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Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors Regen. Biomater. (IF 4.882) Pub Date : 2020-12-15 Gao C, Qiu Z, Hou J, et al.
AbstractCurettage of benign bone tumor is a common cause for bone defect. For such bone defect repair, autogenous bone, allogeneic bone and traditional artificial bone graft substitutes have many disadvantages. In recent years, a biomimetic mineralized collagen (MC) with similar composition and microstructures to the natural bone matrix was developed and used for treating various bone defects. In this
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Detection of Type I and III collagen in porcine acellular matrix using HPLC–MS Regen. Biomater. (IF 4.882) Pub Date : 2020-10-01 Zhang Y, Chen Y, Zhao B, et al.
AbstractAcellular matrix (ACM) has been widely used as a biomaterial. As the main component of ACM, collagen type and content show influence on the material properties. In this research, the collagen in ACM from different tissues of pig were determined by detection of marker peptides. The marker peptides of Type I and III collagen were identified from the digested collagen standards using ions trap
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Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration Regen. Biomater. (IF 4.882) Pub Date : 2020-09-30 Fu L, Yang Z, Gao C, et al.
AbstractDue to the sophisticated hierarchical structure and limited reparability of articular cartilage (AC), the ideal regeneration of AC defects has been a major challenge in the field of regenerative medicine. As defects progress, they often extend from the cartilage layer to the subchondral bone and ultimately lead to osteoarthritis. Tissue engineering techniques bring new hope for AC regeneration
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Integrated transcriptomic and proteomic study on the different molecular mechanisms of PC12 cell growth on chitosan and collagen/chitosan films Regen. Biomater. (IF 4.882) Pub Date : 2020-08-31 Lü X, Huang Y, Qu Y, et al.
AbstractThe purpose of this article is to integrate the transcriptomic analysis and the proteomic profiles and to reveal and compare the different molecular mechanisms of PC12 cell growth on the surface of chitosan films and collagen/chitosan films. First, the chitosan films and the collagen/chitosan films were prepared. Subsequently, the cell viability assay was performed; the cell viability of the
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Utility of direct 3D co-culture model for chondrogenic differentiation of mesenchymal stem cells on hyaluronan scaffold (Hyaff-11) Regen. Biomater. (IF 4.882) Pub Date : 2020-08-23 Deszcz I, Lis-Nawara A, Grelewski P, et al.
AbstractThis study presents direct 2D and 3D co-culture model of mesenchymal stem cells (MSCs) line with chondrocytes isolated from patients with osteoarthritis (unaffected area). MSCs differentiation into chondrocytes after 14, 17 days was checked by estimation of collagen I, II, X, aggrecan expression using immunohistochemistry. Visualization, localization of cells on Hyaff-11 was performed using
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Preclinical study of a self-expanding pulmonary valve for the treatment of pulmonary valve disease Regen. Biomater. (IF 4.882) Pub Date : 2020-08-22 Kuang D, Lei Y, Yang L, et al.
AbstractIn the past decade, balloon-expandable percutaneous pulmonary valves have been developed and applied in clinical practice. However, all the existing products of pulmonary artery interventional valves in the market have a straight structure design, and they require a preset support frame and balloon expansion. This shape design of the valve limits the application range. In addition, the age
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Effect of different aged cartilage ECM on chondrogenesis of BMSCs in vitro and in vivo Regen. Biomater. (IF 4.882) Pub Date : 2020-08-04 Wang X, Lu Y, Wang W, et al.
AbstractExtracellular matrix (ECM)-based biomaterials are promising candidates in cartilage tissue engineering by simulating the native microenvironment to regulate the chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) without exogenous growth factors. The biological properties of ECM scaffolds are primarily depended on the original source, which would directly influence the
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Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants Regen. Biomater. (IF 4.882) Pub Date : 2020-09-06 Li P, Cai W, Li X, et al.
AbstractPolyurethanes are widely used in interventional devices due to the excellent physicochemical property. However, non-specific adhesion and severe inflammatory response of ordinary polyurethanes may lead to severe complications of intravenous devices. Herein, a novel phospholipid-based polycarbonate urethanes (PCUs) were developed via two-step solution polymerization by direct synthesis based
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A novel antibacterial biomaterial mesh coated by chitosan and tigecycline for pelvic floor repair and its biological performance Regen. Biomater. (IF 4.882) Pub Date : 2020-09-02 Liang C, Ling Y, Wei F, et al.
AbstractThe biomaterials composed of mammalian extracellular matrix (ECM) have a great potential in pelvic floor tissue repair and functional reconstruction. However, bacterial infection does cause great damage to the repair function of biomaterials which is the major problem in clinical utilization. Therefore, the development of biological materials with antimicrobial effect is of great clinical significance
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Improved the biocompatibility of cancellous bone with compound physicochemical decellularization process Regen. Biomater. (IF 4.882) Pub Date : 2020-08-30 Ling Y, Xu W, Yang L, et al.
