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Assessment of progression of pulmonary fibrosis based on metabonomics and analysis of intestinal microbiota Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-03-15 Jia-qi Liu, Hong-bing Zhou, Wan-fu Bai, Jia Wang, Qian Li, Li-ya Fan, Hong Chang, Song-li Shi
The main purpose of this study was to explore the changes of biomarkers in different developmental stages of bleomycin-induced pulmonary fibrosis (PF) in rats via comprehensive pathophysiology, UPL...
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Mikania micrantha silver nanoparticles exhibit anticancer activities against human lung adenocarcinoma via caspase-mediated apoptotic cell death Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-03-11 Fanai Lalsangpuii, Samuel Lalthazuala Rokhum, Fanai Nghakliana, Joseph V. L. Ruatpuia, Lalchhandami Tochhawng, Amit Kumar Trivedi, Ralte Lalfakzuala, Zothan Siama
Green-mediated synthesis of nanoparticles has earned a promising role in the area of nanotechnology due to their biomedical applications. This study describes the synthesis of silver nanoparticles ...
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Nitrogen-doped carbon quantum dots as a novel treatment for black fungal bone infections (Mucormycosis): in vitro and in vivo study Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-02-29 Amany Belal, Atiah H. Almalki, Ahmed A. Farghali, Rehab Mahmoud, R. R. Atta, Abeer Enaiet Allah, Walid Hamdy Hassan, Sangmin Lee, Amna A. Kotp, Doaa Essam, Ahmed H. E. Hassan, Mohammed M. Ghoneim, Fatma I. Abo El-Ela, Abdalla Abdelwahab
Most fungal bone and joint infections (arthritis) are caused by Mucormycosis (Mucor indicus). These infections may be difficult to treat and may lead to chronic bone disorders and disabilities, thu...
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Oxygenation through oral Ox66 in a two-hit rodent model of respiratory distress Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-02-29 Bjorn K. Song, Danuel A. Carr, Erica D. Bruce, William H. Nugent
Acute respiratory distress syndrome (ARDS) is a complication of pulmonary disease that produces life-threatening hypoxaemia. Despite ventilation and hyperoxic therapies, undetected hypoxia can mani...
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Comprehensive analysis of anoikis-related genes in diagnosis osteoarthritis: based on machine learning and single-cell RNA sequencing data Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-02-29 Jun-Song Zhang, Run-Sang Pan, Guo-Lu Li, Jian-Xiang Teng, Hong-Bo Zhao, Chang-Hua Zhou, Ji-Sheng Zhu, Hao Zheng, Xiao-Bin Tian
Osteoarthritis (OA) is a degenerative disease closely associated with Anoikis. The objective of this work was to discover novel transcriptome-based anoikis-related biomarkers and pathways for OA pr...
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Harvesting decellularized liver extracellular matrix from rodents for 3D scaffold fabrication Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-02-29 Meghana Kasturi, Kirthanashri S. Vasanthan
Decellularization is a process to harvest the decellularized extra cellular matrix (dECM) that helps develop 3D scaffolds which mimic the native tissue composition. The decellularized tissues retai...
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The identification of metabolites from gut microbiota in coronary heart disease via network pharmacology Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-02-27 Hao-Ming Zhou, Xin-Yu Yang, Shi-Jun Yue, Wen-Xiao Wang, Qiao Zhang, Ding-Qiao Xu, Jia-Jia Li, Yu-Ping Tang
Although the gut microbial metabolites exhibit potential effects on coronary heart disease (CHD), the underlying mechanism remains unclear. In this study, the active gut microbial metabolites actin...
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Correction Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-02-23
Published in Artificial Cells, Nanomedicine, and Biotechnology: An International Journal (Vol. 52, No. 1, 2024)
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A bioconvergence study on platinum-free concurrent chemoradiotherapy for the treatment of HPV-negative head and neck carcinoma Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-02-05 Alessandra Gonnelli, Patrizia Sarogni, Noemi Giannini, Stefania Linsalata, Fabio Di Martino, Agata Zamborlin, Valentina Frusca, Maria Laura Ermini, Paola Puccini, Valerio Voliani, Fabiola Paiar
Locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is characterized by high rate of recurrence, resulting in a poor survival. Standard treatments are associated with significant toxi...
