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A silk-based hydrogel containing dexamethasone and lipoic acid microcrystals for local delivery to the inner ear Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-16 Haixia Xiong, Peili Zhang, Dongcheng Wang, Zhimin Zhou, Jianjun Sun, Mingfang Diao
Local drug delivery has been exploited recently to treat hearing loss, as this method can both bypass the blood-labyrinth barrier and provide sustained drug release. Combined drug microcrystals (MCs) offer additional advantages for sensorineural hearing loss treatment via intratympanic (IT) injection due to their shape effect and combination strategy. In this study, to endow viscous effects of hydrogels
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Carrageenan films as promising mucoadhesive ocular drug delivery systems Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-16 Aleksandra V. Volod’ko, Elvira Yu. Son, Valery P. Glazunov, Viktoriya N. Davydova, Elga I. Alexander-Sinkler, Svetlana A. Aleksandrova, Miralda I. Blinova, Irina M. Yermak
Polymer mucoadhesive films being developed for use in ophthalmology represent a new tool for drug delivery and are considered an alternative to traditional dosage forms. Due to their mucoadhesive properties, carrageenans (CRGs) are widely used in various forms for drug delivery. In this study, films based on CRGs of various structural types (κ/β, κ, x, and λ) for use in ophthalmology were studied.
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Eudragit S100 coated nanodiamond-based nanoparticles as an oral chemo-photothermal delivery system for local treatment of colon cancer Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-13 Yupei Su, Hao Pan, Jiahui Wang, Dandan Liu, Weisan Pan
Oral colonic nano-drug delivery system has received more and more attention in the treatment of colon cancer due to local precision treatment and reduction of drug system distribution. However, the complex and harsh gastrointestinal environment and the retention of nanoparticles in the colon limit its development. To this end, we designed Eudragit S100 (ES) coated nanoparticles (ES@PND-PEG-TPP/DOX)
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Phyto-cosmeceutical gel containing curcumin and quercetin loaded mixed micelles for improved anti-oxidant and photoprotective activity Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-12 Monica Rao, Pranjali Gaikwad, Poonam Misal, Santosh V Gandhi
Ultra Violet radiations induced skin damage and associated skin disorders are a widespread concern. The consequences of sun exposure include a plethora of dermal conditions like aging, solar urticaria, albinism and cancer. Sunscreens provide effective protection to skin from these damages. Besides FDA approved physical and chemical UV filters, phytoconstituents with their multi functionalities are
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Covalent modification of γ-cyclodextrin with geraniol: An antibacterial agent with good thermal stability, solubility and biocompatibility Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-12 Xiaowei Ding, Xuerong Luo, Imran Mahmood Khan, Lin Yue, Yin Zhang, Zhouping Wang
Geraniol (Ger) is an essential oil molecule with excellent biological activity. High hydrophobicity and volatility limit its practical application. Cyclodextrins (CDs) are water-soluble cyclic oligosaccharides with hydrophobic cavities. Physical encapsulation of CDs to improve the solubility and stability of essential oil molecules is not satisfactory. Therefore, this study synthesized the γ-CD derivative
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Surfactant-based supramolecular dye assembly: A highly selective and economically viable platform for quantification of heparin antidote Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-12 Soumyadeep Sarkar, Goutam Chakraborty, Haridas Pal
Herein, we have employed a supramolecular assembly of a cationic dye, LDS-698 and a common surfactant sodium dodecyl sulfate (SDS) as a turn-on fluorescent sensor for protamine (Pr) detection. Addition of cationic Pr to the solution of dye-surfactant complex brings negatively charged SDS molecules together through strong electrostatic interaction, assisting aggregation of SDS way before its critical
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Promoting effect of phosvitin in the mineralization of eggshell inner membrane with the application in osteogenic induction scaffold Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-11 Wei Liu, Qiancheng Zhao, Cuie Tang, Zhaoxia Cai, Yongguo Jin, Dong Uk Ahn, Xi Huang
Exploring affordable and easily prepared inorganic-organic hybrid membrane materials has attracted a great interest in the bone repair field. This study is based on biomimetic mineralization technique to study the role of phosvitin (PV) in the mineralized process of eggshell inner membrane. Results showed that PV promoted the formation of hydroxyapatite on the eggshell inner membrane surface, and the
