当前期刊: Nano Today Go to current issue    加入关注   
显示样式:        排序: 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Mechanistic understanding of the electrocatalytic CO2 reduction reaction – New developments based on advanced instrumental techniques
    Nano Today (IF 16.582) Pub Date : 2020-01-16
    Ying Zhang; Si-Xuan Guo; Xiaolong Zhang; Alan M. Bond; Jie Zhang
    更新日期:2020-01-17
  • Nanoporous core@shell particles: Design, preparation, applications in bioadsorption and biocatalysis
    Nano Today (IF 16.582) Pub Date : 2020-01-16
    Haiyang Su; Qiang Tian; Cameron-Alexander Hurd Price; Lin Xu; Kun Qian; Jian Liu
    更新日期:2020-01-16
  • Heteroatom doping of two-dimensional materials: From graphene to chalcogenides
    Nano Today (IF 16.582) Pub Date : 2020-01-14
    Haoyue Zhu; Xin Gan; Amber McCreary; Ruitao Lv; Zhong Lin; Mauricio Terrones
    更新日期:2020-01-15
  • Nanomaterials to avoid and destroy protein aggregates
    Nano Today (IF 16.582) Pub Date : 2020-01-11
    Félix Sauvage; Joost Schymkowitz; Frederic Rousseau; Bela Z. Schmidt; Katrien Remaut; Kevin Braeckmans; Stefaan C. De Smedt
    更新日期:2020-01-13
  • Point-defect-optimized electron distribution for enhanced electrocatalysis: Towards the perfection of the imperfections
    Nano Today (IF 16.582) Pub Date : 2020-01-06
    Shilong Jiao; Xianwei Fu; Li Zhang; Yu-Jia Zeng; Hongwen Huang
    更新日期:2020-01-06
  • 更新日期:2020-01-06
  • 更新日期:2020-01-04
  • Non-oxide semiconductors for artificial photosynthesis: Progress on photoelectrochemical water splitting and carbon dioxide reduction
    Nano Today (IF 16.582) Pub Date : 2019-12-27
    Jianyong Feng; Huiting Huang; Shicheng Yan; Wenjun Luo; Tao Yu; Zhaosheng Li; Zhigang Zou
    更新日期:2019-12-27
  • Novel properties and applications of chiral inorganic nanostructures
    Nano Today (IF 16.582) Pub Date : 2019-12-20
    Lian Xiao; Tingting An; Lin Wang; Xiaoling Xu; Handong Sun
    更新日期:2019-12-21
  • Self-healing polymers with nanomaterials and nanostructures
    Nano Today (IF 16.582) Pub Date : 2019-12-20
    Lei Zhai; Ameya Narkar; Kollbe Ahn
    更新日期:2019-12-20
  • Skin in the diagnostics game: Wearable biosensor nano- and microsystems for medical diagnostics
    Nano Today (IF 16.582) Pub Date : 2019-12-20
    Muamer Dervisevic; Maria Alba; Beatriz Prieto-Simon; Nicolas H. Voelcker
    更新日期:2019-12-20
  • Nanofabrication approaches for functional three-dimensional architectures
    Nano Today (IF 16.582) Pub Date : 2019-12-20
    Hangbo Zhao; Yongjun Lee; Mengdi Han; Bhupendra K. Sharma; Xuexian Chen; Jong-Hyun Ahn; John A. Rogers
    更新日期:2019-12-20
  • From colloidal dispersions to aerogels: How to master nanoparticle gelation
    Nano Today (IF 16.582) Pub Date : 2019-12-20
    Fabian Matter; Ana Laura Luna; Markus Niederberger
    更新日期:2019-12-20
  • Three dimension nanoparticle assemblies with tunable plasmonics via a layer-by-layer process
    Nano Today (IF 16.582) Pub Date : 2019-12-19
    Thomas L. Derrien; Shogo Hamada; Max Zhou; Detlef-M. Smilgies; Dan Luo
    更新日期:2019-12-19
  • Nanowire probes could drive high-resolution brain-machine interfaces
    Nano Today (IF 16.582) Pub Date : 2019-12-09
    Anqi Zhang, Yunlong Zhao, Siheng Sean You, Charles M. Lieber
    更新日期:2019-12-09
  • 更新日期:2019-11-30
  • Nano-pesticides: A great challenge for biodiversity? The need for a broader perspective
    Nano Today (IF 16.582) Pub Date : 2019-11-30
    Evgenios Agathokleous, ZhaoZhong Feng, Ivo Iavicoli, Edward J. Calabrese
    更新日期:2019-11-30
  • Nanoparticles-based magnetic and photo induced hyperthermia for cancer treatment
    Nano Today (IF 16.582) Pub Date : 2019-11-22
    S.K. Sharma, Navadeep Shrivastava, Francesco Rossi, Le Duc Tung, Nguyen Thi Kim Thanh

    Nanoscience provides several modalities to combat cancer disease effectively. Magnetic hyperthermia and photothermal therapy techniques are central research themes among various groups in the world by utilizing magnetic and optical characteristics of distinct or composite nanoentities. This review provides the current research on both the techniques and their successes towards clinical translation. This review discusses about the various heating mechanisms involved in magnetic and photo-induced hyperthermia. We have evaluated potential functional nanoparticles with excellent properties capable of providing innovative future solutions to current problems associated with these therapies. Several factors (extracellular and intracellular) have been covered and explained which may affect such thermal treatments. We have provided some instrumental and technical details of both the techniques that are important for consideration in using these modalities of treatments. A direct comparison of these two techniques and a further need of the combined therapy (magnetic hyperthermia plus photothermal therapy) was highlighted as a new pathway for cancer treatments.

