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Mononuclear η6-arene ruthenium(II) complexes with pyrazolyl–pyridazine ligands: synthesis, CT-DNA binding, reactivity towards glutathione, and cytotoxicity J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2024-03-17 Amos K. Kanyora, Reinner O. Omondi, Peter Ongoma, Josiah O. Omolo, Athi Welsh, Sharon Prince, Joel Gichumbi, Allen Mambanda, Gregory S. Smith
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Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2024-03-12 Thomas C. Chin, Sigurd M. Wilbanks, Elizabeth C. Ledgerwood
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Cytotoxicity of bismuth(III) dithiocarbamate derivatives by promoting a mitochondrial-dependent apoptotic pathway and suppressing MCF-7 breast adenocarcinoma cell invasion J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2024-02-18 Pit Foong Chan, Kok Pian Ang, Roslida Abd Hamid
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Effect of Pb-exposure and B vitamin deficiencies on δ-aminolevulinic acid dehydratase activity among workers from Pb recycling plants J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2024-01-30
Abstract Previous studies reported that Pb exposure causes a negative association with delta-aminolevulinic acid dehydratase activity (δ-ALAD), but the impact of Pb exposure (dose and time), B vitamin deficiencies, and lifestyle factors needs to be explored. In this study, the impact of Pb exposure, B vitamin deficiencies, and lifestyle factors on δ-ALAD activity among workers exposed to Pb from the
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Spectroscopic and computational investigations of Cobalt(II) binding to the innate immune protein human calprotectin J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2024-01-17
Abstract Human calprotectin (CP) is an innate immune protein that participates in the metal-withholding response to infection by sequestering essential metal nutrients from invading microbial pathogens. CP is comprised of S100A8 (α subunit, 10.8 kDa) and S100A9 (β subunit, 13.2 kDa). Two transition-metal binding sites of CP form at the S100A8/S100A9 dimer interface. Site 1 is a His3Asp motif comprised
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Flexible active-site loops fine-tune substrate specificity of hyperthermophilic metallo-oxidases J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2024-01-16 Vânia Brissos, Patrícia T. Borges, Ferran Sancho, Maria Fátima Lucas, Carlos Frazão, Felipe Conzuelo, Lígia O. Martins
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Lysosome-targeted ruthenium(II) complex encapsulated with pluronic® F-127 induces oncosis in A549 cells J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2024-01-08 Nanlian Pan, Yuqing Zhang, Minying Huang, Zhijun Liang, Yao Gong, Xide Chen, Yuling Li, Ciling Wu, Zunnan Huang, Jing Sun
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Phototoxicity of cyclometallated Ir(III) complexes bearing a thio-bis-benzimidazole ligand, and its monodentate analogue, as potential PDT photosensitisers in cancer cell killing J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2024-01-06 Marta Martínez-Alonso, Callum G. Jones, James D. Shipp, Dimitri Chekulaev, Helen E. Bryant, Julia A. Weinstein
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Ruthenium(II) complex with 2-mercaptothiazoline ligand induces selective cytotoxicity involving DNA damage and apoptosis in melanoma cells J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2024-01-05 Matheus Reis Santos de Melo, Arthur Barcelos Ribeiro, Gabriela Fernandes, Iara Silva Squarisi, Marcela de Melo Junqueira, Alzir Azevedo Batista, Monize Martins da Silva, Denise Crispim Tavares
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Effects of the tetravanadate [V4O12]4− anion on the structural, magnetic, and biological properties of copper/phenanthroline complexes J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2024-01-04 Eduardo Sánchez-Lara, Roberto Favela, Kitze Tzian, Brian Monroy-Torres, Adriana Romo-Pérez, María Teresa Ramírez-Apan, Marcos Flores-Alamo, Antonio Rodríguez-Diéguez, Javier Cepeda, Ivan Castillo
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Desulfurization of thiosemicarbazones: the role of metal ions and biological implications J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-12-26 Alondra Jiménez-Pérez, Sandra Fernández-Fariña, Rosa Pedrido, Javier García-Tojal
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The deposition of lanthanum carbonate may activate macrophages to induce gastrointestinal mucosal injury in patients with chronic kidney disease: an in vitro caco-2/THP-1 macrophage coculture model study J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-12-26 Ya-Ju Song, Hui-Xue Liu, Xiao-Gai Yang
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Synthesis, crystal structures, and biological activity of aroylhydrazone di-m-chlorobenzyltin complexes J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-12-23 Wujiu Jiang, Pengfei Zhou, Le Chen, Weiwei Fu, Yuxing Tan
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Bioactive apatite–wollastonite glass ceramics coating on metallic titanium for biomedical applications: effect of boron J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-12-20 Eren Yılmaz, Serbülent Türk, Alican Bahadır Semerci, Mine Kırkbınar, Erhan İbrahimoğlu, Fatih Çalışkan