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Giant vesicles form in physiological saline and encapsulate pDNA by the modified electroformation method Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-11 Dingshan Zhang, Yangruizi Zhang, Yao Xiao, Yiting Wang, Yong Shen, Zhibiao Wang, Hai Qiao
Giant vesicles (GVs) are used to study the structures and functions of cells and cell membranes. Electroformation is the most commonly used method for GV preparation. However, the electroformation of GVs is hindered in highly concentrated ionic solutions, limiting their application as cell models for research under physiological conditions. In this study, giant multilayer vesicles were successfully
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Advances in self-assembled nanotechnology in tumor therapy Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-11 Yanting Kuang, Zhaokai Li, Hang Chen, Xinyu Wang, Yan Wen, Jianming Chen
The emergence of nanotechnology has opened up a new way for tumor therapy. Among them, self-assembled nanotechnology has received extensive attention in medicine due to its simple preparation process, high drug-loading capacity, low toxicity, and low cost. This review mainly summarizes the preparation methods of self-assembled nano-delivery systems, as well as the self-assembled mechanism of carrier-free
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Calcium-based MOFs as scaffolds for shielding immobilized lipase and enhancing its stability Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-09 Lili Xu, Xinyue Geng, Qi Li, Moju Li, Shu Chen, Xiangnan Liu, Xusheng Dai, Xiuhuan Zhu, Xuekun Wang, Hongbo Suo
The enzyme immobilization technology has become a key tool in the field of enzyme applications; however, improving the activity recovery and stability of the immobilized enzymes is still challenging. Herein, we employed a magnetic carboxymethyl cellulose (MCMC) nanocomposite modified with ionic liquids (ILs) for covalent immobilization of lipase, and used Ca-based metal–organic frameworks (MOFs) as
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Evaluating the hypolipidemic effect of garlic essential oil encapsulated in a novel double-layer delivery system Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-07 Xueli Zhang, Xu Guo, Jinyue Sun, Yingying Chen, Mengqi Zhang, Xiaozhen Tang, Wenliang Wang, Jesus Simal-Gandara, Huiying Xu, Ningyang Li, Chao Liu
The limited application of garlic essential oil (GEO) is attributed to its pungent taste, poor water solubility and low bioavailability. Liposomes are nontoxic, biodegradable and biocompatible, and β-cyclodextrin can inhibit undesirable odors and improve the stability and bioavailability. Thus a promising dual-layer GEO β-cyclodextrin inclusion compound liposome (GEO-DCL) delivery system with both
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Facile synthesis of manganese-hafnium nanocomposites for multimodal MRI/CT imaging and in vitro photodynamic therapy of colon cancer Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-06 Mingyue Cui, Zhe Tang, Zahoor Ahmad, Chunshu Pan, Yuguang Lu, Kamran Ali, Shuqi Huang, Xiaoqing Lin, Abdul Wahab, M. Zubair Iqbal, Xiangdong Kong
Precise diagnosis of complex and soft tumors is challenging, which limits appropriate treatment options to achieve desired therapeutic outcomes. However, multifunctional nano-sized contrast enhancement agents based on nanoparticles improve the diagnosis accuracy of various diseases such as cancer. Herein, a facile manganese-hafnium nanocomposites (MnO-HfO NCs) system was designed for bimodal magnetic
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Synergistic photoinduced charge transfer resonance from porous ZIF-67 decorated violet phosphorus array for SERS immunoassay of SARS-CoV-2 spike protein Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-04 Chucheng Wang, Jialong Zhao, Chenjie Gu, Tao Jiang, Xing Li
As a rapid, highly sensitive, and user-friendly technique, surface-enhanced Raman scattering (SERS) has an extraordinary appeal to home self-test of COVID-19 during the post pandemic era. However, most of the existing SERS substrates have been still criticized in stability, repeatability, and sample enrichment. To address these obstacles, a novel non-metallic SERS substrate with porous surfaces and
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Understanding the petal effect: Wetting properties and surface structure of natural rose petals and rose petal-derived surfaces Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-04 Sergio Parra-Vicente, Pablo F. Ibáñez-Ibáñez, Miguel Cabrerizo-Vílchez, Isabel Sánchez-Almazo, Miguel Ángel Rodríguez-Valverde, Francisco Javier Montes Ruiz-Cabello
The petal effect is identified as a non-wetting state with high drop adhesion. The wetting behavior of petal surfaces is attributed to the papillose structure of their epidermis, which leads to a Cassie-Baxter regime combined with strong pinning sites. Under this scenario, sessile drops are pearl shaped and, unlike lotus-like surfaces, firmly attached to the surface. Petal surfaces are used as inspiration
