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Synthetic strategies and anticancer evaluation for the novel 3-(6-heteroaryltriazolo[3,4-b][1,3,4]thiadiazol-3-yl)chromeno [2,3-b]pyridines Synth. Commun. (IF 2.1) Pub Date : 2024-03-18 Najla A. Alshaye, Magdy A. Ibrahim
The novel chromonyltriazolo[3,4-b][1,3,4]thiadiazole derivative 5 was efficiently synthesized and utilized as key intermediate for construction of a diversity of heterocyclic rings; through reactio...
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The Lacunae identified in processing, analyzing and finding means of catalyst free Oxone mediated through C-3 oxidation of N-alkyl quinoxalin-2(1h)-one Synth. Commun. (IF 2.1) Pub Date : 2024-03-18 Vikas S. Patil, Gayathri Chunduri, Balaram Kiran Avasarala, Gangaiah L, Pasham Yoganand, Kola Srinivas, Murali Koparala, Nagaraju Devunuri
A catalyst free oxone mediated synthesizing N-alkyl 1, 4-dihydroquinoxaline-2,3-dione has been developed by oxidation of the N-alkyl quinoxalin-2(1H)-one. The developed method is a novel, safest, c...
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Novel pyrano[2,3-c]pyrazolopyrimidines as promising anticancer agents: Design, synthesis, and cell cycle arrest of HepG2 cells at S phase Synth. Commun. (IF 2.1) Pub Date : 2024-03-10 David S. A. Haneen, Mohamed H. Hekal, Wael S. I. Abou-Elmagd, Wael M. El-Sayed
The poor selectivity, significant toxicity, high cost, and emergence of resistance of conventional chemotherapies are driving motive for the ongoing search for novel anticancer agents. New pyrano[2...
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Sustainable synthesis of imidazoles using a catalyst-free approach and ethyl lactate as a bio-based green solvent in the Debus-Japp-Radziszewski reaction Synth. Commun. (IF 2.1) Pub Date : 2024-03-08 Flavia Martins da Silva, Joel Jones Junior, July A. Hernández Muñoz, Priscila Nogueira de Azevedo
A highly substituted family of imidazoles is effectively obtained through the Debus-Japp-Radziszewski reaction. In this process, benzil, ammonium acetate, and various benzaldehydes react in a parti...
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Asymmetric Diels–Alder reaction of chalcone and isoprene mediated by titanium-based complexes Synth. Commun. (IF 2.1) Pub Date : 2024-03-07 Chun Keng Thy, Yean Kee Lee, Iskandar Abdullah, Noorsaadah Abd Rahman, Chin Fei Chee
The asymmetric Diels–Alder reaction of chalcone and isoprene has been accomplished by use of chiral titanium complexes. Notably, an enantiomeric excess as high as 61% and a regioselectivity of 95% ...
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Synthesis of 1H-benzimidazoles via the condensation of o-phenylenediamines with DMF promoted by organic acid under microwave irradiation Synth. Commun. (IF 2.1) Pub Date : 2024-03-06 Wenjuan Li, Xiao Li, Hailong Hong, Ruijun Xie, Ning Zhu
An effective, green and eco-friendly method was developed to synthesize 1H-benzimidazole under microwave irradiation. The reactions of substituted o-phenylenediamine with DMF were efficiently promo...
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Design, synthesis and antibacterial assessment of novel 4H-chromene analogues Synth. Commun. (IF 2.1) Pub Date : 2024-02-29 Safaa S. M. Shaban, David S. A. Haneen, Mohsen M. Abou-El-Regal, Souad A. El-Metwally
The significant medicinal and pharmacological facts about chromenes (benzopyran) nucleus prompted us to focus on constructing unique chromenes with biological value. New chromene derivatives 2–15 w...
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Design, synthesis, and molecular docking study of N-(arylsulfonyl)-l-proline-piperazine hybrids tethered with pyrazole/benzofuran moiety as antimicrobial agents Synth. Commun. (IF 2.1) Pub Date : 2024-02-28 Jaydeo T. Kilbile, Siddique Akber Ansari, Suchita S. Gadekar, Vagolu S. Krishna, Manoj G. Damale, Bharat B. Kashid, Jaiprakash N. Sangshetti, Suryakant B. Sapkal
In search of novel antimicrobial agents, new series of N-(arylsulfonyl)-l-proline-derived hybrids tethered with pharmacologically attractive cores as 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine...
