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Submonomer synthesis of inverse polyamidoamine (i‐PAMAM) dendrimer antibacterials Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-14 Hippolyte Personne, Xiaoling Hu, Etienne Bonvin, Jérémie Reusser, Jean-Louis Reymond
Herein we report that the submonomer method for peptoid synthesis enables access to pure i‐PAMAM dendrimers up to 16 amino termini by a divergent solid‐phase synthesis using the inexpensive bis(3‐trifluoroacetamidopropyl)amine as branching unit. We exemplify this new and efficient approach by a structure‐activity relationship study of antibacterial dendrimers obtained by appending the polycationic
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Does the central nitrogen atom make a difference? A comparison of non‐coordinating pyridine and benzene spacers in multitopic ligands Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-14 Catherine E. Housecroft, Edwin Charles Constable
In metal coordination compounds of the divergent ligands 4,2':6',4"‐terpyridine and 3,2':6',3"‐terpyridine and their 4'‐functionalized derivatives, the central pyridine ring of the 4,2':6',4"‐terpyridine and 3,2':6',3"‐terpyridine domains is non‐coordinated. We present an overview of data from the Cambridge Structural Database to assess whether there are structural similarities between the coordination
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Protocol for the Photocatalytic Hydroxyalkenylation of Alkenes Using 1,2‐Bis(phenylsulfonyl)ethylene and Water Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-13 Chen-Yang Tsai, Chun-Yu Chen, Yen-Ku Wu, Ilhyong Ryu
We report on a protocol for the hydroxyalkenylation of alkenes using an acridinium photoredox catalyst in combination with 1,2‐bis(phenylsulfonyl)ethylene and water. Using the protocol, alkenes could be converted into the corresponding 1‐phenylsulfonyl‐4‐hydroxyalkenes in good yields. The hydroxyalkenylation involves the nucleophilic hydroxylation of alkene‐derived radical cations to give β‐hydroxyalkyl
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A Targeted Approach for the Metabolome Analysis of E. coli Biofilms Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-09 Jan Rockstroh, Sandy Gerschler, Nadin Schultze, Christian Schulze, Martina Wurster, Karen Methling, Sebastian Guenther, Michael Lalk
Biofilms of pathogenic bacteria are responsible for persistent infections in humans, therefore investigations of biofilm formation and treatment strategies are required. The gram‐negative enterobacterium Escherichia (E.) coli is the most common pathogen causing chronic or recurring urinary tract infections. Metabolomics approaches targeted the bacterium to investigate specific metabolic patterns of
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Organocatalytic Enantioselective Synthesis of Chiral Spiro‐indoline‐pyrazolones through a formal [4+1] Annulation Reaction of 4‐Bromopyrazolones and aza‐ortho‐Quinone Methides Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-06 Laura Carceller-Ferrer, Carlos Rodríguez-Arias, Marc Montesinos-Magraner, Amparo Sanz-Marco, Judit Hostelet-Romero, Gonzalo Blay, José R. Pedro, Carlos Vila
In this communication, a straighforward asymmetric synthesis of spiro‐indoline‐pyrazolone compounds is described. This methodology consists in a formal [4+1] cycloaddition reaction of 4‐bromopyrazolones and aza‐ortho‐quinone methides generated in situ catalyzed by a bisquinine‐derived squaramide in CHCl3 under basic conditions. A variety of chiral spirocyclic compounds bearing a pyrazolone and an indoline
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A Fluorogenic Substrate for Quinoline Reduction: Pnictogen‐Bonding Catalysis in Aqueous Systems Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-06 Giacomo Renno, Qing-Xia Zhang, Antonio Frontera, Naomi Sakai, Stefan Matile
It is often said that pnictogen‐bonding catalysis, and s‐hole catalysis in general, would not work in aqueous systems because the solvent would interfere as an overcompetitive pnictogen‐bond acceptor. In this study, we show that the transfer of pnictogen‐bonding catalysis from hydrophobic solvents to aqueous systems is possible by replacing only hydrophobic with hydrophilic substrates, without changing
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Manganese‐Mediated Synthesis of NHC‐Phosphine Ligand Precursors Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-05 Yves Canac, Jérémy Willot, Sana Fatima, Carine Duhayon, Noël Lugan, Dmitry A. Valyaev
Alkylation of N‐substituted imidazoles ImR’ (R’ = 2,4,6‐trimethylphenyl, 2,6‐diisopropylphenyl, 1‐adamantyl) with Mn(I) methylenephosphonium complexes [Cp(CO)2Mn(η2‐P,C‐R2P=C(H)Ph)](BF4) (PR2 = PPh2, PCy2, trans‐PC(H)PhCH2CH2C(H)Ph) followed by photochemical demetallation afforded a series of bidentate NHC‐phosphine ligand precursors [R2PC(H)PhImR’](BF4) in moderate to good yield. The same strategy