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Studying the effects of secondary metabolites isolated from Cycas thouarsii R.Br. leaves on MDA-MB-231 breast cancer cells Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-01-27 Badriyah Alotaibi, Thanaa A. El-Masry, Engy Elekhnawy, Fatma A. Mokhtar, Hosam M. El-Seadawy, Walaa A. Negm
The various therapeutic drugs that are currently utilized for the management of cancer, especially breast cancer, are greatly challenged by the augmented resistance that is either acquired or de no...
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Advances in nanotechnology-assisted photodynamic therapy for neurological disorders: a comprehensive review Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-01-18 Abdul Nasir, Mujeeb Ur Rehman, Tamreez Khan, Mansoor Husn, Manzar Khan, Ahmad Khan, Abdifatah Mohamed Nuh, Wei Jiang, Hafiz Muhammad Umer Farooqi, Qain Bai
Neurological disorders such as neurodegenerative diseases and nervous system tumours affect more than one billion people throughout the globe. The physiological sensitivity of the nervous tissue li...
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Investigation of pharmacokinetics and immunogenicity of magnetosomes Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-01-12 M. Haripriyaa, K. Suthindhiran
Magnetosomes are iron oxide or iron sulphide nano-sized particles surrounded by a lipid bilayer synthesised by a group of bacteria known as magnetotactic bacteria (MTB). Magnetosomes have become a ...
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Preparation of titanium dioxide nanoparticles from Solanum Tuberosum peel extract and its applications Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2024-01-12 Agnishwar Girigoswami, Balasubramanian Deepika, Ashok Kumar Pandurangan, Koyeli Girigoswami
The present study describes a method for the preparation of green titanium dioxide (TiO2) nanoparticles from the peel of Solanum tuberosum, commonly known as potato, and the potato peel being a kit...
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Synthesis and characterization of Fe3O4@SiO2@PDA@Ag core–shell nanoparticles and biological application on human lung cancer cell line and antibacterial strains Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-12-29 Snigdha Singh, Tanya Goel, Aarushi Singh, Heerak Chugh, Nayanika Chakraborty, Indrajit Roy, Manisha Tiwari, Ramesh Chandra
Novel magnetic and metallic nanoparticles garner much attention of researchers due to their biological, chemical and catalytic properties in many chemical reactions. In this study, we have successf...
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Haemostatic potency of sodium alginate/aloe vera/sericin composite scaffolds – preparation, characterisation, and evaluation Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-12-19 Jayavardhini Bhoopathy, Weslen Vedakumari Sathyaraj, Beryl Vedha Yesudhason, Selvarajan Rajendran, Sankari Dharmalingam, Jayashri Seetharaman, Ranjitha Muthu, Ramachandran Murugesan, Subramanian Raghunandhakumar, Suresh Kumar Anandasadagopan
Fabrication of haemostatic materials with excellent antimicrobial, biocompatible and biodegradable properties remains as a major challenge in the field of medicine. Haemostatic agents play vital ro...
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Inhibitory effects of Curcumae Radix carbonisata-based carbon dots against liver fibrosis induced by carbon tetrachloride in mice Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-11-30 Yusheng Zhao, Hui Kong, Yuru Li, Yafang Zhao, Yue Zhang, Yan Zhao, Huihua Qu
As a processed product of traditional Chinese medicine Curcumae Radix, Curcumae Radix Carbonisata (CRC) has been widely used in the treatment of liver diseases in ancient medical books. In this stu...
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HBOC alleviated tumour hypoxia during radiotherapy more intensely in large solid tumours than regular ones Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-11-23 Yingcan Xu, Kehui Zhu, Jiakang Wu, Shifan Zheng, Rui Zhong, Wentao Zhou, Ye Cao, Jiaxin Liu, Hong Wang
Radiotherapy (RT) is a highly valuable method in cancer therapy, but its therapeutic efficacy is limited by its side effects and tumour radiation resistance. The resistance is mainly induced by hyp...