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An efficient four-component protocol for synthesis of poly-substituted pyridines with SiO2 as a robust recyclable catalyst Synth. Commun. (IF 2.1) Pub Date : 2024-02-28 V. N. Chandra Sekhar, Gorle Simhachalam, L. Vaikunta Rao, A. V. Dhanunjaya Rao, Madhavaram Shankar, Akula Raghunadh
A four-component protocol for the development of poly-substituted pyridines derivatives by using SiO2 as a recycle catalyst. The protocol offers good to excellent yields (85%-95%) under milder cond...
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Sulfonamide tethered 1,4-disubstituted 1,2,3-triazoles: Synthesis and antibacterial evaluation Synth. Commun. (IF 2.1) Pub Date : 2024-02-27 Jyoti Yadav, C. P. Kaushik
A series of twenty one sulfonamide tethered 1,4-disubstituted 1,2,3-triazoles was synthesized in good yields through a facile expeditious click synthetic protocol involving Cu(I) mediated cyclizati...
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Asymmetric synthesis, characterization of chiral trans and cis-3-chloro/oxo/thio-4-styryl-β-lactams using (R)-(+)-1-phenylethylamine and their efficient column chromatographic separation Synth. Commun. (IF 2.1) Pub Date : 2024-02-27 Anu Kumari, Ankita Garg, Subash Chandra Sahoo, Aman Bhalla
Diverse chiral trans and cis-3-chloro/oxo/thio-4-styryl-β-lactams were efficiently synthesized using chiral 3′-phenylallylidene-[(R)-1′-phenylethyl] amine and substituted ethanoic acids. Moore kete...
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A facile, regio and diastereoselective synthesis of functionalized azetidin-2-ones: Cu(I) mediated Kinugasa reaction of functionalized nitrones with acetylenic alcohols Synth. Commun. (IF 2.1) Pub Date : 2024-02-26 Priyanka Sharma, Dinesh Mahajan, Vipan Kumar, Rupesh Kumar, Gaurav Bhargava
The manuscript presents an efficient method for the synthesis of various cis-azetidin-2-ones with high regio- and diastereoselectivity. This approach utilizes Kinugasa reaction involving diverse fu...
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Review of synthesis process of benzimidazole-heterocycle hybrid compounds Synth. Commun. (IF 2.1) Pub Date : 2024-02-16 Abouelhaoul El Alami, Hamid Sdassi, Said Bouzikri
Over the last few years, benzimidazole-heterocycle hybrid compounds have received considerable attention due to the wide spectrum of their biological property and many important chemical and pharma...
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Photosensitizer-free, visible light-mediated heterogeneous gold-catalyzed cross-coupling of aryldiazonium salts with allyltrimethylsilane Synth. Commun. (IF 2.1) Pub Date : 2024-02-11 Jiajia Li, Boling Song, Mingzhong Cai
An efficient visible light-mediated and heterogeneous gold-catalyzed cross-coupling of aryldiazonium tetrafluoroborates and allyltrimethylsilane has been developed. The photosensitizer-free cross-c...
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An efficient synthesis of 4,5-disubstituted 1,2,3-triazoles by three-component reaction between sodium azide, ethyl cyanoacetate or malonitrile and arylglyoxals Synth. Commun. (IF 2.1) Pub Date : 2024-02-11 Akram Ranjbar Derranji, Mohammad Anary-Abbasinejad
Three-component reaction between sodium azide, ethyl cyanoacetate or malonitrile and arylglyoxals afforded 4,5-disubstituted 1,2,3-triazole derivatives in high yields. All reactions were conducted ...
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A simple, facile and greener route to thiazolo[3,2-c]pyrimidinones in semi-aqueous medium and their antibacterial properties Synth. Commun. (IF 2.1) Pub Date : 2024-02-10 Kübra Uysal, Muhammet Yıldırım, Hamza Karakuş, Arzu Yıldırım
By using easily accessible heterocyclic enamines, acetaldehyde (or formaldehyde) and primary amines as suitable precursors, a water-assisted three-component synthesis of new 3-oxothiazolo[3,2-c]pyr...
