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  • Molecular modeling and photovoltaic applications of porphyrin-based dyes: A review
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2020-01-21
    Muneerah M. Al-Mogren; Noha M. Ahmed; Ahmed A. Hasanein

    In this review, the introduction of solar cells is presented. Old and new generation solar cells are briefly described. Quantum dot solar cells (QDSCs), perovskite solar cells, and dye-sensitized solar cells (DSSCs) are concisely introduced. The sensitization mechanism in DSSCs is discussed in detail concerning the spectral and electron injection properties of different dyes. An analysis of the intramolecular charge transfer process in the excited dye molecule is also provided. The use of porphyrin-based dyes as sensitizers in DSSCs is then reviewed. The design, synthesis, and photovoltaic application of a wide variety of porphyrin-based dyes as well as porphyrin dyads are presented and discussed. Theoretical studies of the spectral and electronic properties of different porphyrin-based dyes using DFT and TD-DFT methods are described. The different possibilities for improving the light-to-electrical energy conversion performance are discussed, such as structural modifications through introducing push-pull moieties, which in turn tunes the HOMO-LUMO energy gap of the sensitizing dye used in the DSSC. Experimental, as well as theoretical calculations of adsorption energies of the sensitizing dyes, are crucial for predicting the relative performance and efficiency of the dyes.

    更新日期:2020-01-21
  • Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2020-01-16
    Nurul Syahira Zaharuddin; Eleen Dayana Mohamed Isa; Haslina Ahmad; Mohd Basyaruddin Abdul Rahman; Khairulazhar Jumbri

    Chemotherapy is the most common treatment for all cancer patients but this treatment poses many side effects due to lack of drug’s selectivity. To overcome this problem, utilizing a better and more effective delivery agent is the solution. Mesoporous silica nanoparticles (MSNs) emerged as a promising platform in development of drug delivery agent. This is due to its desirable properties such as tunable pores, large surface area, good biocompatibility and easy functionalization. Furthermore, these properties can be tuned through the utilization of alternative template such as pyridinium ionic liquid. Besides, by employing surface functionalization, the effectiveness of MSNs as drug delivery agent may also increase. This work reported the usage of 1-hexadecylpyridinium bromide ionic liquid as template for MSNs production and the surface of MSNs was then further functionalized via post – grafting method in order to obtain MSN – NH2, MSN – SH and MSN – COOH as drug carrier, respectively. These functionalized MSNs were then used to study the drug loading and drug release of hydrophilic drug, gemcitabine and hydrophobic drug, quercetin. For quercetin, MSN-NH2 had the highest drug loading percentage (72 %) and slowest release (14%) in 48 hours while for gemcitabine, it was found that MSN-COOH had the highest drug loading percentage (45 %) and slowest release (15%) in 48 hours. Based on the results, it is suggested that mesoporous silica nanoparticle with surface functionalization has suitable properties for controlled drug release which gives constant release behavior over a period of time to avoid repeated administration of drug where the drug is administered at a fixed dosage and regular time interval.

    更新日期:2020-01-17
  • Recent advances in Palladium(II)-catalyzed activation of aromatic ring C-H bonds
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2020-01-14
    Yin-ling Yun; Jie Yang; Yu-hang Miao; Jie Sun; Xiao-jing Wang

    Palladium is a precious metal, which has been widely used for various organic transformations in the past decades. Currently, the palladium-catalyzed direct activation of the aromatic ring C-H bonds is one of the frontier areas in organic chemistry, and the progress of research in this field is very rapid. Compared with other transition metals, palladium has the advantages of high catalytic activity and strong selectivity. Combining the domestic and foreign scholars' research on this aspect, this paper summarizes the research progress of the palladium-catalyzed activation of aromatic ring C-H bonds in the past ten years.

    更新日期:2020-01-14
  • Novel synthesis of silica-coated magnetic nano-particles based on acidic ionic liquid, as a highly efficient catalyst for three component system leads to furans derivatives
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2020-01-14
    Moheb Shirzaei; Ebrahim Mollashahi; Malek Taher Maghsoodlou; Mojtaba Lashkari

    In this work, thiocarbohydrazide doped iron nanoparticles as a novel, green, heterogeneous, and inexpensive catalyst is reported. This catalyzed the three components reaction of dialkylacetylenedicarboxylate with aromatic aldehydes and aromatic amines to yield the corresponding furan derivatives EtOH. An indispensable part of green chemistry is to be able to recover and reuse catalysts without any notable drop in catalytic activity. The analysis of catalyst and application of that for the synthesis of title compounds in high yields reveal this property. The formation, size of the metal ions present in the material is confirmed by powdered X-ray diffraction (XRD), scanning electron microscopy (SEM), infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA).

    更新日期:2020-01-14
  • Advances in the Scaffolds fabrication techniques using biocompatible polymers and their biomedical application: A Technical and Statistical Review
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2020-01-13
    Adnan Haider; Sajjad Haider; Madhusudana Rao Kummara; Tahseen Kamal; Faiza Jan Iftikhar; Bushra Bano; Naeem Khan; Mohammad Amjid Afridi; Sung Soo Han; Ali Alrahlah; Rawaiz Khan

    With the advancement in tissue engineering, researchers are working hard on new techniques to fabricate more advanced scaffolds from biocompatible polymers with enhanced porosity, appropriate mechanical strength, diverse shapes and sizes for potential applications in biomedical field in general and tissue engineering in particular. These techniques include electrospinning, solution blow spinning, centrifugal spinning, particulate leaching (salt leaching), freeze-drying, lithography, self-assembly, phase separation, gas foaming, melt molding, 3-D printing, fiber mesh and solvent casting. In this article we have summarized the scaffold’s fabrication techniques from biocompatible polymers that are reported so far, the recent advances in these techniques, characterization of the physicochemical properties of scaffolds and their potential applications in the biomedical field and tissue engineering. The article will help both newcomers and experts working in the biomedical implant fabrication to not only find their desired information in one document but also understand the fabrication techniques and the parameters that control the success of biocompatible polymeric scaffolds. Furthermore, a static analysis of the work published in all forms on the most innovative techniques is also presented. The data is taken from Scopus, restricting the search to biomedical fields and tissue engineering.

    更新日期:2020-01-14
  • Synthesis and characterization of magnetite nanoparticles for photocatalysis of nitrobenzene
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-12-25
    Victor Alfredo Reyes Villegas; Jesús Isaías De León Ramírez; Esteban Hernandez Guevara; Sergio Perez Sicairos; Lilia Angelica Hurtado Ayala; Bertha Landeros Sanchez
    更新日期:2019-12-25
  • Magnetism and Application of NiFe@Au Nanoparticles
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-12-18
    Fengxia Gao; Yan Liu; Shiyao Shen
    更新日期:2019-12-18
  • Uracil-coumarin based hybrid molecules as potent anti-cancer and anti-bacterial agents
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-12-12
    Mohit Sanduja; Jyoti Gupta; Harbinder Singh; Piyusha P. Pagare; Abhineet Rana

    In the current report, we have rationally designed a series of uracil-coumarin based bifunctional molecular hybrids roped by 1,2,3-triazole moiety. The designed compounds were synthesized and tested against a panel of six human cancer cell lines namely Colo-205, MCF-7, A-549, PA-1, PC-3 and Hela cells by Sulforhodamine B assay. The results indicated that the hybrid molecules can specifically inhibit the MCF-7 cancer cell proliferation amongst which A-2 was found to be most potent hybrid (GI50 = 1.55 µM) with fluorine atom as R with two carbon chain length between triazole and coumarin moieties. Cell cycle analysis revealed that A-2 significantly arrest the G2/M phase to inhibit proliferation of MCF-7 cells. Due to its mitotic arrest, A-2 was further analyzed to predict its various binding interactions within the active site of tubulin, which revealed its best binding pattern within the colchicine binding site. In addition to this, antibacterial potential of all the synthetics was also evaluated which resulted in two hit lead molecules A-2 (MIC= 11.7 μg/ml) and A-3 (MIC= 7.23 μg/ml) that can significantly inhibit the bacterial strain Staphylococcus aureus comparable to that of standard drug levofloxacin (MIC= 3.12 μg/ml). Binding interactions within the active site of dihydrofolate reductase (DHFR) were also streamlined by using molecular docking studies. Overall studies revealed some interesting features of synthetics to be active which stated that, the compounds with electronegative atom on R and compounds with two carbon chain length between triazole and coumarin showed best results.

