Rosalia Jaime Fonseca, Eduardo San Martín Martínez
There is a deficit for bone tissue natural grafts that seek to be covered with synthetic substitutes. Scaffolds generated with 3D printing and electrospinning allow adequate mechanical properties m...
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Surface active polyesters based on N-substituted glutamic acid as promising materials for biomedical applications Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-11-06 Nataliia Fihurka, Ihor Tarnavchyk, Nataliya Nosova, Serhii Varvarenko, Iryna Dron, Dmytro Ostapiv, Vasyl Vlislo, Volodymyr Samaryk
In the present work, N-substituted glutamic acid, polyethylene and polypropylene glycols have been used to design biocompatible copolyesters via Steglich reactions. Due to the presence of alternati...
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Design, optimization & characterization of niosomal & polymeric nanoparticles Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-11-03 Fatima Tariq, Muhammad Zaman, Muhammad Ahsan Waqar, Muhammad Asad Saeed, Rai Muhammad Sarfraz
Niosomal and Polymeric-based nanoparticles offer advantages over conventional systems, such as targeted drug delivery and reduced toxicity. These nanoparticles are very promising due to their high ...
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A pH-sensitive magnetic hydrogel nanocomposite based on alginate for controlled release of methotrexate Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-10-30 Fahimeh Farshi Azhar, Aylin Ahmadinia, Hanieh Mousazadeh, Elnaz Kheirkhah
Development of a carrier with controlled release manner for methotrexate (MTX), an anticancer drug with short elimination half-life of 3-10 h, is important to overcome undesired side effects of con...
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Synthesis and characterization of multi-targeted polymeric antibody-microparticle conjugates with controlled drug release Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-10-27 Lucia Fernandez, Shannon Oakes, John Cipullo, Cole Moros, Jenna Hofman, Noelle Comolli
The presented experiments aimed to synthesize multi-targeted polymeric antibody-microparticles for the treatment of CD19+/CD20+ cancers. It is hypothesized that (1) targeting multiple tumor specifi...
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Nano-drug delivery systems based on biodegradable polymers for the therapy of gynecological malignancies Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-09-29 Keer Jin, Hanxue Zhang, Yuwei Yang, Yan Gao
Gynecological malignancies are the main factors that seriously endanger the life and health of women worldwide. Chemotherapy is one of the traditional methods for the treatment of gynecological mal...
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Kartogenin-loaded silk fibroin–chondroitin sulfate hybrid hydrogel with tailored β-sheet content: control release studies and biological activity Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-09-22 Maryam Farokhi, Atefeh Solouk, Hamid Mirzadeh, Heinz Redl, Andreas Teuschl-Woller
Silk fibroin (SF)–chondroitin sulfate (CS)-hybrid hydrogels (HHGs) containing kartogenin (KGN) were synthesized by the induction of di-tyrosine bonds, using enzymatic crosslinking in SF/CS blend so...
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Design of layer-by-layer lipid-polymer hybrid nanoparticles to elicit oral bioavailability of buspirone hydrochloride Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-09-11 Pankaj Dangre, Kajal Sonawane, Kailas Moravkar, Anil Pethe, Shailesh Chalikwar, Vivek Borse
Abstract Polyelectrolyte multilayer (PEM) was developed through layer-by-layer (LbL) adsorption on sodium alginate on negatively charged lipid polymer hybrid nanoparticles (LPHNPs) for the delivery of Buspirone hydrochloride (BUH). The resultant BUH-LPHNPs (F2) showed a mean particle size of 166 ± 4.2 nm and zeta potential of −30.5 ± 1.52 mV. The BUH-LPHNPs were found to be stable and demonstrated
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Preparation and sustained release bacteriostatic performance of pH-responsive complex hydrogel bacteriostatic microspheres for oral drug delivery Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-09-08 Wenqin Xu, Xing Li, Xianmei Wu, Guanghua Pan, Nanchun Chen, Xiuli Wang, Qinglin Xie
Abstract pH-responsive hydrogel antibacterial microspheres were prepared by complex coacervation method and used as drug carriers to load the antibiotic substitute potassium diformate (KDF). The results showed that the three-dimensional network structure of the composite hydrogel was formed among the polysaccharide components, and Zeolite A loaded with KDF was uniformly dispersed in it. The results
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Advances of multifunctional hydrogel-based therapy system for postoperative treatment of tumor Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-09-09 Jie Cai, Jun Wang, Minbo Liu, Lihua Zhu, Zhi Zhao, Bingkai Fan, Qun Yang, Jiewei Sun, Chenghu Wu
