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Antibacterial Mechanisms of Constituents from Galla chinensis Revealed by Experimental and Virtual Screening-Based Studies J. Chem. (IF 3.0) Pub Date : 2024-3-18 Meilan Liu, Tingting Lin, Liyuan Yao, Hongfeng Chen, Yu Lu, Zhengguo Tao, Haiquan Zhao, Sheng-Xiang Qiu, Liyun Zhao
Many traditional Chinese medicines (TCMs) have been confirmed to have antibacterial activities. However, very few substances have been found to be active against Gram-negative bacteria. This study aimed to identify antimicrobial activity substances against Gram-negative bacteria from fourteen TCMs. Fourteen TCMs with antibacterial potential were chosen for quantitative extraction and antibacterial
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Effect of Ripening and Extraction Method on the Physicochemical Properties of Pectin Extracted from Peels of Apem and Apantu Plantain Cultivars in Ghana J. Chem. (IF 3.0) Pub Date : 2024-3-14 Desmond Asamoah Bruce Otu, Frederick William Akuffo Owusu, Prince George Jnr Acquah, Mariam El Boakye-Gyasi, Yayra Edzor-Agbo, Raphael Johnson, Marcel Tunkumgnen Bayor, Mary-Ann Archer
Fruit waste has emerged as a significant environmental issue in recent years, adding to the global burden. In Ghana, the extensive use of plantains at various stages of ripeness results in substantial waste during each processing stage, leading to disposal challenges. Interestingly, these wastes often hold considerable economic value and can be repurposed as a source of valuable raw materials or products
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Multistaged In Silico Discovery of the Best SARS-CoV-2 Main Protease Inhibitors amongst 3009 Clinical and FDA-Approved Compounds J. Chem. (IF 3.0) Pub Date : 2024-3-6 Ibrahim H. Eissa, Abdulrahman M. Saleh, Sara T. Al-Rashood, Abdul-Aziz M. M. El-Attar, Ahmed M. Metwaly
As a follow-up to our teamwork’s former work against SARS-CoV-2, eight compounds (ramelteon (68), prilocaine (224), nefiracetam (339), cyclandelate (911), mepivacaine (2325), ropivacaine (2351), tasimelteon (2384), and levobupivacaine (2840)) were revealed as the best potentially active SARS-CoV-2 inhibitors targeting the main protease (PDB ID: 5R84), Mpro. The compounds were named in the midst of
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Design and In Silico and In Vitro Evaluations of a Novel Nicotinamide Derivative as a VEGFR-2 Inhibitor J. Chem. (IF 3.0) Pub Date : 2024-3-1 Ibrahim H. Eissa, Muhammad Abd ElGayed Bkrah, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Dalal Z. Husein
A new nicotinamide derivative, (E)-N-(4-(1-(2-(4-benzamidobenzoyl)hydrazone)ethyl)phenyl)nicotinamide, was designed as a VEGFR-2 inhibitor. Utilizing the density functional theory (DFT) calculations, the three-dimensional structure of the designed compound was determined, shedding light on its stability and reactivity. Molecular docking revealed its capability to inhibit VEGFR-2, which was further
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Sea Urchin-Like MnO2/Biomass Carbon Composite Electrode Material for High-Performance Supercapacitors J. Chem. (IF 3.0) Pub Date : 2024-2-27 Xiaoyu Zhao, Ning Wang, Lei Li, Zixun Fang, Shoufeng Tang, Jianmin Gu
Manganese oxide materials for high-performance supercapacitors are as popular electrode materials of energy storage devices based on their high theoretical capacitance. However, its development is limited by its poor electrical conductivity and insufficient contact surface area, which causes the supercapacitor to fail to achieve its theoretical specific capacitance. In this paper, unique sea urchin-like
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Antioxidant and Neuroproliferative Effects of THL-3-PTD5 Peptide Derived from Hydramacin-1 Antimicrobial Peptide J. Chem. (IF 3.0) Pub Date : 2024-2-24 Ping-Chien Lee, Ching-Chun Lin, Hui-Hsuan Hsu, Feng-Di T. Lung
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by reduced dopamine levels in the brain, affecting over 6 million people worldwide. While current treatments for patients primarily focus on symptom relief, there is a necessity for the development of novel therapeutic agents due to the presence of side effects and declining effectiveness. Functional peptides, known for their high
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Mechanistics of pH-Dependent Sulfmyoglobin Formation: Spin Control and His64 Proton Relay J. Chem. (IF 3.0) Pub Date : 2024-2-21 Angel D. Rodriguez-Mackenzie, Lysmarie Santos-Velazquez, Héctor D. Arbelo-Lopez, Troy Wymore, Juan Lopez-Garriga
The chemistry of hydrogen sulfide (H2S) has been directed towards physiologically relevant hemeproteins, including myoglobin, hemoglobin, and other similar proteins. Despite substantial efforts, there remains a need to elucidate the mechanism and identify the species involved in the reaction between oxy-hemeproteins and H2S. Here, we summarize both our experimental data and computational modeling results
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Selective mPGES-1 Inhibitor Ameliorated Adjuvant-Induced Arthritis in the Rat Model J. Chem. (IF 3.0) Pub Date : 2024-2-13 Min Ji Kim, Hwi-Ho Lee, Choi Kim, Ja Yeon Lee, Kyung-Sook Chung, Kyung-Tae Lee, Jae Yeol Lee