    更新日期:2019-12-13
  • Synthesis and in vitro anti-proliferative capabilities of steroidal thiazole and indole derivatives
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-05-16
    Fariha Shamim, Kanwal, Firdos Alam Khan, Muhammad Taha, Khalid Mohammed Khan, Arshia

    Derivatives (1–15) of steroidal and indole class were synthesized using different strategies. These compounds were characterized by 1H NMR spectroscopy and EI-MS, respectively. The synthetic derivatives were examined for their cytotoxic effects on human adenocarcinoma cells (HCT-116) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and morphometric analysis. The cytotoxic effects of all the compounds were observed after 48 h treatment and it was found that out of fifteen, four compounds 1, 2, 3, and 14 showed inhibitory action on the cancer cells. We have calculated the IC50 values for compounds 1, 2, 3, and 14 which were 22.50 µg/mL, 55.65 µg/mL, 21.35 µg/mL and 58.50 µg/mL, respectively. The compounds 3 (IC50 = 21.35 µg/mL) and 1 (IC50 = 22.50 µg/mL) showed highest inhibitory activities as compared to compounds 2 (IC50 = 55.65 µg/mL) and 14 (IC50 = 58.50 µg/mL). These results suggested that steroidal thiazole and indole derivatives are potent lead molecules having strong anti-cancer proliferative capabilities.

    更新日期:2019-12-11
  • Synthesis, structure, photophysical properties and biological activity of a cobalt(II) coordination complex with 4,4′-bipyridine and porphyrin chelating ligands
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-03-23
    Nesrine Amiri, Sahar Nouir, Melek Hajji, Thierry Roisnel, Taha Guerfel, Gérard Simonneaux, Habib Nasri

    A new bioactive material of cobalt(II) with 5,10,15,20-tetrakis[4 (benzoyloxy)phenyl] porphyrin (TPBP) and bpy ligands ([CoII(TPBP)(bpy)2] 1) has been synthesized and characterized by Single-crystal X-ray diffraction (SCXRD), spectroscopic methods and quantum-chemistry calculations. In the crystalline structures of six coordinated Co(II) [CoII(TPBP)(bpy)2] 1, linear 1D polymeric chains were observed in which all the porphyrin units are aligned parallel to each other. The crystal packing is stabilized by inter-and intramolecular C–H⋯O and C–H⋯N hydrogen bonds, and by weak C–H⋯Cg π interactions. Interestingly, NBO–Second-order perturbation theory analysis, carried out at the UB3LYP/6-31G(d)/SDD DFT level of theory, demonstrated that a two-center bond between the nitrogen atoms and the cobalt ions (Co) was not found, the Co–Npy/bp interactions are coming from an electronic delocalization between the Npy/Nbp filled orbitals to the anti-bonding LP*(4) and LP*(5) metal NBOs. Mass spectroscopy, and elemental analysis were also investigated to confirm the molecular structure. The downfield shift and the peak broadening of the axial ligand resonances observed in the 1H NMR indicated the contiguity to the paramagnetic Co(II) center. Additionally, the photophysical properties have been evaluated by UV–visible absorption, and fluorescence emission spectroscopies. Finally, bioactivity investigations revealed that free porphyrin TPBP, CoIITPBP and complex 1 could be used as potential antioxidant agents.

    更新日期:2019-12-11
  • Unsymmetrically substituted benzimidazolium based Silver(I)-N-heterocyclic carbene complexes: Synthesis, characterization and in vitro anticancer study against human breast cancer and colon cancer
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-03-23
    Aqsa Habib, Mansoureh Nazari V., Muhammad Adnan Iqbal, Haq Nawaz Bhatti, M.B. Khadeer Ahmed, A.M.S. Abdul Majid
    更新日期:2019-12-11
  • S8-mediated decarboxylative cyclization of 2-nitrophenols with arylacetic acid: Synthesis of benzoxazoles
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-03-21
    Haifeng Gan, Dalong Yang

    A concise, metal-free protocol has been established for the preparation of 2-arylbenzoxazoles from 2-nitrophenols and arylacetic acids via a sulfur-mediated redox decarboxylative cyclization reaction. The reactions proceeded in moderate to good yields, and gram-scale is suitable.

    更新日期:2019-12-11
  • Synthesis, characterization, electrochemical behavior and antioxidant activity of new copper(II) coordination compounds with curcumin derivatives
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-03-11
    Mirela Călinescu, Mălina Fiastru, Daniela Bala, Constantin Mihailciuc, Ticuţa Negreanu-Pîrjol, Bogdan Jurcă

    Five new copper(II) coordination compounds were prepared by template synthesis, using curcumin, 2-hydrazinobenzothiazole and metal salt (copper chloride, bromide, acetate and nitrate) in 1:2:1 and 1:2:2 molar ratio. The complexes were characterized by elemental and thermogravimetric analysis, IR, UV–Vis and mass spectroscopic methods and cyclic voltammetric studies. On the basis of physico-chemical measurements the following formulae have been assigned to the complexes: [Cu(H2L)(H2O)2]Cl2·H2O, [CuL]·H2O, [Cu(H2L)(H2O)Br]Br·5H2O, [Cu2L(H2O)4](NO3)2·2H2O and [Cu2(H2L)(NO3)4]·H2O, where H2L is the hydrazone ligand formed in the reaction conditions. Metal complexes were tested for antioxidant activity by photochemiluminescence and this activity was quantified by comparison with TROLOX®, as standard. The results show that all complexes are more potent antioxidant agents than curcumin.

    更新日期:2019-12-11
  • Facile, single-pot preparation of nanoporous SiO2 particles (carrier) with AgNPs at core and crust for controlled disinfectant release
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-03-11
    M. Salman Haider, Godlisten Shao, Ayyaz Ahmad, S. Muhammad Imran, Nadir Abbas, Ghulam Abbas, Manwar Hussain, Hee Taik Kim

    This study demonstrates a novel, facile and one-pot approach to synthesize silica nanoparticles with silver at core and crust (SiNP-AgCC). A modified Stöber method was used to make SiNP-AgCC. A significant reduction in the size of SiO2 nanoparticles was seen, with 2–5 nm AgNPs being uniformly distributed on the surface and 10–20 nm AgNPs in the center. A typical mesoporous SiO2 particle (SiNP) produced using the Stöber method was transformed to nanoporous SiO2 by this modified Stöber method. Nanoporous SiO2 particles with silver in the center are advantageous for slow and consistent Ag+ release, which was confirmed by Ag+ ion release test. Antibacterial activities of the samples were tested to evaluate the disinfection performance of the samples on gram-negative bacteria (Escherichia coli) using disk diffusion and the LB-agar method. SiNP-AgCC showed prolonged silver release for more than 20 days and improved antibacterial properties even after five days of incubation.

    更新日期:2019-12-11
  • In-situ oxidative polymerization of aniline on hydrothermally synthesized MoSe2 for enhanced photocatalytic degradation of organic dyes
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-02-26
    Honey Mittal, Arun Kumar, Manika Khanuja

    In this paper, we report synthesis of MoSe2-polyaniline by in-situ polymerization method. Simple and eco-friendly hydrothermal technique is used for the synthesis of MoSe2. Sample characterizations were done using Field Emission Scanning Electron Microscopy (FESEM), X-Ray Diffraction (XRD), UV–vis Spectroscopy, Fourier Transform Infra-Red Spectroscopy (FTIR) and Raman Spectroscopy. Photocatalytic dye degradation was performed using nanocomposite on Methylene blue (MB) and Methyl orange (MO). Photocatalytic degradation efficiency (ƞ) was found to be ∼65% and ∼94% for MB and MO, respectively. Reaction kinetics were studied and fitted well with pseudo first order model because of the mesoporous structure of polyaniline (PANI). Material reusability and regenerability was also checked for number of cycles.

