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PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation J. Chem. Res. (IF 0.593) Pub Date : 2021-01-12 Xiaofang Wu; Lei Zhou; Fangshao Li; Jing Xiao
A PCl3-mediated conversion of tert-butyl esters into esters and amides in one-pot under air is developed. This novel protocol is highlighted by the synthesis of skeletons of bioactive molecules and gram-scale reactions. Mechanistic studies revealed that this transformation involves the formation of an acid chloride in situ, which is followed by reactions with alcohols or amines to afford the desired
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Highly active carbon nanotube–promoted Rh-Mn-Li/SiO2 catalysts for the synthesis of C2+ oxygenates from syngas J. Chem. Res. (IF 0.593) Pub Date : 2021-01-07 Jun Yu; Ying Han; Guoqing Chen; Xiuzhen Xiao; Haifang Mao; Dongsen Mao
The effect of carbon nanotubes on the catalytic properties of Rh-Mn-Li/SiO2 catalysts was investigated for CO hydrogenation. The catalysts were comprehensively characterized by means of X-ray power diffraction, N2 sorption, transmission electron microscope, H2–temperature-programmed reduction, CO–temperature-programmed desorption, temperature-programmed surface reaction, and X-ray photoelectron spectroscopy
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Synthesis, crystal structure, and magnetic properties of a nitronyl nitroxide biradical-coordinated copper(II) complex J. Chem. Res. (IF 0.593) Pub Date : 2020-12-29 Yan-Li Gao; Pingqiang Gao; Ying Gong; Guoyu Ren
A coordination compound constructed from a nitronyl nitroxide biradical NITPh(3-NIT) and CuII(hfac)2(H2O)2 building blocks [NITPh(3-NIT) = 1,3-bis(1′-oxyl-3′-oxido-4′,4′, 5′, 5′-tetramethyl-4,5-dihydro-1H-imidazol-2-y1)-benzene, hfac = hexafluoroacetylacetonato] is successfully synthesized. The crystal structure is determined by X-ray single-crystal diffraction. The asymmetric complex {[(NITPh(3-NIT)]Cu(hfac)2}
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Thiol-independent peptide ligation: A review of mechanisms J. Chem. Res. (IF 0.593) Pub Date : 2020-12-29 Colin T Bedford
The mechanisms of several types of thiol-independent peptide ligation reported over the past 14 years have been reviewed.
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Synthesis and anti-acetylcholinesterase activities of novel glycosyl coumarylthiazole derivatives J. Chem. Res. (IF 0.593) Pub Date : 2020-12-23 You-Xian Wang; Shu-Hao Liu; Zhong-Bai Shao; Lian-Gong Cao; Kai-Jun Jiang; Xing Lu; Lei Wang; Wei-Wei Liu; Da-Hua Shi; Zhi-Ling Cao
Eleven glycosyl coumarylthiazole derivatives are synthesized by cyclization and condensation of glycosyl thiourea with 3-bromoacetyl coumarins in ethanol. The reaction conditions are optimized and good yields of products (80%–95%) are obtained. The structures of all new products were confirmed by IR, 1H and 13C NMR, and by HRMS (electrospray ionization). The in vitro acetylcholinesterase (AChE) inhibitory
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Triterpenoids with α-glucosidase inhibitory activities from the roots of Codonopsis pilosula var. modesta J. Chem. Res. (IF 0.593) Pub Date : 2020-12-17 Bing Li; Ru-Yue Wang; Ye Zhao; Yi-Fan Yu; Zhan-Xin Zhang; Fang-Di Hu; Kun Gao; Dong-Qing Fei
A new taraxerane-type triterpenoid, codopimodol A (1), together with two known triterpenoids (2 and 3), were isolated from the EtOH extract of the roots of Codonopsis pilosula var. modesta (Campanulaceae). The structure of the new compound was identified by high-resolution electrospray ionization mass spectrometry and extensive spectroscopic analyses, particularly one-dimensional and two-dimensional
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Application of molecularly imprinted polymers for the separation and detection of aflatoxin J. Chem. Res. (IF 0.593) Pub Date : 2020-12-17 Jian-Xiong He; Huan-Yu Pan; Li Xu; Ri-Yuan Tang
Aflatoxins are extremely harmful carcinogens to humans and animals. In recent years, attention has been directed toward the application of molecular imprinting polymers for the separation and detection of aflatoxin. In this review, polymerization methods for the preparation of molecular imprinting polymers for aflatoxin detection, such as lump-bulk polymerization, spherical molecular imprinting polymer
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Synthesis, structure, fluorescence, electrochemical, and antioxidant studies of a new silver(I) complex with 2,6-bis(N-methylbenzimidazol-2-yl)pyridine J. Chem. Res. (IF 0.593) Pub Date : 2020-12-16 Lixian Xia; Xinzhao Xia; Geng Zhang; Yancong Wu; Huilu Wu; Jianhua Xu
A new silver(I) complex of the type [Ag2(mbbp)2](pic)2·DMF·CH3OH [mbbp = 2,6-bis(N-methylbenzimidazol-2-yl)pyridine] is synthesized and analyzed using a range of spectroscopic and crystallographic techniques. This compound contains cationic Ag2(mbbp)2 dimers, in which the crossed eight-shaped structure is formed by two mbbp ligands bridging two silver(I) centers and Ag–Ag bonds. Two-dimensional supramolecular
