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Recent Advances in Non‐Standard Macrocyclic Peptide Ligand Discovery using mRNA Display Isr. J. Chem. (IF 3.2) Pub Date : 2024-03-13 Yizhen Yin, Christopher John Hipolito
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Modulating the Acceptor Preference of His‐C‐Geranyltransferase LimF Isr. J. Chem. (IF 3.2) Pub Date : 2024-03-12 Yuchen Zhang, Yuki Goto, Hiroaki Suga
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The Transthyretin Protein and Amyloidosis – an Extraordinary Chemical Biology Platform Isr. J. Chem. (IF 3.2) Pub Date : 2024-03-06 Per Hammarström
The amyloidoses are diseases caused by accumulation of amyloid fibrils from over 40 different human misfolded proteins in various organs of the body depending on precursor protein. Amyloidogenesis is a self‐perpetuating reaction with deleterious consequences causing degeneration in cells and organs where depositions occur. Transthyretin, TTR, is an amyloidogenic protein causing sporadic disease from
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Deamination‐ or N‐nitrosation‐based methods for m6A Profiling Isr. J. Chem. (IF 3.2) Pub Date : 2024-03-04 Weiguo Shen, Jing Wang
The addition of various chemical modifications to RNA introduces an additional layer of complexity to the regulation of gene expression. Among all RNA modifications, N6‐methyladenosine (m6A) has earned its status as the most abundant and well‐studied post‐transcriptional modification in mammalian mRNA. Nevertheless, understanding the role of m6A in shaping the fate of RNA molecules and its influence
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RNA‐Guided RNA Pseudouridylation and 2’‐O‐Methylation Isr. J. Chem. (IF 3.2) Pub Date : 2024-02-27 Hironori Adachi, Jonathan L. Chen, W.‐Matthias Leeder, Pedro Morais, Yi‐Tao Yu
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Cellular Metabolic Labeling of Nucleic Acids and Its Applications Isr. J. Chem. (IF 3.2) Pub Date : 2024-02-23 Zhiyong He, Xiang Zhou
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Special Issue on Electrochemically-Driven Organic Synthesis Isr. J. Chem. (IF 3.2) Pub Date : 2024-02-22 Lutz Ackermann
Molecular synthesis has gained considerable momentum through the impetus provided by electrochemically-enabled redox manipulation.1 Organic electrosynthesis and electrocatalysis bear a unique potential to substantially improve molecular chemistry and provide a wide range of innovative transformations. While a first electrochemically-driven organic synthesis dates back to Kolbe's decarboxylative homocoupling
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The 4th Bowei Research Conference (BRC-4), January 3–5, 2024, Teachers′ Hostel, Sun Moon Lake, Taiwan Isr. J. Chem. (IF 3.2) Pub Date : 2024-02-21 Ehud Keinan
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Engineered RNA-binding Proteins: Studying and Controlling RNA Regulation Isr. J. Chem. (IF 3.2) Pub Date : 2024-02-16 Riley W. Sinnott, Yang Cao, Bryan C. Dickinson
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Structure-Activity Relationships of 2-(Arylthio)benzoic Acid FTO Inhibitors Isr. J. Chem. (IF 3.2) Pub Date : 2024-02-15 Chao Yan, Qian Zhang, Pan Xiao, Xinyun Xie, Ming Li, Yuanlai Qiu, Liufa Wen, Xiaomin Song, Ze Dong, Cai-Guang Yang
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Recent Advance in the Study on 5-Formylcytosine (f5C) RNA Modification Isr. J. Chem. (IF 3.2) Pub Date : 2024-02-12 Xin Wang, Xiao-Yang Jin, Liang Cheng
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Protein Glycosylation Patterns Shaped By the IRE1-XBP1s Arm of the Unfolded Protein Response Isr. J. Chem. (IF 3.2) Pub Date : 2024-02-05 Kenny Chen, Matthew D. Shoulders
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Pathogenicity Prediction of GABAA Receptor Missense Variants Isr. J. Chem. (IF 3.2) Pub Date : 2024-01-26 Ya-Juan Wang, Giang H. Vu, Ting-Wei Mu
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Nanopore Direct RNA Sequencing for Modified Uridine Nucleotides Yields Signals Dependent on the Physical Properties of the Modified Base Isr. J. Chem. (IF 3.2) Pub Date : 2024-01-26 Aaron M. Fleming, Justin C. Dingman, Yizhou Wu, Spencer S. Hoon, Cynthia J. Burrows
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Cystic Fibrosis Modulator Therapies: Bridging Insights from CF to other Membrane Protein Misfolding Diseases Isr. J. Chem. (IF 3.2) Pub Date : 2024-01-24 Minsoo Kim, Lars Plate
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A RaPID Response to SARS-CoV-2 Isr. J. Chem. (IF 3.2) Pub Date : 2024-01-24 Sven Ullrich, Christoph Nitsche
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30 years of semiconductor nanowire research: A Personal Journey Isr. J. Chem. (IF 3.2) Pub Date : 2024-01-19 Peidong Yang
