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Optimization, fabrication, and characterization of four electrode-based sensors for blood impedance measurement Biomed. Microdevices (IF 2.176) Pub Date : 2021-01-15 Rangadhar Pradhan, Sanjana Afrin Raisa, Pramod Kumar, Ashish Kalkal, Narendra Kumar, Gopinath Packirisamy, Sanjeev Manhas
In this work, an optimized, non-invasive four electrode-based impedimetric sensors have been designed, fabricated, and characterized for measuring the impedance of a biological cell. The impedimetric sensors having four mono-polar electrodes were fabricated utilizing the photolithography technique with gold as the electrode material. Furthermore, the impedance of the electrolyte/electrode interface
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An Oral-mucosa-on-a-chip sensitively evaluates cell responses to dental monomers Biomed. Microdevices (IF 2.176) Pub Date : 2021-01-11 Khanh L. Ly, Seyed Ali Rooholghodos, Christopher Rahimi, Benjamin Rahimi, Diane R. Bienek, Gili Kaufman, Christopher B. Raub, Xiaolong Luo
Knowledge of human gingival cell responses to dental monomers is critical for the development of new dental materials. Testing standards have been developed to provide guidelines to evaluate biological functionality of dental materials and devices. However, one shortcoming of the traditional testing platforms is that they do not recapitulate the multi-layered configuration of gingiva, and thus cannot
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Biomimetic soft micro-swimmers: from actuation mechanisms to applications Biomed. Microdevices (IF 2.176) Pub Date : 2021-01-09 Shihan Fu, Fanan Wei, Chao Yin, Ligang Yao, Yaxiong Wang
Underwater robot designs inspired by the behavior and morphological characteristics of aquatic animals can provide reinforced mobility and energy efficiency. In the past two decades, the emerging materials science and integrated circuit technology have been combined and applied to various types of bionic soft underwater miniaturized robots by researchers around the world. Further, the potential applications
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Therapeutic approach for global myocardial injury using bone marrow-derived mesenchymal stem cells by cardiac support device in rats Biomed. Microdevices (IF 2.176) Pub Date : 2021-01-08 Ziwei Liu, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Reyaj Mikrani, Cuican Li, Muhammad Saeed, Qin Zhang, Muhammad Asim Farooq, Hafiz Muhammad Zubair, Zhou Xiaohui
Bone marrow-derived mesenchymal stem cells (BMSCs) have been considered a promising therapeutic approach to cardiovascular disease. This study intends to compare the effect of BMSCs through a standard active cardiac support device (ASD) and intravenous injection on global myocardial injury induced by isoproterenol. BMSCs were cultured in vitro, and the transplanted cells were labeled with a fluorescent
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Effective clearance of uremic toxins using functionalised silicon Nanoporous membranes Biomed. Microdevices (IF 2.176) Pub Date : 2021-01-08 Ananya Ghosh, Fidal Vallam Thodi, Sudeshna Sengupta, Sivasundari Kannan, Lalitha Krishnan, Enakshi Bhattacharya
In-house fabricated silicon nanoporous membranes (SNMs), functionalized for efficient clearance of uremic toxins, can lead to compact and portable dialysis systems. Efficacy of 15 nm thick SNMs, with average pore diameter of 8 nm, was tested for dialysis of two uremic toxins - urea and creatinine using custom made teflon apparatus of 2, 10 and 30 ml. The apparatus consisted of two reservoirs, with
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A novel method for processing adipose-derived stromal stem cells using a closed cell washing concentration device with a hollow fiber membrane module Biomed. Microdevices (IF 2.176) Pub Date : 2021-01-06 Shinji Hayashi, Rieko Yagi, Shuhei Taniguchi, Masami Uji, Hidaka Urano, Shinya Yoshida, Hiroshi Sakurai
Cell-assisted lipotransfer (CAL) is an advanced lipoinjection method that uses autologous lipotransfer with addition of a stromal vascular fraction (SVF) containing adipose-derived stromal stem cells (ASCs). The CAL procedure of manual isolation of cells from fat requires cell processing to be performed in clean environment. To isolate cells from fat without the need for a cell processing center, such
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Cell viability and cytotoxicity of inkjet-printed flexible organic electrodes on parylene C Biomed. Microdevices (IF 2.176) Pub Date : 2021-01-02 Jaqueline S. Mandelli, Janice Koepp, Adel Hama, Sébastien Sanaur, Giles A. Rae, Carlos R. Rambo
This study reports on the fabrication of biocompatible organic devices by means of inkjet printing with a novel combination of materials. The devices were fabricated on Parylene C (PaC), a biocompatible and flexible polymer substrate. The contact tracks were inkjet-printed using a silver nanoparticle ink, while the active sites were inkjet-printed using a poly (3,4ethylenedioxythiophene)/polystyrene