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Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-11-23 Yumin Chen, Xue Bai, Ying Zhang, Yafang Zhao, Huagen Ma, Yunbo Yang, Meijun Wang, Yinghui Guo, Xiaopeng Li, Tong Wu, Yue Zhang, Hui Kong, Yan Zhao, Huaihua Qu
Chinese herbs contain substances that regulate female hormones. Our study confirmed that Zingiberis rhizoma carbonisata contains Zingiberis rhizoma-based carbon dots (ZR-CDs), which exert regulator...
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Advances in screening and diagnostic lab-on-chip tools for gynaecological cancers – a review Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-11-07 Sadeka Nujhat, Hannah S. Leese, Mirella Di Lorenzo, Rebecca Bowen, Sandhya Moise
Gynaecological cancers are a major global health concern due to the lack of effective screening programmes for ovarian and endometrial cancer, for example, and variable access to vaccination and sc...
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Process-structure-biofunctional paradigm in cellular structured implants: an overview and perspective on the synergy between additive manufacturing, bio-mechanical behaviour and biological functions Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-11-07 R. D. K. Misra, K. P. Misra
The overview describes the synergy between biological sciences and cellular structures processed by additive manufacturing to elucidate the significance of cellular structured implants in eliminati...
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Niosomes gel of apigenin to improve the topical delivery: development, optimization, ex vivo permeation, antioxidant study, and in vivo evaluation Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-11-01 Omar Awad Alsaidan, Ameeduzzafar Zafar, Rayan Hamood Al-Ruwaili, Mohd Yasir, Sami I. Alzarea, Aseel Awad Alsaidan, Lubhan Singh, Mohammad Khalid
Niosomes (NS) are the promising and novel carrier of the drug for effective transdermal delivery. Apigenin (AN) is a natural bioactive compound and has various pharmacological activities. AN is poo...
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A study on the therapeutic potential of graphene titanate nanocomposite for treating chemically induced arthritis in rats Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-10-30 Amany Belal, Mohamed Y. Zaky, Doaa S. Mohamed, Eman E. Mohamed, Rehab Mahmoud, Doaa Essam, R. R. Atta, Fatma I. Abo El-Ela, Fatma Mohamed Halfaya, Kyung-Tae Lee, Ahmed H.E Hassan, Mohammed M. Ghoneim, Ahmed Farghali
Nanotechnology holds substantial promise in the innovative therapies for rheumatoid arthritis (RA). The current study was designed to synthesize and characterize a new graphene titanate nanocomposi...
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Cancer reduction in mice with Prakasine nanomedicine immunotherapy Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-10-26 Prakash S.K
In this study, non-toxic mercury nanoparticle Prakasine (PRK-NP) was synthesized as per ‘Prakash theory of metal drugs’ and nanoparticle’s non toxicity has been demonstrated by employing in vitro M...
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Statement of retraction: Mirt2 functions in synergy with miR-377 to participate in inflammatory pathophysiology of Sjögren’s syndrome Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-10-23
Published in Artificial Cells, Nanomedicine, and Biotechnology: An International Journal (Vol. 51, No. 1, 2023)
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Statement of retraction: Anti-gastric cancer effect of Salidroside through elevating miR-99a expression Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-10-23
Published in Artificial Cells, Nanomedicine, and Biotechnology: An International Journal (Vol. 51, No. 1, 2023)
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Ultrasound-triggered release of miR-199a-3p from liposome nanobubbles for enhanced hepatocellular carcinoma treatment Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-10-18 Xinmin Guo, Jianru Lin, Liwen Pan, Kun He, Zhihui Huang, Jialin Chen, Cuiyan Lin, Baohui Zeng, Sijia Luo, Mengdie Wang
This study was aimed to develop an efficient tumour-targeted liposome nanobubbles (LNBs) system using ultrasound-targeted nanobubble destruction for enhanced release and transfection of miRNA-199a-...
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Green synthesis, characterisation and antibacterial activities of Strobilanthes crispus-mediated silver nanoparticles (SC-AGNPS) against selected bacteria Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-10-17 Rohazila Mohamad Hanafiah, Siti Aisyah Abd Ghafar, Vuanghao Lim, Siti Nor Asma Musa, Fahmi Yakop, Arif Haikal Hairil Anuar
This study aims to characterize and determine the antibacterial activities of synthesized Strobilanthes crispus-mediated AgNPs (SC-AgNPs) against Streptococcus mutans, Escherichia coli and Pseudomo...