AbstractDue to the unique microstructures and components of extracellular matrix (ECM), decellularized scaffolds had been used widely in clinical. The reaction of the host toward decellularized scaffolds depends on their biocompatibility, which should be satisfied before applied in clinical. The aim of this study is to develop a decellularized xenograft material with good biocompatibility for further
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Au, Pd and maghemite nanofunctionalized hydroxyapatite scaffolds for bone regeneration Regen. Biomater. (IF 4.882) Pub Date : 2020-08-27 Calabrese G, Petralia S, Fabbi C, et al.
AbstractNanotechnology plays a key role in the development of innovative scaffolds for bone tissue engineering (BTE) allowing the incorporation of nanomaterials able to improve cell proliferation and differentiation. In this study, Mg-HA-Coll type I scaffolds (Mg-HA-based scaffolds) were nanofunctionalized with gold nanorods (Au NRs), palladium nanoparticles (Pd NPs) and maghemite nanoparticles (MAG
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Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture Regen. Biomater. (IF 4.882) Pub Date : 2020-08-18 Malcor J, Hunter E, Davidenko N, et al.
AbstractPorous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue repair. Collagen biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered tissues. Three-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness
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Porous silicon carbide coated with tantalum as potential material for bone implants Regen. Biomater. (IF 4.882) Pub Date : 2020-06-18 Ma Z, Li J, Cao F, et al.
AbstractPorous silicon carbide (SiC) has a specific biomorphous microstructure similar to the trabecular microstructure of human bone. Compared with that of bioactive ceramics, such as calcium phosphate, SiC does not induce spontaneous interface bonding to living bone. In this study, bioactive tantalum (Ta) metal deposited on porous SiC scaffolds by chemical vapour deposition was investigated to accelerate
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Zn-contained mussel-inspired film on Mg alloy for inhibiting bacterial infection and promoting bone regeneration Regen. Biomater. (IF 4.882) Pub Date : 2020-09-30 Feng Peng; Shi Cheng; Ruiying Zhang; Mei Li; Jielong Zhou; Donghui Wang; Yu Zhang
Infection and insufficient osteointegration are the main causes of orthopedic implant failure. Furthermore, activating favorable inflammation response is vital to the fast osteointegration of implants. Therefore, endowing the implants with multifunctions (antibacterial, anti-inflammation, and pro-osteointegration) is a promising strategy to improve the performance of orthopedic implants. In this study
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A comparative study of autogenous, allograft and artificial bone substitutes on bone regeneration and immunotoxicity in rat femur defect model Regen. Biomater. (IF 4.882) Pub Date : 2020-09-30 Wen Zou; Xing Li; Na Li; Tianwei Guo; Yongfu Cai; Xiaoqin Yang; Jie Liang; Yong Sun; Yujiang Fan
Repair and reconstruction of large bone defect were often difficult, and bone substitute materials, including autogenous bone, allogenic bone and artificial bone, were common treatment strategies. The key to elucidate the clinical effect of these bone repair materials was to study their osteogenic capacity and immunotoxicological compatibility. In this paper, the mechanical properties, micro-CT imaging
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Corrigendum to: Hierarchically electrospraying a PLGA@chitosan sphere-in-sphere composite microsphere for multi-drug-controlled release. Regen. Biomater. (IF 4.882) Pub Date : 2020-08-08 Zhu Liu,Weilong Ye,Jingchuan Zheng,Qindong Wang,Guowu Ma,Huiying Liu,Xiumei Wang
doi: 10.1093/rb/rbaa009, Regenerative Biomaterials 2020;381–390
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High-drug-loading capacity of redox-activated biodegradable nanoplatform for active targeted delivery of chemotherapeutic drugs. Regen. Biomater. (IF 4.882) Pub Date : 2020-07-06 Hai Zhang,Jianqin Yan,Heng Mei,Shengsheng Cai,Sai Li,Furong Cheng,Jun Cao,Bin He
Challenges associated with low-drug-loading capacity, lack of active targeting of tumor cells and unspecific drug release of nanocarriers synchronously plague the success of cancer therapy. Herein, we constructed active-targeting, redox-activated polymeric micelles (HPGssML) self-assembled aptamer-decorated, amphiphilic biodegradable poly (benzyl malolactonate-co-ε-caprolactone) copolymer with disulfide
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Immune risk assessment of residual αGal in xenogeneic decellularized cornea using GTKO mice. Regen. Biomater. (IF 4.882) Pub Date : 2020-06-23 Liang Chen,Lina Wei,Anliang Shao,Liming Xu