Endogenous prostaglandin E2 (PGE2) plays an important role in maintaining the homeostasis conditions. However, the overexpression of PGE2 in response to various inflammatory stimulations is an important target of anti-inflammatory drugs. Both inducible COX-2 (cyclooxygenase-2) and mPGES-1 (microsomal prostaglandin E2 synthase-1) enzymes are responsible for the inflammatory overexpressed PGE2 production
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Antibacterial and Antioxidant Activities of Triterpenoids and Cyclic 1,7-Diarylheptanoids from the Stem Bark of Myrica salicifolia: A Combined Experimental and Computational Study J. Chem. (IF 3.0) Pub Date : 2024-2-12 Abraham Dilnesa Gashaw, Kibrom Gebreheiwot Bedane, Taye B. Demissie, Japheth O. Ombito, Estifanos Ele Yaya, Mekonnen Abebayehu Desta
Myricasalicifolia A Rich (Myricaceae) is a tree growing in Central and East Africa. Traditionally, the plant is used to treat malaria, respiratory disorders, inflammations, and infections. A new compound, 3β-O-trans-caffeoylisomyricadiol (7), was isolated from MeOH : CHCl3 (2 : 1) extract of the stem bark of Myrica salicifolia along with seven known compounds, namely, myricanone (1), myricanol (2)
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Characterization of Gold Nanoparticles Synthesized with Zingiber zerumbet Extracts J. Chem. (IF 3.0) Pub Date : 2024-2-7 Wayne C. Liao, Collin S. Liao, Yu-Chen Lin, Ching-Yi Lien
Gold nanoparticles have been used as drug carriers and imaging reagents. The plant extract-capped gold nanoparticles provide better properties than chemically synthesized gold nanoparticles. In this study, Zingiber zerumbet extract-mediated green production of gold nanoparticles (Z. zerumbet@Au NPs) was established. Based on the UV-visible spectroscopy and transmission electron microscope (TEM) results
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Oil Palm Biomass Sap-Rotten Rice as a Source to Remove Metal Ions and Generate Electricity as By-Products through Microbial Fuel Cell Technology J. Chem. (IF 3.0) Pub Date : 2024-2-6 Anoud Saud Alshammari, Ghada Mohamed Aleid, Alamri Rahmah Dhahawi Ahmad, Asma D. Alomari, Shehu Sa’ad Abdullahi, Rania Edrees Adam Mohammad
Microbial fuel cell (MFC) is a new and interesting technology that can be used to treat wastewater without using electricity. The current research focuses on electron generation, which is one of the technique’s major challenges. According to the latest literature, the study was planned to successfully remove the metals from artificial wastewater at high concentrations and generate electricity. On average
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Synthesis and Antitubercular Evaluation of Diverse Glycosylated Ureas from D-Glucose J. Chem. (IF 3.0) Pub Date : 2024-2-2 Neetu Tripathi, Vinod K. Tiwari
N, N-disubstituted glycosylated ureas have been synthesized in good-to-excellent yields by 1,4-conjugate addition of amines to glycosylated olefinic esters followed by reaction of resulting glycosyl β-amino esters with diisocyanates. The developed sugar-based molecules were well characterized by extensive standard spectroscopic analysis including NMR (1H, 13C, and DEPT), IR, MS, and elemental analysis
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HPLC Method Development and Validation for the Determination of Apixaban and Clopidogrel in Novel Fixed-Dose Combination Tablets J. Chem. (IF 3.0) Pub Date : 2024-1-25 Ni’meh Al-Shami, Hani Naseef, Ramzi Moqadi, Feras Kanaze
A simple, fast, and accurate high-performance liquid chromatographic (HPLC) method is developed, optimized, and validated for a fixed-dose combination of apixaban (APX) and clopidogrel (CLOP) tablets according to ICH guidelines. Chromatographic separation of the drugs was performed on a BDS Hypersil C18 (4.6 150 mm, 5 μm), with acetonitrile (ACN) and trifluoroacetic acid (TFA) in the ratio 48 : 52
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Analysis of the Influence of Different Processing Methods on the Main Effective Components in Oviductus Ranae by High-Performance Liquid Chromatography with Diode Array Detector J. Chem. (IF 3.0) Pub Date : 2024-1-23 Yang Xu, Xianwen Yue, Jihong Chi, Huailei Yang, Ying Wang, Yongsheng Wang, Peng Yu, Huiwei Bao
Oviductus Ranae (OR) is one of the “treasures of Changbai Mountain” in China. It is used clinically for the treatment of infirmity after illness, fatigued spirit, cough, hemoptysis, and so forth. In this study, a simple and sensitive high-performance liquid chromatography-diode array detector (HPLC-DAD) method was developed for the simultaneous determination of five main effective components (1-methyl
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Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration J. Chem. (IF 3.0) Pub Date : 2024-1-22 Mihaela Maria Budiul, Gabriela Vlase, Daniel Negru, Dorinel Okolišan, Ionela-Amalia Bradu, Alexandra Tăşală, Alexandru Pahomi, Titus Vlase, Daniela Jumanca, Atena Galuscan, Paula Sfirloaga, Nicoleta Carabă, Roxana Popescu, Anamaria Matichescu
The aim of the present study was to formulate new variants of synthetic and animal-source bone materials coated with different biopolymers, containing antibiotics (ampicillin and oxacillin) and alendronate drugs. Validation consists in establishing mixtures that do not present interactions between components. These materials should act as a drug delivery system alongside the bone base. Natural polymers