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Modular design of paper based switches for autonomous lab-on paper micro devices Biomed. Microdevices (IF 2.176) Pub Date : 2020-11-27 Yashodeep Patil, Kevin Dotseth, Theodore Shapiro, Dhakshenan Pushparajan, Stephen Binderup, James R. Horn, Venumadhav Korampally
This paper presents a new approach towards the design of paper based autonomous microfluidic devices. Autonomy in the device operation is achieved through the incorporation of mechanically actuated microfluidic switches that are versatile in their design and may be configured to be simple time triggered ON or OFF switches or more complex switches that can be timed to be in multiple states (timed ON
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Emerging diagnostic tools for detection of COVID-19 and perspective Biomed. Microdevices (IF 2.176) Pub Date : 2020-11-24 Nidhi Verma, Dhaval Patel, Alok Pandya
The COVID-19 caused by a novel coronavirus, named Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has taken a great toll of life affecting lakhs of people around the globe. It was detected initially in Wuhan, China and has spread rapidly to more than 208 countries to date. A range of molecular and immunoassay-based techniques ranging from central laboratory testing to point-of-care tests
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Cell-encapsulated chitosan-collagen hydrogel hybrid nerve guidance conduit for peripheral nerve regeneration Biomed. Microdevices (IF 2.176) Pub Date : 2020-11-17 Shun Itai, Karin Suzuki, Yuta Kurashina, Hiroo Kimura, Tsuyoshi Amemiya, Kazuki Sato, Masaya Nakamura, Hiroaki Onoe
Nerve guidance conduits (NGCs) composed of biocompatible polymers have been attracting attention as an alternative for autograft surgery in peripheral nerve regeneration. However, the nerve tissues repaired by NGCs often tend to be inadequate and lead to functional failure because of the lack of cellular supports. This paper presents a chitosan-collagen hydrogel conduit containing cells to induce peripheral
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Design and testing of a novel gastrointestinal microrobot Biomed. Microdevices (IF 2.176) Pub Date : 2020-11-17 Wei Wang, Guozheng Yan, Ding Han, Yicun Meng, Pengxian Pu
In order to improve the reliability, safety and whole digestive applicability of the gastrointestinal microrobot (GMR), a novel inchworm-like GMR is proposed in this paper. The expanding mechanism of the robot adopts an overlapping expanding arm structure. This structure increases the variable diameter ratio (ratio of fully expanded diameter to fully folded diameter) of the robot to 3.3, making the
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Dynamic fabrication of microfluidic systems for particles separation based on optical projection lithography Biomed. Microdevices (IF 2.176) Pub Date : 2020-11-10 Lujing Sun, Wenguang Yang, Honghui Chu, Rendi Yang, Haibo Yu
Microfluidic systems are widely used for applications in biology, medicine and chemistry. Particles separation by microfluidics is a scientific subject that requires ongoing research efforts. In this article, we demonstrate a micropillar-based particles separator fabricated using digital micromirror device (DMD)-based optical projection lithography from the perspectives of theory, design, simulation
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Flexible and porous microneedles of PDMS for continuous glucose monitoring Biomed. Microdevices (IF 2.176) Pub Date : 2020-11-03 Kai Takeuchi, Nobuyuki Takama, Rie Kinoshita, Teru Okitsu, Beomjoon Kim
Microneedle (MN) is a key technology of the biomedical engineering field due to its capability of accessing the biological information in a minimally invasive manner. One of the huge demands for next-generation healthcare monitoring is continuous monitoring, especially of blood glucose concentration. For this, MN should be kept inserted into the human skin for a certain period of time, enduring stresses
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Love wave based portable sensing system for on-line detection of carcinoembryonic antigen in exhaled breath condensate Biomed. Microdevices (IF 2.176) Pub Date : 2020-10-26 Yingchang Zou, Yuan Zhou, Ying Chen, Xi Zhang, Chunxue Ran
Lung cancer is continuously the leading cause of cancer related death. Noninvasive exhaled breath condensate (EBC) detection using portable devices may pave a new avenue for monitoring conditions of the high-risk population of lung cancer, thereby increasing the 5-year survival rate. Here, a portable system is proposed for on-line detection of carcinoembryonic antigen (CEA) in EBC. This miniaturized
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Derma rollers in therapy: the transition from cosmetics to transdermal drug delivery Biomed. Microdevices (IF 2.176) Pub Date : 2020-10-26 Leonna Dsouza, Vivek M. Ghate, Shaila A. Lewis
Derma roller, a device rolled onto the skin to form micropores, is extensively used for cosmetic purposes. The pores thus created are utilized to either result in the induction of collagen production, leading to glowing and wrinkle-free skin or for permeating the applied formulations to the site of action within the skin. Recent studies have shown the benefits of using derma rollers for transdermal
