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Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2021-01-05 Domenico Rizzo; Enrico Ravera; Marco Fragai; Giacomo Parigi; Claudio Luchinat
Magnetic resonance imaging (MRI) often requires contrast agents to improve the visualization in some tissues and organs, including the gastrointestinal tract. In this latter case, instead of intravascular administration, oral agents can be used. Natural oral contrast agents, such as fruit juice, have the advantages of better taste, tolerability, and lower price with respect to the artificial agents
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Novel Gallium(III), Germanium(IV), and Hafnium(IV) Folate Complexes and Their Spectroscopic, Thermal Decomposition, Morphological, and Biological Characteristics Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-12-21 Abeer A. El-Habeeb
In this study, we describe novel gallium(III), germanium(IV), and hafnium(IV) folate complexes, including their synthesis and analyses. The synthesized folate complexes were also subject to thermal analysis (TGA) to better examine their thermal degradation and kinetic properties. The folate complexes had high stability and were nonspontaneous. The Coats–Redfern and Horowitz–Metzger equations were used
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Atmospheric Corrosion, Antibacterial Properties, and Toxicity of Silver Nanoparticles Synthesized by Two Different Routes Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-12-10 I. DeAlba-Montero; Claudio A. Ruiz-Torres; Diana P. Portales-Pérez; Fidel Martínez-Gutierrez; Félix Echeverría; Martha E. Compeán-Jasso; Yolanda G. Cataño-Cañizales; Facundo Ruiz
Silver nanoparticles (AgNPs) have been widely employed or incorporated into different materials in biological application, due to their antibacterial properties. Therefore, antimicrobial capacity and cytotoxicity have been highly studied. However, most of these reports do not consider the possible corrosion of the nanomaterials during their exposure to atmospheric conditions since AgNPs undergo a transformation
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Synthesis and Characterization of Green Zinc Oxide Nanoparticles with Antiproliferative Effects through Apoptosis Induction and MicroRNA Modulation in Breast Cancer Cells Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-11-20 Amir Hossein Aalami; Mohammad Mesgari; Amirhossein Sahebkar
Changes in the expression of microRNAs can affect cancer cells’ viability and behavior and the impact on cancer treatment. In this study, the expression of miR-155-5p, miR-203a-3p, and miR-223-3p in the MCF7 cancer cell line was studied when exposed to ZnO nanoparticles synthesized through a green route. Mentioned ZnO-NPs were well characterized by UV-vis spectroscopy, DLS, XRD, FTIR, FE-SEM, EDX,
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Synthesis and Biological Evaluation of Novel Zn(II) and Cd(II) Schiff Base Complexes as Antimicrobial, Antifungal, and Antioxidant Agents Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-11-19 Mutlaq S. Aljahdali; Ahmed A. El-Sherif
(E)-N,N-Dimethyl-2-((E-1-(2-(p-tolyl)hydrazono)propan-2-ylidene)hydrazine-1-carbothioamide (DMPTHP) and their Zn(II) and Cd(II) complexes have been synthesized and characterized. Different tools of analysis such as elemental analyses, IR, mass spectra, and 1H-NMR measurements were used to elucidate the structure of the synthesized compounds. According to these spectral results, the DMPTHP ligand behaved
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Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-09-29 Yang Li; Jianfang Dong; Peiran Zhao; Ping Hu; Dawei Yang; Lei Gao; Lianzhi Li
Three hexacoordinated octahedral nickel (II) complexes, [Ni (Trp-sal) (phen) (CH3OH)] (1), [Ni (Trp-o-van) (phen) (CH3OH)]•2CH3OH (2), and [Ni (Trp-naph) (phen) (CH3OH)] (3) (where Trp-sal = Schiff base derived from tryptophan and salicylaldehyde, Trp-o-van = Schiff base derived from tryptophan and o-vanillin, Trp-naph = Schiff base derived from tryptophan and 2-hydroxy-1-naphthaldehyde, phen = 1,
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Boswellia dalzielii-Mediated Silver Nanoparticles Inhibited Acute Myeloid Leukemia (AML) Kasumi-1 Cells by Inducing Cell Cycle Arrest Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-09-22 Ismail Abiola Adebayo; Adamu Ibrahim Usman; Fatimah Bukola Shittu; Noor Zafirah Ismail; Hasni Arsad; Taoheed Kolawole Muftaudeen; Mohammed Razip Samian
Background. Acute myeloid leukemia (AML) persists to be a major health problem especially among children as effective chemotherapy to combat the disease is yet to be available. Boswellia dalzielii is a well-known herb that is traditionally used for treatment and management of many diseases including degenerative diseases. In this study, silver nanoparticles were synthesized from the phytochemicals
