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The Importance of Substituent Position for Antibacterial Activity in the Group of Thiosemicarbazide Derivatives Molecules (IF 4.6) Pub Date : 2024-03-17 Sara Janowska, Joanna Stefańska, Dmytro Khylyuk, Monika Wujec
The search for new antibacterial compounds is still a huge challenge for scientists. Each new chemotherapy drug is not 100% effective when introduced into treatment. Bacteria quickly become resistant to known structures. One promising group of new compounds is thiosemicarbazides. In the presented work, we looked for the relationship between structure and antibacterial activity within the group of thiosemicarbazide
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Enhanced Photovoltaic Performance of Asymmetrical Benzo Dithiophene Homopolymer Donor Materials in Nonfullerene Acceptor-Based Organic Photovoltaics Molecules (IF 4.6) Pub Date : 2024-03-17 Wei Xu, Li Du, Zhengkun Du, Wei He, Hongxiang Li, Guojuan Li, Cheng Yang, Pei Cheng, Zhong Cao, Donghong Yu
Although much promising synthetic progress in conjugated polymer-based organic solar cells (OSCs) has resulted in significant improvement in power conversion efficiencies (PCEs) of from over 15 to >19.0% in the last five years, the sophisticated and complex reactions from at least two families’ monomers with remarkably different electron push–pull effects could still pose an unavoidable material burden
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Purification and Biochemical Characterization of Polyphenol Oxidase Extracted from Wheat Bran (Wan grano) Molecules (IF 4.6) Pub Date : 2024-03-17 Kun Yu, Wei He, Xiaoli Ma, Qi Zhang, Chunxu Chen, Peiyan Li, Di Wu
Currently, little is known about the characteristics of polyphenol oxidase from wheat bran, which is closely linked to the browning of wheat product. The wheat PPO was purified by ammonium sulfate precipitation, DEAE-Sepharose ion-exchange column, and Superdex G-75 chromatography column. Purified wheat PPO activity was 11.05-fold higher, its specific activity was 1365.12 U/mg, and its yield was 8.46%
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Multifaceted Characterization for the Hepatic Clearance of Graphene Oxide and Size-Related Hepatic Toxicity Molecules (IF 4.6) Pub Date : 2024-03-17 Zongyi Su, Wei Chen, Shanshan Liang, Hao Fang, Minglu Zhang, Meng Wang, Lingna Zheng, Bing Wang, Yi Bi, Weiyue Feng
Understanding the final fate of nanomaterials (NMs) in the liver is crucial for their safer application. As a representative two-dimensional (2D) soft nanomaterial, graphene oxide (GO) has shown to have high potential for applications in the biomedical field, including in biosensing, drug delivery, tissue engineering, therapeutics, etc. GO has been shown to accumulate in the liver after entering the
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Mass-Spectrometry-Based Research of Cosmetic Ingredients Molecules (IF 4.6) Pub Date : 2024-03-17 Alina Florina Serb, Marius Georgescu, Robert Onulov, Cristina Ramona Novaconi, Eugen Sisu, Alexandru Bolocan, Raluca Elena Sandu
Cosmetic products are chemical substances or mixtures used on the skin, hair, nails, teeth, and the mucous membranes of the oral cavity, whose use is intended to clean, protect, correct body odor, perfume, keep in good condition, or change appearance. The analysis of cosmetic ingredients is often challenging because of their huge complexity and their adulteration. Among various analytical tools, mass
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Novel Meta-Diamide Compounds Containing Sulfide Derivatives Were Designed and Synthesized as Potential Pesticides Molecules (IF 4.6) Pub Date : 2024-03-17 Jingwen Wu, Shuaihui Dang, Yan Zhang, Sha Zhou
The meta-diamide (m-diamide) insecticide, Broflanilide, was characterized by its high efficiency, low toxicity and lack of cross-resistance with traditional GABA receptors. In accordance with the principles of drug molecular design, easily derivable sulfur with diverse bioactivities was introduced while leading with the parent Broflanilide. Twelve novel m-diamide target compounds containing sulfide
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Molecular Insights into the Enhanced Activity and/or Thermostability of PET Hydrolase by D186 Mutations Molecules (IF 4.6) Pub Date : 2024-03-17 Zhi Qu, Lin Zhang, Yan Sun
PETase exhibits a high degradation activity for polyethylene terephthalate (PET) plastic under moderate temperatures. However, the effect of non-active site residues in the second shell of PETase on the catalytic performance remains unclear. Herein, we proposed a crystal structure- and sequence-based strategy to identify the key non-active site residue. D186 in the second shell of PETase was found
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Quantification of Trimethylamine-N-Oxide and Trimethylamine in Fish Oils for Human Consumption Molecules (IF 4.6) Pub Date : 2024-03-17 Dominik Dörfel, Sascha Rohn, Eckard Jantzen