The xenogeneic decellularized corneal matrix (DCM) was expected to be used in lamellar keratoplasty in clinic as the substitute of allogeneic cornea. After decellularization treatment, the remaining risk of xenograft rejection needed to be assessed. The galactose-α1,3-galactose, as the most abundant and closely rejection-related xenogeneic antigen, should be one of the important factors concerned in
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Enhancement of BMP-2 and VEGF carried by mineralized collagen for mandibular bone regeneration. Regen. Biomater. (IF 4.882) Pub Date : 2020-06-13 Kun Liu,Chun-Xiu Meng,Zhao-Yong Lv,Yu-Jue Zhang,Jun Li,Ke-Yi Li,Feng-Zhen Liu,Bin Zhang,Fu-Zhai Cui
Repairing damage in the craniofacial skeleton is challenging. Craniofacial bones require intramembranous ossification to generate tissue-engineered bone grafts via angiogenesis and osteogenesis. Here, we designed a mineralized collagen delivery system for BMP-2 and vascular endothelial growth factor (VEGF) for implantation into animal models of mandibular defects. BMP-2/VEGF were mixed with mineralized
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Corrigendum to: Corrosion behavior and cytocompatibility of fluoride-incorporated plasma electrolytic oxidation coating on biodegradable AZ31 alloy. Regen. Biomater. (IF 4.882) Pub Date : 2020-06-03 Peng Tian,Feng Peng,Donghui Wang,Xuanyong Liu
doi: 10.1093/rb/rbw036, Regenerative Biomaterials 2017;4:1–10
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Cell-derived biomimetic nanoparticles as a novel drug delivery system for atherosclerosis: predecessors and perspectives. Regen. Biomater. (IF 4.882) Pub Date : 2020-05-25 Long Yang,Guangchao Zang,Jingwen Li,Xinyue Li,Yuanzhu Li,Yinping Zhao
Atherosclerosis is a key mechanism underlying the pathogenesis of cardiovascular disease, which is associated with high morbidity and mortality. In the field of precision medicine for the treatment of atherosclerosis, nanoparticle (NP)-mediated drug delivery systems have great potential, owing to their ability to release treatment locally. Cell-derived biomimetic NPs have attracted extensive attention
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Surface modification of small intestine submucosa in tissue engineering. Regen. Biomater. (IF 4.882) Pub Date : 2020-05-18 Pan Zhao,Xiang Li,Qin Fang,Fanglin Wang,Qiang Ao,Xiaohong Wang,Xiaohong Tian,Hao Tong,Shuling Bai,Jun Fan
With the development of tissue engineering, the required biomaterials need to have the ability to promote cell adhesion and proliferation in vitro and in vivo. Especially, surface modification of the scaffold material has a great influence on biocompatibility and functionality of materials. The small intestine submucosa (SIS) is an extracellular matrix isolated from the submucosal layer of porcine
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Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration. Regen. Biomater. (IF 4.882) Pub Date : 2020-05-09 Yajuan Xie,Cheng Hu,Yi Feng,Danfeng Li,Tingting Ai,Yulei Huang,Xiaodan Chen,Lijia Huang,Jiali Tan
Biomaterials as bone substitutes are always considered as foreign bodies that can trigger host immune responses. Traditional designing principles have been always aimed at minimizing the immune reactions by fabricating inert biomaterials. However, clinical evidence revealed that those methods still have limitations and many of which were only feasible in the laboratory. Currently, osteoimmunology,
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Investigating materials and orientation parameters for the creation of a 3D musculoskeletal interface co-culture model. Regen. Biomater. (IF 4.882) Pub Date : 2020-05-01 Hamad Alsaykhan,Jennifer Z Paxton
Musculoskeletal tissue interfaces are a common site of injury in the young, active populations. In particular, the interface between the musculoskeletal tissues of tendon and bone is often injured and to date, no single treatment has been able to restore the form and function of damaged tissue at the bone–tendon interface. Tissue engineering and regeneration hold great promise for the manufacture of
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A novel method for evaluating the dynamic biocompatibility of degradable biomaterials based on real-time cell analysis. Regen. Biomater. (IF 4.882) Pub Date : 2020-05-01 Xiaoxiao Gai,Chenghu Liu,Guowei Wang,Yang Qin,Chunguang Fan,Jia Liu,Yanping Shi
Degradable biomaterials have emerged as a promising type of medical materials because of their unique advantages of biocompatibility, biodegradability and biosafety. Owing to their bioabsorbable and biocompatible properties, magnesium-based biomaterials are considered as ideal degradable medical implants. However, the rapid corrosion of magnesium-based materials not only limits their clinical application