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The role of air relative humidity on the wettability of Pseudomonas fluorescens AR11 biofilms Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-03-02 Daniele Marra, Emilia Orillo, Giuseppe Toscano, Maria Petala, Thodoris D. Karapantsios, Sergio Caserta
Biofilms are complex porous materials formed by microorganisms, polysaccharides, proteins, eDNA, inorganic matter, and water. They are ubiquitous in various environmental niches and are known to grow at solid-liquid, solid-air and air-liquid interfaces, often causing problems in several industrial and sanitary fields. Their removal is a challenge in many applications and numerous studies have been
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Effective pickering emulsifiers based on submicron carboxymethyl cellulose/chitosan polymer particles Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-29 Emmanuel O. Mensah, Rita S. Alqubelat, Yaroslava A. Menzorova, Artem S. Minin, Maxim A. Mironov
In this study, cross-linked carboxymethyl cellulose/chitosan submicron particles were employed to facilitate the stabilization of Pickering emulsion. The polymer particles were prepared using the polyelectrolyte self-assembly method in conjunction with isocyanide based multicomponent reactions and the characteristics were obtained using: nuclear magnetic resonance, Fourier-transform infrared spectroscopy
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Glycerol- and diglycerol-based polyesters: Evaluation of backbone alterations upon nano-formulation performance Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-28 Eleni Axioti, Emily G. Dixon, Morgan Reynolds-Green, Euan C.H. Alexander, Benedetta Brugnoli, Daniel J. Keddie, Benoit Couturaud, Jiraphong Suksiriworapong, Sadie M.E. Swainson, Iolanda Francolini, Steven M. Howdle, Philippa L. Jacob, Robert J. Cavanagh, Veeren M. Chauhan, Vincenzo Taresco
Despite the success of polyethylene glycol-based (PEGylated) polyesters in the drug delivery and biomedical fields, concerns have arisen regarding PEG's immunogenicity and limited biodegradability. In addition, inherent limitations, including limited chemical handles as well as highly hydrophobic nature, can restrict their effectiveness in physiological conditions of the polyester counterpart. To address
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Dialysis-functionalized microfluidic platform for in situ formation of purified liposomes Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-28 Han Shan, Qi Sun, Yang Xie, Xiangdong Liu, Xiang Chen, Shuang Zhao, Zeyu Chen
Continuous-flow microfluidic devices have been extensively used for producing liposomes due to their high controllability and efficient synthesis processes. However, traditional methods for liposome purification, such as dialysis, gel chromatography, and ultrafiltration, are incompatible with microfluidic devices, which would dramatically restrict the efficiency of liposome synthesis. In this study
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Development of pH-freshness smart label based on gellan gum film incorporated with red cabbage anthocyanins extract and its application in postharvest mushroom Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-28 Shouqing Zhan, Fangxuan Yi, Fanyun Hou, Lisha Song, Xiuxiu Chen, Hai Jiang, Xiangbo Han, Xia Sun, Zhanli Liu
Novel colorimetric films based on gellan gum (GG) containing red cabbage anthocyanins extract (RCAE) were prepared as pH-freshness smart labels for real-time visual detection of mushroom freshness. The GG/RCAE films had excellent pH and ammonia sensitivity. The GG/RCAE-0.2–0.3 films had the highest sensitivity to acetic acid. The SEM micrographs, AFM images, FT-IR and XRD spectra demonstrated that
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The mechanism of encapsulating curcumin into oleosomes (Lipid Droplets) Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-27 Umay Sevgi Vardar, Johannes H. Bitter, Constantinos V. Nikiforidis
Organisms have evolved intracellular micron-sized lipid droplets to carry and protect lipids and hydrophobic minor compounds in the hydrophilic environment of cells. These droplets can be utilized as carriers of hydrophobic therapeutics by taking advantage of their biological functions. Here, we focus on the potential of plant-derived lipid droplets, known as oleosomes, as carriers for hydrophobic
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Novel silver nanoparticle-antibiotic combinations as promising antibacterial and anti-biofilm candidates against multiple-antibiotic resistant ESKAPE microorganisms Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-25 Maitri Mishra, Anand Ballal, Devashish Rath, Archana Rath
The emergence of Multiple Antibiotic Resistance (MAR) in ESKAPE (, , , , , and spp.) pathogens is a global challenge to public health. The inherent antimicrobial nature of silver nanoparticles (AgNPs) makes them promising antimicrobial candidates against antibiotic-resistant pathogens. This study explores the combination of AgNPs with antibiotics (SACs) to create new antimicrobial agents effective
