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Revisiting Staudinger and Ruzicka’s altered pyrethrolone: the cyclopentadienone dimers derived from pyrethrin I, cinerin I and jasmolin I Aust. J. Chem. (IF 1.1) Pub Date : 2024-03-08 Oliver E. Hutt, Jamie A. Freemont, Stella Kyi, Stuart W. Littler, Ross P. McGeary, Peter J. Duggan, John Tsanaktsidis, Helen F. Cole, Maurice G. Kerr, Elizabeth H. Krenske, John H. Ryan
The reactions of pyrethrin I, cinerin I and jasmolin I with sodium hydroxide in ethanol afforded an approximately 1:1 ratio of two respective cyclopentadienone dimers, isolated in good yield. A combination of one-dimensional and two-dimensional NMR spectroscopic studies allowed determination of the structure and stereochemistry of the dimers. The dimers are formed by cycloaddition reactions of the
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Status of rare-earth perovskite catalysts in environmental applications Aust. J. Chem. (IF 1.1) Pub Date : 2024-03-04 Pengyun Li, Aijun Gong, Jiandi Li, Lina Qiu, Xianghai Wang, Yue Chen, Jiayi Yin, Xinyu Huang, Yifan Chen
Rare-earth perovskite oxides have become a research hotspot in the fields of environment and energy owing to their structural tunability, excellent redox properties, high stability and high catalytic activity. Researchers have designed and developed different rare-earth perovskite catalysts for tackling environmental pollutants in recent years. This review summarizes recent research progress on rare-earth
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Simultaneous diversity-oriented synthesis of benzothiazoles and related diverse analogues by iodine-catalyzed intramolecular cyclization from identical substrates Aust. J. Chem. (IF 1.1) Pub Date : 2024-03-04 Meng Cui, Xue-Lin Wang, Mengzhou Wang, Jian-Wu Xie
A facile oxidative cyclization of β-ketothioamides for the simultaneous formation of a compound library similar to natural product benzothiazole derivatives has been developed. The oxidative cyclization of β-ketothioamides resulted in the simultaneous formation of four classes of previously unknown benzothiazole derivatives. This chemistry’s versatility adds a valuable component to the methodology
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Application of diglycolamide extractant in rare-earth extraction Aust. J. Chem. (IF 1.1) Pub Date : 2024-03-04 Yiwen Wang, Aijun Gong, Lina Qiu, Yuzhen Bai, Yang Liu, Ge Gao, Weiyu Zhao
Diglycolamide (DGA) extractant is a kind of rare-earth extractant with promising applications that has the advantages of high extraction capacity, ease of synthesis, good thermal stability and good radiation stability. It is a green extractant that contains only four elements, C, H, O and N, and produces no residue after incineration. The properties of DGAs containing branched N,N′-alkyl substituents
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Experimental and computational study of a multi-active-site Schiff base as corrosion inhibitor of mild steel in 1M HCl Aust. J. Chem. (IF 1.1) Pub Date : 2024-01-23 Xiaolong Li, Ting Long, Qian Wu, Chuan Lai, Yue Li, Junlan Li, Boyan Ren, Keqian Deng, Chaozheng Long, Shuting Zhao
In this study, the corrosion inhibition behavior of N,N′-(1,4-phenylene)bis(1,1-di(pyridin-2-yl)methanimine) (PBDPM) on mild steel in 1 M HCl at 30°C was evaluated under steady conditions. The corrosion inhibitor was synthesized by a one-step method. Electrochemical, energy dispersion spectrum (EDS) and water contact angle results revealed the adsorption behavior of the inhibitor at the metal–solution
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Recognising a beacon of teaching and learning leadership in Australian chemistry Aust. J. Chem. (IF 1.1) Pub Date : 2024-01-08 Alex C. Bissember, Reyne Pullen, Gwendolyn A. Lawrie
This Highlight article considers key contributions made by Professor Brian Yates to the Australian chemistry academic community in recognition of his seminal leadership that led to the establishment of the Chemistry Threshold Learning Outcomes (CTLOs) as national assessment standards. These CTLOs currently underpin the Royal Australian Chemical Institute (RACI) process of the professional accreditation
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Cobalt(II) catalytic oxidation of arylmethyl sulfonyl imines to arylcarbonyl analogues Aust. J. Chem. (IF 1.1) Pub Date : 2024-01-08 Zetao Ma, Peipei Ma, Hongli Wu, Haifeng Gan
A novel Co(OAc)2/N-hydroxyphthalimide (NHPI)-catalyzed oxidation of 3-arylmethyl sulfonyl imines to prepare 3-arylcarbonyl analogues has been realized. 3-Arylcarbonyl sulfonyl imines were comprehensively synthesized from benzyl substrates for the first time. The reactions proceeded in moderate to excellent yields. Mechanistic investigation suggests that 3-(hydroperoxy(phenyl)methyl)benzo[d]isothiazole
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Lanthanide coordination polymers based on an aromatic dicarboxylic acid and 1,10-phenanthroline ligands: synthesis, structure and luminescence properties Aust. J. Chem. (IF 1.1) Pub Date : 2023-12-12 Shu-Ju Wang, Yang Liu, Zhi-Qing Zhang, Qian Li, Gang Xiong, Li-Xin You, Yaguang Sun
