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Curcumin-enriched Gemini surfactant nanoparticles exhibited tumoricidal effects on human 3D spheroid HT-29 cells in vitro Cancer Nanotechnol. (IF 4.7) Pub Date : 2021-01-06 Zohre Zibaei; Esmaeil Babaei; Arezoo Rezaie Nezhad Zamani; Reza Rahbarghazi; Hewa Jalal Azeez
Here, we examined the tumoricidal effect of Gemini surfactant nanoparticles enriched with curcumin on 3D spheroid HT-29 cells. The delivery of curcumin and other phytocompounds to the tumor niche is an important challenge. Spheroid HT-29 cells were generated by using a conventional hanging drop method and exposed to different concentrations of Gemini-curcumin nanoparticles. The changes in spheroid
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Graphene oxide nanofilm and chicken embryo extract decrease the invasiveness of HepG2 liver cancer cells Cancer Nanotechnol. (IF 4.7) Pub Date : 2021-01-06 Malwina Sosnowska; Marta Kutwin; Barbara Strojny; Piotr Koczoń; Jarosław Szczepaniak; Jaśmina Bałaban; Karolina Daniluk; Sławomir Jaworski; André Chwalibog; Wiesław Bielawski; Ewa Sawosz
The extracellular matrix (ECM) is a mosaic of various structural and functional proteins that cooperate with the cell, regulate adhesion, and consequently manage its further fate. Liver destruction is accompanied by a disruption of the physicochemical properties of the ECM which deregulates the cell–ECM interaction and can lead to uncontrolled proliferation and neoplastic transformation of cells. Therefore
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Experimental conditions influence the formation and composition of the corona around gold nanoparticles Cancer Nanotechnol. (IF 4.7) Pub Date : 2021-01-06 Md. Nazir Hossen; Chandra Kumar Elechalawar; Virginie Sjoelund; Kathleen Moore; Robert Mannel; Resham Bhattacharya; Priyabrata Mukherjee
Ovarian cancer is one of the deadliest gynecological malignancies. While the overall survival of ovarian cancer patients has slightly improved in recent years in the developed world, it remains clinically challenging due to its frequent late diagnosis and the lack of reliable diagnostic and/or prognostic markers. The aim of this study was to identify potential new molecular target proteins (NMTPs)
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Nanomedicine-mediated induction of immunogenic cell death and prevention of PD-L1 overexpression for enhanced hepatocellular carcinoma therapy Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-12-14 Hanzhang Zhu; Weijiang Zhou; Yafeng Wan; Ke Ge; Jun Lu; Changku Jia
The present study aims to develop a nanoparticle encapsulating doxorubicin (DOX) and programmed death-ligand 1 (PD-L1) siRNA and evaluate its anti-tumor effects on hepatoma carcinoma (HCC). Nanoparticle encapsulating DOX and PD-L1 siRNA (NPDOX/siPD-L1) was characterized by dynamic light scattering and transmission electron microscopy. Flow cytometry was applied to analyze cell populations, NPDOX/siPD-L1
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Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-11-25 S. Pisano; X. Wang; J. Garcia-Parra; A. Gazze; K. Edwards; V. Feltracco; Y. Hu; L. He; D. Gonzalez; L. W. Francis; R. S. Conlan; C. Li
Amphiphilic block copolymers used as nanomicelle drug carriers can effectively overcome poor drug solubility and specificity issues. Hence, these platforms have a broad applicability in cancer treatment. In this study, Pluronic F127 was used to fabricate nanomicelles containing the histone deacetylase inhibitor SAHA, which has an epigenetic-driven anti-cancer effect in several tumor types. SAHA-loaded
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Synthesis and analysis of silver–copper alloy nanoparticles of different ratios manifest anticancer activity in breast cancer cells Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-11-25 Sara Al Tamimi; Sarmadia Ashraf; Tahir Abdulrehman; Aijaz Parray; Said A. Mansour; Yousef Haik; Shahnaz Qadri
Breast cancer is therapeutically very challenging to treat as it has the main four known genetic alterations, which result in the existence of several phenotypes leading to the difference in the mode of therapy and with poor outcome. Metallic nanoparticles of silver or copper have been studied previously as anticancer agents in breast cancer and other types of cancers. However, the anticancer effect
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Nanotechnology approaches to addressing HER2-positive breast cancer Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-10-17 Bryan E. White; Molly K. White; Het Adhvaryu; Issam Makhoul; Zeid A. Nima; Alexandru S. Biris; Nawab Ali
Breast cancer is a major cause of cancer-associated deaths in the United States. It was estimated that 12% of women in the U.S. will develop invasive breast cancer in their lifetime. The human epidermal growth factor receptor (HER2/neu) is a growth-promoting protein that is overexpressed in 15–20% of breast cancers (HER2-positive breast cancer). HER2-positive breast cancer generally grows and spreads