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Sealing Ability of AH Plus and GuttaFlow Bioseal Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-09-22 Soo-Hyuk Lee; Soram Oh; Adel Saeed Al-Ghamdi; Ayman Omar Mandorah; Kee-Yeon Kum; Seok Woo Chang
The objective of root canal obturation is to achieve a fluid-tight seal. Recently, GuttaFlow bioseal (GB), a root canal sealer composed of polydimethylsiloxane, gutta-percha particles, and bioactive glass ceramics, has been developed, to enhance the sealing ability of root canal filling material. The objective of this study was to assess the sealing ability of GB using a subnanoliter-scaled fluid-flow
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Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-09-15 Zou Xun-Zhong; Feng An-Sheng; Zeng Fu-Ran; Lai Min-Cheng; Liao Yan-Zhi; Mei Meng; Li Yu
Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between α-haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray
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Glutaraldehyde-Polymerized Hemoglobin: In Search of Improved Performance as Oxygen Carrier in Hemorrhage Models. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-09-01 Anca D Farcas,Vlad Al Toma,Ioana Roman,Bogdan Sevastre,Florina Scurtu,Radu Silaghi-Dumitrescu
Hemoglobin- (Hb-) based oxygen carriers (HBOC) have for several decades been explored for treatment of hemorrhage. In our previous top-up tests, HBOC with lower in vitro prooxidant reactivity (incorporating a peroxidase or serum albumin to this end) showed a measurable but small improvement of oxidative stress-related parameters. Here, such HBOCs are tested in a hemorrhage set-up; ovine hemoglobin
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Effect of Ultrafine Powderization and Solid Dispersion Formation via Hot-Melt Extrusion on Antioxidant, Anti-Inflammatory, and the Human Kv1.3 Channel Inhibitory Activities of Angelica gigas Nakai. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-09-01 Yunyao Jiang,Jingpei Piao,Nan Liu,Jincai Hou,Jianxun Liu,Weicheng Hu
Angelica gigas Nakai (AGN) was first processed by ultrafine grinding technology and hot-melt extrusion (HME). The potential antioxidant and anti-inflammatory activities of AGN with a different process were compared, and the effect on the human Kv1.3 potassium channel was detected. The process of ultrafine powderization on AGN significantly increased the total phenolic and flavonoid contents, antioxidant
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Determination of Physicochemical Parameters and Levels of Heavy Metals in Food Waste Water with Environmental Effects. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-08-20 Jingxi Ma,Shuqing Wu,N V Ravi Shekhar,Supriya Biswas,Anoop Kumar Sahu
Bioinorganic chemistry is found as a sizzling field in today’s era. It deals with chemistry amongst the heavy metals with natural resources, i.e., air, soil, water, plant byproducts (foods), and environmental essences. The aim of this research is to determine the concentration of heavy metals present in the food waste water sample and to study the environmental effects of metal ion concentration. To
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Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-08-17 Jincan Chen,Jie Wang,Yuanyuan Deng,Tao Wang,Tifang Miao,Chengpeng Li,Xianhong Cai,Ying Liu,Justin Henri,Lanmei Chen
Two new Ru(II) complexes containing O, O-chelated ligands, Ru(dip)2(SA) (Ru-1) and Ru(dmp)2(SA) (Ru-2) (dip = 4,7-diphenyl-1,10-phenanthroline; dmp = 2,9-dimethyl-1,10-phenanthroline; SA = salicylate) were synthesized to evaluate their cytotoxicity in vitro. These complexes were found to exhibit moderate antitumor activity to different types of human cancers, including A549 (human lung carcinoma),
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Therapeutic Use of Silver Nanoparticles in the Prevention and Arrest of Dental Caries. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-08-12 Claudia Butrón Téllez Girón,Juan F Hernández Sierra,Idania DeAlba-Montero,María de Los A Urbano Peña,Facundo Ruiz
Dental caries is one of the major diseases of the oral cavity affecting humans worldwide. Different alternatives have been used for its control, but its incidence and prevalence are still high. On the other hand, silver has been used for centuries due to its antimicrobial properties. With advances in nanotechnology, the use and research in nanomaterials has increased, recently, and silver nanoparticles
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Adsorption Ability for Toxic Chromium (VI) Ions in Aqueous Solution of Some Modified Oyster Shell Types Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-07-27 Thuy Chinh Nguyen; Xuan Thai Nguyen; Do Mai Trang Tran; Quoc Trung Vu; Van Hai Nguyen; Duy Trinh Nguyen; Minh Thanh Do; Thi Len Nguyen; Thi Ngoc Lien Ly; Hoang Thai
