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Nano-Drug Delivery Systems Targeting CAFs: A Promising Treatment for Pancreatic Cancer Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-18 Mingjie Wang, Wenxiang Xue, Hanghang Yuan, Zhicheng Wang, Lei Yu
Abstract: Currently, pancreatic cancer (PC) is one of the most lethal malignant tumors. PC is typically diagnosed at a late stage, exhibits a poor response to conventional treatment, and has a bleak prognosis. Unfortunately, PC’s survival rate has not significantly improved since the 1960s. Cancer-associated fibroblasts (CAFs) are a key component of the pancreatic tumor microenvironment (TME). They
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Influence of Different Ratios of DSPE-PEG2k on Ester Prodrug Self-Assembly Nanoparticles for Cell Migration and Proliferation Suppression Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-18 Huiyun Zhang, Shunru Wei, Yunfei Hu, Yu Zhang, Hao Yao, Gang Qi, Michael Adu-Frimpong, Congyong Sun
Background: Bufalin (BFL, an active anti-tumor compound derived from toad venom) is limited in its application due to high toxicity and rapid metabolism of the cardiotonic steroid. Ester prodrug self-assembly nanoparticles have shown significant improved effects in addressing the above-mentioned issues. Methods: An ester bond was formed between linoleic acid and bufalin to synthesize linoleic acid-bufalin
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Targeted Ultrasound Nanobubbles Therapy for Prostate Cancer via Immuno-Sonodynamic Effect Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-18 Xin Huang, Yueying Chen, Fanglu Zhong, Bin Gui, Yugang Hu, Yuxin Guo, Qing Deng, Qing Zhou
Background: Prostate cancer (PCa) poses a significant global health threaten. Immunotherapy has emerged as a novel strategy to augment the inhibition of tumor proliferation. However, the sole use of anti-PD-L1 Ab for PCa has not yielded improvements, mirroring outcomes observed in other tumor types. Methods: This study employed the thin film hydration method to develop lipid nanobubbles (NBs) encapsulating
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Emerging Strategies to Overcome Current CAR-T Therapy Dilemmas - Exosomes Derived from CAR-T Cells Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-18 Dong Hu, Ruyue Yang, Guidan Wang, Hao Li, Xulong Fan, Gaofeng Liang
Abstract: Adoptive T cells immunotherapy, specifically chimeric antigen receptor T cells (CAR-T), has shown promising therapeutic efficacy in the treatment of hematologic malignancies. As extensive research on CAR-T therapies has been conducted, various challenges have emerged that significantly hampered their clinical application, including tumor recurrence, CAR-T cell exhaustion, and cytokine release
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IL-12-Overexpressed Nanoparticles Suppress the Proliferation of Melanoma Through Inducing ICD and Activating DC, CD8+ T, and CD4+ T Cells Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-18 Huan-Huan Shen, Jie-Fei Peng, Ran-Ran Wang, Ping-Yu Wang, Jia-Xiang Zhang, Hong-Fang Sun, Yan Liang, Yan-Mei Li, Jiang-Nan Xue, You-Jie Li, Guang-Bin Sun, Shu-Yang Xie
Purpose: The drug resistance and low response rates of immunotherapy limit its application. This study aimed to construct a new nanoparticle (CaCO3-polydopamine-polyethylenimine, CPP) to effectively deliver interleukin-12 (IL-12) and suppress cancer progress through immunotherapy. Methods: The size distribution of CPP and its zeta potential were measured using a Malvern Zetasizer Nano-ZS90. The morphology
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The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-16 Tingting Chen, Zimei Wu, Qiaodan Hou, Yixin Mei, Kunkun Yang, Jing Xu, Lin Wang
Purpose: Given the escalating prevalence of diabetes, the demand for specific bone graft materials is increasing, owing to the greater tendency towards bone defects and more difficult defect repair resulting from diabetic bone disease (DBD). Melatonin (MT), which is known for its potent antioxidant properties, has been shown to stimulate both osteogenesis and angiogenesis. Methods: MT was formulated
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Polymeric Nanohydrogel in Topical Drug Delivery System Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-15 Nia Yuniarsih, Anis Yohana Chaerunisaa, Khaled M Elamin, Nasrul Wathoni
Abstract: Nanohydrogels (NH) are biodegradable polymers that have been extensively studied and utilized for various biomedical applications. Drugs in a topical medication are absorbed via the skin and carried to the intended location, where they are metabolized and eliminated from the body. With a focus on their pertinent contemporary treatments, this review aims to give a complete overview of recent
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Utilization of Nitrogen-Doped Graphene Quantum Dots to Neutralize ROS and Modulate Intracellular Antioxidant Pathways to Improve Dry Eye Disease Therapy Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-15 Zixia Wu, Weibo Xia, Liling Ou, Ling Zheng, Bingying Hou, Tonghe Pan, Wenjie Sun, Leo H Koole, Yongqing Shao, Lei Qi
Purpose: Patients afflicted with dry eye disease (DED) experience significant discomfort. The underlying cause of DED is the excessive accumulation of ROS on the ocular surface. Here, we investigated the nitrogen doped-graphene quantum dots (NGQDs), known for their ROS-scavenging capabilities, as a treatment for DED. Methods: NGQDs were prepared by using citric acid and urea as precursors through hydrothermal