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Characterization, modes of interactions with DNA/BSA biomolecules and anti-tumor activity of newly synthesized dinuclear platinum(II) complexes with pyridazine bridging ligand J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-12-15 Sanja Zornić, Bojana Simović Marković, Andjela A. Franich, Goran V. Janjić, Milka B. Jadranin, Jelena Avdalović, Snežana Rajković, Marija D. Živković, Nebojša N. Arsenijević, Gordana D. Radosavljević, Jelena Pantić
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Anti-toxoplasma activity and DNA-binding of copper(II) and zinc(II) coordination compounds with 5-nitroimidazole-based ligands J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-12-15 Rubí Navarro-Peñaloza, Jhony Anacleto-Santos, Norma Rivera-Fernández, Francisco Sánchez-Bartez, Isabel Gracia-Mora, Ana B. Caballero, Patrick Gamez, Norah Barba-Behrens
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6-Pyrazolylpurine and its deaza derivatives as nucleobases for silver(I)-mediated base pairing with pyrimidines J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-11-20 Daniela Escher, Tim Schäfer, Marian Hebenbrock, Jens Müller
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Gadolinium(III) complex formation with a β-cyclodextrin ligand: an XAS study of a potential MRI contrast agent J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-11-20 Farideh Jalilehvand, Saba Homayonia, Ping Zhang, Chang-Chun Ling
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Multistep synthesis of a novel copper complex with potential for Alzheimer’s disease diagnosis J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-11-17 Fatma Dellal, Diego Santo Domingo Porqueras, Stacy Narayanin-Richenapin, Marine Thimotee, Vanessa Delahaye, Yacine Diouf, Karolina Piasta, Elżbieta Gumienna-Kontecka, Henryk Kozlowski, Maryline Beyler, Raphael Tripier, Alban Moyeux, Olivier Gager, Valérie Besnard, Milena Salerno
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Circular permutation at azurin’s active site slows down its folding J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-11-13 Debanjana Das, Sri Rama Koti Ainavarapu
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In vitro and in vivo accumulation of the anticancer Ru complexes [RuII(cym)(HQ)Cl] and [RuII(cym)(PCA)Cl]Cl J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-11-14 Mie Riisom, Stuart J. Morrow, Caitlin D. Herbert, William D. J. Tremlett, Jonathan W. Astin, Stephen M. F. Jamieson, Christian G. Hartinger
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Dinuclear gold(I) complexes based on carbene and diphosphane ligands: bis[2-(dicyclohexylphosphano)ethyl]amine complex inhibits the proteasome activity, decreases stem cell markers and spheroid viability in lung cancer cells J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-11-13 Naike Casagrande, Cinzia Borghese, Giuseppe Corona, Donatella Aldinucci, Muhammad Altaf, Adam A. A. Sulaiman, Anvarhusein A. Isab, Saeed Ahmad, Abdul Malik P. Peedikakkal
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Synthesis, antimicrobial activity and molecular docking study of benzyl functionalized benzimidazole silver(I) complexes J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-11-07 Erkan Arı, Neslihan Şahin, Elvan Üstün, Muhammed Dündar, Hüseyin Karcı, İlknur Özdemir, Ahmet Koç, Nevin Gürbüz, İsmail Özdemir
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A novel palladium complex with a coumarin-thiosemicarbazone hybrid ligand inhibits Trypanosoma cruzi release from host cells and lowers the parasitemia in vivo J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-09-28 Santiago Rostán, Samuel Porto, Cesar L. N. Barbosa, Diego Assis, Natalia Alvarez, Fabiana Simão Machado, Graciela Mahler, Lucía Otero
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Assessment of 13 essential and toxic trace elements in tumor and peritumoral brain tissues from human glioblastoma J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-09-23 Hao-Long Zeng, Binmei Jia, Qing Yang, Fengbo Zeng, Huijun Li, Chao-Xi Li, Liming Cheng
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Initial characterization of an iron superoxide dismutase from Thermobifida fusca J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-09-19 Anne Grethe Hamre, Rim Al-Sadawi, Kirsti Merete Johannesen, Bastien Bisarro, Åsmund Røhr Kjendseth, Hanna-Kirsti S. Leiros, Morten Sørlie
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The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-09-01 Jelena Korać Jačić, Milena Dimitrijević, Danica Bajuk-Bogdanović, Dalibor Stanković, Slađana Savić, Ivan Spasojević, Milica R. Milenković
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Fractionation of selenium isotopes during biofortification of Saccharomyces cerevisiae and the influence of metabolic labeling with 15N J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-08-30 Luis Fernando Mejia Diaz, Jakub Karasinski, Kazimierz Wrobel, Alma Rosa Corrales Escobosa, Eunice Yanez Barrientos, Ludwik Halicz, Ewa Bulska, Katarzyna Wrobel