    更新日期:2019-11-26
  • Engineered nanomedicines with enhanced tumor penetration
    Nano Today (IF 16.582) Pub Date : 2019-11-22
    Jianxun Ding, Jinjin Chen, Liqian Gao, Zhongyu Jiang, Yu Zhang, Mingqiang Li, Qicai Xiao, Su Seong Lee, Xuesi Chen

    Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is inefficient tumor penetration caused by specific tumor microenvironments, such as insufficient blood supply, high-density tumor cells and extracellular matrix, and increased interstitial fluid pressure. To date, several strategies, including the modulation of tumor microenvironments and optimization of nanoparticle properties, have been reported to improve the tumor penetration of nanomedicines, but these traditional strategies still have limitations. Recently, with unique strategies like tumor-penetrating peptide-mediated transcellular transport, the multifunctional transformable nanoparticles have emerged as an advanced generation of nanomedicine with superior tumor penetration capabilities. In this review, the latest development and limitations of nanomedicines are summarized, and prospects for improving tumor penetration are discussed.

    更新日期:2019-11-26
  • Three dimensional nanosuperstructures made of two-dimensional materials by design: Synthesis, properties, and applications
    Nano Today (IF 16.582) Pub Date : 2019-11-22
    Weigu Li, Yun Huang, Yifei Liu, Marshall C. Tekell, Donglei (Emma) Fan
    更新日期:2019-11-22
  • Modulating the oxophilic properties of inorganic nanomaterials for electrocatalysis of small carbonaceous molecules
    Nano Today (IF 16.582) Pub Date : 2019-11-21
    Fengxia Wu, Ling Zhang, Jianping Lai, Rafael Luque, Wenxin Niu, Guobao Xu
    更新日期:2019-11-22
  • Nano-pesticides: A great challenge for biodiversity?
    Nano Today (IF 16.582) Pub Date : 2019-07-24
    Yan Sun, Jie Liang, Lin Tang, Hui Li, Yi Zhu, Danni Jiang, Biao Song, Ming Chen, Guangming Zeng
    更新日期:2019-11-18
  • Porous MXenes: Synthesis, structures, and applications
    Nano Today (IF 16.582) Pub Date : 2019-11-17
    Fanxing Bu, Moustafa M. Zagho, Yasseen Ibrahim, Bing Ma, Ahmed Elzatahry, Dongyuan Zhao
    更新日期:2019-11-18
  • Temperature dependence of the pyro-phototronic effect in self-powered p-Si/n-ZnO nanowires heterojuncted ultraviolet sensors
    Nano Today (IF 16.582) Pub Date : 2019-11-16
    Jianqi Dong, Zhengjun Wang, Xingfu Wang, Zhong Lin Wang
    更新日期:2019-11-18
  • Recent advances in upconversion nanocrystals: Expanding the kaleidoscopic toolbox for emerging applications
    Nano Today (IF 16.582) Pub Date : 2019-11-16
    Kezhi Zheng, Kang Yong Loh, Yu Wang, Qiushui Chen, Jingyue Fan, Taeyoung Jung, Sang Hwan Nam, Yung Dong Suh, Xiaogang Liu
    更新日期:2019-11-18
  • Hard-template synthesis of three-dimensional interconnected carbon networks: Rational design, hybridization and energy-related applications
    Nano Today (IF 16.582) Pub Date : 2019-11-15
    Shan Zhu, Naiqin Zhao, Jiajun Li, Xiaoyang Deng, Junwei Sha, Chunnian He
    更新日期:2019-11-15
  • Recent advances in nanosized drug delivery systems for overcoming the barriers to anti-PD immunotherapy of cancer
    Nano Today (IF 16.582) Pub Date : 2019-11-14
    Xiaochen Liu, Dangge Wang, Pengcheng Zhang, Yaping Li
    更新日期:2019-11-14
  • Nanostructured substrates for isolation of circulating tumor cells.
    Nano Today (IF 16.582) Pub Date : 2014-06-20
    Lixue Wang,Waseem Asghar,Utkan Demirci,Yuan Wan

    Circulating tumor cells (CTCs) originate from the primary tumor mass and enter into the peripheral bloodstream. CTCs hold the key to understanding the biology of metastasis and also play a vital role in cancer diagnosis, prognosis, disease monitoring, and personalized therapy. However, CTCs are rare in blood and hard to isolate. Additionally, the viability of CTCs can easily be compromised under high shear stress while releasing them from a surface. The heterogeneity of CTCs in biomarker expression makes their isolation quite challenging; the isolation efficiency and specificity of current approaches need to be improved. Nanostructured substrates have emerged as a promising biosensing platform since they provide better isolation sensitivity at the cost of specificity for CTC isolation. This review discusses major challenges faced by CTC isolation techniques and focuses on nanostructured substrates as a platform for CTC isolation.

    更新日期:2019-11-01
  • FUNCTIONAL NANOPARTICLES FOR MOLECULAR IMAGING GUIDED GENE DELIVERY.
    Nano Today (IF 16.582) Pub Date : 2010-12-01
    Gang Liu,Magdalena Swierczewska,Seulki Lee,Xiaoyuan Chen

    Gene therapy has great potential to bring tremendous changes in treatment of various diseases and disorders. However, one of the impediments to successful gene therapy is the inefficient delivery of genes to target tissues and the inability to monitor delivery of genes and therapeutic responses at the targeted site. The emergence of molecular imaging strategies has been pivotal in optimizing gene therapy; since it can allow us to evaluate the effectiveness of gene delivery noninvasively and spatiotemporally. Due to the unique physiochemical properties of nanomaterials, numerous functional nanoparticles show promise in accomplishing gene delivery with the necessary feature of visualizing the delivery. In this review, recent developments of nanoparticles for molecular imaging guided gene delivery are summarized.

    更新日期:2019-11-01
  • Corrigendum to "3D printed bionic nanodevices" [Nano Today 11 (2016) 330-350].
    Nano Today (IF 16.582) Pub Date : 2019-06-13
    Yong Lin Kong,Maneesh K Gupta,Blake N Johnson,Michael C McAlpine

    [This corrects the article PMC5016035.].