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Ferrocene-functionalized polydopamine film timely mediates M1-to-M2 macrophage polarization through adaptive wettability Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-25 Ying Shu, Kai Li, Jieping Li, Yi Ding, Guangzhi Yang, Xuebin Zheng
Dynamical control of macrophage polarization from M1 (pro-inflammatory) to M2 (anti-inflammatory) at implant surfaces is essential for balancing innate immunity and tissue repair. In this aspect, the design of orthopedic implant that can response to inflammation microenvironment with transformation in surface properties has shown promising in timely driving M1-to-M2 macrophage transition. Considering
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Machine learning-based exosome profiling of multi-receptor SERS sensors for differentiating adenocarcinoma in situ from early-stage invasive adenocarcinoma Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-24 Dechan Lu, Bohan Zhang, Zhikun Shangguan, Yudong Lu, Jingbo Chen, Zufang Huang
Exosomes, extracellular vesicles released by cells, hold potential as diagnostic markers for the early detection of lung cancer. Despite their clinical promise, current technologies lack rapid and effective means to discriminate between exosomes derived from adenocarcinoma in situ (AIS) and early-stage invasive adenocarcinoma (IAC). This challenge arises from the intrinsic structural heterogeneity
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Biocompatible formulation of a hydrophobic antimicrobial peptide L30 through nanotechnology principles and its potential role in mouse pneumonia model infected with Staphylococcus aureus Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-24 Ruihua Li, Huiping Gao, Ruiling Zhang, Beibei Zhang, Xueqin Wang, Xinhui Zhang, Ruifang Li
Hydrophobic antimicrobial peptide L30, a potential antibiotic candidate, has poor water solubility and hemolytic activity. Herein, a biocompatible nano-formulation composed of liposomes and dendritic mesoporous silica encapsulation (LDMSNs@L30) was constructed for L30 to solve the limits for its clinical development. The characterization, antimicrobial activity and therapeutic effect of LDMSNs@L30
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The investigation on sialic acid-modified pectin nanoparticles loaded with oxymatrine for orally targeting and inhibiting the of ulcerative colitis Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-23 Chunying Zhao, Xin Yang, Mengyao Fan, Linan Tian, Tongtong Sun, Changshan Sun, Tongying Jiang
The aim of the study was to develop an oral targeting drug delivery system (OTDDS) of oxymatrine (OMT) to effectively treat ulcerative colitis (UC). The OTDDS of OMT (OMT/SA-NPs) was constructed with OMT, pectin, Ca, chitosan (CS) and sialic acid (SA). The obtained particles were characterized in terms of particle size, zeta potential, morphology, drug loading, encapsulation efficiency, drug release
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Nanographene-Au fine-tuning to intensify plasmonic-resonance of polymeric hybrid bionanosystem for synergistic phototherapy and nerve photobiomodulation Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-22 Richa Jaswal, Dinesh Kumar, Abdelrahman I. Rezk, Vignesh Krishnamoorthi Kaliannagounder, Chan Hee Park, Kyung Hyun Min
Here, we report the multi-photo-bioactivity of the plasmonic-nano graphitic coordinated polycaprolactone-based aligned nanofibrous scaffolds-based bionanosystem for photothermal breast and colon cancer therapies and peripheral nerve photobiomodulation. The size-optimized colloidal reduced graphene oxide (nRGO, 180nm) nanosheets, for enhanced photothermal impact, were surface-functionalized with gold
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A Cu(Ⅱ)-eluting coating through silk fibroin film on ZE21B alloy designed for in situ endotheliazation biofunction Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-22 Qianying Jia, Qinggong Jia, Shijie Zhu, Yufeng Zheng, Shaokang Guan
In the cardiovascular field, coating containing copper used to catalyze NO (nitric oxide) production on non-degradable metal surfaces have shown unparalleled expected performance, but there are few studies on biodegradable metal surfaces. Magnesium-based biodegradable metals have been applied in cardiovascular field in large-scale because of their excellent properties. In this study, the coating of
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Highly efficient GPCR immobilization with enhanced fouling resistance, salt tolerance, and chromatographic performance Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-22 Sai Qiao, Xinxin Zheng, Yuanyuan Ou, Ting Li, Xue Zhao, Jia Quan, Xinfeng Zhao, Qian Li
