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Nanocapsule-Based Reactive Nano-Fragrances with Slow-Release and Antibacterial Performances for Applications of Commodities. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Wenli Wang, Xinyu Qiu, Qiushi Dong, Jingwen Wang, Qiulian Hao, Guiying Liu, Yan Li, Xin Zhang
Fragrances are widely used in everyday life. However, too fast volatilization rates and poor adhesion on substrates limit their applications. In this study, reactive nano-fragrance based on cyanuric chloride (CYC)-modified chitosan (CSCYC) were prepared by a solvent evaporation method. First, CS-CYC was synthesized. Subsequently, CS and CS-CYC were utilized to prepare nano-fragrances. The results demonstrated
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Nano-Hydrogel for the Treatment of Depression and Epilepsy. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Libai Yang
This article first combines nano-carrier technology, the electrophysiological mechanism of seizures, and brain targeting technology to prepare new nano-hydrogels. Secondly, through the discharge information generated during the seizure and the electric field responsiveness of the nano-hydrogel, the free drug concentration in the brain area related to the seizure is increased, thereby, limiting the
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Solid Lipid Nanoparticles Loaded with Nisin (SLN-Nisin) are More Effective Than Free Nisin as Antimicrobial, Antibiofilm, and Anticancer Agents. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Allan Radaic, Erin Malone, Pachiyappan Kamarajan, Yvonne L Kapila
Bacteriocins are peptides produced by bacteria to inhibit the growth of other prokaryotes. Nisin is a bacteriocin widely used in the food industry and for biomedical applications. However, bacteriocins have some limitations, as they experience mechanisms of resistance, degradation by proteases, and suboptimal intracellular delivery. Combining bacteriocins with nanoscale drug delivery systems (nano-DDS)
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Macrophage Membrane-Derived Biomimetic Nanoparticles for Treatment of Cytokine Release Syndrome. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Huirong Jiang, Zongguang Tai, Huijun Pan, Zhen Cui, Rongrong Chai, Congcong Zhu, Jing Tian, Leilei Bao, Quangang Zhu, Zhongjian Chen
Cytokine release syndrome (CRS) is a severe complication of infectious diseases like Coronavirus disease 2019 (COVID-19) that cause serious damage to public health. Currently, supportive therapy is still the main therapeutic strategy exists for CRS treatment. Here, we show the potential of macrophage membrane-derived biomimetic nanoparticles for CRS treatment. By fusing macrophage membrane on the surface
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Targeted Anti-Hepatocellular Carcinoma Research of Targeted Peptides Combined with Drug-Loaded Cell-Derived Microparticles. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Xu Ximei, Luo Yiqun, Zhang Zhikun, Nie Yueli, Liu Xiuli, Shi Wei, Wu Tao, Wu Pan, Liu Xiyu, Huang Yong, Zhao Yongxiang, Gan Lu, Zhong Liping, Chen Qiaoying, He Jian
To conduct an anti-tumor research by using targeted drug-loaded cell-derived microparticles to target the tumor microenvironment and enhance NK cell killing function. In this experiment, we obtained HepG2 tumor cell-derived microparticles by physical extrusion, high speed centrifugation and filtration, modified the hepatocellular carcinoma targeting peptide SP94 on the surface of microparticles and
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Hypoxia-Responsive Molecular Probe Lighted up by Peptide Self-Assembly for Cancer Cell Imaging. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Sifan Ai, Wenhao Dong, Jie Li, Zhimou Yang
Hypoxia is a characteristic feature of most solid tumors, which promotes the proliferation, metastasis, and invasion of tumors and stimulates the resistance of cancer treatments, leading to the serious consequences of tumor recurrence. The exploration of hypoxia detection technology will aid tumor diagnosis and treatment. Fluorescence imaging technology is an accurate and efficient hypoxia detection
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Investigation of Titanium Mesh and Nano-Hydroxyapatite/Polyamide 66 Bone Graft in Cervical Reconstruction of Spondylosis After Sub-Total Vertebral Body Resection. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Chenyu Zong, Jiashang Du, Shenji Lu, Rui Zhou, Miaomiao Zhang, Jianwei Zhu, Jiacheng Xu
The nano-hydroxyapatite/polyamide 66 (n-HA/PA66) bionic bone column, as a high-performance tissue repair and replacement material, introduced as a high osteo-induction ability agent. Nanomaterial has significantly taken a place in orthopedic surgery, however, the efficacy of using n-HA/PA66 is yet to be established. In this regard, this study evaluated various sagittal parameters (such as imaging measurement)
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Formulation Design, Characterization and In-Vivo Assessment of Cefixime Loaded Binary Solid Lipid Nanoparticles to Enhance Oral Bioavailability. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Mahwish Kamran, Mir Azam Khan, Muhammad Shafique, Ghallab Alotaibi, Abdulaziz Al Mouslem, Maqsood Rehman, Muhammad Asghar Khan, Sumaira Gul