    更新日期:2019-11-01
  • 3D Printed Bionic Nanodevices.
    Nano Today (IF 16.582) Pub Date : 2016-09-13
    Yong Lin Kong,Maneesh K Gupta,Blake N Johnson,Michael C McAlpine

    The ability to three-dimensionally interweave biological and functional materials could enable the creation of bionic devices possessing unique and compelling geometries, properties, and functionalities. Indeed, interfacing high performance active devices with biology could impact a variety of fields, including regenerative bioelectronic medicines, smart prosthetics, medical robotics, and human-machine interfaces. Biology, from the molecular scale of DNA and proteins, to the macroscopic scale of tissues and organs, is three-dimensional, often soft and stretchable, and temperature sensitive. This renders most biological platforms incompatible with the fabrication and materials processing methods that have been developed and optimized for functional electronics, which are typically planar, rigid and brittle. A number of strategies have been developed to overcome these dichotomies. One particularly novel approach is the use of extrusion-based multi-material 3D printing, which is an additive manufacturing technology that offers a freeform fabrication strategy. This approach addresses the dichotomies presented above by (1) using 3D printing and imaging for customized, hierarchical, and interwoven device architectures; (2) employing nanotechnology as an enabling route for introducing high performance materials, with the potential for exhibiting properties not found in the bulk; and (3) 3D printing a range of soft and nanoscale materials to enable the integration of a diverse palette of high quality functional nanomaterials with biology. Further, 3D printing is a multi-scale platform, allowing for the incorporation of functional nanoscale inks, the printing of microscale features, and ultimately the creation of macroscale devices. This blending of 3D printing, novel nanomaterial properties, and 'living' platforms may enable next-generation bionic systems. In this review, we highlight this synergistic integration of the unique properties of nanomaterials with the versatility of extrusion-based 3D printing technologies to interweave nanomaterials and fabricate novel bionic devices.

    更新日期:2019-11-01
  • Fluorescent nanoprobes for sensing and imaging of metal ions: recent advances and future perspectives.
    Nano Today (IF 16.582) Pub Date : 2016-11-08
    JingJing Zhang,FangFang Cheng,JingJing Li,Jun-Jie Zhu,Yi Lu

    Recent advances in nanoscale science and technology have generated nanomaterials with unique optical properties. Over the past decade, numerous fluorescent nanoprobes have been developed for highly sensitive and selective sensing and imaging of metal ions, both in vitro and in vivo. In this review, we provide an overview of the recent development of the design and optical properties of the different classes of fluorescent nanoprobes based on noble metal nanomaterials, upconversion nanoparticles, semiconductor quantum dots, and carbon-based nanomaterials. We further detail their application in the detection and quantification of metal ions for environmental monitoring, food safety, medical diagnostics, as well as their use in biomedical imaging in living cells and animals.

    更新日期:2019-11-01
  • Cell-derived vesicles for drug therapy and diagnostics: opportunities and challenges.
    Nano Today (IF 16.582) Pub Date : 2015-06-01
    Gregor Fuhrmann,Inge K Herrmann,Molly M Stevens

    Extracellular vesicles are small lipid-based membrane-bound entities shed by cells under both physiological and pathological conditions. Their discovery as intercellular communicators through transfer of nucleic acid- and protein-based cargos between cells locally and at distance in a highly specific manner has created recent excitement. The information they transport and their composition may vary depending on the cell of origin as well as the eliciting stimulus. Such sensitive changes in vesicle characteristics hold significant promise for the improved diagnosis of pathological conditions, including infections and neoplastic lesions in a minimally invasive way. Similarly, these cell-derived vesicles exhibit promising characteristics that could enhance drug targeting efficiencies. Recent developments in the field have aimed at studying EVs as novel drug carriers due to their natural composition, biological function and selective cell interaction. In this review, we discuss new research avenues in diagnostics and drug therapy based on extracellular vesicles. We show how cell-derived vesicles can be harvested and engineered to meet application-specific design requirements. We finally discuss potential risks encountered when translating extracellular vesicle based approaches into (pre)clinical applications.

    更新日期:2019-11-01
  • Building Nanostructures with Drugs.
    Nano Today (IF 16.582) Pub Date : 2016-04-12
    Wang Ma,Andrew G Cheetham,Honggang Cui

    The convergence of nanoscience and drug delivery has prompted the formation of the field of nanomedicine, one that exploits the novel physicochemical and biological properties of nanostructures for improved medical treatments and reduced side effects. Until recently, this nanostructure-mediated strategy considered the drug to be solely a biologically active compound to be delivered, and its potential as a molecular building unit remained largely unexplored. A growing trend within nanomedicine has been the use of drug molecules to build well-defined nanostructures of various sizes and shapes. This strategy allows for the creation of self-delivering supramolecular nanomedicines containing a high and fixed drug content. Through rational design of the number and type of the drug incorporated, the resulting nanostructures can be tailored to assume various morphologies (e.g. nanospheres, rods, nanofibers, or nanotubes) for a particular mode of administration such as systemic, topical, and local delivery. This review covers the recent advances in this rapidly developing field, with the aim of providing an in-depth evaluation of the exciting opportunities that this new field could create to improve the current clinical practice of nanomedicine.

    更新日期:2019-11-01
  • Photoresponsive nanoparticles for drug delivery.
    Nano Today (IF 16.582) Pub Date : 2015-12-09
    Alina Y Rwei,Weiping Wang,Daniel S Kohane

    Externally triggerable drug delivery systems provide a strategy for the delivery of therapeutic agents preferentially to a target site, presenting the ability to enhance therapeutic efficacy while reducing side effects. Light is a versatile and easily tuned external stimulus that can provide spatiotemporal control. Here we will review the use of nanoparticles in which light triggers drug release or induces particle binding to tissues (phototargeting).