In this paper, the chromium, Cr (VI), ion adsorption ability of oyster shell samples collected from two sea regions in Vietnam (Phu Yen province and Quang Ninh province) was investigated and compared. The oyster shell samples were calcined at different temperatures and denatured by using ethylenediaminetetraacetic acid (EDTA). The Cr (VI) ion adsorption ability of the prismatic (PP) and nacreous (NP)
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Silver Nanoparticle Production by Ruta graveolens and Testing Its Safety, Bioactivity, Immune Modulation, Anticancer, and Insecticidal Potentials. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-07-24 Hamed A Ghramh,Essam H Ibrahim,Mona Kilnay,Zubair Ahmad,Sadeq K Alhag,Khalid Ali Khan,Ramadan Taha,Fawziah M Asiri
Ruta graveolens, a plant belonging to the family Rutaceae, is traditionally used as a medicinal plant and a flavoring agent in food. This work aimed to prepare silver nanoparticles (AgNPs) using the ethanol extract from R. graveolens leaves and test different biological activities as well as insecticidal potentials in the extract and extract prepared AgNPs. Dried and powdered R. graveolens leaves were
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Dynamic and Static Nature of Br4 σ(4c-6e) and Se2Br5 σ(7c-10e) in the Selenanthrene System and Related Species Elucidated by QTAIM Dual Functional Analysis with QC Calculations. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-07-24 Satoko Hayashi,Taro Nishide,Waro Nakanishi
The nature of Br4σ(4c–6e) of the BBr-∗-ABr-∗-ABr-∗-BBr form is elucidated for SeC12H8(Br)SeBr---Br-Br---BrSe(Br)C12H8Se, the selenanthrene system, and the models with QTAIM dual functional analysis (QTAIM-DFA). Asterisks (∗) are employed to emphasize the existence of bond critical points on the interactions in question. Data from the fully optimized structure correspond to the static nature of interactions
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Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-04-14 Sonja Ž Đurić,Sandra Vojnovic,Tina P Andrejević,Nevena Lj Stevanović,Nada D Savić,Jasmina Nikodinovic-Runic,Biljana Đ Glišić,Miloš I Djuran
1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO3}n (1), {[Ag(bpa)2]CF3SO3.H2O}n (2) and {[Ag(bpe)]CF3SO3}n (3). In complexes 1–3, the corresponding nitrogen-containing heterocycle acts as a bridging ligand between two Ag(I) ions. In vitro antimicrobial activity of these complexes, along with the ligands used
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The Response of the Pulp-Dentine Complex, PDL, and Bone to Three Calcium Silicate-Based Cements: A Histological Study in an Animal Rat Model. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-04-13 Ranjdar Mahmood Talabani,Balkees Taha Garib,Reza Masaeli
Objective. The aim of this study was to histologically examine the tissue reaction of three different calcium silicate cements in the closure of perforations in rat incisor teeth. Material and Methods. An experimental lateral root perforation with pulp exposure was performed in 32 lower incisors of 16 male Wistar albino rats. They were randomly assigned into three test groups (each including eight
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High Throughput Approaches to Unravel the Mechanism of Action of a New Vanadium-Based Compound against Trypanosoma cruzi. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-04-11 M Florencia Mosquillo,Pablo Smircich,Analía Lima,Sergio A Gehrke,Gonzalo Scalese,Ignacio Machado,Dinorah Gambino,Beatriz Garat,Leticia Pérez-Díaz
Treatment for Chagas disease, a parasitosis caused by Trypanosoma cruzi, has always been based on two drugs, nifurtimox and benznidazole, despite the toxic side effects described after prolonged prescription. In this work, we study a new prospective antitrypanosomal drug based on vanadium, here named VIVO(5Brsal)(aminophen). We found a good IC50 value, (3.76 ± 0.08) μM, on CL Brener epimastigotes.
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Antioxidant Properties of Lapachol and Its Derivatives and Their Ability to Chelate Iron (II) Cation: DFT and QTAIM Studies. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2020-03-31 Djafarou Ngouh Pajoudoro,Daniel Lissouck,Baruch Ateba Amana,Joseph Zobo Mfomo,A E B Abdallah,Alfred Aristide Flavien Toze,Désiré Bikele Mama
The elucidation of the complexation of lapachol and its derivatives to Fe2+ cation has been done using the density functional theory (DFT). This complexation has been limited to bidentate and tridentate to Fe2+ cation. Geometry optimizations have been implemented in gas and solution phase (water, acetonitrile, chlorobenzene, benzene, and toluene) for ligands at B3LYP/6-311++G (d,p) level of theory
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Corrigendum to "Effect of Carboxylic Functional Group Functionalized on Carbon Nanotubes Surface on the Removal of Lead from Water". Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-11-15 Muataz Ali Atieh,Omer Yehya Bakather,Bassam Tawabini,Alaadin A Bukhari,Faraj Ahmad Abuilaiwi,Mohamed B Fettouhi
[This corrects the article DOI: 10.1155/2010/603978.].