Cefixime; widely employed cephalosporin antibiotic is unfortunately coupled to poor water solubility with resultant low oral bioavailability issues. To solve this problem micro-emulsion technique was used to fabricate binary SLNs using blend of solid and liquid lipids, surfactant as well as co-surfactant. The optimized nano suspension was characterized followed by modification to solidified dosage
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Preliminary Study of an Adjustable, Wearable, Noninvasive Vest Providing Chest Compression to Assist with Breathing. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Jianwen Li, Yujiang Li, Huazhu Liu, Shengxin Lin, Haihui Xie, Ruilan Pan, Xueqin Chang, Jianfeng Lu, Songbo Li, Jianping Zhou
Respiratory muscle paralysis caused by acute cervical spinal cord injury usually leads to pulmonary ventilation dysfunction and even death from respiratory failure. In addition to invasive treatments such as mechanical ventilation, the utilization of noninvasive respiratory support equipment plays an important role in long-term assisted breathing. In this study, we describes a wearable, noninvasive
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Novel Bioengineered Antibacterial and Anticancer ZnO Nanoparticles. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Helal F Al-Harthi, Abu Baker, Abdallah M Elgorban, Ali H Bahkali, Ayaz Mukarram Shaikh, Béla Kovács, Mohd Sajid Khan, Asad Syed
Transition metal oxide NPs have delivered wide applications in various fields. Therefore, in this study, a novel fungus, Alternaria sp. (NCBI Accession No: MT982648) was isolated and characterized from the vicinity of medicinal plants. Eventually, in this method extracted proteins from isolated fungus were utilized to synthesize highly biocompatible zinc nanoparticles (ZnO NPs). The various physical
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Antibacterial Properties of Ag-Cu Alloy Nanoparticles Against Multidrug-Resistant Pseudomonas aeruginosa Through Inhibition of Quorum Sensing Pathway and Virulence-Related Genes. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Mozhgan Pourjafari, Masood Ghane, Hami Kaboosi, Babak Sadeghi, Abolhasan Rezaei
Objective: To evaluate the application of Ag-Cu NPs as quorum sensing (QS) inhibitors and attenuate virulence expression to overcome the global crisis of multidrug-resistant (MDR) P. aeruginosa. Methods: Ag-Cu NPs were synthesized by co-reduction of silver-nitrate and copper-nitrate (Ag:Cu = 1:1 0.75 μM). In this cross-sectional study, a total of eighty clinical strains of P. aeruginosa were collected
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The Application of Sensitive Nano-Confined Nanoparticle System Using siRNA Targeting Extracellular Signal-Regulated Kinase (ERK)/Mitogen-Activated Protein Kinase (MAPK) Pathway in Gastrointestinal Cancer. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Runda Wu, Shan Tong, Mohammad Saeed Kahrizi, Zheng Zhu, Xin Chen
In this study we tried to develop a Sensitive Nano-Confined Nanoparticles (S-NCN) system using siRNA against Programmed death-ligand 1 (PDL-1) and Polo Like Kinase 1 (Plk1) to treat gastrointestinal cancer. In this regard, we first synthesized the corresponding materials, prepared the S-NCN system, and verified its functionality. Subsequently, we demonstrated in vitro that S-NCN delivery of siPlk1
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Synchronous Signal Transmission Method of Minimally Invasive Renal Failure Surgery Based on Nano Molecular Image Probe. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Fu Zheng, Dan Tian, Dan Chen, Nana Yao, Hongbo Chen, Xiaohui Hu, Yong Lan, Su Chen
The synchronous signal transmission can promote the successful completion of minimally invasive renal failure surgery, so the synchronous signal transmission method of minimally invasive renal failure surgery based on nano molecular image probe is studied. The nanoprobe is constructed by loading different signal molecules, photosensitizers, acoustic sensitizers and thermosensitives through the method
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Two New 3D Supramolecular Complexes: Photocatalytic Properties and Treatment Activity for Gastric Cancer. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Jiangkun Lu, Wei Yu, Guoguo Ji, Ming Wu, Jinhong Geng, Jinhui Qi, Jianming Gong
Two new coordination polymers, [Cu₂(5-MeO-Hip)₄(py)₄]n (1) and [Co(5-EtO-ip)(4,4'-bipy)]n·n(MeOH) (2) (5-MeO-H₂ip is 5-methoxyisophthalic acid, 5-EtO-H₂ip is 5-ethoxyisophthalic acid, py is pyridine, and 4,4'-bipy is 4,4'-bipyridine), were created via solvothermal self-assembly. The thermal steadiness and photocatalytic functions of 1 and 2 were detected, and their application values in gastric cancer
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Inhibiting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants: Targeting the Spike and Envelope Proteins Using Nanomaterial Like Peptides. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Alaa F Nahhas, Alrayan F Nahhas, Abdulrahman A Alshaikh, Thomas J Webster
Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused significant death, economic crisis, and the world to almost completely shut down. This present study focused on targeting the novel SARS-CoV-2 envelope protein, which has not been frequently mutating, and the S protein with a much larger peptide capable of inhibiting virus-mammalian cell