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Algae-meditated route to cuprous oxide (Cu2O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-10-14 Parisa Taherzadeh-Soureshjani; Mohammad Chehelgerdi
Breast cancer (BC), as the most widely recognized disease in women worldwide, represents about 30% of all cancers impacting women. This study was aimed to synthesize Cu2O nanoparticles from the cystoseira myrica algae (CM-Cu2O NPs) assess their antimicrobial activity against pathogenic bacteria and fungi. We evaluated the expression levels of lncRNAs (MALAT1 and GAS5) and apoptosis genes (p53, p27
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Cockle shell-derived aragonite calcium carbonate nanoparticle for targeting cancer and breast cancer stem cells Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-10-07 Kehinde Muibat Ibiyeye; Sherifat Banke Idris; Abu Bakar Zakaria Zuki
Cockle shell-derived aragonite calcium carbonate nanoparticles (CACNP) have demonstrated prospect as nano-sized drug carriers for targeting cancer cells. CACNP is biocompatible, biodegradable and its biomaterial is readily available and is of low cost. In addition, CACNP is highly porous, has a large surface area which confer a high loading capacity. The pH-dependent release properties as well as its
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Enhanced MRI-guided radiotherapy with gadolinium-based nanoparticles: preclinical evaluation with an MRI-linac Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-10-06 H. L. Byrne; G. Le Duc; F. Lux; O. Tillement; N. M. Holmes; A. James; U. Jelen; B. Dong; G. Liney; T. L. Roberts; Z. Kuncic
The AGuIX® (NH TherAguix) nanoparticle has been developed to enhance radiotherapy treatment and provide strong MR contrast. These two properties have previously been investigated separately and progressed to clinical trial following a clinical workflow of separate MR imaging followed some time later by radiotherapy treatment. The recent development of MRI-linacs (combined Magnetic Resonance Imaging–linear
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Elucidating the fate of nanoparticles among key cell components of the tumor microenvironment for promoting cancer nanotechnology. Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-08-18 Kyle Bromma,Aaron Bannister,Antonia Kowalewski,Leah Cicon,Devika B Chithrani
Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME), such as normal fibroblasts (FBs) and cancer-associated FBs (CAFs). So far, much focus has been on cancer cells, but FBs and CAFs also play a critical
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Cancer research, treatment, and COVID-19. Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-08-06 Steven A Curley,Frederick Currell,Sunil Krishnan,Zeljka Krpetic
The COVID-19 pandemic has radically changed the world we live in. The novel coronavirus SARS-CoV-2, the infectious agent that causes the disease, is believed to have first appeared around December 2019, and in the months since then it has wreaked havoc on human communities, health systems, and economies worldwide. At the time of writing, it is estimated that more than 12 million individuals have been
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Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-07-01 Rahul A. Sheth; Xiaoxia Wen; Junjie Li; Marites P. Melancon; Xin Ji; Y. Andrew Wang; Cheng-Hui Hsiao; Diana S.-L. Chow; Elizabeth M. Whitley; Chun Li; Sanjay Gupta
Doxorubicin-loaded hollow gold nanospheres (Dox@HAuNS) are a promising technology for simultaneous trans-arterial tumor-targeted chemotherapy delivery and thermal ablation. We evaluated the efficacy of intra-arterial delivery of Dox@HAuNS followed by photothermal ablation (PTA) in a rabbit model of liver cancer. Adult New Zealand white rabbits (N = 25) were inoculated with VX2 tumors into the left
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Comparative study on contrast enhancement of Magnevist and Magnevist-loaded nanoparticles in pancreatic cancer PDX model monitored by MRI. Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-05-14 Kevin Affram,Taylor Smith,Shannon Helsper,Jens T Rosenberg,Bo Han,Jose Trevino,Edward Agyare
The aim of this study was to compare contrast enhancement of Magnevist® (gadopentate dimeglumine (Mag)) to that of PEGylated Magnevist®-loaded liposomal nanoparticles (Mag-Lnps) in pancreatic cancer patient-derived xenograft (PDX) mouse model via magnetic resonance imaging (MRI). Mag-Lnps formulated by thin-film hydration and extrusion was characterized for the particle size and zeta potential. A 21
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Reducing the effective dose of cisplatin using gold nanoparticles as carriers Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-03-30 M. A. González-López; E. M. Gutiérrez-Cárdenas; C. Sánchez-Cruz; J. F. Hernández-Paz; I. Pérez; J. J. Olivares-Trejo; O. Hernández-González
Nanotechnology is a frequent treatment for cancer. Nanomaterials are the vehicles which deliver drugs in smaller but equally effective quantities. The aim of this investigation is to synthesize gold nanoparticles, functionalize them for the transportation of cisplatin and release them to the cancer-affected area. They have the same cytotoxicity as conventional treatments but with the smallest effective