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Study on tumour cell-derived hybrid exosomes as dasatinib nanocarriers for pancreatic cancer therapy Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-10-05 Xiaofei Zhou, Yuetang Zhuang, Xiaohong Liu, Yaowen Gu, Junting Wang, Yuchen Shi, Li Zhang, Rui Li, Yelin Zhao, Hebing Chen, Jiao Li, Hongjuan Yao, Liang Li
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death. Therefore, we intend to explore novel strategies against PDAC. The exosomes-based biomimetic nanopartic...
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Correction Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-09-22
Published in Artificial Cells, Nanomedicine, and Biotechnology: An International Journal (Vol. 51, No. 1, 2023)
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Molecular complexity of mammary glands development: a review of lactogenic differentiation in epithelial cells Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-09-11 Manoj Kumar Jena, Farheen Badrealam Khan, Syed Azmal Ali, Abdullah Abdullah, Amarish Kumar Sharma, Vikas Yadav, Sudhakar Kancharla, Prachetha Kolli, Gowtham Mandadapu, Anjan Kumar Sahoo, Prasana Kumar Rath, Jalal Taneera, Sudarshan Kumar, Ashok Kumar Mohanty, Khang Wen Goh, Long Chiau Ming, Chrismawan Ardianto
Abstract The mammary gland is a dynamic organ with various physiological processes like cellular proliferation, differentiation, and apoptosis during the pregnancy-lactation-involution cycle. It is essential to understand the molecular changes during the lactogenic differentiation of mammary epithelial cells (MECs, the milk-synthesizing cells). The MECs are organized as luminal milk-secreting cells
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Molecular docking and physicochemical studies of 1,3-benzodioxole tagged Dacarbazine derivatives as an anticancer agent Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-09-12 Sonaxi Kharb, Sangeeta Yadav, Anshul Singh, Anjana Sarkar, Ravi Tomar
Abstract Cancer, the biggest cause of death globally, remains a tough illness despite enormous advances in therapy. In the present study, 1,3-benzodioxole-tagged dacarbazine derivates were investigated as microtubule inhibitors in order to control cancer as microtubules are involved in cell proliferation. The tubulin protein was analyzed and its structure was validated by various protein validation
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Identification and characterization of shark VNARs targeting the Helicobacter pylori adhesin HpaA Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-09-11 Yanchun Gao, Ruihong Wang, Lin Liu, Shitao Feng, Xiaozhi Xi, Wengong Yu, Yuchao Gu, Ye Wang
Abstract Helicobacter pylori (H. pylori) is recognized as a pathogen associated with several gastrointestinal diseases. The current treatments exhibit numerous drawbacks, including antibiotic resistance. H. pylori can adhere to and colonize the gastric mucosa through H. pylori adhesin A (HpaA), and antibodies against HpaA may be an effective therapeutic approach. The variable domain of immunoglobulin
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Dissecting the tumour immune microenvironment in merkel cell carcinoma based on a machine learning framework Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-09-07 Shaowen Cheng, Si Li, Ping Yang, Rong Wang, Ping Zhou, Jingquan Li
Abstract Merkel cell carcinoma (MCC) is a primary cutaneous neoplasm of neuroendocrine carcinoma of the skin, which is characterized by molecular heterogeneity with diverse tumour microenvironment (TME). However, we are still lack knowledge of the cellular states and ecosystems in MCC. Here, we systematically identified and characterized the landscape of cellular states and ecotypes in MCC based on
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Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-09-04 E. Fernandez-Carro, R. Salomon-Cambero, L. Armero, H. A. Castro-Abril, J. Ayensa-Jiménez, Miguel A. Martínez, I. Ochoa, C. Alcaine, I. García, J. Ciriza
Abstract Tissue barrier permeability plays a crucial role in determining the selective transport of substances across epithelial tissues, including drugs, cosmetic substances, and chemicals. The ability of these substances to cross through tissue barriers affects their absorption into the bloodstream and ultimately their effectiveness. Therefore, the determination of their permeability on these type