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Anti-Tumor Efficacy of Oleuropein-Loaded ZnO/Au Mesoporous Silica Nanoparticle in 5-FU-Resistant Colorectal Cancer Cells Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-14 Sang Mi Park, Da Yeon Kim, Kyeong Hyeon Lee, Yong-Il Shin, Sang-Cheol Han, Sang-Mo Kwon
Purpose: 5-fluorouracil (5-FU) is a first-line chemotherapeutic agent used to treat colorectal cancer (CRC). However, 5-FU induces drug resistance and activation of cancer stem cells (CSCs). In the present study, we designed a novel biocompatible nanomedicine system with high efficacy and biocompatibility by synthesizing mesoporous silica nanoparticle (MSN)-structured ZnO and gold ions. Oleuropein
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Ionizable Lipid Nanoparticle-Mediated TRAIL mRNA Delivery in the Tumor Microenvironment to Inhibit Colon Cancer Progression Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-14 Walison Nunes da Silva, Pedro Augusto Carvalho Costa, Sérgio Ricardo Aluotto Scalzo Júnior, Heloísa AS Ferreira, Pedro Henrique Dias Moura Prazeres, Caroline Leonel Vasconcelos Campos, Marco Túllio Rodrigues Alves, Natália Jordana Alves da Silva, Ana Luiza de Castro Santos, Lays Cordeiro Guimarães, Maria Eduarda Chen Ferris, Ajay Thatte, Alex Hamilton, Kelly Alves Bicalho, Anderson Oliveira Lobo, Helton
Introduction: Immunotherapy has revolutionized cancer treatment by harnessing the immune system to enhance antitumor responses while minimizing off-target effects. Among the promising cancer-specific therapies, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted significant attention. Methods: Here, we developed an ionizable lipid nanoparticle (LNP) platform to deliver TRAIL
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Lipid-Based Self-Microemulsion of Niclosamide Achieved Enhanced Oral Delivery and Anti-Tumor Efficacy in Orthotopic Patient-Derived Xenograft of Hepatocellular Carcinoma in Mice Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-14 Yi Liu, David Quintanar Guerrero, David Lechuga-Ballesteros, Mingdian Tan, Faiz Ahmad, Bilal Aleiwi, Edmund Lee Ellsworth, Bin Chen, Mei-Sze Chua, Samuel So
Introduction: We previously identified niclosamide as a promising repurposed drug candidate for hepatocellular carcinoma (HCC) treatment. However, it is poorly water soluble, limiting its tissue bioavailability and clinical application. To overcome these challenges, we developed an orally bioavailable self-microemulsifying drug delivery system encapsulating niclosamide (Nic-SMEDDS). Methods: Nic-SMEDDS
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Topical Delivery of microRNA-125b by Framework Nucleic Acids for Psoriasis Treatment Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-15 Yunfeng Han, Long Xi, Fang Leng, Chenjie Xu, Ying Zheng
Purpose: Psoriasis is a chronic and recurrent inflammatory dermatitis characterized by T cell imbalance and abnormal keratinocyte proliferation. MicroRNAs (miRNAs) hold promise as therapeutic agents for this disease; however, their clinical application is hindered by poor stability and limited skin penetration. This study demonstrates the utilization of Framework Nucleic Acid (FNA) for the topical
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High-Performance Photodynamic Therapy of Tongue Squamous Cell Carcinoma with Multifunctional Nano-Verteporfin Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-13 Lina Yu, Zidan Xu, Guanxiong Zhu, Liting Zeng, Zeyu Zhang, Yang Yu, Siran Wang, Xin Zhang, Na Zhou, Lu Liang
Background: The photodynamic therapy (PDT) showed promising potential in treating tongue squamous cell carcinoma (TSCC). The Food and Drug Administration approved Verteporfin (Ver) is a powerful alternative in this field for its penetrating power and high production of reactive oxygen species (ROS). However, its applications in the treatment of TSCC are still rare. Methods: Ver was loaded onto Poly
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Emerging Drug Delivery Vectors: Engineering of Plant-Derived Nanovesicles and Their Applications in Biomedicine Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-13 Lu-Yao Yang, Chao-Qing Li, Yu-Lin Zhang, Meng-Wen Ma, Wan Cheng, Guo-Jun Zhang
Abstract: Extracellular vesicles can transmit intercellular information and transport biomolecules to recipient cells during various pathophysiological processes in the organism. Animal cell exosomes have been identified as potential nanodrugs delivery vehicles, yet they have some shortcomings such as high immunogenicity, high cytotoxicity, and complicated preparation procedures. In addition to exosomes
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Oriented Graphene Oxide Scaffold Promotes Nerve Regeneration in vitro and in vivo Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-13 Xu Zhou, Aolin Tang, Chengjie Xiong, Guoquan Zhang, Liangliang Huang, Feng Xu
Background: Treating peripheral nerve injuries (PNI) with defects remains challenging in clinical practice. The commercial conduits have shown suboptimal nerve regeneration and functional recovery due to their basic tubular design without electroactive and oriented topographical cues. Purpose: To develop a new scaffold with oriented microstructure and electroactive Graphene oxide (GO) and investigate