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Corrigendum to "Formation of Silver Nanoclusters from a DNA Template Containing Ag(I)-Mediated Base Pairs". Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-07-24 J Christian Léon,Linda Stegemann,Martin Peterlechner,Stefanie Litau,Gerhard Wilde,Cristian A Strassert,Jens Müller
[This corrects the article DOI: 10.1155/2016/7485125.].
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Metals in the Environment: Toxic Metals Removal. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2017-08-10 Muataz A Atieh,Yun Ji,Viktor Kochkodan
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Impact of Molybdenum Compounds as Anticancer Agents. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2019-09-10 Ayodele T Odularu,Peter A Ajibade,Johannes Z Mbese
The aim of this mini review was to report the molybdenum compound intervention to control cancer disease. The intervention explains its roles and progress from inorganic molybdenum compounds via organomolybdenum complexes to its nanoparticles to control oesophageal cancer and breast cancer as case studies. Main contributions of molybdenum compounds as anticancer agents could be observed in their nanofibrous
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Mg-Al Mixed Oxide Adsorbent Synthesized Using FCT Template for Fluoride Removal from Drinking Water. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2019-07-07 Jifa Liu,Ping Zhao,Yue Xu,Xibin Jia
To make full use of natural waste, a novel Mg-Al mixed oxide adsorbent was synthesized by the dip-calcination method using the fluff of the chinar tree (FCT) and an Mg(II) and Al(III) chloride solution as raw materials. The adsorbents were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, and X-ray photoelectron spectroscopy
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Antibacterial Effect of Silver Nanoparticles Synthesized Using Murraya koenigii (L.) against Multidrug-Resistant Pathogens. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2019-07-01 Faizan Abul Qais,Anam Shafiq,Haris M Khan,Fohad M Husain,Rais A Khan,Bader Alenazi,Ali Alsalme,Iqbal Ahmad
Development of multidrug resistance among pathogens has become a global problem for chemotherapy of bacterial infections. Extended-spectrum β-lactamase- (ESβL-) producing enteric bacteria and methicillin-resistant Staphylococcus aureus (MRSA) are the two major groups of problematic MDR bacteria that have evolved rapidly in the recent past. In this study, the aqueous extract of Murraya koenigii leaves
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Cu(II) and Ni(II) Complexes with New Tridentate NNS Thiosemicarbazones: Synthesis, Characterisation, DNA Interaction, and Antibacterial Activity. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2019-07-01 Dorian Polo-Cerón
This paper reports the synthesis and detailed characterisation of copper(II) and nickel(II) complexes with tridentate thiosemicarbazone ligands H2L1 and H2L2 derived from 2-acetylpyrazine. The ligands and their metal complexes were characterised by different physicochemical techniques, including elemental and thermogravimetric analysis; UV-Vis, IR, 1H-NMR, and 13C-NMR spectroscopy; molar conductance
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Nonfunctionalized Cation of an Ionic Liquid as a Ligand in the Synthesis of a New Coordination Compound and Assessment of Its Biological Activity. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2019-06-24 Getinet Tamiru Tigineh,Atakilt Abebe
Literature evidences reveal the affinity of ionic liquids for biomembranes that they are readily absorbed into the cell, resulting in a variety of biological effects, including broad antibacterial potential and anticancer activity. Recent research directions considered the ions of this class of compounds as a new choice of ligands in the synthesis of transition metal complexes for various applications
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Effects of N-Terminal and C-Terminal Polyhistidine Tag on the Stability and Function of the Thermophilic P450 CYP119. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2019-06-20 Yaprak Aslantas,Nur Basak Surmeli
Biocatalysts are sought-after in synthesis of pharmaceuticals and agrochemicals due to their high regioselectivity and enantioselectivity. Among biocatalysts, heme-containing cytochrome P450 (P450) oxygenases are an attractive target since they catalyze oxidation of “unactivated” carbon-hydrogen bonds with high efficiency. CYP119 is an acidothermophilic P450 from Sulfolobus acidocaldarius, which has
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Encapsulation of Gold Nanorods with Porphyrins for the Potential Treatment of Cancer and Bacterial Diseases: A Critical Review. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2019-04-30 Nthabeleng Hlapisi,Tshwafo E Motaung,Linda Z Linganiso,Oluwatobi S Oluwafemi,Sandile P Songca