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Advancement in biomarker based effective diagnosis of neonatal sepsis Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-09-01 Neha Gopal, Nidhi Chauhan, Utkarsh Jain, Sujata K. Dass, Hari S. Sharma, Ramesh Chandra
Abstract Neonatal sepsis is considered as alarming medical emergency and becomes the common global reason of neonatal mortality. Non-specific symptoms and limitations of conventional diagnostic methods for neonatal sepsis mandate fast and reliable method to diagnose disease for point of care application. Recently, disease specific biomarkers have gained interest for rapid diagnosis that led to the
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Systematical analyses of large-scale transcriptome reveal viral infection-related genes and disease comorbidities Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-08-31 Jing Guo, Ya Zhang, Yueying Gao, Si Li, Gang Xu, Zhanyu Tian, Qi Xu, Xia Li, Yongsheng Li, Yunpeng Zhang
Abstract Perturbation of transcriptome in viral infection patients is a recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent transcriptome and identification of robust biomarkers is not complete. In this study, we manually collected 23 datasets related to 6,197 blood transcriptomes across 16 types of respiratory virus infections. We applied a comprehensive systems
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Construction of silver-coated high translucent zirconia implanting abutment material and its property of antibacterial Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-08-18 Min Peng, Jun-Lan Chuan, Gao-ping Zhao, Qiang Fu
Abstract High translucent zirconia (HTZ) has excellent mechanical properties, biocompatibility, and good semi-translucency making it an ideal material for aesthetic anterior dental implant abutments without antibacterial properties. In the oral environment, the surface of the abutment material is susceptible to microbial adhesion and biofilm formation, which can lead to infection or peri-implantitis
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Liposomes for drug delivery: review of vesicular composition, factors affecting drug release and drug loading in liposomes Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-08-18 Shantanu Pande
Abstract Liposomes are considered among the most versatile and advanced nanoparticle delivery systems used to target drugs to specific cells and tissues. Structurally, liposomes are sphere-like vesicles of phospholipid molecules that are surrounded by equal number of aqueous compartments. The spherical shell encapsulates an aqueous interior which contains substances such as peptides and proteins, hormones
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Anticancer potentials of metformin loaded coconut oil nanoemulsion on MCF-7, HepG2 and HCT-116 cell lines Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-08-17 Hadil Faris Alotaibi, El-Sayed Khafagy, Amr Selim Abu Lila, Haifa F. Alotaibe, Serag Eldin Elbehairi, Ashwag S. Alanazi, Mohammad Y. Alfaifi, Jawaher Abdullah Alamoudi, Sarah Salem Alamrani, Fatma Alzahraa Mokhtar
Abstract In order to load metformin in a nano formula and evaluate the produced nano form towards cancer cells, metformin was loaded on natural carrier coconut oil. The formed metformin-loaded coconut oil nanoemulsion was characterized by Zeta potential, particle size, drug content, drug release, and drug stability. The formed nanoemulsion was evaluated towards MCF-7, HepG2, and HCT-116 cell lines
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Generation of a novel ex-vivo model to study re-endothelialization Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-08-16 Siti Sarah Azman, Muhammad Dain Yazid, Nur Azurah Abdul Ghani, Raja Zahratul Azma Raja Sabudin, Mohd Ramzisham Abdul Rahman, Nadiah Sulaiman
Abstract Endothelial dysfunction initiates the pathogenesis of a myriad of cardiovascular diseases, yet the precise underlying mechanisms remain unclear. Current model utilises mechanical denudation of arteries resulting in an arterial-injury model with onset of intimal hyperplasia (IH). Our study shows that 5 min enzymatic denudation of human umbilical artery (hUA) lumen at 37 °C efficiently denudes
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Correction Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-08-14
Published in Artificial Cells, Nanomedicine, and Biotechnology: An International Journal (Vol. 51, No. 1, 2023)
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An impedance flow cytometry with integrated dual microneedle for electrical properties characterization of single cell Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-08-07 Muhammad Asraf Mansor, Mohd Ridzuan Ahmad, Michal Petrů, Seyed Saeid Rahimian Koloor