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Molecular docking and density functional theory studies on creatine, guanidinoacetic acid, and their phosphorylated analogues binding to muscle creatine kinase J. Chem. Res. (IF 0.593) Pub Date : 2020-12-14 M Vraneš; S Ostojić; Č Podlipnik; A Tot
Comparative molecular docking studies on creatine and guanidinoacetic acid, as well as their phosphorylated analogues, creatine phosphate, and phosphorylated guanidinoacetic acid, are investigated. Docking and density functional theory studies are carried out for muscle creatine kinase. The changes in the geometries of the ligands before and after binding to the enzyme are investigated to explain the
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Synthesis, characterization, crystal structures, and the biological evaluation of 2-phenylthiazole derivatives as cholinesterase inhibitors J. Chem. Res. (IF 0.593) Pub Date : 2020-12-13 Da-Hua Shi; Meng-qiu Song; Xiao-Dong Ma; Jia-Bin Su; Jing Wang; Xiu-Jun Wang; Yu-Wei Liu; Wei-Wei Liu; Xin-Xin Si
Four 2-phenylthiazole derivatives are synthesized, characterized, and evaluated as cholinesterase inhibitors. The structures of the 2-phenylthiazole derivatives are confirmed by 1H and 13C nuclear magnetic resonance spectroscopy, single-crystal X-ray diffraction studies, and Hirshfeld surfaces analysis. Hirshfeld surface analysis of the prepared compounds showed C–H···O intermolecular interactions
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Liquid chromatography–mass spectrometry analysis of dyes formed by in situ oxidative methods then purified by absorption and extraction from hair wefts J. Chem. Res. (IF 0.593) Pub Date : 2020-12-13 M John Plater; Andrea Raab
The dye mixtures formed from three commercial hair colour formers were purified by absorption onto human hair wefts, washed and dried, extracted with dichloromethane:trifluoroacetic acid (75:25) and then analysed by liquid chromatography–mass spectrometry. Only 1–2 dyes were identified from each complex mixture of commercial aromatic amines along with a broad UV absorption mainly consisting of mixtures
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Activated carbons from coffee husk: Preparation, characterization, and reactive red 195 adsorption J. Chem. Res. (IF 0.593) Pub Date : 2020-12-10 Thu Thuy Luong Thi; Huu Son Ta; Khu Le Van
Activated carbons are prepared from coffee husks by chemical activation with ZnCl2 and are characterized by employing Brunauer, Emmett and Teller, scanning electron microscopy, Fourier-transform infrared spectroscopy, and Boehm titrations. The effects of ZnCl2/coffee husks, activation temperature, and activation time are studied, and the results show that the sample ACZ3-600-2 has a high surface area
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Theoretical and experimental studies on the fluorescence properties of aluminum(III), cadmium(II), zinc(II), and copper(II) complexes of substituted 8-hydroxyquinoline J. Chem. Res. (IF 0.593) Pub Date : 2020-12-10 Zhang Yuanyuan; Cheng Hongrui; Sun Qingrong; Chen Hongli; Yang Weiqing; Ma Menglin
Fifty-five 8-hydroxyquinoline (8-HQ) derivatives are synthesized and the corresponding aluminum(III), cadmium(II), copper(II), and zinc(II) metal complexes are prepared and their fluorescent activities are evaluated. The results indicate that the aluminum complexes have the best fluorescence properties, followed by zinc and cadmium complexes, while almost no fluorescence is observed with the copper
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An expedient, one-pot, stepwise sequential approach for the regioselective synthesis of pyrazolines J. Chem. Res. (IF 0.593) Pub Date : 2020-12-09 Suresh Ganesan; Muniraj Sarangapani; Mukesh Doble
An efficient approach for the synthesis of pyrazoline/pyrazole-tethered pyridinyl methanones is described via a one-pot, stepwise, sequential methodology using chalcones and pyridine-4-carbohydrazide as substrates through a Michael addition followed by cyclization. The reaction proceeds via a catalyst-, solvent-, work-up-, and column-chromatography-free method under melt conditions to provide the pyrazolines
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Synthesis of 3-alkyl-1,2,3-triazol-1-ium hydrogen sulphate derivatives J. Chem. Res. (IF 0.593) Pub Date : 2020-12-09 Pilar González-Perdomo; Jaime González; Diego Martínez-Otero; MV Basavanag Unnamatla; Marco A García-Eleno; David Corona-Becerril; Erick Cuevas-Yañez
An array of 3-alkyl-1,2,3-triazol-1-ium hydrogen sulphate derivatives was obtained from the reaction between some 1,4-disubstituted-1,2,3-triazoles and H2SO4 through a simple protocol in good yields. The molecular structure of a triazolium salt (R1 = PhCH2, R2 = CH2O(4-CHO)C6H4) was unambiguously determined from X-ray diffraction studies, showing a remarkable triazole N3–H bond.
