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Regioselective C3-Formylation of 2H-Indazoles Using Selectfluor under Microwave-Assisted Conditions SynOpen Pub Date : 2024-03-04 Manivel Pitchai, Mahammed Kaspady, Gopikumar Indasi, Rajesh Krishnan, Gururaju Sannakki Maheswarappa, Muthalagu Vetrichelvan, Arvind Mathur, Anuradha Gupta
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Synthesis of 3,4-Disubstituted Pyrroline Nitroxides Containing Diphenylphosphane or Diphenylphosphane Oxide Substituents SynOpen Pub Date : 2024-03-01 Áron Balázsi, Balázs Bognár, József Jekő, Tamás Kálai
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Cobalt–Magnesium and Cobalt–Calcium Heterotrimetallic Dinitrogen Complexes SynOpen Pub Date : 2024-02-29
We report the use of alkaline earth metals magnesium and calcium for the reduction of the cobalt(II) complex [ i Pr2NN]Co(μ-Cl)2Li(thf)2 [ i Pr2NN = 2,4-bis(2,6-diisopropylphenylimido)pentyl] that resulted in heterotrimetallic dinitrogen complexes with a rare example of a [Co–N2–M–N2–Co] core where M = Mg and Ca. The dinitrogen ligands in these new complexes showed weakened N–N bonds, as judged by
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An Overview of Synthetic Approaches towards 1,2,3-Triazoles SynOpen Pub Date : 2024-02-13 Yajat Rohila, Sharol Sebastian, Meenaskhi Meenaskhi, Manoj K. Gupta
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Synthesis of C-Glucoside Analogues of Naturally Occurring Phenylethanoid O-Glucosides SynOpen Pub Date : 2024-01-25 Amudala Subramanyam, Sumit Sumit, Indrapal S. Aidhen
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tert-Butoxide-Mediated Protodeformylative Decarbonylation of α-Quaternary Homobenzaldehydes SynOpen Pub Date : 2024-01-19 Benjamin J. Stokes, Xiao Cai, Ritter V. Amsbaugh, Lauren J. Drake, Ravi M. A. Kotamraju, Nicholas Javier C. Licauco
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Synthesis of a Propellane-Type 5/5/6-Tricyclic System by Tandem-Metathesis: A New Approach to a Quadranoid Skeleton SynOpen Pub Date : 2024-01-17 Sambasivarao Kotha, Ramakrishna Reddy Keesari
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Synthesis of Bioactive 1,2,3-Triazole-Fused Macrocycles via Azide-Alkyne Cycloaddition SynOpen Pub Date : 2024-01-04
A systematic highlight of syntheses reported since 2006 of 1,2,3-triazole-fused macrocycles possessing biological activities such as anticancer, antibacterial, antiviral, anti-inflammatory and antilarval action, is presented in this review. The well-renowned Cu-catalyzed azide-alkyne cycloaddition reaction was noted to be highly efficient and is one the most common methods utilized by scientists for
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Oxidation of Alcohols to Aldehydes and Ketones Using a Catalytic Pairing of a Nitroxide and Nitric Acid SynOpen Pub Date : 2023-12-21 Manisha Sharma, Arturo León Sandoval, Nicholas E. Leadbeater
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Low Molecular Weight Supramolecular Allobetuline-, Cyclohexanol-, or Undecanol-Appended 1,2,3-Triazole-Based Gelators: Synthesis and Molecular Dynamics Simulation Study SynOpen Pub Date : 2023-12-18 Victoria Lipson, Oleg Zhikol, Svetlana Shishkina, Alexander Semenenko, Karina Kulyk, Pavel Mateychenko, Vladimir Musatov, Alexander Mazepa, Vladimir Vakula, Alexander Borisov, Alexander Kyrychenko
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Recent Developments in the Detection of Zn2+ Ions Using Schiff Base Probes SynOpen Pub Date : 2023-12-18 Ram Kumar, Bholey Singh, Shwetank Shashi Pandey, Balaram Pani
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New Synthesis of 3-Aminohydantoins via Condensation of Hydrazines with Isocyanates Derived from α-Amino Esters SynOpen Pub Date : 2023-12-11 Houda Bouchnak, Thierry Ollevier, Jamil Kraïem
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Truly Catalytic Gewald Synthesis of 2-Aminothiophenes Using Piperidinium Borate (Pip Borate), a Conjugate Acid–Base Pair SynOpen Pub Date : 2023-11-23
The Gewald reaction has been well-known for more than half a century as an excellent method to provide bioactive 2-aminothiophene heterocycles from the reaction of carbonyl compounds, α-cyanoacetates, and elemental sulfur, in the presence of amines, in stoichiometric amounts. This work describes the use of salts of boric acid as conjugate acid-base pairs in a truly catalytic amount for the cyclocondensation