Abstract Electrical characteristics of living cells have been proven to reveal important details about their internal structure, charge distribution and composition changes in the cell membrane, as well as the extracellular context. An impedance flow cytometry is a common approach to determine the electrical properties of a cell, having the advantage of label-free and high throughput. However, the
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IgG antibodies mediated gold nanoparticles conjugated to methotrexate as targeted chemotherapy for lung cancer Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-08-07 Asad Syed, Abu Baker, Mohamed Mohany, Abdallah M. Elgorban, Mohd Sajid Khan, Salim S. Al-Rejaie
Abstract Vincamine, a natural chemical, was used as a reducing agent in the synthesis of IgG antibodies mediated biogenic gold nanoparticles (IgGAuNPs). Eventually, the synthesised IgGAuNPs were bioconjugated with the chemotherapeutic drug methotrexate (MTX-IgGAuNPs). The IgG isotype can target cancer cells through polymorphic Fc gamma receptors (FcγRs) and have therapeutic effects. They can restrict
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Cholesterol-linoleic acid liposomes induced extracellular vesicles secretion from immortalized adipose-derived mesenchymal stem cells for in vitro cell migration Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-07-31 Jzit Weii Chen, Fong Fong Liew, Hsiao Wei Tan, Misni Misran, Ivy Chung
Abstract Extracellular vesicles (EVs) are small vesicles that are naturally released by cells and play a crucial role in cell-to-cell communication, tissue repair and regeneration. As naturally secreted EVs are limited, liposomes with different physicochemical properties, such as 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and linoleic acid (LA) with modifications have been formulated to improve
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Novel curcumin nanoformulation induces apoptosis, and reduces migration and angiogenesis in liver cancer cells Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-07-31 Steve Harakeh, Saber H. Saber, Rajaa Al-Raddadi, Turki Alamri, Soad Al-Jaouni, Mohammed Qari, Yousef Qari, Shafiul Haque, Ayat Zawawi, Soad S. Ali, Zakaria Y. Abd Elmageed, Shaker Mousa
Abstract Background Curcumin has been used in the treatment of several diseases; however, its low pharmacologic profile reduces its therapeutic use. Towards improving its biological activity, nanoformulations have emerged. Thus, we aimed to determine whether curcumin nanoparticles (Cur-NPs) coated with PEG/chitosan improve the treatment of liver cancer (LC) cells and underpin the molecular mechanisms
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Impact of Aluminium phthalocyanine nanoconjugate on melanoma stem cells Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-07-16 Bridgette Mkhobongo, Rahul Chandran, Heidi Abrahamse
Abstract Metastatic melanoma cancer stem cells are subpopulations linked to tumour development, immunoevasive behaviour, treatment resistance, and metastasis, all of which contribute to a poor prognosis. Photodynamic treatment (PDT) is an alternate strategy to cancer eradication that involves the generation of reactive oxygen species. As a carrier, nanoparticles enable efficient cellular uptake of
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Green synthesis of ZnO-NPs using endophytic fungal extract of Xylaria arbuscula from Blumea axillaris and its biological applications Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-07-11 Lavanya Nehru, Gayathri Devi Kandasamy, Vanaraj Sekar, Mohammed Ali Alshehri, Chellasamy Panneerselvam, Abdulrahman Alasmari, Preethi Kathirvel
Abstract The biogenic manufacture of nanoparticles utilising endophytic fungus is an eco-friendly, cost-effective, and secure alternative to constructing chemical methods. The prime focus of the study was to fabricate ZnONPs using the biomass filtrate of endophytic Xylaria arbuscula isolated from Blumea axillaris Linn. and to evaluate their biological properties. The characterisation of the biosynthesized
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Facile biosynthesis, characterisation and biotechnological application of ZnO nanoparticles mediated by leaves of Cnidoscolus aconitifolius Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-06-10 Reuben Samson Dangana, Reama Chinedu George, Umulkhayr Oyenike Shittu, Femi Kayode Agboola