Cancer and bacterial diseases have been the most incidental diseases to date. According to the World Health Report 2018, at least every family is affected by cancer around the world. In 2012, 14.1 million people were affected by cancer, and that figure is bound to increase to 21.6 million in 2030. Medicine therefore sorts out ways of treatment using conventional methods which have been proven to have
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Bioremoval of Cobalt(II) from Aqueous Solution by Three Different and Resistant Fungal Biomasses. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2019-04-17 Juan F Cárdenas González,Adriana S Rodríguez Pérez,Juan M Vargas Morales,Víctor M Martínez Juárez,Ismael Acosta Rodríguez,Christian Michel Cuello,Gustavo Gallegos Fonseca,Milka E Escalera Chávez,Alejandra Muñoz Morales
The biosorption of Co(II) on three fungal biomasses: Paecilomyces sp., Penicillium sp., and Aspergillus niger, was studied in this work. The fungal biomass of Paecilomyces sp. showed the best results, since it removes 93% at 24 h of incubation, while the biomasses of Penicillium sp. and Aspergillus niger are less efficient, since they remove the metal 77.5% and 70%, respectively, in the same time of
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Dithiocarbamates: Challenges, Control, and Approaches to Excellent Yield, Characterization, and Their Biological Applications. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2019-02-06 Ayodele T Odularu,Peter A Ajibade
Progresses made in previous researches on syntheses of dithiocarbamates led to increase in further researches. This paper reviews concisely the challenges experienced during the synthesis of dithiocarbamate and mechanisms to overcome them in order to obtain accurate results. Aspects of its precursor’s uses to synthesize adducts, nanoparticles, and nanocomposites are reported. Some common characterization
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Eco-Efficient Biosorbent Based on Leucaena leucocephala Residues for the Simultaneous Removal of Pb(II) and Cd(II) Ions from Water System: Sorption and Mechanism. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2019-01-02 C A Cimá-Mukul,Youness Abdellaoui,Mohamed Abatal,Joel Vargas,Arlette A Santiago,Jesús Alberto Barrón-Zambrano
Leucaena leucocephala is a potential source of polyphenols widely available in southern Mexico. This work highlights the extraction of polyphenols from Leucaena leucocephala leaves waste (LLEPs) and the evaluation of their efficiency to remove the single and multicomponent Pb(II) and Cd(II) metal ions from aqueous solutions. Batch test conditions were carried out to examine the effects of contact time
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Synthesis and Antibacterial Activity of Polyoxometalates with Different Structures. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-12-09 Jingmin Gu,Lei Zhang,Xiaofeng Yuan,Ya-Guang Chen,Xiuzhu Gao,Dong Li
A new inorganic-organic hybrid compound, [{Cu(phen)2}2(H4W12O40)], was synthesized, and its crystal structure was determined. The Keggin anion H4W12O404− was grafted with two coordination units {Cu(phen)2}, forming an electrically neutral molecule. The antibacterial activity of several polyoxometalate compounds with different anionic structures including the new compound was studied. The results show
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The Structures, Spectroscopic Properties, and Photodynamic Reactions of Three [RuCl(QN)NO]- Complexes (HQN = 8-Hydroxyquinoline and Its Derivatives) as Potential NO-Donating Drugs. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-12-02 Leilei Xie,Lifang Liu,Wenming Wang,Zhiou Ma,Liqun Xu,Xuan Zhao,Hongfei Wang
The structures and spectral properties of three ruthenium complexes with 8-hydroxyquinoline (Hhqn) and their derivatives 2-methyl-8-quinolinoline (H2mqn) and 2-chloro-8-quiolinoline (H2cqn) as ligands (QN = hqn, 2mqn, or 2cqn) were calculated with density functional theory (DFT) at the B3LYP level. The UV-Vis and IR spectra of the three [RuCl(QN)NO]− complexes were theoretically assigned via DFT calculations
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Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA). Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-11-01 Ebtesam S Al-Sheddi,Nida N Farshori,Mai M Al-Oqail,Shaza M Al-Massarani,Quaiser Saquib,Rizwan Wahab,Javed Musarrat,Abdulaziz A Al-Khedhairy,Maqsood A Siddiqui
In this study, silver nanoparticles (AgNPs) were synthesized using aqueous extract of Nepeta deflersiana plant. The prepared AgNPs (ND-AgNPs) were examined by ultraviolet-visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscope (SEM), and energy dispersive spectroscopy (EDX). The results obtained
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Bioremoval of Different Heavy Metals by the Resistant Fungal Strain Aspergillus niger. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-11-01 Ismael Acosta-Rodríguez,Juan F Cárdenas-González,Adriana S Rodríguez Pérez,Juana Tovar Oviedo,Víctor M Martínez-Juárez