    更新日期:2019-11-01
  • Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom.
    Nano Today (IF 16.582) Pub Date : 2015-04-18
    Weiqiang Chen,Yue Shao,Xiang Li,Gang Zhao,Jianping Fu

    During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with tissue/organ-specific nanoscale topographical cues to adopt different fates and functions. Attributed to their capability of self-renewal and differentiation into most types of somatic cells, stem cells also hold tremendous promise for regenerative medicine and drug screening. However, a major challenge remains as to achieve fate control of stem cells in vitro with high specificity and yield. Recent exciting advances in nanotechnology and materials science have enabled versatile, robust, and large-scale stem cell engineering in vitro through developments of synthetic nanotopographical surfaces mimicking topological features of stem cell niches. In addition to generating new insights for stem cell biology and embryonic development, this effort opens up unlimited opportunities for innovations in stem cell-based applications. This review is therefore to provide a summary of recent progress along this research direction, with perspectives focusing on emerging methods for generating nanotopographical surfaces and their applications in stem cell research. Furthermore, we provide a review of classical as well as emerging cellular mechano-sensing and -transduction mechanisms underlying stem cell nanotopography sensitivity and also give some hypotheses in regard to how a multitude of signaling events in cellular mechanotransduction may converge and be integrated into core pathways controlling stem cell fate in response to extracellular nanotopography.

    更新日期:2019-11-01
  • Targeted Nanodelivery of Drugs and Diagnostics.
    Nano Today (IF 16.582) Pub Date : 2010-06-15
    Margaret A Phillips,Martin L Gran,Nicholas A Peppas

    Nanomaterials for targeted delivery are uniquely capable of localizing delivery of therapeutics and diagnostics to diseased tissues. The ability to achieve high, local concentrations of drugs or image contrast agents at a target site provides the opportunity for improved system performance and patient outcomes along with reduced systemic dosing. In this review, the design of targeted nanodelivery systems is discussed with an emphasis on in vivo performance, the physicochemical properties that affect localization at the target site, and the incorporation of therapeutic drugs into these systems.

    更新日期:2019-11-01
  • Molecular imaging and therapy of cancer with radiolabeled nanoparticles.
    Nano Today (IF 16.582) Pub Date : 2010-02-18
    Hao Hong,Yin Zhang,Jiangtao Sun,Weibo Cai

    This review summarizes the current state-of-the-art of radiolabeled nanoparticles for molecular imaging and internal radiotherapy applications targeting cancer. With the capacity to provide enormous flexibility, radiolabeled nanoparticles have the potential to profoundly impact disease diagnosis and patient management in the near future. Currently, the major challenges facing the research on radiolabeled nanoparticles are desirable (tumor) targeting efficacy, robust chemistry for both radionuclide encapsulation/incorporation and targeting ligand conjugation, favorable safety profile, as well as certain commercial and regulatory hurdles.

    更新日期:2019-11-01
  • Nano-imaging enabled via self-assembly.
    Nano Today (IF 16.582) Pub Date : 2014-12-17
    Euan McLeod,Aydogan Ozcan

    Imaging object details with length scales below approximately 200 nm has been historically difficult for conventional microscope objective lenses because of their inability to resolve features smaller than one-half the optical wavelength. Here we review some of the recent approaches to surpass this limit by harnessing self-assembly as a fabrication mechanism. Self-assembly can be used to form individual nano- and micro-lenses, as well as to form extended arrays of such lenses. These lenses have been shown to enable imaging with resolutions as small as 50 nm half-pitch using visible light, which is well below the Abbe diffraction limit. Furthermore, self-assembled nano-lenses can be used to boost contrast and signal levels from small nano-particles, enabling them to be detected relative to background noise. Finally, alternative nano-imaging applications of self-assembly are discussed, including three-dimensional imaging, enhanced coupling from light-emitting diodes, and the fabrication of contrast agents such as quantum dots and nanoparticles.

    更新日期:2019-11-01
  • A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors.
    Nano Today (IF 16.582) Pub Date : 2014-07-11
    Sabine Hauert,Spring Berman,Radhika Nagpal,Sangeeta N Bhatia

    Targeted nanoparticles are increasingly being engineered for the treatment of cancer. By design, they can passively accumulate in tumors, selectively bind to targets in their environment, and deliver localized treatments. However, the penetration of targeted nanoparticles deep into tissue can be hindered by their slow diffusion and a high binding affinity. As a result, they often localize to areas around the vessels from which they extravasate, never reaching the deep-seeded tumor cells, thereby limiting their efficacy. To increase tissue penetration and cellular accumulation, we propose generalizable guidelines for nanoparticle design and validate them using two different computer models that capture the potency, motion, binding kinetics, and cellular internalization of targeted nanoparticles in a section of tumor tissue. One strategy that emerged from the models was delaying nanoparticle binding until after the nanoparticles have had time to diffuse deep into the tissue. Results show that nanoparticles that are designed according to these guidelines do not require fine-tuning of their kinetics or size and can be administered in lower doses than classical targeted nanoparticles for a desired tissue penetration in a large variety of tumor scenarios. In the future, similar models could serve as a testbed to explore engineered tissue-distributions that arise when large numbers of nanoparticles interact in a tumor environment.

    更新日期:2019-11-01
  • Beyond Biomarkers: Identifying Cell State using Unbiased Nanosensor Arrays.
    Nano Today (IF 16.582) Pub Date : 2012-11-20
    Bradley Duncan,S Gokhan Elci,Vincent M Rotello

    Traditional cell detection based on biomarkers relies on specific lock-and-key recognition. However, many diseases either do not have obvious biomarkers or these markers are currently unknown. Unbiased sensor arrays based on nanoparticles use selective interactions to generate bioprofiles capable of identifying cell type and state. As a result, these arrays can differentiate subtle variations on the cell surfaces, presenting a potential approach for personalized diagnostics.