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Eliminating air bubble in microfluidic systems utilizing integrated in-line sloped microstructures Biomed. Microdevices (IF 2.176) Pub Date : 2020-10-22 Can Huang, Jose A. Wippold, Dimitra Stratis-Cullum, Arum Han
In most microfluidic systems, formation and accumulation of air and other gas bubbles can be detrimental to their operation. Air bubbles in a microfluidic channel induce a pressure profile fluctuation and therefore disturb the stability of the system. Once an air bubble is generated, it is also extremely difficult to remove such bubbles from the microfluidic systems. In tissue and cell culture microfluidic
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High-throughput isolation of fetal nucleated red blood cells by multifunctional microsphere-assisted inertial microfluidics Biomed. Microdevices (IF 2.176) Pub Date : 2020-10-20 Zixiang Wang, Lin Cheng, Xiaoyun Wei, Bo Cai, Yue Sun, Yuanzhen Zhang, Lei Liao, Xing-Zhong Zhao
Being easy, safe and reliable, non-invasive prenatal diagnosis (NIPD) has been greatly pursued in recent years. Holding the complete genetic information of the fetus, fetal nucleated red blood cells (fNRBCs) are viewed as a suitable target for NIPD application. However, effective separating fNRBCs from maternal peripheral blood for clinic use still faces great challenges, given that fNRBCs are extremely
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Biologically synthesized of Au/Pt/ZnO nanoparticles using Arctium lappa extract and cytotoxic activity against leukemia Biomed. Microdevices (IF 2.176) Pub Date : 2020-10-10 Renata Dobrucka, Aleksandra Romaniuk-Drapała, Mariusz Kaczmarek
The main objective of this work was to assess the cytotoxic activity of Au/Pt/ZnO nanoparticles synthesized using Arctium lappa extract against leukemia. The Au/Pt/ZnO nanoparticles obtained as a result of biological synthesis were characterized by UV-Vis, Scanning (SEM) and Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and Atomic Force Microscopy (AFM). The
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Developing a versatile electrochemical platform with optimized electrode configuration through screen-printing technology toward glucose detection Biomed. Microdevices (IF 2.176) Pub Date : 2020-10-10 Xiao Li, Man Zhang, Yujie Hu, Jian Xu, Dongke Sun, Tao Hu, Zhonghua Ni
Rapid on-site detection of glucose has been attracting considerable attention nowadays. Screen-printed electrodes (SPEs) were assessed as ideal detection platforms due to their advantages such as, disposability, portability, ease of miniaturization, and mass production. The topology and shape of electrodes have a crucial impact on their electrical conductivity and electrochemical properties. In this
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A ten-minute, single step, label-free, sample-to-answer assay for qualitative detection of cytokines in serum at femtomolar levels Biomed. Microdevices (IF 2.176) Pub Date : 2020-10-10 Pengfei Xie, Naixin Song, Wen Shen, Mark Allen, Mehdi Javanmard
Label-free electronic affinity based immuno-sensing is an attractive candidate as a platform technology for analyzing biomarkers due to the ease of miniaturization and minimal use of reagents. Electronic based sensing approaches, however, have lagged behind their optical counterparts in terms of detection limit, selectivity, and reliability. Also, the matrix dependent nature of electronic sensing modalities
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Probe-antenna and multifunctional switch for biomedical neural implants Biomed. Microdevices (IF 2.176) Pub Date : 2020-10-09 Chi-Sing Yuen, Hsiao-Chin Chen
A probe-antenna and a multifunctional single-pole-four-throw switch are proposed for biomedical neural implants. The multifunctional switch is fabricated in TSMC 90-nm CMOS process and occupies the core area of 297 × 248 μm2. Operating in transmitter/receiver mode, the switch achieves the insertion loss of 4.5/4.8 dB, return loss of 16.7/15.4 dB, isolation of 19.2/20.3 dB and P1dB of 4/5 dBm at 60 GHz
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Resveratrol and Puerarin loaded polymeric nanoparticles to enhance the chemotherapeutic efficacy in spinal cord injury. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-22 Wei Chen,Zongqin Zhao,Shuchao Zhao,Lizhong Zhang,Qimin Song
Spinal cord injury includes inflammation and apoptosis of neurons, which is difficult to cure by systemic drug administration. Administration of natural active compounds (resveratrol and also Puerarin) by advance drug delivery technology improves the patient’s conditions. Oil-in-water emulsion method was utilized to prepare resveratrol as well as puerarin loaded PLGA nanoparticles. The nanoparticles
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Microfluidic-enabled self-organized tumor model for in vitro cytotoxicity assessment of doxorubicin. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-22 Yamin Yang,Sijia Liu,Chunxiao Chen,Haipeng Huang,Ling Tao,Zhiyu Qian,Weitao Li