Supplementing fish oil is one of the strategies to reduce the risk of cardiovascular disease, the leading cause of death around the world. Contradictorily, fish oil may also contain trimethylamine-N-oxide, a recently emerged risk factor for cardiovascular disease, as well as one of its precursors, trimethylamine. A method suitable for routine quantification of trimethylamine-N-oxide and trimethylamine
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The Causality between Human Immunoglobulin G (IgG) N-Glycosylation and Aging: A Mendelian Randomization Study Molecules (IF 4.6) Pub Date : 2024-03-14 Wenxin Sun, Xuening Jian, Jie Zhang, Xiaoni Meng, Haotian Wang, Deqiang Zheng, Lijuan Wu, Youxin Wang
Background: Immunoglobulin G (IgG) N-glycosylation is considered a potential biomarker for aging and various pathological conditions. However, whether these changes in IgG N-glycosylation are a consequence or a contributor to the aging process remains unclear. This study aims to investigate the causality between IgG N-glycosylation and aging using Mendelian randomization (MR) analysis. Methods: We
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Selective CO2 Capture from CO2/N2 Gas Mixtures Utilizing Tetrabutylammonium Fluoride Hydrates Molecules (IF 4.6) Pub Date : 2024-03-14 Hyeonjin Kim, Yun-Ho Ahn
Gas hydrates, a type of inclusion compound capable of trapping gas molecules within a lattice structure composed of water molecules, are gaining attention as an environmentally benign gas storage or separation platform. In general, the formation of gas hydrates from water requires high-pressure and low-temperature conditions, resulting in significant energy consumption. In this study, tetrabutylammonium
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Oral Delivery of Astaxanthin via Carboxymethyl Chitosan-Modified Nanoparticles for Ulcerative Colitis Treatment Molecules (IF 4.6) Pub Date : 2024-03-14 Wen Zhang, Xinping Zhang, Xinyi Lv, Ao Qu, Wenjing Liang, Limin Wang, Pei Zhao, Zijian Wu
The oral delivery strategy of natural anti-oxidant and anti-inflammatory agents has attracted great attention to improve the effectiveness of ulcerative colitis (UC) treatment. Herein, we developed a novel orally deliverable nanoparticle, carboxymethyl chitosan (CMC)-modified astaxanthin (AXT)-loaded nanoparticles (CMC-AXT-NPs), for UC treatment. The CMC-AXT-NPs were evaluated by appearance, morphology
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Investigation of the Performance of Hastelloy X as Potential Bipolar Plate Materials in Proton Exchange Membrane Fuel Cells Molecules (IF 4.6) Pub Date : 2024-03-14 Jiacheng Zhong, Zimeng Liu, Meng Zhang, Feng Liu, Wenjin Li, Beirui Hou, Wenmin Zhang, Chunwang Zhao, Mingxing Gong
The phase, mechanical properties, corrosion resistance, hydrophobicity, and interfacial contact resistance of Hastelloy X were investigated to evaluate its performance in proton exchange membrane fuel cells (PEMFCs). For comparison, the corresponding performance of 304 stainless steel (304SS) was also tested. Hastelloy X exhibited a single-phase face-centered cubic structure with a yield strength of
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Valorization of Coffee Silverskin Using Extraction Cycles and Water as a Solvent: Design of Process Molecules (IF 4.6) Pub Date : 2024-03-15 Aziadé Chemat, Didier Touraud, Rainer Müller, Werner Kunz, Anne-Sylvie Fabiano-Tixier
Coffee silverskin is a byproduct of the coffee industry, appearing in large quantities during the roasting step. In this work, a sober and simple water process is proposed, using extractions cycles, to produce valuable products including (a) an extract rich in caffeine, (b) possibly pure caffeine, and (c) insoluble fibers. The hypothetical number of necessary cycles was calculated and compared to the
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Biocatalytic Synthesis of Coumarin S-Glycosides: Towards Non-Cytotoxic Probes for Biomedical Imaging and Sensing Molecules (IF 4.6) Pub Date : 2024-03-16 Nastassja Burrini, Arnaud Pâris, Guillaume Collet, Pierre Lafite, Richard Daniellou
This study unveils an innovative method for synthesizing coumarin S-glycosides, employing original biocatalysts able to graft diverse carbohydrate structures onto 7-mercapto-4-methyl-coumarin in one-pot reactions. The fluorescence properties of the generated thio-derivatives were assessed, providing valuable insights into their potential applications in biological imaging or sensing. In addition, the
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Tangeretin Mitigates Trimethylamine Oxide Induced Arterial Inflammation by Disrupting Choline–Trimethylamine Conversion through Specific Manipulation of Intestinal Microflora Molecules (IF 4.6) Pub Date : 2024-03-16 Yu Cao, Changlong Leng, Kuan Lin, Youwei Li, Meiling Zhou, Mei Zhou, Xiji Shu, Wei Liu
Previous studies have revealed the microbial metabolism of dietary choline in the gut, leading to its conversion into trimethylamine (TMA). Polymethoxyflavones (PMFs), exemplified by tangeretin, have shown efficacy in mitigating choline-induced cardiovascular inflammation. However, the specific mechanism by which these compounds exert their effects, particularly in modulating the gut microbiota, remains