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Fabrication of Silk Fibroin Film with Strong Anticoagulant Property from the Synergy of Deep Eutectic Solvents and UV-Light Irradiation J. Chem. (IF 3.0) Pub Date : 2024-1-22 Chunyan Yu, Meiling Pu, Qiuyang Chen, Shitao Yu, Lu Li
As a biological macromolecule, silk fibroin (SF) has great application potential in anticoagulant. However, its complex molecular structure leads to its poor solubility, which limits the application of SF. In this study, a novel SF film with strong anticoagulant properties was fabricated through the synergistic effect of LiBr deep eutectic solvents (DESs) and UV-light irradiation. Under the optimum
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Development of Thiazolidinone-Based Pyrazine Derivatives: Synthesis, Molecular Docking Simulation, and Bioevaluation for Anti-Alzheimer and Antibacterial Activities J. Chem. (IF 3.0) Pub Date : 2024-1-22 Uzma Jehangir, Shoaib Khan, Rafaqat Hussain, Yousaf Khan, Farhan Ali, Asma Sardar, Samina Aslam, Mozhgan Afshari
It is well recognized that heterocyclic compounds have exceptional biomedical applications, which has led scientists to become increasingly interested in their use in this field in the recent past. It is the aim of this study, using a multistep method based on thiazolidinone derivative synthesis, to synthesize thiazolidinone derivatives derived from pyrazine molecules (1–12). As a result of analyzing
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Identification of the Mechanism of Action of the Index Components of Banxia Xiexin Decoction for Gastric Cancer through Network Pharmacology, Bioinformatics, and Molecular Docking Analysis J. Chem. (IF 3.0) Pub Date : 2024-1-13 Xiaoji Niu, Mingyue Ma, Shoumei Wang, Aiyan Hu, Yi Xu, Liang Zhu, Shuhui Zhang
Banxia Xiexin decoction (BXD) is a traditional prescription widely used to treat gastrointestinal conditions, including gastric cancer. Through network pharmacology, bioinformatics, and molecular docking analysis, this study aimed to investigate the potential mechanism of the antigastric cancer effect of BXD and pave the way for future research. The network pharmacology analysis used BXD index components
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Thermodynamic Behavior of Pyrite and Arsenopyrite in Preoxidation for Chlorination Leaching of Refractory Gold Concentrate J. Chem. (IF 3.0) Pub Date : 2024-1-10 Chang Sok Kim, Un Chol Han, Hyok Sin, Su Rim Hwang, Jong Min Wang
Recently, preoxidation is an effective pretreatment method of refractory gold ore, which has been widely used due to the high desulfurization, arsenic removal, low environmental pollution, and rapid reaction rate. In this paper, we describe the thermodynamic considerations of preoxidation of pyrite and arsenopyrite, the main minerals of the refractory gold ore, and the effect of the pressure oxidation
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Antimicrobial Evaluation of Anthraquinones and Preanthraquinone from the Root Extract of Aloe kefaensis J. Chem. (IF 3.0) Pub Date : 2024-1-8 Tamiru Fayisa Diriba, Negera Abdissa, Melaku Meshesha, Soressa Gershe Ayana
The aim of this study was to isolate antimicrobial compounds from the roots of Aloe kefaensis, a plant endemic to Ethiopia and used to treat various microbial infections by traditional healers. The air-dried and powdered plant material was sequentially extracted with petroleum ether, dichloromethane, acetone, and methanol. Then, each solvent extract was evaluated for its in vitro antimicrobial activity
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Sorption Mechanisms and Enhancement of Selected Organochlorine Pollutants in Water on Zeolites J. Chem. (IF 3.0) Pub Date : 2024-1-8 Timothy Manda, Solomon Omwoma, Godfrey Okumu Barasa, Anthony M. Pembere, Douglas Sifuna, Livingstone Ochilo, Silas Lagat, Emily Ngeno, Patrick Ssebugere, Christine Betty Nagawa, Christine Kyarimpa
This study investigates the adsorption capacities of selected organochlorines on zeolites, focusing on hexachlorobenzene (HCB), hexachlorotetradecane (HCTD), hexachlorodecane (HCD), hexachlorocyclohexane (HCH), heptachlorodecane (HPCD), octachlorodecane (OCD), dichlorodiphenyltrichloroethane (DDT), and octachlorotetradecane (OCTD). The structures of the organochlorines were optimized and their Frontier
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Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies J. Chem. (IF 3.0) Pub Date : 2024-1-5 Ahmad Ebadi, Aref Karimi, Asrin Bahmani, Zahra Najafi, Gholamabbas Chehardoli
Seventeen new xanthene-1,8-dione derivatives were synthesized and evaluated as cytotoxic agents against the lung carcinoma cell line (A549). Compound 9-(4-(benzyloxy)phenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (4a) showed good cytotoxic effects (34.59 μM) in comparison to cis-platin. Docking results showed 4a could interact with DNA as intercalation. Calculated ligand efficiency of compound
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A Review on Bioactive Phytochemical Constituents and Pharmacological Activities of Aegiceras corniculatum: A Pharmaceutically Important Mangrove Plant J. Chem. (IF 3.0) Pub Date : 2024-1-4 Pritam Sarkar, Tasfiya Rufaidah Ahnaf, Razina Rouf, Jamil Ahmad Shilpi, Shaikh Jamal Uddin