The advent of microfluidic technologies has enabled a better recapitulation of in vitro tumor model with higher biological relevance over conventional monolayer assays. This work built upon a microfluidic system that supported the spontaneous aggregate formation of tumoral cells under flow-induced dynamic physical forces in a confined microchamber without additional matrix materials. Our findings indicated
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Naringenin loaded multifunctional nanoparticles to enhance the chemotherapeutic efficacy in hepatic fibrosis. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-21 Fan Yang,Shenghe Hu,Xun Sheng,Yu Liu
Naringenin is highly potent dietary phenolic compound (Flavonoids) found as a major bioactive in citrus fruits. The low solubility of Naringenin, decreases its availability at the site of action by hindering solubility and transportation across the biological membrane. Naringenin loaded nanoparticles enhance the solubility and drug availability at site of action. Naringenin solid lipid nanoparticles
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Self-assembled silver nanoparticle-DNA on a dielectrode microdevice for determination of gynecologic tumors. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-17 Zhao Li,Subash C B Gopinath,Thangavel Lakshmipriya,Periasamy Anbu,Veeradasan Perumal,Xizhen Wang
Nanoscale materials have been employed in the past 2 decades in applications such as biosensing, therapeutics and medical diagnostics due to their beneficial optoelectronic properties. In recent years, silver nanoparticles (AgNPs) have gained attention due to their higher plasmon excitation efficiency than gold nanoparticles, as proved by sharper and stronger plasmon resonance peaks. The current work
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Correction to: Project honeybee: Clinical applications for wearable biosensors. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-12 Leland Hartwell,Heather M Ross,Jeffrey T La Belle
The original version of this article unfortunately contained a mistake.
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Three-tissue microphysiological system for studying inflammatory responses in gut-liver Axis. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-11 Joong-Won Jeon,Nakwon Choi,Seung Hwan Lee,Jong Hwan Sung
The interaction between the gut and the liver, often known as the gut-liver axis, play crucial roles in modulating the body’s responses to the xenobiotics as well as progression of diseases. Dysfunction of the axis can cause metabolic disorders as well as obesity, diabetes, and fatty liver disease. During the progression of such diseases, inflammatory responses involving the immune system also play
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Carbon nanotube-collagen@hydroxyapatite composites with improved mechanical and biological properties fabricated by a multi in situ synthesis process. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-08 Haipeng Li,Xiwen Sun,Yuanjun Li,Hongshui Wang,Baoe Li,Chunyong Liang
A novel carbon nanotube-collagen@hydroxyapatite (CNT-Col@HA) composite with good mechanical and biological properties was fabricated successfully by a multi in situ synthesis process, which can be used to repair or replace the damaged bone tissues. The carbon nanotube (CNT)/hydroxyapatite (HA) composite powders were firstly synthesized by the in situ chemical vapor deposition method. After the acidification
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The use of micro-needle arrays to deliver cells for cellular therapies. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-05 Ying-Hou Chen,Dai-Chi Lin,Edward Chern,Yi-You Huang
Cell therapy is used to treat various diseases and to repair injuries. Cell delivery is a crucial process that delivers cells to target sites. Cells must be precisely delivered to a target site and the cells that are delivered must be localized to the target site to repair damaged tissue. For stem cell therapy, the most convenient method of cell delivery involves directly injecting cells into damaged
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Preparation of perfluorocarbon emulsions by premix membrane emulsification for Acoustic Droplet Vaporization (ADV) in biomedical applications. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-03 Romain Melich,Ali Zorgani,Frédéric Padilla,Catherine Charcosset
Perfluorocarbon (PFC) droplets are used in acoustic droplet vaporization (ADV), a phenomenon where droplets vaporize into gas microbubbles under exposure to ultrasound. The size and the size distribution of a phase change contrast agent is an important factor in determining the ADV threshold and the biodistribution. Thus, high throughout manufacturing of uniform-sized droplets, required to maintain
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Droplet size prediction in a microfluidic flow focusing device using an adaptive network based fuzzy inference system. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-02 Sina Mottaghi,Mostafa Nazari,S Mahsa Fattahi,Mohsen Nazari,Saeed Babamohammadi