The feasibility of immobilized protein-based biodetection relies critically on the activity of the immobilized proteins as well as the biocompatibility of the protein surface. Although many protein immobilization strategies have been developed with satisfied detection readout signals. Non-specific interactions caused by the protein-coating surface are still of great concern since they often interfere
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Dual functionality of diacylglycerols in water-in-oil emulsion gel systems Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-21 Karin Wagner, Maya Davidovich-Pinhas
Distearin (DS) can be used as an emulsifier, due to its surface activity derived from the amphiphilic nature of the molecule, moreover, it can also crystallize and form a 3D crystal network that can induce oil gelation. The current research aimed to examine the ability to combine both emulsifying and oil gelation properties to structure and stabilize water-in-oil emulsion gel system. Different water
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Instability of membranes containing ionizable cationic lipids: Effects of the repulsive range of headgroups and tail structures Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-20 Hao-Chun Huang, Chih-Jung Lin, Yu-Jane Sheng, Heng-Kwong Tsao
The stability of membranes formed by ionizable cationic lipids, which constitute the primary components in lipid nanoparticles capable of endosomal escape, is explored using coarse-grained dissipative particle dynamics. Three types of ionizable model lipids with different tail structures are considered. Endosome acidification causes the ionization of lipids, leading to an increased repulsive range
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Biodegradable and gas barrier polylactic acid/star-shaped polycaprolactone blend films functionalized with a bio-sourced polyelectrolyte coating Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-20 Luca Valle, Lorenza Maddalena, Giacomo Damonte, Federico Carosio, Alessandro Pellis, Orietta Monticelli
This work aims at improving and disclosing new properties of films based on polylactic acid (PLA) and a star-shaped polycaprolactone (PCL). Indeed, previous works demonstrated that the presence of synthesized PCL, characterized by low molecular weight and carboxyl end groups (coded as PCL-COOH), improves the elongation at break of the films compared to that of neat PLA and increases their functionality
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Cu-MSNs and ZnO nanoparticles incorporated poly(ethylene glycol) diacrylate/sodium alginate double network hydrogel for simultaneous enhancement of osteogenic differentiation Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-17 Esensil Man Hia, Se Rim Jang, Bikendra Maharjan, Jeesoo Park, Chan Hee Park
In this study, a double network (DN) hydrogel was synthesized using poly(ethylene glycol) diacrylate (PEGDA) and sodium alginate (SA), incorporating copper-doped mesoporous silica nanospheres (Cu-MSNs) and zinc oxide nanoparticles (ZnO NPs). The blending of PEGDA and SA (PS) facilitates the double network and improves the less porous microstructure of pure PEGDA hydrogel. Furthermore, the incorporation
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Enhancing immune modulation and bone regeneration on titanium implants by alleviating the hypoxic microenvironment and releasing bioactive ions Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-17 Dongdong Zhang, Han Liu, Xiaodong Xue, Feihong Liu, Jun Wu, Feng Peng, Donghui Wang, Haobo Pan, Mei Li
Bone implantation inevitably causes damage to surrounding vasculature, resulting in a hypoxic microenvironment that hinders bone regeneration. Although titanium (Ti)-based devices are widely used as bone implants, their inherent bioinert surface leads to poor osteointegration. Herein, a strontium peroxide (SrO)-decorated Ti implant, Ti_P@SrO, was constructed through coating with poly-L-lactic acid
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Thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of EGF to inhibit cervical cancer recurrence Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-16 Li Piao, Peng Xiang, Yangyang Zhou, Wei Zhao, Ting Yang, Shan Xia, Guanghui Gao, Kexin Chen, Dan Li
Overexpression of epidermal growth factor receptor (EGFR) in cancer is a key cause of recurrence of cervical cancer (CC). Although the EGF-EGFR pathway has been studied for decades, preventing tumor growth and recurrence caused by peripheral EGF remains a great challenge. In this work, a strategy is proposed to reduce the stimulation of high concentration EGF on tumor growth by using a thermo-sensitive
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Novel polyurethane-based ionene nanoparticles electrostatically stabilized with hyaluronic acid for effective gene therapy Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-16 Athar Mahdieh, Hamidreza Motasadizadeh, Samane Maghsoudian, Alireza Sabzevari, Fereshte Khalili, Hamid Yeganeh, Bo Nyström