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Evolution of the Manufacturing Route towards a Key Benzothiophen‐2‐yl‐Boronic Acid Building Block of Rogaratinib Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-04 Holger Paulsen, Jörg Gries, Johannes Platzek
The evolution of the synthesis of a benzothiophene‐2‐yl‐boronic acid ‐ a key building block for the anti‐cancer agent Rogaratinib ‑ is reported from multi‐gram scale to industrialization. The pitfalls and learnings during process development are outlined, describing the optimization of the initial research synthesis route, investigation of an alternative approach based on a palladium‐catalyzed Newman‐Kwart
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Revealing the Indispensable Role of the RFamide Functionality using a Novel Acid Labile Benzofuranone based Amine (ALBA) Linker Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-25 Gemma Mudd, Megan Hendrikse, Steven Shave, Douglas R Houston, Robert P Millar, Manfred Auer
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Synthesis and Quantitative Analysis of Glycans Conjugated to Gold Nanoparticles Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-20 Kuo-Shiang Liao, Chih-Chuan Kung, Li-Chun Cheng, Cinya Chung, Chi-Huey Wong
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Andrea Vasella and the Active Site of Glycoside Hydrolases Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-19 Roland Hoos-Michelotti
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New Selective Inhibitors of α-Glucosidase for the Treatment of Type 2 Diabetes Mellitus Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-14 Takwa Khanchouch, Aurélie Vallin, Urjwan Alali, Mohammed Benazza, Rym Abidi, Véronique Bonnet
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N-Methyl-N-Alkylaminocyclopentanes: Powerful and Selective β-d-Glucocerebrosidase Inhibitors Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-13 Patrick Weber, Roland Fischer, Seyed A. Nasseri, Bettina M. Pabst, Herwig Prasch, Arnold E. Stütz, Martin Thonhofer, Stephen G. Withers, Werner Windischhofer, Tanja M. Wrodnigg
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Development of a Novel Measurement Setup to Study and Predict Electrostatic Discharges in Agitated Glass-Lined Vessels Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-12 Benedikt Robert Brönnimann, Daniel Egli-Tedesco, Klaus Schwenzfeuer, Andreas Zogg
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Benzylic C(sp3)−H Azidation: Copper vs Iron Catalysis Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-09 Angel Rentería-Gómez, Rubén O. Torres-Ochoa, Pierre Palamini, Raphaël Simonet-Davin, Qian Wang, Jérôme Waser, Jieping Zhu
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Design and Synthesis of Dialkylarylphosphine Urea Ligands and their Application in Palladium-Catalyzed Cross-Coupling Reactions Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-09 Lupita S. Aguirre, Levi T. Litwiller, Alexis N. Lugo, Andy A. Thomas
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Functionalization of Cubane Formation of C−C and C−Heteroatom Bonds Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-02 Tomohiro Yasukawa, Katja S. Håheim, Janine Cossy
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A Scalable and Chromatography-Free Synthesis of N,N-Bis(9,9-dimethyl-9H-fluoren-2-yl)-3′,3′,4′,7′-tetramethyl-2′,3′-dihydrospiro[fluorene-9,1′-indene]-2-amine, a new Hole Transport Material for Organic Solar Cells Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-02 Yves Aeschi, Thorsten M. Beck, Ulrich Berens, Alexander Ernst
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Novel Rearrangements of Guaiane Sesquiterpenes Helv. Chimica Acta (IF 1.8) Pub Date : 2024-01-29 Paul L. Türtscher, Gerhard Brunner, Andreas Goeke
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Synthesis and Cell-Based Evaluation of Umifenovir Analogues as Anti-SARS-CoV-2 Agents Helv. Chimica Acta (IF 1.8) Pub Date : 2024-01-18 Hiroaki Tanaka, Seiya Miyagi, Tomoko Morita, Hiroaki Ishii, Natsuki Mori, Kaho Oishi, Takemasa Sakaguchi, Toyonobu Usuki
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Enhancing the Metalating Power of ZnEt2 via Formation of an Alkyl/Alkoxide Potassium Zincate Helv. Chimica Acta (IF 1.8) Pub Date : 2024-01-12 Jasmin Kocher, Neil R. Judge, Eva Hevia
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Selective Recognition of Aromatic Amino Acids by a Molecular Cleft in Water Helv. Chimica Acta (IF 1.8) Pub Date : 2024-01-10 Joël F. Keller, Michal Valášek, Marcel Mayor