A novel series of lanthanide coordination polymers (Ln-CPs) have been obtained based on mixed ligands, 2-[(4-carboxyphenyl)methoxy]benzoic acid (H2cob) and 1,10-phenanthroline (phen), namely {Ln[(Hcob)(cob)(phen)]n, Ln = La (1), Pr (2), Sm (3), Eu (4)}. Complexes 1–4 were characterized by single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction, infrared spectroscopy and thermogravimetric
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A novel ratiometric fluorescent sensor based on terpyridine derivatives for Zn 2+ in aqueous solution Aust. J. Chem. (IF 1.1) Pub Date : 2023-11-23 Qinghong Bai, Yangming Jiang, Enming Hu, Libin Lv, Chenghui Wang, Xin Xiao
Terpyridine and its derivatives have good binding affinity for most transition metal ions due to the arrangement of their three pyridine nitrogen atoms. In this work, a new ratiometric fluorescent probe G, which is based on a styrylpyridinium attached to a terpyridine fluorophore, was synthesized and characterized. The fluorescence spectrum of probe G shows a good response to Zn2+ by an intramolecular
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Approach to achieve controlled particle size synthesis of non-polar functionalised siloxane particles using a one-pot synthesis Aust. J. Chem. (IF 1.1) Pub Date : 2023-10-20 Rowan McDonough, Daniel Mangos, Chris Hassam, Jonathan Campbell, David A. Lewis
The homogeneous addition of functional silanes dissolved in a co-solvent such as ethanol has been shown to change particle growth mechanisms as well as control over particle size and dispersity, especially for non-polar silanes. Highly monodisperse size-controlled silica particles from 50 to over 1000 nm bearing thiol, vinyl, phenyl, propyl, cyanopropyl and chloropropyl R group functionality were synthesised
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Discovery and optimisation of conotoxin Vc1.1 and analogues with analgesic properties Aust. J. Chem. (IF 1.1) Pub Date : 2023-10-06 Majbrit Frøsig-Jørgensen, Jing Ji, Declan M. Gorman, Meng-Wei Kan, David J. Craik
A specimen of the marine cone snail Conus victoriae collected from a beach in Broome, Western Australia, by a group from The University of Melbourne led to the discovery of the α-conotoxin Vc1.1, which was found to have analgesic activity in rodents. The discovery of this venom-derived peptide led to a series of structural, mechanistic and pharmacological studies directed towards the development of
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Green synthesis of dual-spinneret electrospun polyacrylonitrile–ZnO@β-cyclodextrin–chitosan nanofibrous nanocomposite as a novel nano-biosorbent Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-27 Sohrab Hajmohammadi, Dadkhoda Ghazanfari, Enayatollah Sheikhhosseini, Nahid Rastakhiz, Hamideh Asadollahzadeh
A significant range of intriguing nanomaterials includes photocatalytic and antibacterial nanocomposites, which exhibit great efficacy in water treatment. In this work, Euphorbia hebecarpa extract was used as a novel natural reducing agent to investigate the environmentally friendly production of ZnO@β-cyclodextrin (CD) nanoparticles (NPs). In the following, polyacrylonitrile, ZnO@β-CD and chitosan
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Electronic structure study of H 3 BXH 3 (X═B, N and P) as hydrogen storage materials using calculated NMR and XPS spectra Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-27 Feng Wang, Delano P. Chong
Boron-based materials have been used for hydrogen storage applications owing to their high volumetric and gravimetric hydrogen density. The present study quantum mechanically investigates the electronic structures of three compounds: diborane (DB, B2H6), ammonia borane (AB, H3BNH3) and phosphine borane (PB, H3BPH3). The exploration is facilitated using calculated nuclear magnetic resonance (NMR) chemical
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Evidence for widespread torsion–vibration interaction in substituted toluenes Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-26 Jason R. Gascooke, Warren D. Lawrance
The torsional constant (F) is a parameter extracted from spectroscopic analyses of molecules possessing a methyl group. Its value depends primarily on the methyl structure. Widely varying F values have been reported for substituted toluenes in their ground electronic state, first excited singlet electronic state or the ground electronic state of the cation. Conventionally, this variability is assumed
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A computational search of the ideal metal fragment for monohapto coordination of dihydrogen Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-21 Lucía Morán-González, Feliu Maseras