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Targeted Delivery of Mesenchymal Stem Cell-Derived Bioinspired Exosome-Mimetic Nanovesicles with Platelet Membrane Fusion for Atherosclerotic Treatment Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-13 Yu Jiang, Miao Yu, Zhi-Feng Song, Zhi-Yao Wei, Ji Huang, Hai-Yan Qian
Purpose: Accumulating evidence indicates that mesenchymal stem cells (MSCs)-derived exosomes hold significant potential for the treatment of atherosclerosis. However, large-scale production and organ-specific targeting of exosomes are still challenges for further clinical applications. This study aims to explore the targeted efficiency and therapeutic potential of biomimetic platelet membrane-coated
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Nanoparticle-Based Combinational Strategies for Overcoming the Blood-Brain Barrier and Blood-Tumor Barrier Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-13 Su Hyun Lim, Gi Taek Yee, Dongwoo Khang
Abstract: The blood-brain barrier (BBB) and blood-tumor barrier (BTB) pose substantial challenges to efficacious drug delivery for glioblastoma multiforme (GBM), a primary brain tumor with poor prognosis. Nanoparticle-based combinational strategies have emerged as promising modalities to overcome these barriers and enhance drug penetration into the brain parenchyma. This review discusses various nanoparticle-based
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Exploiting Nanotechnology for Drug Delivery: Advancing the Anti-Cancer Effects of Autophagy-Modulating Compounds in Traditional Chinese Medicine Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-12 Zixian Liu, Tianming Lu, Ruoning Qian, Zian Wang, Ruogu Qi, Zhengguang Zhang
Background: Cancer continues to be a prominent issue in the field of medicine, as demonstrated by recent studies emphasizing the significant role of autophagy in the development of cancer. Traditional Chinese Medicine (TCM) provides a variety of anti-tumor agents capable of regulating autophagy. However, the clinical application of autophagy-modulating compounds derived from TCM is impeded by their
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Design and Self-Assembly of Peptide-Copolymer Conjugates into Nanoparticle Hydrogel for Wound Healing in Diabetes Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-09 Yiling Lin, Yingneng Zhang, Xia Cai, Huashen He, Chuangzan Yang, Junfeng Ban, Bohong Guo
Background: Delayed wound healing in skin injuries has become a significant problem in clinics, seriously affecting and even threatening life and health. Recently, research interest has increased in developing wound dressings containing bioactive compounds capable of improving outcomes for complex healing needs. Methods: In this study, Puerarin-loaded nanoparticles (Pue-NPs) were prepared using the
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Highly Ordered Nanotube-Like Microstructure on Titanium Dental Implant Surface Fabricated via Anodization Enhanced Cell Adhesion and Migration of Human Gingival Fibroblasts Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-08 Zhaoming Deng, Lerong Yu, Yishen Kuang, Ziyao Zhou, Xiangwei Li
Background: Titanium (Ti) surface with nanotubes array via anodization has been used in dental implants to enhance bone regeneration but little research was carried out to evaluate whether the presence of highly ordered or disorderly distributed nanotubes array on titanium surface would have an effect on cell behaviors of gingival fibroblasts. Methods: The present study fabricated nanotubes arrays
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How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-08 Priyadarshini Mohapatra, Mohanraj Gopikrishnan, George Priya Doss C, Natarajan Chandrasekaran
Abstract: New nanotechnology strategies for enhancing drug delivery in brain disorders have recently received increasing attention from drug designers. The treatment of neurological conditions, including brain tumors, stroke, Parkinson’s Disease (PD), and Alzheimer’s disease (AD), may be greatly influenced by nanotechnology. Numerous studies on neurodegeneration have demonstrated the effective application
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A SARS-CoV-2 Nanobody Displayed on the Surface of Human Ferritin with High Neutralization Activity Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-08 Wenrong Zhang, Haining Wang, Tong Wu, Xintao Gao, Yuting Shang, Zhifang Zhang, Xingjian Liu, Yinü Li
Purpose: COVID-19 is rampant throughout the world, which has caused great damage to human lives and seriously hindered the development of the global economy. Aiming at the treatment of SARS-CoV-2, in this study, we proposed a novel fenobody strategy based on ferritin (Fe) self-assembly technology. Methods: The neutralizing nanobody H11-D4 of SARS-CoV-2 fused to the C-terminus of end-modified human
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Dual-Stimuli-Responsive Gut Microbiota-Targeting Nitidine Chloride-CS/PT-NPs Improved Metabolic Status in NAFLD Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-08 Jianmei Lu, Yongzhu Zeng, Huashuai Zhong, Wei Guo, Yuyan Zhang, Wanting Mai, Yucui Qin, Xiaodan Su, Bo Zhang, Weisen Wu, Yu Zhu, Qiujie Huang, Yong Ye