Microfluidics has wide applications in different technologies such as biomedical engineering, chemistry engineering, and medicine. Generating droplets with desired size for special applications needs costly and time-consuming iterations due to the nonlinear behavior of multiphase flow in a microfluidic device and the effect of several parameters on it. Hence, designing a flexible way to predict the
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Application of microfluidic devices for glioblastoma study: current status and future directions. Biomed. Microdevices (IF 2.176) Pub Date : 2020-09-01 Xue Cai,Robert G Briggs,Hannah B Homburg,Isabella M Young,Ethan J Davis,Yueh-Hsin Lin,James D Battiste,Michael E Sughrue
Glioblastoma (GBM) is one of the most malignant primary brain tumors. This neoplasm is the hardest to treat and has a bad prognosis. Because of the characteristics of genetic heterogeneity and frequent recurrence, a successful cure for the disease is unlikely. Increasing evidence has revealed that the GBM stem cell-like cells (GSCs) and microenvironment are key elements in GBM recurrence and treatment
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Effect of temperature and ultraviolet light on the bacterial kill effectiveness of antibiotic-infused 3D printed implants. Biomed. Microdevices (IF 2.176) Pub Date : 2020-08-26 Shivakumar I Ranganathan,Christopher Kohama,Theo Mercurio,Alec Salvatore,Mohammed Mehdi Benmassaoud,Tae Won B Kim
Drug eluting 3D printed polymeric implants have great potential in orthopaedic applications since they are relatively inexpensive and can be designed to be patient specific thereby providing quality care. Fused Deposition Modeling (FDM) and Stereolithography (SLA) are among the most popular techniques available to print such polymeric implants. These techniques facilitate introducing antibiotics into
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Pumpless microfluidic device with open top cell culture under oscillatory shear stress. Biomed. Microdevices (IF 2.176) Pub Date : 2020-08-24 Zhehuan Chen,Jenny Zilberberg,Woo Lee
Here we developed a 96-well plate-based pumpless microfluidic device to mimic bidirectional oscillatory shear stress experienced by osteoblasts at the endosteal niche located at the interface between bone and bone marrow. The culture device was designed to be high-throughput with 32 open top culture chambers for convenient cell seeding and staining. Mathematical modeling was used to simulate the control
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Totally transparent hydrogel-based subdural electrode with patterned salt bridge. Biomed. Microdevices (IF 2.176) Pub Date : 2020-08-22 Ayaka Nishimura,Ryota Suwabe,Yuka Ogihara,Shotaro Yoshida,Hiroya Abe,Shin-Ichiro Osawa,Atsuhiro Nakagawa,Teiji Tominaga,Matsuhiko Nishizawa
A totally transparent subdural electrode was developed by embedding a conductive poly (vinyl alcohol) (PVA)-filled microchannel made of poly(dimethylsiloxane) (PDMS) into an another PVA hydrogel substrate. Tight bonding between the PVA substrate and the PDMS microchannel (salt bridge) was achieved by mechanical interlocking utilizing the microprotrusions formed on the microchannel. This simple method
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In-situ electromechanical testing and loading system for dynamic cell-biomaterial interaction study. Biomed. Microdevices (IF 2.176) Pub Date : 2020-08-21 Lingda Meng,Guilan Xue,Qingjie Liu,Tianpeng Xie,Duan Fan,Xue Gou
The mechanical and electrical properties of biomaterials are essential in cell function regulation during cell-biomaterial interaction. However, previous studies focused on probing cell regulation mechanisms under one type of stimulus, and a platform that enables the study of electromechanical coupling effects of a biomaterial on cells is still lacking. Here, we present an in-situ electromechanical
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Recent advances in microfluidic technologies for separation of biological cells. Biomed. Microdevices (IF 2.176) Pub Date : 2020-08-14 Lujing Sun,Wenguang Yang,Shuxiang Cai,Yibao Chen,Honghui Chu,Haibo Yu,Yuechao Wang,Lianqing Liu
Cell separation has always been a key topic in academic research, especially in the fields of medicine and biology, due to its significance in diagnosis and treatment. Accurate, high-throughput and non-invasive separation of individual cells is key to driving the development of biomedicine and cellular biology. In recent years, a series of researches on the use of microfluidic technologies for cell
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Modelling on mutual inductance of wireless power transfer for capsule endoscopy. Biomed. Microdevices (IF 2.176) Pub Date : 2020-08-13 Shuai Kuang,Guozheng Yan
Wireless capsule endoscopy (WCE) is noninvasive, painless, and riskless on detection for gastrointestinal disease. It attracts increasing attention. Wireless power transfer (WPT) technology is utilized to supply power for WCE. Receiving coil (RC) of WPT is capsulated into WCE. Its position and direction change all through gastrointestinal tract. Transmitting coil (TC) is worn by the patient. So the