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Enhanced Glioblastoma Selectivity of Harmine via the Albumin Carrier. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Shi-Hui Liu, Qing-Zhen Wang, Tao Liu, Ru Bai, Man-Man Ma, Qiao-Lin Liu, Hui-Ge Zhou, Jing Liu, Mei Wang
Glioblastoma, the most common tumor in the brain, has witnessed very little clinical progress over the last decades. Exploring and discovering new therapeutic strategies for glioblastoma has become a critical problem. Harmine (HM), belonging to the beta-carboline alkaloid, is a natural product and isolated from the seeds of Peganum harmala L., which own notable antitumor activity in vitro. However
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A Time-Course Evaluation of DNA Damage and Neurotoxicity Induced by PEGylated Graphene Oxide Nanoparticle in Swiss Albino Mice. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Nojood Altwaijry, Qura Tul Ain, Hissah Alnuwaysir, Abir Alamro, Amani Alghamdi, Samina Hyder Haq
PEGylated graphene oxide nanoparticle (PEG-nGO) has been commonly used as a carrier for therapeutic drugs and vaccines, because of its unique properties, such as high solubility, more stability and increased biocompatibility in physiological solutions. This study aimed to examine the DNA damage and neurotoxicity in young mice after up to 4 h of the treatment with PEG-nGO. A single dose (5 mg/kg) of
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Colorimetric Aptasensor Based on Fe₃O₄-Cu2+ Nanozyme with Intrinsic Peroxidase-Like Activity in the Detection of Breast Cancer Exosomes. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Jian Long, Fang Wang, Guohua Zha, Kaijun Che, Jingfang Luo, Zhiqiang Deng
Because breast cancer cells such as MCF-7, exhibit vital and developmental signs by exosome secretion, diagnosing them in the blood can provide a good index of the presence of breast cancer. However, accurate and inexpensive detection of exosomes in clinical practice faces challenges. Therefore, in the presents study, an aptasensor based on CD63 aptameriron oxide-copper ion nanozymes (Fe₃O₄-Cu2+-NZs)
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A New Gold Nanoparticles and Paclitaxel Co-Delivery System for Enhanced Anti-Cancer Effect Through Chemo-Photothermal Combination. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Honglei Zhan, Wenjing Song, Mingyang Gu, He Zhao, Yujia Liu, Bingnan Liu, Jihui Wang
Limited chemotherapeutic efficiency, drug resistance and side effect are primary obstacles for cancer treatment. The development of co-delivery system with synergistic treatment modes should be a promising strategy. Here, we fabricated a multi-functionalized nanocarrier with a combination of chemotherapeutic agent and gold nanoparticles (AuNPs), which could integrate chemo-photothermal therapy and
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Resveratrol Nanoparticles Suppresses Migration and Invasion of Renal Cell Carcinoma Cells by Inhibiting Matrix Metalloproteinase 2 Expression and Extracellular Signal-Regulated Kinase Pathway. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Xing-Wang Zhu, Feng-Ming Dong, Jia Liu, Ming-Shan Li
The aim of this study was to examine the impact of Resveratrol nanoparticles on migration/invasion capacity of renal cell carcinoma (RCC) cells and its mechanism. Human RCC cells were exposed to dimethyl sulfoxide or gradient concentrations of Resveratrol nanoparticles respectively, and U0126 were also added in some experiments. We examined renal cell viability by MTT assay, and wound healing test
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Novel Au-Se Nanoprobes for Specific Thrombin Detection in Diagnosis of Lung Cancer. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Koujun Zhu, Rongguo Lu, Weifeng Qu, Jiaqi Gu, Hu Xiang, Weimin Zhang, Bin Ni
Thrombin is associated with malignant tumors and promotes tumor development, metastasis, and angiogenesis, therefore its identification especially in lung cancer cells is crucial. Because the interference of in vivo biothiols caused false positive findings with prior gold fluorescent nanoprobes, in this manuscript, an Au-selenol(Se) nanoprobe (5-FAM-peptide-Se-AuNPs) that could specifically detect
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Targeted Therapy of Lung Adenocarcinoma by the Nanoplatform Based on Milk Exosomes Loaded with Paclitaxel. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Junge Chen, Fengqiang Cao, Yang Cao, Shujin Wei, Xiurui Zhu, Wanli Xing
Lung cancer is the most common cancer throughout the world. Currently, most lung cancer therapies are still limited by serious side effects caused. This paper reports a biocompatible drug delivery system that utilizes milk-derived exosomes to deliver paclitaxel to treat lung adenocarcinoma. First, milk-derived exosomes were modified with integrin αVβ₃, αVβ5-binding peptide iRGD so that they could successfully
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Ferromagnetic Vortex Iron Oxide Nanorings Modified with Integrin β1 Antibody for Targeted MRI Tracking of Human Mesenchymal Stem Cells. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Yujie Wang, Yinjuan Lv, Yuxuan Li, Hongying Bao, Chenggong Yu, Xiaodi Li, Jiaqiang Xu, Jie Huang, Zhijun Zhang
Mesenchymal stem cells (MSCs) have demonstrated great potential for tissue engineering and regenerative medicine applications. Noninvasive and real-term tracking of transplanted MSCs in vivo is crucial for studying the distribution and migration of MSCs, and their role in tissue injury repair. This study reports on the use of ferrimagnetic vortex iron oxide (FVIO) nanorings modified with anti-human