Abstract The present study synthesised and characterised zinc oxide nanoparticles (ZnO NPs) using spinach tree, Cnidoscolus aconitifolius and investigated its potential use as nanofertilizer. The synthesised nanoparticles showed UV–Vis absorption peak at 378 nm which is a feature of ZnO NPs. FT-IR analysis further revealed the presence of O-H stretching, C = C bending, O-H bending and C-N stretching
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Preparation and exchange transfusion effect of a double polymerization human umbilical cord haemoglobin of red blood cell substitute Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-05-24 Wentao Zhou, Shen Li, Shasha Hao, Xintong Xie, Honghui Zhang, Jiaxin Liu, Hong Wang, Chengmin Yang
Abstract The development of haemoglobin-based oxygen carrier (HBOC) is an excellent supplement to pre-hospital emergency blood transfusions. In this study, a new type of HBOC was prepared by using human cord haemoglobin (HCHb) and glutaraldehyde (GDA) and Bis(3,5-dibromosalicyl) fumarate (DBBF) to modify (DBBF-GDA-HCHb), the changes of physicochemical indexes during its preparation were evaluated,
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Antibacterial and anti-Toxoplasma activities of Aspergillus niger endophytic fungus isolated from Ficus retusa: in vitro and in vivo approach Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-05-24 Ehssan Moglad, Engy Elekhnawy, Walaa A. Negm, Duaa Eliwa, Salwa Sami Younis, Basma Mohamed Elmansory, Sebaey Mahgoub, Eman A. Ahmed, Omnia Momtaz Al-Fakhrany
Abstract Emergent records propose that Aspergillus niger endophytic fungus is a vital source for various bioactive molecules possessing many biological properties. The current study was designed to inspect the antibacterial and anti-Toxoplasma potentials of Ficus retusa-derived endophytic fungi. After isolation and identification (using 18S rRNA gene sequencing) of A. niger endophytic fungus, LC/MS
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Identification and verification of pivotal genes promoting the progression of atherosclerosis based on WGCNA Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-05-23 Jing Wen, Tong Ren, Jinzhen Zheng, Xing Jiang, Yingxia Li, Xilin Jiang, Xin Jin, Hongying Zhao, Jingwen Li
Abstract As the main pathological basis for the development of cardiovascular and cerebrovascular diseases, atherosclerosis (AS) seriously affects human health. The key targets of biological information analysis of AS can help exploit therapeutic targets. The expression data of early and progressive atherosclerotic tissues were downloaded from the Gene Expression Omnibus (GEO) database. Based on GSE28829
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Therapeutic ultrasound treatment for the prevention of chronic kidney disease-associated muscle wasting in mice Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-05-17 Chen-Yu Lin, Te-I Weng, Jui-Zhi Loh, Ding-Cheng Chan, Chih-Kang Chiang, Kuan-Yu Hung, Shing-Hwa Liu
Abstract Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound. It can help improve bone fracture repair and soft tissue healing. Our previous study found that LIPUS treatment could halt the chronic kidney disease (CKD) progression in mice; unexpectedly, we observed the improvement of CKD-reduced muscle weights by LIPUS treatment. Here, we further tested the protective potential
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Statement of Retraction Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-05-10
Published in Artificial Cells, Nanomedicine, and Biotechnology: An International Journal (Vol. 51, No. 1, 2023)
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Antiviral and antibacterial potential of electrosprayed PVA/PLGA nanoparticles loaded with chlorogenic acid for the management of coronavirus and Pseudomonas aeruginosa lung infection Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-05-08 Asmaa Saleh, Dalia H. Abdelkader, Thanaa A. El-Masry, Duaa Eliwa, Badriyah Alotaibi, Walaa A. Negm, Engy Elekhnawy
Abstract Respiratory tract infections are a common cause of morbidity and mortality globally. The current paper aims to treat this respiratory disorder. Therefore, we elucidated the phytochemical profile of Euphorbia milii flowers and isolated chlorogenic acid (CGA) for the first time. The electrospraying technique was utilized to prepare CGA nanoparticles in polyvinyl alcohol (PVA)/PLGA polymeric