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Selective Generation of Aldimine and Ketimine Tautomers of the Schiff Base Condensates of Amino Acids with Imidazole Aldehydes or of Imidazole Methanamines with Pyruvates—Isomeric Control with 2- vs. 4-Substituted Imidazoles Molecules (IF 4.6) Pub Date : 2024-03-16 Greg Brewer, Cynthia Brewer, Raymond J. Butcher, Peter Zavalij
The Schiff base condensation of 5-methyl-4-imidazole carboxaldehyde, 5Me4ImCHO, and the anion of an amino acid, H2N-CH(R)CO2− (R = -CH3, -CH(CH3)2 and -CH2CH(CH3)2), gives the aldimine tautomer, Im-CH=N-CH(R)CO2−, while that of 5-methylimidazole-4-methanamine, 5MeIm-4-CH2NH2, with a 2-oxocarboxylate anion, R-C(O)-CO2−, gives the isomeric ketimine tautomer, Im-CH2-N=C(R)CO2−. All are isolated as the
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Recent Advances in Preparing Transparent Phosphor Ceramics for High-Index Color Rendering and High-Power Lighting Molecules (IF 4.6) Pub Date : 2024-03-16 Boshen Du, Wanyuan Li, Lin Zhang, Pei Chen, Fengniu Lu
In recent years, high-power white light-emitting diode (wLED)/laser diode (wLD) lighting sources based on transparent phosphor ceramic (TPC) materials have attracted increasing application interest in automotive headlights, projection displays, and space navigation lighting due to their superior brightness, lighting distance, compactness, lifespan, and environmental resistance compared with the widely
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Synthetic Methods and Pharmacological Potentials of Triazolothiadiazines: A Review Molecules (IF 4.6) Pub Date : 2024-03-16 Mohamed S. Mostafa, Ibrahim Ali M. Radini, Naglaa M. Abd El-Rahman, Rizk E. Khidre
This review article examines the synthetic pathways for triazolothiadiazine derivatives, such as triazolo[3,4-b]thiadiazines, triazolo[5,1-b]thiadiazines, and triazolo[4,3-c]thiadiazines, originating from triazole derivatives, thiadiazine derivatives, or thiocarbohydrazide. The triazolothiadiazine derivatives exhibit several biological actions, including antibacterial, anticancer, antiviral, antiproliferative
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Advances in Understanding the Antioxidant and Antigenic Properties of Egg-Derived Peptides Molecules (IF 4.6) Pub Date : 2024-03-16 Mihaela Brumă (Călin), Ina Vasilean, Leontina Grigore-Gurgu, Iuliana Banu, Iuliana Aprodu
Pepsin, trypsin and proteinase K were used in the present study to hydrolyse the proteins from whole eggs, yolks or whites, and the resulting hydrolysates were characterised in terms of antioxidant and IgE-binding properties, using a combination of in vitro and in silico methods. Based on the degree of hydrolysis (DH) results, the egg yolk proteins are better substrates for all the tested enzymes (DH
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Chemoenzymatic Synthesis of Selegiline: An Imine Reductase-Catalyzed Approach Molecules (IF 4.6) Pub Date : 2024-03-16 Yuliang Hu, Jinping Bao, Dongyu Tang, Shushan Gao, Fei Wang, Zhongtao Ding, Chengsen Cui
(R)-Homobenzylic amines are key structural motifs present in (R)-selegiline, a drug indicated for the treatment of early-stage Parkinson’s disease. Herein, we report a new short chemoenzymatic approach (in 2 steps) towards the synthesis of (R)-selegiline via stereoselective biocatalytic reductive amination as the key step. The imine reductase IR36-M5 mutant showed high conversion (97%) and stereoselectivity
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Ameliorative Effect of Areca Nut Polyphenols on Adverse Effects Induced by Lipopolysaccharides in RAW264.7 Cells Molecules (IF 4.6) Pub Date : 2024-03-16 Luyan Zou, Shuhan Yi, Yuanliang Wang
In Asian regions, areca nuts are tropical fruits that are extensively consumed. The areca nut contains a lot of polyphenols and its safety is unknown. In this research, we investigated the effects of lipopolysaccharides (LPS) and areca nut polyphenols (ANP) on normal RAW264.7 cells. The results showed that LPS stimulated adverse effects in normal cells by affecting cytokine production. The GO analysis
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Mechanistic Insights into the Inhibition of a Common CTLA-4 Gene Mutation in the Cytoplasmic Domain Molecules (IF 4.6) Pub Date : 2024-03-16 Jikang Xu, Yu Zhang, Lijuan Shen, Lingyu Du, Hongjuan Xue, Bin Wu, Bo OuYang
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a pivotal immune checkpoint receptor, playing a crucial role in modulating T-cell activation. In this study, we delved into the underlying mechanism by which a common mutation, G199R, in the cytoplasmic domain of CTLA-4 impacts its inhibitory function. Utilizing nuclear magnetic resonance (NMR) spectroscopy and biochemical techniques, we mapped the conformational
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Synthesis of Alkenylgold(I) Complexes Relevant to Catalytic Carboxylative Cyclization of Unsaturated Amines and Alcohols Molecules (IF 4.6) Pub Date : 2024-03-16 Shun Hase, Kyohei Yamashita, Yoshihito Kayaki