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A highly selective fluorescent probe for the sensing of Cu2+ based on the hydrolysis of a quinoline-2-carboxylate and its application in cell imaging J. Chem. Res. (IF 0.593) Pub Date : 2020-11-30 Qihua You; Yihua Zhuo; Yadong Feng; Yujuan Xiao; Yanyu Zhang; Lei Zhang
A highly selective OFF–ON fluorescent probe is developed for the sensing of Cu2+ based on the hydrolysis of a quinoline-2-carboxylate moiety. The probe is weakly fluorescent due to esterification of the phenolic group. Upon treatment with 1 equiv. of Cu2+, the probe exhibits strong fluorescence at 570 nm. The probe also exhibits high selectivity for Cu2+ over other cations with a low detection limit
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Synthesis of hydroxy-α-sanshool J. Chem. Res. (IF 0.593) Pub Date : 2020-11-26 Jianjun Zhou; Yan Xiao; Taiping Chen; Jiyu Gao; Wencai Huang; Zicheng Li
Hydroxy-α-sanshool was synthesized in a 13% overall yield through eight steps, which included two Wittig reactions that were used to form the carbon skeleton with ethyl 2-oxoacetate and 2E,4E-hexadienal being reacted with the appropriate ylides. Impurities in the processes could easily be separated. Ethyl 6-hydroxy-2Z-hexenoate was converted to its E-isomer with catalysis by I2 and 2E,6Z,8E,10E-dodecatetraenoic
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Acidic hydrolysis of astilbin and its application for the preparation of taxifolin from Rhizoma Smilacis Glabrae J. Chem. Res. (IF 0.593) Pub Date : 2020-11-25 Xiao-Lin Qiu; Qing-Feng Zhang
The acidic hydrolysis of astilbin to produce its aglycone, taxifolin, was investigated in this study. The effects of aq. HCl concentration and temperature on the reaction were studied, and the kinetic parameters were calculated. The results showed that with higher aq. HCl concentration and temperature, the hydrolysis of astilbin became faster. The activation energy of the hydrolysis reaction under
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Preparation, crystal structures, properties, and time-dependent density functional theory of two cobalt complexes with 3-hydroxy-2-methyl-quinoline-4-carboxylate J. Chem. Res. (IF 0.593) Pub Date : 2020-11-25 Xiu-Guang Yi; Fei-Ping Lai; Yun-Yi Yan; Cong Zhang; Wen-Ping Li
One organic compound [HMCA]2 (1) and two novel cobalt complexes [Co(MCA)(bipy)(H2O)]·(H2O) (2), [Co2(MCA)2(Phen)3]·3(H2O) (3) are synthesized by a solvothermal approach and are structurally determined by single-crystal X-ray diffraction. Compound 1 exhibits a two-dimensional structure by hydrogen bond and π. . .π stacking interaction. The complexes exhibit a three-dimensional and one-dimensional metal-organic
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Preparation of extra-large micropore Sn-zeolites and their catalytic performance in Baeyer–Villiger oxidations J. Chem. Res. (IF 0.593) Pub Date : 2020-11-25 Boting Yang; Tianxiao Cui
A series of extra-large micropore Sn-zeolites with different Si/Sn ratios is post-synthesized by treating the interlayer-expanded material ECNU-9-cal773 with a solution of HCl containing NH4F and SnCl4∙5H2O, named as IEZ-Sn-PLS-3(S4R). During treatment, HCl, NH4F, and SnCl4∙5H2O are hydrolyzed into H+, F+, and Sn4+ ions. The formation of a small amount of HF formed from H+ and F+ ions can corrode the
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Experimental and an electrolyte non-random two-liquid model to predict the vapor–liquid equilibrium of CO2 in aqueous solutions of diethylenetriamine J. Chem. Res. (IF 0.593) Pub Date : 2020-11-25 Ruilei Zhang; Yandong Tang; Weifeng Shan; Haijun Liu; Haijun Li; Jian Chen
The absorption and desorption data of CO2 in aqueous solutions with a mass fraction of 10% and 20% of diethylenetriamine are measured at 313.15, 343.15, 373.15, and 393.15 K. The electrolyte non-random two-liquid theory is developed using Aspen V9.0 to correlate and predict the vapor–liquid equilibrium of CO2 in aqueous diethylenetriamine solutions. The model predicted the heat capacity and saturated
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A facile method to synthesize vildagliptin J. Chem. Res. (IF 0.593) Pub Date : 2020-11-25 Li Zhang; Lan Jiang; Xiaoshu Guan; Linhong Cai; Jingyu Wang; Peng Xiang; Junyi Pan; Xiangnan Hu
An efficient and high-yielding synthetic method for the preparation of vildagliptin via four steps is reported. The process starts from L-proline and involves a successful reaction with chloroacetyl chloride in tetrahydrofuran to afford (S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid, followed by a reaction with acetonitrile in the presence of sulfuric acid to give (S)-1-(2-chloroacetyl)pyrrol
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The effects of metals and ligands on the oxidation of n-octane using iridium and rhodium “PNP” aminodiphosphine complexes J. Chem. Res. (IF 0.593) Pub Date : 2020-11-25 Dunesha Naicker; Saba Alapour; Holger B Friedrich