    更新日期:2019-11-01
  • Advances in Resistive Pulse Sensors: Devices bridging the void between molecular and microscopic detection.
    Nano Today (IF 16.582) Pub Date : 2011-10-29
    Darby Kozak,Will Anderson,Robert Vogel,Matt Trau

    Since the first reported use of a biological ion channel to detect differences in single stranded genomic base pairs in 1996, a renaissance in nanoscale resistive pulse sensors has ensued. This resurgence of a technique originally outlined and commercialized over fifty years ago has largely been driven by advances in nanoscaled fabrication, and ultimately, the prospect of a rapid and inexpensive means for genomic sequencing as well as other macromolecular characterization. In this pursuit, the potential application of these devices to characterize additional properties such as the size, shape, charge, and concentration of nanoscaled materials (10 - 900 nm) has been largely overlooked. Advances in nanotechnology and biotechnology are driving the need for simple yet sensitive individual object readout devices such as resistive pulse sensors. This review will examine the recent progress in pore-based sensing in the nanoscale range. A detailed analysis of three new types of pore sensors - in-series, parallel, and size-tunable pores - has been included. These pores offer improved measurement sensitivity over a wider particle size range. The fundamental physical chemistry of these techniques, which is still evolving, will be reviewed.

    更新日期:2019-11-01
  • Multifunctional Quantum Dots for Personalized Medicine.
    Nano Today (IF 16.582) Pub Date : 2010-02-18
    Pavel Zrazhevskiy,Xiaohu Gao

    Successes in biomedical research and state-of-the-art medicine have undoubtedly improved the quality of life. However, a number of diseases, such as cancer, immunodeficiencies, and neurological disorders, still evade conventional diagnostic and therapeutic approaches. A transformation towards personalized medicine may help to combat these diseases. For this, identification of disease molecular fingerprints and their association with prognosis and targeted therapy must become available. Quantum dots (QDs), semiconductor nanocrystals with unique photo-physical properties, represent a novel class of fluorescence probes to address many of the needs of personalized medicine. This review outlines the properties of QDs that make them a suitable platform for advancing personalized medicine, examines several proof-of-concept studies showing utility of QDs for clinically relevant applications, and discusses current challenges in introducing QDs into clinical practice.

    更新日期:2019-11-01
  • Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials.
    Nano Today (IF 16.582) Pub Date : 2011-08-10
    Matthias T Stephan,Darrell J Irvine

    Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.

    更新日期:2019-11-01
  • Emerging links between surface nanotechnology and endocytosis: impact on nonviral gene delivery.
    Nano Today (IF 16.582) Pub Date : 2011-03-09
    Andrew F Adler,Kam W Leong

    Significant effort continues to be exerted toward the improvement of transfection mediated by nonviral vectors. These endeavors are often focused on the design of particulate carriers with properties that encourage efficient accumulation at the membrane surface, particle uptake, and endosomal escape. Despite its demonstrated importance in successful nonviral transfection, relatively little investigation has been done to understand the pressures driving internalized vectors into favorable nondegradative endocytic pathways. Improvements in transfection efficiency have been noted for complexes delivered with a substrate-mediated approach, but the reasons behind such enhancements remain unclear. The phenotypic changes exhibited by cells interacting with nano- and micro-featured substrates offer hints that may explain these effects. This review describes nanoscale particulate and substrate parameters that influence both the uptake of nonviral gene carriers and the endocytic phenotype of interacting cells, and explores the molecular links that may mediate these interactions. Substrate-mediated control of endocytosis represents an exciting new design parameter that will guide the creation of efficient transgene carriers.

    更新日期:2019-11-01
  • Microfluidic tools for cell biological research.
    Nano Today (IF 16.582) Pub Date : 2010-12-15
    Guilhem Velve-Casquillas,Maël Le Berre,Matthieu Piel,Phong T Tran

    Microfluidic technology is creating powerful tools for cell biologists to control the complete cellular microenvironment, leading to new questions and new discoveries. We review here the basic concepts and methodologies in designing microfluidic devices, and their diverse cell biological applications.

    更新日期:2019-11-01
  • PROTEIN TEMPLATES IN HARD TISSUE ENGINEERING.
    Nano Today (IF 16.582) Pub Date : 2010-08-31
    Anne George,Sriram Ravindran

    Biomineralization processes such as formation of bones and teeth require controlled mineral deposition and self-assembly into hierarchical biocomposites with unique mechanical properties. Ideal biomaterials for regeneration and repair of hard tissues must be biocompatible, possess micro and macroporosity for vascular invasion, provide surface chemistry and texture that facilitate cell attachment, proliferation, differentiation of lineage specific progenitor cells, and induce deposition of calcium phosphate mineral. To expect in-vivo like cellular response several investigators have used extracellular matrix proteins as templates to recreate in-vivo microenvironment for regeneration of hard tissues. Recently, several novel methods of designing tissue repair and restoration materials using bioinspired strategies are currently being formulated. Nanoscale structured materials can be fabricated via the spontaneous organization of self-assembling proteins to construct hierarchically organized nanomaterials. The advantage of such a method is that polypeptides can be specifically designed as building blocks incorporated with molecular recognition features and spatially distributed bioactive ligands that would provide a physiological environment for cells in-vitro and in-vivo. This is a rapidly evolving area and provides a promising platform for future development of nanostructured templates for hard tissue engineering. In this review we try to highlight the importance of proteins as templates for regeneration and repair of hard tissues as well as the potential of peptide based nanomaterials for regenerative therapies.