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Gum Acacia Stabilized Ag-TiO2 and Ag-SiO2: Sustainable Nanocatalysts for Direct and Convenient Synthesis of 5-Substituted 1H-tetrazoles SynOpen Pub Date : 2023-11-23 Supriya Prakash, Bojja Sreedhar, N. V. S. Naidu
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A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications SynOpen Pub Date : 2023-11-22 Leqaa A. Mohammed, Mohammed Alwan Farhan, Safaa A. Dadoosh, Mustafa A. Alheety, Abdulwahhab H. Majeed, Ali Saadon Mahmood, Zaid H. Mahmoud
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A Facile, Mechanochemical, Solvent-, and Catalyst-Free Synthesis of Functionalized 4-Thiazolidinones SynOpen Pub Date : 2023-11-16
A highly eco-friendly greener approach based on the mechanochemical method using mortar and pestle is explored for the preparation of a variety of functionalized 4-thiazolidinones. The developed methodology does not require the use of harmful or expensive reagents and organic solvents and requires very less reaction time with easy isolation. The explored greener approach for the synthesis of 4-thiazolidinones
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Recent Advances in the Synthesis of 2-Hydroxy-1,4-naphthoquinone (Lawsone) Derivatives SynOpen Pub Date : 2023-11-16 Ram Sagar, Uma Shankar, Ashish Khanna, Kavita Singh, Ghanshyam Tiwari
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A Decade of Exploration of Transition-Metal-Catalyzed Cross-Coupling Reactions: An Overview SynOpen Pub Date : 2023-11-13 Saurav Kumar, Jyoti Jyoti, Deepak Gupta, Gajendra Singh, Anil Kumar
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Exploring the Catalytic Efficiency of Copper-Doped Magnetic Carbon Aerogel for the Coupling Reaction of Isatin Oxime with Phenylboronic Acid Derivatives SynOpen Pub Date : 2023-11-09 Deeksha Mudgal, Ravi Pratap Singh, Nisha Yadav, Tapeesh Bharti, Vivek Mishra
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Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium (HATU): A Unique Cross-Coupling Reagent SynOpen Pub Date : 2023-11-06 Abhimannu Shome, Keshav Taruneshwar Jha, Pooja A. Chawla
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The Catalyst’s Companion: N,N′-Dicyclohexylcarbodiimide (DCC) in Action SynOpen Pub Date : 2023-11-02 Arshdeep Singh, Anjali Sharma, Pooja A. Chawla
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Chlorophyll: A Greener Catalyst in Synthetic Transformations SynOpen Pub Date : 2023-10-30 Simranpreet K. Wahan, Gaurav Bhargava, Pooja A. Chawla
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Sodium Periodate (NaIO4) in Organic Synthesis SynOpen Pub Date : 2023-10-26 Ravi Varala, Narsimhaswamy Dubasi, Vittal Seema, Vijay Kotra
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Improved Synthesis of Unsymmetrical Ureas via Carbamates SynOpen Pub Date : 2023-10-26 Ramteke Prachi, Dinesh Kumar Tanwar, Manjinder Singh Gill
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Oxidative C–H Sulfonylation of Hydrazones Enabled by Electrochemistry SynOpen Pub Date : 2023-10-25 Qi-Liang Yang, Ping-Ping Lei, Er-Jun Hao, Bei-Ning Zhang, Hong-Hao Zhou, Wan-Wan Li, Hai-Ming Guo
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Electrochemical Synthesis of Organoselenium Compounds: A Graphical Review SynOpen Pub Date : 2023-10-24 Balati Hasimujiang, Zhixiong Ruan
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Recent Advances in Electrochemically Mediated Reactions of Diselenides SynOpen Pub Date : 2023-10-24 Lei Zhan, Qian Wang, Hai-Tao Tang, Zu-Yu Mo, Ying-Ming Pan
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Application of N-Bromosuccinimide in Carbohydrate Chemistry SynOpen Pub Date : 2023-10-19 Smritilekha Bera, Dhananjoy Mondal, Bhaskar Chatterjee
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Direct Electrochemical C(sp3)–H Amidation Enabled by Hexafluoroisopropanol (HFIP) SynOpen Pub Date : 2023-10-18 Fengyi Li, Ke Liu, Qi Sun, Sheng Zhang, Man-Bo Li
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Cost-Effective and Scalable Synthesis of 4-Bromo-1,2-dimethyl-1H-imidazole: A Key Building Block for Bioactive Molecules SynOpen Pub Date : 2023-10-18