Ir and Rh “PNP” complexes with different ligands are utilized for the oxidation of n-octane. Based on the obtained conversion, selectivity, and the characterized recovered catalysts, it is found that the combination of Ir and the studied ligands does not promote the redox mechanism that is known to result in selective formation of oxo and peroxo compounds [desired species for C(1) activation]. Instead
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Self-standing magnetic composite nanosheets prepared in the presence of an external magnetic field: Characterization and potential for medical applications J. Chem. Res. (IF 0.593) Pub Date : 2020-11-25 Mina Sakuragi; Yoshikazu Takahashi; Keito Ehara; Katsuki Kusakabe
The aim of this study is to develop self-standing, ultrathin film, nanosheets with high magnetic response for use in a medical device that can be migrated to a target location in the body by using an external magnetic field. First, iron oxide nanoparticles are synthesized by either the sol-gel method or thermal decomposition. The resulting magnetic properties of the nanoparticles show that the thermal
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Synthesis and catalytic properties of a novel copper- and manganese-substituted cerium dioxide for benzene remediation J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Jae Hwan Yang; Jeong Hyun You
Catalysts based on inexpensive and abundant transition metals are necessary for effective environmental remediation. In this study, a series of CuMn-CeO2 catalysts is synthesized by a simple coprecipitation method. The properties of the as-prepared catalysts are characterized by X-ray diffraction, Brunauer–Emmett–Teller analysis, scanning electron microscopy–energy-dispersive spectroscopy, transmission
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Synthesis of a potential bendamustine deschloro dimer impurity J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Jie Yuan; Hai-Bin Zhu
Bendamustine deschloro dimer was considered as a potential impurity in bendamustine hydrochloride resulting from the hydrolysis of bendamustine followed by intermolecular esterification. An efficient synthesis of bendamustine deschloro dimer was achieved from 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate involving nine sequential steps including benzyl-protection/deprotection of the amine
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Quantum mechanical investigations of base-catalyzed cycloaddition reaction between phenylacetylene and azidobenzene J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Mohammad Abd Al-Hakim Badawi; Sultan T Abu-Orabi
In this study, the mechanism for both the Huisgen 1,3-dipolar cycloaddition and the base-catalyzed cycloaddition reactions between phenylacetylene and azidobenzene has been investigated with density functional theory, namely at the M06-2X/6-31G(d) computational level. Later, the reaction has been modeled with a representative simple alkyne and a simple azide to concentrate solely on how the difference
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One-pot synthesis of 3-substituted-4H-[1,2,3] triazolo[5,1-c][1,4]oxazin-6(7H)-ones from propargyl alcohols, chloroacetyl chloride, and sodium azide J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Xiao-Lan Zhang; Mei-Hong Wei; Jun-Min Chen; Shou-Ri Sheng; Xiao-Ling Liu
An efficient, one-pot synthesis of 3-substituted-4H-[1,2,3]triazolo[5,1-c][1,4]oxazin-6(7H)-ones is developed via sequential esterification, substitution, and 1,3-dipolar cycloaddition processes of various propargyl alcohols, chloroacetyl chloride, and sodium azide. This method provides a variety of novel 1,2,3-triazole-fused oxazinones and has several advantages including simple operation, high efficiency
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Preparation and characterization of two lanthanide complexes with one-dimensional chain-like structures J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Hui Luo; Wen-Tong Chen
Two novel RE–Hg (RE = rare earth) complexes [RE(IA)3(H3O)2]2n·2n(HgCl4)·n(HgCl5)·nH2O·3nH3O (RE = Y, 1; Lu, 2; IA = isonicotinic acid anion) were synthesized through hydrothermal reactions and are structurally characterized by single-crystal X-ray diffraction. The two complexes are isostructures and are characteristic of a one-dimensional chain-like structure. Both complexes are characterized by a
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Synthesis, in vitro anticancer activities, and quantum chemical investigations on 1,3-bis-(2-methyl-2-propenyl)benzimidazolium chloride and its Ag(I) complex J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Goncagül Serdaroğlu; Serap Şahin-Bölükbaşı; Duygu Barut-Celepci; Resul Sevinçek; Neslihan Şahin; Nevin Gürbüz; İsmail Özdemir