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Cell-derived extracellular matrix-coated silk fibroin scaffold for cardiogenesis of brown adipose stem cells through modulation of TGF-β pathway. Regen. Biomater. (IF 4.882) Pub Date : 2020-04-24 Wei Liu,Yanfeng Sun,Xiaohui Dong,Qi Yin,Huimin Zhu,Siwei Li,Jin Zhou,Changyong Wang
The cell-derived extracellular matrix (ECM)-modified scaffolds have advantages of mimic tissue specificity and been thought to better mimic the native cellular microenvironment in vitro. ECM derived from cardiac fibroblasts (CFs) are considered as key elements that provide a natural cell growth microenvironment and change the fate of cardiomyocytes (CMs). Here, a new hybrid scaffold is designed based
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In vitro immunomodulation of magnesium on monocytic cell toward anti-inflammatory macrophages. Regen. Biomater. (IF 4.882) Pub Date : 2020-04-14 Lei Sun,Xiaoyu Li,Menghan Xu,Fenghe Yang,Wei Wang,Xufeng Niu
Biodegradable magnesium (Mg) has shown great potential advantages over current bone fixation devices and vascular scaffold technologies; however, there are few reports on the immunomodulation of corrosive Mg products, the micron-sized Mg particles (MgMPs). Human monocytic leukemia cell line THP-1 was set as the in vitro cell model to estimate the immunomodulation of MgMPs on cell proliferation, apoptosis
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Hierarchically electrospraying a PLGA@chitosan sphere-in-sphere composite microsphere for multi-drug-controlled release. Regen. Biomater. (IF 4.882) Pub Date : 2020-04-14 Zhu Liu,Weilong Ye,Jingchuan Zheng,Qindong Wang,Guowu Ma,Huiying Liu,Xiumei Wang
Sequential administration and controlled release of different drugs are of vital importance for regulating cellular behaviors and tissue regeneration, which usually demands appropriate carriers like microspheres (MS) to control drugs releases. Electrospray has been proven an effective technique to prepare MS with uniform particle size and high drug-loading rate. In this study, we applied electrospray
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Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions. Regen. Biomater. (IF 4.882) Pub Date : 2020-04-07 Marley J Dewey,Eileen M Johnson,Simona T Slater,Derek J Milner,Matthew B Wheeler,Brendan A C Harley
Defects in craniofacial bones occur congenitally, after high-energy impacts, and during the course of treatment for stroke and cancer. These injuries are difficult to heal due to the overwhelming size of the injury area and the inflammatory environment surrounding the injury. Significant inflammatory response after injury may greatly inhibit regenerative healing. We have developed mineralized collagen
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Efficacy of concentrated growth factors combined with mineralized collagen on quality of life and bone reconstruction of guided bone regeneration. Regen. Biomater. (IF 4.882) Pub Date : 2020-04-06 Yan Dai,Xiao-Hui Han,Li-Hua Hu,Hai-Wei Wu,Sheng-Yun Huang,Yu-Peng Lü
To evaluate the clinical efficacy of concentrated growth factors (CGFs) combined with mineralized collagen (MC) in guided bone regeneration (GBR). A retrospective study involving 29 patients treated with GBR technique, which was performed either CGF and MC complexes or MC alone. Implants were inserted simultaneously and cone-beam computed tomography was taken immediately, at 3 and 6 months postoperation
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Characterization and biological evaluation of a novel silver nanoparticle-loaded collagen-chitosan dressing. Regen. Biomater. (IF 4.882) Pub Date : 2020-03-30 Rongfu Li,Zhaorong Xu,Qiong Jiang,Yunquan Zheng,Zhaohong Chen,Xiaodong Chen
Effective coverage and protection is a priority in wound treatment. Collagen and chitosan have been widely used for wound dressings due to their excellent biological activity and biocompatibility. Silver nanoparticles (AgNPs) have a powerful antibacterial effect. In this study, a macromolecular and small-molecular collagen mixed solution, a macromolecular and small-molecular chitosan mixed solution
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Sodium alendronate loaded poly(l-lactide- co-glycolide) microparticles immobilized on ceramic scaffolds for local treatment of bone defects. Regen. Biomater. (IF 4.882) Pub Date : 2020-03-30 Łucja Rumian,Cornelia Wolf-Brandstetter,Sina Rößler,Katarzyna Reczyńska,Hanna Tiainen,Håvard J Haugen,Dieter Scharnweber,Elżbieta Pamuła
Bone tissue regeneration in critical-size defects is possible after implantation of a 3D scaffold and can be additionally enhanced once the scaffold is enriched with drugs or other factors supporting bone remodelling and healing. Sodium alendronate (Aln), a widely used anti-osteoporosis drug, exhibits strong inhibitory effect on bone resorption performed by osteoclasts. Thus, we propose a new approach