The carboxylation of unsaturated amine and alcohol compounds, including 4-benzylamino-1-phenyl-1-butyne (homopropargylamine), 2-butyne-1-ol (propargylic alcohol), and 2,3-butadiene-1-ol (allenylmethyl alcohol), using the hydroxidogold(I) complex, AuOH(IPr) [IPr = 1,3-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene], produces corresponding alkenylgold(I) complexes with a cyclic urethane or carbonate framework
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Lewis-Acid-Catalyzed (3+2) Annulation of 2-Indolylmethanols with Propargylic Alcohols to Access Cyclopenta[b]indoles Molecules (IF 4.6) Pub Date : 2024-03-12 Teng-Fei Wu, Zhao-Jie Fu, Yi-Rui Zhang, Zong-Wang Qiu, Bao Qiong Li, Shao-Shuai Chen, Han-Peng Pan, Ai-Jun Ma, Xiang-Zhi Zhang
Herein, a Sc(OTf)3-catalyzed (3+2) annulation of 2-indolylmethanols with propargylic alcohols is reported. The reaction proceeds via a Friedel–Crafts-type allenylation/5-exo-annulation cascade. In the reaction, 2-indolylmethanol is used as a three-carbon synthon, and propargyl alcohol is used as a two-carbon synthon. This method provides a direct and high-yield pathway for synthetically useful cyclopenta[b]indoles
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Preparation and Properties of Reversible Emulsion Drilling Fluid Stabilized by Modified Nanocrystalline Cellulose Molecules (IF 4.6) Pub Date : 2024-03-13 Fei Liu, Yongfei Li, Xuewu Wang, Zhizeng Xia
Reversible emulsion drilling fluids can concentrate the advantages of water-based drilling fluids and oil-based drilling fluids. Most of the existing reversible emulsion drilling fluid systems are surfactant-based emulsifier systems, which have the disadvantage of poor stability. However, the use of modified nanoparticles as emulsifiers can significantly enhance the stability of reversible emulsion
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Mass Spectrometry for Biomedical and Food Analysis Molecules (IF 4.6) Pub Date : 2024-03-14 Xianjiang Li, Wen Ma
Biomedical and food analysis has always been an important topic that closely relates to health [...]
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Liquid Chromatography with Tandem Mass Spectrometry Analysis of Carboxymethyl Lysine in Indonesian Foods Molecules (IF 4.6) Pub Date : 2024-03-15 Patricia Budihartanti Liman, Mulyana, Yenny, Ratna Djuwita
There is little data on directly measured carboxymethyl lysine (CML) content in Indonesian foods. This study aimed to generate a database of CML values in foods commonly consumed in West Java and West Sumatra. The results were to be used to update our previous estimated CML values. CML values in food samples were measured using high-pressure liquid chromatography with tandem mass spectrometry (HPLC-MS/MS)
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Enzymatic Synthesis of New Acetoacetate–Ursodeoxycholic Acid Hybrids as Potential Therapeutic Agents and Useful Synthetic Scaffolds as Well Molecules (IF 4.6) Pub Date : 2024-03-15 Valentina Venturi, Elena Marchesi, Daniela Perrone, Valentina Costa, Martina Catani, Simona Aprile, Lindomar Alberto Lerin, Federico Zappaterra, Pier Paolo Giovannini, Lorenzo Preti
Ursodeoxycholic acid (UDCA) and acetoacetate are natural compounds present in the human intestine and blood, respectively. A number of studies highlighted that besides their well-known primary biological roles, both compounds possess the ability to influence a variety of cellular processes involved in the etiology of various diseases. These reasons suggested the potential of acetoacetate–UDCA hybrids
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The New Elastomeric Compounds Made of Butyl Rubber Filled with Phyllosilicates, Characterized by Increased Barrier Properties and Hydrophobicity and Reduced Chemical Degradation Molecules (IF 4.6) Pub Date : 2024-03-15 Aleksandra Smejda-Krzewicka, Emilia Irzmańska, Konrad Mrozowski, Agnieszka Adamus-Włodarczyk, Natalia Litwicka, Krzysztof Strzelec, Małgorzata I. Szynkowska-Jóźwik
The aim of the study was to produce new elastomeric materials containing butyl rubber (IIR) filled with silica and phyllosilicates (vermiculite, montmorillonite, perlite or halloysite tubes) with enhanced hydrophobicity and barrier properties and reduced chemical degradation. It was found that the filler type had a significant impact on the degree of cross-linking of butyl rubber and the properties
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Isohexide-Based Tunable Chiral Platforms as Amide- and Thiourea-Chiral Solvating Agents for the NMR Enantiodiscrimination of Derivatized Amino Acids Molecules (IF 4.6) Pub Date : 2024-03-15 Federica Cefalì, Anna Iuliano, Federica Balzano, Gloria Uccello Barretta, Valerio Zullo, Carlo Baldassari
New arylamide- and arylthiourea-based chiral solvating agents (CSAs) were synthesized starting from commercially available isomannide and isosorbide. The two natural isohexides were transformed into the three amino derivatives, having isomannide, isosorbide, and isoidide stereochemistry, then the amino groups were derivatized with 3,5-dimethoxybenzoyl chloride or 3,5-bis(trifluoromethyl)phenyl isothiocyanate