Aegiceras corniculatum, commonly referred to as Khalsi, is a member of the mangrove Myrsinaceae family. The various parts of this plant have been used in traditional medicinal systems for their potential therapeutic effects in conditions such as asthma, microbial infections, diabetes, pain relief, inflammation, cancer, and arthritis. A diverse array of bioactive phytochemicals such as flavonoids, benzoquinones
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Synthesis and Characterization of Parthenium hysterophorus-Mediated ZnO Nanoparticles for Methylene Blue Dye Degradation J. Chem. (IF 3.0) Pub Date : 2024-1-3 Dennis Nzilu, Edwin Madivoli, David Makhanu, Sammy Wanakai, Gideon Kirui, Vincent Mwangi, Patrick Kareru
Herein, zinc oxide nanoparticles (ZnO NPs) were synthesized using Parthenium hysterophorus whole plant aqueous extract as reducing and capping agents. The synthesized ZnO NPs were characterized via UV-Vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS)
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Residue of Pesticides in Fruits, Vegetables, and Their Management in Ethiopia J. Chem. (IF 3.0) Pub Date : 2024-1-3 Yohannes Gelaye, Belete Negash
In Ethiopia, using pesticides to manage pests in the growing of fruits and vegetables is a standard practice. Various classes of pesticides have been approved to combat pests, but the majority of those in use now are outdated broad-spectrum insecticides with significant residual effects on crops of freshly eaten fruits and vegetables. This review reveals that Ethiopia’s assessment of the residual pesticide
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Response Surface Methodology Process Optimization of Biodiesel Production from Castor Seed Oil J. Chem. (IF 3.0) Pub Date : 2023-12-26 Kenatu Angassa, Embaye Tesfay, Tsedekech Gebremeskel Weldmichael, Seble Kebede
The increasing demand for energy and the depletion of fossil fuel resources has led to the search for an alternative energy source. The search for such alternative fuel sources has oriented biodiesel synthesis as the ultimate alternative energy resource of the future. The purpose of this study was to produce castor oil and optimize biodiesel production using full factorial central composite design
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Recent Advances in Efficient Photocatalytic Degradation Approaches for Azo Dyes J. Chem. (IF 3.0) Pub Date : 2023-12-26 Arpita Paul Chowdhury, K. S. Anantharaju, K. Keshavamurthy, Samuel Lalthazuala Rokhum
In recent decades, the textile industry has contributed to continuous pollution in the environment. Synthetic dyes which are commonly found in waste water are azo, sulfur, anthraquinone, triphenylmethyl, indigoid, and phthalocyanine derivatives. These pollutants block the light penetration in water bodies and prevent photosynthesis activity, thereby affecting aquatic life. As an environmental crisis
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Insights into Sulfhemoglobin Detection: UV-Vis and Fluorescence Spectroscopy Correlations J. Chem. (IF 3.0) Pub Date : 2023-12-20 Lysmarie Santos-Velázquez, Juan López-Garriga
The mechanisms by which drugs and several sulfur chemicals induce sulfhemoglobin formation have not yet been elucidated. However, enzymes producing hydrogen sulfide in mammalian tissues and organs suggest sulfhemoglobin and sulfmyoglobin formation mechanisms are more complex than previously hypothesized. The process involves the interaction of H2S with hemoglobin or myoglobin in the presence of O2
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Hypolipidemic Effect of Chloroform Extract of Lagenaria siceraria: Potential Inhibitory Activity of Phytochemicals Targeting the HMG-CoA Reductase Revealed by Molecular Docking and Simulation Studies J. Chem. (IF 3.0) Pub Date : 2023-12-18 Qudsia Kanwal, Mahmood Ahmed, Atiq Ur-Rehman, Aneela Anwar, Samiah Shahid, Atif Shahzad, Attaullah Shah Bukhari, Muhammad Ahmad, Numan Yousaf, Muhammad Muddassar
Conventional systems of medicine play a crucial role in maintaining healthcare. Herbal medicines are intact and less harmful to human beings than synthetic medicines. This study aimed to investigate the phytochemicals and in vivo hypolipidemic effect of chloroform extract of Lagenaria siceraria in Triton X-100 (100 mg/kg body weight) induced hyperlipidemic Wistar rats. The phytochemical characterization
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Fixed-Bed Adsorption of an Azo Dye (Methyl Orange) onto Chemically and Thermally Regenerated Activated Carbons J. Chem. (IF 3.0) Pub Date : 2023-12-15 Idriss Kamdem Taquieteu, Hermann Tamaguelon Dzoujo, Victor Odhiambo Shikuku, Charles Banenzoué, Daniel David Joh Dina
In this study, the effectiveness of the recovery method for spent granular activated carbon (SGAC) for application in dye removal was evaluated. A comparative study of the textural (porosity), compositional, surface functionality, and adsorption performance of chemically (CAR400) and thermally regenerated activated carbons (CAR700 and CAR900) was conducted for the elimination of methyl orange (MO)