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Synthesis and Photophysical Evaluation of 3,3’-Nitrogen Bis-Substituted fac-[Re(CO)3(Diimine)Br] Complexes Helv. Chimica Acta (IF 1.8) Pub Date : 2024-01-09 Joshua Csucker, Nathalie Decrausaz, Sarah Isabella Jäggi, Olivier Blacque, Bernhard Spingler, Roger Alberto
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Chiral Quaternary Ammonium Salt-Catalyzed Enantioselective Addition Reactions of Hydantoins Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-28 Katharina Röser, Lucas Prameshuber, Sajid Jahangir, Sharath Chandra Mallojjala, Jennifer S. Hirschi, Mario Waser
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Radicals and Carbohydrates: A Grand Alliance Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-21 Béatrice Quiclet-Sire, Samir Z. Zard
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Playing with Protic Additives to Improve the Outcome of Rhodium-Catalyzed Hydroarylation of Fullerene C60 with Arylboronic Acids Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-15 Merve Ergun Dönmez, Måns Eriksson, Gustav Hulu, Michael Nordström, Helena Grennberg
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Strategies for Direct, Transition Metal-Free Addition of Nitrogen Synthons to Alkenes Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-15 Brett N. Hemric, Thalia A. Garcia, Adriana E. Barni
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Hydroalkylation of 1,1-Diarylalkenes Mediated by Magnesium Hydride in Ethereal Solvents Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-14 Nattawadee Chaisan, Eugene Yew Kun Tan, Shunsuke Chiba
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Twofold Alkenylation of Thiophenes with N-Vinylcarbazole via Iron-Catalyzed Regioselective C−H/C−H Coupling Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-12 Takahiro Doba, Rui Shang, Eiichi Nakamura
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Alternative Routes to 4,6-O-Benzylidene β-Thioglycosides Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-11 Daniela Imperio, Filippo Valloni, Luigi Panza
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A Special Issue Dedicated to Professor Andrea Vasella Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-06 Karin Briner, Werngard Czechtizky, Thomas Storz, Bruno Bernet, Roland Bürli, Alexander Ernst
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Thirty-Three Years Member of the Group Vasella by Bruno Bernet Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-06 Bruno Bernet
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Steric Bulk-Dependent Photoresponse of Sulfonamide Azobenzene Ligand in Arene Ruthenium(II) Complexes Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-01 Jonathan Long, Pascal Retailleau, Juan Xie, Nicolas Bogliotti
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Probing the Nature of Surface Hydrides by Deuterium Quadrupolar Parameters: A Case Study on Silica-Supported Zirconium Hydrides Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-23 Scott R. Docherty, Philipp Schärz, Domenico Gioffrè, Alexander V. Yakimov, Christophe Copéret
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HFIP Mediated Synthesis of C4-Aryl-2-quinolones through Serial Oxidation Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-21 Seung Hoon Lee, Minseok Kang, Hyung Min Chi
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Development of Photoredox-Assisted Direct α-Alkylation Reactions of Ketones with Arylalkenes Using a Catalytic Amount of LiOtBu as a Brønsted Base Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-20 Tsubasa Hirata, Tomoya Hisada, Yoshihiro Ogasawara, Shū Kobayashi, Yasuhiro Yamashita
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Scalable Preparation of 1-Aminoethyl Oxindoles From Simple Benzaldehydes Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-16 Cédric Bürki, Stefan Diethelm, Fabio D'Aiuto, Marco Künzli, Gaëlle Mathieu, Christine Schmitt
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Improved Synthesis of Chiral 1,4,7-Triazacyclononane Derivatives and Their Application in Ni-Catalyzed Csp3−Csp3 Kumada Cross-Coupling Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-15 Chi-Herng Hu, Ju Byeong Chae, Liviu M. Mirica
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Synthesis and Olfactory Properties of Lower-Ring Homologues of the Linear Alicyclic Musk Romandolide Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-14 Vladimír Dacho, Artem Nikipelov, Michaela Tóthová, Philip Kraft, Peter Szolcsányi
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Keap It in the Family: How to Fish out New Paradigms in Keap1-Mediated Cell Signaling Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-13 Marcus J. C. Long, Kuan-Ting Huang, Yimon Aye