Sigma complexes containing η2-H2 ligands, with both hydrogen atoms interacting with the metal center and with each other, are well known nowadays. The possibility of η1-H2 coordination, with only one hydrogen atom interacting with the metal center, remains an intriguing, but unreported, possibility. In this study, we used the hidden descriptors (HD) strategy previously developed in our group to investigate
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Novel design strategies of three-dimensional MXene structures and their applications in metal-ion hybrid capacitors Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-20 Lingfang Li, Bin Zeng, Chuang Xiang, Wen Liu
MXene is a novel two-dimensional material that exhibits excellent competitive performance in energy storage and conversion applications due to its high electrical conductivity, good dispersibility, and abundant surface functional groups. However, the van der Waals interactions between MXene nanosheets tend to lead to stacking, which limits the number of active sites and ion dynamics. Constructing MXene
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Counterpoise correction from a practical perspective: is the result worth the cost? Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-13 Bun Chan, Junming Ho
In the present study, we have examined the utility of counterpoise (CP) corrections, the zero-cost geometric counterpoise (gCP) correction, and the double-ζ vDZP basis set, in representative examples of computational chemistry investigations. The tests include reaction energies and barriers in mechanisms of catalysis, and binding of substrates with enzyme active sites. Drawbacks of the CP approach
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‘Transformative’: the threshold learning outcomes for science Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-11 Madeleine Schultz, Daniel C. Southam, Mark Buntine, Kay Colthorpe, Susan Howitt, Elizabeth Johnson, Susan Jones, Jo-Anne Kelder, Sally Kift, Wendy A. Loughlin, Glennys A. O’Brien, Simon Pyke, John Rice, Susan Rowland, Robyn Yucel
The Science Threshold Learning Outcomes (TLOs) are a consensus set of academic standards for Australian university Science education. They were developed by Prof. Brian Yates and Prof. Sue Jones, supported by Dr Jo-Anne Kelder, during 2010–2011. The co-authors of this paper are key figures in Australian Science education, and in this manuscript, we have used a reflective semi-structured interview approach
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History and fundamentals of molecular photochromism Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-06 David Jago, Emma E. Gaschk, George A. Koutsantonis
Photochromic molecules reversibly change their colour upon exposure to light. The increasing need for smart materials in the real world, coupled with progress in synthetic chemistry, fast spectroscopic techniques, and theoretical power in research laboratories, have seen research in organic photochromism accelerate over the past few decades. In this Primer Review, the topic of organic photochromism
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Correlating vapour uptake with the luminescence quenching of poly(dendrimer)s for the detection of nitro group-containing explosives Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-06 Kinitra L. Hutchinson, Beta Z. Poliquit, Andrew J. Clulow, Paul L. Burn, Ian R. Gentle, Paul E. Shaw
Thin films of two poly(dendrimer)s were studied for the detection of trace quantities of nitro-based taggants and explosives. The poly(dendrimer) structures consist of side chain-conjugated triphenylamine-based dendritic chromophores attached to a non-conjugated polymer backbone. The poly(dendrimer)s differ in terms of the conjugation length, steric bulk and surface groups of the chromophores and we
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The mechanism of cleavage of Evans chiral auxiliaries by LiOOH: origins of the different regioselectivities obtained with LiOH, LiOOH, LiOBn and LiSBn Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-06 Ka Ho Chow, Ronald J. Quinn, Ian D. Jenkins, Elizabeth H. Krenske
Oxazolidinones are widely used as chiral auxiliaries in asymmetric synthesis. The chiral auxiliary can be selectively removed using LiOOH, LiOBn or LiSBn, but not LiOH, which instead favours endocyclic cleavage with opening of the oxazolidinone ring. Although Evans originally suggested that the regioselectivity of HO−-mediated hydrolysis may be governed by the relative rates of formation of the two
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Effects of amphoteric surfactants on the dispersibility of TiO 2 nanoparticles and experimental study of enhanced oil recovery Aust. J. Chem. (IF 1.1) Pub Date : 2023-09-01 Zhangkun Ren, Lipei Fu, Xinxin Qiu, Wenzheng Chen, Wenzhe Si, Qianli Ma, Minglu Shao, Lifeng Chen, Menglin Wang, Kaili Liao
As a new type of flooding technology, the application of nano-surfactant fluids in the petroleum industry has received much attention in recent years. Stability of the nanofluids, which requires the nanoparticles to remain dispersed in the base fluid during flowing in porous media, is vital for enhanced oil recovery (EOR). In this paper, the feasibility of using amphoteric surfactants to promote the