    更新日期:2019-12-11
  • SBA‐15@ABA-M (M = Cu, Ni and Pd): Three efficient, novel and green catalysts for oxidative coupling of thiols under mild reaction conditions
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-02-23
    Taiebeh Tamoradi, Mohammad Ghadermazi, Arash Ghorbani-Choghamarani

    In the present study, oxidative coupling of thiols was carried out using immobilized Cu, Ni and Pd complexes on SBA-15 mesostructured as novel and green heterogeneous catalysts under mild reaction conditions. These supported complexes were characterized by FT-IR, XRD, TEM, TGA, EDX, ICP and BET techniques. These nanohybrid robust catalysts have outstanding advantages such as facile synthesis, use of green medium, high surface area, easy separation and workup, excellent reused for several consecutive cycles without noticeable change in its catalytic activity, and short reaction time.

    更新日期:2019-12-11
  • The preparation and properties of polyimide films modified by octa(aminopropylsilsesquioxane)
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-02-22
    Benbo Liu, Bin Zhang, Xumeng Wang, Xuanying Chen, Guangxin Gu

    A number of polyimide films incorporated with different amounts of octa(aminopropylsilsesquioxane) (POSS-NH2) were prepared from 1,2,4,5-Benzenetetracarboxylic anhydride, 4,4′-Oxydianiline and POSS-NH2. The structure and properties of the hybrid polyimide films were characterized and evaluated. It is found that, compared with pure polyimide without POSS-NH2, the thermal stabilities and electrical capabilities of hybrid polyimide films are improved. Meanwhile, the incorporation of POSS-NH2 also brings improvement in the flexibility of polyimide films.

    更新日期:2019-12-11
  • Green synthesis and application of nanoscale zero-valent iron/rectorite composite material for P-chlorophenol degradation via heterogeneous Fenton reaction
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-02-14
    Teng Bao, Jie Jin, Mekdimu Mezemir Damtie, Ke Wu, Zhi Ming Yu, Lie Wang, Jun Chen, Yong Zhang, Ray L. Frost

    A zero-valent iron/rectorite nanocomposite (NZVI/rectorite) was developed as a heterogeneous H2O2 catalyst for P-chlorophenol degradation. The physicochemical properties of NZVI/rectorite were characterized by various techniques including X-ray diffraction, scanning electron microscopy, transmission electron microscopy, energy-dispersive spectrometry, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and Brunauer–Emmett–Teller analysis. Results showed that NZVI sphere nanoparticles were successfully loaded on the rectorite surface with less aggregation and good dispersion. Moreover, compared with acid-leached rectorite (30.91 m2/g), the NZVI/rectorite appeared to have larger surface area (50.75 m2/g). In addition, the effects of pH, reaction time, initial P-chlorophenol concentration, catalyst amount, and H2O2 dosage on the P-chlorophenol degradation were systematically investigated. Results showed that NZVI/rectorite presents better properties for the degradation and mineralization of P-chlorophenol compared with pristine NZVI due to the large surface area, low aggregation, and good dispersion of the former. The degradation mechanisms of P-chlorophenol by NZVI/rectorite were adsorption and reduction coupled with a Fenton-like reaction. Four successive runs of the stability and regeneration study also showed that the NZVI/rectorite were unchanged even after 100% of P-chlorophenol degradation ratio. This study has extended the application of NZVI/rectorite as environment function material for the removal of P-chlorophenol from the environment.

    更新日期:2019-12-11
  • Synthesis of polyglycolic acid copolymers from cationic copolymerization of C1 feedstocks and long chain epoxides
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-02-11
    Yusuf Reyhanoglu, Ersen Gokturk

    Polyglycolic acid (PGA), which is an important biodegradable polymer, can traditionally be synthesized through the ring opening polymerization of glycolide (with mostly using tin octanoate catalyst). Our previous studies revealed that PGA was alternatively synthesized with one-step cationic polymerization of formaldehyde from trioxane and carbonmonoxide (CO), sustainable C1 feedstocks obtainable from biomethanol or biogas. PGA and its copolymers can be mainly used for the biomedical applications due to their biocompatibility and biodegradability. In order to utilize PGA in other marketing materials such as packaging, PGA should be specifically engineered to improve its physical properties by a copolymerization strategy utilizing appropriate comonomers since PGA displays brown or beige color and is not soluble in most organic solvents due to its very high crystallinity. In this study; to improve on the physical properties of PGA, such as melting temperature and solubility, polymerizations of trioxane, CO and a minor amount of epoxides with long side chains were performed under the same reaction condition as PGA homopolymer synthesis (DCM solvent, at 800 psi, with triflic acid catalyst, reaction time of 72 h). The results have shown that optimum polymerizations were achieved at lower reaction temperatures than that of PGA homopolymer synthesis (110 °C versus 170 °C). The melting temperatures of all copolymers are lower, and the colors of the copolymers have become lighter than that of PGA homopolymer. The solubilities of obtained copolymers also increased by increasing side chain length of epoxides in the polymer backbone.

    更新日期:2019-12-11
  • Highly sensitive SERS monitoring of catalytic reaction by bifunctional Ag-Pd triangular nanoplates
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-02-10
    Jie Yang, Xin-Yue Wang, Ling Zhou, Fan Lu, Ning Cai, Ju-Mei Li

    Surface-enhanced Raman spectroscopy (SERS) can attain the “fingerprint” information of molecules from their vibrational transitions for detecting chemical species and thus displays extraordinary application value in studying chemical reaction mechanism catalyzed by noble metal nanoparticles in recent years. Herein, we successfully fabricated bifunctional Ag-Pd triangular nanoplates with integration of catalytic and SERS activities, using Ag triangular nanoplates as templates and Na2PdCl4 as Pd precursor in the presence of ascorbic acid acting as reducing agent and polyvinylpyrrolidone serving as stabilizing agent. We found slowly titrating Na2PdCl4 solution, compared with the one-shot injection during reaction, can strongly restrain the galvanic replacement reaction and maintain the Ag content, therefore retaining the plasmonic and SERS properties of Ag-Pd triangular nanoplates. By easily adjusting the amount of Na2PdCl4, we can optimize the SERS and catalytic activities of Ag-Pd triangular nanoplates. The optimal Ag-Pd triangular nanoplates with dual functionalities are used to follow the catalytic reduction process of 4-nitrothiophenol in the presence of NaBH4 by SERS. The results reveal 4-nitrothiophenol is directly transformed to 4-aminothiophenol through a one-step route. Thereby, the prepared Ag-Pd triangular nanoplates are effective and suitable for sensitively investigating the catalytic reaction process by in situ SERS.

    更新日期:2019-12-11
  • Metal- and acid-free, TBN-mediated direct CH nitration of arenes
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-01-18
    Guangqiang Xu, Li Zhou, Chengdong Lv, Mo Xian, Qinggang Wang
    更新日期:2019-12-11
  • Spectroscopic and biological properties of platinum complexes derived from 2-pyridyl Schiff bases
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-03-23
    Nada D. Al-Khathami, Kamelah S. Al-Rashdi, Bandar A. Babgi, Mostafa A. Hussien, Muhammad Nadeem Arshad, Naser E. Eltayeb, Sobhy E. Elsilk, Jamal Lasri, Amal S. Basaleh, Mutlaq Al-Jahdali

    The reactions of a range of aromatic primary amines with pyridine-2-carboxaldehyde were reported, highlighting the effect of the substituents of the amine on the outcomes of the Schiff base reactions. The variant products of the Schiff base reactions were reacted with cis-[PtCl2(DMSO)2], generating platinum(II) complexes with PtCl2(N^N) general formula. The ligands and platinum(II) complexes were identified and characterized by IR and NMR spectroscopic methods. Single crystal XRD offered structural confirmation for three of the organic compounds and two platinum complexes. The spectral, antimicrobial, DNA-binding and molecular docking of the platinum complexes were studied, highlighting the effect of the different functional group in the Schiff base ligands on their properties. In general, introducing the electron-withdrawing group nitro or acetyl in the 2-pyridyl Schiff base ligands, results in a red-shift in the absorption maxima of the platinum complex. In addition, the enhancement in the antimicrobial activities and the increase in the ct-DNA-binding affinity were also observed when the nitro or acetyl functional group is introduced to the Schiff base ligand in the platinum(II) complex.