1,3-Bis-(2-methyl-2-propenyl)benzimidazolium chloride and its Ag(I) complex are synthesized and the structures are elucidated using spectroscopies techniques. The molecular and crystal structures of the benzimidazolium salt are confirmed by X-ray crystallography. The molecular geometries of the benzimidazolium and its Ag(I) salt are analyzed using the B3LYP functional with the 6–311+G(d,p)/LANL2DZ
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Cu-catalyzed cross-coupling of methyl ketones and pyridin-2-amines for the synthesis of N-(2-pyridyl)-α-ketoamides J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Ali Chen; Daji Yang; Yue Yu; Xiang Liu; Chuixiong Rao; Haoming Lin; Pengfeng Guo
An efficient copper-catalyzed strategy for the synthesis of α-ketoamides via cross-coupling of methyl ketones and pyridin-2-amines is described. This transformation has provided a simple process for the formation of C−N and C=O bonds to prepare α-ketoamides, which are important substrates and intermediates for the preparation of fine chemicals. The reaction mechanism is investigated, which suggests
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Chloro- and BF2bdk-substituted dithienylethene: Synthesis, photophysical properties, and optical switching behavior J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Zhiqiang Lu; Wenbo Yang; Yanhui Bai; Mo Wang; Zixu Li; Yang Yang; Xueling Feng; Yuanxiao Zhu; Xujia Yang; Ziyong Li
A novel chloro- and BF2bdk-substituted dithienylethene derivative, in which a chlorine atom and a difluoroboron β-diketonate (BF2bdk) group are appended at the termini of the dithienylethene core, is developed. The structure was confirmed by 1H NMR, 13C NMR, and high-resolution mass spectrometry (electrospray ionization). It displayed solvent-dependent photophysical properties, and blue/red light-triggered
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Simple, novel, and efficient synthesis of ethyl 2-(2-(1H-indol-3-yl)benzo[d]thiazol-3(2H)-yl)-2-cyanoacetate or acetate via a three-component reaction J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Mahmoud Nassiri; Forough Jalili Milani
Ethyl 2-(2-(1H-indol-3-yl)benzo[d]thiazol-3(2H)-yl)-2-cyanoacetate or acetate 6a–f as a series of novel compounds were synthesized from the reactions of benzothiazole, 2-methylbenzothiazole, or 2,5-dimethylbenzothiazole and ethyl bromocyanoacetate with indole derivatives. The reactions proceeded in acetone as a solvent under reflux for 5 h in good yields. The structures of new compounds were confirmed
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A photoelectrochemical biofuel cell based on a TiO2 nanotube array fluorine-doped tin oxide photoanode J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Chunping Xiao; Lili Ji; Dehui Li; Louqun Wang; Jing Yang
Photoelectrochemical biofuel cells can convert light and chemical energy into electrical energy using a dye-sensitized titania (TiO2) fluorine-doped tin oxide photoanode and a platinum-coated fluorine-doped tin oxide cathode. TiO2 of the photoanode serves both as a support for dyes and as an electron-transporting medium, the structure of which can limit electron trapping and charge transporting and
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Green synthesis of water-soluble fluorescent carbon dots from rosemary leaves: Applications in food storage capacity, fingerprint detection, and antibacterial activity J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Hasan Eskalen; Mustafa Çeşme; Süleyman Kerli; Şükrü Özğan
Blue fluorescent carbon dots are synthesized via a one-step hydrothermal method using rosemary leaves as a carbon source. The obtained carbon dots are characterized by X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectroscopy, UV-Vis, FTIR, and fluorescence spectrometry. The results show that carbon dots gave a maximum emission peak at 422 nm when excited at 332 nm. The
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An efficient one-pot synthesis and biological evaluation of novel (E)-2-aroyl-4-arylidene-5-oxotetrahydrofuran derivatives J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Hong-Mei Wang; Xiu-Lian Zhu; Qin-Hua Chen; Ming-Wu Ding; Xiao-Hua Zeng
An efficient one-pot base-mediated approach to (E)-2-aroyl-4-arylidene-5-oxotetrahydro-furans is developed. Nine (E)-2-aroyl-4-arylidene-5-oxotetrahydrofurans are synthesized in good yields via tandem Passerini and cyclization reactions, starting from Baylis–Hillman acids, aryl glyoxals, and isocyanides at room temperature in the presence of Cs2CO3. In addition, the MTT assay is used to evaluate their
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Novel synthesis of furancarboxylate derivatives via cyclization reactions of (E)-ethyl 3-aryl-2-cyanoacrylates and ethyl glycinate hydrochloride J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Naili Luo; Shan Wang; Zhenjie Su; Cunde Wang