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Flow-based assembly of nucleic acid-loaded polymer nanoparticles Aust. J. Chem. (IF 1.1) Pub Date : 2023-08-29 Zeyan Xu, Joshua McCarrol, Martina H. Stenzel
Since the development of messenger RNA (mRNA)-based SARS-CoV-2 (COVID-19) vaccines, there is increased public awareness of the importance of nanoparticles, in this case lipid nanoparticles, to ensure safe delivery of an active compound. To ensure the formation of high-quality nanoparticles with reproducible results, these lipid nanoparticles are assembled with the nucleic acid drug using flow-based
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Development of a 3-D-printable device for continuous measuring of heavy metal ion concentrations Aust. J. Chem. (IF 1.1) Pub Date : 2023-08-29 Charl de Villiers, Magdalena Wajrak, Alex Lubansky
Three-dimensional (3-D) printing offers the potential to create a range of tailored devices within many different industrial facilities. In this article, devices were designed and fabricated using 3-D printing to house electrodes for the testing of heavy metal concentration in hazardous fluids, particularly for biological samples such as urine or blood. The devices, connected to a syringe pump, were
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The supramolecular chemistry of protein cages and viruses Aust. J. Chem. (IF 1.1) Pub Date : 2023-08-22 Yu Heng Lau
There are many examples of protein cages in nature, from the outer capsid shells of viruses that protect their genetic material, to simple organelle-like structures in bacteria that house enzymes within their interior. This Account serves to introduce the world of protein cages to a chemical audience, and highlight the many similarities to concepts from supramolecular chemistry, revealing how a knowledge
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The preparation of rod-like porous α-Fe 2 O 3 with large interplanar spacing for symmetric supercapacitors Aust. J. Chem. (IF 1.1) Pub Date : 2023-08-22 Fan-Ming Yang, Xi-Da Li
Rod-like porous α-Fe2O3 was synthesized by static hydrothermal treatment at 160°C and used as a symmetric supercapacitor. The phase information, structure, morphology, valence state and composition of the prepared sample were characterized using X-ray diffraction, infrared spectroscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy
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Synthesis of naphtho- and pyrazolo-fused systems by an intramolecular Friedel–Crafts approach Aust. J. Chem. (IF 1.1) Pub Date : 2023-08-15 Hassan A. K. Abd El-Aal
Efficient access to the tetracyclic pyrazolo-fused carbo- and N-heterocyclic systems: naphtho[2′,1′:3,4]cyclohepta[2,1-c]pyrazolones, naphtho[2′,1′:5,4]azepino[6,7-c]pyrazolones, naphtho[2′,1′:5,4]azocino[6,7-c]pyrazolones and naphtho[2′,1′:6,5]azonino[7,8-c]pyrazolones is described involving intramolecular Friedel–Crafts cycliacylations of synthesized pyrazole-based carboxylic acid or ester derivatives
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An autoantigen profile from Jurkat T-Lymphoblasts provides a molecular guide for investigating autoimmune sequelae of COVID-19 Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-20 Julia Y. Wang, Wei Zhang, Michael W. Roehrl, Victor B. Roehrl, Michael H. Roehrl
In order to understand autoimmune phenomena contributing to the pathophysiology of COVID-19 and post-COVID syndrome, we have been profiling autoantigens (autoAgs) from various cell types. Although cells share numerous autoAgs, each cell type gives rise to unique COVID-altered autoAg candidates, which may explain the wide range of symptoms experienced by patients with autoimmune sequelae of SARS-CoV-2
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An autoantigen-ome from HS-Sultan B-Lymphoblasts offers a molecular map for investigating autoimmune sequelae of COVID-19 Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-19 Julia Y. Wang, Wei Zhang, Victor B. Roehrl, Michael W. Roehrl, Michael H. Roehrl
To understand how COVID-19 may induce autoimmune diseases, we have been compiling an atlas of COVID autoantigens (autoAgs). Using dermatan sulfate (DS) affinity enrichment of autoantigenic proteins extracted from HS-Sultan lymphoblasts, we identified 362 DS-affinity proteins, of which at least 201 (56%) are confirmed autoAgs. Comparison with available multi-omic COVID data shows that 315 (87%) of the
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Multilayer films of graphene oxide and polymeric microgels: reusable adsorbents Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-19 Shihan Xu, Dehuai Li, Yu Zhu, Jiaxiang Guo, Yuqin Ai, Qingyun Chu, Xinyu Yun, Xiaozhou Li, Lin Wang
Graphene oxide (GO) has arisen as an effective adsorbent for water treatment owing to its high removal efficiency for water pollutants. However, separating GO adsorbents from the pollutant solution is difficult after adsorption. The GO adsorbents are unsuitable for various dyes, and can only remove cationic dyes from an aqueous solution. To address these issues, this study utilized a simple and cost-effective