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Preferential drug delivery to tumor cells than normal cells using a tunable niosome–chitosan double package nanodelivery system: a novel in vitro model Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-03-30 Marzenna Wiranowska; Rupin Singh; Rana Falahat; Eva Williams; Joseph O. Johnson; Norma Alcantar
We previously described the properties of a targeted drug delivery system (DDS) in a cell-free system. Here, in this comparative cell-based study (normal and tumor cells), we provide a quantitative analysis of the extracellular diffusion and intracellular localization of this DDS. This DDS consists of fluorescence-labeled paclitaxel encapsulated in non-ionic surfactant vesicles/niosomes embedded in
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A [60]fullerene nanoconjugate with gemcitabine: synthesis, biophysical properties and biological evaluation for treating pancreatic cancer Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-02-18 Paweł Nalepa; Robert Gawecki; Grzegorz Szewczyk; Katarzyna Balin; Mateusz Dulski; Mieczysław Sajewicz; Anna Mrozek-Wilczkiewicz; Robert Musioł; Jaroslaw Polanski; Maciej Serda
The first-line chemotherapy drug that is used to treat pancreatic ductal adenocarcinoma is gemcitabine. Unfortunately, its effectiveness is hampered by its chemo-resistance, low vascularization and drug biodistribution limitations in the tumor microenvironment. Novel nanotherapeutics must be developed in order to improve the prognosis for patients with pancreatic cancer. We developed a synthetic methodology
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Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplications Cancer Nanotechnol. (IF 4.7) Pub Date : 2020-01-09 Vladimir Gubala; Giorgia Giovannini; Filip Kunc; Marco P. Monopoli; Colin J. Moore
Fluorescent silica nanoparticles have been extensively utilised in a broad range of biological applications and are facilitated by their predictable, well-understood, flexible chemistry and apparent biocompatibility. The ability to couple various siloxane precursors with fluorescent dyes and to be subsequently incorporated into silica nanoparticles has made it possible to engineer these fluorophores-doped
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Nanomedicine review: clinical developments in liposomal applications Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-12-19 Esteban Beltrán-Gracia; Adolfo López-Camacho; Inocencio Higuera-Ciapara; Jesús B Velázquez-Fernández; Alba A Vallejo-Cardona
In recent years, disease treatment has evolved strategies that require increase in pharmaceutical agent’s efficacy and selectivity while decreasing their toxicity in normal tissues. These requirements have led to the development of nanoscale liposome systems for drug release. This review focuses on lipid features, pharmacological properties of liposomal formulations and the clinical studies of their
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A comparison of the radiosensitisation ability of 22 different element metal oxide nanoparticles using clinical megavoltage X-rays Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-12-19 Alexandra Guerreiro; Nicholas Chatterton; Eleanor M. Crabb; Jon P. Golding
A wide range of nanoparticles (NPs), composed of different elements and their compounds, are being developed by several groups as possible radiosensitisers, with some already in clinical trials. However, no systematic experimental survey of the clinical X-ray radiosensitising potential of different element nanoparticles has been made. Here, we directly compare the irradiation-induced (10 Gy of 6-MV
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Science vs. technology in radiation therapy from X-rays to ions Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-10-31 Eugene Surdutovich; Andrey V Solov’yov
In general, science and technology march in their ways, sometimes starting at different times and developing at different paces. Radiation therapy as an application of ionizing radiation to treat tumors by inactivating cells is a good example of this notion. Brachytherapy, a cancer treatment performed by placing a radioactive source in the direct vicinity of the tumor, was independently suggested by
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Effects and side effects of plasmonic photothermal therapy in brain tissue Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-10-24 Yue He; Kristoffer Laugesen; Dana Kamp; Salik A. Sultan; Lene B. Oddershede; Liselotte Jauffred
Heat generated from plasmonic nanoparticles can be utilized in plasmonic photothermal therapy. A combination of near-infrared laser and plasmonic nanoparticles is compelling for the treatment of brain cancer, due to the efficient light-to-heat conversion and bio-compatibility. However, one of the challenges of plasmonic photothermal therapy is to minimize the damage of the surrounding brain tissue