An efficient synthetic approach for the preparation of densely substituted furans starting from (E)-ethyl 3-aryl-2-cyanoacrylates and ethyl glycinate hydrochloride mediated by 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of water is investigated. The reactions are carried out under mild conditions in N,N-dimethylformamide at 95 °C. The products are cleanly obtained in 50%–57% yields, resulting
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Synthesis of quinone-based heterocycles of broad-spectrum anticancer activity J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Ashraf A Aly; Alaa A Hassan; Nasr K Mohamed; Mohamed Ramadan; Amal S Abd El-Aal; Stefan Bräse; Martin Nieger
A synthesis of benzo[e][1,2,4]triazines and 1,2,4-triazolospiro[4,5]deca-2,6,9-trien-8-ones has been developed from reactions of amidrazones with 2-chloro-1,4-benzoquinone in EtOAc containing 0.5 mL of piperidine. This highly regioselective and one-pot process provided rapid access to 1,2,4-triazolospiro[4,5]deca-2,6,9-trien-8-ones (60%–70%) and benzo[e][1,2,4]triazines (11%–18%). On reacting amidrazones
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The kinetics and mechanism of the ligand substitution reaction of aquapentacyanoruthenate(II) with d-penicillamine in aqueous medium J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Rupal Yadav; Radhey Mohan Naik
The kinetics of the formation of the light orange–coloured complex [Ru(CN)5D-PA]3− are studied spectrophotometrically through substitution of a coordinated H2O molecule in aquapentacyanoruthenate(II) [Ru(CN)5OH2]3− by interaction with D-penicillamine [D-PA] in aqueous medium at 490 nm (λmax of [Ru(CN)5D-PA]3−). The reaction is monitored under pseudo-first-order conditions, taking [D-PA] in excess over
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A practical and scalable synthesis of KRN7000 using glycosyl iodide as the glycosyl donor J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Yang Zhang; Jia Guo; Xiaoyan Xu; Qi Gao; Xianglai Liu; Ning Ding
KRN7000 is particularly useful because it is a powerful and specific CD1d agonist and has prompted intense interest in the context of immunology in the past 25 years. Its limited commercial availability and high price has led to the publication of many different syntheses. However, almost all of them focused on the methodology development rather than a scalable synthesis. Herein, we have described
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X-ray structure of an unusual glycoluril derivative conformation: Structural analysis and influencing factors J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Jungang Wang; Shanghui Yang; Qiling Zou; Huanjiang Wang; Hongqing Li
The synthesis and X-ray structure of a novel glycoluril derivative are described. The crystal of the glycoluril derivative is obtained by slow evaporation in a refrigerator at about 5 °C. X-ray crystallographic analysis revealed that the compound crystallized in an unusual as conformation instead of the usual clip-shaped aa conformation. Structural analysis shows that the solvation effect, hydrogen
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A new 11,10-guaiane-type sesquiterpenoid from the roots of Stellera chamaejasme Linn J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Fei-Feng Hu; Dan-Dan Qi; Sha Xu; Wei Mao
Chamaejasmone F, a new 11,10-guaiane-type sesquiterpenoid, is isolated from the roots of Stellera chamaejasme Linn., along with four known compounds including two guaiane sesquiterpenoids and two lignans. The structure of the new compound is elucidated by extensive spectroscopic analysis, especially two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization
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An efficient multicomponent synthesis of 1H-pyrano[2,3-d]pyrimidine-2,4(3H,5H)-dione derivatives and evaluation of their α-amylase and α-glucosidase inhibitory activity J. Chem. Res. (IF 0.593) Pub Date : 2020-11-24 Mamata Devendra Naik; Yadav D Bodke; Prashantha J; Jayanth K Naik
In this paper, we report the synthesis of novel 1H-pyrano[2,3-d]pyrimidine-2,4(3H,5H)-dione derivatives 5(a–j) by a facile multicomponent reaction. The structures of all the newly synthesized compounds were characterized by different spectroscopic techniques including infrared, nuclear magnetic resonance (1H and 13C) and mass spectral analysis. All the new compounds were assessed for their in vitro
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One-pot synthesis of azo compounds in the absence of acidic or alkaline additives J. Chem. Res. (IF 0.593) Pub Date : 2020-10-19 Ting-Ting Liu; Jiao-Zhao Yan; Xin-Wang Cheng; Pan Duan; Yao-Fu Zeng
A one-pot method for the synthesis of azo compounds by the reaction of β-naphthol with aryl amines using t-BuONO as the nitrosonium source in DCM at room temperature was developed. This method features mild reaction conditions, a simple experimental procedure, and is free of acidic or alkaline additives.