Gene therapy is considered to be a valuable strategy for effective cancer treatment. However, the development of effective delivery systems that can specifically deliver gene materials, such as siRNA to tumor tissues plays a critical role in cancer therapy. In the present study, we have developed a novel complex that is based on an electrostatic interaction between cationic polyurethane ionene (CPUI)
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Swelling and penetration of fatty acid vesicles under ion-competitive environment Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-15 Lichun Chen, Yun Huang, Huimin Zhao, Songwen Xue
The physicochemical characteristics of fatty acid (FA) vesicles and their ion sensitivity as drug delivery vehicles in an ion-competitive environment have received much attention. Here, we show that in a Na/K competitive ionic environment, FA vesicles undergo a cascade of periodic expansion and selective ion retention in response to osmotic attack. When the Na/K ratio is altered, the expansion and
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Modulation of the dissolution with ASP from a supersaturated solution on a bionic platform for gout pathology crystals Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-15 Yonghai Liu, Pengfei Zhang, Peiyun Lei, Yige Jin, Haoting Yu, Xingde Zhang, Yonglan Pan, Chunyan Ou, Tingming Fu
The core to the treatment of gout is the elimination of pathologic crystal, monosodium urate monohydrate (MSUM). The primary treatment available is to gradually dissolve the “culprit crystals” by lowering the blood uric acid concentration with medications, which often takes a long time and in severe cases must still be treated surgically. Herein, we developed a dynamic bionic platform based on a hydrogel
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Transition from active motion to anomalous diffusion for Bacillus subtilis confined in hydrogel matrices Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-15 Gavino Bassu, Marco Laurati, Emiliano Fratini
We investigate the motility of under different degrees of confinement induced by transparent porous hydrogels. The dynamical behavior of the bacteria at short times is linked to characteristic parameters describing the hydrogel porosity. Mean squared displacements (MSDs) reveal that the run-and-tumble dynamics of unconfined progressively turns into sub-diffusive motion with increasing confinement.
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Preparation and sustained-release mechanism of hydroxybutyl chitosan/graphene oxide temperature-sensitive hypoglycaemic subcutaneous implants Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-14 Li Li, Fengting Xiang, Fan Wang, Anqi Chen, Yu Liu
The current situation of diabetes prevention and control is extremely severe. For instance, glimepiride (GLM), a third-generation sulfonylurea, demonstrates suboptimal clinical efficacy in oral dosage forms, which underscores the pressing need for the development of a new dosage form. Recently, gel subcutaneous implants have garnered considerable attention. Hydroxybutyl chitosan (HBC) can spontaneously
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Telmisartan loading thermosensitive hydrogel repairs gut epithelial barrier for alleviating inflammatory bowel disease Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-14 Lu Xu, Qin Zhao, Yiqiong Xie, Ge Bai, Hongwen Liu, Qi Chen, Hongjue Duan, Lishan Wang, Hang Xu, Yuxiang Sun, Gao Ling, Weihong Ge, Yun Zhu
Inflammatory bowel disease (IBD) remains a global health concern with a complex and incompletely understood pathogenesis. In the course of IBD development, damage to intestinal epithelial cells and a reduction in the expression of tight junction (TJ) proteins compromise the integrity of the intestinal barrier, exacerbating inflammation. Notably, the renin-angiotensin system and angiotensin II receptor
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Purification-free synthesis of bright lactoglobulin@dye nanoprobe for second near-infrared fluorescence imaging of kidney dysfunction in vivo Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-12 Xinyu Feng, Guohe Wang, Jinbin Pan, Xu Wang, Junping Wang, Shao-Kai Sun
Kidney disease is currently prevalent worldwide but only shows insidious symptoms in the early stages. The second near-infrared window (NIR-II) fluorescence imaging has become a widely used preclinical technology for evaluating renal dysfunction due to its high resolution and sensitivity. However, bright renal clearable NIR-II fluorescence nanoprobes with a simple synthesis process are still lacking
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Tauroursodeoxycholic acid liposome alleviates DSS-induced ulcerative colitis through restoring intestinal barrier and gut microbiota Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-12 Junke Zhao, Suqi Hao, Yan Chen, Xiaoxing Ye, Pengchao Fang, Haiyan Hu