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Strontium-substituted sub-micron bioactive glasses inhibit ostoclastogenesis through suppression of RANKL-induced signaling pathway. Regen. Biomater. (IF 4.882) Pub Date : 2020-03-30 Deqiu Huang,Fujian Zhao,Wendong Gao,Xiaofeng Chen,Zhouyi Guo,Wen Zhang
Strontium-substituted bioactive glass (Sr-BG) has shown superior performance in bone regeneration. Sr-BG-induced osteogenesis has been extensively studied; however, Sr-BG-mediated osteoclastogenesis and the underlying molecular mechanism remain unclear. It is recognized that the balance of osteogenesis and osteoclastogenesis is closely related to bone repair, and the receptor activators of nuclear
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Remineralization of enamel caries by an amelogenin-derived peptide and fluoride in vitro. Regen. Biomater. (IF 4.882) Pub Date : 2020-03-03 Longjiang Ding,Sili Han,Kun Wang,Sainan Zheng,Wenyue Zheng,Xiu Peng,Yumei Niu,Wei Li,Linglin Zhang
Dental caries is one of the most common oral diseases in the world. This study was tantamount to investigate the combinatory effects of an amelogenin-derived peptide (called QP5) and fluoride on the remineralization of artificial enamel caries. The peptide QP5 was synthesized and characterized, and the binding capability of the peptide on hydroxyapatite (HA) and demineralized tooth enamel surface was
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A tarsus construct of a novel branched polyethylene with good elasticity for eyelid reconstruction in vivo. Regen. Biomater. (IF 4.882) Pub Date : 2020-02-07 Peifang Xu,Xue Feng,Honghao Zheng,Zhongwei Feng,Zhisheng Fu,Changyou Gao,Juan Ye
Branched polyethylene (B-PE) elastomer was investigated for its potential medical application as a tarsus construct. The in vitro results showed that the B-PE and processed B-PE films or scaffolds did not exhibit noticeable cytotoxicity to the NIH3T3 fibroblasts and human vascular endothelial cells (ECs). The B-PE scaffolds with a pore size of 280–480 µm were prepared by using a gelatin porogen-leaching
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Study on repairing canine mandibular defect with porous Mg-Sr alloy combined with Mg-Sr alloy membrane. Regen. Biomater. (IF 4.882) Pub Date : 2020-01-30 Shanning Zhang,Xirao Sun,Chunyu Kang,Man Yang,Yuan Zhao,Chengyue Wang
To discuss the feasibility of the application of porous Mg–Sr alloy combined with Mg–Sr alloy membrane in the repair of mandibular defects in dogs. The second and third mandibular premolars on both sides were extracted from six dogs. The model of mandible buccal fenestration bone defects were prepared after the sockets healed. Twelve bone defects were randomly divided into groups A and B, then Mg–Sr
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Comparative study of the effects of gold and silver nanoparticles on the metabolism of human dermal fibroblasts. Regen. Biomater. (IF 4.882) Pub Date : 2020-01-25 Yan Huang,Xiaoying Lü,Rong Chen,Ye Chen
The purpose of this article was to explore the effects of gold nanoparticles (GNPs) and silver nanoparticles (SNPs) with different cytotoxicities on human dermal fibroblasts (HDFs) at the metabolic level. First, ∼20 nm of GNPs and SNPs were prepared, and their effects on the proliferation of HDFs were evaluated. Then, a metabolomics technique was used to analyse the effects of GNPs and SNPs on the
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Candida albicans aspects of binary titanium alloys for biomedical applications. Regen. Biomater. (IF 4.882) Pub Date : 2020-01-25 Shuyang Chen,James K H Tsoi,Peter C S Tsang,Yeong-Joon Park,Ho-Jun Song,Jukka P Matinlinna
Titanium and its alloys are widely used in biomedical devices, e.g. implants, due to its biocompatibility and osseointegration ability. In fact, fungal (Candida spp.) infection has been identified as one of the key reasons causing the failure of the device that is inevitable and impactful to the society. Thus, this study evaluated the surface morphology, surface chemical composition and Candida albicans
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The observed difference of macrophage phenotype on different surface roughness of mineralized collagen. Regen. Biomater. (IF 4.882) Pub Date : 2020-01-25 Jun Li,Yu-Jue Zhang,Zhao-Yong Lv,Kun Liu,Chun-Xiu Meng,Bo Zou,Ke-Yi Li,Feng-Zhen Liu,Bin Zhang
Biomaterials regulate macrophages and promote regeneration function, which is a new hot pot in tissue engineering and regenerative medicine. The research based on macrophage materials biology has appeared happy future, but related research on regulating macrophages and promoting tissue regeneration is still in its infancy. The surface roughness of biomaterials is one of the important factors affecting