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Targeting the Conserved Sequence of the Substrate for the Proteinase of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2) Using Nano-Networks: Efficacy, Stability, and No Cytotoxicity. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Alaa F Nahhas, Thomas J Webster
Herein, we designed a nano peptide that contains three important motifs for targeting the chemotrypsin-like cysteine protease (3CLpro) which is the enzyme responsible for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) replication. The novel nano peptide contains the Nap Phe-Phe motif that is responsible for peptide self-assembly, an octapeptide (Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe) motif
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Protective Effect of Iron Oxide Nanoparticles on Periodontal Injury in Rats by Inhibiting Collagenase-1 and Alkaline Phosphatase Expression. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Yirui Wang, Zhixiong Liang, Liang Chen, Guosheng Yang, Jing Xu, Chunmei Deng, Chun Wang, Changjiang Lei
This study intends to assess whether iron oxide nanoparticles affect periodontal injury and collagenase-1 (COL-1), and alkaline phosphatase (ALP) in rats. In this study, the ALP activity and Col-1 concentration in rats with periodontal injury were determined.We detected the periodontal histopathological changes and expression of periodontal pocket depth (PD) and attachment loss (AL) by Hematoxylin
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Cyclovirobuxine D Brain-Targeted Liposomes Improve Cerebral Ischemia-Reperfusion Injury via Anti-Oxidant Stress and Activating Autophagy. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Fang Yang, Lingzhi Ren, Tuo Liu, Xiangyi Lu, Chang Liu, Yang Yu, Zhilian Chen, Yongling Long
One of the main issues faced by nervous system diseases is that drugs are difficult to enter the brain. The previous study suggested that Cyclovirobuxine D (CVBD) encapsulated in Angiopep-conjugated Polysorbate 80-Coated Liposomes showed a better brain targeting by intranasal administration. Therefore, this study concentrated on the protection and mechanism of CVBD brain-targeted liposomes in treating
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Carrier-Free Nanomedicine for Cancer Immunotherapy. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Yu Fu, Xufei Bian, Pingrong Li, Yulan Huang, Chong Li
With the rapid development of nanotechnology, carrier-based nano-drug delivery systems (DDSs) have been widely studied due to their advantages in optimizing pharmacokinetic and distribution profiles. However, despite those merits, some carrier-related limitations, such as low drug-loading capacity, systematic toxicity and unclear metabolism, usually prevent their further clinical transformation. Carrier-free
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Research on Mechanism of Nanometric Bone Pulp Activated with Double Gene as Bone Morphogenetic Protein 1 and Vascular Endothelial Growth Factor for Improving the Strength of Centrum in Osteoporosis. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Cheng-Liang Zhang, Da-Jiang Song, Li-Dong Zhang, Lei Liu, Bao-Lin Zhu
The aim of this study was assessing the mechanism of nanometric bone pulp activated with double gene as bone morphogenetic protein 1 (BMP-1) and vascular endothelial growth factor (VEGF) in improving the strength of centrum in osteoporosis (OP). The model of nanometric bone pulp activated with BMP-1 and VEGF double gene was established and validated. Under maximum condition of load and collapsed fragments
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Effect of Porous Zirconia Coating on Human Gingival Fibroblasts and Its Mechanism. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-7-21 Jiangqi Hu, Yue Qie, Yu Luo, Qingsong Jiang
Gingival fibroblasts play an important role in the constitution of soft tissue attachment. This study aims to investigate whether porous zirconia coating has a positive effect on promoting human gingival fibroblast attachment. The porous zirconia coating was loaded on zirconia surface by the dip coating method, surface morphology and composition were confirmed by scanning electron microscope and energy
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A Nucleus-Targeted Nanosystem Integrated with Photodynamic Therapy and Chemotherapy. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Jing Xin, Sijia Wang, Jing Wang, Lei Fu, Zhenxi Zhang, Cuiping Yao
Minimally invasive photodynamic therapy, destroying lesions with a light-activated photosensitizer, has been increasingly performed since it is highly efficiency, safe, synergistically compatible, repeatable, and minimally-invasive, with few adverse reactions. However, the most present photosensitizer or nanodrug delivery system containing a photosensitizer can target tumor cells but rarely cell nuclei
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Toxicity of Nanoparticles of AgO, La₂O₃, CuO, AgO-Fe₃O₄, Ag-Graphene, and GO-Cu-AgO to the Fungus Moniliella wahieum Y12T Isolated from Degraded Biodiesel and the Bacterium Escherichia coli. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Lin Zhang, Qing X Li, Xiaotong Li, Brandon Yoza, Lingyan Zhou