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Perspectives and opinions from scientific leaders on the evolution of data-independent acquisition for quantitative proteomics and novel biological applications Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-19 Christie L. Hunter, Joanna Bons, Birgit Schilling
The methodology of data-independent acquisition (DIA) within mass spectrometry (MS) was developed into a method of choice for quantitative proteomics, to capture the depth and dynamics of biological systems, and to perform large-scale protein quantification. DIA provides deep quantitative proteome coverage with high sensitivity, high quantitative accuracy, and excellent acquisition-to-acquisition reproducibility
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Polyadenine complexed to polyglutamine suggests the peptide backbone has a cis conformation Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-18 Anthony B. Bransgrove, Louise Amelia Anderson
The polyadenine (poly(A)) tail of mRNA is a homopolymer and as such is a potential H-bonding partner for other cellular homopolymers. The secondary structure of proteins and peptides employs the polar groups of the homopolymer backbone to bind with themselves or other polymers to respectively form an alpha helix or a beta sheet. These same backbone polar groups appear to be suitably positioned to bind
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Exploring colorimetric detection of perfluorooctane sulfonate using micelle solubilised porphyrin † Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-14 Chloe M. Taylor, Michael C. Breadmore, Nathan L. Kilah
The harmful pollutant perfluorooctane sulfonate (PFOS) is difficult to detect without extensive laboratory equipment used by trained personnel. Herein, we report the use of a micelle-encapsulated porphyrin host molecule as a rapid colorimetric indicator for PFOS and its anionic salts. A range of common commercially available surfactants were tested and optimised to encapsulate the hydrophobic highly
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The extracellular chaperone clusterin prevents primary and secondary nucleation of an amyloidogenic variant of β2-microglobulin Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-11 Manjeet Kumar, Cristina Cantarutti, David C. Thorn, Vittorio Bellotti, Gennaro Esposito, Mark R. Wilson, Heath Ecroyd, John A. Carver
Amyloid fibril formation by the extracellular protein β2-microglobulin (β2m) and its subsequent accumulation in periarticular tissues have been linked to dialysis-related amyloidosis. A natural variant of human β2m responsible for aggressive systemic amyloidosis contains an aspartate to asparagine mutation at residue 76 (i.e. D76N β2m), which readily forms amyloid fibrils in vitro under physiological
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Chemistry, biochemistry and clinical relevance of the glutamine metabolite α-ketoglutaramate/2-hydroxy-5-oxoproline Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-11 Travis T. Denton, Arthur J. L. Cooper
In the glutaminase II pathway (which we now refer to as the glutamine transaminase-ω-amidase (GTωA) pathway), l-glutamine is transaminated to α-ketoglutaramate (KGM), which, in turn, is hydrolyzed to α-ketoglutarate and ammonia by an enzyme known as ω-amidase. Despite the fact that the GTωA pathway was discovered more than 70 years ago, and is widespread in nature, the pathway has received limited
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Development of colorimetric probe for the selective detection of Hg II Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-07 Koushik Das, Mrityunjay Pandey, Shampa Chakraborty, Saumik Sen, Sandipan Halder
A selective sensing technique for HgII ions has been developed utilizing an amino acid based probe. The design, synthesis and efficacy of the chemosensor have been described. The probe (SALTYR) was successfully synthesized from a naturally occurring amino acid after sequential functional group modifications. Recognition studies were performed against a wide variety of metal cations and anions including
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Overview of the synthetic approaches to lysergic acid as a precursor to the psychedelic LSD Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-07 Michael J. Nutt, Nick Woolf, Scott G. Stewart
In this short primer we will discuss the total synthesis of lysergic acid, an important precursor to both lysergic acid diethylamide (LSD) and its derivatives. Lysergic acid is also noted as a precursor for many drugs targeting the serotonin receptor family of GPCRs, including multiple known hallucinogens. More recently, reinvigorated interest in the therapeutic potential of psychedelics from academic
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Hippo signaling in cancer: regulatory mechanisms and therapeutic strategies Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-07 Zhao Huang, Yunhan Tan, Wei Zhang, Xiangdong Tang, Edouard C. Nice, Canhua Huang