Ulcerative colitis (UC) is a chronic and progressive inflammatory disease that damages the colonic mucosa and disrupts the intestinal epithelial barrier. The current clinical treatment for UC is mainly chemotherapy, which has the limited effectiveness and severe side effects. It mainly focuses on the treatment of inflammation while neglecting the repair of the intestinal mucosa and the restoration
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Selective inhibition of partial EMT-induced tumour cell growth by cerium valence states of extracellular ceria nanoparticles for anticancer treatment Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-10 Tamaki Naganuma
Targeting specific tumour cells and their microenvironments is essential for enhancing the efficacy of chemotherapy and reducing its side effects. A partial epithelial-to-mesenchymal transition state (pEMT, with a hybrid epithelial/mesenchymal phenotype) in tumour cells is an attractive targeting for anticancer treatment because it potentially provides maximal stemness and metastasis relevant to malignant
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Impact of UV radiation on Mxene-mediated tubulin dissociation and mitochondrial apoptosis in breast cancer cells Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-09 Ee Wern Tan, Samson Eugin Simon, Arshid Numan, Mohammad Khalid, Kuan Onn Tan
Breast cancer is a global health concern that requires personalized therapies to prevent relapses, as conventional treatments may develop resistance over time. Photothermal therapy using spectral radiation or intense light emission is a broad-spectrum treatment that induces hyperthermia-mediated cancer cell death. MXene, a two-dimensional material, has been reported to have potential biological applications
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AIE luminogen labeled polymeric micelles for biological imaging and chemotherapy Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-07 Na Liang, Yingxue Xu, Wei Zhao, Zhenrong Liu, Gang Li, Shaoping Sun
In this study, an amphiphilic polymer FA-CS-DBA-CHO with aggregation-induced emission (AIE) feature was prepared by introducing 4-(diphenylamino)benzaldehyde derivative (DBA-CHO), imine bond and folic acid (FA) to the molecular structure of chitosan (CS). The amphiphilicity drove the polymer to self-assemble into micelles, and paclitaxel (PTX) could be solubilized in the hydrophobic core. Due to the
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Injectable biocompatible RAFT mediated nitroxide nanogels: A robust ROS-reduction antioxidant approach Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-07 Suman Basak, Ishita Mukherjee, Tushar Kanti Das
This work introduces novel nitroxide-based nanogels (NGs) crafted through controlled RAFT (Reversible Addition Fragmentation chain Transfer) polymerization, showcasing over 85% improved shelf-life compared to native superoxide dismutase (SOD) enzymes. These 30–40 nm NGs hold great promise for injectable delivery, effectively reducing foam cell formation and displaying potent antioxidant behavior against
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Tannic acid- and N-acetylcysteine-chitosan-modified magnetic nanoparticles reduce hepatic oxidative stress in prediabetic rats Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-07 Małgorzata Świętek, Irena Marková, Hana Malínská, Martina Hüttl, Denisa Miklánková, Kristýna Černá, Rafał Konefał, Daniel Horák
Magnetic nanoparticles (MNPs) modified with tannic acid (TA) have shown remarkable success as an antioxidant and antimicrobial therapeutic agent. Herein, we report a synthetic procedure for the preparation of silica-coated MNPs modified with -acetylcysteine-modified chitosan and TA. This was achieved by free-radical grafting of NAC onto chitosan (CS), a layer-by-layer technique for modifying negatively
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Specific anion effects on urease activity: A Hofmeister study Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-06 Mert Acar, Duccio Tatini, Marcello A. Budroni, Barry W. Ninham, Mauro Rustici, Federico Rossi, Pierandrea Lo Nostro
The effects of a range of electrolytes on the hydrolysis of urea by the enzyme urease is explored. The autocatalytic behavior of urease in unbuffered solutions and its pH clock reactions are studied. The concentration dependence of the experimental variables is analyzed in terms of specific ion-enzyme interactions and hydration. The results offer insights into the molecular mechanisms of the enzyme
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Tripeptides Ghk and GhkCu-modified silver nanoparticles for enhanced antibacterial and wound healing activities Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-05 Rehmat Islam, Hazrat Bilal, Xuejing Wang, Lianbing Zhang
Bacterial skin infections represent a major healthcare concern that can delay healing and threaten human health. Silver nanoparticles (AgNPs) have been widely used for antimicrobial purposes; however, their high toxicity limits their applications. Therefore, there is an urgent need to develop simple and efficient therapeutic approaches for treating bacterial infections and promoting wound healing.