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Traceability of Microplastic Fragments from Waste Plastic Express Packages Using Near-Infrared Spectroscopy Combined with Chemometrics Molecules (IF 4.6) Pub Date : 2024-03-15 Xianshu Fu, Xiangliang Pan, Jun Chen, Mingzhou Zhang, Zihong Ye, Xiaoping Yu
The pollution from waste plastic express packages (WPEPs), especially microplastic (MP) fragments, caused by the blowout development of the express delivery industry has attracted widespread attention. On account of the variety of additives, strong complexity, and high diversity of plastic express packages (PEPs), the multi-class classification of WPEPs is a typical large-class-number classification
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Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny Molecules (IF 4.6) Pub Date : 2024-03-15 Najla A. Alshaye, Mohamed K. Elgohary, Mahmoud S. Elkotamy, Hatem A. Abdel-Aziz
COX-2 plays a key role in converting arachidonic acid into prostaglandins. This makes it a significant target for treating inflammation. Selective COX-2 inhibitors have marked a new phase in inflammatory treatment, providing significant effectiveness while reducing negative side effects. Herein, we aimed at the design and synthesis of new anti-inflammatory agents 5a–f, 7a–b, 10a–f, and 13a–b with expected
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Synthesis and Bioactive Properties of the Novel Coloured Compound Obtained via the Laccase-Mediated Transformation of 5-Aminosalicylic Acid Molecules (IF 4.6) Pub Date : 2024-03-15 Jolanta Polak, Marcin Grąz, Katarzyna Szałapata, Justyna Kapral-Piotrowska, Kamila Wlizło, Marcin Polak, Anna Jarosz-Wilkołazka
Biocatalysis processes based on oxidoreductases, such as fungal laccase, are important for discovering new organic compounds with broad structures and potential applications. They include bioactive compounds, which can be obtained through laccase-mediated oxidation of organic substrates having hydroxyl and/or amino groups especially, e.g., 5-aminosalicylic acid (5-ASA) is characterised for its potential
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Optimization of Bear Oil Extraction Process and Hair Growth Activity Molecules (IF 4.6) Pub Date : 2024-03-15 Ziming Wang, Qiu Wang, Yingrui Jin, Kun Guo, Xiaoling Wang, Xueting Feng
According to ancient Chinese books, bear grease has the effects of strengthening muscles and bones, which is beneficial for weakness, but there is relatively little research on it. Thus, the extraction of it is beneficial for compensating for research in this area. In this study, a uniform experimental design method was used to optimize the extraction process of bear grease by enzymatic hydrolysis
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The Stability Prediction and Epitaxial Growth of Boron Nitride Nanodots on Different Substrates Molecules (IF 4.6) Pub Date : 2024-03-15 Muhamad Jalu Purnomo, Yosi Febrita, Okto Dinaryanto, Wojciech Gierlotka, Ing-Song Yu
Boron nitride (BN) is a wide-bandgap material for various applications in modern nanotechnologies. In the technology of material science, computational calculations are prerequisites for experimental works, enabling precise property prediction and guidance. First-principles methods such as density functional theory (DFT) are capable of capturing the accurate physical properties of materials. However
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Recent Advances in the Nutritional Value, Chemical Compositions, Pharmacological Activity, and Application Value of Orychophragmus violaceus: A Comprehensive Review Molecules (IF 4.6) Pub Date : 2024-03-15 Xiaolan Chen, Guangjie Zhang, Wenjin Cui, Chunbo Ge, Bin Li, Min Li, Shuchen Liu, Lin Wang
Orychophragmus violaceus (L.) O. E. Schulz (Brassicaceae) is widely distributed and plentiful in China and has been widely used for its application in ornamental, oil, ecology, foraging, and food. Recent studies have revealed that the main components of Orychophragmus violaceus include flavonoids, alkaloids, phenylpropanoids, phenolic acids, terpenoids, etc., which have pharmacological activities such
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Advances and Prospects in the Study of Spherical Polyelectrolyte Brushes as a Dopant for Conducting Polymers Molecules (IF 4.6) Pub Date : 2024-03-15 Na Su
Owing to their special structure and excellent physical and chemical properties, conducting polymers have attracted increasing attention in materials science. In recent years, tremendous efforts have been devoted to improving the comprehensive performance of conducting polymers by using the technique of “doping.” Spherical polyelectrolyte brushes (SPBs) bearing polyelectrolyte chains grafted densely
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Steroidal Saponins from Water Eggplant (Fruits of Solanum torvum) Exhibit Anti-Epileptic Activity against Pentylenetetrazole-Induced Seizure Model in Zebrafish Molecules (IF 4.6) Pub Date : 2024-03-15 Rui Ren, Ming-yan Zhang, Tengyun Shu, Ya-ting Kong, Li-hua Su, Hai-zhou Li