Moniliella wahieum Y12T (M. wahieum Y12T), a fungal isolated from biodiesel caused serious biodiesel contamination and resulting in biofouling and corrosion, especially during storage. Nanoparticles (NPs) composed of silver, copper, iron, and graphene or their binary mixtures were examined as environmental inhibitors against the fungus Moniliella wahieum Y12T, a biodiesel contaminant. Exposure of M
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Multifunctional Electrospun Textiles for Wound Healing. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Guopu Chen, Jie Hu, Zhiwu Hong, Gefei Wang, Zhiming Wang, Canwen Chen, Jinjian Huang, Xiuwen Wu, Jianan Ren
The novel multifunctional electrospun textiles were fabricated by incorporating sheet-like kaolinite and silver nanoparticles (AgNps) into a polyurethane (PU) textile by using electrostatic spinning to promote wound-healing process. Threedimensional network of PU electrospun textiles offered an appropriate framework for loading kaolinite nanosheets and AgNps. Moreover, the kaolinite nanosheets healed
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Double Nutri (Liposomal Encapsulation) Enhances Bioavailability of Vitamin C and Extends Its Half-Life in Plasma. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Chiung-Jung Wen, Chi-Fu Chiang, Chung-Sheng Lee, Yung-Hsiang Lin, Jaw-Shiun Tsai
Vitamin C is an important antioxidant in the human body that plays a role in many body functions. Liposomal encapsulation is a technology commonly used in food processing and medicine. This study determines whether Double Nutri (liposomal encapsulation) increases the absorption rate for vitamin C supplementation. Subjects enrolled in this study took vitamin C without liposome; then, 14 d washout was
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Mitochondria-Targeted Degradable Nanocomposite Combined with Laser and Ultrasound for Synergistic Tumor Therapies. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Shuang Zhu, De-Qiang Wang, Xue-Hua Sun, Xin-Yu Li, Hui-Fang Xiao, Wan-Ru Sun, Xing-Tao Wang, You-Jie Li, Ping-Yu Wang, Shu-Yang Xie, Ran-Ran Wang
Although the development of safe and efficient cancer therapeutic agents is essential, this process remains challenging. In this study, a mitochondria-targeted degradable nanoplatform (PDA-MnO₂-IR780) for synergistic photothermal, photodynamic, and sonodynamic tumor treatment was investigated. PDA-MnO₂-IR780 exhibits superior photothermal properties owing to the integration of polydopamine, MnO₂, and
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Serum Extracellular Nano-Vesicles miR-153-3p to Identify Micronodular Lung Cancer from Sub-Centimeter Lung Nodules. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Yuxia Deng, Rongyu Xue, Nishant Patel, Wenwen Xu, Haijun Zhang
Identification of malignancy from sub-centimeter lung nodules (LNs, <1 cm) is core for prevention and treatment of primary phases of lung cancer (LC). The study's purpose was to predict micro-nodular lung cancer (mnLC), such as adenocarcinoma in situ (AIS), micro-invasive adenocarcinoma (MIA), and invasive adenocarcinoma stage 1 (IA1) based on serum extracellular nano-vesicles (sEVs) miR-153-3p. sEVs-miR-153-3p
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Construction of a New Dual-Responsive Nano-Drug Delivery System for Matrix Metalloproteinases and Adenosine Triphosphate in Ovarian Cancer Using Nanomicelles. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Guocheng Li, Wenwen Xu, Yong Shi, Mengzhu Chen, Danhong Peng
In this manuscript we constructed a dual-responsive nano-drug delivery system for matrix metalloproteinases and ATP in ovarian cancer microenvironment. The nanomicelle PCL-DNA/DOX-Peptide-PEG was prepared by intercalating doxorubicin hydrochloride between C and G base pairs of DNA double helix structure. Another ATP-responsive nanomicelle PCL-DNA/DOX-PEG was prepared. Then we analyzed the characterization
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The Molecular Mechanism of Long Non-Coding RNA (LncRNA) Regulation of Notch Signaling in Glucose-Induced Apoptosis of Human Retinal Vascular Endothelial Cell. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Yang Zhao, Shouqing Li, Bihua Xie
Diabetes, a global health concern, affects the health of more than 500 million adults. The absence of Notch protein can cause an imbalance in the retinal vascular environment and cause retinal vascular disease. Long noncoding RNA (lncRNA) is known to be involved in the regulation of many signaling pathways. We hope to understand the specific mechanism of apoptosis in retinal vascular endothelial cells
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Development of a Quantum Dot-Based Fluorescence-Linked Immunosorbent Assay for Puerarin. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Bing-Qian Jiang, Guo-Liang Cheng, Yue Zhang, Hui Kong, Jie Zhao, Yifan Zhang, Tong Wu, Yan Zhao, Hui-Hua Qu
In this study, a rapid and highly sensitive fluorescence-linked immunosorbent assay for puerarin determination was developed by the conjugation of quantum dots with an antibody against puerarin. The linear range and detection limit of the fluorescence-linked immunosorbent assay were validated. The detection curve (y = -1041ln(x)+5366, R² = 0.999) was linear in the range of 7.8-125 ng/mL. The 50% inhibitory