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In Silico, SwissADME, and DFT Studies of Newly Synthesized Oxindole Derivatives Followed by Antioxidant Studies J. Chem. (IF 3.0) Pub Date : 2023-12-12 Abdur Rauf, Haroon Khan, Momin Khan, Ali Abusharha, Goncagül Serdaroğlu, Maria Daglia
The compounds were synthesized by refluxing 6-chlorooxindole with 2,3-dichlorobenzaldehyde and 2,6-dichlorobenzaldehyde in the presence of piperidine as a catalyst and characterized by spectroscopic analysis using 1H NMR, 13C NMR, and mass spectrometry as (E)-3-(2,3-dichlorobenzylidene)-6-chloroindolin-2-one (C-1) and (E)-3-(2,6-dichlorobenzylidene)-6-chloroindolin-2-one (C-2). Additionally, in silico
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A DFT and TD-DFT Study of Two Hydralazine Derivatives for Organic Solar Cells and Nonlinear Optical Applications J. Chem. (IF 3.0) Pub Date : 2023-12-8 Remi Nkeih Tamighang, Dodo Lydie Ajifack, Stanley Numbonui Tasheh, Nyiang Kennet Nkungli, Charly Tedjeuguim Tsapi, Julius Numbonui Ghogomu
In recent years, organic molecules have been the subject of in-depth research studies using in silico methods for their applications in solar cells and photonic devices. This study reports a theoretical investigation of the organic solar cell (OSC) and nonlinear optical (NLO) properties of (E)-1-(phthalazin-1-yl)-1-[(pyridin-2-yl)ethylidene]hydralazine (PPEH) and 1-[2-(1-(pyridine-3- yl)ethylidene
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Synthesis, Antimicrobial Studies, and Molecular Docking Simulation of Novel Pyran, Pyrazole, and Pyranopyrazole Derivatives J. Chem. (IF 3.0) Pub Date : 2023-12-7 Mahmoud M. Abdelattey, Zeinab R. Farag, Anouar El Hassane, Moustapha E. Moustapha, Abdelmoneim A. Makhlouf, Ayman M. Yossef
A group of compounds containing pyran, pyrazole, and pyranopyrazole were synthesized (2–4) using a facile and convenient protocol. The structure of the synthesized compounds was elucidated by spectroscopic and elemental analysis. In vitro antimicrobial evaluation was also performed for all synthesized derivatives against human pathogenic bacterial strains such as Escherichia coli, Staphylococcus aureus
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Research Progress in HIV and Mycobacterium tuberculosis Inhibitors Containing Sulfonamide Moiety J. Chem. (IF 3.0) Pub Date : 2023-12-7 Christiana Abimbola Salubi
Numerous studies have reported significant results regarding the efficacy of sulfonamides against Mycobacterium tuberculosis and various HIV strains. This scientific paper provides an overview of the progress made over a decade of sulfonamides against HIV-1 and mycobacteria and its development against extremely drug-resistant (XDR) and multidrug-resistant strains. The reviewed study offers novel insights
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Facile Synthesis of Ethyl Acetate over ZrO2.TiO2 Mixed Oxide Supported Vanadium Boasted Phosphomolybdic Acid Catalyst at Room Temperature J. Chem. (IF 3.0) Pub Date : 2023-12-6 Balaga Viswanadham
Initially, mixed oxide of ZrO2.TiO2 support was synthesized by the sol-gel method, and then after vanadium was incorporated, phosphomolybdic acid (VPMA) was synthesized by the hydrothermal method. VPMA supported on ZrO2.TiO2 support of various VPMA loadings that were synthesized by the impregnation method. The structure, surface area, acidity, and morphology of the materials were analysed by X-ray
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Development of Modified-Release Diclofenac Sodium Capsules Using Blends of Pectin-Clay Multiparticulate Hybrid Systems as Release Retardants J. Chem. (IF 3.0) Pub Date : 2023-12-5 Ofosua Adi-Dako, Frederick William Akuffo Owusu, Isaac Yaw Attah, Doris Kumadoh, Prince George Acquah Jnr, Issaka Nelson, Nii Odartey Hutton-Mills, Karen Yaa Yeboaa Obese, Joseph Adusei Sarkodie, Benoit Banga N’guessan, Awo Afi Kwapong, Christina Osei-Asare, Emmanuel Adase, Mary-Ann Archer
A combination of inorganic and organic hybrid systems is of high research interest as they provide novel hybrid systems for the improvement of existing properties, overcoming limitations of the parent materials, and for the optimization of their controlled release potential. This study sorted to develop and pharmaceutically assess the release profile of diclofenac sodium using cocoa pod husk (CPH)
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Evaluation of Silver Nanoparticles Based on Fresh Cocoa Pods (Theobroma Cacao) Extracts as New Potential Electrode Material J. Chem. (IF 3.0) Pub Date : 2023-11-21 Alex Vincent Somba, Evangéline Njanja, Gullit Deffo, Cyrille Ghislain Fotsop, Kevin Yemele Tajeu, Armel Florian Tchangou Njiemou, François Eya’ane Meva, Theophile Kamgaing
This work focuses on the synthesis of silver nanoparticles using fresh cocoa pods from the “Theobroma cacao” extract plant through the reduction of silver ions (Ag+) into Ag (0) by a green chemistry process, subsequently used as an electrode material. Reaction factors such as pH, incubation time, and silver ion concentration were optimized during the formation of nanoparticles. The synthesized nanoparticles
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Anthropogenic Sources and Risk Assessment of Heavy Metals in Mine Soils: A Case Study of Bontesso in Amansie West District of Ghana J. Chem. (IF 3.0) Pub Date : 2023-11-16 Douglas Siaw Baah, Emmanuel Gikunoo, Emmanuel Kwesi Arthur, Frank Ofori Agyemang, Gordon Foli, Bennetta Koomson, Philipa Opoku