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Comparison of the effect of rhodium citrate-associated iron oxide nanoparticles on metastatic and non-metastatic breast cancer cells Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-09-11 Natalia Lemos Chaves; Danilo Aquino Amorim; Cláudio Afonso Pinho Lopes; Irina Estrela-Lopis; Julia Böttner; Aparecido Ribeiro de Souza; Sônia Nair Báo
Nanocarriers have the potential to improve the therapeutic index of currently available drugs by increasing drug efficacy, lowering drug toxicity and achieving steady-state therapeutic levels of drugs over an extended period. The association of maghemite nanoparticles (NPs) with rhodium citrate (forming the complex hereafter referred to as MRC) has the potential to increase the specificity of the cytotoxic
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Multiscale modeling for cancer radiotherapies Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-08-22 Eugene Surdutovich; Andrey V. Solov’yov
Ion-beam cancer therapy, an alternative to a common radiation therapy with X-rays, has been used clinically around the world since 1990s; the number of proton therapy centers as well as facilities using heavier ions such as α-particles and carbon ions continues to grow. A number of different methods were used by various scientific communities in order to quantitatively predict therapeutic effects of
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The role of shock waves on the biodamage induced by ion beam radiation Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-07-30 Pablo de Vera; Eugene Surdutovich; Andrey V. Solov’yov
Energetic ions irradiate the human body in different situations such as exposure to galactic cosmic rays and ion beam cancer therapy. Ions propagating through dense medium deposit energy on the nanometre scale, which cause large local doses in their tracks. This makes the mechanisms of the following biodamage different from that induced by photons. A distinctive feature of the scenario of radiation
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Phenomenon-based evaluation of relative biological effectiveness of ion beams by means of the multiscale approach Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-05-23 Alexey Verkhovtsev; Eugene Surdutovich; Andrey V. Solov’yov
Relative biological effectiveness (RBE) is a key quantity for the description of radiobiological effects induced by charged-particle irradiation in the context of ion-beam cancer therapy. Since RBE is a complex function that depends on different physical, chemical, and biological parameters, a fundamental understanding of radiobiological effects becomes increasingly important for clinical applications
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Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O2 and radiosensitization by nanoparticles Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-05-13 Gérard Baldacchino; Emilie Brun; Ibtihel Denden; Sarah Bouhadoun; Raphael Roux; Hicham Khodja; Cécile Sicard-Roselli
This article reviews radiation chemistry processes induced by high-linear energy transfer (LET) radiation. The first part gives a short historical introduction and defines the essential concepts of radiation chemistry. It is aimed at radiobiologists in search of basics in this discipline, to link to their biological observations. Then, special focus is done on LET effect, oxygen effect and nanoparticles
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In vitro anticancer activity of folate-modified docetaxel-loaded PLGA nanoparticles against drug-sensitive and multidrug-resistant cancer cells Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-05-13 Yuri I. Poltavets; Alexander S. Zhirnik; Vasilisa V. Zavarzina; Yuliya P. Semochkina; Valentina G. Shuvatova; Anna A. Krasheninnikova; Sergey V. Aleshin; Danil O. Dronov; Eugeny A. Vorontsov; Vadim Yu. Balabanyan; Galina A. Posypanova
Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer which is widely used as a matrix to incorporate therapeutic agents. The anticancer activity of targeted folate-modified docetaxel-loaded PLGA nanoparticles (F–NP–Doc) was studied in vitro. Nanoparticles were prepared by a single-emulsion solvent-evaporation technique and characterized by physico-chemical methods. Cell
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Use of a lipid nanoparticle system as a Trojan horse in delivery of gold nanoparticles to human breast cancer cells for improved outcomes in radiation therapy Cancer Nanotechnol. (IF 4.7) Pub Date : 2019-04-25 Kyle Bromma; Kristy Rieck; Jayesh Kulkarni; Connor O’Sullivan; Wonmo Sung; Pieter Cullis; Jan Schuemann; Devika B. Chithrani
Radiotherapy is commonly used for treating cancer. Novel sensitizers, such as gold nanoparticles (GNPs), are being used to enhance the local radiation dose. It is not known how the uptake and radiation dose enhancement of GNPs vary in synchronized vs unsynchronized (control) tumor cell populations. Successful application of GNPs in radiation therapy requires NPs to be accumulated within individual