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3D-Printed Bionic Titanium Alloy Artificial Lamina Prevents Epidural Adhesion and Restores the Stability After Laminectomy in Pigs. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Jianwen Li, Zhongjia He, Xianyin Liu, Songbo Li, Yuchao Yin, Guanjun Fang, Yaoxin Chen, Guangxing Pang, Jianfeng Lu, Zhiwei Liu, Guobiao Ye
Laminectomy can cause the dura mater to adhere to the surrounding scar tissue, leading to soft spinal stenosis after surgery. Although artificial laminae are considered ideal substitutes, they present challenges such as insecure fixation and insufficient bionics. In this study, we fabricated a bionic titanium alloy artificial lamina using three-dimensional (3D)-printing technology and evaluated its
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Two-Photon Nanoprobe for NIR-II Imaging of Tumour and Biosafety Evaluation. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Yiqian Zha, Xinyuan Cui, Yanlei Liu, Shanshan Fan, Yi Lu, Shengsheng Cui, Daxiang Cui
How to develop near-infrared second window (NIR-II, 1000-1700 nm) fluorescent nanoprobes with a uniform size, strong fluorescence signal and good biosafety owns great clinical requirement. Herein we reported that a two photon fluorescent nanoprobe was developed via encapsulating NIR-II-fluorescent molecules into DSPE-PEG, which was effectively endocytosized by cancer cells, and achieved strong NIR-II
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Engineering PD-L1 Cellular Nanovesicles Encapsulating Epidermal Growth Factor for Deep Second-Degree Scald Treatment. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Xiao-Feng Zhu, Dan-Dan Su, Xin-Hui Tian, Cheng Yang, Wei-Xian Zhang, Xin-Rui Yang, Man-Qi Zhang, Li-Fang Xi, Lan Wei, Hong-Bo Chen, Fang Cheng, Yu-Xin Pang
Scars are common and intractable consequences after scalded wound healing, while monotherapy of epidermal growth factors does not solve this problem. Maintaining the stability of epidermal growth factors and promoting scarless healing of wounds is paramount. In this study, engineering cellular nanovesicles overexpressing PD-L1 proteins, biomimetic nanocarriers with immunosuppressive efficacy, were
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Study on the Expression of β-1,3-N-acetylglucosaminyltransferase 3 in Gastric Cancer and the Mechanism Promoting Gastric Cancer Progression Based on the Extraction Method of Nanomagnetic Beads. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Huijun Zhou, Jinfeng Zhao, Xiaolin Yang, Jie Liu, Wei Huang
The oncogenic role of β-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3) in several cancers is well documented. However, the expression, function, and mechanism of B3GNT3 in gastric cancer (GC) remain to be investigated. Here, we extracted RNA using the nanomagnetic bead method and investigated B3GNT3 expression in GC and its mechanism for promoting malignant progression of GC using bioinformatics, quantitative
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Poly d,l-(lactic-co-glycolic) Acid PEGylated Isoliquiritigenin Alleviates Traumatic Brain Injury by Reversing Cyclooxygenase 2 Level. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Zhengyang Li, Chao Xu, Yan Wang
As a severe neurological disease of trauma, traumatic brain injury (TBI) leads to other disorders, such as depression, dementia and epilepsy. This study investigated whether poly d,l-(lactic-co-glycolic) acid (PLGA) PEGylated isoliquiritigenin could alleviate TBI. One hundred and eighty-three patients with clinical brain trauma were divided into two groups with or without intracranial injury in magnetic
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Co-Encapsulation of Violacein and Iron Oxide in Poly(lactic acid) Nanoparticles for Simultaneous Antibacterial and Anticancer Applications. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Maria Kanelli, Bahram Saleh, Thomas J Webster, Stamatina Vouyiouka, Evangelos Topakas
To date, the possibility of drug-resistant bacterial infections in hospitals and intensive care units comprises a significant concern especially for immunocompromised cancer patients. In the current study, violacein and superparamagnetic iron oxide nanoparticles were co-encapsulated in polylactic acid nanoparticles (vio-Fe₃O₄-PLA) and tested for their antimicrobial and anticancer activity. The loaded
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Treg Cell Evaluation in Patients with Acquired Immune Deficiency Syndrome with Poor Immune Reconstitution and Human Immunodeficiency Virus-Infected Treg Cell Prevention by Polymeric Nanoparticle Drug Delivery System. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Linsong Liu, Gang Yuan, Fuyan Sun, Jinchuan Shi, Heling Chen, Yaoren Hu
To better deliver antiretroviral drugs for treating patients with acquired immune deficiency syndrome (AIDS) with poor immune reconstitution, a novel nanopole capsule was designed in this study. Forty-eight patients with AIDS with poor immune reconstitution were chosen as subjects to test their immune state. CD4+ T and Regulatory T cells (Treg) infected with HIV were cultured to test polyethyleneimine
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Photothermolysis Mediated by Gold Nanorods Conjugated with Epidermal Growth Factor Receptor (EGFR) Monoclonal Antibody Induces Apoptosis via the Mitochondrial Apoptosis Pathway in Laryngeal Squamous Cell Cancer. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Shi-Wen Zhang, Hao Wang, You-Yu Qiu, Ren-Chao Huang, Zi-Chen Dong, Lu Zhang, Liu-Fang Zhao, Hong-Yang Xu, Wei-Di Sun