The objective of this work was to study the resistance and removal capacity of heavy metals by the fungus Aspergillus niger. We analyzed the resistance to some heavy metals by dry weight and plate: the fungus grew in 2000 ppm of zinc, lead, and mercury, 1200 and 1000 ppm of arsenic (III) and (VI), 800 ppm of fluor and cobalt, and least in cadmium (400 ppm). With respect to their potential of removal
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Optimization Studies on Recovery of Metals from Printed Circuit Board Waste. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-11-01 P Sivakumar,D Prabhakaran,M Thirumarimurugan
The aim of the study was to recover copper and lead metal from waste printed circuit boards (PCBs). The electrowinning method is found to be an effective recycling process to recover copper and lead metal from printed circuit board wastes. In order to simplify the process with affordable equipment, a simple ammonical leaching operation method was adopted. The selected PCBs were incinerated into fine
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Biogenic Synthesis of Copper and Silver Nanoparticles Using Green Alga Botryococcus braunii and Its Antimicrobial Activity. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-10-21 Anju Arya,Khushbu Gupta,Tejpal Singh Chundawat,Dipti Vaya
The spread of infectious diseases and the increase in the drug resistance among microbes has forced the researchers to synthesize biologically active nanoparticles. Improvement of the ecofriendly procedure for the synthesis of nanoparticles is growing day-by-day in the field of nanobiotechnology. In the present study, we use the extract of green alga Botryococcus braunii for the synthesis of copper
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Cytotoxic and Bactericidal Effect of Silver Nanoparticles Obtained by Green Synthesis Method Using Annona muricata Aqueous Extract and Functionalized with 5-Fluorouracil. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-10-15 María Del Carmen Sánchez-Navarro,Claudio Adrian Ruiz-Torres,Nereyda Niño-Martínez,Roberto Sánchez-Sánchez,Gabriel Alejandro Martínez-Castañón,I DeAlba-Montero,Facundo Ruiz
Nanomaterials obtained by green synthesis technologies have been widely studied in recent years owing to constitute cost-effective and environmental-friendly methods. In addition, there are several works that report the simultaneous performance of the reducer agent as a functionalizing agent, modifying the properties of the nanomaterial. As a simple and economical synthesis methodology, this work presents
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Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-10-01 Xuejiao Li,Yahong Liu,Hongqi Tian
To overcome the side effects of and resistance to cisplatin, a variety of Pt(IV) prodrugs were designed and synthesized via different modifications including combination with lipid chains to increase hydrophobicity, conjugation with short peptide chains or nanoparticles to improve drug delivery, or addition of bioactive ligands to the axial positions of Pt(IV) complexes to exert dual-function effects
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Structural Properties and Reactive Site Selectivity of Some Transition Metal Complexes of 2,2'(1E,1'E)-(ethane-1,2-diylbis(azan-1-yl-1-ylidene))bis(phenylmethan-1-yl-1-ylidene)dibenzoic Acid: DFT, Conceptual DFT, QTAIM, and MEP Studies. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-09-26 Fritzgerald Kogge Bine,Nyiang Kennet Nkungli,Tasheh Stanley Numbonui,Julius Numbonui Ghogomu
Herein is presented a density functional theory (DFT) study of reactivity and structural properties of transition metal complexes of the Schiff base ligand 2,2′(1E,1′E)-(ethane-1,2-diylbis(azan-1-yl-1-ylidene))bis(phenylmethan-1-yl-1-ylidene)dibenzoic acid (hereafter denoted EDA2BB) with Cu(II), Mn(II), Ni(II), and Co(II). The quantum theory of atoms-in-molecules (QTAIM), conceptual DFT, natural population
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Study on Adsorption of Cu and Ba from Aqueous Solutions Using Nanoparticles of Origanum (OR) and Lavandula (LV). Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-09-09 Ghadah M Al-Senani,Foziah F Al-Fawzan
Wild herbs (Origanum (OR) and Lavandula (LV)) were used as environment-friendly adsorbents in this study. The adsorbents were used for adsorption of Cu and Ba from water. The adsorption of heavy metals onto OR and LV was dependent on particle size, dose, and solution pH. The diameter of adsorbent particles was less than 282.8 nm. The adsorption follows second-order kinetics. Langmuir and Freundlich
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Synthesis of Novel VO(II)-Perimidine Complexes: Spectral, Computational, and Antitumor Studies. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-09-06 Gamil A Al-Hazmi,Khlood S Abou-Melha,Nashwa M El-Metwaly,Kamel A Saleh