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The mechanism of antiproliferative activity of the oxaliplatin pyrophosphate derivative involves its binding to nuclear DNA in cancer cells J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-08-25 Jitka Prachařová, Hana Kostrhunová, Alessandra Barbanente, Nicola Margiotta, Viktor Brabec
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Sulfur-bridging the gap: investigating the electrochemistry of novel copper chelating agents for Alzheimer's disease applications J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-08-18 Emma Crnich, Erik Sanchez, Mallory A. Havens, Daniel S. Kissel
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Nickel chloride complexes with substituted 4′-phenyl-2′,2′:6′,2″-terpyridine ligands: synthesis, characterization, anti-proliferation activity and biomolecule interactions J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-31 Benwei Wang, Dameng Sun, Sihan Wang, Min Chen, Hongming Liu, Yanling Zhou, Hailan Chen, Zhen Ma
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Peroxidase activity of rice (Oryza sativa) hemoglobin: distinct role of tyrosines 112 and 151 J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-29 Valérie Derrien, Eric André, Sophie Bernad
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Ga(III) pyridinecarboxylate complexes: potential analogues of the second generation of therapeutic Ga(III) complexes? J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-27 Michaela Rendošová, Róbert Gyepes, Simona Sovová, Danica Sabolová, Mária Vilková, Petra Olejníková, Martin Kello, Boris Lakatoš, Zuzana Vargová
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The adducts of cyano- and aquacobalamin with hypochlorite J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-26 Maria Lehene, Adrian M. V. Brânzanic, Radu Silaghi-Dumitrescu
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meso-Bromination of cyano- and aquacobalamins facilitates their processing into Co(II)-species by glutathione J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-22 Ilia A. Dereven’kov, Vladimir S. Osokin, Ilya A. Khodov, Valentina V. Sobornova, Nikita A. Ershov, Sergei V. Makarov
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Interactions of arene ruthenium(II) complexes [η6-(C6H6)Ru(pprip)Cl]+ and [η6-(C6H6)Ru(H2iiP)Cl]+ with RNA triplex poly(U)•poly(A)*poly(U) J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-21 Feng Yuan, Xiaohua Liu, Juan Li, Lifeng Tan
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Control of nutrient metal availability during host-microbe interactions: beyond nutritional immunity J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-18 Karrera Y. Djoko
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Ferrocene-based nitroheterocyclic sulfonylhydrazones: design, synthesis, characterization and trypanocidal properties J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-18 Miguel Gallardo, Rodrigo Arancibia, Claudio Jiménez, Shane Wilkinson, Patricia M. Toro, Pascal Roussel, Natacha Henry
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Ferrozoles: Ferrocenyl derivatives of letrozole with dual effects as potent aromatase inhibitors and cytostatic agents J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-17 Borja Diaz de Greñu, Diego M. Fernández-Aroca, Juan A. Organero, Gema Durá, Felix Angel Jalón, Ricardo Sánchez-Prieto, M. José Ruiz-Hidalgo, Ana María Rodríguez, Lucia Santos, José L. Albasanz, Blanca R. Manzano
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Binding and stabilizating effect of RNA triplex poly(U)⋅poly(A)*poly(U) by enantiomers of ruthenium(II) polypyridyl complex [Ru(bpy)2(dppx)]2+ J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-15 Bingxin Wen, Xiaohua Liu, Lifeng Tan
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New platinum (II) complexes based on schiff bases: synthesis, specification, X-ray structure, ADMET, DFT, molecular docking, and anticancer activity against breast cancer J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-15 Mahboube Eslami Moghadam, Maryam Hasanzadeh Esfahani, Mahdi Behzad, Samaneh Zolghadri, Nadali Ramezani, Yasaman Azadi
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Development and application of metallo-phthalocyanines as potent G-quadruplex DNA binders and photosensitizers J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-07-14 Ariadna Gil-Martínez, Adrián Hernández, Cristina Galiana-Roselló, Sònia López-Molina, Javier Ortiz, Ángela Sastre-Santos, Enrique García-España, Jorge González-García
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Disruption of zinc (II) binding and dimeric protein structure of the XIAP-RING domain by copper (I) ions J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-06-02 Kathryn E. Splan, Sylvia R. Choi, Ruth E. Claycomb, Isaiah K. Eckart-Frank, Shreya Nagdev, Madeline E. Rodemeier
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Transesterification of RNA model induced by novel dinuclear copper (II) complexes with bis-tridentate imidazole derivatives J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-05-04 Xiuyang Wang, Jun Shu, Tong Ni, Chengxu Xu, Bin Xu, Xiaoqiang Liu, Kaiming Zhang, Weidong Jiang