The fruits of Solanum torvum Swartz, a wild relative of eggplant, are consumed as a wild vegetable in tropical regions of Africa, Asia, and South America. In traditional Chinese medicine, it is believed to have anti-inflammatory and sedative effects. In the Philippines, water decoction is used to treat hyperactivity disorder. Twenty-two steroidal saponins were isolated and purified from the fruits
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Synthesis of α,ω-bis-Mercaptoacyl Poly(alkyl oxide)s and Development of Thioether Cross-Linked Liposome Scaffolds for Sustained Release of Drugs Molecules (IF 4.6) Pub Date : 2024-03-15 Spyridon Mourtas, Georgios Kourmoulakis, Stavros Kremezis, Pavlos Klepetsanis, Sophia G. Antimisiaris
With the aim to develop novel scaffolds for the sustained release of drugs, we initially developed an easy approach for the synthesis of α,ω-homobifunctional mercaptoacyl poly(alkyl oxide)s. This was based on the esterification of the terminal hydroxyl groups of poly(alkyl oxide)s with suitably S-4-methoxytrityl (Mmt)-protected mercapto acids, followed by the removal of the acid labile S-Mmt group
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Reflections on a Copenhagen–Minneapolis Axis in Bioorganic Chemistry Molecules (IF 4.6) Pub Date : 2024-03-15 George Barany, Paul R. Hansen
The international peptide community rejoiced when one of its most distinguished members, Morten Meldal of Denmark, shared the 2022 Nobel Prize in Chemistry. In fact, the regiospecific solid-phase “copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes to azides” (CuACC) reaction—that formed the specific basis for Meldal’s recognition—was reported first at the 17th American Peptide Symposium
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A Thiourea Derivative of 2-[(1R)-1-Aminoethyl]phenol as a Chiral Sensor for the Determination of the Absolute Configuration of N-3,5-Dinitrobenzoyl Derivatives of Amino Acids Molecules (IF 4.6) Pub Date : 2024-03-15 Federica Aiello, Alessandra Recchimurzo, Federica Balzano, Gloria Uccello Barretta, Federica Cefalì
In the exploration of chiral solvating agents (CSAs) for nuclear magnetic resonance (NMR) spectroscopy designed for the chiral analysis of amino acid derivatives, notable advancements have been made with thiourea–CSAs. 1-TU, derived from 2-[(1R)-1-aminoethyl]phenol and benzoyl isothiocyanate, is effective in the enantiodifferentiation of N-3,5-dinitrobenzoyl (N-DNB) amino acids. In order to broaden
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Allicin and Cancer Hallmarks Molecules (IF 4.6) Pub Date : 2024-03-15 Wamidh H. Talib, Media Mohammed Baban, Aya O. Azzam, Jenan J. Issa, Alaa Y. Ali, Alia Kh. AlSuwais, Sana Allala, Lina T. AL Kury
Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in the discovery and development of new therapeutic agents owing to their biologically active compounds. They offer a promising avenue for developing effective anticancer medications because of their low toxicity, diverse chemical structures, and ability to target various cancers. Allicin is one of the main
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A Laboratory Experimental Study on Enhancing the Oil Recovery Mechanisms of Polymeric Surfactants Molecules (IF 4.6) Pub Date : 2024-03-15 Junhui Guo, Fulin Wang, Yunfei Zhao, Peng Wang, Tianzhi Wang, Jixiang Yang, Bo Yang, Liangliang Ma
In order to evaluate the physical and chemical properties of polymer surfactants and analyze their oil displacement mechanisms, three types of poly-surfactant used in the Daqing oil field were chosen to be researched, and the oil displacement effects were studied using poly-surfactants of different viscosity, dehydrating rate, and core permeability. The main purpose is to determine the reasonable range
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Deep Eutectic Solvents as Agents for Improving the Solubility of Edaravone: Experimental and Theoretical Considerations Molecules (IF 4.6) Pub Date : 2024-03-12 Tomasz Jeliński, Maciej Przybyłek, Magdalena Mianowana, Kinga Misiak, Piotr Cysewski
In this study, both practical and theoretical aspects of the solubility of edaravone (EDA) in Deep Eutectic Solvents (DESs) were considered. The solubility of edaravone in some media, including water, can be limited, which creates the need for new efficient and environmentally safe solvents. The solubility of EDA was measured spectrophotometrically and the complex intermolecular interactions within
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Recent Advances in Polymer Nanocomposites: Unveiling the Frontier of Shape Memory and Self-Healing Properties—A Comprehensive Review Molecules (IF 4.6) Pub Date : 2024-03-13 Huma Jamil, Muhammad Faizan, Muhammad Adeel, Teofil Jesionowski, Grzegorz Boczkaj, Aldona Balčiūnaitė
Shape memory and self-healing polymer nanocomposites have attracted considerable attention due to their modifiable properties and promising applications. The incorporation of nanomaterials (polypyrrole, carboxyl methyl cellulose, carbon nanotubes, titania nanotubes, graphene, graphene oxide, mesoporous silica) into these polymers has significantly enhanced their performance, opening up new avenues