As an evolutionarily conserved pathway, Hippo signaling not only plays a key role in embryonic development, but also regulates the initiation and progression of cancer. The upstream factors regulating the Hippo pathway are complex, including cell–cell contact, cell–extracellular matrix contact, membrane receptor–ligand binding, and cytoskeletal tension. In response to these mechanical or soluble cues
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Evaluation of the 5-ethynyl-1,3,3-trimethyl-3H-indole ligand for molecular materials applications Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-06 David Jago, David C. Milan, Alexandre N. Sobolev, Simon J. Higgins, Andrea Vezzoli, Richard J. Nichols, George A. Koutsantonis
The modification of conjugated organic compounds with organometallic moieties allows the modulation of the electronic and optoelectronic properties of such compounds and lends them to a variety of material applications. The organometallic complexes [M(Cp′)(L)n] (M = Ru or Fe; Cp′ = cyclopentadiene (Cp) or pentamethylcyclopentadiene (Cp*); (L)n = (PPh3)2 or 1,2-bi(diphenylphosphino)ethane (dppe)) and
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PhotoCORMs based on zinc(ii)-flavonol derivatives with superior biological properties for use in living organisms Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-06 Le Sun, Siying An, Dong Wei, Ronglan Zhang, Jianshe Zhao
CO is an important gas signal molecule and plays an indispensable role in the maintenance of cell homeostasis. Herein, photoinduced CO-releasing molecules (photoCORMs), that combine the effects of zinc(ii) and different ligands including flavonol derivatives and tripod pyridyl compounds, are reported. The photoCORMs can release about one equivalent of CO, and the solid samples are stabile for more
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DNA-binding, multivalent interactions and phase separation in transcriptional activation Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-05 Ngaio C. Smith, Jacqueline M. Matthews
Transcription is an essential process in biology whereby gene-specific transcription factors target sites on DNA to recruit the basal transcription machinery that will produce messenger RNA (mRNA). It is a highly regulated multi-step process that involves many proteins and protein complexes. Transcription factors, the proteins that mark genes for activation, and other transcriptional regulators are
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Introduction to the chemistry and pharmacology of psychedelic drugs Aust. J. Chem. (IF 1.1) Pub Date : 2023-07-05 Scott R. Walker, Glenn A. Pullella, Matthew J. Piggott, Peter J. Duggan
The science of psychedelics is an intriguing, multi-disciplinary field that has recently been the subject of heightened public interest. This has mainly resulted from publicity associated with a number of high-profile investigations into psychedelic-assisted therapy for a range of difficult-to-treat mental health conditions. With many psychedelic substances known, including natural, semi-synthetic
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Gutenberg, chemistry and the advancement of knowledge Aust. J. Chem. (IF 1.1) Pub Date : 2023-06-30 Chris Browne
This article is a brief review of the history of printing, centred around the life and inventions of Johannes Gutenberg, who is widely regarded as the father of printing. Starting with what we know of the earliest developments in printing in China, the article will present the little knowledge we have about Gutenberg’s life and a summary of his contribution to the invention and development of the printing
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‘Renovation of old drugs’ – can peptide drug conjugates lead the post-ADC era? Aust. J. Chem. (IF 1.1) Pub Date : 2023-06-30 Chaowei Hao, Peng Chen, Hui Zhang, Sarra Setrerrahmane, Hanmei Xu
Peptide–drug conjugates (PDCs) are an emerging targeted therapeutic drug following on from the relative success of antibody–drug conjugates (ADCs). In this class, peptides are used to target payload molecules at the disease sites, thereby reducing toxicity and improving the physicochemical properties of the payload. A PDC is composed of three parts: peptide, linker and toxin molecule, and in this structure
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A holistic approach towards a generalizable machine learning predictor of cell penetrating peptides Aust. J. Chem. (IF 1.1) Pub Date : 2023-06-21 Bahaa Ismail, Sarah Jones, John Howl
The development of machine learning (ML) predictors does not necessarily require the employment of expansive classifiers and complex feature encoding schemes to achieve the highest accuracy scores. It rather requires data pre-processing, feature optimization, and robust evaluation to ensure consistent results and generalizability. Herein, we describe a multi-stage process to develop a reliable ML predictor