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Mixed ligand cobalt and palladium complexes containing triphenylphosphine and a hydrazone: Synthesis and application in non-linear optics J. Chem. Res. (IF 0.593) Pub Date : 2020-07-27 Dileep Ramakrishna
Mixed ligand complexes of cobalt and palladium containing triphenylphosphine and a hydrazone derived from furfural and hydrazine hydrate have been designed, synthesized, evaluated, and characterized from their spectral properties, elemental analysis, and magnetic susceptibility measurements. The spectral techniques suggest that the complexes exhibit square planar geometry. The monomeric properties
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Synthesis, crystal structure, and thermal properties of Ni(NH3)4(AFT)2 J. Chem. Res. (IF 0.593) Pub Date : 2020-07-26 Shu-han Wei; Xiao Ma; Zi-mei Ding; Kang-zhen Xu; Hong-xu Gao; Jie Huang; Feng-qi Zhao
Ni(NH3)4(AFT)2 [NiC6H16N18O2, AFT = 4-amino-3-(5-tetrazolate)furazan] is synthesized and characterized by elemental analysis and Fourier-transform infrared spectroscopy for the first time. X-ray diffraction measurements are used to determine the crystal structure of compound 1. The results demonstrate that compound 1 crystallized in the orthorhombic crystal system. The nickel(II) ion is six-coordinated
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Substituent effects on the structure and properties of (para-C5H4X)Ir(PH3)3 complexes in the ground state (S0) and first singlet excited state (S1): DFT and TD-DFT investigations J. Chem. Res. (IF 0.593) Pub Date : 2020-07-21 Gholamreza Ghane Shalmani; Reza Ghiasi; Azam Marjani
The ground and lowest singlet excited state geometries of selected (para-C5H4X)Ir(PH3)3 iridabenzene complexes (para-substituent = NH2, OMe, Me, H, F, Cl, CCl3, CF3, NO2) are optimized using the MPW1PW91 procedure employing the LanL2DZ(Ir) and 6-311G(d, p) (C, H, N, O, P, F, Cl, P) basis sets. The excited state is generated using the time-dependent density function method. The effects of electron-donating
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Ferrocenyl imidazolo[2,1-b]-1,3,4-thiadiazoles: A microwave-assisted catalyst-free synthesis, characterization, and biological activities J. Chem. Res. (IF 0.593) Pub Date : 2020-07-20 Yuting Liu; Lan Yang; Dawei Yin
Ferrocenyl imidazolo[2,1-b]-1,3,4-thiadiazoles are synthesized using 2-amino-5-substituted-1,3,4-thiadiazole and α-bromoacetyl ferrocene as substrates under microwave-assisted and catalyst-free conditions. The structures are characterized by infrared, 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, mass spectrometry, and elemental analysis. Compared with conventional methods, the present
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Porous carbons derived from zinc-based nitrogen heterocyclic complexes combined with KOH activation for use as supercapacitors J. Chem. Res. (IF 0.593) Pub Date : 2020-07-20 Shuai Ru; Zhaoquan Ai
2,2’-Bipyridine with strong coordination ability for metal ions was used to prepare N-doped porous carbon materials by a facile method of solution agitation and annealing, with KOH as the activated solvent. Applied to supercapacitors, these porous carbon materials exhibit high specific capacitance and outstanding rate performance, which are attributed to their larger specific surface area, richer pore
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Synthesis of an [email protected] catalyst with amorphous copper as the support and its catalytic performance in the reduction of 4-nitrophenol J. Chem. Res. (IF 0.593) Pub Date : 2020-07-17 Jian Zhang; Chenchen Qin; Luying Liu; Hanfeng Dong; Yujuan Wang; Lei Bao; Wei Gan; Xucheng Fu; Hequn Hao
The support used in a composite catalyst has an important influence on the catalytic performance of the catalyst. Amorphous metals have good electron-transfer properties and the presence of defect structures on the surface will introduce additional active sites and should be excellent catalyst supports. In this study, an [email protected] composite catalyst with amorphous Cu (a-Cu) as the support is
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Synthesis of unsymmetrical disulfides via the cross-dehydrogenation of thiols J. Chem. Res. (IF 0.593) Pub Date : 2020-07-17 Shangfeng Ren; Nianhua Luo; Kunming Liu; Jin-Biao Liu
Organosulfur compounds with unsymmetrical S–S bonds are usually called unsymmetrical disulfides and are widely used in the biological, medicinal, and chemical fields. Their versatility has guided the development of various new methods for the synthesis of disulfides. In recent years, the synthesis of disulfides by cross-dehydrogenation of thiols has attracted much attention due to its high atomic economy
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Preparation of an N-doped mesoporous carbon sphere and sheet composite as a high-performance supercapacitor J. Chem. Res. (IF 0.593) Pub Date : 2020-07-16 Xiaolin Hu; Lei Liu; Yue Zhang; Aibing Chen
Carbon-based materials with multidimensional structures generally exhibit improved properties compared with single-morphology carbon materials for various applications including catalysis, adsorption, and energy storage. Here, an N-doped mesoporous carbon sphere and sheet composite is prepared by a co-assembly strategy using an ionic liquid ([C18Mim]Br) as the structure-directing agent, ethylenediamine