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Wireless, battery-free and wearable device for electrically controlled drug delivery: sodium salicylate released from bilayer polypyrrole by near-field communication on smartphone. Biomed. Microdevices (IF 2.176) Pub Date : 2020-08-11 Jinglong Liu,Zhaoyang Liu,Xin Li,Lihang Zhu,Gang Xu,Zetao Chen,Chen Cheng,Yanli Lu,Qingjun Liu
Compared with traditional drug delivery methods, transdermal drug delivery has many advantages in avoiding the side effects in gastrointestinal tract, reducing the fluctuations in drug concentration, and improving patients’ compliance. Among them, electrically controlled drug delivery is a promising solution. This work presents a wireless, battery-free and wearable device with electrically controlled
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Inertial flow focusing: a case study in optimizing cellular trajectory through a microfluidic MEMS device for timing-critical applications. Biomed. Microdevices (IF 2.176) Pub Date : 2020-08-08 Luke H C Patterson,Jennifer L Walker,Mark A Naivar,Evelyn Rodriguez-Mesa,Mehran R Hoonejani,Kevin Shields,John S Foster,Adele M Doyle,Megan T Valentine,Kimberly L Foster
Although microfluidic micro-electromechanical systems (MEMS) are well suited to investigate the effects of mechanical force on large populations of cells, their high-throughput capabilities cannot be fully leveraged without optimizing the experimental conditions of the fluid and particles flowing through them. Parameters such as flow velocity and particle size are known to affect the trajectories of
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Ultrasensitive covalently-linked Aptasensor for cocaine detection based on electrolytes-induced repulsion/attraction of colloids. Biomed. Microdevices (IF 2.176) Pub Date : 2020-08-03 Serdar Sanli,Hichem Moulahoum,Faezeh Ghorbanizamani,Emine Guler Celik,Suna Timur
A quick and easy colorimetric sensor based on gold nanoparticles (GNPs) and aptamers for the detection of cocaine was developed. The sensor was named as ‘GAPTA’ and showed extremely interesting results regarding cocaine detection with a sensitivity to doses of 0.2 nM. The experimental approach consisted of creating a conjugate between GNPs (10 nm size) and aptamers as a sensing base with the addition
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Carbon nanotube-based thin-film resistive sensor for point-of-care screening of tuberculosis. Biomed. Microdevices (IF 2.176) Pub Date : 2020-07-28 Seong-Joong Kahng,Scott D Soelberg,Fabrice Fondjo,Jong-Hoon Kim,Clement E Furlong,Jae-Hyun Chung
For point-of-care diagnosis of tuberculosis (TB), current TB diagnostic approaches need to be further improved for achieving an accurate diagnosis that is rapid and low-cost. This paper presents an immuno-resistive sensor on a plastic film for inexpensive, simple TB screening. The sensor is composed of single-walled carbon nanotubes (SWCNTs) functionalized with polyclonal antibodies raised against
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Hydrogel-based sealed microchamber arrays for rapid medium exchange and drug testing of cell spheroids. Biomed. Microdevices (IF 2.176) Pub Date : 2020-07-27 Shotaro Yoshida,Kensuke Sumomozawa,Kuniaki Nagamine,Matsuhiko Nishizawa
Culturing cell spheroids in microchamber arrays is a widely used method in regenerative medicine and drug discovery while it requires laborious procedures during medium exchange and drug administration. Here, we report a simple method for the medium exchange and drug testing using a hydrogel-based sealed microchamber arrays. Owing to the high molecular permeability of poly(vinyl alcohol) hydrogel,
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Microfluidic Chip based direct triple antibody immunoassay for monitoring patient comparative response to leukemia treatment. Biomed. Microdevices (IF 2.176) Pub Date : 2020-07-13 Kutay İçöz,Ünal Akar,Ekrem Ünal
We report a time and cost-efficient microfluidic chip for screening the leukemia cells having three specific antigens. In this method, the target blast cells are double sorted with immunomagnetic beads and captured by the 3rd antibody immobilized on the gold surface in a microfluidic chip. The captured blast cells in the chip were imaged using a bright-field optical microscope and images were analyzed
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A hybrid electrically-and-piezoelectrically driven micromixer built on paper for microfluids mixing. Biomed. Microdevices (IF 2.176) Pub Date : 2020-07-08 Yanfang Guan,Fengqian Xu,Baichuan Sun,Xiangxin Meng,Yansheng Liu,Mingyang Bai
This study aims to explore the channel patterns and the characteristic parameters of the zigzag microchannel based on microfluidic paper-based analytical devices (μPADs), in which the mixing efficiency and speed can be greatly enhanced. Better mixing of the solutions was obtained by adding a simple directing electric field to the optimized structure of the zigzag microchannel on paper-based chips instead
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Vitreous protein binding with nanopore dialysis membrane device. Biomed. Microdevices (IF 2.176) Pub Date : 2020-07-04 Jeffrey L Olson,Raul Velez-Montoya,Anna Mackin,Niranjan Manoharan,Niklaus Mueller,Michael Erlanger