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Cu∥-loaded polydopamine coatings with in situ nitric oxide generation function for improved hemocompatibility. Regen. Biomater. (IF 4.882) Pub Date : 2020-01-17 Lei Zhou,Xin Li,Kebing Wang,Fangyu Shen,Lu Zhang,Peichuang Li,Tengda Shang,Jin Wang,Nan Huang
NO is the earliest discovered gas signal molecule which is produced by normal healthy endothelial cells, and it has many functions, such as maintaining cardiovascular homeostasis, regulating vasodilation, inhibiting intimal hyperplasia and preventing atherosclerosis in the blood system. Insufficient NO release is often observed in the pathological environment, for instance atherosclerosis. It was discovered
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Human adipose-derived mesenchymal stem cells accelerate decellularized neobladder regeneration. Regen. Biomater. (IF 4.882) Pub Date : 2019-12-22 Victoria Moreno-Manzano,Maravillas Mellado-López,Maria Jose Morera-Esteve,Ana Alastrue-Agudo,Viviana Bisbal-Velasco,Jerónimo Forteza-Vila,Ángel Serrano-Aroca,César David Vera-Donoso
Decellularized natural bladder matrices (neobladders) represent an exciting means to regenerate the bladder following bladder cancer-associated cystectomy. In this study, we compare the evolution of decellularized matrices with recellularized matrices by seeding it with human adipose-derived mesenchymal stem cells (ADSC) after implantation following partial cystectomy in rats. We discovered significant
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Preparation and characterization of methacrylated gelatin/bacterial cellulose composite hydrogels for cartilage tissue engineering. Regen. Biomater. (IF 4.882) Pub Date : 2019-12-19 Liling Gu,Tao Li,Xiongbo Song,Xianteng Yang,Senlei Li,Long Chen,Pingju Liu,Xiaoyuan Gong,Cheng Chen,Li Sun
Methacrylated gelatin (GelMA)/bacterial cellulose (BC) composite hydrogels have been successfully prepared by immersing BC particles in GelMA solution followed by photo-crosslinking. The morphology of GelMA/BC hydrogel was examined by scanning electron microscopy and compared with pure GelMA. The hydrogels had very well interconnected porous network structure, and the pore size decreased from 200 to
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Mineralized collagen-modified PMMA cement enhances bone integration and reduces fibrous encapsulation in the treatment of lumbar degenerative disc disease. Regen. Biomater. (IF 4.882) Pub Date : 2019-12-02 Long Yang,Jianjun Kong,Zhiye Qiu,Tieliang Shang,Siyu Chen,Rui Zhao,Maria Grazia Raucci,Xiao Yang,Zhanyong Wu
As a minimally invasive surgery, percutaneous cement discoplasty (PCD) is now contemplated to treat lumbar disc degeneration disease in elder population. Here, we investigated whether the osteogenic mineralized collagen (MC) modified polymethylmethacrylate (PMMA) cement could be a suitable material in PCD surgery. Injectability, hydrophilicity and mechanical properties of the MC-modified PMMA (PMMA-MC)
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Enhanced osteogenesis of hydroxyapatite scaffolds by coating with BMP-2-loaded short polylactide nanofiber: a new drug loading method for porous scaffolds. Regen. Biomater. (IF 4.882) Pub Date : 2019-11-07 Taotao Xu,Luyao Sheng,Lei He,Jie Weng,Ke Duan
Porous hydroxyapatite (HA) is widely used in porous forms to assist bone defect healing. However, further improvements in biological functions are desired for meeting complex clinical situations such as impaired bone regeneration in poor bone stock. The extracellular matrix (ECM) of human tissues is characterized by nanofibrous structures and a variety of signal molecules. Emulating these characteristics
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A coaxially extruded heterogeneous core-shell fiber with Schwann cells and neural stem cells. Regen. Biomater. (IF 4.882) Pub Date : 2019-11-07 Xinda Li,Dezhi Zhou,Zhizhong Jin,Hongqing Chen,Xuanzhi Wang,Xinzhi Zhang,Tao Xu
Cellular therapies play a critical role in the treatment of spinal cord injury (SCI). Compared with cell-seeded conduits, fully cellular grafts have more similarities with autografts, and thus might result in better regeneration effects. In this study, we fabricated Schwann cell (SC)-neural stem cell (NSC) core-shell alginate hydrogel fibers in a coaxial extrusion manner. The rat SC line RSC96 and
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Integrated prodrug micelles with two-photon bioimaging and pH-triggered drug delivery for cancer theranostics. Regen. Biomater. (IF 4.882) Pub Date : 2019-11-04 Hong Xu,Boxuan Ma,Jizhou Jiang,Sutong Xiao,Rongrong Peng,Weihua Zhuang,Gaocan Li,Yunbing Wang
Nanodrug carriers with fluorescence radiation are widely used in cancer diagnosis and therapy due to their real-time imaging, less side effect, better drug utilization as well as the good bioimaging ability. However, traditional nanocarriers still suffer from unexpectable drug leakage, unsatisfactory tumor-targeted drug delivery and shallow imaging depth, which limit their further application in cancer