    更新日期:2019-12-11
  • Steam reforming of toluene as model of tar compound over Mo catalysts derived from hydrotalcites
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-04-13
    Gheorghiţa Mitran, Daniel G. Mieritz, Dong-Kyun Seo

    This study evaluated the catalytic activity of Mo catalysts derived from hydrotalcite-like compounds for steam reforming of toluene as a model compound for tar. The catalysts with 1.5, 3 and 4.5 Mo loadings (wt%), denoted as Mo1.5MgAl, Mo3MgAl and Mo4.5MgAl respectively, were prepared by coprecipitation and characterized by BET, XRD, SEM, TEM, FT-IR and UV–VIS. The results showed that toluene conversion increased with increasing molybdenum content. The hydrogen amount depended on two factors: the presence of molybdate species on the surface and the presence of aluminum cations in tetrahedral sites (Mo3MgAl), with molybdenum influence being more pronounced. The H2/CO ratio decreased at increasing temperature while, the H2/CO2 ratio increased proportionally with temperature. Mo1.5MgAl catalyst was more selective for CO2 and H2, while, Mo3MgAl and Mo4.5MgAl were more selective for CO and H2.

    更新日期:2019-12-11
  • Methodologies for the synthesis of pentacene and its derivatives
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-04-13
    Rohit Bhatia, Durgesh Wadhawa, Gargi Gurtu, Jitender Gaur, Deepak Gupta

    In recent years, due to its high hole-mobility, high on/off current ratio and low threshold voltage, pentacene and its derivatives have found increasing application in the fabrication of light-emitting diodes, field-effect transistors and photovoltaic cells. It has also emerged as an alternative to silicon due to its similar performance to inorganic semiconductors. Pentacene cannot be isolated from the petroleum fractions like other acenes such as anthracene or tetracene, and therefore it needs to be chemically synthesized. The first successful synthesis of pentacene was reported in early 19th century where pentacene was obtained via dehydrogenation of 6,14-dihydropentacene. Since then a number of methods have been reported for the synthesis of pentacene. This review describes various strategies used for the synthesis of pentacene and its derivatives reported since 2005.

    更新日期:2019-12-11
  • Selective conversion of furfuryl alcohol to 2-methylfuran over nanosilica supported Au:Pd bimetallic catalysts at room temperature
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-05-06
    Obaid Fahad Aldosari

    Using gold and palladium supported catalysts, the selective hydrogenation of furfuryl alcohol into 2-methylfuran at 25 °C was examined. The use of 2-methylfuran has become applicable in the perfumery and personalised care product industry, and it has been shown that there are two conditions under which Au:Pd/SiO2 catalysts are successful for selectivity to 2-methylfuran at 25 °C and (1 bar, H2). Moreover, this study has shed light on the effectiveness of several reaction conditions (supports and catalyst amount).

    更新日期:2019-12-11
  • Synthesis, spectral characterization, molecular docking studies, biological activity of (E)-2-((E)-3-(3,4,5-trimethoxyphenyl)allylidene) and (E)-N-phenyl 2-((E)-3-(3,4,5-trimethoxyphenyl)allylidene)hydrazinecarbothioamides and their Cu(II) complexes
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-04-29
    A. Sreenath Reddy, Jincheng Mao, S. Vanitha, Vishnu Nayak Badavath, L. Sivarama Krishna, M. Lavanya, M.V. Jyothi kumar

    Two slightly distorted octahedral complexes of copper(II) with (E)-2-((E)-3-(3,4,5-trimethoxyphenyl)allylidene)hydrazinecarbothioamide (L1) common name 3,4,5-trimethoxy-cinnamaldehydethiosemicarbazone and (E)-N-phenyl-2-((E)-3-(3,4,5-trimethoxyphenyl)-allylidene)hydrazinecarbothioamide (L2) common name 3,4,5-trimethoxycinnamaldehyde-4-phenylthiosemicarbazone have been synthesized. The two free ligands and their copper(II) complexes were characterized by spectroscopic techniques like FT-IR, FT-Raman, UV, EPR, Powder X-ray diffraction and cyclic voltammetry. The EPR spectra evidenced a rhombically distorted octahedron geometry for both the copper(II) complexes. The band gap calculations for the ligands L1, L2 and their complexes Cu(L1)2Cl2 and Cu(L2)2Cl2 were found to be 2.98, 2.61, 2.66 and 2.50 eV respectively. Cu(L1)2Cl2 and Cu(L2)2Cl2 have shown 50% of viability at 80 μg/ml and 60 μg/ml. The anti-oxidant activity study revealed that the compounds are good reductants of DPPH radical. Moderate to good anti-bacterial activity is shown by the compounds against the Gram-positive and Gram-negative bacteria. Molecular docking studies have been carried out to predict the orientation and binding mode of analysis in the active site. The synthesized ligand and complex well occupy (catalytic triad and adenine-binding site) in the active site of β-ketoacyl-acyl carrier protein synthase III enzyme, and also well occupy in helix 11 (in the DCS complex) of human estrogen receptor. Moreover they form water mediated hydrogen bond and hydrogen bond with Cys530 residue.

    更新日期:2019-12-11
  • Mesopore-dominant porous carbon derived from bio-tars as an electrode material for high-performance supercapacitors
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-05-06
    Mi-Mi Wei, Wen-Ping Li, Jie Weng, Yun-Quan Liu, Shui-Rong Li, Yue-Yuan Ye, Meng Wang, Duo Wang

    For the first time, toxic bio-tars collected from the gasification of pine sawdust are used as the precursor for activated carbons. Various types of activation agents including KOH, K2CO3, H3PO4 and ZnCl2 were screened for obtaining superior activated carbons. When KOH was used as an activation agent, the obtained activated carbons exhibited high specific surface area and large mesopore volume. The activated carbons were further employed to be the electrode material of supercapacitors, and its specific capacitance reached up to 260 F g−1 at 0.25 A g−1 current density. Also, it showed an excellent rate performance from preserving a relatively high specific capacitance of 151 F g−1 at 50 A g−1. The assembled device also exhibited the good electrochemical stability with the capacity retention of 90% after 5000 cycles. Furthermore, the maximum energy density of the activated carbons in organic electrolyte reached 17.8 Wh kg−1.

    更新日期:2019-12-11
  • Iron-catalyzed synthesis of phenanthrenes via intramolecular hydroarylation of arene-alkynes
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-05-16
    Yang Li, Yawei Li, Xiao Hu, Guangxing Pan, Wangsheng Liu, Yaopeng Zhang, Hao Guo

    An Fe(OTf)3-catalyzed intramolecular hydroarylation of arene-alkynes with high functional group tolerance has been reported, affording a series of phenanthrene derivatives efficiently. A low catalytic amount of Fe(OTf)3 is applied in this reaction. This transformation provides a convenient and practical method for the preparation of phenanthrenes.

    更新日期:2019-12-11
  • Starch nanoparticles as a bio-nanocatalyst in synthesis of diheteroaryl thioethers
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-05-16
    Homeyra Rostami Monjezi, Zohre Zarnegar, Javad Safari

    Nanostarch is shown to be a highly efficient, eco-friendly and heterogenous organocatalyst for the synthesis of the diheteroaryl thioethers via one-pot reaction of methylcarbonyls, thiourea and iodine in DMSO. This method offers significant advantages such as available starting materials, higher purity and excellent yield of products, very easy reaction conditions and absence of any tedious purification. Furthermore, because of employing eco-friendly catalyst without using transition metal catalysts, this novel method emerges as a green-approach leading to less harmful residues. Moreover, a mechanism was proposed to rationalize the reaction and the role of starch nanoparticles was also investigated in these transformations.

    更新日期:2019-12-11
  • CuSO4/sodium ascorbate catalysed synthesis of benzosuberone and 1,2,3-triazole conjugates: Design, synthesis and in vitro anti-proliferative activity
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-05-11
    CH.B. Praveena Devi, K. Vijay, B. Hari Babu, Syed Farooq Adil, M. Mujahid Alam, M. Vijjulatha, Mohd. Bismillah Ansari

    A novel series of conjugates of benzosuberone and 1,2,3-triazole i.e. 3-(4-phenyl-1H-1,2,3-triazol-1-yl)propyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzo[7]annulene-8-carboxylic acids (8a-j) were synthesized in good to excellent yields catalysed by CuSO4 under milder reaction conditions and evaluated for their anti-proliferative activity. The structural elucidation of the prepared compounds was carried out using IR, 1H NMR, 13C NMR and Mass spectral analysis. The newly synthesized derivatives (8a-j) were evaluated for their anti-proliferative activity against four human cell lines and the novel derivatives showed moderate to excellent activity. The obtained results suggest that these compounds can be considered as new hits for anti-proliferative drug development programme and further SAR studies can help obtain better anticancer agents.