A series of perimidine derivatives (L1–5) were prepared and characterized by IR, 1H·NMR, mass spectroscopy, UV-Vis, XRD, thermal, and SEM analysis. Five VO(II) complexes were synthesized and investigated by most previous tools besides the theoretical usage. A neutral tetradentate mode of bonding is the general approach for all binding ligands towards bi-vanadyl atoms. A square-pyramidal is the configuration
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Synthesis and Characterization of trans-Dichlorotetrakis(imidazole)cobalt(III) Chloride: A New Cobalt(III) Coordination Complex with Potential Prodrug Properties. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-09-03 Kaila F Hart,Natalie S Joe,Rebecca M Miller,Hannah P Nash,David J Blake,Aimee M Morris
Numerous therapies for the treatment of cancer have been explored with increasing evidence that the use of metal-containing compounds could prove advantageous as anticancer therapeutics. Previous works on Ru(III) complexes suggest that structurally similar Co(III) complexes may provide good alternative, low-cost, effective prodrugs. Herein, a new complex, trans-[Co(imidazole)4Cl2]Cl (2), has been synthesized
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Synthesis, Characterization, and Antimicrobial Activity of Novel Sulfonated Copper-Triazine Complexes. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-08-29 Supun Katugampala,Inoka C Perera,Chandrika Nanayakkara,Theshini Perera
Metallotriazine complexes possess interesting biological and medicinal properties, and the present study focuses on the synthesis, characterization, and antimicrobial activity of four novel copper-triazine derivatives in search of potent antibacterial and antifungal drug leads. In this study, 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4,4′-disulfonic acid monosodium salt (L1, ferrozine) and 3-(2-pyridyl)-5
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An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-08-12 Aiten Ismailova,David Kuter,D Scott Bohle,Ian S Butler
Carbon monoxide (CO) has long been known as the “silent killer” owing to its ability to form carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely examined via both the direct administration of CO and in the form of so-called “carbon monoxide releasing
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Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-08-01 Abdullah-Al Masum,Yosuke Hisamatsu,Kenta Yokoi,Shin Aoki
Death receptors (DR4 and DR5) offer attractive targets for cancer treatment because cancer cell death can be induced by apoptotic signal upon binding of death ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with death receptors. Cyclometalated iridium(III) complexes such as fac-Ir(tpy)3 (tpy = 2-(4-tolyl)pyridine) possess a C3-symmetric structure like TRAIL and exhibit
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A Review on Green Synthesis, Biomedical Applications, and Toxicity Studies of ZnO NPs. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-08-01 V N Kalpana,V Devi Rajeswari
The advance of reliable and eco-friendly strategies for the development of nanoparticles is a fundamental key to the discipline of nanotechnology. Nanoparticles have been continuously evaluated and have been used in many industrial applications for a decade. In particular, the role of zinc oxide nanoparticles (ZnO NPs) has received a great interest because of various properties such as UV filter properties
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Biomimetic Approach to CO2 Reduction. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-08-01 Ilaria Gamba
The development of artificial photosynthetic technologies able to produce solar-fuels from CO2 reduction is a fundamental task that requires the employment of specific catalysts being accomplished. Besides, effective catalysts are also demanded to capture atmospheric CO2, mitigating the effects of its constantly increasing emission. Biomimetic transition metal complexes are considered ideal platforms
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Structure-Based Drug Design for Cytochrome P450 Family 1 Inhibitors. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-07-25 Zbigniew Dutkiewicz,Renata Mikstacka
Cytochromes P450 are a class of metalloproteins which are responsible for electron transfer in a wide spectrum of reactions including metabolic biotransformation of endogenous and exogenous substrates. The superfamily of cytochromes P450 consists of families and subfamilies which are characterized by a specific structure and substrate specificity. Cytochromes P450 family 1 (CYP1s) play a distinctive
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Synthesis of N-Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-07-17 Atakilt Abebe,Minaleshewa Atlabachew,Misganaw Liyew,Elsabet Ferede