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Exploration of effective biomarkers and infiltrating Immune cells in Osteoarthritis based on bioinformatics analysis Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-05-04 Piaotao Cheng, Shouhang Gong, Caopei Guo, Ping Kong, Chencheng Li, Chengbing Yang, Tao Zhang, Jiachen Peng
Abstract Osteoarthritis (OA) is a multi-factorial chronic joint disease mainly identified by synovial inflammation, cartilage damage, and degeneration. Our study applied bioinformatics analysis to uncover the immunity in OA and tried to explore the underlying immune-related molecular mechanism. First, OA-related gene-expression profiling data were retrieved from GEO database. Then, we analysed a series
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Simple and feasible detection of hepatitis a virus using reverse transcription multienzyme isothermal rapid amplification and lateral flow dipsticks without standard PCR laboratory Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-04-27 Mao-ling Sun, Yang Zhong, Xiao-na Li, Jun Yao, Yu-qing Pan
Abstract Hepatitis A virus (HAV) is mainly transmitted via contaminated food and water. HAV infection is a major global public health problem. Thus, developing a simple, rapid detection method is crucial for containing HAV epidemics, particularly in developing regions with limited laboratory resources. This study established a feasible HAV detection solution by combining reverse transcription multienzyme
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The seamless integration of dietary plant-derived natural flavonoids and gut microbiota may ameliorate non-alcoholic fatty liver disease: a network pharmacology analysis Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-04-27 Ki-Kwang Oh, Haripriya Gupta, Raja Ganesan, Satya Priya Sharma, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Min-Kyo Jeong, Byeong-Hyun Min, Ji-Ye Hyun, Jung-A Eom, Hee-Jin Park, Sang-Jun Yoon, Mi-Ran Choi, Dong Joon Kim, Ki-Tae Suk
Abstract We comprised metabolites of gut microbiota (GM; endogenous species) and dietary plant-derived natural flavonoids (DPDNFs; exogenous species) were known as potent effectors against non-alcoholic fatty liver disease (NAFLD) via network pharmacology (NP). The crucial targets against NAFLD were identified via GM and DPDNFs. The protein interaction (PPI), bubble chart and networks of GM or natural
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Design and assembly of a nanoparticle, antibody, phthalocyanine scaffold for intracellular delivery of photosensitizer to human papillomavirus-transformed cancer cells Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-04-21 Elvin Peter Chizenga, Heidi Abrahamse
Abstract In photodynamic therapy (PDT), internalization and uptake of the photosensitizer (PS) by the cells is a passive process that relies on the enhanced permeability and retention (EPR) effect of tumour tissues due to their vasculature, increased LDL receptors, and decreased lymphatic drainage in vivo. But as worries about PDT resistance grow, using passive techniques to administer PSs is becoming
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The Rhei radix rhizoma-based carbon dots ameliorates dextran sodium sulphate-induced ulcerative colitis in mice Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-04-18 Yifan Zhang, Jie Zhao, Yusheng Zhao, Xue Bai, Yumin Chen, Yuhan Liu, Yue Zhang, Hui Kong, Huihua Qu, Yan Zhao
Abstract As an autoimmune disease of the colon, the incidence of ulcerative colitis (UC) remains high. Carbon dots (CDs), a new type of nanomaterials, display excellent biological activity and are expected to inspire a new treatment for UC. A green method was used to carbonise rhei radix rhizoma (RRR) and extract CDs to study their anti-ulcer activity. The RRR-based carbon dots (RRR-CDs) were characterised
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Encapsulation of propolis extracts in aqueous formulations by using nanovesicles of lipid and poly(styrene-alt-maleic acid) Artif. Cells Nanomed. Biotechnol. (IF 5.8) Pub Date : 2023-04-13 Chatmani Buachi, Charothar Thammachai, Brian J. Tighe, Paul D. Topham, Robert Molloy, Patchara Punyamoonwongsa
Abstract Bee propolis has been used in alternative medicine to treat various diseases. Due to its limited water solubility, it is often used in combination with alcohol solvents, causing skin irritation and immune response. To solve this, the new drug delivery system, based on the lipid nanodiscs of 1,2-dimyristoyl-sn-glycero-3-phosphochline (DMPC) and poly(styrene-alt-maleic acid) (PSMA), were created