    更新日期:2019-12-11
  • Synthesis of high-solid, low-viscosity hydroxy acrylic resin modified with TBCHA
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-05-11
    Xumeng Wang, Qunjie Xu, Haikun Yu, Jie Xu

    Hydroxyl acrylic resin using 4-tert-Butylcyclohexyl acrylate (TBCHA) as functional monomer has been synthesized via solution polymerization technique. Most critical experimental conditions have been optimized first by mixture experimental design methodology prior to real experiment operations. Afterward high-solid and low-viscosity hydroxy acrylic resin was synthesized under the optimized experimental conditions. According to a series of characterization methods including rheology, IR, TGA, addition of functional monomer, TBCHA, combined with optimized experiment conditions can reduce the viscosity of as-synthesized resin significantly at high solid content.

    更新日期:2019-12-11
  • Effects of pyrolysis temperatures on the textural, magnetic, morphology, and catalytic properties of supported nickel nanoparticles
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-06-28
    Ahmad Alshammari, Naif Alarifi, Marzook Alshammari, Manzar Sohail, Rashid Altamimi

    The development of base metal catalysts for industrially important reactions continues to be an important goal of catalysis research. Herein, the effects of pyrolysis temperature on the textural, structural, surface, magnetics properties and catalytic properties of silica-supported nickel nanoparticles (NiNPs) were thoroughly investigated. Mono-dispersed NiNPs encapsulated in graphitic shells were first successfully obtained and were characterized using a variety of methods such as BET surface area measurement, CO-pulse chemisorption, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), high resolution transmission electron microscopy (HR-TEM), and superconducting quantum interference device (SQUID) measurement. The findings showed that all catalysts’ properties were considerably altered with change in pyrolysis temperature. Hydrogenation of diphenylacetylene was then selected as the model reaction for the evaluation of the catalytic performance of the graphitic-shelled NiNPs. After testing, pyrolysis of a nickel at 800 °C (catalyst A) displayed tremendous activity and selectivity to produce >94% of stilbene with selectivities of 99% for the Z-isomer.

    更新日期:2019-12-11
  • Remediation of Azo-dyes based toxicity by agro-waste cotton boll peels mediated palladium nanoparticles
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-12-10
    Boya Palajonnala Narasaiah, Badal Kumar Mandal

    The present study reports an environmental benign route for the synthesis of palladium nanoparticles (Pd NPs) using agro-waste empty cotton boll peels aqueous extract for the first time. Surface Plasmon Resonance (SRP) band in absorption spectrum of Pd NPs at 275 nm confirmed the formation of Pd NPs by using UV-Vis spectroscopy. Crystalline nature of Pd NPs was confirmed by powder XRD analysis. Size and morphology was studied by transmission electron microscopy (TEM). The cotton peels extract acted as a source of phytochemicals which primarily reduced Pd+2 to Pd0 nanoparticles (Pd NPs) and imparted stability of Pd NPs by surface capping. The characteristic functional groups of phytochemicals in extract and capped Pd NPs surfaces were identified by FT-IR analysis. Catalytic activity of the synthesised Pd NPs was checked against degradation of hazardous azo-dyes such as Congo red, Methyl orange, Sunset yellow and Tartrazine with NaBH4 as electron donors. Pd NPs catalysed reduction of all azo-dyes by NaBH4 in aqueous medium was monitored by UV-visible spectroscopy where Pd NPs mediated transfer of electrons from NaBH4 to azo-dyes as carrier. The synthesized Pd NPs acted as a good catalyst and could be a promising material in degrading toxic azo-dyes from industrial effluents and wastewater.

    更新日期:2019-12-11
  • Facile synthesis of palladium nanoparticles supported on urea-based porous organic polymers and its catalytic properties in Suzuki-Miyaura coupling
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-11-30
    Pengwei Gao, Yongmei Xiao, Zhenhua Dong, Hongguo Pan, Wentao Wang

    By using urea linked porous organic polymers as template, a new nano palladium catalyst with low Pd loading can be easily prepared (1.0 wt% Pd only). Although such less amount of Pd was contained in this new catalyst, it is still an effective catalyst for the Suzuki-Miyaura coupling of aryl iodines and aryl boric acids, affording biphenyl products in excellent yields with outstandingly enhanced turnover numbers (up to 10,536) under green solvent (water).

    更新日期:2019-12-11
  • Synthesis and characterization of CuFe2O4/NiMgAl-LDH composite for the efficient removal of oxytetracycline antibiotic
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-11-20
    Jamiu O. Eniola, Rajeev Kumar, Olfat A. Mohamed, A.A. Al-Rashdi, M.A. Barakat

    In this study, a modified copper ferrite/NiMgAl layered double hydroxide (CuFe2O4/NiMgAl-LDH) composite was developed for the adsorptive removal of oxytetracycline hydrochloride (OTC) antibiotic from aqueous solution. Material characterization by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transforms infrared spectrum (FTIR) and X-ray photoelectron spectroscopy (XPS) confirms that the resultant material composes of a hexagonal layered doubled hydroxide structure with surficial deposits on CuFe2O4 cubes. The adsorption of OTC onto the prepared materials were studied as a function of solution pH, initial OTC concentration, reaction time and temperature. The OTC adsorption capacities of the prepared materials were as follows: CuFe2O4/NiMgAl-LDH composite > NiMgAl-LDH > CuFe2O4. The adsorption of OTC in the presence of salts like CuSO4, NaHCO3, NaCl were also studied and the results revealed that CuSO4 has a positive effect on OTC adsorption while NaHCO3 and NaCl showed the neutral and antagonistic effect. The results revealed that hydrogen bonding, anionic exchange, and electrostatic forces were mainly involved in the adsorption of OTC onto CuFe2O4/NiMgAl-LDH composite. OTC adsorption followed the pseudo-second-order kinetic model while the adsorption equilibrium data were well fitted to the Langmuir isotherm model with the maximum adsorption capacity of 192 mg/g at 323K. Furthermore, the thermodynamic study revealed that the adsorption process was spontaneous and endothermic.

    更新日期:2019-12-11
  • Integration of naturally bioactive thiazolium and 1,3,4-oxadiazole fragments in a single molecular architecture as prospective antimicrobial surrogates
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-11-11
    Huai-He Zhu, Dan Zeng, Ming-Wei Wang, Pei-Yi Wang, Yuan-Yuan Wu, Li-Wei Liu, Song Yang

    Plant microbial diseases caused global production constraints have become one of the most challenging events, thus urgently needing to be addressed nowadays. To efficiently promote the discovery of promising antimicrobial surrogates, a type of 1,3,4-oxadiazole thioethers owning naturally bioactive thiazolium patterns was designed and fabricated. Antibacterial screening results revealed that title compounds could significantly inhibit the growth of pathogens Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri. And the related antibacterial efficacy was elevated by approximately 386-, 16-, and 24-folds comparing those of mainly used commercial agents bismerthiazol and thiodiazole copper. In vivo experiment suggested that A9 could manage rice bacterial blight with the corresponding curative and protection efficiencies of 48.01% and 50.55% at 200 μg/mL. Moreover, SEM patterns and fluorescence spectra were performed to explore the possible antibacterial mechanism. Preliminary antifungal bioassays revealed that these molecules paraded broad-spectrum inhibition effects against three tested fungal strains. Considering the simple molecular skeleton and significant biological actions, title compounds can be further explored as potential antimicrobial surrogates for managing plant bacterial and fungal diseases.

    更新日期:2019-12-11
  • Microwave-promoted solvent-free synthesis of para-quinone methides (p-QMs) derivatives
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-11-06
    Zhang-Qin Liu, Peng-Sheng You, Chuan-Hua Wu, Yang-Hong Han

    A rapid and efficient methodology for the synthesis of polysubstituted para-quinone methides (p-QMs) from aldehyde and 2,6-di-tert-butylphenol has been achieved in solvent-free and microwave irradiation condition within 33 min. This strategy displays the advantages including high atom economy, good functional group tolerance, and environmentally friendly operation.