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P4O10/TfOH-mediated metal-free synthesis of 4-hydroxycoumarins and a one-pot strategy to build their hybrids Synth. Commun. (IF 2.1) Pub Date : 2024-02-01 G. D. Kotkar, S. G. Tilve
4-Hydroxycoumarins are among the most versatile heterocyclic scaffolds, and they are extensively used in the synthesis of a wide range of chemical molecules. Because of their biological and pharmac...
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Novel organic–inorganic hybrid dimethyltin(IV) complexes of heterocyclic carboxylic acid and N-phthaloyl amino acids: Design, synthesis, spectroscopic characterization, DFT calculations and their anti-oxidant potential Synth. Commun. (IF 2.1) Pub Date : 2024-02-01 Ankur M. Kumar, Suchitra Budania, Asha Jain
Four new organic–inorganic hybrid dimethyltin(IV) complexes (1–4) having general formula Me2SnAL which were generated by the reaction of dimethyltin(IV) dichloride with sodium salts of indole-3-ace...
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Synthesis of allomaltol containing terarylenes with imidazole N-oxides bridge fragment Synth. Commun. (IF 2.1) Pub Date : 2024-02-01 Constantine V. Milyutin, Andrey N. Komogortsev, Boris V. Lichitsky, Valeriya G. Melekhina
Method for the synthesis of previously unknown imidazole N-oxides bearing allomaltol unit has been elaborated. The presented approach is based on multicomponent condensation of corresponding oximes...
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Friedländer reactions for novel annulated pyridotriazolothiazolopyridines: Synthetic approaches and antimicrobial evaluation Synth. Commun. (IF 2.1) Pub Date : 2024-02-01 Youssef A Alnamer, Magdy A Ibrahim
o-Aminoaldehyde 1 was employed as starting precursor for construction of some linear heterocyclic compounds. o-Aminoaldehyde 1 was permitted to undergo Friedländer reaction with some acyclic and cy...
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Asymmetric aza-Henry reaction of BOC-protected imines with zinc-FAM catalyst Synth. Commun. (IF 2.1) Pub Date : 2024-02-01 Nurzhan Beksultanova, Özdemir Doğan
Derivatives of ferrocenyl-substituted aziridinyl methanol (FAM) ligands were used with zinc metal for asymmetric aza-Henry (nitro-aldol) reaction of N-Boc protected imines with nitroalkanes. At opt...
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Green synthesis of some new azolopyrimidines as antibacterial agents based on thiophene-chalcone Synth. Commun. (IF 2.1) Pub Date : 2024-02-01 Salwa Magdy Eldaly, Nadia Hanafy Metwally
Optimization of green synthesis for a novel pyrazolo[1,5-a]pyrimidines 3a-i, 7a-f, triazolo[4,3-a]pyrimidine 8 and benzo[4,5]imidazo[1,2-a]pyrimidine 9 were synthesized from the reaction of 1-(4-am...
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Correction Synth. Commun. (IF 2.1) Pub Date : 2024-01-08
Published in Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry (Vol. 54, No. 4, 2024)
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NaOH promoted hydrolysis of α-oxo ketene-N, S-acetals: Effective synthesis of β-keto amides Synth. Commun. (IF 2.1) Pub Date : 2024-01-08 Liangliang Li, Chunxu Jiang, Tingting Peng, Nuonan Zhang, Jing Ji, Haifeng Yu, Xiaobo Zhao
An effective and novel synthesis of β-keto amides had been developed by NaOH promoted hydrolysis of α-oxo ketene-N, S-acetals. It was found that the hydrolysis of α-oxo ketene-N, S-acetals in the p...
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Design, synthesis, anticancer evaluation, and molecular docking studies of 1,3,4-thiadiazole bearing 1,3,5-triazine-thiazoles Synth. Commun. (IF 2.1) Pub Date : 2024-01-08 Somaiah Nalla, Y. Pavani, Gollapudi Ravi kumar, Poodari Sumalatha, Tasqeeruddin Syed, Mannam Subbarao
A new library of 1,3,4-thiadiazole bearing 1,3,5-triazine-thiazole (9a–j) compounds have been designed, synthesized, and assessed for their in vitro anticancer applications against a panel of human...