Contamination of the environmental receptors with heavy metals due to mining is a major topical environmental issue in Ghana. This research investigates the possible ecological and human health risks of heavy metal impacts due to mining in the Amansie West District in Ghana. A total of 18 soil samples were taken from the Bontesso illegal mining site in the district and analyzed for the levels of arsenic
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Extraction and Optimization of Tanning Material from Osyris lanceolata Barks: Cleaner Leather Tanning Processing J. Chem. (IF 3.0) Pub Date : 2023-11-14 Zerihun Teshome, Tesfaye Agazhi, Tale Gashew, Biniyam Solomon, Tsion Belay, Belete Baye, Efrem Temach
Tanning is a processing mechanism that prevents the collagen fibers from putrefaction to maximize the hydrothermal stability of leather. Tannin agents extracted from plants were used in leather production in a process called vegetable tanning. Vegetable tanning is an eco-friendly tanning method when compared to chrome tanning. Chrome tanning is the most common method of tanning hides. Currently, chrome
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Development and Validation of an RP-HPLC Method for the Quantitative Analysis of Triclosan in Human Urine J. Chem. (IF 3.0) Pub Date : 2023-11-13 Prince Karikari, James Oppong-Kyekyeku, Edmund Ekuadzi, Samuel Oppong Bekoe, Rita Opoku, Daniel Nimako Amprako, Emmanuel Addo-Yobo, Sandra Kwarteng Owusu, Bernard Arhin, Adegoke G. Falade, Ganiyu Arinola, Adeleye S. Bakarey, John I. Anetor, Kevin J. Mortimer
Triclosan (TCS), a synthesized chlorinated phenolic compound, is commonly utilized in consumable products as an antimicrobial agent. TCS has sparked widespread awareness because of its toxicity and possible negative effect on public health in recent years. In this study, a highly sensitive, fast, and cost-effective isocratic reversed-phase high-performance liquid chromatography (RP-HPLC) method coupled
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Prediction of Refractive Indices of Binary Mixtures of Ionic Liquids and Water J. Chem. (IF 3.0) Pub Date : 2023-11-7 Mohd Sajid Ali, Mohammad Tariq
In the present work, we have successfully predicted the refractive indices of binary mixtures containing ionic liquids (ILs) and water as a component following the approach of Gladstone–Dale and Newton. These approaches were proposed as adequate to predict the refractive indices of mixtures containing imidazolium-based ILs with water or ethanol. It requires just the knowledge of the density and refractive
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Efficient Electro-Oxidation of 2-Propanol at Platinum- and Gold-Modified Palladium Nanocatalysts J. Chem. (IF 3.0) Pub Date : 2023-11-3 Kareem Ayman, Yaser M. Asal, Ahmad M. Mohammad, Islam M. Al-Akraa
This study aims at investigating the catalytic performance of Pd, Pd/Pt, and Pd/Au nanocatalysts toward the 2-propanol electro-oxidation reaction (2POR) in an alkaline medium. The catalyst components (Pd, Pt, and Au) were sequentially electrodeposited onto the glassy carbon (GC) electrode surface and further characterized using electrochemical (cyclic voltammetry (CV)) and materials (field-emission
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Copper- and Ligand-Free Sonogashira Cross-Coupling: Access to Novel 3-Aminoindole Derivatives and Their Biological Evaluations J. Chem. (IF 3.0) Pub Date : 2023-11-3 Tshikani D. Rikhotso, Kgomotso W. Poopedi, Winston Nxumalo, Tlabo C. Leboho
Indole-containing compounds are widely distributed in the plant and animal kingdom, and their biological activity and pharmacological properties have prompted research into their chemical properties. This study developed a one-pot methodology for the synthesis of 3-aminoindole derivatives using copper- and ligand-free Sonogashira cross-coupling reaction conditions. The synthesised 3-aminoindole derivatives
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Antimicrobial Activities of Some Constituents Isolated from a Kenyan Medicinal Plant, Capparis fascicularis DC J. Chem. (IF 3.0) Pub Date : 2023-10-31 Mary W. Kagika, Sumesh C. Chhabra, James O. M. Nonoh, Ahmed Hassanali
Background of the Study. Capparis fascicularis DC. is an indigenous medicinal plant belonging to the family Capparaceae found in Nyandarua County, Nairobi, Kenya, and many parts of Africa. It is a shrub whose roots are used traditionally to treat colds. Aim. The aim of the present study is to carry out antimicrobial activities of solvent extracts of different parts of Capparis fascicularis, characterize
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Salting-Out Assisted Liquid-Liquid Extraction of Cr (VI) from Water Samples before Its Determination by UV-Vis Spectrophotometry J. Chem. (IF 3.0) Pub Date : 2023-10-30 Jote Dame, Feyisa Wedajo, Guyo Jilo Molole, Abera Gure
This paper proposes salting-out assisted liquid-liquid extraction for selective extraction of a Cr (VI)-1,5-diphenylcarbazide complex before its determination by UV-Vis spectrophotometry. Parameters affecting the complexation process and the extraction efficiency of the method were studied. The highest extraction efficiency was obtained when acetonitrile was used as an extraction solvent and (NH4)2SO4
