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Constants and variations in 69 diverse genomes of Arabidopsis thaliana Nat. Genet. (IF 30.8) Pub Date : 2024-04-18
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Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder Nat. Genet. (IF 30.8) Pub Date : 2024-04-18 Caroline M. Nievergelt, Adam X. Maihofer, Elizabeth G. Atkinson, Chia-Yen Chen, Karmel W. Choi, Jonathan R. I. Coleman, Nikolaos P. Daskalakis, Laramie E. Duncan, Renato Polimanti, Cindy Aaronson, Ananda B. Amstadter, Soren B. Andersen, Ole A. Andreassen, Paul A. Arbisi, Allison E. Ashley-Koch, S. Bryn Austin, Esmina Avdibegoviç, Dragan Babić, Silviu-Alin Bacanu, Dewleen G. Baker, Anthony Batzler,
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Genetic modifiers of rare variants in monogenic developmental disorder loci Nat. Genet. (IF 30.8) Pub Date : 2024-04-18 Rebecca Kingdom, Robin N. Beaumont, Andrew R. Wood, Michael N. Weedon, Caroline F. Wright
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Londoners see what a scientist looks like up close in 50 photographs Nature (IF 64.8) Pub Date : 2024-04-18
Nature’s Where I Work images are being exhibited in the UK capital until June.
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Burnt remains of Maya royalty mark a dramatic power shift Nature (IF 64.8) Pub Date : 2024-04-18
Finds in pyramid at Guatemalan site suggest that remains were disinterred and desecrated in a public ritual.
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Violent volcanoes have wracked Jupiter’s moon Io for billions of years Nature (IF 64.8) Pub Date : 2024-04-18
Understanding the volcanic moon’s history could offer fresh insights into conditions on early Earth.
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Meet ‘goldene’: this gilded cousin of graphene is also one atom thick Nature (IF 64.8) Pub Date : 2024-04-18
Sheets of gold might find use as catalysts, or in light-sensing devices.
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AI’s keen diagnostic eye Nature (IF 64.8) Pub Date : 2024-04-18
Powered by deep-learning algorithms, artificial intelligence systems could replace agents such as chemicals currently used to augment medical scans.
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This water bottle purifies your drink with energy from your steps Nature (IF 64.8) Pub Date : 2024-04-17
Static electricity generated by the foot striking the ground can be captured to kill pathogens.
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Promiscuous G-protein activation by the calcium-sensing receptor Nature (IF 64.8) Pub Date : 2024-04-17 Hao Zuo, Jinseo Park, Aurel Frangaj, Jianxiang Ye, Guanqi Lu, Jamie J. Manning, Wesley B. Asher, Zhengyuan Lu, Guo-bin Hu, Liguo Wang, Joshua Mendez, Edward Eng, Zhening Zhang, Xin Lin, Robert Grassucci, Wayne A. Hendrickson, Oliver B. Clarke, Jonathan A. Javitch, Arthur D. Conigrave, Qing R. Fan
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Control of neuronal excitation–inhibition balance by BMP–SMAD1 signalling Nature (IF 64.8) Pub Date : 2024-04-17 Zeynep Okur, Nadia Schlauri, Vassilis Bitsikas, Myrto Panopoulou, Raul Ortiz, Michaela Schwaiger, Kajari Karmakar, Dietmar Schreiner, Peter Scheiffele
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Smoking bans are coming: what does the evidence say? Nature (IF 64.8) Pub Date : 2024-04-17
Countries are cracking down on tobacco use and vaping — the laws could save thousands of lives and billions of dollars, say scientists.
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Exploring the lung microbiome’s role in disease Nature (IF 64.8) Pub Date : 2024-04-17
Unusual microbial communities in a person’s lower airways could influence the onset and progression of lung cancer and other conditions, and might point the way to therapies.
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Dad always mows on summer Saturday mornings Nature (IF 64.8) Pub Date : 2024-04-17
A clear-cut success.