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Synthesis and biological evaluation of amide derivatives of the quinazoline tethered (pyridyl)-1,2,4-thiadiazoles as anticancer agents Synth. Commun. (IF 2.1) Pub Date : 2024-01-08 Krishna Reddy Gankidi, S. Shivakumara, Nagendra Govindappa
A new library of amide derivatives of quinazoline-1, 2, 4-thiadiazoles (12a–j) has been synthesized and its structures were confirmed by 1H NMR, 13C NMR and mass spectral data. The in-vitro antican...
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An efficient synthesis, characterization, antimicrobial and anticancer activities of azo dyes derived from eugenol Synth. Commun. (IF 2.1) Pub Date : 2024-01-08 Santosh V. Dandge, Sumit R. Nikume, Ratnamala S. Bendre
A new series of azo dyes of the naturally occurring phenol i.e., eugenol (4-allyl-2-methoxyphenol) was produced by the conventional method. For the synthesis of azo compounds, diazonium salts were ...
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Montmorillonite K10 clay accelerated green protocol for the pseudo-five-component synthesis of substituted imidazo[1,2-a]pyridines Synth. Commun. (IF 2.1) Pub Date : 2024-01-08 Pragati Sharma, Pragya Sinha
An array of conjugated Imidazo[1,2-a]pyridines were synthesized via a one-pot, pseudo-five-component reaction incorporating aryl aldehydes, malononitrile, thiophenol or phenol, and acetophenone or ...
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Synthetic Approaches and Biological Applications of Aminopyrazolecarbonitriles Synth. Commun. (IF 2.1) Pub Date : 2024-01-08 Mohamed Abdel-Megid, Magdy A. Ibrahim, Al-Shimaa Badran, Kamelia M. El-Mahdy
We have framed a detailed account of the synthetic methods and the bioactivity and pharmacological aspects available for aminopyrazolecarbonitriles as they have substantial role as a building block...
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Oxime ligands: Organometallic synthesis and catalysis Synth. Commun. (IF 2.1) Pub Date : 2023-12-28 Suresh Iyer
Ligands are at the heart of coordination chemistry. They conjure the magic of transition metals expressed in organometallic catalysis. Phosphine or P-ligands have found vast utility in transition m...
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Design, Synthesis and Biological Evaluation of Aryl Benzimidazole-Pyridones as Cytotoxic Agents Synth. Commun. (IF 2.1) Pub Date : 2023-12-26 G. Sabita, Tasqeeruddin Syed, R. Savitha, K. Divya, Nalla Somaiah, K. Bhaskar
A new library of Aryl Benzimidazole-Pyridones (9a–j) has been synthesized, their structures were determined by 1HNMR,13CNMR and mass spectral data. Further, these compounds explored for their antic...
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Green and eco-friendly synthesis of quinolone substituted indolyl-4H-chromenes via C–C bond formation Synth. Commun. (IF 2.1) Pub Date : 2023-12-26 Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported using L-proline as a catalyst and water as a promoter solvent. The ca...
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Pyrrolizine-3-ones: Synthesis and evaluation of photophysical properties Synth. Commun. (IF 2.1) Pub Date : 2023-12-26 Dilek Isik Tasgin, Irem Bayraktar
We describe a synthetic approach for pyrrolizine-3-one derivatives and their photophysical properties. These compounds are prepared by a series of reactions employing the substituted pyrroles in on...
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Review of synthesis process of nitrobenzimidazole derivatives Synth. Commun. (IF 2.1) Pub Date : 2023-12-26 Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Nitrobenzimidazoles have become increasingly important in recent years, particularly in the design of new classes of compounds with demonstrated activity in medicinal, therapeutic and chemical fiel...
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Synthesis and characterization of four diastereomers of β-lactamase inhibitor drug intermediate Synth. Commun. (IF 2.1) Pub Date : 2023-12-26 Amit Pund, Aniruddha Varangaonkar, Vipul Rane, Vinod Ahirrao, Mohammad Rafeeq, Ravindra Yeole, Arvind Merwade
A short and efficient stereo-specific synthesis of three stereoisomers (two diastereomer and one enantiomer) of Oxalate salt of benzyl (2S,5R)-5-(benzyloxyamino)piperidine-2-carboxylate (8) has bee...