    更新日期:2019-12-11
  • 更新日期:2019-12-11
  • Lightweight excellent microwave absorption properties based on sulfur doped graphene
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-09-25
    Lin Tan, Menghui Zhu, Xiaoyang Li, Huixia Feng, Nali Chen, Dan Zhao
    更新日期:2019-12-11
  • Application of silicon dioxide nanoparticles modified with tumor-targeting ligands for cellular delivery of nucleoside triphosphate analogues
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-09-24
    Svetlana V. Vasilyeva, Albina S. Petrova, Alexander A. Shtil, Dmitry A. Stetsenko

    A key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery. To improve the efficacy for intracellular delivery, SiO2 nanoparticles were functionalized with tumor-targeting ligands folic acid, biotin or 5-fluorouracil. Studies of accumulation of these conjugates in HCT116 colon carcinoma cells revealed that the uptake of modified conjugates was significantly bigger compared to unmodified nanoparticles, with the biotinylated conjugate as the preferred compound. The nanocomposites of biotin modified SiO2 and 2′,3′-dideoxyuridine triphosphate showed a pronounced antiproliferative potency relative to the unmodified nanocomposites. Thus, multi-functionalization of SiO2 nanoparticle based conjugates has a major potential for delivery of nucleoside triphosphate analogues, therefore tentatively enhancing their bioactivity.

    更新日期:2019-12-11
  • Facile CuCl2·2H2O catalyzed one-pot conversion of dimedone into highly functionalized indazole based N-arylhydrazinecarbothioamides
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-09-17
    Rafaila Rafique, Syed Muhammad Saad, Arshia, Khalid Mohammed Khan, Shahnaz Perveen, Muhammad Taha

    A convenient and facile CuCl2·2H2O catalyzed one-pot synthetic strategy was designed for the conversion of readily available dimedone into highly functionalized N-arylhydrazinecarbothioamide based indazole derivatives. The product yields were found to be moderate to good without purification requirements. Structural features of the synthetic compounds were confirmed by various spectroscopic techniques such as 1H NMR, 13C NMR, EI-MS, FAB-MS, HREI-MS, and HRFAB-MS. The reaction intermediates were also quenched and characterized. Plausible reaction mechanisms were also discussed.

    更新日期:2019-12-11
  • Synthesis of montmorillonite-based tris(2-ethylamine)-Schiff-base composites with remarkable antibacterial activity
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-09-17
    El-Refaie Kenawy, Mohamed R. Berber, Khalil Saad-Allah, Mohamed Azaam

    A range of heterogeneous, inexpensive and benign Schiff bases-montmorillonite composites were synthesized and screened for their antibacterial activity against common microbial pathogens. Sodium montmorillonite (Na-MMT) clay was modified with tris(2-ethylamine) in the presence of dilute HCl to yield a quaternary salt of tris(2-ethylamine) modified clay. The Schiff bases were then fabricated from the reaction of the modified montmorillonite using different aldehydes. The structures of the obtained compounds were confirmed by Fourier transformer Infrared (FT-IR), X-ray diffraction (XRD), and thermal gravimetric analysis (TGA). All the obtained composite materials were screened for their antibacterial activities against the multi-drug resistant (MDR) strains. It was reasoned that the modified MMT-based composites has the ability to absorb the different micro-organisms onto the surface, and accordingly act as an effective antibacterial agent. All the composites showed significant antibacterial activity between 2.5 and 20 mg/mL against the MDR bacterial strains. The benzyl-based/modified MMT and the tertiary amino-based/modified MMT was found to be the most effective antibacterial agent.

    更新日期:2019-12-11
  • Chemical and pharmacological aspects of novel hetero MLB complexes derived from NO2 type Schiff base and N2 type 1,10-phenanthroline ligands
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-09-17
    Somasundaram Hemalatha, Jeyaprakash Dharmaraja, Sutha Shobana, Paramasivam Subbaraj, Thirugnanasamy Esakkidurai, Natarajan Raman

    A series of hetero ligand MLB complexes (1–5) were synthesised from tridentate NO2 type Schiff base [H2L: (E)-2-((2-hydroxy-4-methoxyphenyl)(phenyl)methyleneamino)benzoic acid; derived from 2-hydroxy-4-methoxybenzophenone and 2-aminobenzoic acid] and bidentate N2 type 1,10-phenanthroline (B: phen) ligands. The structural characterization of the synthesised MLB complexes were carried out via analytical as well as various spectral studies. Additionally, the low molar conductance values (Λm = 14–22 Ω−1 cm2 mol−1) imply that the complexes (1–5) are non-electrolytes. The obtained results reinforce that stoichiometry of the mononuclear hetero ligand complexes can be represented as [M(II)-Schiff base(L)-phen(B)·H2O] and both H2L and (B) ligands can act as tri and bidentates respectively. Moreover, both the ligands bind with metal(II) ions to build a stable six, six, five membered chelate rings with octahedral geometry. The existing solvent water molecule is confirmed from thermal as well as vibrational analysis. Their microcrystalline nature and uniform surface morphology were confirmed by both powder XRD and SEM studies. 3D molecular modeling and analysis of NiLB and CuLB complexes (3 and 4) were also studied. Mn(II), Ni(II) and Cu(II) complexes (1, 3 and 4) strongly interact with DNA through intercalation binding with strong binding constant values. The obtained Kapp values were 5.23, 4.98, 6.36, 7.21 and 4.86 × 105 mol−1 for MLB complexes (1–5) respectively and the negative Δ‡G values shown that all the complexes are strongly interact with DNA in a spontaneous manner. Further, remarkable biological, antioxidant and DNA activities were remarkably exhibited by MnLB, NiLB and CuLB complexes.

    更新日期:2019-12-11
  • Synthesis, crystal structure, photoluminescence properties of organic-inorganic hybrid materials based on ethylenediamine bromide
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-09-12
    Wenhui Mao, Jilin Wang, Xinru Hu, Bing Zhou, Guoyuan Zheng, Shuyi Mo, Songbo Li, Fei Long, Zhengguang Zou

    In this work, a new orthorhombic organic-inorganic hybrid single crystal (C2H10N2)2MnBr4.2Br with-Zero-dimensional structure was synthesized by slow evaporation method at 75 °C. The crystal structure and intermolecular interactions were performed by single crystal X-ray diffraction and Hirshfeld surface. Optical properties of (C2H10N2)2MnBr4.2Br were systematically studied by Raman, infrared spectrum, UV–vis, photoexcitation spectra, and photoluminescence spectra. The optical band gap (Eg = 2.61 eV) were calculated from the absorption spectra of (C2H10N2)2MnBr4.2Br. This hybrid materials also had shown good thermal stability (decomposition temperature: 288–660 °C). Finally, photoluminescence measurements showed a strong excitation line at 362 nm and a strong fluorescence at 537 nm which makes it a promising material in luminescence field.

    更新日期:2019-12-11
  • Morphology effect of ZnO support on the performance of Cu toward methanol production from CO2 hydrogenation
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-09-12
    Guangyu Shi, Qing Chen, Qiuhong Zhang, Weijie Cai, Zhongcheng Li, Shangru Zhai, Hao Yu, Fengzhi Tan, Yuanhao Wang

    Recently, the chemical conversion of the greenhouse gas CO2 into value-added methanol has been of great interest. To address this issue, ZnO nanorods were synthesized by a facile microwave assisted technique and selected as support in Cu/ZnO catalyst. Herein, structure-activity relationship of the as-prepared catalysts in CO2 hydrogenation to methanol were elucidated in detail using different characterization technique including N2 physisorption, XRD, TPR, TEM, XPS and insitu DRIFTS (CO chemisorption) etc. Interestingly, rodlike ZnO hosted the highly dispersed Cu species, stronger Cu-support interaction at the interface in comparison with another reference CuZn-C sample, which was supported on commercial ZnO. In particular, EPR and XPS analysis evidenced the direct electron transfer from ZnO support to Cu species in CuZn-R, thereby facilitating the formation of O vacancies. These positive factors could provide the extremely active sites for CO2 hydrogenation and be correlated to the better catalytic activity. Indeed, the calculated TOFmethanol for CuZn-R was approximately ten times larger than that of CuZn-C sample. The results implied that the morphology structure of ZnO support, which could induce various crystal planes and amounts of defects and/or imperfections, possessed a critical role on the catalytic performance. This finding might shed light on the design of efficient catalysts for catalytic conversion of the undesirable CO2.