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Researchers want a ‘nutrition label’ for academic-paper facts Nature (IF 64.8) Pub Date : 2024-04-17
An ‘at a glance’ approach to publication details, such as journal acceptance rates and the number of peer reviewers, would promote transparency, scientists say.
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We must protect the global plastics treaty from corporate interference Nature (IF 64.8) Pub Date : 2024-04-17
A United Nations-backed agreement to end plastic pollution is within reach — but only if scientists, civil society and businesses unite against powerful vested interests.
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Deadly diseases and inflatable suits: how I found my niche in virology research Nature (IF 64.8) Pub Date : 2024-04-17
Virologist Hulda Jónsdóttir studies some of the world’s most pathogenic viruses at the Spiez Laboratory in Switzerland.
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Nanoparticle fix opens up tricky technique to forensic applications Nature (IF 64.8) Pub Date : 2024-04-17 Peter J. Vikesland
A technique for measuring trace quantities of molecules in water.
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How young people benefit from Swiss apprenticeships Nature (IF 64.8) Pub Date : 2024-04-17
Computational biologist Jitao David Zhang says that the country’s vocational training programme teaches key work and life skills.
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Coupled neural activity controls working memory in humans Nature (IF 64.8) Pub Date : 2024-04-17 Ziv Williams
Temporarily holding on to information depends on coordinated brain waves.
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CERN’s impact goes way beyond tiny particles Nature (IF 64.8) Pub Date : 2024-04-17
A global effort to uncover the nature of the Universe has had resounding effects on scientists and society.
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UN plastics treaty: don’t let lobbyists drown out researchers Nature (IF 64.8) Pub Date : 2024-04-17
Tackling plastic pollution needs scientists to be in the negotiating room at upcoming talks.
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Canadian science gets biggest boost to PhD and postdoc pay in 20 years Nature (IF 64.8) Pub Date : 2024-04-17
Government budget includes more money for basic research and notable increases to postgraduate stipends.
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Humans and their livestock have sheltered in this Saudi Arabian cave for 10,000 years Nature (IF 64.8) Pub Date : 2024-04-17
Saudi herders have travelled the same routes for millennia, cave discovery suggests.
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Keys, wallet, phone: the neuroscience behind working memory Nature (IF 64.8) Pub Date : 2024-04-17
Hear the biggest stories from the world of science | 17 April 2024
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I dive for fish in the longest freshwater lake in the world Nature (IF 64.8) Pub Date : 2024-04-17
Biologist Carolin Sommer-Trembo describes her fascination for fish and why she enjoys doing science in Switzerland.
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Bacteria deploy umbrella toxins against their competitors Nature (IF 64.8) Pub Date : 2024-04-17 Sarah J. Coulthurst
Streptomyces bacteria make a previously unknown antibacterial agent.
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Surprise hybrid origins of a butterfly species Nature (IF 64.8) Pub Date : 2024-04-17 Megan E. Frayer, Jenn M. Coughlan
Longwing butterfly species found to be a rare type of hybrid.
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An exploration of how the insect-wing hinge functions Nature (IF 64.8) Pub Date : 2024-04-17 Tanvi Deora
Insights into control of the joints that connect fly wings to their body.
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AI traces mysterious metastatic cancers to their source Nature (IF 64.8) Pub Date : 2024-04-17
Algorithm examines images of metastatic cells to identify the location of the primary tumour.
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What toilets can reveal about COVID, cancer and other health threats Nature (IF 64.8) Pub Date : 2024-04-17
Wastewater testing grew tremendously during the pandemic. But is it ready to tackle the opioid crisis, air pollution and antibiotic resistance?
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The sympathetic nervous system arose in the earliest vertebrates Nature (IF 64.8) Pub Date : 2024-04-17 Uwe Ernsberger, Hermann Rohrer
Jawless vertebrate has sympathetic neurons.