Gold nanorods (AuNRs) have unique optical properties and biological affinity and can be used to treat tumors when conjugated with other protein molecules. Our previous studies have shown that EGFR monoclonal antibody (EGFRmAb)-modified AuNRs exert strong antitumor activity in vitro by inducing apoptosis. In this study, we tested the effects of EGFRmAb-modified AuNRs on laryngeal squamous cell cancer
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Effect of Hydroaloholic Extract of Rotula Aquatica Lour on Gentamicin-Induced Nephrotoxicity in Wistar Albino Rats: An In Vitro and In Vivo Approach. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Siju Ellickal Narayanan, Mohamed A Abdelgawad, Yusuf S Althobaiti, Mohammed M Ghoneim, Rajalakshmi Ganesan Rajamma, Nikhila Sekhar, Della G T Parambi, Lekshmi R Nath, S K Kanthlal, Bijo Mathew
One-third of the world population suffer from kidney complications such as acute and chronic renal failure, renal calculi, kidney stones, Fanconi's syndrome and urethritis which doesn't have a proper effective treatment regimen. The current study explores the nephroprotective effect of herbal drug Rotula Aquatica by both In Vitro and In Vivo methods. MTT assay was applied In Vitro to evaluate the nephroprotective
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Accelerated Neutral Atom Beam (ANAB) Modified Poly-Ether-Ether-Ketone for Increasing In Vitro Bone Cell Functions and Reducing Bacteria Colonization Without Drugs or Antibiotics. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Thomas J Webster, Jeffrey R Shallenberger, Elazer R Edelman, Joseph Khoury
Poly-ether-ether-ketone (PEEK) has become the spinal implant material of choice due to its radiolucency, low elastic modulus, manufacturability, and mechanical durability. However, studies have highlighted less that optimal cytocompatibility properties of conventional PEEK leading to decreased bone growth and/or extensive bacteria infection. In order to improve the surface properties of PEEK for orthopedic
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Circulating Abnormal Extracellular Vesicles: Their Mechanism for Crossing Blood-Brain Barrier, Effects on Central Nervous System and Detection Methods. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Boyue Fan, Jiaqi Gu, Jie Wu, Yifan Sun, Rongrong Huang, Han Shen, Xu Zhang, Zhiyang Li
Central nervous system (CNS) diseases are difficult to treat and harmful. Many CNS diseases are secondary to peripheral diseases, such as tumor brain metastases (BMS), viral infections and inflammation of the brain, and their pathogenic factors travel through the circulatory system to the brain, eventually leading to lesions. Extracellular vesicles (EVs) play an important role in this process. Recent
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Nanoparticles Loaded with GSK1059615 Combined with Sorafenib Inhibited Programmed Cell Death 1 Ligand 1 Expression by Negatively Regulating the PI3K/Akt/NF-κB Pathway, Thereby Reversing the Drug Resistance of Hepatocellular Carcinoma to Sorafenib. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Shuping Zhou, Yongfang Ma, Ruyue Xu, Xiaolong Tang
Activation of the cellular signaling pathways can induce sorafenib-resistant hepatocellular carcinoma (HCCR). In this work, the PI3K/mTOR inhibitor GSK1059615 inhibited the proliferation and invasion of HCCR cells. PLGA-PEG-mal diblock copolymer was used to load GSK1059615 and sorafenib, and the vector was further modified with GPC3 antibody (hGC33) to obtain hGC33-modified GSK1059615 and sorafenib-loaded
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Nanocarrier-Based Tumor-Targeting Drug Delivery Systems for Hepatocellular Carcinoma Treatments: Enhanced Therapeutic Efficacy and Reduced Drug Toxicity. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Tian Tian, Jian Ruan, Jia Zhang, Chun-Xia Zhao, Dong Chen, Jianzhen Shan
Hepatocellular carcinoma (HCC), due to the lack of efficient diagnostic methods and short of available treatments, becomes the third main cause of cancer deaths. Novel treatments for HCCs are thus in great need. The fast-growing area of drug delivery provides intriguing possibility to design nanocarriers with unique properties. The nanocarriers performanced as drug deliver vehicles enable the design
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The Treatment of Human Colon Xenografts Tumor in Mice with Platinum Nanosphere-5-Fluorouracil-Bovine Albumin. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Hui Li, Yi Sun, Li-Li Gao, Yong-Feng Tang, Zheng Zhao
Because 5-fluorouracil (FLU) has side effects in cancer treatment, the use of FLU in therapeutic activities is limited. To overcome this challenge, the use of nano-platforms for its targeting is f great interest in biomedical fields. For this purpose, to reduce the FLU toxicity and improve the its efficacy, platinum nanospheres (PtNS) with anti-cancer properties were used. After producing PtNS by hydrothermal
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X-Linked Inhibitor of Apoptosis Protein (XIAP)-Loaded Magnetic Mesoporous Silica Nanoparticles Incorporated with miR-233 to Improve Radio Sensitization of Cervical Cancer Cells and Promote Apoptosis. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Wen Li, Fang Li, Yang Zhang, Hongtao Ren, Xing Bao, Zhongwei Wang, Yali Wang