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A simple and convenient synthesis of labeled 9-hydroxy[13C6]phenanthrene as internal standard for mass spectrometry quantification of a key phenanthrene metabolite in human urines Synth. Commun. (IF 2.1) Pub Date : 2023-12-26 Jean-Yves Sancéau, Éric Gaudreau, René Maltais, Donald Poirier
A simple and convenient synthesis of 9-hydroxy[13C6]phenanthrene has been developed from one-ring labeled [13C6]phenanthrene in three steps, involving a copper-ethyl acetate catalyzed “Ullmann-type...
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Concise review on isolation, biological activity, structure elucidation, and total synthetic approaches of 16-membered C2-symmetric macrolide pyrenophorol Synth. Commun. (IF 2.1) Pub Date : 2023-12-25 Bheemreddy Anusha, Raveendra Babu Kothapalli, Miriyala Victor Prem Sagar, Bairla Surendra, Ummareddy Venkata Subba Reddy
This review article provided isolation, biological activity, structural elucidation, and summary of the comprehensive synthesis of the sixteen-membered C2-symmetric macrolide dilactone pyrenophorol...
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Microwave-assisted synthesis of indolizine derivatives: Recent developments: A review (2003-present) Synth. Commun. (IF 2.1) Pub Date : 2023-12-25 Sujit Ghosh, Kinkar Biswas
Microwave-assisted organic synthesis has emerged as the best replacement for the conventional thermal synthetic methodology in organic reactions. It is one of the effective non-conventional activat...
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Synthesis of α,β-diamino acid derivatives by acid-catalyzed Aza-Michael addition of N-phthalyldehydroalanine with different amine Synth. Commun. (IF 2.1) Pub Date : 2023-12-11 Ya-Fei Li, Lu-Lu Chen, Ya-Ru Deng, Yan-Ru Fan, Zhen-Yu An, Yu Huang
A series of α,β-diamino acid derivatives were synthesized from N-phthalyldehydroalanine with different amines by acetic acid catalytic Aza-Michael additions. This reaction achieves C–N bond formati...
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Recent advances in the synthesis of 3(5)-trifluoromethylpyrazoles Synth. Commun. (IF 2.1) Pub Date : 2023-12-11 Ranjana Aggarwal, Swati Sharma
This review mainly focused on the synthesis of 3(5)-trifluoromethylpyrazoles via condensation of trifluoromethyl-β-diketones with hydrazines. Also, a special emphasis is led on the biological poten...
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An efficient synthesis of C-6 aminated 3-bromoimidazo[1,2-b]pyridazines Synth. Commun. (IF 2.1) Pub Date : 2023-12-11 Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Treatment of 3-bromo-6-chloroimidazo[1,2-b]pyridazine with a variety of 1° or 2° alkylamines (2.0 equiv) with CsF (1.0 equiv), and BnNEt3Cl (10 mol %) in DMSO at 100 °C (24 hours) gave the correspo...
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Design, synthesis, and characterization of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole derivatives: Anticancer and molecular docking investigations Synth. Commun. (IF 2.1) Pub Date : 2023-12-11 Nilesh Raghunath Khedkar, Alex Joseph, Milind Sindkhedkar
Herein, we present a new library of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole (14a–j) as an anticancer agent designed based on in silico fragment-based drug design (FBDD). The derivatives...
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Design, synthesis and antimicrobial activity of heteroannulated chromeno[3′,2′:5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines Synth. Commun. (IF 2.1) Pub Date : 2023-12-11 F. M. Alshareef, Sami A. Al-Harbi, Esam S. Allehyani, Omeima Abdullah, Magdy A. Ibrahim
The current research is directed to construct a novel category of linear annulated chromeno[3`,2`:5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines. The chemical reactivity of the recently synthesiz...
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A simple sequential one-pot synthesis of 4-aryl thiazole-based Schiff bases Synth. Commun. (IF 2.1) Pub Date : 2023-12-11 Preethi Dhanapal, S L Manju
Thiazole based Schiff base scaffolds in recent years have become the integral part of the drug development. These scaffolds are gaining much importance due to their widespread uses as versatile bui...