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In situ sol-gel synthesis of hyaluronan derivatives bio-nanocomposite hydrogels. Regen. Biomater. (IF 4.882) Pub Date : 2019-10-18 U D'Amora,A Ronca,M G Raucci,S M Dozio,H Lin,Y Fan,X Zhang,L Ambrosio
The main driving idea of the present study was the comparison between two different chemical modifications of hyaluronic acid (HA) followed by the development of nanocomposite hydrogels directly in situ by biomineralization of photocrosslinkable HA polymers through sol-gel synthesis. In this way, it has been possible to overcome some limitations due to classical approaches based on the physical blending
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Inhibition of in-stent restenosis after graphene oxide double-layer drug coating with good biocompatibility. Regen. Biomater. (IF 4.882) Pub Date : 2019-10-17 Shuang Ge,Yadong Xi,Ruolin Du,Yuzhen Ren,Zichen Xu,Youhua Tan,Yazhou Wang,Tieying Yin,Guixue Wang
In this study, we designed a double layer-coated vascular stent of 316L stainless steel using an ultrasonic spray system to achieve both antiproliferation and antithrombosis. The coating included an inner layer of graphene oxide (GO) loaded with docetaxel (DTX) and an outer layer of carboxymethyl chitosan (CMC) loaded with heparin (Hep). The coated surface was uniform without aggregation and shedding
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The proper strategy to compress and protect plasmid DNA in the Pluronic L64-electropulse system for enhanced intramuscular gene delivery. Regen. Biomater. (IF 4.882) Pub Date : 2019-10-17 Yutong He,Yili Liu,Zhe Sun,Fei Han,James Zhenggui Tang,Rong Gao,Gang Wang
Intramuscular expression of functional proteins is a promising strategy for therapeutic purposes. Previously, we developed an intramuscular gene delivery method by combining Pluronic L64 and optimized electropulse, which is among the most efficient methods to date. However, plasmid DNAs (pDNAs) in this method were not compressed, making them unstable and inefficient in vivo. We considered that a proper
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Hyaluronic acid-curcumin conjugate suppresses the fibrotic functions of myofibroblasts from contractive joint by the PTGER2 demethylation. Regen. Biomater. (IF 4.882) Pub Date : 2019-10-17 Dongjie Yu,Ze Zhuang,Jianhua Ren,Xuefeng Hu,Zhe Wang,Jieyu Zhang,Yuansen Luo,Kun Wang,Ronghan He,Yunbing Wang
Joint contracture is a fibrotic complication induced by joint immobilization and trauma, which is characterized as excessive myofibroblast proliferation in joint capsule. The treatments of joint contracture are unsatisfied and patients are suffered from joint dysfunction. Our previous study has shown that curcumin can inhibit myofibroblast proliferation in vitro, but the major challenge is the low
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Migration of endothelial cells into photo-responsive hydrogels with tunable modulus under the presence of pro-inflammatory macrophages. Regen. Biomater. (IF 4.882) Pub Date : 2019-10-17 Wangbei Cao,Xuguang Li,Xingang Zuo,Changyou Gao
Cell migration in three-dimensional environment is extremely important for tissue regeneration and other biological processes. In this work, a model system was developed to study how endothelial cells (ECs) migrate into photo-responsive hydrogels under the presence of pro-inflammatory macrophages. The hydrogel was synthesized from hyaluronic acid grafted with coumarin and methacrylate moieties by both
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Accelerated mineralization on nanofibers via non-thermal atmospheric plasma assisted glutamic acid templated peptide conjugation. Regen. Biomater. (IF 4.882) Pub Date : 2019-08-14 Günnur Onak,Ozan Karaman
Surface modification by non-thermal atmospheric plasma (NTAP) treatment can produce significantly higher carboxylic groups on the nanofibers (NF) surface, which potentially can increase biomineralization of NF via promoting glutamic acid (GLU) templated peptide conjugation. Herein, electrospun poly(lactide-co-glycolide) (PLGA) scaffolds were treated with NTAP and conjugated with GLU peptide followed
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Iron oxide nanoparticles promote vascular endothelial cells survival from oxidative stress by enhancement of autophagy. Regen. Biomater. (IF 4.882) Pub Date : 2019-08-14 Jimei Duan,Jiuju Du,Rongrong Jin,Wencheng Zhu,Li Liu,Li Yang,Mengye Li,Qiyong Gong,Bin Song,James M Anderson,Hua Ai
Dextran-coated superparamagnetic iron oxide nanoparticles (Dex-SPIONs) are excellent magnetic resonance imaging contrast agents for disease diagnosis and therapy. They can be delivered to target tissues mainly though vascular endothelium cells, which are major targets of oxidative stress. In cardiovascular cells, autophagy serves primarily on a pro-survival approach that protects the cells from oxidative