    更新日期:2019-12-11
  • 更新日期:2019-12-11
  • Highly ordered combined structure of anodic TiO2 nanotubes and TiO2 nanoparticles prepared by a novel route for dye-sensitized solar cells
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-09-05
    Tayyaba Ghani, Mohammad Mujahid, Mazhar Mehmood, Gengmin Zhang, Sumaira Naz

    Combined structure of anodic TiO2 nanotubes and TiO2 nanoparticles (TiNTs-TiNPs) has been synthesized by a facile combination of hydrothermal and chemical vapor deposition methods. Ordered TiO2 nanotubes with smooth walls were fabricated by two step anodization method in ethylene glycol containing NH4F at 50 V. This nanotubular array after annealing at 450 °C was subjected to the hydrothermally produced gaseous environment in an autoclave with diluted TiCl4 solution at its bottom. Vapors of TiCl4 were allowed to react chemically with water vapors for predefined time durations at 180 °C that resulted in the deposition of TiO2 nanoparticles on tubes’ surface and side walls. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) confirmed that for one hour reaction duration, nanoparticles were evenly coated on the walls of nanotubes, whereas, longer durations tend to deteriorate the tubular structure. Consequently, the ordered TiNTs-TiNPs array produced after one hour coating has shown better performance for dye-sensitized solar cell DSSC) in back illumination mode with 130% increase in efficiency as compared to the device based on bare TiO2 nanotubes. The same photoanode has higher reflective properties with higher scattering ability. The solar cell based on this photoanode exhibits higher external quantum efficiency and effective charge transport properties. This study shows that porous ordered 1D structures based on TiO2 are of crucial importance for the high performance of DSSCs.

    更新日期:2019-12-11
  • Mesoporous silica-supported V-substituted heteropoly acid for efficient selective conversion of glycerol to formic acid
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-09-05
    Ding-Jier Yuan, Jingling Yang, Amol M. Hengne, Yi-Tzu Lin, Chung-Yuan Mou, Kuo-Wei Huang

    V-substituted polymolybdenum phosphoric acid (PVxMo) supported on mesoporous silica was prepared and investigated as a catalyst for the oxidation of glycerol to formic acid in a batch operation. Different synthetic methods for PVxMo supported on mesoporous silica were compared. Detailed characterizations of the final products were carried out by N2 adsorption and desorption, XRD, HR-TEM, SEM, ICP-OES, XANES, NH3-TPD, and FTIR to identify the chemical properties and the porous structure of silica-supported PVxMo, as well as the strong interactions between PVxMo with the silica skeleton. These critical properties explain the bifunctionality of silica-supported PVxMo as a catalyst for the selective oxidation of glycerol to formic acid with standing stability.

    更新日期:2019-12-11
  • Carbon-supported binary Li-Sn catalyst for acetylene hydrochlorination
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-08-19
    Yibo Wu, Fuxiang Li, Zhiping Lv, Jianwei Xue

    The study of a novel catalyst containing LiCl and SnCl2 (LiSn/AC) for acetylene hydrochlorination has been reported in this paper. Furthermore, the performance of both high activity (98.3%) and selectivity (>98.0%) are achieved by LiSn/AC catalysts under the reaction temperature of 200 °C and C2H2 hourly space velocity of 30 h−1. The structural characteristics of the Sn based catalysts were deeply researched via BET, XRD, TEM, TPR, C2H2-TPD, XPS and TG techniques. According to these characteristic results, we proposed that the presence of Sn2+ exhibited better activity and stability than that of Sn4+ in Sn based catalysts. Additionally, LiCl additives not only can restrain the oxidation of Sn2+ and the loss of Sn4+ in fresh Sn based catalysts but also make the Snδ+ (δ = 2,4) species dispersed well on the surface of support. Therefore, the adsorption capacity of C2H2 and HCl was enhanced in LiSn/AC, which exhibited the better catalytic performance than that of Sn based catalyst.

    更新日期:2019-12-11
  • Synthesis, physico-chemical studies and biological evaluation of new metal complexes with some pyrazolone derivatives
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-08-16
    Ahmed M. Ramadan, Asma A. Alshehri, Samir Bondock

    A series of N-substituted-4-thiocarbamoyl-5-pyrazolone derivatives (HL1-HL4) is presented as chelating agents for complexation with Fe(III), Ni(II) and Cu(II) metal ions. The synthesized pyrazolone ligands and their newly metal complexes are characterized by different spectral and analytical methods such as UV–Vis, IR, 1H NMR, 13C NMR, ESR, MS, magnetic measurement, and TGA. The spectral data reveal that ligands coordinated to metal ions in a bidentate pattern via O & N atoms of the OH group at C(5) and thiocarbamoyl (–CSNHR) at C(4) of the pyrazolone ring. Also, the analytical data suggest the stoichiometries 2:3 (M:L) for both Cu(II) & Ni(II) complexes and 1:3 for Fe(III) complexes. Besides, the normal magnetic moments values for Fe(III) complexes confirm high spin octahedral structure while the diamagnetic nature of all Ni(II) complexes is consistent with square planar geometry. However, the subnormal magnetic values for Cu(II) complexes suggest the proposal of their binuclear structures. The ESR spectra of the Cu(II) complexes support the distorted square planar geometry with a considerably strong intradimeric spin-exchange interaction. Moreover, the anticancer, antibacterial and antifungal activities are screened. Among the synthesized compounds, HL4 ligand exhibits a significant broad spectrum of action against Gram-positive (S. aureus), Gram-negative bacteria (P. vulgaris), and antifungal potency against A. fumigatus & C. albicans in comparison with gentamicin and ketoconazole drug. Such potency of HL4 could be related to the insertion of the p-chloro in the phenyl group attached to the pharmacophoric thiocarbamoyl group at C(4). Furthermore, IC50 values of two Cu(II) complexes derived from HL2 and HL3 display nearly twofold or threefold more cytotoxicity impact against three cell lines (MCF-7, HCT116 and HepG-2) compared with cis-platin as positive control.

    更新日期:2019-12-11
  • Synthesis, anticancer, molecular docking and QSAR studies of benzoylhydrazone
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-08-08
    Muhammad Taha, Sadia Sultan, Muhammad Herizal, M. Qaiser Fatmi, Manikandan Selvaraj, Kalavathy Ramasamy, Sobia Ahsan Halim, Siong Meng Lim, Fazal Rahim, Kamran Ashraf, Adeeb Shehzad

    To find out effective anticancer compounds we synthesized (1–30) derivatives of 4-isopropylbenzoylhydrazone and evaluated for anticancer potential. The compounds 3, 9, 12, 23, 26 and 28 showed better activities ranging (0.39–1.1 µg/ml) than the standard (1.53 ± 0.01 µg/ml). In line with this, compounds 2, 6, 24, 25 and 29 exhibited better activities compared to the second standard (5FU 4.60 ± 0.01 µg/ml). The best molecular docked complex between the BRCA1 structure and the 1–30 derivatives were analyzed based on the Glide docked score and binding orientation for both the SP and XP mode. The 2D-QSAR analysis reflected a significant correlation between the experimental and the predicted biological activities. The above-mentioned compounds were also assessed by various spectroscopic techniques.

    更新日期:2019-12-11
  • Green synthesis of silver nanoparticles by bloom forming marine microalgae Trichodesmium erythraeum and its applications in antioxidant, drug-resistant bacteria, and cytotoxicity activity
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-08-08
    R.S. Sathishkumar, A. Sundaramanickam, R. Srinath, T. Ramesh, K. Saranya, M. Meena, P. Surya

    In the present study, we developed an eco-friendly method of stable silver nanoparticles (AgNPs) production using the aqueous extract of Trichodesmium erythraeum. The biosynthesized AgNPs were characterized using UV–Vis spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), Energy-Dispersive X-ray (EDX), and X-ray diffraction (XRD). The results affirmed that synthesized AgNPs were crystalline in nature, cubical in shape, and the average size of T. erythraeum silver nanoparticles (TENPs) was 26.5 nm. The antioxidant potential of synthesized AgNPs (500 µg/ml) was 77.01 ± 0.17% in DPPH, 67.5 ± 0.22% in Deoxy-ribose, 52.77 ± 0.42% in ABTS and 88.12 ± 0.26% in nitric oxide radical scavenging assays. The antibacterial results showed excellent inhibition against the clinical strains (Staphylococcus aureus and Proteus mirabilis) and drug-resistant bacterial strains such as E. coli (AmikacinR), S. aureus (TetracyclineR) and S. pneumoniae (PenicillinR). The maximum anti-proliferative effect of TENPs was seen using 50 µg concentration against He La and MCF-7 cell lines, and IC50 values were 25.0 ± 0.50 µg/ml and 30.0 ± 0.50 µg/ml, respectively, at 24 h.