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Recent insights into synthesis, biological activities, structure activity relationship and molecular interactions of thiazolidinone hybrids: A systematic review Synth. Commun. (IF 2.1) Pub Date : 2023-11-28 Sabnam Parveen, Ritchu Babbar, Vishnu Nayak Badavath, Suman Kumar Nath, Sourabh Kumar, Ravi Rawat, Sridevi Chigurupati, Rohini Karunakaran, Pranay Wal, Monica Gulati, Tapan Behl
The thiazolidinone component is a specialized frame exhibiting various biological reactions comprising analgesic, hypnotic, antiviral, anticancer, antitubercular, and many more. As the target scaff...
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Design, synthesis, and antimicrobial evaluation of new antipyrine derivatives bearing thiazolopyridazine and pyrazolothiazole scaffolds Synth. Commun. (IF 2.1) Pub Date : 2023-11-28 Zahra M. Alamshany
In the current research, a new set of antipyrine–thiazole hybrids were designed and synthesized and screened for their antimicrobial activities against Gram-positive and Gram-negative bacteria and ...
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An efficient synthesis of novel coumarinyldihydropyrimidin-2-thiones via coumarinylenones Synth. Commun. (IF 2.1) Pub Date : 2023-11-28 Abhilash Tyagi, Kuldeep Mahiya, Rajesh Kumar, Sukhdev Singh
The novel coumarinyldihydropyrimidin-2-thiones (coumarinyl-DHPM) have been synthesized by Knoevenagel condensation of 4-formylcoumarins with different β-keto esters in the presence of aluminum chlo...
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Base promoted coupling of α-ketoacids and 2-substituted aromatic amines: Green synthesis of diverse benzoxazoles, benzothiazoles, quinoxalinones and benzoxazinones and its practical application Synth. Commun. (IF 2.1) Pub Date : 2023-11-28 Sivagami Mathavan, Subburethinam Ramesh, Rajesh B. R. D. Yamajala
Synthesis of 2-aryl substituted benzoxazoles, benzothiazoles, and quinoxalinones via decarboxylative coupling of α-keto acids with 2-aminophenol, 2-aminothiophenol, and OPD (o-phenylenediamine), us...
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Design, synthesis, anticancer evaluation and molecular docking studies of 1,2,4-oxadiazole incorporated indazole-isoxazole derivatives Synth. Commun. (IF 2.1) Pub Date : 2023-11-28 Jesse Lingam, Bijaya Ketan Sahoo, Bala Divya Mallavarapu, Reddymasu Sreenivasulu
A new series of 1,2,4-oxadiazole incorporated indazole-isoxazole (12a–j) derivatives were designed, synthesized and confirmed their structures by 1HNMR, 13CNMR and mass spectral analysis. Further, ...
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An efficient, concise synthetic approach to γ-aminobutyric acid (GABA) derivatives bearing bicyclo[2.2.2]octane and bicyclo[2.2.1]heptane rings Synth. Commun. (IF 2.1) Pub Date : 2023-11-28 Wen Luo, Xinqiang Cheng, Xinyuan Zhu, Yong Li, Yongjia Liu, Wenqian Huang, Yan Li, Guilong Zhao
An efficient, concise 5-step synthetic approach to γ-aminobutyric acid (GABA) derivatives bearing bridged bicyclo[2.2.2]octane and bicyclo[2.2.1]heptane rings was developed, which consists of Diels...
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Synthesis, antibacterial activity evaluation and molecular docking studies of coumarin modified thiouracil derivatives as SecA inhibitor Synth. Commun. (IF 2.1) Pub Date : 2023-11-10 Hong Zhang, Penglei Cui, Xinming Hu, Hongya Li
A series of thiouracil derivatives containing coumarin were designed and synthesized with SecA inhibitor 1 as the lead. The in vitro antibacterial activities of the newly synthesized compounds were...
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Design, synthesis, antibacterial evaluation, and molecular docking studies of diethyl((substituted phenyl)((4-(N-(5-methyl-4,5-dihydroisoxazol-3-yl)sulfamoyl)phenyl) amino)methyl)phosphonates Synth. Commun. (IF 2.1) Pub Date : 2023-11-10 Mohan Gundluru, Santhisudha Sarva, Sumithra Poreddy, Poojitha B, Ashwini John, Selvarajan Ethiraj, Suresh Reddy Cirandur
An efficient green synthesis of diethyl((substituted phenyl)((4-(N-(5-methyl-4,5-dihydroisoxazol-3-yl)sulfamoyl)phenyl) amino)methyl)phosphonates was accomplished by the condensation of 4-amino-N-(...