Background and Purpose: Nitidine chloride (NC) is a botanical drug renowned for its potent anti-inflammatory, antimalarial, and hepatocellular carcinoma-inhibiting properties; however, its limited solubility poses challenges to its development and application. To address this issue, we have devised a colon-targeted delivery system (NC-CS/PT-NPs) aimed at modulating the dysbiosis of the gut microbiota
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Pioneering Astaxanthin-Tumor Cell Membrane Nanoparticles for Innovative Targeted Drug Delivery on Melanoma Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-07 Jui-Jen Chang, Yi-Chen Wang, Shu-Hui Yang, Ju-Yu Wu, Ming-Wei Chang, Hui-Min David Wang
Background: Recently, the use of the tumor or its secretions as drug carriers has gradually become popular, with the advantages of high biocompatibility and enhanced drug delivery to specific cells. Melanoma is the most malignant tumor of all skin cancers; it is the most metastatic and, therefore, the most difficult to treat. The main purpose of this study is to develop nanovesicles with tumor cell
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Engineered Extracellular Vesicles in Chronic Kidney Diseases: A Comprehensive Review Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-07 Kaming Xue, Bobin Mi
Abstract: Chronic kidney diseases (CKD) present a formidable global health challenge, characterized by a deficiency of effective treatment options. Extracellular vesicles (EVs), recognized as multifunctional drug delivery systems in biomedicine, have gained accumulative interest. Specifically, engineered EVs have emerged as a promising therapeutic approach for targeted drug delivery, potentially addressing
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Potential Exploration of Biocompatible Carbon-Coated MoSe2 Nanoparticles for Exploration of the Photothermal Potential in the Treatment of Human Choriocarcinoma Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-07 Hui Yu, Xinyi He, Jinmeng Yao, Xiaoya Gu, Lin Zhou, Li Gao, Jia Wang
Background: Molybdenum diselenide (MoSe2), as a nano near-infrared absorber, has been widely studied in the field of photothermal therapy of cancer. However, there is little research on its application in the treatment of human choriocarcinoma. Methods and Results: In this paper, a new type of carbon-coated MoSe2 (MEC) nanoparticles was prepared by a one-step hydrothermal method. The chemical characterization
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Reduced Graphene Oxide Fibers Combined with Electrical Stimulation Promote Peripheral Nerve Regeneration Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-07 Yuanyuan Zhao, Yang Liu, Cheng Lu, Daokuan Sun, Shiqi Kang, Xin Wang, Laijin Lu
Background: The treatment of long-gap peripheral nerve injury (PNI) is still a substantial clinical problem. Graphene-based scaffolds possess extracellular matrix (ECM) characteristic and can conduct electrical signals, therefore have been investigated for repairing PNI. Combined with electrical stimulation (ES), a well performance should be expected. We aimed to determine the effects of reduced graphene
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Polymersomes for Therapeutic Protein and Peptide Delivery: Towards Better Loading Properties Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-07 Chengxu Hua, Liyan Qiu
Abstract: Therapeutics based on proteins and peptides have profoundly transformed the landscape of treatment for diseases, from diabetes mellitus to cancers, yet the short half-life and low bioavailability of therapeutic proteins and peptides hinder their wide applications. To break through this bottleneck, biomolecules-loaded polymersomes with strong adjustability and versatility have attracted more
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Glutathione Depletion-Induced ROS/NO Generation for Cascade Breast Cancer Therapy and Enhanced Anti-Tumor Immune Response Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-07 Jing Wang, Yanxiang Sang, Weijian Chen, Liang Cheng, Wenxiang Du, Hongjie Zhang, Benyan Zheng, Lei Song, Yuan Hu, Xiaopeng Ma
Introduction: As an effective alternative choice to traditional mono-therapy, multifunctional nanoplatforms hold great promise for cancer therapy. Based on the strategies of Fenton-like reactions and reactive oxygen species (ROS)-mediated therapy, black phosphorus (BP) nanoplatform BP@Cu2O@L-Arg (BCL) co-assembly of cuprous oxide (Cu2O) and L-Arginine (L-Arg) nanoparticles was developed and evaluated
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Recombinant Human Heavy Chain Ferritin Nanoparticles Serve as ROS Scavengers for the Treatment of Ischemic Stroke Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-08 Mi Qi, Yajuan Cheng, Ke Liu, Jingxing Cai, Tianyu Liu, Xiaoying Wu, Huili Tang, He Huang, Qinbiao Chen, Xiaoguang Zhou
Purpose: Ischemic stroke is a high-incidence disease that threatens human well-being. The potent neuroprotective effects render reactive oxygen species (ROS) scavengers potential agents for acute ischemic stroke therapy. Challenges such as inadequate permeability across the blood-brain barrier (BBB), limited half-life, and adverse effects hinder the widespread utilization of small molecule and inorganic