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Bone remodeling effect of a chitosan and calcium phosphate-based composite. Regen. Biomater. (IF 4.882) Pub Date : 2019-08-14 Lilja Kjalarsdóttir,Arna Dýrfjörd,Atli Dagbjartsson,Elín H Laxdal,Gissur Örlygsson,Jóhannes Gíslason,Jón M Einarsson,Chuen-How Ng,Halldór Jónsson
Chitosan is a biocompatible polymer that has been widely studied for tissue engineering purposes. The aim of this research was to assess bone regenerative properties of an injectable chitosan and calcium phosphate-based composite and identify optimal degree of deacetylation (%DDA) of the chitosan polymer. Drill holes were generated on the left side of a mandible in Sprague-Dawley rats, and the hole
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Injectable mechanical pillows for attenuation of load-induced post-traumatic osteoarthritis. Regen. Biomater. (IF 4.882) Pub Date : 2019-08-14 Derek T Holyoak,Tibra A Wheeler,Marjolein C H van der Meulen,Ankur Singh
Osteoarthritis (OA) of the knee joint is a degenerative disease initiated by mechanical stress that affects millions of individuals. The disease manifests as joint damage and synovial inflammation. Post-traumatic osteoarthritis (PTOA) is a specific form of OA caused by mechanical trauma to the joint. The progression of PTOA is prevented by immediate post-injury therapeutic intervention. Intra-articular
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In vitro evaluation of 3D printed polycaprolactone scaffolds with angle-ply architecture for annulus fibrosus tissue engineering. Regen. Biomater. (IF 4.882) Pub Date : 2019-06-15 T R Christiani,E Baroncini,J Stanzione,A J Vernengo
Tissue engineering of the annulus fibrosus (AF) is currently being investigated as a treatment for intervertebral disc degeneration, a condition frequently associated with low back pain. The objective of this work was to use 3D printing to generate a novel scaffold for AF repair that mimics the structural and biomechanical properties of the native tissue. Multi-layer scaffolds were fabricated by depositing
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New injectable two-step forming hydrogel for delivery of bioactive substances in tissue regeneration. Regen. Biomater. (IF 4.882) Pub Date : 2019-06-15 Edgar Pérez-Herrero,Patricia García-García,Jaime Gómez-Morales,Matias Llabrés,Araceli Delgado,Carmen Évora
A hydrogel based on chitosan, collagen, hydroxypropyl-γ-cyclodextrin and polyethylene glycol was developed and characterized. The incorporation of nano-hydroxyapatite and pre-encapsulated hydrophobic/hydrophilic model drugs diminished the porosity of hydrogel from 81.62 ± 2.25% to 69.98 ± 3.07%. Interactions between components of hydrogel, demonstrated by FTIR spectroscopy and rheology, generated a
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Advances of injectable hydrogel-based scaffolds for cartilage regeneration. Regen. Biomater. (IF 4.882) Pub Date : 2019-06-15 Jiawei Li,Guojun Chen,Xingquan Xu,Peter Abdou,Qing Jiang,Dongquan Shi,Zhen Gu
Articular cartilage is an important load-bearing tissue distributed on the surface of diarthrodial joints. Due to its avascular, aneural and non-lymphatic features, cartilage has limited self-regenerative properties. To date, the utilization of biomaterials to aid in cartilage regeneration, especially through the use of injectable scaffolds, has attracted considerable attention. Various materials,
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Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis. Regen. Biomater. (IF 4.882) Pub Date : 2019-06-15 Amanda Pentecost,Min Ju Kim,Sangmin Jeon,Young Ji Ko,Ick Chan Kwon,Yury Gogotsi,Kwangmeyung Kim,Kara L Spiller
We previously demonstrated that octadecylamine-functionalized nanodiamond (ND-ODA) and dexamethasone (Dex)-adsorbed ND-ODA (ND-ODA-Dex) promoted anti-inflammatory and pro-regenerative behavior in human macrophages in vitro. In this study, we performed a pilot study to investigate if these immunomodulatory effects translate when used as a treatment for rheumatoid arthritis in mice. Following local injection
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Cell and biomaterial-based approaches to uterus regeneration. Regen. Biomater. (IF 4.882) Pub Date : 2019-04-26 Feiran Liu,Shiqi Hu,Shaowei Wang,Ke Cheng
Asherman's syndrome (AS) is an endometrial disorder in which intrauterine adhesions crowd the uterine cavity and wall. The fibrotic adhesions are primarily the result of invasive uterine procedures that usually involve the insertion of surgical equipment into the uterus. This syndrome is accompanied by a number of clinical manifestations, including irregular or painful menstruation and infertility
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