Age-related macular degeneration (AMD) is one of the leading causes of blindness in the industrialized world, affecting over 8 million patients in the United State alone. While the wet (exudative) form of the disease is treated with intraocular injections, there are currently no approved therapies available for the dry (non-exudative) form of the disease which often affects both eyes in patients with
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Label free Impedimetric Immunosensor for effective bladder Cancer detection in clinical urine samples. Biomed. Microdevices (IF 2.176) Pub Date : 2020-06-30 Muhammad Omar Shaikh,Ting-Chi Huang,Ting-Feng Wu,Cheng-Hsin Chuang
Galectin-1 protein has been recently recognized as a valuable urinary biomarker for the diagnosis and prognosis of bladder cancer. Herein, we present a sensitive and specific impedimetric immunosensor for the quantitative and label free detection of Galectin-1 protein in clinical urine samples. The immunosensor consists of nine gold interdigitated microelectrodes (3 × 3 array), which can simultaneously
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Poly-L-histidine coated microfluidic devices for bacterial DNA purification without chaotropic solutions. Biomed. Microdevices (IF 2.176) Pub Date : 2020-06-22 Athina S Kastania,Panagiota S Petrou,Christos-Moritz Loukas,Evangelos Gogolides
We present a disposable polymeric microfluidic device capable of reversibly binding and purifying Salmonella DNA through solid phase extraction (SPE). The microfluidic channels are first oxygen plasma treated and simultaneously micro-nanotextured, and then functionalized with amine groups via modification with L-histidine or poly-L-histidine. L-Histidine and poly-L-histidine bind on the plasma treated
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Penetrating glassy carbon neural electrode arrays for brain-machine interfaces. Biomed. Microdevices (IF 2.176) Pub Date : 2020-06-06 Biao Chen,Boshen Zhang,Chaoyang Chen,Jie Hu,Jin Qi,Tao He,Pan Tian,Xinuo Zhang,Guoxin Ni,Mark Ming-Cheng Cheng
This paper presents a fabrication method for glassy carbon neural electrode arrays that combines 3D printing and chemical pyrolysis technology. The carbon electrodes have excellent biological compatibility and can be used in neural signal recording. A pretreated Si wafer is used as the substrate for 3D printing, and then, stereolithography 3D printing technology is employed to print photosensitive
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Effect of angle-of-attacks on deterministic lateral displacement (DLD) with symmetric airfoil pillars. Biomed. Microdevices (IF 2.176) Pub Date : 2020-06-03 Kawkab Ahasan,Christopher M Landry,Xiaolin Chen,Jong-Hoon Kim
Deterministic lateral displacement (DLD) is a microfluidic technique for size fractionation of particles/cells in continuous flow with a great potential for biological and clinical applications. Growing interest of DLD devices in enabling high-throughput operation for practical applications, such as circulating tumor cell (CTC) separation, necessitates employing higher flow rates, leading to operation
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Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity. Biomed. Microdevices (IF 2.176) Pub Date : 2020-06-03 Hannu Välimäki,Tanja Hyvärinen,Joni Leivo,Haider Iftikhar,Mari Pekkanen-Mattila,Dhanesh Kattipparambil Rajan,Jarmo Verho,Joose Kreutzer,Tomi Ryynänen,Jonatan Pirhonen,Katriina Aalto-Setälä,Pasi Kallio,Susanna Narkilahti,Jukka Lekkala
Luminescence-based oxygen sensing is a widely used tool in cell culture applications. In a typical configuration, the luminescent oxygen indicators are embedded in a solid, oxygen-permeable matrix in contact with the culture medium. However, in sensitive cell cultures even minimal leaching of the potentially cytotoxic indicators can become an issue. One way to prevent the leaching is to immobilize
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High-throughput cell migration assay under combinatorial chemical environments by a novel 24-well-plate based device. Biomed. Microdevices (IF 2.176) Pub Date : 2020-05-30 Jian Xu,Xudong Wang,Xiao Li,Gen Yang,Chunxiong Luo
The quantitative studies of cell proliferation and migration under different chemical environments are important for both scientists and clinicians searching for new therapeutics. In this study, we developed a new device to pattern several types of cells in 24-well-plate and demonstrated its’ application in cancer cell proliferation and migration assay. The new device combined 3D-printed-silica-part
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An immunoassay cassette with a handheld reader for HIV urine testing in point-of-care diagnostics. Biomed. Microdevices (IF 2.176) Pub Date : 2020-05-21 Wenbo Yang,Dianlong Yang,Shisong Gong,Xiaobing Dong,Luyao Liu,Shengda Yu,Xiaolei Zhang,Shengxiang Ge,Dong Wang,Ningshao Xia,Duli Yu,Xianbo Qiu
Currently, most HIV tests are performed with blood samples, or alternatively saliva samples are used for HIV testing. Simple HIV tests need to be performed in hospitals or other medical agencies instead of more invasive HIV blood tests. To enable point-of-care (POC) HIV diagnostics, based on a recently developed lateral flow strip for HIV urine testing, a microfluidic immunoassay cassette with a handheld