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Investigations into the ligand steric and electronic effects of Ru-catalyzed C–H bond arylation directed by 8-aminoquinoline as a bidentate-directing group J. Chem. Res. (IF 0.593) Pub Date : 2020-05-28 Hamad H. Al Mamari; Yousuf Al Lawati
In this study, we report an investigation into the steric (cone angle, θ) and electronic properties of ligands in Ru-catalyzed C–H arylation of aromatic benzamides bearing 8-aminoquinoline as an N,N’-bidentate-directing group. The study employs [RuCl2(p-cymene)]2 as a precatalyst, and a ligand, under study, as a cocatalyst. Various electronically and sterically different monodentate and bidentate phosphine
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Design and synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives via click reactions J. Chem. Res. (IF 0.593) Pub Date : 2020-05-27 Tong Lu; Ling Dong; Hongmei Pan; Xuedan Wu; Xia Chen; Chengwen Gu; Naili Tao; Ao Wang; Kehua Zhang; Jie Jin
The synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives at the 4-OH via click reactions is accomplished, and a total of 16 novel sinomenine double N-heterocyclic derivatives are obtained in 74%–95% yields. The C-ring is first transformed into a 1,2-diketone structure under the action of hydrochloric acid, and then reacted with o-phenylenediamine to obtain a C-ring qui
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Structural and tribological properties of tungsten oxide thin film on a silicon substrate J. Chem. Res. (IF 0.593) Pub Date : 2020-05-20 Siamak Ziakhodadadian; Tianhui Ren
In this work, tungsten oxide thin films are deposited on silicon substrates using the hot filament chemical vapor deposition system. The influence of substrate temperature on the structural, morphological, and elemental composition of the tungsten oxide thin films is investigated using X-ray diffraction, field-emission scanning electron microscopy, and X-ray photoelectron spectroscopy techniques. Also
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A rhenium(I) complex which reacts with aldehydes and ketones in aqueous media: A structural, spectroscopic and theoretical analysis J. Chem. Res. (IF 0.593) Pub Date : 2020-05-19 Lindsay P Harding; Asuka AT McRobbie; T Riis-Johannessen; Simon JA Pope; Craig R Rice; Donna Rollinson; Martina Whitehead
A Re(I) complex of 3,3′-diamino-2,2′-bipyridine reacts irreversibly with aldehydes and unhindered ketones in water to form bis-aminal cyclised derivatives with the solid-state structure of the reaction with benzaldehyde reported. This reaction produces a Re(I) complex which is significantly more emissive than the starting compound.
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Cornifronone: A cadinane-type sesquiterpene from a mason bee (Osmia cornifrons)–derived Streptomyces sp J. Chem. Res. (IF 0.593) Pub Date : 2020-05-19 Guo-Li Li; Ze-Yu Xu; Nan Li; Zhe Wang; Tian Tian; Tong Shen
A new cadinane-type sesquiterpene named cornifronone is isolated from the body surface of a mason bee (Osmia cornifrons)–derived Streptomyces sp. OC1611-8A. Its structure is identified by high-resolution electrospray ionization mass spectrometry data and nuclear magnetic resonance spectroscopic analysis. The absolute configuration of cornifronone was determined by electronic circular dichroism spectra
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Subcritical hydrothermal synthesis of amorphous molybdenum disulfide spheres J. Chem. Res. (IF 0.593) Pub Date : 2020-05-19 Hanane Akram; Ouafae Achak; Tarik Chafik
Amorphous MoS2 spheres with diameters ranging from 150 nm to 1.5 μm are successfully prepared following a reliable one-pot hydrothermal route using a homemade autoclave and inexpensive reactants, at a low temperature (160 °C) and a short reaction time (12 h). The obtained material is comprehensively characterized by X-ray diffraction, scanning-electron microscopy, energy-dispersive X-ray spectroscopy
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A four-coordinate Cu(I)–N-heterocyclic carbene complex: Synthesis, structure, properties, and application in amination for the synthesis of 1-(2-N-heteroaryl)-1H-pyrazoles J. Chem. Res. (IF 0.593) Pub Date : 2020-05-18 Chen Xu; Hong-Mei Li; Zhi-Qiang Wang; Wei-Jun Fu
A new luminescent, cationic, heteroleptic, four-coordinate Cu(I)–N-heterocyclic carbene complex [Cu(Br-Pyim)(POP)](PF6) is successfully prepared and characterized, where Br-Pyim and POP are 1-(6-bromopyridin-2-yl)imidazole-3-benzyl-2-ylidene and bis[2-(diphenylphosphino)phenyl]ether, respectively. Its detailed structure is determined by single-crystal X-ray analysis. It exists as a crystalline powder
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Ferric chloride–catalyzed deoxygenative chlorination of carbonyl compounds: A comparison of chlorodimethylsilane and dichloromethylsilane system J. Chem. Res. (IF 0.593) Pub Date : 2020-05-14 Bing-Han Xing; Xuan-Xuan Zhao; Yu-Jun Qin; Pu Zhang; Zhi-Xin Guo
Deoxygenative chlorination of carbonyl compounds using the HMe2SiCl/FeCl3/EtOAc and HMeSiCl2/FeCl3/EtOAc systems has been systemically investigated. The HMe2SiCl-FeCl3 system showed the advantages of good substrate applicability, mild reaction conditions, simple operation, low cost, and easy availability of raw materials. Also, it provided a simple and efficient synthesis route for carbonyl deoxychlorination
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