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Decoding Skd3 (Human CLPB): a Mitochondrial Protein Disaggregase Critical for Human Health Isr. J. Chem. (IF 3.2) Pub Date : 2024-01-19 Ryan R. Cupo, James Shorter
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Advancing the Understanding of Surface Science through Nonlinear Optics and Electrochemistry Isr. J. Chem. (IF 3.2) Pub Date : 2024-01-10 Adi Salomon, Malachi Noked, Menny Shalom
Surface characterization is essential for understanding chemical and electrochemical transformations occurring on surfaces or at interfaces. Battery electrode aging processes, biofilm growth, crystallization, and transport/signaling across cellular membranes are only a few examples of such phenomena. This special issue delves into applied electrochemistry and nonlinear optical techniques applicable
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Tuning the Sign and Magnitude of Complexation-Induced pKa Shifts in Cucurbit[7]uril Host-Guest Complexes by Molecular Engineering Isr. J. Chem. (IF 3.2) Pub Date : 2024-01-09 Alberto Trevisan, Ana S. D. Ferreira, Philippe Marrec, A. Jorge Parola, Nuno Basílio
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Fabricating Quasiperiodic Tilings with Thermal-Scanning Probe Lithography Isr. J. Chem. (IF 3.2) Pub Date : 2023-12-11 Liam Chandler, Oliver J. Barker, Alexander J. Wright, Liam O'Brien, Sam Coates, Ronan McGrath, Ron Lifshitz, Hem Raj Sharma
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Quasicrystalline Antimony Thin Films Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-30 Hem Raj Sharma, Peter John Nugent, Sam Coates, Ronan McGrath
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In Memory of Prof. Richard A. Lerner Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-28
Dear Reader, This Special Issue has been put together to honor the life and work of Prof. Richard A. Lerner (August 28, 1938–December 2, 2021), whose visionary presidential leadership and guidance for over a quarter century (1987–2012) catapulted The Scripps Research Institute (La Jolla, California and Jupiter, Florida) into a powerhouse at the interface of chemistry, biology, and medicine. Following
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Richard A. Lerner: Memories and Reflections Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-28 Paul Schimmel
Richard Lerner was a singularity. During his tenure, Scripps Research was transformed into a biomedical powerhouse. He rapidly built remarkable strength in chemical and structural biology, immunology, cell and molecular biology, and molecular medicine. Not to stop there, he also instituted a new graduate program that consistently ranked in the top ten in the US. At the same time, he was a prolific
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STEM Structural Investigation of RE-Au-Si 1/1 Approximants Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-14 Wilfried Bajoun Mbajoun, Vinko Sršan, Yu-Chin. Huang, Girma Hailu Gebresenbut, Cesar Pay Gómez, Sylvie Migot-Choux, Jaafar Ghanbaja, Sašo Šturm, Vincent Fournée, Julian Ledieu
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Richard Lerner and the Birth of Antibody Libraries Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-15 Dennis R. Burton
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Richard A. Lerner – Little Known Facets of an Outstanding Man Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-15 Ehud Keinan
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Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-08 Jessica D. Rosarda, Caroline R. Stanton, Emily B. Chen, Michael J. Bollong, R. Luke Wiseman
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Recent Advances in Electrochemical Reductive Transformation of C−C and C−O Multiple Bonds Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-08 Atreyee Halder, Kingshuk Mahanty, Debabrata Maiti, Suman De Sarkar
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The Role of the Proteasome in Limiting Cellular Stress Associated with Protein Accumulation Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-07 Kate A. Kragness, Darci J. Trader
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Understanding and Overcoming Biochemical Diversity in AL Amyloidosis Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-06 Gareth J. Morgan
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Scanning Tunnelling Microscopy Studies of Tsai-Type Quasicrystal Approximants Isr. J. Chem. (IF 3.2) Pub Date : 2023-11-02 Sam Coates, Dominic Burnie, Hem Raj Sharma, Ronan McGrath
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A Quantitative Sequencing Method for 5-Formylcytosine in RNA Isr. J. Chem. (IF 3.2) Pub Date : 2023-10-16 Ruitu Lyu, Kinga Pajdzik, Hui-Lung Sun, Linda Zhang, Li-Sheng Zhang, Tong Wu, Lei Yang, Tao Pan, Chuan He, Qing Dai