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On-chip estimation of hematocrit level for diagnosing anemic conditions by Impedimetric techniques. Biomed. Microdevices (IF 2.176) Pub Date : 2020-05-20 Subhadip Chakraborty,Sreyasi Das,Chirantan Das,Soumyak Chandra,Kaushik Das Sharma,Anupam Karmakar,Sanatan Chattoapadhyay
An on-chip device has been fabricated on Si platform for precise estimation of the hematocrit (Hct) level of human blood with rapid turn out. Impedance/capacitance spectroscopy and current-voltage (I-V) measurements have been employed to observe the variation of electrical parameters of erythrocyte suspensions with varying Hct level. Experimentally obtained values of capacitance, impedance and conductance
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Development and characterization of a PDMS-based masking method for microfabricated Oral drug delivery devices. Biomed. Microdevices (IF 2.176) Pub Date : 2020-05-18 Khorshid Kamguyan,Lasse Højlund Eklund Thamdrup,Lukas Vaut,Line Hagner Nielsen,Kinga Zor,Anja Boisen
With the growing popularity and application of microfabricated devices in oral drug delivery (ODD), masking technologies for drug loading and surface modification become highly relevant. Considering the speed of design and fabrication processes and the necessity for continuous alterations of e.g. the shape and sizes of the devices during the optimization process, there is a need for adaptable, precise
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3D-Printed micro-optofluidic device for chemical fluids and cells detection. Biomed. Microdevices (IF 2.176) Pub Date : 2020-05-18 Fabiana Cairone,Santi Davi,Giovanna Stella,Francesca Guarino,Giuseppe Recca,Gianluca Cicala,Maide Bucolo
In this work, it is presented a micro-optofluidic flow detector used for on-chip biological and chemical samples investigation. It is made in Poly-dimethyl-siloxane using a master-slave approach based on the 3D-Printing techniques. The micro-optofluidic device is made by assembling a microfluidic T-junction with a micro-optical section that consists of two optical fiber insertions and a PDMS gold-spattered
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Simultaneous electrical detection of IL-6 and PCT using a microfluidic biochip platform. Biomed. Microdevices (IF 2.176) Pub Date : 2020-05-18 Jacob Berger,Enrique Valera,Aaron Jankelow,Carlos Garcia,Manik Akhand,John Heredia,Tanmay Ghonge,Cynthia Liu,Victor Font-Bartumeus,Gina Oshana,Justin Tiao,Rashid Bashir
Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response, leads the U.S in both mortality rate and cost of treatment. Sepsis treatment protocols currently rely on broad and non-specific parameters like heart and respiration rate, and temperature; however, studies show that biomarkers Interlukin-6 (IL-6) and Procalcitonin (PCT) correlate to sepsis progression and response
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Biomimetic aorta-gonad-Mesonephros-on-a-Chip to study human developmental hematopoiesis. Biomed. Microdevices (IF 2.176) Pub Date : 2020-05-06 Ryohichi Sugimura,Ryo Ohta,Chihiro Mori,Alina Li,Takafumi Mano,Emi Sano,Kaori Kosugi,Tatsutoshi Nakahata,Akira Niwa,Megumu K Saito,Yu-Suke Torisawa
A fundamental limitation in the derivation of hematopoietic stem and progenitor cells is the imprecise understanding of human developmental hematopoiesis. Herein we established a multilayer microfluidic Aorta-Gonad-Mesonephros (AGM)-on-a-chip to emulate developmental hematopoiesis from pluripotent stem cells. The device consists of two layers of microchannels separated by a semipermeable membrane,
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Optical measurement platform of temperature-dependent interaction between nanoliposomes and a polymer-grafted surface. Biomed. Microdevices (IF 2.176) Pub Date : 2020-05-04 Virendra Majarikar,Hiroaki Takehara,Takanori Ichiki
In this study, we report an opto-microfluidic platform integrated with dark-field light scattering imaging and fluorescence microspectroscopy to investigate the temperature-dependent behavior of nanoliposomes. This newly developed experimental platform enabled both in situ measurements of the temperature of the sample solution and observation of individual nanoliposomes. As a proof-of-concept, the
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Rapid lipid bilayer membrane formation on Parylene coated apertures to perform ion channel analyses. Biomed. Microdevices (IF 2.176) Pub Date : 2020-04-30 Tanzir Ahmed,Sander van den Driesche,Jayesh Arun Bafna,Martin Oellers,Roland Hemmler,Karsten Gall,Richard Wagner,Mathias Winterhalter,Michael J Vellekoop
We present a chip design allowing rapid and robust lipid bilayer (LBL) membrane formation using a Parylene coated thin silicon nitride aperture. After bilayer formation, single membrane channels can be reconstituted and characterized by electrophysiology. The ability for robust reconstitution will allow parallelization and enhanced screening of small molecule drugs acting on or permeating across the
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