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Differential membrane binding of α/β-peptide foldamers: implications for cellular delivery and mitochondrial targeting Aust. J. Chem. (IF 1.1) Pub Date : 2023-06-14 Tzong-Hsien Lee, James W. Checco, Tess Malcolm, Chelcie H. Eller, Ronald T. Raines, Samuel H. Gellman, Erinna F. Lee, W. Douglas Fairlie, Marie-Isabel Aguilar
The intrinsic pathway of apoptosis is regulated by the Bcl-2 family of proteins. Inhibition of the anti-apoptotic members represents a strategy to induce apoptotic cell death in cancer cells. We have measured the membrane binding properties of a series of peptides, including modified α/β-peptides, designed to exhibit enhanced membrane permeability to allow cell entry and improved access for engagement
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Fast protodeboronation of arylboronic acids and esters with AlCl 3 at room temperature Aust. J. Chem. (IF 1.1) Pub Date : 2023-06-14 Zhijun Yuan, Yunshi Liang, Yiting He, Huiying Deng, Haiting Wu, Bohong Lin, Jing Zhang
AlCl3-mediated protodeboronation of arylboronic acids and esters is reported herein. This method features mild reaction conditions, high reaction yields, as well as short reaction times. Mechanistic studies based on 11B NMR spectroscopy suggest that it might proceed through initial boron activation by coordination of AlCl3 to the oxygen atom of arylboronic acid or ester groups.
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Synthesis of hydrogels incorporating core–shell structured Fe 3 O 4 @ZIF-8 as bio-nanocomposite carriers for drug delivery Aust. J. Chem. (IF 1.1) Pub Date : 2023-06-15 Pagasukon Mekrattanachai, Naruemon Setthaya, Chakkresit Chindawong, Bunlawee Yotnoi, Wei Guo Song, Chawan Manaspon
Due to its high porosity and excellent pH-sensitive breakdown, the zeolitic imidazolate framework-8 (ZIF-8) has been investigated as a drug delivery vehicle. To increase the magnetic property of ZIF-8 nanoparticles, Fe3O4 nanoparticles (Fe3O4 NPs) were encapsulated to form a core–shell structure (Fe3O4@ZIF-8). The core–shell particles were then incorporated into a hydrogel to increase biocompatibility
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Palladium-mediated CO 2 extrusion followed by insertion of ketenes: translating mechanistic studies to develop a one-pot method for the synthesis of ketones Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-31 Yang Yang, Allan J. Canty, Richard A. J. O’Hair
Multistage mass spectrometry (MSn) experiments were used to explore extrusion–insertion (ExIn) reactions of the palladium complex [(phen)Pd(O2CPh)]+ (phen, 1,10-phenanthroline). Under collision-induced dissociation (CID) conditions, the organopalladium cation [(phen)Pd(Ph)]+ was formed via decarboxylation and was found to react with phenylmethylketene to yield the enolate [(phen)Pd(CPhMeC(O)Ph)]+ via
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Phenotyping CHST3 skeletal dysplasia from freezer-induced urine sediments Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-31 Edward S. X. Moh, Andreas Zankl, Nicolle H. Packer
Skeletal dysplasias are a group of rare genetic disorders that affect growth and development of the skeleton, leading to physical deformities and other medical problems. High-throughput genome sequencing technologies have made it easier to genotype the disorder, but do not always reflect the phenotypic outcome. CHST3-related skeletal dysplasia is caused by the reduced function of the carbohydrate sulfotransferase
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Directed chemical dimerisation enhances the antibacterial activity of the antimicrobial peptide MSI-78(4–20) Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-31 Rong Li, Thomas N.G. Handley, Wenyi Li, Neil M. O’Brien-Simpson, Mohammed Akhter Hossain, John D. Wade
Antimicrobial resistance (AMR) is on the rise, leading to 700 000 deaths worldwide in 2020. Antimicrobial peptides (AMPs) are antibiotic agents that are active against multi-drug resistant pathogens and also have a reduced risk of AMR development. Previous studies have shown that dimerisation of the proline-rich antibacterial peptide (PrAMP) Chex1–Arg20 can enhance its antimicrobial activity while
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The C-terminal pentapeptide acein analogue (JMV3315) stimulates dopamine release in the brain Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-31 Charlène Lucas-Valmalle, Gilles Subra, Pascal Verdié, Marie-Lou Kemel, Valérie Daugé, Karine Puget, Jean Martinez
We have previously reported the synthesis and biological activity of a newly identified peptide of sequence H–Pro–Pro–Thr–Thr–Thr–Lys–Phe–Ala–Ala–OH called acein that is able to stimulate dopamine release in the brain of rodents in vivo and ex vivo by interacting with angiotensin converting enzyme (ACE). In the present piece of work, we studied the structure–activity relationships of acein using displacement