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Chitosan-Rapamycin Carbon Dots Alleviate Glaucomatous Retinal Injury by Inducing Autophagy to Promote M2 Microglial Polarization Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-06 Qi Wang, Jiaxin Dong, Mengxian Du, Xinna Liu, Shiqi Zhang, Di Zhang, Wanyun Qin, Xikun Xu, Xianghui Li, Ruidong Su, Leyi Qiu, Baoqiang Li, Huiping Yuan
Introduction: Glaucoma is a prevalent cause of irreversible vision impairment, characterized by progressive retinal ganglion cells (RGCs) loss, with no currently available effective treatment. Rapamycin (RAPA), an autophagy inducer, has been reported to treat glaucoma in rodent models by promoting RGC survival, but its limited water solubility, systemic toxicity, and pre-treatment requirements hinder
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Extracellular Vesicles: A New Star for Gene Drug Delivery Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-06 Man Sun, Huan Zhang, Jiayi Liu, Jiayi Chen, Yaxin Cui, Simiao Wang, Xiangyu Zhang, Zhaogang Yang
Abstract: Recently, gene therapy has become a subject of considerable research and has been widely evaluated in various disease models. Though it is considered as a stand-alone agent for COVID-19 vaccination, gene therapy is still suffering from the following drawbacks during its translation from the bench to the bedside: the high sensitivity of exogenous nucleic acids to enzymatic degradation; the
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Drug-Loaded Tumor-Derived Microparticles Elicit CD8+ T Cell-Mediated Anti-Tumor Response in Hepatocellular Carcinoma Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-06 Yulin Chen, Yi Zhang, Jianjun Wang, Xiong Cai, Junzhang Chen, Xiaobo Min, Yunjie Xu, Qi Qin, Chidan Wan
Background: Hepatocellular Carcinoma (HCC) poses significant challenges due to limited effective treatments and high recurrence rates. Immunotherapy, a promising approach, faces obstacles in HCC patients due to T-cell exhaustion and immunosuppression within the tumor microenvironment. Methods: Using doxorubicin-loaded tumor-derived microparticles (Dox-TMPs), the mice with H22 ascites model and subcutaneous
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Characterization of Drug with Good Glass-Forming Ability Loaded Mesoporous Silica Nanoparticles and Its Impact Toward in vitro and in vivo Studies Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-06 Arif Budiman, Gracia Anastasya, Annisa Luthfiyah Handini, Ira Novianty Lestari, Laila Subra, Diah Lia Aulifa
Abstract: Solid oral dosage forms are mostly preferred in pharmaceutical formulation development due to patient convenience, ease of product handling, high throughput, low manufacturing costs, with good physical and chemical stability. However, 70% of drug candidates have poor water solubility leading to compromised bioavailability. This phenomenon occurs because drug molecules are often absorbed after
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Development of an Intelligent Reactive Oxygen Species-Responsive Dual-Drug Delivery Nanoplatform for Enhanced Precise Therapy of Acute Lung Injury Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-05 Dunling Xia, Zongqing Lu, Shuai Li, Pu Fang, Chun Yang, Xiaoyan He, Qinghai You, Gengyun Sun
Introduction: Acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) are commonly occurring devastating conditions that seriously threaten the respiratory system in critically ill patients. The current treatments improve oxygenation in patients with ALI/ARDS in the short term, but do not relieve the clinical mortality of patients with ARDS. Purpose: To develop the
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Co-Delivery of Aceclofenac and Methotrexate Nanoparticles Presents an Effective Treatment for Rheumatoid Arthritis Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-05 Sushmita Negi, Nikunj Tandel, Neeraj K Garg, Prakriti Sharma, Rajinder Kumar, Praveen Sharma, Reetesh Kumar, Sheetal Saini, Aman Sharma, Rajeev K Tyagi
Background: Rheumatoid arthritis (RA) is a common acute inflammatory autoimmune connective tissue arthropathy. The genetic studies, tissue analyses, experimental animal models, and clinical investigations have confirmed that stromal tissue damage and pathology driven by RA mounts the chronic inflammation and dysregulated immune events. Methods: We developed methotrexate (MTX)-loaded lipid-polymer hybrid
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Bare-Metal Stent Tracking with Magnetic Particle Imaging Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-05 Franz Wegner, Thomas Friedrich, Maximilian Wattenberg, Justin Ackers, Malte Maria Sieren, Roman Kloeckner, Joerg Barkhausen, Thorsten M Buzug, Matthias Graeser, Anselm von Gladiss
Purpose: Magnetic particle imaging (MPI) is an emerging medical imaging modality that is on the verge of clinical use. In recent years, cardiovascular applications have shown huge potential like, e.g., intraprocedural imaging guidance of stent placement through MPI. Due to the lack of signal generation, nano-modifications have been necessary to visualize commercial medical instruments until now. In
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Shear Bond Strength to Enamel, Mechanical Properties and Cellular Studies of Fiber-Reinforced Composites Modified by Depositing SiO2 Nanofilms on Quartz Fibers via Atomic Layer Deposition Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-05 Fei Shu, Hong Chen, Zhihao Zhang, Zhiyue Dun, Weijin Lv, Wangxinyue Sun, Mei Liu