    更新日期:2019-11-01
  • Host-guest interactions mediated nano-assemblies using cyclodextrin-containing hydrophilic polymers and their biomedical applications.
    Nano Today (IF 16.582) Pub Date : 2010-08-21
    Jianxiang Zhang,Peter X Ma

    Supramolecular nanostructures assembled by polymeric amphiphiles have been intensively studied during the last two decades. Such nanocarriers may be engineered to possess on-demand bio-responsitivity for the prevention, diagnosis, and treatment of human diseases. The successful development of several nanoassembly-based polymer therapeutics further encouraged scientists to develop nano-vehicles to achieve controlled release, enhanced efficacy, improved specificity and reduced toxicity. Different from the abundant existing literatures on the hydrophobically or electrostatically driven self-assemblies and their therapeutic applications, this article reviews host-guest interaction mediated nanoassemblies, especially those constructed using cyclodextrins as the host entities. The excellent biocompatibility, complexation capacity, and chemical-sensitivity of cyclodextrin make cyclodextrin-containing polymers attractive to construct host-guest nanoassemblies. Such nanocarriers may be advantageous also because of the broad availability of cyclodextrins, their flexibility for structure/property modulation and their chemical-responsive characteristics.

    更新日期:2019-11-01
  • Integrated Microfluidic Reactors.
    Nano Today (IF 16.582) Pub Date : 2010-03-09
    Wei-Yu Lin,Yanju Wang,Shutao Wang,Hsian-Rong Tseng

    Microfluidic reactors exhibit intrinsic advantages of reduced chemical consumption, safety, high surface-area-to-volume ratios, and improved control over mass and heat transfer superior to the macroscopic reaction setting. In contract to a continuous-flow microfluidic system composed of only a microchannel network, an integrated microfluidic system represents a scalable integration of a microchannel network with functional microfluidic modules, thus enabling the execution and automation of complicated chemical reactions in a single device. In this review, we summarize recent progresses on the development of integrated microfluidics-based chemical reactors for (i) parallel screening of in situ click chemistry libraries, (ii) multistep synthesis of radiolabeled imaging probes for positron emission tomography (PET), (iii) sequential preparation of individually addressable conducting polymer nanowire (CPNW), and (iv) solid-phase synthesis of DNA oligonucleotides. These proof-of-principle demonstrations validate the feasibility and set a solid foundation for exploring a broad application of the integrated microfluidic system.

    更新日期:2019-11-01
  • Simultaneous Non-invasive Analysis of DNA Condensation and Stability by Two-step QD-FRET.
    Nano Today (IF 16.582) Pub Date : 2010-02-18
    Hunter H Chen,Yi-Ping Ho,Xuan Jiang,Hai-Quan Mao,Tza-Huei Wang,Kam W Leong

    Nanoscale vectors comprised of cationic polymers that condense DNA to form nanocomplexes are promising options for gene transfer. The rational design of more efficient nonviral gene carriers will be possible only with better mechanistic understanding of the critical rate-limiting steps, such as nanocomplex unpacking to release DNA and degradation by nucleases. We present a two-step quantum dot fluorescence resonance energy transfer (two-step QD-FRET) approach to simultaneously and non-invasively analyze DNA condensation and stability. Plasmid DNA, double-labeled with QD (525 nm emission) and nucleic acid dyes, were complexed with Cy5-labeled cationic gene carriers. The QD donor drives energy transfer stepwise through the intermediate nucleic acid dye to the final acceptor Cy5. At least three distinct states of DNA condensation and integrity were distinguished in single particle manner and within cells by quantitative ratiometric analysis of energy transfer efficiencies. This novel two-step QD-FRET method allows for more detailed assessment of the onset of DNA release and degradation simultaneously.

    更新日期:2019-11-01
  • High-resolution, serial intravital microscopic imaging of nanoparticle delivery and targeting in a small animal tumor model.
    Nano Today (IF 16.582) Pub Date : 2013-11-26
    Bryan Ronain Smith,Cristina Zavaleta,Jarrett Rosenberg,Ricky Tong,John Ramunas,Zhuang Liu,Hongjie Dai,Sanjiv Sam Gambhir

    Nanoparticles are under active investigation for the detection and treatment of cancer. Yet our understanding of nanoparticle delivery to tumors is limited by our ability to observe the uptake process on its own scale in living subjects. We chose to study single-walled carbon nanotubes (SWNTs) because they exhibit among the highest levels of tumor uptake across the wide variety of available nanoparticles. We target them using RGD (arginine-glycine-aspartic acid) peptide which directs them to integrins overexpressed on tumor vasculature and on the surface of some tumor cells (e.g., U87MG as used here). We employ intravital microscopy (IVM) to quantitatively examine the spatiotemporal framework of targeted SWNT uptake in a murine tumor model. IVM provided a dynamic microscale window into nanoparticle circulation, binding to tumor blood vessels, extravasation, binding to tumor cells, and tumor retention. RGD-SWNTs bound to tumor vasculature significantly more than controls (P<0.0001). RGD-SWNTs extravasated similarly compared to control RAD-SWNTs, but post-extravasation we observed as RGD-SWNTs eventually bound to individual tumor cells significantly more than RAD-SWNTs (p<0.0001) over time. RGD-SWNTs and RAD-SWNTs displayed similar signal in tumor for a week, but over time their curves significantly diverged (p<0.001) showing increasing RGD-SWNTs relative to untargeted SWNTs. We uncovered the complex spatiotemporal interplay between these competing uptake mechanisms. Specific uptake was delimited to early (1-6 hours) and late (1-4 weeks) time-points, while non-specific uptake dominated from 6 hours to 1 week. Our analysis revealed critical, quantitative insights into the dynamic, multifaceted mechanisms implicated in ligand-targeted SWNT accumulation in tumor using real-time observation.