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Comb-like PEG-containing polymeric composition as low toxic drug nanocarrier. Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-12-20 Lesya Kobylinska,Igor Patereha,Natalia Finiuk,Natalia Mitina,Anna Riabtseva,Igor Kotsyumbas,Rostyslav Stoika,Alexander Zaichenko,Sandor G Vari
Development of biocompatible multifunctional polymeric drug carriers is crucial in modern pharmaceutics aimed to create “smart” drugs. The high potential of the PEGylated comb-like polymeric nanocarrier (PNC) in delivering both traditional and experimental drugs to tumor cells in vitro and in vivo has been demonstrated previously. In the present study, we investigated the general toxicity of polyethylene
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Enhanced nanoparticle delivery exploiting tumour-responsive formulations. Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-11-21 Lindsey A Bennie,Helen O McCarthy,Jonathan A Coulter
Nanoparticles can be used as drug carriers, contrast agents and radiosensitisers for the treatment of cancer. Nanoparticles can either passively accumulate within tumour sites, or be conjugated with targeting ligands to actively enable tumour deposition. With respect to passive accumulation, particles < 150 nm accumulate with higher efficiency within the tumour microenvironment, a consequence of the
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Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents: the Relative Biological Effective Dose (RBED) framework. Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-11-09 Jeremy M C Brown,Gerard G Hanna,Nathanael Lampe,Balder Villagomez-Bernabe,James R Nicol,Jonathan A Coulter,Fred J Currell
A novel treatment planning framework, the Relative Biological Effective Dose (RBED), for high Z nanoparticle (NP)-enhanced photon radiotherapy is developed and tested in silico for the medical exemplar of neoadjuvant (preoperative) breast cancer MV photon radiotherapy. Two different treatment scenarios, conventional and high Z NP enhanced, were explored with a custom Geant4 application that was developed
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C60 fullerene and its nanocomplexes with anticancer drugs modulate circulating phagocyte functions and dramatically increase ROS generation in transformed monocytes. Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-10-31 Larysa M Skivka,Svitlana V Prylutska,Mariia P Rudyk,Nataliia M Khranovska,Ievgeniia V Opeida,Vasyl V Hurmach,Yuriy I Prylutskyy,Leonid F Sukhodub,Uwe Ritter
C60 fullerene-based nanoformulations are proposed to have a direct toxic effect on tumor cells. Previous investigations demonstrated that C60 fullerene used alone or being conjugated with chemotherapeutic agents possesses a potent anticancer activity. The main aim of this study was to investigate the effect of C60 fullerene and its nanocomplexes with anticancer drugs on human phagocyte metabolic profile
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Magnetic hyperthermia of breast cancer cells and MRI relaxometry with dendrimer-coated iron-oxide nanoparticles. Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-10-08 Marzieh Salimi,Saeed Sarkar,Reza Saber,Hamid Delavari,Ali Mohammad Alizadeh,Hendrik Thijmen Mulder
Recently, some studies have focused on dendrimer nanopolymers as a magnetic resonance imaging (MRI) contrast agent or a vehicle for gene and drug delivery. Considering the suitable properties of these materials, they are appropriate candidates for coating iron-oxide nanoparticles which are applied in magnetic hyperthermia. To the best of our knowledge, the novelty of this study is the investigation
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Cisplatin-loaded hollow gold nanoparticles for laser-triggered release. Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-08-03 Chiyi Xiong,Wei Lu,Min Zhou,Xiaoxia Wen,Chun Li
Hollow gold nanoparticles (HGNPs) exposed to near-infrared (NIR) light yield photothermal effects that can trigger a variety of biological effects for potential biomedical applications. However, the mechanism of laser-triggered drug release has not been studied before. A tripeptide Ac-Glu-Glu-Cys-NH2 (Ac-EEC) was directly linked to the surface of HGNPs. The EEC-HGNPs conjugate was then complexed with
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Gene therapy with RALA/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer. Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-06-01 Cian M McCrudden,John W McBride,Joanne McCaffrey,Emma M McErlean,Nicholas J Dunne,Vicky L Kett,Jonathan A Coulter,Tracy Robson,Helen O McCarthy
Recent approvals of gene therapies by the FDA and the EMA for treatment of inherited disorders have further opened the door for assessment of nucleic acid pharmaceuticals for clinical usage. Arising from the presence of damaged or inappropriate DNA, cancer is a condition particularly suitable for genetic intervention. The RALA peptide has been shown to be a potent non-viral delivery platform for nucleic
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Gold nanoparticle mediated combined cancer therapy Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-05-02 Celina Yang; Kyle Bromma; Caterina Di Ciano-Oliveira; Gaetano Zafarana; Monique van Prooijen; Devika B. Chithrani