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Tailoring the Hybridization Density of DNA Biosensors through Tunable Surface Functionalization Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-13 Perrine Robin, Lucas Mayoraz, Pauline Skigin, Mounir Mensi, Sandrine Gerber-Lemaire
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A Practical and Scalable Non-Photonic Decarboxylative C−N Coupling of Bicyclo[1.1.1]Pentane Carboxylate by Leveraging High Throughput Experimentation Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-04 Nathan J. Gesmundo, Lei Shi, Russell C. Smith
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Scalable Preparation of 1-Aminoethyl Substituted Chromanes Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-03 Stefan Diethelm, Gunther Schmidt, Thierry Sifferlen, Amandine Boller, Laurent Cornu, Christine Schmitt
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Prediction of Reaction Performance by Machine Learning Using Streamlined Features: NMR Chemical Shifts as Familiar Descriptors Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-27 Su-min Song, Ha Eun Kim, Hyun Woo Kim, Won-jin Chung
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A Multiplex GPCR-Mediated Peptide Tagging System for a Growing Yeast Synthetic Biology Toolbox Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-22 Joseph Matragrano, Virginia W. Cornish, Sonja Billerbeck
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Dynemicin A Derivatives as Potential Cancer Chemotherapeutics by Mutasynthesis Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-21 Paramita Pal, Jamie R. Alley, Douglas R. Cohen, Craig A. Townsend
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Kilogram-Scale Synthesis of 4-Chloro-6-(6-methoxypyridin- 3-yl)pyrimidine through a Suzuki–Miyaura Cross-Coupling Using Micellar Catalysis Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-18 Nicholas A. Isley, Fabrice Gallou
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Optimizing Phosphate Couplings for Dolichyl Diphosphochitobiose to Enable Protein N-Glycosylation Studies Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-13 Matheus A. Meirelles, Jean-Louis Reymond
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Development of a 2nd Generation Process for 3-Ethyl-4-Hydroxy-5-Methylbenzonitrile – A Key Building Block of S1P1 Receptor Modulator Cenerimod – through a Non-Classical Nitrile Formation Using Hydroxylamine-O-sulfonic Acid (HOSA) Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-11 Gabriel Schäfer, Tony Fleischer
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Introduction for the Special Collection of Papers in the Honor of Robert Deschenaux. Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-04 Jean-François Nierengarten, Jean-Marie Lehn
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iso-Fatty Acid Metabolism in Caenorhabditis elegans’ Ceramide Biosynthesis Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-02 Rocío Rivera Sánchez, Siva Bandi, Marie-Désirée Scheidt, Hanna Laaroussi, Bennett William Fox, Yojiro Ishida, Gaétan Glauser, Sylvain Sutour, Stephan H. von Reuss
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Enantio- and Diastereoselective (Ipc)2BOTf-Mediated Aldol Reactions of Morpholine Carboxamides Helv. Chimica Acta (IF 1.8) Pub Date : 2023-09-29 Lee Pedzisa, Andrii Monastyrskyi, Camille D. Parker, William R. Roush
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Synthesis of {CB11} Monocarborane Sulfonamides by B2-Selective Rhodium-Catalyzed B−H Activation Helv. Chimica Acta (IF 1.8) Pub Date : 2023-09-28 Zehua Ye, Jizeng Sun, Yujie Jin, Chuhao Lin, Jiyong Liu, Simon Duttwyler
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The Honeysuckle and the Bindweed Revisited: Synthesis and Stereochemistry of Extended Helical Structures from Coordination Complexes Helv. Chimica Acta (IF 1.8) Pub Date : 2023-09-28 Alan M. Downward, Matteo Granelli, Celine Besnard, Laure Guénée, Alan F. Williams
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Construction of Cyclobutane-Centered Tricyclic Caged Skeleton through a [5,5]-Rearrangement Triggered Cascade Helv. Chimica Acta (IF 1.8) Pub Date : 2023-09-28 Mengjie Hu, Mengjiao Zhu, Liying Ru, Jiangtao Ji, Ming Bao, Bo Peng
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Rapid Synthesis of Propargyl-γ-Modified Peptide Nucleic Acid Monomers for Late-Stage Functionalization of Oligomers Helv. Chimica Acta (IF 1.8) Pub Date : 2023-09-27 Miguel López-Tena, Emma E. Watson, Patrick Romanens, Nicolas Winssinger
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β-Silylacrylate as a Multipurpose Reagent in Organic Synthesis Helv. Chimica Acta (IF 1.8) Pub Date : 2023-09-25 Sunil K. Ghosh