    更新日期:2019-11-01
  • Triggered Nanoparticles as Therapeutics.
    Nano Today (IF 16.582) Pub Date : 2013-10-26
    Chang Soo Kim,Bradley Duncan,Brian Creran,Vincent M Rotello

    Drug delivery systems (DDSs) face several challenges including site-specific delivery, stability, and the programmed release of drugs. Engineered nanoparticle (NP) surfaces with responsive moieties can enhance the efficacy of DDSs for in vitro and in vivo systems. This triggering process can be achieved through both endogenous (biologically controlled release) and exogenous (external stimuli controlled release) activation. In this review, we will highlight recent examples of the use of triggered release strategies of engineered nanomaterials for in vitro and in vivo applications.

    更新日期:2019-11-01
  • Nanoelectronics-biology frontier: From nanoscopic probes for action potential recording in live cells to three-dimensional cyborg tissues.
    Nano Today (IF 16.582) Pub Date : 2013-09-28
    Xiaojie Duan,Tian-Ming Fu,Jia Liu,Charles M Lieber

    Semiconductor nanowires configured as the active channels of field-effect transistors (FETs) have been used as detectors for high-resolution electrical recording from single live cells, cell networks, tissues and organs. Extracellular measurements with substrate supported silicon nanowire (SiNW) FETs, which have projected active areas orders of magnitude smaller than conventional microfabricated multielectrode arrays (MEAs) and planar FETs, recorded action potential and field potential signals with high signal-to-noise ratio and temporal resolution from cultured neurons, cultured cardiomyocytes, acute brain slices and whole animal hearts. Measurements made with modulation-doped nanoscale active channel SiNW FETs demonstrate that signals recorded from cardiomyocytes are highly localized and have improved time resolution compared to larger planar detectors. In addition, several novel three-dimensional (3D) transistor probes, which were realized using advanced nanowire synthesis methods, have been implemented for intracellular recording. These novel probes include (i) flexible 3D kinked nanowire FETs, (ii) branched intracellular nanotube SiNW FETs, and (iii) active silicon nanotube FETs. Following phospholipid modification of the probes to mimic the cell membrane, the kinked nanowire, branched intracellular nanotube and active silicon nanotube FET probes recorded full-amplitude intracellular action potentials from spontaneously firing cardiomyocytes. Moreover, these probes demonstrated the capability of reversible, stable, and long-term intracellular recording, thus indicating the minimal invasiveness of the new nanoscale structures and suggesting biomimetic internalization via the phospholipid modification. Simultaneous, multi-site intracellular recording from both single cells and cell networks were also readily achieved by interfacing independently addressable nanoprobe devices with cells. Finally, electronic and biological systems have been seamlessly merged in 3D for the first time using macroporous nanoelectronic scaffolds that are analogous to synthetic tissue scaffold and the extracellular matrix in tissue. Free-standing 3D nanoelectronic scaffolds were cultured with neurons, cardiomyocytes and smooth muscle cells to yield electronically-innervated synthetic or 'cyborg' tissues. Measurements demonstrate that innervated tissues exhibit similar cell viability as with conventional tissue scaffolds, and importantly, demonstrate that the real-time response to drugs and pH changes can be mapped in 3D through the tissues. These results open up a new field of research, wherein nanoelectronics are merged with biological systems in 3D thereby providing broad opportunities, ranging from a nanoelectronic/tissue platform for real-time pharmacological screening in 3D to implantable 'cyborg' tissues enabling closed-loop monitoring and treatment of diseases. Furthermore, the capability of high density scale-up of the above extra- and intracellular nanoscopic probes for action potential recording provide important tools for large-scale high spatio-temporal resolution electrical neural activity mapping in both 2D and 3D, which promises to have a profound impact on many research areas, including the mapping of activity within the brain.

    更新日期:2019-11-01
  • Nonporous Silica Nanoparticles for Nanomedicine Application.
    Nano Today (IF 16.582) Pub Date : 2013-09-03
    Li Tang,Jianjun Cheng

    Nanomedicine, the use of nanotechnology for biomedical applications, has potential to change the landscape of the diagnosis and therapy of many diseases. In the past several decades, the advancement in nanotechnology and material science has resulted in a large number of organic and inorganic nanomedicine platforms. Silica nanoparticles (NPs), which exhibit many unique properties, offer a promising drug delivery platform to realize the potential of nanomedicine. Mesoporous silica NPs have been extensively reviewed previously. Here we review the current state of the development and application of nonporous silica NPs for drug delivery and molecular imaging.

    更新日期:2019-11-01
  • Materials by Design: Merging Proteins and Music.
    Nano Today (IF 16.582) Pub Date : 2013-09-03
    Joyce Y Wong,John McDonald,Micki Taylor-Pinney,David I Spivak,David L Kaplan,Markus J Buehler

    Tailored materials with tunable properties are crucial for applications as biomaterials, for drug delivery, as functional coatings, or as lightweight composites. An emerging paradigm in designing such materials is the construction of hierarchical assemblies of simple building blocks into complex architectures with superior properties. We review this approach in a case study of silk, a genetically programmable and processable biomaterial, which, in its natural role serves as a versatile protein fiber with hierarchical organization to provide structural support, prey procurement or protection of eggs. Through an abstraction of knowledge from the physical system, silk, to a mathematical model using category theory, we describe how the mechanism of spinning fibers from proteins can be translated into music through a process that assigns a set of rules that governs the construction of the system. This technique allows one to express the structure, mechanisms and properties of the 'material' in a very different domain, 'music'. The integration of science and art through categorization of structure-property relationships presents a novel paradigm to create new bioinspired materials, through the translation of structures and mechanisms from distinct hierarchical systems and in the context of the limited number of building blocks that universally governs these systems.