The combined use of radiation therapy and chemotherapy is commonly being used in cancer treatment. The side effects of the treatment can be further minimized through targeted delivery of anticancer drugs and local enhancement of the radiation dose. Gold nanoparticles (GNPs) can play a significant role in this regard since GNPs can be used as radiation dose enhancers and anticancer drug carriers. Anticancer
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Antiangiogenic and antiapoptotic effects of green-synthesized zinc oxide nanoparticles using Sargassum muticum algae extraction. Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-04-02 Zahra Sanaeimehr,Iraj Javadi,Farideh Namvar
Algae are one of the natural materials used to green synthesis of nanoparticles. This method leads to minimize the toxicity of the chemical materials used to nanoparticle synthesis. In this study, zinc oxide nanoparticles (ZnO NPs) synthesized by Sargassum muticum algae extraction used to evaluate its cytotoxicity and apoptotic properties on human liver cancer cell line (HepG2). Trypan blue assay results
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Important parameters for optimized metal nanoparticles-aided electromagnetic field (EMF) effect on cancer. Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-03-15 Lawrence Ochoo,Charles Migwi,John Okumu
A number of experimental research findings for the metal nanoparticles (NPs)-mediated EMF photothermal therapy of cancer cells show an intriguing trend of the NPs’ size-dependent efficacy. This is a phenomenon we find to trend with the light absorption bandwidth behavior (full width at half maximum) of the NPs and the accompanying electric field enhancement. We find that the nanoparticle sizes that
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The study of toxicity and pathogenicity risk of Potato Virus X/Herceptin nanoparticles as agents for cancer therapy Cancer Nanotechnol. (IF 4.7) Pub Date : 2018-01-29 Neda Esfandiari; Mohsen Karimi Arzanani; Mina Koohi-Habibi
Nowadays, viral nanoparticles (VNPs) have attracted a lot of attention, although some are concerned that VNPs may reflect on viral entry of virus into animal or plant cells. In the present study, it aimed to investigate the pathogenesis of VNPs formed by Herceptin (Trastuzumab) and the viral nanoparticles derived from the filamentous plant virus Potato Virus X (PVX-HER) in host plant. Flow cytometry
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Electrochemical and optical biosensors for early-stage cancer diagnosis by using graphene and graphene oxide. Cancer Nanotechnol. (IF 4.7) Pub Date : 2017-12-11 Aditya Balaji,Jin Zhang
Conventional instruments for cancer diagnosis including magnetic resonance imaging, computed tomography scan, are expensive and require long-waiting time, whilst the outcomes have not approached to the successful early-stage diagnosis yet. Due to the special properties of graphene-based nanocomposites, e.g., good electrical and thermal conductivity, luminescence, and mechanic flexibility, these ultra-thin
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Particle therapy and nanomedicine: state of art and research perspectives. Cancer Nanotechnol. (IF 4.7) Pub Date : 2017-11-21 Sandrine Lacombe,Erika Porcel,Emanuele Scifoni
Cancer radiation therapy with charged particle beams, called particle therapy, is a new therapeutic treatment presenting major advantages when compared to conventional radiotherapy. Because ions have specific ballistic properties and a higher biological effectiveness, they are superior to x-rays. Numerous medical centres are starting in the world using mostly protons but also carbon ions as medical
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From basics to clinic: Cancer Nanotechnology. Cancer Nanotechnol. (IF 4.7) Pub Date : 2017-11-10 Fred Currell,Steven Curley,Željka Krpetić,Mark Bellringer
Cancer is a group of diseases driven by inherently nanostructural problems (e.g. DNA issues). As such, there are obvious benefits to treatments employing nanoscale structures and processes. Additionally, as nanotechnologies are developing at a rapid rate, it is likely that many new themes will develop within the area in the next few years. With this in mind, Cancer Nanotechnology aims to provide a
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Cancer resistance to treatment and antiresistance tools offered by multimodal multifunctional nanoparticles. Cancer Nanotechnol. (IF 4.7) Pub Date : 2017-10-26 Eudald Casals,Muriel F Gusta,Macarena Cobaleda-Siles,Ana Garcia-Sanz,Victor F Puntes
Chemotherapeutic agents have limited efficacy and resistance to them limits today and will limit tomorrow our capabilities of cure. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours. In front of this, multimodality has appeared as a promising strategy to overcome resistance. In
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The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy. Cancer Nanotechnol. (IF 4.7) Pub Date : 2017-10-19 Zahraa Youssef,Régis Vanderesse,Ludovic Colombeau,Francis Baros,Thibault Roques-Carmes,Céline Frochot,Habibah Wahab,Joumana Toufaily,Tayssir Hamieh,Samir Acherar,Amirah Mohd Gazzali