This study investigated the impact of magnetic mesoporous silica nanoparticles (MMSN)-encapsulated X-linked inhibitor of apoptosis protein (XIAP) and miR-233 on tumor microenvironment in cervical cancer, to provide targeted treatment and strategy, to improve radio sensitization of cancer cells. Cervical cancer cells were treated with normal saline (control group), XIAP-loaded metallic mesoporous silica
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Dual pH and Temperature-Sensitive Nanogels Loaded with Eugenol for Regulating Central Nervous System. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Yan Li, Jing-Wen Wang, Qiu-Shi Dong, Bao-Chang Zhao, Ji-Mei Zhang, Yan-Ling Li, Zhi-Guo Lu, Xin Zhang
Fragrances have many biological activities such as anti-anxiety, anti-depression, and improving cognitive memory. However, most fragrances are so volatile that the useful lifespan of the fragrances is very short and excessive fragrance concentration makes us uncomfortable. In this study, dual pH and temperature-sensitive nanogels named EG@CPMONGs were prepared to encapsulate eugenol. This nano-fragrance
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Coating Silica Layer on Fe₃O₄ Magnetic Nanoparticles and Application in Extracting High Quality Nucleic Acids from Blood Sample. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Zeeshan Ali, Jun Zou, Xiaolong Liu, Yongkai Bai, Mubashir Hussain, Lijun Zhang, Zhu Chen, Hui Chen, Song Li, Yan Deng, Yuanying Zhang, Yongjun Tang
The given research revealed that the size of Fe₃O₄ magnetic nanoparticles (MNPs) could be controlled by varying the pre-mixing conditions in the solvothermal method. Scanning electron microscopy (SEM) showed that the size of the MNPs gradually increased with increasing the initial temperature at which reaction components were mixed while the reaction component's mixing time was kept constant. The smallest
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Enhanced Antibacterial and Osteogenic Properties of Graphene Oxide Loaded with Berberine on Biomedical Titanium. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Xia-Ying Han, Tong Meng, Jian-Xin Ye, Hua-Bin Yin, Dian-Wen Song
Internal implants are widely used in most orthopedic surgeries, of which titanium and its alloys are most widely used owing to the excellent corrosiveness resistance, low elastic modulus and good biocompatibility. However, implant failure still occurs for that titanium and its alloys themselves do not own antibacterial and osteogenic properties. In this work, we successfully fabricated berberine-loaded
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Recent Advances of Human Leukocyte Antigen (HLA) Typing Technology Based on High-Throughput Sequencing. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Jin Yang, Hongna Liu, Wenjing Pan, Mengru Song, Yutong Lu, Franklin Wang-Ngai Chow, Polly Hang-Mei Leung, Yan Deng, Masahi Hori, Nongyue He, Song Li
The major histocompatibility complex (MHC) in humans is a genetic region consisting of cell surface proteins located on the short arm of chromosome 6. This is also known as the human leukocyte antigen (HLA) region. The HLA region consists of genes that exhibit complex genetic polymorphisms, and are extensively involved in immune responses. Each individual has a unique set of HLAs. Donor-recipient HLA
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Targeting Pulmonary Artery Infusion of Nuclear-Targeted Plasmid-Based Short Hairpin RNA (ShRNA) to Hypoxia Inducible Factor-1α3 (pshHIF-1α3) Nano-Microspheres for Treatment of Implanted Lung Cancer in Rats. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Rui Zhao, Shan Gao, Haiqi He, Jia Zhang, Guangjian Zhang, Xiaopeng Wen
The pshHIF-1α3 stealth nanospheres have been studied if they have the function of arterial targeted drug delivery to provide a new arterial targeted drug delivery method for interventional therapy of lung cancer. The study is also aimed at exploring therapeutic effect of the checked drug delivery on lung cancer. The tested groups were designed as follows: Group I: blank control group (pulmonary artery
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Accelerated Neutral Atom Beam (ANAB) Modified Polypropylene for Reducing Bacteria Colonization Without Antibiotics. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-6-19 Luting Liu, Joseph Khoury, Thomas J Webster
For this first time, this study utilized Accelerated Neutral Atom Beam (ANAB) technology to modify polypropylene to inhibit bacteria colonization in vitro after 24 hours without the use of drugs or antibiotics. Specifically, ANAB was designed and used to increase the surface energy of polypropylene to be closer to that of two critical proteins (mucin and casein) contained in bodily fluids that if adsorbed
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Effectiveness of Nano Bioactive Glass Fiber Loaded with Platelet-Rich Plasma on Thermal Wound Healing Process in Rats. J. Biomed. Nanotechnol. (IF 2.9) Pub Date : 2022-4-30 Xuanru Zhu, Aida Kazemi, Yunqing Dong, Qiao Pan, Panshi Jin, Biao Cheng, Yangog Yang
In this study we evaluated the impact of topical application of bioactive glass fibers loaded PRP on a deep seconddegree thermal wound and its healing process sub-streaming molecular pathway of re-epithelialization. Wistar rats were randomly divided into four groups: normal control group, model group (deep second-degree thermal wound), PRP group, and PRP+nanobioactive glass fiber group. After treatment