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Highly accurate CCSD(T) homolytic Al–H bond dissociation enthalpies – chemical insights and performance of density functional theory Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-24 Robert J. O’Reilly, Amir Karton
We obtain gas-phase homolytic Al–H bond dissociation enthalpies (BDEs) at the CCSD(T)/CBS level for a set of neutral aluminium hydrides (which we refer to as the AlHBDE dataset). The Al–H BDEs in this dataset differ by as much as 79.2 kJ mol−1, with (H2B)2Al–H having the lowest BDE (288.1 kJ mol−1) and (H2N)2Al–H having the largest (367.3 kJ mol−1). These results show that substitution with at least
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Identification of NQO1 as a target of herbal drug agrimol B in hepatocellular carcinoma Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-24 Dingyue Zhang, Lixia Dong, Wenyong Yang, Kui Wang
Agrimol B is a small molecule isolated from traditional Chinese herbal medicine with a potential anti-cancer effect. However, the molecular target of agrimol B remains unclear. In this report, we found that agrimol B inhibits the growth of hepatocellular carcinoma (HCC) cells. A combination of network pharmacology strategy, bioinformatics analysis, molecular docking and target validation experiments
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A review of psilocybin: chemistry, clinical uses and future research directions Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-17 Eliza Milliken, Peter Galettis, Jenny Martin
Classic psychedelics such as psilocybin, ketamine and lysergic acid diethylamide (LSD) are 5HT2A serotonin receptor agonists that produce individualised subjective affects. Today, public interest in psychedelic medicine has reached a fervour but the evidence for clinical benefit still lags. Psilocybin and psilocin are tryptophan based alkaloids found worldwide in mushrooms of the genera Psilocybe,
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Nonlinear optics: from theory to applications, with a focus on the use of two-photon absorption in biology Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-12 Mélanie Dréano, Olivier Mongin, Frédéric Paul, Mark G. Humphrey
The study of nonlinear optics in the 1960s attracted considerable attention from a theoretical standpoint, engendering many proposals for practical use of these new photonic effects. Among these suggestions, the development of efficient two-photon absorption (2PA) has attracted sustained interest due to its demonstrated (or potential) use in a broad range of applications that include optical data storage
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Advances in high abundance protein molecular imprinting techniques in human serum Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-08 Zhipeng Liu, Aijun Gong, Lina Qiu, Yang Liu, Shujia Zheng, Wenyan Qin, RongRong Fan
The detection of protein biomarkers is crucial for early disease diagnosis. However, these biomarkers are present at low levels in serum, and the detection signal is easily interfered with by high levels of proteins. These factors pose major challenges for direct biomarker detection by existing technologies; thus, sample pre-treatments are performed as the best solution. Molecularly imprinted polymers
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On the development of proteomics: a brief history † Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-04 Ralph A. Bradshaw
Although one can trace the roots of proteomics well back into the 20th century, it is basically a discipline of the new millennium. At its outset, it was defined primarily by the technology available to analyze complex mixtures (basically 2D-gel electrophoresis, hybridizations/arrays and mass spectrometry) and what mainly set it aside from protein chemistry, that had flourished since the end of the
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Photocycloadditions of benzene derivatives and their systematic application to organic synthesis Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-04 Arthur Desvals, Norbert Hoffmann
Photocycloadditions of benzene derivatives with alkenes play an important role as key steps in organic synthesis. Intramolecular reactions have been most frequently studied in this context. Often, meta or [2 + 3] photocycloadditions take place in competition with ortho or [2 + 2] additions. The influence of the substitution pattern and the spin multiplicity of the excited state on the outcome of these
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Alkaloids from the entheogenic plant Peganum harmala Aust. J. Chem. (IF 1.1) Pub Date : 2023-05-04 Daniel G. Anstis, Jessica Liyu, Emma K. Davison, Jonathan Sperry
Entheogenic natural products (e.g., psylocybin and dimethyltryptamine) are emerging as effective therapeutics to treat debilitating mood disorders that are unresponsive to conventional treatment. The detailed evaluation of psychotropic plants will conceivably lead to the discovery of structurally distinct entheogens that may offer improved or complementary medicinal properties to the classic entheogens