A cost-effective, scalable, high-yielding, and commercially viable synthesis of 4-bromo-1,2-dimethyl-1H-imidazole (1), an important building block to construct various bioactive molecules has been established. The main feature of this method includes the selection of appropriate starting material 1,2-dimethyl-1H-imidazole in which the existing issue of regioisomer formation is circumvented and the
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Synthesis and Characterization of an Eight-Membered Heterocyclic 1,3,5,7-Tetra(3-pyridyl)-1,3,5,7-tetrazacyclooctane SynOpen Pub Date : 2023-10-16
N,N′-Bis(3-pyridyl)methanediamine was prepared by treating 3-aminopyridine with formaldehyde in acetonitrile. By treating it with formaldehyde, the eight-membered heterocyclic ring compound 1,3,5,7-tetra(3-pyridyl)-1,3,5,7-tetrazacyclooctane was prepared. This could occur in a two-step manner in a [3+1+3+1] cycloaddition reaction. The compounds were characterized by X-ray crystallography, 1H and 13C
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Half-Sandwich d6-Metal (CoIII, RhIII, IrIII, RuII)-Catalyzed Enantioselective C–H Activation SynOpen Pub Date : 2023-10-05 Pu-Fan Qian, Jun-Yi Li, Yi-Bo Zhou, Tao Zhou, Bing-Feng Shi
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Synthetic Utility of N-Acylbenzotriazoles SynOpen Pub Date : 2023-09-27 Mangal S. Yadav, Abhishek Gupta, Priyanka Bose, Anoop S. Singh, Prabhu P. Mohapatra, Vinod K. Tiwari
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A Practical and Efficient Method for the Synthesis of Sorafenib and Regorafenib SynOpen Pub Date : 2023-09-26 Ramteke Prachi, Manjinder Singh Gill
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Pyrrolidinium Acetate (PyrrIL) as a Green and Recyclable Catalyst: Synthesis of 2-Phenyl Benzimidazoles and 2-Phenyl Benzothiazoles under Solvent-Free Conditions at Room Temperature SynOpen Pub Date : 2023-09-08
Benzimidazoles and benzothiazoles are a class of pharmacologically potential compounds, which exhibited antimicrobial, anticancer, and anti-inflammatory activities. These can be obtained by simple condensation of o-phenylenediamine or o-aminothiophenol with aromatic aldehydes. The synthetic protocol can be accomplished/improved by varying reaction parameters such as temperature, solvents, and catalysts
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Recent Applications of TEMPO in Organic Synthesis and Catalysis SynOpen Pub Date : 2023-09-07
In this spotlight article, authors highlighted the applications of TEMPO in organic synthesis and catalysis starting from 2015 to date.
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Synthesis of Squaric Acid Monoamides as Building Blocks for Drug Discovery SynOpen Pub Date : 2023-08-29 Nathan Long, Adam Le Gresley, Arran Solomonsz, Antony Wozniak, Steve Brough, Stephen P. Wren
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Synthesis of Novel Phosphorus-Substituted Stable Isoindoles by a Three-Component Coupling Reaction of ortho-Phthalaldehyde, 9,10-Dihydro-9-oxa-10-phosphaphenanthrene 10-Oxide, and Primary Amines SynOpen Pub Date : 2023-08-28 Michiyasu Nakao, Akihito Nakamura, Tomoyuki Takesue, Syuji Kitaike, Hiro-O Ito, Shigeki Sano
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Synthesis of the Key Saccharide Fragments of the Glucuronic Acid-Containing Repeat Unit of Pentosan Polysulfate, a Heparin Sulfate Mimetic SynOpen Pub Date : 2023-08-21 Martin G. Banwell, Sarah Marshall, Jas S. Ward, Brett D. Schwartz
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Sustainable Organocatalyzed Enantioselective Catalytic Michael Additions in Betaine-Derived Deep Eutectic Solvents SynOpen Pub Date : 2023-08-17 Daniela P. Fonseca, Ana C. Amorim, Elisabete P. Carreiro, João P. Prates Ramalho, Gesine J. Hermann, Hans-Jürgen Federsel, Ana Rita C. Duarte, Anthony J. Burke
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Copper Sulfate (CuSO4): An Efficient Reagent in Organic Synthesis SynOpen Pub Date : 2023-08-15 Housemberg D. S. Ferrreira, Euzébio G. Barbosa, Alessandro K. Jordão