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Optimization of Antioxidant Activity of Compounds Generated during Ginseng Extract Fermentation Supplemented with Lactobacillus Molecules (IF 4.6) Pub Date : 2024-03-13 Shuiqing Lin, Yuxiao Wu, Qian Huang, Zhiting Liu, Juan Xu, Ruifeng Ji, Natalia V. Slovesnova, Xin He, Lin Zhou
Ginseng holds high medicinal and cosmetic value, with stem and leaf extracts garnering attention for their abundant bioactive ingredients. Meanwhile, fermentation can enhance the effectiveness of cosmetics. The aim of this study was to optimize ginseng fermentation to produce functional cosmetics. Ginseng stem and leaf extracts were fermented with five different strains of lactic acid bacteria. Using
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Enhancement of Broadband Reverse Saturable Absorption of Red/Black Phosphorus Heterojunction Molecules (IF 4.6) Pub Date : 2024-03-13 Jingjing Wang, Fulai Liu, Yunfei Li, Long Chen, Yong Chen, Hailong Zhang, Zheng Xie
Although laser technology brings convenience to production and daily life, it also causes high-energy damage. Therefore, there is an urgent need to develop optical limiting materials for laser protection. In this study, a novel nonlinear optical material, red/black phosphorus lateral heterojunction, is successfully prepared through solvothermal and ultrasonic treatment. Using the Z−scan method, the
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Oxyresveratrol Improves Cognitive Impairments and Episodic-like Memory through Modulating Neuroinflammation and PI3K-Akt Signaling Pathway in LPS-Induced Mice Molecules (IF 4.6) Pub Date : 2024-03-13 Guangling Yin, Chunxing Pan, Hong Liu, Changzhi Dong, Xia Chang, Wei Zhou, Shanshan Wang, Zhiyun Du
Oxyresveratrol is one of the active ingredients derived from mulberry branch with strong anti-inflammatory bioactivity. In this research, we want to explore if oxyresveratrol can improve cognitive impairments and episodic-like memory and its mechanism. In LPS-induced BV-2 cells, 25 μM OXY can significantly inhibit the expression of NO and alter the M1/M2 polarization by regulating M1/M2 phenotype makers
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Design and Synthesis of Novel Squaraine-Based Fluorescent Probe for Far-Red Detection of Chymotrypsin Enzyme Molecules (IF 4.6) Pub Date : 2024-03-14 Shekhar Gupta, Priyanka, Sai Kiran Mavileti, Shyam S. Pandey, Tamaki Kato
Chymotrypsin, a crucial enzyme in human digestion, catalyzes the breakdown of milk proteins, underscoring its significance in both health diagnostics and dairy quality assurance. Addressing the critical need for rapid, cost-effective detection methods, we introduce a groundbreaking approach utilizing far-red technology and HOMO-Förster resonance energy transfer (FRET). Our novel probe, SQ-122 PC, features
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Physical Grinding of Prefabricated Co3O4 and MCM-22 Zeolite for Fischer–Tropsch Synthesis: Impact of Pretreatment Procedure on the Dispersion and Catalytic Performance Molecules (IF 4.6) Pub Date : 2024-03-14 Hua-Ping Ren, Zhi-Xia Xie, Shao-Peng Tian, Si-Yi Ding, Qiang Ma, Yu-Zhen Zhao, Zhe Zhang, Jiao-Jiao Fu, Qing-Qing Hao
To improve the mess-specific activity of Co supported on zeolite catalysts in Fischer–Tropsch (FT) synthesis, the Co-MCM-22 catalyst was prepared by simply grinding the MCM-22 with nanosized Co3O4 prefabricated by the thermal decomposition of the Co(II)-glycine complex. It is found that this novel strategy is effective for improving the mess-specific activity of Co catalysts in FT synthesis compared
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Could the Length of the Alkyl Chain Affect the Photodynamic Activity of 5,10,15,20-Tetrakis(1-alkylpyridinium-4-yl)porphyrins? Molecules (IF 4.6) Pub Date : 2024-03-14 Miryam Chiara Malacarne, Marzia Bruna Gariboldi, Emanuela Marras, Enrico Caruso
Photodynamic therapy (PDT) is a minimally invasive treatment that uses the combination of a photosensitizing agent (PS) and light to selectively target solid tumors, as well as several non-neoplastic proliferating cell diseases. After systemic administration, PSs are activated by localized irradiation with visible light; in the presence of adequate concentrations of molecular oxygen, this causes the
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Structure, Synthesis, and Catalytic Performance of Emerging MXene-Based Catalysts Molecules (IF 4.6) Pub Date : 2024-03-14 Zhengxiang Sun, Rui Wang, Vitaly Edwardovich Matulis, Korchak Vladimir
As traditional fossil fuel energy development faces significant challenges, two-dimensional layered materials have become increasingly popular in various fields and have generated widespread research interest. MXene is an exceptional catalytic material that is typically integrated into functional composite materials with other substances to enhance its catalytic-reaction performance. Improving the
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Myricetin Amorphous Solid Dispersions—Antineurodegenerative Potential Molecules (IF 4.6) Pub Date : 2024-03-14 Natalia Rosiak, Ewa Tykarska, Judyta Cielecka-Piontek