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Bioconvection Flow in the Presence of Casson Nanoparticles on a Stretching/Shrinking Vertical Sheet with Chemical Reaction J. Chem. (IF 3.0) Pub Date : 2023-10-26 B. Arun, M. Deivanayaki, Selvakumar Kuppusamy Vaithilingam
A Casson nanoparticle is used in this study to investigate the effects of toxic reactions, temperatures, and concentrations on convective heat transfer flow across a stretching/shrinking vertical sheet. The goal is to convert the control linear partial differential equations (PDEs) into an ordinary differential equations (ODEs) set and analyses them statistically using the Bvp4c technique in MATLAB
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Nanomaterials for Targeted Drug Delivery through Skin to Treat Various Diseases: Recent Trends and Future Perspective J. Chem. (IF 3.0) Pub Date : 2023-10-17 Nazish Mumtaz, Muhammad Imran, Ayesha Javaid, Shoomaila Latif, Nazim Hussain, Liviu Mitu
There is an increased trend of drug delivery via skin due to its convenience and affordability. To accomplish this task in a better way and more successfully, nanotechnology has opened the door to transport drugs for the treatment of acute diseases in unique ways. For partially solvable drugs especially, designing new drug transportation systems is always challenging. However, it has been fixed by
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Extracellular Synthesis of Iron Oxide Nanoparticles Using an Extract of Bacillus circulans: Characterization and In Vitro Antioxidant Activity J. Chem. (IF 3.0) Pub Date : 2023-10-16 Ghulam Rabani, Muhammad Dilshad, Aamir Sohail, Aqsa Salman, Saba Ibrahim, Iqra Zafar, Hafiz Muhammad Arshad
This study explores the biosynthesis of iron oxide nanoparticles (IONPs) using Bacillus circulans bacterial supernatant as an inexpensive and sustainable alternative to traditional synthesis approaches. The resulting nanoparticles were found to have a uniform size distribution and a spherical shape and agglomerated to form clusters as observed through scanning electron microscopy (SEM). The average
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Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents J. Chem. (IF 3.0) Pub Date : 2023-10-10 Mirna Jabbour, Mohammad Ammar Al-Khayat, Mahmoud Al-Ktaifani
Purpose. To synthesize new isoindole-1,3(2H)-dione derivatives by molecular hybridization of gabapentin and pregabalin with phthalic anhydride derivatives and to evaluate their biological activity as promising antioxidant, antimicrobial, and anticancer agents. Method. Molecular hybridization was successfully achieved by two procedures; synthesized compounds were characterized using analytical and spectral
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Simulation Study of the Air Separation Performance of Cr-MIL-101 in High-Altitude Environments J. Chem. (IF 3.0) Pub Date : 2023-10-9 Ying-Chao Wang, Yuan-Zhe Li, Ming-Ming Zhai, Cheng-Cheng Zhao, Kang-Ning Xie, Er-Ping Luo, Chi Tang, Chen-Xu Zhang
The most severe challenge for troops in a high-altitude environment is hypoxia. Pressure swing adsorption coupled with membrane separation is an ideal solution for oxygen production in high-altitude areas, but the molecular sieve membranes and organic membranes used in this technique are greatly affected by the ambient temperature, humidity, and pressure. Compared with traditional porous materials
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Antibiofilm and Anti-Quorum Sensing Potential of Safely-Synthesized Hydrated Zirconium Oxide-Coated Alginate Beads against Some Pathogenic Bacteria J. Chem. (IF 3.0) Pub Date : 2023-10-6 Alfred Ngenge Tamfu, Yasemin Ispirli Dogaç, Ozgur Ceylan, Andreea Botezatu Dediu, Selahattin Bozkurt, Rodica Mihaela Dinica
Water is essential to life, but access to uncontaminated water remains a global challenge. Metal oxides possess particular characteristics required for removing heavy metals, inorganic and organic pollutants from wastewater as well as inhibiting microorganisms. Zirconium oxide and alginate which are nontoxic materials were used to synthesize hydrated zirconium oxide-alginate coated materials, ZAB-1
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Design, Synthesis, and Biological Activity Evaluation of Novel AZT and Adenosine-Derived 1,2,3-Triazoles J. Chem. (IF 3.0) Pub Date : 2023-9-28 Duc Anh Le, Ngoc Hung Truong, Van Dung Vu, Thanh Huyen Doan, Minh Tri Le, Thi Huong Nguyen, Manh Cuong Nguyen, Huu Nghi Do, Duc Bao Ninh, Phong Le, Thi Phuong Thao Nguyen, Khac Vu Tran, Van Chinh Luu
CuSO4/hydrazine hydrate was used as a catalyst system for copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) of AZT and 5′-azido adenosine with terminal alkynes to give 30 novel 1,2,3-triazole derivatives. Screening for their anticancer, anti-inflammatory, angiotensin-converting enzyme 2 (ACE2), and 3C-like protease (3CLpro) inhibitory activities showed that several triazoles of AZT containing
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Careyarboside A: A New Flavan-3-ol Glycoside from the Stems of Careya arborea (Lecythidaceae) J. Chem. (IF 3.0) Pub Date : 2023-9-25 Yeon Woo Jeong, Jung A. Lee, Eun-Kyung Ahn, Jae-Shin Kang, Hye Woo Byun, H. E. Keo Omaliss, Chun Whan Choi, Seong Su Hong