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Multi-step Flow Synthesis of the Anthelmintic Drug Praziquantel SynOpen Pub Date : 2023-08-14 Manjinder Singh Phull, Surender Singh Jadav, Chander Singh Bohara, Rambabu Gundla, Prathama S Mainkar
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Recent Advances in the Synthesis of Bioactive Glycohybrids via Click-Chemistry SynOpen Pub Date : 2023-08-10 Kavita Singh, Rajdeep Tyagi, Vinay Kumar Mishra, Ghanshyam Tiwari, Ram Sagar
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DMSO arbitrated Oxidative Annulation Followed by Homologated N-Alkylation: Microwave-Assisted Efficient and Greener Approach to Access 3-(3-Oxo-3-arylpropyl) Quinazolinones SynOpen Pub Date : 2023-08-08 A. V. G. Prasanthi, Bathini Nagendra Babu
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Green Synthesis of Pyrazoles: Recent Developments in Aqueous Methods SynOpen Pub Date : 2023-08-07 Sushma Singh, Sidhant Yadav, Minakshi Minakshi, Rashmi Pundeer
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Ziegler–Natta Catalysts: Applications in Modern Polymer Science SynOpen Pub Date : 2023-07-26 Keshav Taruneshwar Jha, Abhimannu Shome, Pooja A Chawla
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Boric Acid: A Mild and Efficient Green Catalyst for Organic Transformations SynOpen Pub Date : 2023-07-20 Amit Kumar Rawat, Pradeep Kumar, Preetam Kumar, Kamal Singh
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Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications SynOpen Pub Date : 2023-06-19 Smritilekha Bera, Dhananjoy Mondal
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Electrochemical/I– Dual-Catalyzed Access to Sulfonated Pyrazoles under External Oxidant-Free Conditions SynOpen Pub Date : 2023-06-07 Jing Ma, Jianjing Yang, Kelu Yan, Boju Luo, Kexin Huang, Ziling Wu, Yumeng Zhou, Shuyun Zhu, Xian-En Zhao, Jiangwei Wen
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Recent Applications of Hexamethyldisilathiane (TMS2S) in Organic Synthesis SynOpen Pub Date : 2023-06-05 Damien Hazelard, Philippe Compain
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Temperature-Controlled Diastereoselective Doebner/Ugi Tandem Reaction SynOpen Pub Date : 2023-05-31 Yana Sakhno, Oleksandr Radchenko, Vyacheslav Saraev, Yuliia Shliapkina, Mariia Kaidash, Mariia Shyshkina, Svitlana Shishkina, Vladimir Musatov, Sergey Desenko, Valentyn Chebanov
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Synthesis of Bioactive Macrocycles Involving Ring-Closing Metathesis Strategy SynOpen Pub Date : 2023-05-23 Nasrin Jahan, Inul Ansary
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Recent Developments in Ultrasound-Promoted Aqueous-Mediated Greener Synthesis of Biologically Vital Indole Derivatives SynOpen Pub Date : 2023-05-24 Kanaram Choupra, Ashish Kumar Aheer, Anshu Dandia, Meenakshi Jain, Amit Sharma
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Recent Advancements in Triazole-based Click Chemistry in Cancer Drug Discovery and Development SynOpen Pub Date : 2023-05-17 Arun Kumar, Ashok Kumar Yadav, Vivek Mishra, Deepak Kumar
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Chemical Reactions of Indole Alkaloids That Enable Rapid Access to New Scaffolds for Discovery SynOpen Pub Date : 2023-05-11 Derek A. Leas, Daniel C. Schultz, Robert W. Huigens III
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Highly Efficient Synthesis of 3,3-Disubstituted Oxindoles through Direct Oxidative Alkylarylation of N-Arylacrylamides with Simple Alkanes SynOpen Pub Date : 2023-05-08 Yan Chen, Weihong Song, Zhixiang Zhou, Ziye Zhang, Kai Liu, Xiaofei Zeng, Xiaoyu Han
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Conversion of α-Diazoketones into 1-Bromo-2-alkyl- or 2-arylpent-4-en-2-ols using Tin-Mediated Allylation/Propargylation SynOpen Pub Date : 2023-05-08 Swapan Kumar Biswas, Sipak Joyasawal
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Synthesis of Calix[4]arene Appended Lactosylated G1 and Galactosylated G2 Generation Glycodendrimers using a ‘CuAAC’ Click Approach SynOpen Pub Date : 2023-04-24 Sunil Kumar, Mangal S. Yadav, Sumit K. Singh, Sanchayita Rajkhowa, Vinod K. Tiwari
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Zinc Oxide (ZnO): an Amphoteric Metal Oxide with Dehydrogenating Activity SynOpen Pub Date : 2023-04-20 Rafael Ballesteros-Garrido, Rosa Adam