New organic salts were synthesized by quaternizing 1,10-phenanthroline using 1-bromotetradecane. The first step yielded an organic salt of formula [C26H37N2]Br. Anion exchange reaction using Li[(CF3SO2)2N] resulted in a more stable salt of formula [C26H37N2][(CF3SO2)2N]. The organic salts were investigated by spectrometry (1H, 13C, 19F NMR, X-ray photoelectron spectroscopy (XPS), UV-Vis, and matrix-assisted
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The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-07-05 Jinhuan Jiang,Jiang Pi,Jiye Cai
Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. ZnO NPs have emerged a promising potential in biomedicine, especially in
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Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-07-05 Peiran Zhao,Shanshan Zhai,Jianfang Dong,Lei Gao,Xinru Liu,Lei Wang,Jinming Kong,Lianzhi Li
Three hexacoordinated octahedral nickel(II) complexes, [Ni(sal-L-phe)(phen)(CH3OH)]⋅CH3OH (1), [Ni(naph-L-phe)(phen)(CH3OH)] (2), and [Ni(o-van-L-phe)(phen)(CH3OH)]⋅5CH3OH (3) (sal-L-phe = a Schiff base derived from salicylaldehyde and L-phenylalanine, naph-L-phe = a Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, o-van-L-phe = a Schiff base derived from o-vanillin and L-phenylalanine
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Study of Isothermal, Kinetic, and Thermodynamic Parameters for Adsorption of Cadmium: An Overview of Linear and Nonlinear Approach and Error Analysis. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-07-03 Fozia Batool,Jamshed Akbar,Shahid Iqbal,Sobia Noreen,Syed Nasir Abbas Bukhari
Reports about presence and toxicity of Cd2+ in different chemical industrial effluents prompted the researchers to explore some economical, rapid, sensitive, and accurate methods for its determination and removal from aqueous systems. In continuation of series of investigations, adsorption of Cd2+ onto the stem of Saccharum arundinaceum is proposed in the present work. Optimization of parameters affecting
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Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-07-02 Shalaka S Rokade,Komal A Joshi,Ketakee Mahajan,Saniya Patil,Geetanjali Tomar,Dnyanesh S Dubal,Vijay Singh Parihar,Rohini Kitture,Jayesh R Bellare,Sougata Ghosh
Green chemistry approaches for designing therapeutically significant nanomedicine have gained considerable attention in the past decade. Herein, we report for the first time on anticancer potential of phytogenic platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using a medicinal plant Gloriosa superba tuber extract (GSTE). The synthesis of the nanoparticles was completed within 5 hours
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A Diversified Spectrometric and Molecular Docking Technique to Biophysical Study of Interaction between Bovine Serum Albumin and Sodium Salt of Risedronic Acid, a Bisphosphonate for Skeletal Disorders. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-06-28 M Manjushree,Hosakere D Revanasiddappa
The binding interaction between bovine serum albumin (BSA) and sodium salt of risedronic acid (RSN) was studied by using the FT-IR (Fourier transform infrared), UV-Vis (ultraviolet–visible), fluorescence (emission and synchronous), CD (circular dichroism) spectrometric, and computational (molecular docking) techniques at 289, 297, and 305 K temperatures with physiological buffer of pH 7.40. The conformational
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Synthesis and Characterization of Oxidovanadium(IV) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol and Their Antimicrobial, Antioxidant, and DNA-Binding Studies. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-06-27 K Savithri,H D Revanasiddappa
Two novel oxidovanadium(IV) complexes with a new bidentate (O- and N-) imine-based ligand 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol (HL) were synthesized under in situ experimental condition where VOSO4 acts as a kinetic template in the ratio 2 : 1 (L : M) and mixed ligand complex using 1,10-phenanthroline (phen) in 1 : 1 : 1 (L : M : phen) ratio. The synthesized compounds were
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Pharmacological and Toxicological Threshold of Bisammonium Tetrakis 4-(N,N-Dimethylamino)pyridinium Decavanadate in a Rat Model of Metabolic Syndrome and Insulin Resistance. Bioinorg. Chem. Appl. (IF 3.273) Pub Date : 2018-06-19 Samuel Treviño,Alfonso Díaz,Eduardo Sánchez-Lara,Víctor Enrique Sarmiento-Ortega,José Ángel Flores-Hernández,Eduardo Brambila,Francisco J Meléndez,Enrique González-Vergara
Vanadium(IV/V) compounds have been studied as possible metallopharmaceutical drugs against diabetes mellitus. However, mechanisms of action and toxicological threshold have been tackled poorly so far. In this paper, our purposes were to evaluate the metabolic activity on dyslipidemia and dysglycemia, insulin signaling in liver and adipose tissue, and toxicology of the title compound. To do so, the
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