A new flavan-3-ol glycoside, compound 1 (careyarboside A), was isolated from the ethanol extract of the stems of Careya arborea, together with six known compounds. Of these, three phenolic glycosides (leonuriside A, picraquassioside D, and careyarboside B) have never been previously isolated from genus Careya and family Lecythidaceae. Their chemical structures were identified using spectroscopic data
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Synthesis of Nanoporous Biochar from Rice Husk for Adsorption of Methylene Blue J. Chem. (IF 3.0) Pub Date : 2023-9-22 Dan Dang, Lei Mei, Gaimeng Yan, Wenju Liu
In this study, rice husk charcoal prepared with KOH and KOH-NaOH as activators were investigated as adsorbents for the removal of methylene blue from aqueous solutions in order to improve the utilisation of rice husk. Firstly, the rice husk carbon was morphologically and chemically characterised using scanning electron microscopy, specific surface area analyser, and infrared spectroscopy. Secondly
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Novel Thiosemicarbazone Derivatives from Furan-2-Carbaldehyde: Synthesis, Characterization, Crystal Structures, and Antibacterial, Antifungal, Antioxidant, and Antitumor Activities J. Chem. (IF 3.0) Pub Date : 2023-9-14 Wilfredo Hernández, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Maik Icker, Harald Krautscheid, Lothar Beyer, Carmen Tamariz-Angeles, Percy Olivera-Gonzales
Ten new thiosemicarbazone derivatives, furan-2-carbaldehyde thiosemicarbazone (1), 3-methyl-furan-2-carbaldehyde thiosemicarbazone (2), 5-hydroxymethyl-furan-2-carbaldehyde thiosemicarbazone (3), 5-trifluoromethyl-furan-2-carbaldehyde thiosemicarbazone (4), 5-nitro-furan-2-carbaldehyde thiosemicarbazone (5), 5-phenyl-furan-2-carbaldehyde thiosemicarbazone (6), 5-(2-fluorophenyl)-furan-2-carbaldehyde
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Effects of Solid-State Fermentation with the Ganoderma spp. and Coriolus versicolor on the Total Phenol Contents and Antioxidant Properties on Black Soybean J. Chem. (IF 3.0) Pub Date : 2023-9-14 Yanting Li, Lina Xu, Shang Guo
Aim of this study was to evaluate the influence of solid-state fermentation of 4 strains ((Ganoderma oregonense (GO), Ganoderma lucidum (GL), Ganoderma sinensis (GS), and Coriolus versicolor (CV))) on the nutrients, functional ingredients, and antioxidant activity in black soybean. As a result, after fermentation by 3 strains of Ganoderma spp. and CV, the contents of crude protein, crude fat, reducing
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The Effect of Pomegranate-Black Carrot Juice on Serum and Erythrocytes of Sedentary Subjects Exposed to Exhausting Exercise J. Chem. (IF 3.0) Pub Date : 2023-9-13 Kursat Yusuf Aytac, Ahmet Ozkaya, Aykut Oztekin, Vedat Cinar, Taner Akbulut, Ramazan Demirdag, Veysel Comaklı, Kenan Bozbay
Background. In this study, the effects of pomegranate-black carrot juice mixture on serum and erythrocytes of sedentary individuals who had exhaustion test were investigated. Methods. A total of 20 men voluntarily participated in the study. Blood samples were obtained from participants on three conditions. First, before the study, blood samples of participants were collected (baseline). Second, the
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Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes J. Chem. (IF 3.0) Pub Date : 2023-9-12 Hassan Keypour, Mohammad Taher Rezaei, Saadat Hajari, Mahdi Jamshidi, Seyed Hamed Moazzami Farida
To synthesize new symmetrical macroacyclic Schiff base ligands (L1 and L2), polyamine (A) was condensed with 2-formylpyridine and salicylaldehyde. Furthermore, Ni(ClO4)2.6H2O and Zn(ClO4)2.6H2O in methanol were reacted with the ligands to prepare corresponding metal complexes. The cytotoxicity of the synthesized complexes against MCF-7 and A549 adenocarcinoma cells was evaluated, where Zn-complexes
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Benzylated Sulfamethoxazole Derivatives with Improved Safety Profile as Potential Anti-Mycobacterium tuberculosis and Antibacterial Agents J. Chem. (IF 3.0) Pub Date : 2023-9-12 Judas M. Maepa, Tlabo C. Leboho
This study focussed on the synthesis of sulfamethoxazole derivatives and their biological evaluation. The sulfamethoxazole derivatives were successfully biologically evaluated against Mycobacterium tuberculosis, Staphylococcus aureus, and Chinese Hamster Ovarian (CHO) cells. The biological evaluation revealed compounds with improved antitubercular activity and antibacterial activity against S. aureus
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An Overview of Structured Lipid in Food Science: Synthesis Methods, Applications, and Future Prospects J. Chem. (IF 3.0) Pub Date : 2023-9-9 Chi Rac Hong, Byeong Jun Jeon, Kyung-Min Park, Eun Ha Lee, Sung-Chul Hong, Seung Jun Choi
Structured lipids have attracted significant interest in industries, such as food, pharmaceuticals, and cosmetics, because they can be alternatives to traditional lipids. Enzymatic synthesis techniques utilizing lipases have gained attention for structured lipids synthesis because of their site and substrate specificity. However, most lipases discovered to date exhibit sn-1,3 regiospecificity or nonspecificity