    更新日期:2019-12-11
  • Importance of thorough conformational analysis in modelling transition metal-mediated reactions: Case studies on pincer complexes containing phosphine groups
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-08-06
    Kristin Munkerup, Michael Thulin, Davin Tan, Xiaozhi Lim, Richmond Lee, Kuo-Wei Huang
    更新日期:2019-12-11
  • Novel quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety as potential bactericides and fungicides: Design, synthesis, characterization and 3D-QSAR analysis
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-08-05
    Xiaobin Wang, Haoran Hu, Xu Zhao, Min Chen, Tingting Zhang, Chunwen Geng, Yudong Mei, Aimin Lu, Chunlong Yang

    A series of quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety were designed, synthesized and evaluated for their biological activities against phytopathogenic microorganisms. Antimicrobial bioassays in vitro indicated that most of the target compounds exhibited more significant antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) than the agricultural bactericide thiadiazole-copper. A comparative molecular similarity index analysis (CoMSIA) model with cross-validated q2 and non-cross-validated r2 values of 0.561 and 0.882 was generated to investigate the structure-activity relationships of title compounds against Xoo. Title compound 6w, which was rationally designed under the guidance of obtained CoMSIA model, exhibited the excellent anti-Xoo effect in vitro with an EC50 value of 29.10 μg/mL, which is approximately 3-folds more effective than thiadiazole-copper (113.93 μg/mL). In addition, compound 6i demonstrated the impressive antifungal effects against Rhizoctonia solani (Rs) and Fusarium graminearum (Fg) in vitro, with the corresponding EC50 values of 11.01 μg/mL and 36.00 μg/mL, which is obviously better than the agricultural fungicide hymexazol (76.74 μg/mL and 56.19 μg/mL, respectively). The above researches indicate that quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety could be further studied as template molecules of novel agricultural microbicides.

    更新日期:2019-12-11
  • 更新日期:2019-12-11
  • Review on augmentation in photocatalytic activity of CoFe2O4 via heterojunction formation for photocatalysis of organic pollutants in water
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-07-24
    Sonu, Vishal Dutta, Sheetal Sharma, Pankaj Raizada, Ahmad Hosseini-Bandegharaei, Vinod Kumar Gupta, Pardeep Singh

    In previous years, cobalt ferrite has gained huge consideration in the field of semiconductor photocatalysis for waste water treatment. Cobalt ferrite and its derivatives own tunable magnetic properties which results in higher absorption capability in comparison with other photocatalyst semiconductors. In the current review, a brief overview of CoFe2O4 as a semiconductor photocatalyst is presented and ferromagnetic behaviour of CoFe2O4 is also discussed. Few drawbacks such as agglomeration, photocorrosion and recombination rate of electrons-holes are also discussed. For the enhancement of photocatalytic action of cobalt ferrite, the role of cobalt ferrite with type I, type II, direct Z-scheme, solid state Z-scheme heterojunctions, Schottky and p-n heterojunctions based on different heterostructures were also discussed. In conclusive outlook formation of cobalt ferrite based heterojunctions is best approach for the enhancement of photocatalytic performance. This is because heterojunction formation enhanced the rate of charge separation and thus reduced the electron–hole recombination. Herein, this review highlights the CoFe2O4 based heterojunctions for the photodegradation of noxious organic pollutants in water. Furthermore, the future expectations and challenges in exploiting CoFe2O4 nanocomposites for water treatment, also discussed in precise conclusion of this review.

    更新日期:2019-12-11
  • Novel CaCO3/g-C3N4 composites with enhanced charge separation and photocatalytic activity
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-07-19
    Peng Lu, Xueli Hu, Yujie Li, Yazhou Peng, Meng Zhang, Xue Jiang, Youzhou He, Min Fu, Fan Dong, Zhi Zhang

    A novel CaCO3/graphitic carbon nitride (g-C3N4) photocatalyst was synthesized for the first time via a facile calcination method using CaCO3 and melamine as precursors. The as-prepared samples were characterized using various techniques, such as scanning and transmission electron microscopy, X-ray diffraction, Brunauer-Emmett-Teller analysis, as well as Fourier-transform infrared, X-ray photoelectron, photoluminescence, and UV–vis diffuse reflectance spectroscopy. The results of the experiments confirm the successful coupling of CaCO3 to g-C3N4. The photocatalytic activity of the synthesized CaCO3/g-C3N4 composites was evaluated by assessing their performance in the photocatalytic degradation of crystal violet (CV) in water under visible light irradiation. The analysis shows that CaCO3/g-C3N4 exhibits higher photocatalytic activity towards CV degradation (76.0%) than pristine g-C3N4 (21.6%) and CaCO3 (23.2%). Radical trapping and electron spin resonance experiments show that hydroxyl radicals (OH) and holes (h+) are the key reactive species in the photocatalytic process. The enhanced photocatalytic activity of the composite is mainly attributed to the efficient separation rate of electron-hole pairs achieved through the incorporation of CaCO3.

    更新日期:2019-12-11
  • Regioselective hydroamination of diphenylphosphorylallenes to synthesize β-aminophosphine oxides
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-07-17
    Xin-Yu Gong, Yang Chen, Li-Heng Ruan, Yu-Ke Liu, Jing Sun

    The regioselective hydroamination of diphenylphosphorylallenes has been developed using secondary amines as the amination reagents. This reaction protocol could be realized under ligand and transition metal-free conditions at room temperature and is tolerated to a diverse range of diphenylphosphorylallenes and amine substrates, affording a series of β-aminophosphine oxides in good yields after the reduction of the enamine intermediates.

    更新日期:2019-12-11
  • Novel bio compactable silver nanowires and nanocubes: An effective treatment against carbapenem and vancomycin resistant strains isolated from cancer patients
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-07-11
    Jiya Jose, Anju K. Nair, Nandakumar Kalarikkal, Oluwatobi Oluwafemi, Sabu Thomas

    Blood stream infections in the cancer patients are a critical problem which leads to considerable rate of mortality and morbidity. In view of this herein, we account the response of Poly Vinyl Pyrrolidone (PVP) coated silver nanowires (Ag-NWs) and silver nano cubes (Ag-NCs) towards carbapenem (Escherichia coli) and vancomycin (Staphylococcus aureus) resistant strains as well as to human epithelial cells. The prepared PVP capped silver nanomaterials were in the range of 80 nm (Ag-NC) and 25 nm (Ag-NW) as observed from Transmission Electron Microscopy (TEM). Though the selected strains were resistant to carbapenem and vancomycin, PVP capped Ag-NWs and Ag-NCs could inhibit the growth of these strains. These nanomaterials could break the cell wall and damage the genetic material of these strains as observed by death rate assay and alkaline comet assay. Furthermore, we have shown that toxicity of Ag-NWs and Ag-NCs precisely follows the dose retort pattern. Even though the resistant strains were susceptible to a concentration of 10 µg ml−1 of silver nanomaterials the epithelial cells were not affected by the same concentration. It is also confirmed with live dead staining assay and observed that metabolic activities of epithelial cells were not affected by a concentration of 10 µg ml−1. Overall, this work suggests that these nanomaterials can be utilized to treat the multiple drug resistant strains from cancer patients.

    更新日期:2019-12-11
  • Facial synthesis of sulfinic esters via copper-catalyzed reaction of sulfonyl hydrazides with alcohols in air
    J. Saudi Chem. Soc. (IF 2.759) Pub Date : 2019-07-10
    Lingjuan Chen, Jiangxin Pu, Ping Liu, Bin Dai

    The efficient Cu-catalyzed esterification of sulfonyl hydrazides with alcohols in air is described, providing sulfinic esters in good yields and broad scope. Mechanistic studies suggest that the reaction likely proceeds through free-radical formation including arylthio radical and arylsulfonyl radical, while arylsulfuric acid are the major esterification intermediate in this transformation.

    更新日期:2019-12-11
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