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A novel water-soluble thiosemicarbazone Schiff base ligand and its complexes as potential anticancer agents and cellular fluorescence imaging J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-05-02 Sima Feizpour, Seyed Abolfazl Hosseini-Yazdi, Elham Safarzadeh, Behzad Baradaran, Michal Dusek, Morgane Poupon
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Synthesis, characterization, anticancer efficacy evaluation of ruthenium(II) and iridium(III) polypyridyl complexes toward A549 cells J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-04-25 Lijuan Liang, Yan Yang, Haimei Liu, Fang Yuan, Yuhan Yuan, Wenlong Li, Chunxia Huang, Jing Chen, Yunjun Liu
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Antimicrobial and anti-biofilm activity of silver nanoparticles biosynthesized with Cystoseira algae extracts J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-04-21 Mário Fernandes, Noelia González-Ballesteros, André da Costa, Raúl Machado, Andreia C. Gomes, Maria Carmen Rodríguez-Argüelles
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Steric hindrance, ligand ejection and associated photocytotoxic properties of ruthenium(II) polypyridyl complexes J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-04-15 Piedad Herrera-Ramírez, Sarah Alina Berger, Dana Josa, David Aguilà, Ana B. Caballero, Pere Fontova, Vanessa Soto-Cerrato, Manuel Martínez, Patrick Gamez
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High-efficiency oxygen evolution by photosystem II oxygen-evolving complex containing 3Mn per reaction center J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-04-12 Boris К. Semin, Lira N. Davletshina
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Biomimetic synthesis of hydroxytyrosol from conversion of tyrosol by mimicking tyrosine hydroxylase J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-04-05 Chan Chen, Weikang Tang, Qinfei Chen, Mengqi Han, Qi Shang, Wenbin Liu
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Targeting cancer lactate metabolism with synergistic combinations of synthetic catalysts and monocarboxylate transporter inhibitors J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-03-08 Hannah E. Bridgewater, Elizabeth M. Bolitho, Isolda Romero-Canelón, Peter J. Sadler, James P. C. Coverdale
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Research on synthesis and property of nano-textured Sc2O3-MgO efficient antibacterial agents J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-03-06 Ying Wang, Yanjing Liu, Xiyue Li, Yuezhou Liu, Fuming Wang, Yaping Huang, Bing Du, Yongfang Qian, Lihua Lv
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A personal account on 25 years of scientific literature on [FeFe]-hydrogenase J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-03-01 Jason W. Sidabras, Sven T. Stripp
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Histidine oxidation in lytic polysaccharide monooxygenase J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-02-25 Magne Torbjörnsson, Marlisa M. Hagemann, Ulf Ryde, Erik Donovan Hedegård
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Zinc binding of a Cys2His2-type zinc finger protein is enhanced by the interaction with DNA J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-02-23 Bálint Hajdu, Éva Hunyadi-Gulyás, Kohsuke Kato, Atsushi Kawaguchi, Kyosuke Nagata, Béla Gyurcsik
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Cyanide replaces substrate in obligate-ordered addition of nitric oxide to the non-heme mononuclear iron AvMDO active site J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-02-21 Nicholas J. York, Molly M. Lockart, Allison N. Schmittou, Brad S. Pierce
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Tumor selective Ru(III) Schiff bases complexes with strong in vitro activity toward cisplatin-resistant MDA-MB-231 breast cancer cells J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-02-13 Marijana Pavlović, Emira Kahrović, Sandra Aranđelović, Siniša Radulović, Predrag-Peter Ilich, Sanja Grgurić-Šipka, Nevzeta Ljubijankić, Dijana Žilić, Jurica Jurec
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The past, present, and future of artificial zinc finger proteins: design strategies and chemical and biological applications J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-02-07 Shigeru Negi, Miki Imanishi, Mami Hamori, Yuka Kawahara-Nakagawa, Wataru Nomura, Kanae Kishi, Nobuhito Shibata, Yukio Sugiura
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Synthesis, structural characterization and study of antioxidant and anti-PrPSc properties of flavonoids and their rhenium(I)–tricarbonyl complexes J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-01-25 Pigi Glykofridi, Vassiliki-Eleni Tziouri, Konstantinos Xanthopoulos, Maria-Eirini Vlachou, Susana Correia, Anna-Lisa Fischer, Katrin Thüne, Antonios Hatzidimitriou, Inga Zerr, Matthias Schmitz, Theodoros Sklaviadis, Dimitra Hadjipavlou-Litina, Dionysia Papagiannopoulou
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Quantum tunneling time delay investigation of $${{\varvec{K}}}^{+}$$ ion in human telomeric G-quadruplex systems J. Biol. Inorg. Chem. (IF 3.0) Pub Date : 2023-01-19 Gizem Celebi Torabfam, Güleser K. Demir, Durmuş Demir