Our research aimed to develop an amorphous solid dispersion (ASD) of myricetin (MYR) with Polyvinylpyrrolidone K30 (PVP30) to enhance its solubility, dissolution rate, antioxidant, and neuroprotective properties. Employing a combination of solvent evaporation and freeze drying, we successfully formed MYR ASDs. XRPD analysis confirmed complete amorphization in 1:8 and 1:9 MYR-PVP weight ratios. DSC
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Exploring Deactivation Reasons of Biomass-Based Phosphorus-Doped Carbon as a Metal-Free Catalyst in the Catalytic Dehydroaromatization of n-Heptane Molecules (IF 4.6) Pub Date : 2024-03-14 Fei Yu, Siyuan Liu, Bo Liu
Catalytic dehydroaromatization of n-alkanes into high-value aromatics has garnered extensive interest from both academia and industry. Our group has previously reported that phosphorus-doped carbon materials exhibit high selectivity for C-H bond activation in the dehydroaromatization of n-hexane. In this study, using n-heptane as a probe, we synthesized biomass-based phosphorus-doped carbon catalysts
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The Use of Chitin for the Removal of Nitrates and Orthophosphates from Greenhouse Wastewater Molecules (IF 4.6) Pub Date : 2024-03-14 Tomasz Jóźwiak, Artur Mielcarek, Urszula Filipkowska
The study investigated the possibility of using chitin flakes as an unconventional sorbent for the removal of orthophosphates and nitrates from greenhouse wastewater (GW). The effluent parameters were as follows: 66.2 mg P-PO4/L, 566.0 mg N-NO3/L, 456.0 mg S-SO4/L, 13.7 mg Cl−/L, 721 mg Ca2+/L, 230 mg Mg2+/L, hardness 11.3 °dH, and pH 5.4. The scope of the research included determinations of the influence
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Study on the Selectivity of Molecular Imprinting Materials Determined through Hydrogen Bonding on Template Molecular Structures of Flavonoids Molecules (IF 4.6) Pub Date : 2024-03-14 Siyue Guan, Yue Wang, Ting Hu, Lingling Che, Xiaoqiao Wang, Yike Huang, Zhining Xia
Molecular imprinting technology is widely used for the specific identification of compounds, but the selective recognition mechanisms of the same compounds still need to be further studied. Based on differences in hydrogen bond size and orientation, molecularly imprinted polymers (MIPs) were designed to adsorb flavonols with the same parent core and different hydroxyl groups. A surface-imprinted material
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Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management Molecules (IF 4.6) Pub Date : 2024-03-14 Fahrul Nurkolis, Rudy Kurniawan, Elvan Wiyarta, Rony Abdi Syahputra, Reggie Surya, Nurpudji Astuti Taslim, Trina Ekawati Tallei, Raymond Rubianto Tjandrawinata, Eli Y. Adashi, Bonglee Kim
Diabetes, particularly type 2 diabetes (T2D), is the main component of metabolic syndrome. It is highly prevalent and has drastically increased with sedentary lifestyles, notably behaviors linked to ease of access and minimal physical activity. Central to this condition is insulin, which plays a pivotal role in regulating glucose levels in the body by aiding glucose uptake and storage in cells, and
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Comprehensive Characterization of Triterpene Saponins in Rhizoma Panacis Japonici by Offline Two-Dimensional Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry Molecules (IF 4.6) Pub Date : 2024-03-14 Subinuer Yasen, Chengrui Li, Siyuan Wang, Yixin Dong, Hang Li, Jie Chen, Yifan Meng, Ping Yu, Haiyan Zou
Rhizoma Panacis Japonici (RPJ) is an ancient herbal medicine from China that has long been employed for its medicinal benefits in relieving arthritis physical debility and diverse afflictions. The primary bioactive constituents found in RPJ are triterpene saponins, which exhibit numerous pharmacological actions, including anti-inflammatory, antioxidant, and immunomodulating effects. The present study
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Viscosity Flow Curves of Agar and the Bounded Ripening Growth Model of the Gelation Onset Molecules (IF 4.6) Pub Date : 2024-03-14 Vincenzo Villani
The gelation kinetics of agar aqueous solutions were studied by means of the viscosity flow curves using a coaxial Couette cylinder viscometer. The viscosity curves show an unusual sigmoidal trend or an exponential decay to a viscous steady state. An original theory of gelation kinetics was developed considering the coarsening of increasingly larger and more stable clusters due to Ostwald ripening
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Recent Advances in the Chromatographic Analysis of Emerging Pollutants in Dairy Milk: A Review (2018–2023) Molecules (IF 4.6) Pub Date : 2024-03-14 Dina Ashraf, Rana Morsi, Muhammad Usman, Mohammed A. Meetani
Emerging pollutants (EPs) encompass natural or synthetic substances found in the environment that pose potential risks, but which have only recently been recognized or monitored. EPs consist of various categories, including pesticides, pharmaceuticals, hormones, mycotoxins, and endocrine-disrupting chemicals (EDCs). Through several pathways, EPs can access food, potentially leading to health impacts