Introduction: Poor interfacial bonding between the fibers and resin matrix in fiber-reinforced composites (FRCs) is a significant drawback of the composites. To enhance the mechanical properties of FRC, fibers were modified by depositing SiO2 nanofilms via the atomic layer deposition (ALD) technique. This study aims to evaluate the effect of ALD treatment of the fibers on the mechanical properties
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Dissolving Microneedle-Based Cascade-Activation Nanoplatform for Enhanced Photodynamic Therapy of Skin Cancer Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-05 Jinyuan Ma, Zongguang Tai, Ying Li, Yang Li, Jiandong Wang, Tao Zhou, Min Shen, Rujuan Xin, Cuie Shen, Quangang Zhu, Zhongjian Chen
Purpose: Photodynamic therapy (PDT) has been an attractive strategy for skin tumor treatment. However, the hypoxic microenvironment of solid tumors and further O2 consumption during PDT would diminish its therapeutic effect. Herein, we developed a strategy using the combination of PDT and hypoxia-activated bioreductive drug tirapazamine (TPZ). Methods: TPZ was linked to DSPE-PEG-NHS forming DSPE-PEG-TPZ
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Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-05 Debiao Xiang, Lili Zhou, Rui Yang, Fang Yuan, Yilin Xu, Yuan Yang, Yong Qiao, Xin Li
Abstract: Currently, cancer remains one of the most significant threats to human health. Treatment of most cancers remains challenging, despite the implementation of diverse therapies in clinical practice. In recent years, research on the mechanism of ferroptosis has presented novel perspectives for cancer treatment. Ferroptosis is a regulated cell death process caused by lipid peroxidation of membrane
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MSC-Derived Exosomes Mitigate Myocardial Ischemia/Reperfusion Injury by Reducing Neutrophil Infiltration and the Formation of Neutrophil Extracellular Traps Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-05 Yuting Feng, Xue Bao, Jinxuan Zhao, Lina Kang, Xuan Sun, Biao Xu
Introduction: Acute inflammatory storm is a major cause of myocardial ischemia/reperfusion (I/R) injury, with no effective treatment currently available. The excessive aggregation of neutrophils is correlated with an unfavorable prognosis in acute myocardial infarction (AMI) patients. Exosomes derived from mesenchymal stromal cells (MSC-Exo) have certain immunomodulatory potential and might be a therapeutic
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Blood-Nanoparticle Interactions Create a Brain Delivery Superhighway for Doxorubicin Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-05 Zhuoxuan Li, Tatyana Kovshova, Julia Malinovskaya, Julian Knoll, Saeed Shanehsazzadeh, Nadezhda Osipova, Anastasia Chernysheva, Pavel Melnikov, Svetlana Gelperina, Matthias G Wacker
Purpose: This study investigated the brain targeting mechanism of doxorubicin-loaded polybutyl cyanoacrylate (PBCA) nanoparticles, particularly their interactions with the blood-brain barrier (BBB). The BBB protects the brain from drugs in the bloodstream and represents a crucial obstacle in the treatment of brain cancer. Methods: An advanced computer model analyzed the brain delivery of two distinct
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Hydrophilic/Hydrophobic Janus Nanofibers Containing Compound K for Cartilage Regeneration Int. J. Nanomed. (IF 8.0) Pub Date : 2024-03-01 Hyun Ho Shin, Junyoung Park, Yeo-Jin Kim, Donghyeon Kim, Eun-Jung Jin, Ji Hyun Ryu
Introduction: Cartilage regeneration is a challenging issue due to poor regenerative properties of tissues. Electrospun nanofibers hold enormous potentials for treatments of cartilage defects. However, nanofibrous materials used for the treatment of cartilage defects often require physical and/or chemical modifications to promote the adhesion, proliferation, and differentiation of cells. Thus, it is
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Zinc Oxide Nanoparticles Exacerbate Epileptic Seizures by Modulating the TLR4-Autophagy Axis Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-29 Pingyang Ke, Jing Liu, Chengzhi Chen, Sen Luo, Huiwen Gu, Juan Gu, Yan Liu, Yuanlin Ma, Yuan Meng, Liqin Hu, Xin Tian, Fei Xiao
Background: Zinc oxide nanoparticles (ZnO NPs) has been widely used in various fields and has had an important impact on human public health. In addition, it inevitably damages human health, including neurological diseases. Therefore, this study explored the effect of ZnO NPs on epilepsy. Methods: The effect of ZnO NPs on epilepsy was observed by behavioral analysis. TLR4 expression and autophagy related
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Nicorandil-Pretreated Mesenchymal Stem Cell-Derived Exosomes Facilitate Cardiac Repair After Myocardial Infarction via Promoting Macrophage M2 Polarization by Targeting miR-125a-5p/TRAF6/IRF5 Signaling Pathway Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-29 Zhao-Ting Gong, Yu-Yan Xiong, Yu Ning, Rui-Jie Tang, Jun-Yan Xu, Wen-Yang Jiang, Xiao-Song Li, Li-Li Zhang, Cheng Chen, Qi Pan, Meng-Jin Hu, Jing Xu, Yue-Jin Yang
Background: Exosomes derived from bone marrow mesenchymal stem cells (MSC-exo) have been considered as a promising cell-free therapeutic strategy for ischemic heart disease. Cardioprotective drug pretreatment could be an effective approach to improve the efficacy of MSC-exo. Nicorandil has long been used in clinical practice for cardioprotection. This study aimed to investigate whether the effects