Nanoparticles (NPs) have been shown to have good ability to improve the targeting and delivery of therapeutics. In the field of photodynamic therapy (PDT), this targeting advantage of NPs could help ensure drug delivery at specific sites. Among the commonly reported NPs for PDT applications, NPs from zinc oxide, titanium dioxide, and fullerene are commonly reported. In addition, graphene has also been
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Cancer characterization and diagnosis with SERS-encoded particles Cancer Nanotechnol. (IF 4.7) Pub Date : 2017-10-18 Luca Guerrini; Nicolas Pazos-Perez; Eduardo Garcia-Rico; Ramon Alvarez-Puebla
Early diagnosis, monitoring and treatment selection of cancer represent major challenges in medicine. The definition of the complex clinical and molecular landscape of cancer requires the combination of multiple techniques and the investigation of multiple targets. As a result, diagnosis is normally lengthy, expensive and, in many cases, cannot be performed recursively. In recent years, optical biosensors
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Platinum nanoparticles: an exquisite tool to overcome radioresistance. Cancer Nanotechnol. (IF 4.7) Pub Date : 2017-07-11 Sha Li,Erika Porcel,Hynd Remita,Sergio Marco,Matthieu Réfrégiers,Murielle Dutertre,Fabrice Confalonieri,Sandrine Lacombe
Small metallic nanoparticles are proposed as potential nanodrugs to optimize the performances of radiotherapy. This strategy, based on the enrichment of tumours with nanoparticles to amplify radiation effects in the tumour, aims at increasing the cytopathic effect in tumours while healthy tissue is preserved, an important challenge in radiotherapy. Another major cause of radiotherapy failure is the
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An overview of current practice in external beam radiation oncology with consideration to potential benefits and challenges for nanotechnology. Cancer Nanotechnol. (IF 4.7) Pub Date : 2017-02-03 Raymond B King,Stephen J McMahon,Wendy B Hyland,Suneil Jain,Karl T Butterworth,Kevin M Prise,Alan R Hounsell,Conor K McGarry
Over the past two decades, there has been a significant evolution in the technologies and techniques employed within the radiation oncology environment. Over the same period, extensive research into the use of nanotechnology in medicine has highlighted a range of potential benefits to its incorporation into clinical radiation oncology. This short communication describes key tools and techniques that
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Biological mechanisms of gold nanoparticle radiosensitization. Cancer Nanotechnol. (IF 4.7) Pub Date : 2017-02-02 Soraia Rosa,Chris Connolly,Giuseppe Schettino,Karl T Butterworth,Kevin M Prise
There has been growing interest in the use of nanomaterials for a range of biomedical applications over the last number of years. In particular, gold nanoparticles (GNPs) possess a number of unique properties that make them ideal candidates as radiosensitizers on the basis of their strong photoelectric absorption coefficient and ease of synthesis. However, despite promising preclinical evidence in
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A local effect model-based interpolation framework for experimental nanoparticle radiosensitisation data. Cancer Nanotechnol. (IF 4.7) Pub Date : 2017-01-31 Jeremy M C Brown,Fred J Currell
A local effect model (LEM)-based framework capable of interpolating nanoparticle-enhanced photon-irradiated clonogenic cell survival fraction measurements as a function of nanoparticle concentration was developed and experimentally benchmarked for gold nanoparticle (AuNP)-doped bovine aortic endothelial cells (BAECs) under superficial kilovoltage X-ray irradiation. For three different superficial kilovoltage
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Application of nanotechnology to cancer radiotherapy. Cancer Nanotechnol. (IF 4.7) Pub Date : 2016-12-19 Yu Mi,Zhiying Shao,Johnny Vang,Orit Kaidar-Person,Andrew Z Wang
Radiotherapy has been an integral treatment modality for cancer. The field arose from and progressed through innovations in physics, engineering, and biology. The evolution of radiation oncology will rely on the continued adoption of advances from other fields. A new area of science that possesses the ability to impact radiation oncology is nanomedicine. Materials on the nanoscale provide many unique
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Profiling lung adenocarcinoma by liquid biopsy: can one size fit all? Cancer Nanotechnol. (IF 4.7) Pub Date : 2016-11-22 Harry W Clifford,Amy P Cassidy,Courtney Vaughn,Evaline S Tsai,Bianka Seres,Nirmesh Patel,Hannah L O'Neill,Emil Hewage,John W Cassidy
Cancer is first and foremost a disease of the genome. Specific genetic signatures within a tumour are prognostic of disease outcome, reflect subclonal architecture and intratumour heterogeneity, inform treatment choices and predict the emergence of resistance to targeted therapies. Minimally invasive liquid biopsies can give temporal resolution to a tumour’s genetic profile and allow the monitoring