    更新日期:2019-11-01
  • Anthracycline Nano-Delivery Systems to Overcome Multiple Drug Resistance: A Comprehensive Review.
    Nano Today (IF 16.582) Pub Date : 2013-07-28
    Ping Ma,Russell J Mumper

    Anthracyclines (doxorubicin, daunorubicin, and idarubicin) are very effective chemotherapeutic drugs to treat many cancers; however, the development of multiple drug resistance (MDR) is one of the major limitations for their clinical applications. Nano-delivery systems have emerged as the novel cancer therapeutics to overcome MDR. Up until now, many anthracycline nano-delivery systems have been developed and reported to effectively circumvent MDR both in-vitro and in-vivo, and some of these systems have even advanced to clinical trials, such as the HPMA-doxorubicin (HPMA-DOX) conjugate. Doxil, a DOX PEGylated liposome formulation, was developed and approved by FDA in 1995. Unfortunately, this formulation does not address the MDR problem. In this comprehensive review, more than ten types of developed anthracycline nano-delivery systems to overcome MDR and their proposed mechanisms are covered and discussed, including liposomes; polymeric micelles, conjugate and nanoparticles; peptide/protein conjugates; solid-lipid, magnetic, gold, silica, and cyclodextrin nanoparticles; and carbon nanotubes.

    更新日期:2019-11-01
  • Theranostic agents for intracellular gene delivery with spatiotemporal imaging.
    Nano Today (IF 16.582) Pub Date : 2013-04-23
    Jennifer M Knipe,Jonathan T Peters,Nicholas A Peppas

    Gene therapy is the modification of gene expression to treat a disease. However, efficient intracellular delivery and monitoring of gene therapeutic agents is an ongoing challenge. Use of theranostic agents with suitable targeted, controlled delivery and imaging modalities has the potential to greatly advance gene therapy. Inorganic nanoparticles including magnetic nanoparticles, gold nanoparticles, and quantum dots have been shown to be effective theranostic agents for the delivery and spatiotemporal tracking of oligonucleotides in vitro and even a few cases in vivo. Major concerns remain to be addressed including cytotoxicity, particularly of quantum dots; effective dosage of nanoparticles for optimal theranostic effect; development of real-time in vivo imaging; and further improvement of gene therapy efficacy.

    更新日期:2019-11-01
  • Solid-State and Biological Nanopore for Real-Time Sensing of Single Chemical and Sequencing of DNA.
    Nano Today (IF 16.582) Pub Date : 2013-03-19
    Farzin Haque,Jinghong Li,Hai-Chen Wu,Xing-Jie Liang,Peixuan Guo

    Sensitivity and specificity are two most important factors to take into account for molecule sensing, chemical detection and disease diagnosis. A perfect sensitivity is to reach the level where a single molecule can be detected. An ideal specificity is to reach the level where the substance can be detected in the presence of many contaminants. The rapidly progressing nanopore technology is approaching this threshold. A wide assortment of biomotors and cellular pores in living organisms perform diverse biological functions. The elegant design of these transportation machineries has inspired the development of single molecule detection based on modulations of the individual current blockage events. The dynamic growth of nanotechnology and nanobiotechnology has stimulated rapid advances in the study of nanopore based instrumentation over the last decade, and inspired great interest in sensing of single molecules including ions, nucleotides, enantiomers, drugs, and polymers such as PEG, RNA, DNA, and polypeptides. This sensing technology has been extended to medical diagnostics and third generation high throughput DNA sequencing. This review covers current nanopore detection platforms including both biological pores and solid state counterparts. Several biological nanopores have been studied over the years, but this review will focus on the three best characterized systems including α-hemolysin and MspA, both containing a smaller channel for the detection of single-strand DNA, as well as bacteriophage phi29 DNA packaging motor connector that contains a larger channel for the passing of double stranded DNA. The advantage and disadvantage of each system are compared; their current and potential applications in nanomedicine, biotechnology, and nanotechnology are discussed.

    更新日期:2019-11-01
  • Toxicology and clinical potential of nanoparticles.
    Nano Today (IF 16.582) Pub Date : 2013-01-08
    Lara Yildirimer,Nguyen T K Thanh,Marilena Loizidou,Alexander M Seifalian

    In recent years, nanoparticles (NPs) have increasingly found practical applications in technology, research and medicine. The small particle size coupled to their unique chemical and physical properties is thought to underlie their exploitable biomedical activities. Here, we review current toxicity studies of NPs with clinical potential. Mechanisms of cytotoxicity are discussed and the problem of extrapolating knowledge gained from cell-based studies into a human scenario is highlighted. The so-called 'proof-of-principle' approach, whereby ultra-high NP concentrations are used to ensure cytotoxicity, is evaluated on the basis of two considerations; firstly, from a scientific perspective, the concentrations used are in no way related to the actual doses required which, in many instances, discourages further vital investigations. Secondly, these inaccurate results cast doubt on the science of nanomedicine and thus, quite dangerously, encourage unnecessary alarm in the public. In this context, the discrepancies between in vitro and in vivo results are described along with the need for a unifying protocol for reliable and realistic toxicity reports.

    更新日期:2019-11-01
  • Odyssey of a cancer nanoparticle: from injection site to site of action.
    Nano Today (IF 16.582) Pub Date : 2012-12-18
    Joseph W Nichols,You Han Bae

    No chemotherapeutic drug can be effective until it is delivered to its target site. Nano-sized drug carriers are designed to transport therapeutic or diagnostic materials from the point of administration to the drug's site of action. This task requires the nanoparticle carrying the drug to complete a journey from the injection site to the site of action. The journey begins with the injection of the drug carrier into the bloodstream and continues through stages of circulation, extravasation, accumulation, distribution, endocytosis, endosomal escape, intracellular localization and-finally-action. Effective nanoparticle design should consider all of these stages to maximize drug delivery to the entire tumor and effectiveness of the treatment.

    更新日期:2019-11-01
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
2020新春特辑
限时免费阅读临床医学内容
ACS材料视界
科学报告最新纳米科学与技术研究
清华大学化学系段昊泓
自然科研论文编辑服务
中国科学院大学楚甲祥
上海纽约大学William Glover
中国科学院化学研究所
课题组网站
X-MOL
北京大学分子工程苏南研究院
华东师范大学分子机器及功能材料
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug