As an immediate priority, finding a solution for the new coronavirus (SARS-CoV-2) pandemic is on the agenda of scientists of the world. Herein, we summarize all the suggested global solutions proposed by scientists and physicians so far to stop this dangerous virus. Also, the important molecular targets for hitting the killer virus are highlighted.

Abstract In this study, we decided to synthesize some new chalcone-type dyes derived from dehydroacetic acid (DHA) by the condensation of 4-amino-substituted benzaldehyde with DHA under the base-catalyzed condition and investigate their ability for rearrangement in acidic condition. For this purpose, initially we prepared the 4-aminobenzaldehyde derivatives via nucleophilic aromatic substitution reaction

Albumin nanoparticles are considerable in nanotechnology due to their high solubility in aqueous media, their ability to interact with various compounds, and their ease of nanoparticle tailoring from them. Due to the undesirable effects of glutaraldehyde (GT) as a cross-linker, the aim of this study was to investigate different cross-linking agents such as tannic acid, ascorbic acid, citric acid, sorbitol

In the present study, parameters affecting the particle size and drug loading of curcumin-loaded hydroxyapatite–polyvinyl alcohol (HAp-PVA) nanocomposites were investigated and optimized. The nanocomposites were synthesized by using chemical precipitation technique, and curcumin was subsequently incorporated into the prepared nanocomposites through an impregnation methodology. Dynamic light scattering

This study presents the discoloration of methylene blue by heterogenous Fenton-like process using copper. Copper was prepared with sodium ascorbate, an eco-friendly reagent under atmospheric conditions and characterized using X-ray diffraction and scanning electron microscope analysis. Sub-micron-sized particles were formed and mainly composed of metallic copper Cu with the minor presence of Cu2O.

In the present study, degradation of Reactive Orange 7 dye was investigated using a new designed titanium electrode, in which a plate of Ti was coated with multi-walled carbon nanotubes (Ti/MWCNT) via electrophoretic deposition technique. A series of characterizations including field scanning electron microscopy, X-ray diffraction, cyclic voltammetry, scanning electrochemical impedance spectroscopy

Synthesis of novel α-aminophosphonate hybrids 8a–f was accomplished by the reaction of 11-phenoxy-4-formylneocryptolepine 3, aminoalkylamino acridines 6a–f and diphenyl phosphite 7 in the presence of lithium perchlorate as Lewis acid catalyst in methanol. The starting aldehyde 3 was obtained by reaction of 11-chloroneocryptolpine 1 with 4-hydroxybenzaldehyde 2 in the presence of potassium carbonate

In biological research, increasing the effectiveness of anticancer drugs and attenuating multidrug resistance are of prime importance. In this study, a combination of docking–quantitative structure activity relationship (QSAR) method is implemented for modeling and predicting inhibition activity (pIC50) of CINPA1 analogs as the constitutive androstane receptor (CAR) inverse agonists. Docking studies

Molybdenum-exchanged ZSM-5 catalysts were tested in ethane ammoxidation into acetonitrile at 500 °C and at a very low contact time (0.08 s). The solids were prepared by sublimation, impregnation in CCl4 and solid-state ion exchange methods. The hydration state of the zeolite strongly affected the nature of MoCl5 and Mo(CO)6 decomposition products and, therefore, the concentration of stabilized Mo species

Interfacial tension (IFT) plays an important role in the processes like extraction and emulsification, and that low level IFT is usually preferred for better hydrodynamic performance of unit operations. The present study explores the effect of a saponin-rich extract from Glycyrrhiza glabra plant on the IFT of conventional n-hexane/water system. FTIR, HPLC and LC/MS analysis indicates a 31.39% glycyrrhizic

A dual responsive sensor molecule, 2-(4-(2,2′:6′,2″-terpyridin)-4′-yl-phenyl)-N-methyl-3-thiosemicarbazone, has been synthesized and characterized using standard analytical and spectroscopic techniques. The dual binding properties of the sensor molecule were investigated using biologically important inorganic cations (Mn2+, Fe2+, Ni2+, Cu2+, Zn2+, Pb2+ and Hg2+) and anions (F¯, Cl¯, Br¯, I¯, HSO4¯

Wastewater treatment for lowering down the amount of antibiotic drugs in environment is essential for preventing their harmful effects in the ecosystem and for diminishing the growing bacterial resistance. Here, gold-decorated Fe3O4 nanoparticles (NPs) were used for efficient photocatalytic degradation of ampicillin, investigated by UV/Vis absorbance spectrometry. The absorbance data matrices recorded

In our QSAR study, pharmacophore identification and biological activity estimation of 80 methanone derivatives were performed with the Electron Conformation Genetic Algorithm approach. Using the geometric, thermodynamic and topological properties of molecules from the data obtained from quantum chemical calculations in the HF/3-21 G basis set, the Electron Conformational Matrices of Congruity were

One-step anodization combined with chemical bath deposition was used to prepare ternary hybrid SnO2@WO3–TiO2 photoelectrodes. Various analytical techniques such as X-ray diffraction, field emission scanning electron microscopy, energy-dispersive spectrometry and ultraviolet visible spectroscopy were applied to characterize the synthetic hybrids. Photoelectrochemical water splitting performance of new

Abstract In this work by controlling the interaction between the inorganic complexes and the support material, we have designed a high-activity nanostructured combined of magnetic nanoparticles and Pd–ninhydrin-terminated complex as catalyst. The as-prepared catalyst was characterized by FT-IR, XRD, VSM, SEM, EDAX, ICP, and TGA techniques. This magnetic nanostructure can be used as a novel, green,

This article proposed the theoretical model of Arrhenius equation of differential equation with the density functional theory (DFT) to realize the structural and electronic characteristics by converting chalcone 1 to azacoumarin 4 via 2-pyridone derivatives 2. Ultrasonic velocity, density and percentage deviation in concentration were measured by 7-aryl-5-arylidenyl-8-azacoumarin ester 4, 3-cyano derivative

In this study, we focused on the interference of methylparaben (MP), as the most commonly used paraben, on hemoglobin (Hb) fructation, generating reactive oxygen species (ROS) and resulting lipid peroxidation (LPO). We showed the enhancement of ROS generation and heme degradation during hemoglobin fructation in the presence of MP using some biophysical techniques such as chemiluminescence and fluorescence

Molecularly imprinted polymers (MIPs) are polymers possessing receptor cavities with selective characteristics. The molecularly imprinted polymer of 1,8-cineole on hydroxyl-functionalized multiwall carbon nanotubes was synthesized for selective extraction of 1,8-cineole in water distillates of Artemisia sieberi (sagebrush) and thyme samples. The MIP was synthesized with cineole as template, methacrylic

Abstract An expeditious metal-free heteroannulation reaction for pyrido[1,2-a]pyrimidines/imidazo[1,2-a]pyridines was developed in green solvent under mild reaction conditions by using three-component reaction of 2-chloroquinoline-3-carbaldehyde, malononitrile and nitroketen aminals, which obtained from the reaction between 1,1-bis(methylthio)-2-nitroethylene and diamines in green solvent under EtOH

Two series of new N-aryl/aralkyl derivatives (9a–q) of 2-(4-ethyl-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio)acetamide and N-aryl/aralkyl derivatives (10a–q) of 2-(4-phenyl-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio)acetamide were synthesized. The methods included successive conversions of thiophen-2-acetic acid (a) into its respective ester, hydrazide and N-aryl/aralkyl 1,3,4-triazole

Clorprenaline hydrochloride (CLOR), β2 adrenergic agonist, was used for the therapeutic treatment for bronchial asthma. It is important to know the stability behavior of the drug in various degradation conditions because the drug is incompatible with strong oxidizing agent and strong base. The main objective of the study was to identify and characterize degradation products of clorprenaline HCl by

Abstract Nitrobenzene (NB) is a highly toxic and hazardous compound that needs to be detected at the low level. The current work describes an eco-friendly synthesis of silver nanoparticles (SNPs) using a Eucalyptus extract as reducing and stabilizing agent and its use for electrochemical detection of NB. The synthesized SNPs were characterized by following techniques UV–visible spectroscopy, powder

Abstract Gallic acid (GA) and its benzamide derivatives have a wide variety of biological activities, such as antimicrobial, antioxidant, anticancer. In this study, we have reported the synthesis of some new hybrid compounds comprised of the 2-aminothiophene and GA moieties and evaluation of their cytotoxic activities against HeLa (cervical cancer), HCT116 (human colon cancer), and FT (fibroblast)

Abstract In the current investigation, the electrochemical oxidation of caffeic acid (CA) in the absence and presence of 1,4-benzenediboronic acid (BDA) was studied. The voltammetric study indicates that CA (1) oxidized to its o-benzoquinone (1ox) within a two-electron process. In basic pHs, the electrochemically generated 1ox is unstable and participates in the dimerization reaction. The results indicate

Abstract Graphitic carbon nitride as an interesting sustainable soft nanomaterial has drawn broad interdisciplinary attention because of unique electronic structure and chemical stability. An ultrasound-assisted preparation of a series of polysubstituted pyridines in the presence of a polar and strongly acidic sulfonated magnetic graphitic carbon nitride (Fe3O4@g-C3N4-SO3H) under milder and faster

Abstract A comparative study between in situ screen printed (SPE), carbon paste (CPE) and carbon nanotube modified graphite (CNTME) electrodes was established for the determination of tetra-n-butylammonium bromide (TBAB) in pure and spiked tap water samples. Different experimental conditions as ion-pairing agent type and content, carbon nanotube content, plasticizer, response and soaking time, pH and

Abstract In this study, a green protocol for synthesis of N-arylacetamides was introduced. Magnetically, nanoparticles of the immobilized copper species on nickel ferrite, NiFe2O4@Cu, were synthesized and then characterized using SEM, EDX, XRD, VSM, ICP-OES, BET and XPS analyses. The XPS analysis approved that the immobilized copper species on NiFe2O4 only contain Cu(0) and its oxide form as CuO. The

Abstract Magnetic nano-carbon core shell was applied as mixed hemimicelle magnetic solid phase extraction adsorbent to introduce a novel sample preparation method for determination of acrylamide from potato chips. Acrylamide is identified as neurotoxic, a probable human carcinogen (group 2A) compound. Effective extraction parameters such as type and amount of extracting solvent, type and amount of

Abstract In this paper, a dispersive liquid–liquid microextraction (DLLME) based on the application of in situ ionic liquids (in situ ionic liquid DLLME) was developed for preconcentration and determination of trace amount of phenol and endocrine-disrupting phenols in aqueous samples. The experimental parameters of an in situ ionic liquid DLLME method were investigated and optimised using an orthogonal

Abstract In this work, we report fast and low-cost fluorimetric system for the determination of trace amounts of water in both aprotic and protic organic solvents. The analytical signal of the proposed method is based on the quenching effects of water on the fluorescence emission spectrum of (4, 4′-diamino-4″-methoxytriphenylamine) molecule. It was found that physical interactions such as hydrogen

Abstract The use of the efficient drug delivery systems in combinatorial or multi-drug treatment of complicated diseases for effective and target-specific delivery of therapeutic agents necessitates the use of the fast and reliable analytical techniques to reveal the true release profiles of the investigated drugs. The knowledge about the release kinetics of the drugs from different substrates and

Abstract The crystal structures of zinc complexes 1 and 3 were determined following synthesis via a one-pot method involving the reaction of 2-hydro-6-methyl-nicotinonitrile and 2-cyanopyridine with different l-amino alcohols mediated by 120–130 mol% ZnCl2. Copper complex 4 and cobalt complex 5 were prepared by reacting (R)/(S)-a-phenylethylamine with dimethyl dichloride silane in the presence of 52 mol%

Abstract In this study, a facile, low cost, and scalable sol–gel method has been proposed for the coating of ultra-thin layer of TiO2 on FTO substrate as a seed layer for the growth of 3D-TiO2 nanorod (3D-TiO2-NR) arrays on FTO. Then, the two-step hydrothermal process including nanorod growth and the chemical etching treatment was proceeded for the fabrication of FTO/3D-TiO2-NR photoanodes. The thickness

Abstract A new, cheap, and accessible method has been used for the preparation of nano-belts from the chemical decomposition (top-down approach) of a cheap stainless steel screw and found as an efficient magnetically recyclable nanocatalyst for the preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild reaction conditions. The nano-belts, Fe–Cr–Ni oxide alloy, was prepared in a two-step

Abstract In this research, a sensitive and selective electrochemical sensor based on bimetallic gold (Au) and palladium (Pd) nanoparticles coated on mixture of reduced graphene oxide (rGO) and multiwall carbon nanotube (MWCNTs) nanocomposite was constructed by using glassy carbon electrode which has been developed for determination of an organophosphorus (OPs) insecticide, Diazinon. Au–Pd/rGO–MWCNTs

Abstract Therapeutically important bioactive polyphenols were efficiently extracted from Garcinia indica using ultrasound-assisted extraction (UAE) technique and investigated for its antioxidant and anticancer activities. Response surface methodology-based central composite face-centered experimental design and adaptive neuro-fuzzy inference system were efficiently applied to optimize the effect of

Abstract A series of 1,2,4-triazole-schiff hybrids were synthesized and characterized by mass spectrometry, FTIR and NMR spectroscopy. The compounds were screened for anticancer activity against human breast cancer cell line (MCF-7 and T47D) and human cervical cancer cell line (HeLa). The result indicates that newly synthesized compounds exhibit cytotoxicity to all cell lines studied. In particular