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Quasicrystal Structure Prediction: A Review Isr. J. Chem. (IF 3.2) Pub Date : 2023-10-16 Michael Widom, Marek Mihalkovič
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The Cellular Environment Guides Self-Assembly and Structural Conformations of Microtubule-Associated Protein Tau (MAPT) Isr. J. Chem. (IF 3.2) Pub Date : 2023-10-09 Kelly M. Montgomery, Avi J. Samelson, Jason E. Gestwicki
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Surface Reactivity of the Au-Si-Ho Quasicrystalline 1/1 Approximant Isr. J. Chem. (IF 3.2) Pub Date : 2023-10-04 Wilfried Bajoun Mbajoun, Yu-Chin Huang, Girma Hailu Gebresenbut, Cesar Pay Gómez, Vincent Fournée, Julian Ledieu
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Π-acid catalysis – challenges, advances, and opportunities Isr. J. Chem. (IF 3.2) Pub Date : 2023-09-27 Yuri Tulchinsky, Ehud Keinan
Π-acid catalysis is one of the last two decades′ most exciting developments in synthetic organic chemistry. Because of the mild conditions employed and high functional group tolerance, π-acid catalysis became a tool of choice for the selective activation of double and triple C−C bonds at the late stages of multistep syntheses. At the same time, owing to the simplicity of the reaction setup, it also
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Recent Applications of Paired Electrolysis in Organic Synthesis Isr. J. Chem. (IF 3.2) Pub Date : 2023-09-27 Ke-Jin Jiao, Xiao-Tong Gao, Cong Ma, Ping Fang, Tian-Sheng Mei
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Electrochemical C7-Indole Alkenylation via Rhodium Catalysis Isr. J. Chem. (IF 3.2) Pub Date : 2023-09-25 Agnese Zangarelli, Binbin Yuan, Lutz Ackermann
The merger of rhodium catalysis and electrochemical synthesis enabled the exclusive access to the C7−H electro-alkenylation of indoles.
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Chemoenzymatic Tagging of Tn/TF/STF Antigens in Living Systems Isr. J. Chem. (IF 3.2) Pub Date : 2023-09-15 Yi Yang, Mingkuan Chen, Mengyao Wu, Senlian Hong, Bing Gao, Yonghui Liu, Chenhua Yu, Travis S. Young, Digantkumar Gopaldas Chapla, Jeong-Yeh Yang, John R. Cappiello, Jie P. Li, K. Barry Sharpless, Kelley W. Moremen, Peng Wu
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Calix[8]arene-Based Manganese Complexes for Electrocatalytic CO2 Reduction Isr. J. Chem. (IF 3.2) Pub Date : 2023-09-11 Armando Berlanga-Vázquez, Ivan Castillo
1 Introduction In nature, the reduction of CO2 is carried out by carbon monoxide dehydrogenase enzymes (CODHases).1 There are two known active sites: [Ni−Fe] from anaerobic bacteria and archea,2 and [Mo−Cu] from aerobic carboxydotrophic bacteria.3 Both enzymes catalyze reversibly the conversion of CO to CO2 in the presence of water as oxygen source. The metallic clusters operate in synergy with the
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Mechanochemical difluoromethylation of (thio)phenols and N-heterocycles Isr. J. Chem. (IF 3.2) Pub Date : 2023-09-13 Joseph Ford, Benjamin Hopkin, Jeroen B. I. Sap, Véronique Gouverneur
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Exploring the Sequence Space of Antimicrobial Peptide Dendrimers Isr. J. Chem. (IF 3.2) Pub Date : 2023-09-11 Xingguang Cai, Alice Capecchi, Basak Olcay, Markus Orsi, Sacha Javor, Jean-Louis Reymond
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Ferrocene as a Redox Catalyst for Organic Electrosynthesis Isr. J. Chem. (IF 3.2) Pub Date : 2023-08-23 Na Chen, Zheng-Jian Wu, Hai-Chao Xu
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Transition Metal-Catalyzed Electroreductive Cross-Couplings for C−C Bond Formation Isr. J. Chem. (IF 3.2) Pub Date : 2023-08-16 Meng-Yu Gao, Corinne Gosmini
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Protecting Group-Free Gold-Catalyzed Synthesis of 2-Acylidene-3-Oxindoles and Azaaurones via a Double Oxidation Strategy Isr. J. Chem. (IF 3.2) Pub Date : 2023-08-10 Xinlong Song, Ximei Zhao, Zhongyi Zeng, Frank Rominger, Matthias Rudolph, A. Stephen K. Hashmi
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Advances in Mass Spectrometry-Based Structural Proteomics: Development of HDX-MS and XL-MS Techniques from Recombinant Protein to Cellular Systems Isr. J. Chem. (IF 3.2) Pub Date : 2023-08-07 Valentine V. Courouble, Matthew D. Mann, Patrick R. Griffin
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New Frontiers in Gas Phase Chemistry and Catalysis. Celebrating the 80th Birthday of Helmut Schwarz Isr. J. Chem. (IF 3.2) Pub Date : 2023-07-31 Yitzhak Apeloig, Sason Shaik
Helmut Schwarz is a great scientist and a statesman who has made important fundamental contributions to chemistry as a science, and to the globalization of chemistry when he served as the Vice President of the German Research Foundation and subsequently as the President of the Alexander von Humboldt (AvH) Foundation.