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Facile synthesis of 3-(pyrazol-1-yl) succinimides from Ag2CO3 -catalyzed aza-Michael addition of pyrazoles to maleimides Synth. Commun. (IF 2.1) Pub Date : 2023-11-10 Xue Zhang, Jian Mo, Da-Shuang Luo, Xue-Min Niu, Hai-Feng Yu, Xiao-Bo Zhao
Herein, an effective and facile synthesis of 3-(pyrazol-1-yl) succinimides is first presented through silver-catalyzed aza-Michael addition of pyrazoles to maleimides. In the presence of 5 mol% of ...
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2a-Alkylnorlitebamines and (7a,8)-didehydroisohomoaporphines: Synthesis and antiacetylcholinesterase activity verified via in silico molecular docking Synth. Commun. (IF 2.1) Pub Date : 2023-11-10 Ya-En Cheng, Sheau-Ling Ho, Sheng-Fa Tsai, Ming-Che Cheng, Ching-Yi Lu, Chia-Chuan Chang, Shoei-Sheng Lee
As N-alkyl-norlitebamines have been demonstrated to possess antiacetylcholinesterase activity, this study aimed to prepare related analogs to verify their structure–activity relationship. The compo...
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A convenient synthesis of β-ketophosphine oxides via Ag-mediated oxidative phosphorylation of α-bromostyrenes Synth. Commun. (IF 2.1) Pub Date : 2023-11-10 Dae Young Kim
Ag-mediated radical phosphorylation of α-bromostyrenes with diphenylphosphine oxides is described. This approach represents a convenient method for the preparation of β-ketophosphine oxides with mo...
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Synthesis of the substituted 7H-pyrano[2,3-d]isoxazol-7-ones from allomaltol-containing oximes Synth. Commun. (IF 2.1) Pub Date : 2023-11-10 Constantine V. Milyutin, Andrey N. Komogortsev, Valeriya G. Melekhina, Boris V. Lichitsky
Convenient approach for the synthesis of previously unknown 7H-pyrano[2,3-d]isoxazol-7-one core was elaborated. The presented method is based on two stage process including preparation of diketone ...
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Recent developments of nanocatalysts for Stille coupling reaction Synth. Commun. (IF 2.1) Pub Date : 2023-11-10 Sasadhar Majhi, Shyamal K. Jash
In organic synthesis, the Stille reaction is one of the most general, effective, and selective Pd-catalyzed cross-coupling reactions for the formation of C–C bonds. It is based on organotin compoun...
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Organocatalytic upgrading of biomass-derived furaldehydes: An emerging chemical technology for biorefineries Synth. Commun. (IF 2.1) Pub Date : 2023-10-18 Rafik Rajjak Shaikh, S. Thenmozhi
Identifying novel and highly efficient catalytic processes for biomass to commercially important products is crucial to find economically friendly options for biorefineries. Despite decades of effo...
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CobaltII phthalocyanine catalyzed efficient synthesis of substituted 1-phenyl-1-propanone from ketones with primary alcohols (α-alkylation) Synth. Commun. (IF 2.1) Pub Date : 2023-10-18 Anshu Dandia, Shive M. S. Chauhan
Herein, we report the cobalt(II) phthalocyanine catalyzed one-pot α-alkylation reaction of ketones with primary alcohols to provide the substituted 1-phenyl-1-propanone as the desired compound. We ...
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An efficient one-pot multicomponent, Amberlite IR120(H) catalyzed microwave-assisted synthesis of 1,2,4,5-tetrasubstituted-1H-imidazoles: Plausible mechanism and antibacterial evaluation Synth. Commun. (IF 2.1) Pub Date : 2023-10-18 Shailesh S. Gurav, Seema R. Jadhav, Suraj N. Mali, Onkar A. Lotlikar, Krishnakant T. Waghmode
The present study describes an efficient and convenient one-pot multicomponent, microwave-assisted synthesis of polysubstituted-1H-imidazoles in good yields under mild reaction conditions. The proc...