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How India can become a science powerhouse Nature (IF 64.8) Pub Date : 2024-04-16
As the world’s largest election kicks off this week, India has an opportunity to reimagine science funding.
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Large-scale photonic chiplet Taichi empowers 160-TOPS/W artificial general intelligence Science (IF 56.9) Pub Date : 2024-04-12 Zhihao Xu, Tiankuang Zhou, Muzhou Ma, ChenChen Deng, Qionghai Dai, Lu Fang
The pursuit of artificial general intelligence (AGI) continuously demands higher computing performance. Despite the superior processing speed and efficiency of integrated photonic circuits, their capacity and scalability are restricted by unavoidable errors, such that only simple tasks and shallow models are realized. To support modern AGIs, we designed Taichi—large-scale photonic chiplets based on
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Improved charge extraction in inverted perovskite solar cells with dual-site-binding ligands Science (IF 56.9) Pub Date : 2024-04-12 Hao Chen, Cheng Liu, Jian Xu, Aidan Maxwell, Wei Zhou, Yi Yang, Qilin Zhou, Abdulaziz S. R. Bati, Haoyue Wan, Zaiwei Wang, Lewei Zeng, Junke Wang, Peter Serles, Yuan Liu, Sam Teale, Yanjiang Liu, Makhsud I. Saidaminov, Muzhi Li, Nicholas Rolston, Sjoerd Hoogland, Tobin Filleter, Mercouri G. Kanatzidis, Bin Chen, Zhijun Ning, Edward H. Sargent
Inverted (pin) perovskite solar cells (PSCs) afford improved operating stability in comparison to their nip counterparts but have lagged in power conversion efficiency (PCE). The energetic losses responsible for this PCE deficit in pin PSCs occur primarily at the interfaces between the perovskite and the charge-transport layers. Additive and surface treatments that use passivating ligands usually bind
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Ultrahigh energy storage in high-entropy ceramic capacitors with polymorphic relaxor phase Science (IF 56.9) Pub Date : 2024-04-12 Min Zhang, Shun Lan, Bing B. Yang, Hao Pan, Yi Q. Liu, Qing H. Zhang, Jun L. Qi, Di Chen, Hang Su, Di Yi, Yue Y. Yang, Rui Wei, Hong D. Cai, Hao J. Han, Lin Gu, Ce-Wen Nan, Yuan-Hua Lin
Ultrahigh–power-density multilayer ceramic capacitors (MLCCs) are critical components in electrical and electronic systems. However, the realization of a high energy density combined with a high efficiency is a major challenge for practical applications. We propose a high-entropy design in barium titanate (BaTiO3)–based lead-free MLCCs with polymorphic relaxor phase. This strategy effectively minimizes
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Closed-loop recyclability of a biomass-derived epoxy-amine thermoset by methanolysis Science (IF 56.9) Pub Date : 2024-04-12 Xianyuan Wu, Peter Hartmann, Dimitri Berne, Mario De bruyn, Florian Cuminet, Zhiwen Wang, Johannes Matthias Zechner, Adrian Daniel Boese, Vincent Placet, Sylvain Caillol, Katalin Barta
Epoxy resin thermosets (ERTs) are an important class of polymeric materials. However, owing to their highly cross-linked nature, they suffer from poor recyclability, which contributes to an unacceptable level of environmental pollution. There is a clear need for the design of inherently recyclable ERTs that are based on renewable resources. We present the synthesis and closed-loop recycling of a fully
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Reinforcement learning informs optimal treatment strategies to limit antibiotic resistance Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-12 Davis T. WeaverEshan S. KingJeff MaltasJacob G. ScottaCase Western Reserve University School of Medicine, Cleveland, OH 44106bTranslational Hematology Oncology Research, Cleveland Clinic, Cleveland, OH 44106cDepartment of Physics, Case Western Reserve University, Cleveland, OH 44106
Proceedings of the National Academy of Sciences, Volume 121, Issue 16, April 2024.