Abstract Graphene-based hybrid nanomaterials are interestingly being considered in expanding fields such as supercapacitors, biosensors, biomedicine, and pathogen deactivation. Surface properties of the two-dimensional (2D) hybrids are crucial in dictating their safety and efficacy. Therefore, concise and accurate functionalization of the pristine 2D nanomaterials is very important for facilitating

Abstract This study investigates the effects of temperature (50–80 °C), time (10–60 min), carob-to-solvent ratio (2–8 g/40 mL), and solvent concentration (0–50 ethanol/water%, v/v) on microwave-assisted extraction of d-pinitol compound from carob fruit with optimization using Box–Behnken design. The optimal conditions for maximum d-pinitol yield (64.16 g/kg dry sample) include 50 °C temperature, 5

Abstract The present study was aimed to synthesize and characterize monometallic complex of Cu(II) using different diamines, i.e., 4-chloro-1,2-phenylenediamine and 4-fluoro-1,2-phenylenediamine, in the presence of CuCl2 to form complexes of the type [Cu(C12H14N4Cl2)]Cl2 and [Cu(C12H14N4FCl)]Cl2. These synthesized complexes were further treated with organotin dichlorides (R2SnCl2), where R = CH3 and

Abstract A novel series of 1,2,3-triazole containing sulfonamide moiety was synthesized. Treatment of 4-acetyl 1,2,3-triazole 3 with different aldehydes gave α,β-unsaturated ketones 4a–c. Condensation of 3 with dimethylformamide dimethylacetal (DMF-DMA) gave formimidamide 5. Chalcone 7 was achieved via two ways from the reaction of 5 with benzaldehyde or from treatment of 4a with DMF-DMA. Reaction

The purpose of this research is to investigate the residues of imidacloprid and penconazole in cucumbers, since pesticides have been highly demanded in the production of greenhouse crops. According to Codex Alimentarius Commission statement, the maximum residue limits (MRLs) for imidacloprid and penconazole in cucumber are 1 and 0.06 mg kg−1, respectively. To have samples under control, cucumbers were

Belonging to the category of catecholamine-based medications, isoprenaline is excessively beneficial in the heart disease management. Nevertheless, serious adverse consequences can occur following the consumption of high concentrations of this drug. The present study aimed for highly sensitivity co-detection of isoprenaline and paracetamol in aqueous solutions by designing and synthesizing a novel

In this study, nanoparticles of CuFe2O4@SiO2@PTMS@Tu@Ni(II) as the reusable magnetic catalyst were prepared. Synthesis of the Ni(II)–CuFe2O4 system was carried out through a five-step procedure including the preparation of CuFe2O4 as the prime magnetic core, layering of silica, 3-chloropropyltrimethoxysilane and thiourea and finally the immobilization of Ni(OAc)2·4H2O. The prepared nanocomposite system

The aim of this study is to develop a selective liquid chromatographic method for the simultaneous determination of tamsulosin HCl and dutasteride which are used for prostate treatment, in the context of an analytical column that is packed with superficially porous particles. Therefore, compositions of the mobile phase were determined for the best separation of these compounds. For this reason, experimental

Abstract The potent, selective, and consistent electrochemically polymerized helianthin dye modified carbon paste electrode (PHLDMCPE) was generated for the assessment of the significant antioxidant riboflavin (RL) with ascorbic acid (AA) and tyrosine (TR) using cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. The PHLDMCPE explicates a superior electrocatalytic resolution

Herein, the building block synthon 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)acryloyl chloride 4 was synthesized and utilized for construction of a wide variety of nitrogen heterocycles encompassing a pyrazole scaffold via treatment with some nitrogen nucleophiles. The seven membered heterocycles 14–16 and 20 were constructed from the reaction of the acid chloride 4 with 1,4-binucleophilic reagents such

A novel method for the incorporation of iridium nanoparticles into a hypercrosslinked polystyrene matrix is developed using supercritical CO2 as reaction medium. The composite has regularly distributed iridium nanoparticles with monomodal size of ca 5 nm. The catalyst shows high activity in the hydrogenation of benzene and can be recycled ten times without any decrease in productivity. The catalyst

The present study describes a new reversed flow injection chemiluminescence method for the determination of the sunset yellow dye in drink samples. This method is based on the dye’s inhibition effect on the emission of chemiluminescence light (CL) generated from the luminol–H2O2–Co(II) system, in a way that a decrease in CL intensity is proportional to the concentration of the dye. The linear calibration