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Anti-Cancer Potency of Copper-Doped Carbon Quantum Dots Against Breast Cancer Progression Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-27 Mengqi Wang, Shuting Lan, Wenqi Zhang, Qin Jin, Hua Du, Xiaomei Sun, Lijun He, Xiangyun Meng, Liya Su, Gang Liu
Introduction: The anti-cancer potency of copper-doped carbon quantum dots (Cu-CDs) against breast cancer progression needs more detailed investigations. Methods: With urea and ethylene glycol applied as carbon sources and copper sulfate used as a reactive dopant, Cu-CDs were synthesized in the current study by a one-step hydrothermal synthesis method, followed by the characterization and biocompatibility
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Kaempferia parviflora Extracellular Vesicle Loaded with Clarithromycin for the Treatment of Helicobacter pylori Infection Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-27 Variya Nemidkanam, Wijit Banlunara, Nuntaree Chaichanawongsaroj
Purpose: Kaempferia parviflora extracellular vesicles (KPEVs) have been reported as promising nanovesicles for drug delivery. This study aimed to load clarithromycin (CLA) into KPEVs (KPEVS-CLA) and determine the physical properties, drug-releasing efficiency, gastric cell uptake, anti-H. pylori activities, and anti-inflammatory responses in comparison with free CLA and KPEVs. Methods: The size and
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Development of Curcumin and Turmerone Loaded Solid Lipid Nanoparticle for Topical Delivery: Optimization, Characterization and Skin Irritation Evaluation with 3D Tissue Model Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-26 Beyza Sümeyye Aydin, Ali Asram Sagiroglu, Dilek Ozturk Civelek, Mustafa Gokce, Fatemeh Bahadori
Background: Curcuma longa L., commonly known as turmeric, is renowned for its therapeutic benefits attributed to bioactive compounds, namely curcumin (Cur) and aromatic turmerone (Tur), present in its rhizome. These compounds exhibit diverse therapeutic properties, including anti-inflammatory, antioxidant, and anti-tumor effects. However, the topical application of these compounds has a significant
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Exosomes as Powerful Biomarkers in Cancer: Recent Advances in Isolation and Detection Techniques Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-26 Qiongdan Zhang, Huizhen Wang, Qingyi Liu, Ni Zeng, Gang Fu, Yixing Qiu, Yupei Yang, Hanwen Yuan, Wei Wang, Bin Li
Abstract: Exosomes, small extracellular vesicles derived from cells, are known to carry important bioactive molecules such as proteins, nucleic acids, and lipids. These bioactive components play crucial roles in cell signaling, immune response, and tumor metastasis, making exosomes potential diagnostic biomarkers for various diseases. However, current methods for detecting tumor exosomes face scientific
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Development of Small HN Linked Radionuclide Iodine-125 for Nanocarrier Image Tracing in Mouse Model Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-23 Ronglin Ma, Chunya Ji, Mengdan Shen, Shujuan Xu, Guojia Fan, Chengcheng Wu, Qiang Yu, Linliang Yin
Background: Radionuclides have important roles in clinical tumor radiotherapy as they are used to kill tumor cells or as imaging agents for drug tracing. The application of radionuclides has been developing as an increasing number of nanomaterials are used to deliver radionuclides to tumor areas to kill tumor cells. However, promoting the efficient combination of radionuclides and nanocarriers (NCs)
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Topical Ophthalmic Liposomes Dual-Modified with Penetratin and Hyaluronic Acid for the Noninvasive Treatment of Neovascular Age-Related Macular Degeneration Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-23 Chen Sun, Shuyue Zhang, Nan Xu, Kun Liu, Fang Wei, Xiaoqian Zhang, Jigang Zhang, Shen Gao, Yuan Yu, Xueying Ding
Introduction: Since intrinsic ocular barrier limits the intraocular penetration of therapeutic protein through eye drops, repeated intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents are the standard therapy for neovascular age-related macular degeneration (nAMD), which are highly invasive and may cause particular ocular complications, leading to poor patient compliance
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Nanoparticles for the Treatment of Bone Metastasis in Breast Cancer: Recent Advances and Challenges Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-23 Xianzhe Yu, Lingling Zhu
Abstract: Although the frequency of bone metastases from breast cancer has increased, effective treatment is lacking, prompting the development of nanomedicine, which involves the use of nanotechnology for disease diagnosis and treatment. Nanocarrier drug delivery systems offer several advantages over traditional drug delivery methods, such as higher reliability and biological activity, improved penetration
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LGR5 as a Therapeutic Target of Antibody-Functionalized Biomimetic Magnetoliposomes for Colon Cancer Therapy Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-23 Ana Cepero, Mónica Jiménez-Carretero, Ylenia Jabalera, Lidia Gago, Cristina Luque, Laura Cabeza, Consolación Melguizo, Concepcion Jimenez-Lopez, José Prados