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Low temperature synthesis of chiral carbon dots for reducing H2O2 damage Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-05 Beibei Wang, Yuying Wang, Xiaoyang Zhang, Yi Liu
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Dentin surface modification by MDP to improve dentin bonding stability: Topological enhancement and mineralization of collagen structure in hybrid layers Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-05 Ying Shi, Haiyan Zheng, Wenting Wang, Linna Qian, Weijia Zhao, Jingqiu Xu, Mingxing Li, Zhifang Wu, Baiping Fu
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Diversely substituted poly(N-vinyl amide) derivatives towards non-toxic, stealth and pH-responsive lipid nanocapsules Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-05 François Toussaint, Elise Lepeltier, Florence Franconi, Vincent Pautu, Christine Jérôme, Catherine Passirani, Antoine Debuigne
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Development, characterization, and evaluation of the antioxidant activity of nanocarriers based on surfactant swollen micelles that encapsulate essential oils Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-03 Agustina Delmonte, Flavia F. Visentini, José L. Fernández, Liliana G. Santiago, Adrián A. Perez
This work aimed to compare the performance of two relatively underexplored methods for the swollen micelles (SMs) production as nanocarriers for essential oils (EOs). and EOs were examined. The first method (SMs-1), involved a self-assembly process, while the second one (SMs-2), employed titration operation of an emulsion into a surfactant solution for SMs formation. Tween 80 and ethanol were used
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Human dental pulp stem cell-derived exosomes decorated titanium scaffolds for promoting bone regeneration Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-03 Siqi Zhang, Simeng Wang, Jun Chen, Yifan Cui, Xugang Lu, Shibing Xiong, Chongxia Yue, Bangcheng Yang
Exosomes, nanoscale extracellular vesicles crucial for intercellular communication, hold great promise as a therapeutic avenue in cell-free tissue regeneration. In this study, we identified and utilized exosomes to adorn anodized titanium scaffolds, inducing osteogenic differentiation in human dental pulp stem cells (hDPSCs). The osteogenesis of hDPSCs was stimulated by exosomes derived from hDPSCs
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Engineered macrophage-derived cellular vesicles for NIR-II fluorescence imaging-guided precise cancer photo-immunotherapy Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-02 Quanshi Lin, Yichao Wang, Linlin Wang, Zhijin Fan
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Visual detection of H2O2 and glucose by HBcAb-HRP fluorescence-enhanced CdTe QDs/CDs ratiometric fluorescence sensing platform Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-02 Jie Cao, Han Jiang, Yiwei Wu, Xiaoxiao Yu
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Invitro anti-biofilm activity and the artificial chaperone activity of quinoline-based ionic liquids Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-02-01 Kajal Sharma, Meenakshi Sharma
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Coaxial nanofibers encapsulated with Ampelopsis brevipedunculata extract and green synthesized AgNPs for wound repair Colloids Surf. B Biointerfaces (IF 5.8) Pub Date : 2024-01-29 Te-Yang Huang, Jr-Ying Lin, Wen-Ta Su
Silver nanoparticles (AgNPs) synthesized from Aloe vera extract exhibited a pronounced antibacterial effect, while the Ampelopsis brevipedunculata extract (ABE) showcased a high antioxidant capacity for wound healing. Spherical AgNPs with a particle size of 28.82 nm crystallized in a face-centered-cubic lattice. AgNPs/polyvinyl alcohol (PVA) and ABE/polycaprolactone (PCL) underwent electrospinning