The article “Fe3O4@SiO2-PTMS-Guanidine-SA nanoparticles as an effective and reusable catalyst for the synthesis of N‑substituted pyrroles”, written by Hedieh Rostami · Lotfi Shiri, was originally published electronically on the publisher’s Internet portal (currently SpringerLink) on 21 January 2020 with open access. With the author(s)’ decision to step back from Open Choice, the copyright of the article

Modified sodium dodecyl benzene sulfonate Mg–Al and Zn–Al layered double hydroxides (abbreviated as Mg–Al–SDBS and Zn–Al–SDBS LDHs) were synthesized and characterized by FT-IR, TGA, XRD, BET and SEM. SEM images confirmed the platelike morphology for the synthesized LDHs, with a thickness of < 100 nm for the Mg–Al and Zn–Al LDHs modified by sodium dodecyl benzene sulfonate. This modification enhanced

Heavy metals belong to a group of lethal environmental pollutants. Ongoing efforts targeted at safeguarding public health have led to considerable attention being focused on methods that allow efficient extraction of these toxic substances. Polymer nanocomposites (PNCs) with their special characteristics are a class of adsorbents that demonstrate high potential for use in heavy metal extraction. As

Abstract This paper reports a novel disulfide-directed Csp2–H hydroxylation cascade reaction strategy catalyzed by Cu2(TPTC), a metal–organic framework material with binuclear Cu(II) paddlewheel nodes. In the strategy, Cu2(TPTC) MOF can effectively catalyze the coupling reaction of disulfide and arylboronic acid, and realize the disulfide-directed Csp2–H hydroxylation reaction. This reaction proceeded

Abstract The reaction of perfluoropyridines with indoles and bis(indolyl)methanes (BIMs) was investigated. The aromatic nucleophilic substitution of pentafluoropyridine with indoles occurs at the 4-position of pyridine ring by nitrogen site of indolyl anion, while reaction with 2,3,5,6-tetrafluoro-4-(phenylsulfonyl)pyridine gave a mixture of products arising substitution at 2-position of pyridine ring

In the present study, the deep eutectic solvent-based extraction method has been developed for separation of Zn prior to ICP-OES analysis. Five different choline chloride-based deep eutectic solvents were prepared. The Zn extraction ability of DESs from milk powder and baby formulation samples which contain a high amount of milk protein was investigated. The parameters affecting the extraction efficiency

In the present work, a novel platform has been designed to fabricate an electrochemical sensor composed of chitosan nanofibers modified with sodium dodecyl sulfate, a negatively charged surfactant, and hemoglobin protein for direct and sensitive determination of hydrogen peroxide. Chitosan nanofibers were synthesized through the electrospinning process and characterized by Fourier transform infrared

Simultaneous removal of three pollutants (diethyl phthalate, butylated hydroxy anisole and butylated hydroxy toluene) that appear in plastic industries’ wastewater was the aim of this study. These compounds have harmful effects on human health. The adsorbent, Sesamum indicum seeds’ waste, is a natural adsorbent which was obtained freely and abundantly from a local market after being oil-pressed. For

Fe3O4@SiO2-PTMS-Guanidine-SA nanoparticles used as an effective catalyst for the synthesis of N-substituted pyrroles. Pyrroles were synthesized from the reaction between primary amine derivatives and 2,5-hexanedione with high to excellent yields under mild reaction conditions. After completion of the reaction, Fe3O4@SiO2-PTMS-Guanidine-SA magnetic nanoparticles could be recovered easily from the reaction

Three phenyl dimer compounds, namely 3,3′-Diformyldiphenoxyethane (C16H14O4) (1), 1-(4-[2-(4-Acetyl-phenoxy)-ethoxy]-phenyl)-ethanone (C17H16N2O3) (2), 1-{4-[2-(4-Acetyl-phenoxymethyl)-benzyloxy]-phenyl}-ethanone (C24H22O4) (3), were obtained and fully characterized, including their crystal structure determinations. The structural properties of two compounds 4, 4′-(ethylenedioxy)dibenzaldehyde) (C16H14O4)

New, simple and rapid spectrophotometric methods were described for the micro-determination of some rare earth metal ions uranium(VI), samarium(III) and cerium(III) using a new synthesized sulfacetamide azo dye derivative [2-((4-(N-acetylsulfamoyl)phenyl)diazenyl)-3,4,5-trihydroxybenzoic acid] (APDB). The new reagent was reacted with the three rare earth metal ions forming colored complexes at 500