Abstract Surgical resection is presently the primary treatment method for solid tumors due to its capability to eliminate tumor tissue to the maximum extent and decrease the malignant proliferation rate of tumor cells. While some patients may benefit from the procedure, a significant number of patients are vulnerable to complications such as postoperative inflammatory toxicity, malformed tissue repair
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Bio-inspired nanoporous scaffold: electrospun hybrid fibers based on self-assembled block copolymer mineralized with inorganic nanoparticles for bone tissue engineering Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-09-04 Filipa Leal, Viraj Nirwan, Andreia M. Gonçalves, Nikolai Panitschewski, Eva Filová, Amir Fahmi, Pedro F. Costa
Abstract Mineralized, bio-inspired nanofibrous scaffolds with controllable architecture and capable of mimicking essential characteristics of bone extracellular matrix at the micro- and nanoscale offer a promising strategy to restore functions or elicit favorable responses for bone tissue regeneration and repair. In this study, a simple approach to fabricate a hybrid scaffold with porous fibers for
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Quercetin-incorporated collagen/chitosan/SiO2 composite toward the robust antioxidant biomaterials Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-08-31 Trung Hieu Le, Thi Hong Chuong Nguyen, Thi Van Thi Tran, Lam Son Le, Xuan Anh Vu Ho, Thanh Minh Tran, Thuy Trang Le, Hoang Luong Ngoc Nguyen, Minh Tuan Nguyen Dinh, Thi Hang Nga Phan, Thi Lan Huong Hoang, Chinh Chien Nguyen, Quyet Van Le
Abstract This investigation aims at providing a novel approach to producing high-performance antioxidant material. Indeed, quercetin molecules incorporated into collagen/chitosan/SiO2 composite through direct interactions have been reported for the first time. Such internal linking has been found as the primary reason for improving the stability of the entire system and enhancing the permanent existence
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Electrospun SF/GO/VEGF/GAS-LP scaffolds with synergistic sequential drug release and electrical stimulation for accelerated peripheral nerve regeneration Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-08-26 Jiashuo Liu, Runzhi Xiang, Hongtao Li, Hong Zhu, Jiarui Dang, Zhihui Ran, Huan Deng, Wenjin Xu, Chengjie Xiong, Zhijun Huang, Peihu Xu, Haixing Xu
Abstract Here, a novel kind of composite scaffold was fabricated by loading vascular endothelial growth factor (VEGF) and gastrodin liposome (GAS-LP) into electrospun silk fibroin/graphene oxide(SF/GO)nanofibrous and silk fibroin sponge-filled, respectively. Our results demonstrated that VEGF and GAS exhibited different release patterns in vitro which VEGF showed rapid release rate in the first few
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Nanocomplex of nisin with carbohydrate for the treatment of tuberculosis Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-08-26 Janhavi Bhavsar, Pravin Shende
Abstract AMPs are neutral and small size component of the immune system and showed better activity for the treatment of tuberculosis. The present study aimed to complex nisin with carbohydrate to increase bioavailability and provide site-specific action at lungs via pulmonary route. Nanocomplexes were prepared by kneading method and then adsorbed on lactose for DPI formulation. Nanocomplex of nisin
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Preparation of elastic hydrogel films via in-situ ketalization of Poly(vinyl alcohol) and ZnO nanoparticle doped Poly(vinyl ketal) films as antibacterial surface Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-08-24 Ayşegül Özbal, Zeynep Dikmen, Vural Bütün
Cross-linked and flexible poly(vinyl acetone ketal) (PV-A-K) films have been prepared as a result of ketalization reaction and monolith formation of poly(vinyl alcohol) (PVA), which has the feature...
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Multi-drug delivery and osteogenic performance of β-tricalcium phosphate/alginate composite microspheres Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-08-23 Fu Qingyun, Guo Zhenzhao, Bo Dongyin, Huang Ke, Su Ziyu, Jin Weihong, Yu Zhentao, Xu Shulan, Li Hong
Abstract To address the insufficiencies in the systemic research of calcium phosphate/alginate (ALG) microspheres for multi-drug delivery and bone formation, this study investigated the multi-drug release kinetics and osteogenic behaviors of β-tricalcium phosphate/ALG microspheres. The results showed that different loaded drugs exhibited an early burst release phenomenon, and the drug loading capacity
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Preparation and properties of polyurethane film dressing modified by catechol grafted oligochitosan Int. J. Polym. Mater. Polym. Biomater. (IF 3.2) Pub Date : 2023-08-14 Xiue Ren, Chenyang Fan, Bizhen Yuan, Yinnian Liao, Jiayi Tu, Changren Zhou, Shuyi Xia, Haijie He
Abstract In this study, carbon-carbon double bonds and catechol groups modified oligochitosan (OCS)/photocurable polyurethane composite films (OPU) were prepared for wound dressing application. Methacrylic anhydride (MA) was used to modify oligochitosan. The effect of the ratio of amino groups on OCS to MA on the properties of the composite films was investigated. The results showed that the OPU films