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Extracellular vesicles released by keratinocytes regulate melanosome maturation, melanocyte dendricity, and pigment transfer Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-12 Marie-Thérèse ProspériCécile GiordanoMireia Gomez-DuroIlse HurbainAnne-Sophie MacéGraça RaposoGisela D’AngeloaInstitut Curie, Paris Sciences & Letters Research University, CNRS, UMR144, Structure and Membrane Compartments, Paris Cedex 05 75248, FrancebInstitut Curie, Paris Sciences & Letters Research University, CNRS, UMR144, Cell and Tissue Imaging Facility (The Cell and Tissue Imaging Platform (PICT-IBiSA))
Proceedings of the National Academy of Sciences, Volume 121, Issue 16, April 2024.
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Emerging roles for ABC transporters as virulence factors in uropathogenic Escherichia coli Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-12 Allyson E. SheaValerie S. ForsythJolie A. StockiTaylor J. MitchellArwen E. Frick-ChengSara N. SmithSicily L. HardyHarry L. T. MobleyaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109bDepartment of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL 36688
Proceedings of the National Academy of Sciences, Volume 121, Issue 16, April 2024.
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Posttranscriptional regulation of FAN1 by miR-124-3p at rs3512 underlies onset-delaying genetic modification in Huntington’s disease Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-12 Kyung-Hee KimEun Pyo HongYukyeong LeeZachariah L. McLeanEmanuela EleziRamee LeeSeung KwakBranduff McAllisterThomas H. MasseySergey LobanovPeter HolmansMichael OrthMarc CiosiDarren G. MoncktonJeffrey D. LongDiane LucenteVanessa C. WheelerMarcy E. MacDonaldJames F. GusellaJong-Min LeeaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114bDepartment of Neurology, Harvard Medical
Proceedings of the National Academy of Sciences, Volume 121, Issue 16, April 2024.
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Linking fine root lifespan to root chemical and morphological traits—A global analysis Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-12 Jiawen HouM. Luke McCormackPeter B. ReichTao SunRichard P. PhillipsHans LambersHan Y. H. ChenYiyang DingLouise H. ComasOscar J. Valverde-BarrantesEmily F. SollyGregoire T. FreschetaChinese Academy of Sciences Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, ChinabCollege of Resources and Environment, University of Chinese
Proceedings of the National Academy of Sciences, Volume 121, Issue 16, April 2024.
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Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis Nat. Genet. (IF 30.8) Pub Date : 2024-04-17 Jonas Ghouse, Gardar Sveinbjörnsson, Marijana Vujkovic, Anne-Sofie Seidelin, Helene Gellert-Kristensen, Gustav Ahlberg, Vinicius Tragante, Søren A. Rand, Joseph Brancale, Silvia Vilarinho, Pia Rengtved Lundegaard, Erik Sørensen, Christian Erikstrup, Mie Topholm Bruun, Bitten Aagaard Jensen, Søren Brunak, Karina Banasik, Henrik Ullum, Niek Verweij, Luca Lotta, Aris Baras, Tooraj Mirshahi, David J. Carey
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Customized molecular glue complexes with desired properties Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17 Iris Marchal
Degron tags can trigger rapid and temporally controlled degradation of proteins using small molecules known as molecular glues. These molecular glues induce or stabilize protein interactions between a target protein and a ubiquitin ligase. As research tools, molecular glue complexes are limited by the large size of degron tags, which prevents integration in endogenous protein-coding genes. In a study
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World’s priciest drug treats MLD Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
The US Food and Drug Administration has approved the first therapy for metachromatic leukodystrophy (MLD), a rare fatal genetic disorder. The lysosomal storage disease affects about 40 children each year in the USA. It is caused by a mutation in the gene encoding the arylsulfatase enzyme that leads to progressive demyelination and progressive loss of motor and cognitive functions. There were previously
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Saving Cavendish Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
Farmers have a green light to grow the first genetically modified banana. The wilt-proof strain of the Cavendish banana developed by researchers from the Queensland University of Technology is resistant to Panama disease (Fusarium wilt), a devastating fungus. The Office of the Gene Technology Regulator in Australia gave the go-ahead on 12 February to allow the genetically modified banana to be grown
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Prime editing Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
Recent patents relating to methods and compositions for prime editing.