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Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy. Cancer Nanotechnol. (IF 4.7) Pub Date : 2016-11-16 Jun Zhao,Min Zhou,Chun Li
Radiotherapy has been, and will continue to be, a critical modality to treat cancer. Since the discovery of radiation-induced cytotoxicity in the late 19th century, both external and internal radiation sources have provided tremendous benefits to extend the life of cancer patients. Despite the dramatic improvement of radiation techniques, however, one challenge persists to limit the anti-tumor efficacy
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Gold nanoparticles for cancer radiotherapy: a review. Cancer Nanotechnol. (IF 4.7) Pub Date : 2016-11-03 Kaspar Haume,Soraia Rosa,Sophie Grellet,Małgorzata A Śmiałek,Karl T Butterworth,Andrey V Solov'yov,Kevin M Prise,Jon Golding,Nigel J Mason
Radiotherapy is currently used in around 50% of cancer treatments and relies on the deposition of energy directly into tumour tissue. Although it is generally effective, some of the deposited energy can adversely affect healthy tissue outside the tumour volume, especially in the case of photon radiation (gamma and X-rays). Improved radiotherapy outcomes can be achieved by employing ion beams due to
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Optical fibre sensors: their role in in vivo dosimetry for prostate cancer radiotherapy. Cancer Nanotechnol. (IF 4.7) Pub Date : 2016-10-18 P Woulfe,F J Sullivan,S O'Keeffe
Review is made of dosimetric studies of current optical fibre technology in radiotherapy for therapeutic applications, focusing particularly on in vivo dosimetry for prostate radiotherapy. We present the various sensor designs along with the main advantages and disadvantages associated with this technology. Optical fibres are ideally placed for applications in radiotherapy dosimetry; due to their small
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Trends in targeted prostate brachytherapy: from multiparametric MRI to nanomolecular radiosensitizers. Cancer Nanotechnol. (IF 4.7) Pub Date : 2016-07-04 Alexandru Mihai Nicolae,Niranjan Venugopal,Ananth Ravi
The treatment of localized prostate cancer is expected to become a significant problem in the next decade as an increasingly aging population becomes prone to developing the disease. Recent research into the biological nature of prostate cancer has shown that large localized doses of radiation to the cancer offer excellent long-term disease control. Brachytherapy, a form of localized radiation therapy
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Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields. Cancer Nanotechnol. (IF 4.7) Pub Date : 2016-06-30 Norman A Lapin,Martyna Krzykawska-Serda,Matthew J Ware,Steven A Curley,Stuart J Corr
Poor biodistribution and accumulation of chemotherapeutics in tumors due to limitations on diffusive transport and high intra-tumoral pressures (Jain RK, Nat Med. 7(9):987–989, 2001) have prompted the investigation of adjunctive therapies to improve treatment outcomes. Hyperthermia has been widely applied in attempts to meet this need, but it is limited in its ability to reach tumors in deeply located
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Gazelles, unicorns, and dragons battle cancer through the Nanotechnology Startup Challenge. Cancer Nanotechnol. (IF 4.7) Pub Date : 2016-06-09 Rosemarie Truman,Cody J Locke
On March 4th, 2016, Springer’s Cancer Nanotechnology office promoted the launch of the Nanotechnology Startup Challenge in Cancer (NSC 2 ). This innovation-development model is a partnership among our company, the Center for Advancing Innovation (CAI), MedImmune, the global biologics arm of AstraZeneca, and multiple institutes at the National Institutes of Health (NIH). NSC 2 “crowdsources” talent
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Nanotechnology and cancer: improving real-time monitoring and staging of bladder cancer with multimodal mesoporous silica nanoparticles. Cancer Nanotechnol. (IF 4.7) Pub Date : 2016-04-27 Sean K Sweeney,Yi Luo,Michael A O'Donnell,Jose Assouline
Despite being one of the most common cancers, bladder cancer is largely inefficiently and inaccurately staged and monitored. Current imaging methods detect cancer only when it has reached “visible” size and has significantly disrupted the structure of the organ. By that time, thousands of cells will have proliferated and perhaps metastasized. Repeated biopsies and scans are necessary to determine the
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Cancer Nanotechnology Startup Challenge: a new way to realize the fruits of innovation. Cancer Nanotechnol. (IF 4.7) Pub Date : 2016-03-04 Fred Currell,Mark Bellringer
A significant new innovation-development model is being launched in the field of cancer and nanotechnology. A significant new innovation-development model is being launched in the field of cancer and nanotechnology.
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