Purpose: The lack of specificity of conventional chemotherapy is one of the main difficulties to be solved in cancer therapy. Biomimetic magnetoliposomes are successful chemotherapy controlled-release systems, hyperthermia, and active targeting agents by functionalization of their surface with monoclonal antibodies. The membrane receptor Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5)
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Localized Administration of Bcar3 siRNA via Nano-Self-Assembly to Treat Idiopathic Pulmonary Fibrosis by Disrupting Macrophage-Fibroblast Crosstalk Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-23 Chenxi Zeng, Qi Wang, Xuhan Liu, Kai Wang, Congjian Wang, Xuetao Ju, Tianlai Wang, Qing Zhou, Xiangning Fu, Jun Yu, Yi Wang
Background: Idiopathic pulmonary fibrosis (IPF) is a severe interstitial lung disease characterized by chronic lung injury leading to macrophage infiltration and fibroblast activation. However, there is no effective therapeutic strategy targeting the crucial crosstalk between macrophages and fibroblasts to halt IPF progression. Methods: Studies were conducted in IPF patients and fibrotic mice models
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Combined Photosensitive Gene Therapy Effective Against Triple-Negative Breast Cancer in Mice Model Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-23 Yixue Hu, Dongna Wang, Tianyu Zhang, Meng Lei, Yingnan Luo, Zhimeng Chen, Yuting Li, Dandan Duan, Liefeng Zhang, Yongqiang Zhu
Introduction: Tumor hypoxia and invasion present significant challenges for the efficacy of photodynamic therapy (PDT) in triple-negative breast cancer (TNBC). This study developed a mitochondrial targeting strategy that combined PDT and gene therapy to promote each other and address the challenges. Methods: The positively charged amphiphilic material triphenylphosphine-tocopherol polyethylene glycol
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Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-23 Jain Koo, Chaemin Lim, Kyung Taek Oh
Abstract: Addressing disorders related to the central nervous system (CNS) remains a complex challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry of external substances into the brain tissue. Consequently, finding ways to overcome the limited therapeutic effect imposed by the BBB has become a central goal in advancing delivery systems targeted to the brain.
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Efficient Sequential Co-Delivery Nanosystem for Inhibition of Tumor and Tumor-Associated Fibroblast-Induced Resistance and Metastasis Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-23 Chunhong Li, Zhen Wang, Yifeng Zhang, Yuqing Zhu, Maochang Xu, Hui Lei, Dan Zhang
Purpose: Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer. However, the effect of current treatment strategies by inducing tumor cell apoptosis alone is not satisfactory. The growth, metastasis and treatment sensitivity of tumors can be strongly influenced by cancer-associated fibroblasts (CAFs) in the microenvironment. Effective cancer therapies may need to target not
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Natural Products-Based Inhaled Formulations for Treating Pulmonary Diseases Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-23 Jiangyan Yong, Hongli Shu, Xiao Zhang, Kun Yang, Guining Luo, Lu Yu, Jiaqi Li, Hong Huang
Abstract: Given the unique physiological and pathological characteristics of the lung, the direct, inhalable route is more conducive to pulmonary drug delivery and disease control than traditional systemic drug delivery, significantly circumventing drug loss, off-target effects, systemic and organ toxicity, etc., and is widely regarded as the preferred regimen for pulmonary drug delivery. However,
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Characterization of Nanohybridosomes from Lipids and Spruce Homogenate Containing Extracellular Vesicles Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-22 Vesna Spasovski, Anna Romolo, Urška Zagorc, Vesna Arrigler, Matic Kisovec, Apolonija Bedina Zavec, Matevž Arko, Adrienn Molnár, Gitta Schlosser, Aleš Iglič, Ksenija Kogej, Veronika Kralj-Iglič
Introduction: Lipid nanovesicles associated with bioactive phytochemicals from spruce needle homogenate (here called nano-sized hybridosomes or nanohybridosomes, NSHs) were considered. Methods: We formed NSHs by mixing appropriate amounts of lecithin, glycerol and supernatant of isolation of extracellular vesicles from spruce needle homogenate. We visualized NSHs by light microscopy and cryogenic transmission
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Platelet Membrane Biomimetic Manganese Carbonate Nanoparticles Promote Breast Cancer Stem Cell Clearance for Sensitized Radiotherapy Int. J. Nanomed. (IF 8.0) Pub Date : 2024-02-21 Yi Jiang, Xiaoming Liao, Wei Tang, Chunyu Huang, You Pan, Shipeng Ning
Introduction: The presence of cancer stem cells (CSCs) significantly limits the therapeutic efficacy of radiotherapy (RT). Efficient elimination of potential CSCs is crucial for enhancing the effectiveness of RT. Methods: In this study, we developed a biomimetic hybrid nano-system (PMC) composed of MnCO3 as the inner core and platelet membrane (PM) as the outer shell. By exploiting the specific recognition