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FDA approves first MASH drug Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
The first drug to treat fatty liver disease due to metabolic dysfunction-associated steatohepatitis (MASH) has been given a green light by the US Food and Drug Administration. Madrigal Pharmaceuticals’ Rezdiffra (resmetirom) received an accelerated approval to treat the disease, previously known as non-alcoholic steatohepatitis (NASH). In this progressive liver condition fat buildup triggers inflammation
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Biotech news from around the world Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
The Ministry of Health and Welfare selects Johnson & Johnson’s JLABS to operate the country’s global accelerator platform. JLABS will engage with various local incubators and collaborators in the startup ecosystem to offer venture development programs, stimulate employment and encourage commercialization to enhance the global competitiveness of Korea’s life sciences sector. Costa Rica revises its biotech
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First gene-edited pig kidney transplant Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
Surgeons at Massachusetts General Hospital have transplanted a pig kidney into a living person for the first time. On 16 March, a 62-year old man with end-stage kidney disease received a kidney from a genome-edited pig developed by eGenesis. The humanized pig organ was taken from a genetically engineered Yucatan miniature pig carrying a total of 69 gene edits designed to increase compatibility between
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RoseTTAFold expands to all-atom for biomolecular prediction and design Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17 Iris Marchal
Deep learning methods enable the structural prediction of proteins with high accuracy but are unable to model non-protein molecules that are essential for a protein’s biological function. Writing in Science, Krishna et al. introduce RoseTTAFold All-Atom (RFAA) to model the structure of full biological assemblies containing proteins, nucleic acids, small molecules, metals and covalent modifications
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Mapping the landscape of host–microbiome interactions Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17 Iris Marchal
The human body hosts countless microorganisms that play diverse roles in health and disease. However, the lack of tools capable of investigating these host–microbiota interactions at large scale has left many of them undiscovered. Writing in Nature, Sonnert et al. developed and validated a tool, named BASEHIT, to map the broad interplay between bacteria and human proteins. BASEHIT identified an extensive
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Prime editing deal flurry to nail down patent rights Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
The prime editing field is booming, with companies making strategic decisions to avoid an IP showdown.
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Startups probe hidden viruses in the ‘dark genome’ to treat disease Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
Drug hunters are finding that ancient virus-like artifacts in the human genome could offer new avenues to treat neurodegeneration, cancer, autoimmunity and even aging with antibodies, vaccines and antiretroviral agents.
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Video game unleashes millions of citizen scientists on microbiome research Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
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Five questions with César de la Fuente Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17 Michael Francisco
A pioneer in the emerging fields of AI for antibiotic discovery and molecular de-extinction describes his transdisciplinary background and lifelong passion to understand biology.
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People Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
Recent moves of note in and around the biotech and pharma industries.
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Mapping the global landscape for induced pluripotent stem cells from patents and clinical trials Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17 Liyang Lyu, Ye Feng, Borong Huang, Ren-He Xu, Yuanjia Hu
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Sharing best practices for educational programs on venture creation and commercialization Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17 Jordan Eidlisz, Zachary Hill-Whilton, Gabriel Vizgan, Daniel Cobos, Sadhana Chitale, Colleen Gillespie, Nabil Dib, Gabrielle Gold-von Simson
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AI and robotics demystify the workings of a fly's wing Nature (IF 64.8) Pub Date : 2024-04-17
New research unveils the workings of one of the most complex bio-mechanical structures in the natural world