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Mode-Selective Vibrational-Tunneling Dynamics in the N=2 Triad of the Hydrogen-Bonded (HF)2 Cluster Isr. J. Chem. (IF 3.2) Pub Date : 2023-07-31 Michael Hippler, Lars Oeltjen, Martin Quack
1 Introduction Much of chemical dynamics and kinetics is commonly understood with statistical theories such as transition state theory (TST) or the quasi-equilibrium theory (QET) of unimolecular fragmentation in mass spectra and related theories such as RRKM (Rice-Ramsperger-Kassel-Marcus) theory or the statistical adiabatic channel model (SACM). In these theories, which still govern the textbooks
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Redox-Responsive Macrocyclic Hosts Based on Calix[4]arene and Calix[4]resorcinarene Scaffolds Isr. J. Chem. (IF 3.2) Pub Date : 2023-08-02 Vladimir A. Azov, Francois J. De Beer
1 Introduction The term “calixarene” is broadly referred to the class of oligomeric macrocylic compounds composed of phenol-based aromatic units linked by C1 carbon bridges. This macrocycle class includes calix[n]arenes1, 2 in the strict sense of the word: the macrocycles comprising several phenols interconnected by simple methylene bridges; and closely related calix[4]resorcinarenes3, 4 (also commonly
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Catalytic Main-Group Metal Complexes of Phosphine-Based Pincer Ligands Isr. J. Chem. (IF 3.2) Pub Date : 2023-07-28 Michael Montag, David Milstein
1 Introduction In a seminal article from 1976, Moulton and Shaw reported the synthesis and characterization of several complexes obtained through the reaction of various late-transition-metal precursors with a previously unknown diphosphine compound, 2,6-bis[(di-tert-butylphosphino)methyl]phenyl (Figure 1a).1 Each of the resulting complexes featured the same tridentate anionic ligand, coordinated to
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Recent Advances in Electrochemical, Ni-Catalyzed C−C Bond Formation Isr. J. Chem. (IF 3.2) Pub Date : 2023-07-27 Mareena C. Franke, Daniel J. Weix
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Off/on Switching of Electric Current as a Strategy for One-Pot Synthesis of Bromoarylpyridines by Cross-Coupling/ C−H Bromination Isr. J. Chem. (IF 3.2) Pub Date : 2023-07-24 Yamato Hirota, Takaya Fujie, Takuya Kochi, Fumitoshi Kakiuchi
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Direct Electrooxidative Selenylamination of Alkynes: Access to 3-Selenylindoles Isr. J. Chem. (IF 3.2) Pub Date : 2023-07-24 Balati Hasimujiang, Yong Zeng, Shifeng Zou, Kaihui Zhong, Lebin Su, Xinwei Hu, Zhixiong Ruan
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Artificial Siderophores with a Trihydroxamate-DOTAM Scaffold Deliver Iron and Antibiotic Cargo into the Bacterial Pathogen Escherichia coli Isr. J. Chem. (IF 3.2) Pub Date : 2023-07-19 Isabell Schneider, Verena Fetz, Hans-Peter Prochnow, Mark Brönstrup
Introduction Infections with multidrug-resistant bacteria are a growing health care concern, recently coined as a ‘silent pandemic’.1 Antimicrobial resistance does not only impair chances of a successful cure of patients with community-acquired infections, but also puts achievements of modern medicine such as chemotherapy, organ transplantations or other procedures associated with increased infection
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Application of Naphthoquinone Derivatives Non-Covalently Modified Graphene Nanosheets in Asymmetric Supercapacitors Isr. J. Chem. (IF 3.2) Pub Date : 2023-07-12 Lijie Hou, Chao Kong, Zhongai Hu, Yanxia Han, Bowan Wu